CN103800686B - 一种治疗急性放射性皮炎的药物 - Google Patents
一种治疗急性放射性皮炎的药物 Download PDFInfo
- Publication number
- CN103800686B CN103800686B CN201410089022.XA CN201410089022A CN103800686B CN 103800686 B CN103800686 B CN 103800686B CN 201410089022 A CN201410089022 A CN 201410089022A CN 103800686 B CN103800686 B CN 103800686B
- Authority
- CN
- China
- Prior art keywords
- grams
- radix
- gram
- medicine
- blood
- Prior art date
Links
- 239000003814 drugs Substances 0.000 title claims abstract description 60
- 208000006934 Radiodermatitis Diseases 0.000 title claims abstract description 18
- 230000001154 acute Effects 0.000 title claims abstract description 16
- 238000005406 washing Methods 0.000 claims abstract description 16
- 241001057584 Myrrha Species 0.000 claims abstract description 10
- 241000628997 Flos Species 0.000 claims abstract description 9
- 235000003935 Hippophae Nutrition 0.000 claims abstract description 9
- 241000229143 Hippophae Species 0.000 claims abstract description 9
- 241001250596 Pleione Species 0.000 claims abstract description 9
- 229940079593 drugs Drugs 0.000 claims description 17
- 239000011901 water Substances 0.000 claims description 9
- 239000008280 blood Substances 0.000 abstract description 29
- 210000004369 Blood Anatomy 0.000 abstract description 27
- 230000001737 promoting Effects 0.000 abstract description 13
- 230000017531 blood circulation Effects 0.000 abstract description 12
- 231100000614 Poisons Toxicity 0.000 abstract description 9
- 239000003440 toxic substances Substances 0.000 abstract description 7
- 238000001816 cooling Methods 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 5
- 230000000414 obstructive Effects 0.000 abstract description 4
- 238000005469 granulation Methods 0.000 abstract description 3
- 230000003179 granulation Effects 0.000 abstract description 3
- 208000010201 Exanthema Diseases 0.000 abstract description 2
- 206010037844 Rash Diseases 0.000 abstract description 2
- 230000003115 biocidal Effects 0.000 abstract description 2
- 230000036772 blood pressure Effects 0.000 abstract description 2
- 230000004087 circulation Effects 0.000 abstract description 2
- 201000005884 exanthem Diseases 0.000 abstract description 2
- 239000002994 raw materials Substances 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 description 12
- 210000004185 Liver Anatomy 0.000 description 11
- 206010037660 Pyrexia Diseases 0.000 description 11
- 206010007247 Carbuncle Diseases 0.000 description 9
- 230000001717 pathogenic Effects 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 7
- 210000000952 Spleen Anatomy 0.000 description 7
- 206010068760 Ulcers Diseases 0.000 description 7
- 231100000397 ulcers Toxicity 0.000 description 7
- 208000003251 Pruritus Diseases 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 238000001959 radiotherapy Methods 0.000 description 6
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 208000001780 Epistaxis Diseases 0.000 description 5
- 210000003734 Kidney Anatomy 0.000 description 5
- 210000004072 Lung Anatomy 0.000 description 5
- 210000003491 Skin Anatomy 0.000 description 5
- 201000000736 amenorrhea Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000002522 swelling Effects 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 208000005679 Eczema Diseases 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 206010022114 Injuries Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 206010062080 Pigmentation diseases Diseases 0.000 description 4
- 201000004624 dermatitis Diseases 0.000 description 4
- 231100001003 eczema Toxicity 0.000 description 4
- 201000007227 lymph node tuberculosis Diseases 0.000 description 4
- 244000052769 pathogens Species 0.000 description 4
- 230000019612 pigmentation Effects 0.000 description 4
- 238000002360 preparation methods Methods 0.000 description 4
- 206010016286 Febrile diseases Diseases 0.000 description 3
- 206010018836 Haematochezia Diseases 0.000 description 3
- 206010018987 Haemorrhages Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010027327 Menstrual diseases Diseases 0.000 description 3
- 206010029410 Night sweats Diseases 0.000 description 3
- 208000008425 Protein Deficiency Diseases 0.000 description 3
- 206010072736 Rheumatic diseases Diseases 0.000 description 3
- 206010040943 Skin ulcer Diseases 0.000 description 3
- 210000002784 Stomach Anatomy 0.000 description 3
- 206010043458 Thirst Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000035614 depigmentation Effects 0.000 description 3
- 201000010099 diseases Diseases 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 230000036565 night sweats Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000000552 rheumatic Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 210000001015 Abdomen Anatomy 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 280000867709 Crimson companies 0.000 description 2
- 241001081830 Degeneriaceae Species 0.000 description 2
- 208000002173 Dizziness Diseases 0.000 description 2
- 208000001848 Dysentery Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010018830 Haematemesis Diseases 0.000 description 2
- 206010024229 Leprosy Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000005687 Scabies Diseases 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 206010040872 Skin infection Diseases 0.000 description 2
- 206010043189 Telangiectasia Diseases 0.000 description 2
- 208000009056 Telangiectasis Diseases 0.000 description 2
- 210000003932 Urinary Bladder Anatomy 0.000 description 2
- 210000002700 Urine Anatomy 0.000 description 2
- 231100000319 bleeding Toxicity 0.000 description 2
- 230000000740 bleeding Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 231100000915 pathological changes Toxicity 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000025627 positive regulation of urine volume Effects 0.000 description 2
- 230000001047 pyretic Effects 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010001093 Acute tonsillitis Diseases 0.000 description 1
- 206010002383 Angina pectoris Diseases 0.000 description 1
- 208000002399 Aphthous Stomatitis Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 235000010894 Artemisia argyi Nutrition 0.000 description 1
- 241001249158 Artemisia verlotiorum Species 0.000 description 1
- 206010003549 Asthenia Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 208000002894 Beriberi Diseases 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 240000007311 Commiphora myrrha Species 0.000 description 1
- 235000006965 Commiphora myrrha Nutrition 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 208000006111 Contracture Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010013023 Diphtheria Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229940012952 Fibrinogen Drugs 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 101710002935 Fibrinogen Proteins 0.000 description 1
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 description 1
- 210000000232 Gallbladder Anatomy 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 210000001624 Hip Anatomy 0.000 description 1
- 210000003026 Hypopharynx Anatomy 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010022437 Insomnia Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 210000003127 Knee Anatomy 0.000 description 1
- 241000321541 Leptolegnia sp. Species 0.000 description 1
- 208000007106 Menorrhagia Diseases 0.000 description 1
- 210000000214 Mouth Anatomy 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 210000002381 Plasma Anatomy 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 240000001816 Prunella vulgaris Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 210000000582 Semen Anatomy 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 210000004304 Subcutaneous Tissue Anatomy 0.000 description 1
- 210000000106 Sweat Glands Anatomy 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 231100000765 Toxins Toxicity 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000003905 Vulva Anatomy 0.000 description 1
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 1
- 230000002159 abnormal effects Effects 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 201000004384 alopecia Diseases 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000008338 calamine lotion Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 201000009541 complex regional pain syndrome Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000003628 erosive Effects 0.000 description 1
- 201000005619 esophageal carcinoma Diseases 0.000 description 1
- 239000000686 essences Substances 0.000 description 1
- 230000001815 facial Effects 0.000 description 1
- 230000001605 fetal Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019525 fullness Nutrition 0.000 description 1
- 239000007789 gases Substances 0.000 description 1
- 230000002496 gastric Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002607 hemopoietic Effects 0.000 description 1
- 230000002440 hepatic Effects 0.000 description 1
- 230000001939 inductive effects Effects 0.000 description 1
- 230000002757 inflammatory Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000003902 lesions Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000003211 malignant Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000002175 menstrual Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000000034 methods Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000002674 ointments Substances 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 239000002574 poisons Substances 0.000 description 1
- 239000000843 powders Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 230000000268 renotropic Effects 0.000 description 1
- 239000011347 resins Substances 0.000 description 1
- 229920005989 resins Polymers 0.000 description 1
- 239000012266 salt solutions Substances 0.000 description 1
- 231100000241 scars Toxicity 0.000 description 1
- 235000008113 selfheal Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000000243 solutions Substances 0.000 description 1
- 239000000758 substrates Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 239000003053 toxins Substances 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 230000002087 whitening Effects 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300' height='300' x='0' y='0'> </rect>
<text dominant-baseline="central" text-anchor="end" x='59.2419' y='256.322' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='126.428' y='256.322' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='59.2419' y='189.136' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='193.614' y='256.322' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='18.4507' y='121.95' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Fe</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>+3</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='220.009' y='256.322' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Fe</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>+3</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='18.4507' y='54.7635' style='font-size:33px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Zn</tspan><tspan style='baseline-shift:super;font-size:24.75px;'>+2</tspan><tspan></tspan></text>
<path d='M 27.369,93.8995 L 27.3615,93.7262 L 27.3392,93.5542 L 27.3022,93.3848 L 27.2507,93.2192 L 27.1852,93.0586 L 27.1062,92.9043 L 27.0141,92.7573 L 26.9098,92.6187 L 26.7939,92.4897 L 26.6674,92.3711 L 26.5311,92.2638 L 26.3862,92.1686 L 26.2335,92.0862 L 26.0744,92.0173 L 25.9099,91.9623 L 25.7413,91.9216 L 25.5699,91.8956 L 25.3968,91.8844 L 25.2234,91.8881 L 25.051,91.9067 L 24.8808,91.9401 L 24.7141,91.988 L 24.5521,92.05 L 24.3961,92.1258 L 24.2472,92.2146 L 24.1064,92.316 L 23.9749,92.429 L 23.8536,92.553 L 23.7434,92.6869 L 23.6451,92.8298 L 23.5595,92.9806 L 23.4871,93.1382 L 23.4286,93.3015 L 23.3843,93.4691 L 23.3546,93.64 L 23.3397,93.8128 L 23.3397,93.9862 L 23.3546,94.159 L 23.3843,94.3299 L 23.4286,94.4976 L 23.4871,94.6608 L 23.5595,94.8184 L 23.6451,94.9692 L 23.7434,95.1121 L 23.8536,95.246 L 23.9749,95.37 L 24.1064,95.483 L 24.2472,95.5844 L 24.3961,95.6732 L 24.5521,95.749 L 24.7141,95.811 L 24.8808,95.8589 L 25.051,95.8923 L 25.2234,95.9109 L 25.3968,95.9146 L 25.5699,95.9034 L 25.7413,95.8774 L 25.9099,95.8367 L 26.0744,95.7817 L 26.2335,95.7128 L 26.3862,95.6304 L 26.5311,95.5352 L 26.6674,95.4279 L 26.7939,95.3093 L 26.9098,95.1803 L 27.0141,95.0417 L 27.1062,94.8948 L 27.1852,94.7404 L 27.2507,94.5798 L 27.3022,94.4142 L 27.3392,94.2448 L 27.3615,94.0728 L 27.369,93.8995 L 25.3534,93.8995 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 53.2357,93.8995 L 53.2282,93.7262 L 53.2059,93.5542 L 53.1689,93.3848 L 53.1174,93.2192 L 53.0519,93.0586 L 52.9729,92.9043 L 52.8808,92.7573 L 52.7765,92.6187 L 52.6606,92.4897 L 52.5341,92.3711 L 52.3978,92.2638 L 52.2528,92.1686 L 52.1002,92.0862 L 51.9411,92.0173 L 51.7766,91.9623 L 51.608,91.9216 L 51.4366,91.8956 L 51.2635,91.8844 L 51.0901,91.8881 L 50.9177,91.9067 L 50.7475,91.9401 L 50.5808,91.988 L 50.4188,92.05 L 50.2628,92.1258 L 50.1139,92.2146 L 49.9731,92.316 L 49.8416,92.429 L 49.7203,92.553 L 49.6101,92.6869 L 49.5118,92.8298 L 49.4262,92.9806 L 49.3538,93.1382 L 49.2953,93.3015 L 49.251,93.4691 L 49.2213,93.64 L 49.2064,93.8128 L 49.2064,93.9862 L 49.2213,94.159 L 49.251,94.3299 L 49.2953,94.4976 L 49.3538,94.6608 L 49.4262,94.8184 L 49.5118,94.9692 L 49.6101,95.1121 L 49.7203,95.246 L 49.8416,95.37 L 49.9731,95.483 L 50.1139,95.5844 L 50.2628,95.6732 L 50.4188,95.749 L 50.5808,95.811 L 50.7475,95.8589 L 50.9177,95.8923 L 51.0901,95.9109 L 51.2635,95.9146 L 51.4366,95.9034 L 51.608,95.8774 L 51.7766,95.8367 L 51.9411,95.7817 L 52.1002,95.7128 L 52.2528,95.6304 L 52.3978,95.5352 L 52.5341,95.4279 L 52.6606,95.3093 L 52.7765,95.1803 L 52.8808,95.0417 L 52.9729,94.8948 L 53.0519,94.7404 L 53.1174,94.5798 L 53.1689,94.4142 L 53.2059,94.2448 L 53.2282,94.0728 L 53.2357,93.8995 L 51.2201,93.8995 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 40.3024,93.8995 L 40.2949,93.7262 L 40.2726,93.5542 L 40.2355,93.3848 L 40.1841,93.2192 L 40.1186,93.0586 L 40.0395,92.9043 L 39.9475,92.7573 L 39.8431,92.6187 L 39.7273,92.4897 L 39.6007,92.3711 L 39.4645,92.2638 L 39.3195,92.1686 L 39.1669,92.0862 L 39.0077,92.0173 L 38.8433,91.9623 L 38.6747,91.9216 L 38.5032,91.8956 L 38.3301,91.8844 L 38.1567,91.8881 L 37.9843,91.9067 L 37.8141,91.9401 L 37.6474,91.988 L 37.4855,92.05 L 37.3295,92.1258 L 37.1805,92.2146 L 37.0398,92.316 L 36.9083,92.429 L 36.787,92.553 L 36.6768,92.6869 L 36.5785,92.8298 L 36.4928,92.9806 L 36.4205,93.1382 L 36.362,93.3015 L 36.3177,93.4691 L 36.288,93.64 L 36.2731,93.8128 L 36.2731,93.9862 L 36.288,94.159 L 36.3177,94.3299 L 36.362,94.4976 L 36.4205,94.6608 L 36.4928,94.8184 L 36.5785,94.9692 L 36.6768,95.1121 L 36.787,95.246 L 36.9083,95.37 L 37.0398,95.483 L 37.1805,95.5844 L 37.3295,95.6732 L 37.4855,95.749 L 37.6474,95.811 L 37.8141,95.8589 L 37.9843,95.8923 L 38.1567,95.9109 L 38.3301,95.9146 L 38.5032,95.9034 L 38.6747,95.8774 L 38.8433,95.8367 L 39.0077,95.7817 L 39.1669,95.7128 L 39.3195,95.6304 L 39.4645,95.5352 L 39.6007,95.4279 L 39.7273,95.3093 L 39.8431,95.1803 L 39.9475,95.0417 L 40.0395,94.8948 L 40.1186,94.7404 L 40.1841,94.5798 L 40.2355,94.4142 L 40.2726,94.2448 L 40.2949,94.0728 L 40.3024,93.8995 L 38.2868,93.8995 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 228.928,228.272 L 228.92,228.099 L 228.898,227.927 L 228.861,227.757 L 228.809,227.592 L 228.744,227.431 L 228.665,227.277 L 228.573,227.13 L 228.468,226.991 L 228.353,226.862 L 228.226,226.744 L 228.09,226.636 L 227.945,226.541 L 227.792,226.459 L 227.633,226.39 L 227.469,226.335 L 227.3,226.294 L 227.129,226.268 L 226.955,226.257 L 226.782,226.261 L 226.61,226.279 L 226.439,226.313 L 226.273,226.36 L 226.111,226.422 L 225.955,226.498 L 225.806,226.587 L 225.665,226.688 L 225.534,226.801 L 225.412,226.925 L 225.302,227.059 L 225.204,227.202 L 225.118,227.353 L 225.046,227.511 L 224.987,227.674 L 224.943,227.842 L 224.913,228.012 L 224.898,228.185 L 224.898,228.359 L 224.913,228.531 L 224.943,228.702 L 224.987,228.87 L 225.046,229.033 L 225.118,229.191 L 225.204,229.342 L 225.302,229.485 L 225.412,229.618 L 225.534,229.742 L 225.665,229.855 L 225.806,229.957 L 225.955,230.046 L 226.111,230.121 L 226.273,230.183 L 226.439,230.231 L 226.61,230.265 L 226.782,230.283 L 226.955,230.287 L 227.129,230.276 L 227.3,230.25 L 227.469,230.209 L 227.633,230.154 L 227.792,230.085 L 227.945,230.003 L 228.09,229.908 L 228.226,229.8 L 228.353,229.682 L 228.468,229.553 L 228.573,229.414 L 228.665,229.267 L 228.744,229.113 L 228.809,228.952 L 228.861,228.787 L 228.898,228.617 L 228.92,228.445 L 228.928,228.272 L 226.912,228.272 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 254.794,228.272 L 254.787,228.099 L 254.765,227.927 L 254.728,227.757 L 254.676,227.592 L 254.611,227.431 L 254.532,227.277 L 254.439,227.13 L 254.335,226.991 L 254.219,226.862 L 254.093,226.744 L 253.956,226.636 L 253.812,226.541 L 253.659,226.459 L 253.5,226.39 L 253.335,226.335 L 253.167,226.294 L 252.995,226.268 L 252.822,226.257 L 252.649,226.261 L 252.476,226.279 L 252.306,226.313 L 252.139,226.36 L 251.978,226.422 L 251.821,226.498 L 251.673,226.587 L 251.532,226.688 L 251.4,226.801 L 251.279,226.925 L 251.169,227.059 L 251.07,227.202 L 250.985,227.353 L 250.913,227.511 L 250.854,227.674 L 250.81,227.842 L 250.78,228.012 L 250.765,228.185 L 250.765,228.359 L 250.78,228.531 L 250.81,228.702 L 250.854,228.87 L 250.913,229.033 L 250.985,229.191 L 251.07,229.342 L 251.169,229.485 L 251.279,229.618 L 251.4,229.742 L 251.532,229.855 L 251.673,229.957 L 251.821,230.046 L 251.978,230.121 L 252.139,230.183 L 252.306,230.231 L 252.476,230.265 L 252.649,230.283 L 252.822,230.287 L 252.995,230.276 L 253.167,230.25 L 253.335,230.209 L 253.5,230.154 L 253.659,230.085 L 253.812,230.003 L 253.956,229.908 L 254.093,229.8 L 254.219,229.682 L 254.335,229.553 L 254.439,229.414 L 254.532,229.267 L 254.611,229.113 L 254.676,228.952 L 254.728,228.787 L 254.765,228.617 L 254.787,228.445 L 254.794,228.272 L 252.779,228.272 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 241.861,228.272 L 241.854,228.099 L 241.831,227.927 L 241.794,227.757 L 241.743,227.592 L 241.677,227.431 L 241.598,227.277 L 241.506,227.13 L 241.402,226.991 L 241.286,226.862 L 241.159,226.744 L 241.023,226.636 L 240.878,226.541 L 240.726,226.459 L 240.566,226.39 L 240.402,226.335 L 240.233,226.294 L 240.062,226.268 L 239.889,226.257 L 239.715,226.261 L 239.543,226.279 L 239.373,226.313 L 239.206,226.36 L 239.044,226.422 L 238.888,226.498 L 238.739,226.587 L 238.598,226.688 L 238.467,226.801 L 238.346,226.925 L 238.235,227.059 L 238.137,227.202 L 238.052,227.353 L 237.979,227.511 L 237.921,227.674 L 237.876,227.842 L 237.847,228.012 L 237.832,228.185 L 237.832,228.359 L 237.847,228.531 L 237.876,228.702 L 237.921,228.87 L 237.979,229.033 L 238.052,229.191 L 238.137,229.342 L 238.235,229.485 L 238.346,229.618 L 238.467,229.742 L 238.598,229.855 L 238.739,229.957 L 238.888,230.046 L 239.044,230.121 L 239.206,230.183 L 239.373,230.231 L 239.543,230.265 L 239.715,230.283 L 239.889,230.287 L 240.062,230.276 L 240.233,230.25 L 240.402,230.209 L 240.566,230.154 L 240.726,230.085 L 240.878,230.003 L 241.023,229.908 L 241.159,229.8 L 241.286,229.682 L 241.402,229.553 L 241.506,229.414 L 241.598,229.267 L 241.677,229.113 L 241.743,228.952 L 241.794,228.787 L 241.831,228.617 L 241.854,228.445 L 241.861,228.272 L 239.845,228.272 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85' height='85' x='0' y='0'> </rect>
<text dominant-baseline="central" text-anchor="end" x='16.2852' y='72.1246' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='35.3213' y='72.1246' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='16.2852' y='53.0885' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="end" x='54.3574' y='72.1246' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#E84235' ><tspan>O</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>-2</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='4.7277' y='34.0524' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Fe</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>+3</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='61.836' y='72.1246' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Fe</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>+3</tspan><tspan></tspan></text>
<text dominant-baseline="central" text-anchor="start" x='4.7277' y='15.0163' style='font-size:9px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;fill:#3B4143' ><tspan>Zn</tspan><tspan style='baseline-shift:super;font-size:6.75px;'>+2</tspan><tspan></tspan></text>
<path d='M 7.25455,26.1049 L 7.25244,26.0558 L 7.24611,26.007 L 7.23562,25.959 L 7.22104,25.9121 L 7.20248,25.8666 L 7.18008,25.8229 L 7.154,25.7812 L 7.12444,25.742 L 7.09161,25.7054 L 7.05576,25.6718 L 7.01715,25.6414 L 6.97608,25.6144 L 6.93283,25.5911 L 6.88775,25.5716 L 6.84114,25.556 L 6.79338,25.5445 L 6.74479,25.5371 L 6.69576,25.5339 L 6.64663,25.535 L 6.59778,25.5402 L 6.54956,25.5497 L 6.50233,25.5633 L 6.45644,25.5808 L 6.41223,25.6023 L 6.37004,25.6275 L 6.33016,25.6562 L 6.2929,25.6882 L 6.25852,25.7233 L 6.2273,25.7613 L 6.19945,25.8018 L 6.17519,25.8445 L 6.15469,25.8892 L 6.1381,25.9354 L 6.12556,25.9829 L 6.11714,26.0313 L 6.11292,26.0803 L 6.11292,26.1294 L 6.11714,26.1784 L 6.12556,26.2268 L 6.1381,26.2743 L 6.15469,26.3206 L 6.17519,26.3652 L 6.19945,26.408 L 6.2273,26.4484 L 6.25852,26.4864 L 6.2929,26.5215 L 6.33016,26.5535 L 6.37004,26.5822 L 6.41223,26.6074 L 6.45644,26.6289 L 6.50233,26.6465 L 6.54956,26.66 L 6.59778,26.6695 L 6.64663,26.6748 L 6.69576,26.6758 L 6.74479,26.6726 L 6.79338,26.6653 L 6.84114,26.6537 L 6.88775,26.6382 L 6.93283,26.6186 L 6.97608,26.5953 L 7.01715,26.5683 L 7.05576,26.5379 L 7.09161,26.5043 L 7.12444,26.4677 L 7.154,26.4285 L 7.18008,26.3868 L 7.20248,26.3431 L 7.22104,26.2976 L 7.23562,26.2507 L 7.24611,26.2027 L 7.25244,26.154 L 7.25455,26.1049 L 6.68347,26.1049 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 14.5835,26.1049 L 14.5813,26.0558 L 14.575,26.007 L 14.5645,25.959 L 14.5499,25.9121 L 14.5314,25.8666 L 14.509,25.8229 L 14.4829,25.7812 L 14.4533,25.742 L 14.4205,25.7054 L 14.3847,25.6718 L 14.346,25.6414 L 14.305,25.6144 L 14.2617,25.5911 L 14.2166,25.5716 L 14.17,25.556 L 14.1223,25.5445 L 14.0737,25.5371 L 14.0247,25.5339 L 13.9755,25.535 L 13.9267,25.5402 L 13.8785,25.5497 L 13.8312,25.5633 L 13.7853,25.5808 L 13.7411,25.6023 L 13.6989,25.6275 L 13.6591,25.6562 L 13.6218,25.6882 L 13.5874,25.7233 L 13.5562,25.7613 L 13.5284,25.8018 L 13.5041,25.8445 L 13.4836,25.8892 L 13.467,25.9354 L 13.4545,25.9829 L 13.446,26.0313 L 13.4418,26.0803 L 13.4418,26.1294 L 13.446,26.1784 L 13.4545,26.2268 L 13.467,26.2743 L 13.4836,26.3206 L 13.5041,26.3652 L 13.5284,26.408 L 13.5562,26.4484 L 13.5874,26.4864 L 13.6218,26.5215 L 13.6591,26.5535 L 13.6989,26.5822 L 13.7411,26.6074 L 13.7853,26.6289 L 13.8312,26.6465 L 13.8785,26.66 L 13.9267,26.6695 L 13.9755,26.6748 L 14.0247,26.6758 L 14.0737,26.6726 L 14.1223,26.6653 L 14.17,26.6537 L 14.2166,26.6382 L 14.2617,26.6186 L 14.305,26.5953 L 14.346,26.5683 L 14.3847,26.5379 L 14.4205,26.5043 L 14.4533,26.4677 L 14.4829,26.4285 L 14.509,26.3868 L 14.5314,26.3431 L 14.5499,26.2976 L 14.5645,26.2507 L 14.575,26.2027 L 14.5813,26.154 L 14.5835,26.1049 L 14.0124,26.1049 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 10.919,26.1049 L 10.9169,26.0558 L 10.9106,26.007 L 10.9001,25.959 L 10.8855,25.9121 L 10.8669,25.8666 L 10.8445,25.8229 L 10.8184,25.7812 L 10.7889,25.742 L 10.7561,25.7054 L 10.7202,25.6718 L 10.6816,25.6414 L 10.6405,25.6144 L 10.5973,25.5911 L 10.5522,25.5716 L 10.5056,25.556 L 10.4578,25.5445 L 10.4092,25.5371 L 10.3602,25.5339 L 10.3111,25.535 L 10.2622,25.5402 L 10.214,25.5497 L 10.1668,25.5633 L 10.1209,25.5808 L 10.0767,25.6023 L 10.0345,25.6275 L 9.99461,25.6562 L 9.95734,25.6882 L 9.92297,25.7233 L 9.89175,25.7613 L 9.8639,25.8018 L 9.83964,25.8445 L 9.81914,25.8892 L 9.80255,25.9354 L 9.79001,25.9829 L 9.78159,26.0313 L 9.77736,26.0803 L 9.77736,26.1294 L 9.78159,26.1784 L 9.79001,26.2268 L 9.80255,26.2743 L 9.81914,26.3206 L 9.83964,26.3652 L 9.8639,26.408 L 9.89175,26.4484 L 9.92297,26.4864 L 9.95734,26.5215 L 9.99461,26.5535 L 10.0345,26.5822 L 10.0767,26.6074 L 10.1209,26.6289 L 10.1668,26.6465 L 10.214,26.66 L 10.2622,26.6695 L 10.3111,26.6748 L 10.3602,26.6758 L 10.4092,26.6726 L 10.4578,26.6653 L 10.5056,26.6537 L 10.5522,26.6382 L 10.5973,26.6186 L 10.6405,26.5953 L 10.6816,26.5683 L 10.7202,26.5379 L 10.7561,26.5043 L 10.7889,26.4677 L 10.8184,26.4285 L 10.8445,26.3868 L 10.8669,26.3431 L 10.8855,26.2976 L 10.9001,26.2507 L 10.9106,26.2027 L 10.9169,26.154 L 10.919,26.1049 L 10.3479,26.1049 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 64.3628,64.1771 L 64.3607,64.128 L 64.3544,64.0792 L 64.3439,64.0312 L 64.3293,63.9843 L 64.3108,63.9388 L 64.2884,63.8951 L 64.2623,63.8534 L 64.2327,63.8142 L 64.1999,63.7776 L 64.164,63.744 L 64.1254,63.7136 L 64.0844,63.6866 L 64.0411,63.6633 L 63.996,63.6438 L 63.9494,63.6282 L 63.9017,63.6166 L 63.8531,63.6093 L 63.804,63.6061 L 63.7549,63.6072 L 63.7061,63.6124 L 63.6578,63.6219 L 63.6106,63.6355 L 63.5647,63.653 L 63.5205,63.6745 L 63.4783,63.6997 L 63.4384,63.7284 L 63.4012,63.7604 L 63.3668,63.7955 L 63.3356,63.8335 L 63.3077,63.874 L 63.2835,63.9167 L 63.263,63.9614 L 63.2464,64.0076 L 63.2338,64.0551 L 63.2254,64.1035 L 63.2212,64.1525 L 63.2212,64.2016 L 63.2254,64.2506 L 63.2338,64.299 L 63.2464,64.3465 L 63.263,64.3928 L 63.2835,64.4374 L 63.3077,64.4801 L 63.3356,64.5206 L 63.3668,64.5586 L 63.4012,64.5937 L 63.4384,64.6257 L 63.4783,64.6544 L 63.5205,64.6796 L 63.5647,64.7011 L 63.6106,64.7186 L 63.6578,64.7322 L 63.7061,64.7417 L 63.7549,64.7469 L 63.804,64.748 L 63.8531,64.7448 L 63.9017,64.7375 L 63.9494,64.7259 L 63.996,64.7104 L 64.0411,64.6908 L 64.0844,64.6675 L 64.1254,64.6405 L 64.164,64.6101 L 64.1999,64.5765 L 64.2327,64.5399 L 64.2623,64.5007 L 64.2884,64.459 L 64.3108,64.4153 L 64.3293,64.3698 L 64.3439,64.3229 L 64.3544,64.2749 L 64.3607,64.2261 L 64.3628,64.1771 L 63.7918,64.1771 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 71.6917,64.1771 L 71.6896,64.128 L 71.6833,64.0792 L 71.6728,64.0312 L 71.6582,63.9843 L 71.6397,63.9388 L 71.6173,63.8951 L 71.5912,63.8534 L 71.5616,63.8142 L 71.5288,63.7776 L 71.4929,63.744 L 71.4543,63.7136 L 71.4133,63.6866 L 71.37,63.6633 L 71.3249,63.6438 L 71.2783,63.6282 L 71.2306,63.6166 L 71.182,63.6093 L 71.1329,63.6061 L 71.0838,63.6072 L 71.035,63.6124 L 70.9867,63.6219 L 70.9395,63.6355 L 70.8936,63.653 L 70.8494,63.6745 L 70.8072,63.6997 L 70.7673,63.7284 L 70.7301,63.7604 L 70.6957,63.7955 L 70.6645,63.8335 L 70.6366,63.874 L 70.6124,63.9167 L 70.5919,63.9614 L 70.5753,64.0076 L 70.5627,64.0551 L 70.5543,64.1035 L 70.5501,64.1525 L 70.5501,64.2016 L 70.5543,64.2506 L 70.5627,64.299 L 70.5753,64.3465 L 70.5919,64.3928 L 70.6124,64.4374 L 70.6366,64.4801 L 70.6645,64.5206 L 70.6957,64.5586 L 70.7301,64.5937 L 70.7673,64.6257 L 70.8072,64.6544 L 70.8494,64.6796 L 70.8936,64.7011 L 70.9395,64.7186 L 70.9867,64.7322 L 71.035,64.7417 L 71.0838,64.7469 L 71.1329,64.748 L 71.182,64.7448 L 71.2306,64.7375 L 71.2783,64.7259 L 71.3249,64.7104 L 71.37,64.6908 L 71.4133,64.6675 L 71.4543,64.6405 L 71.4929,64.6101 L 71.5288,64.5765 L 71.5616,64.5399 L 71.5912,64.5007 L 71.6173,64.459 L 71.6397,64.4153 L 71.6582,64.3698 L 71.6728,64.3229 L 71.6833,64.2749 L 71.6896,64.2261 L 71.6917,64.1771 L 71.1207,64.1771 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 68.0273,64.1771 L 68.0252,64.128 L 68.0189,64.0792 L 68.0084,64.0312 L 67.9938,63.9843 L 67.9752,63.9388 L 67.9528,63.8951 L 67.9267,63.8534 L 67.8972,63.8142 L 67.8643,63.7776 L 67.8285,63.744 L 67.7899,63.7136 L 67.7488,63.6866 L 67.7056,63.6633 L 67.6605,63.6438 L 67.6139,63.6282 L 67.5661,63.6166 L 67.5175,63.6093 L 67.4685,63.6061 L 67.4194,63.6072 L 67.3705,63.6124 L 67.3223,63.6219 L 67.2751,63.6355 L 67.2292,63.653 L 67.185,63.6745 L 67.1428,63.6997 L 67.1029,63.7284 L 67.0656,63.7604 L 67.0313,63.7955 L 67,63.8335 L 66.9722,63.874 L 66.9479,63.9167 L 66.9274,63.9614 L 66.9108,64.0076 L 66.8983,64.0551 L 66.8899,64.1035 L 66.8857,64.1525 L 66.8857,64.2016 L 66.8899,64.2506 L 66.8983,64.299 L 66.9108,64.3465 L 66.9274,64.3928 L 66.9479,64.4374 L 66.9722,64.4801 L 67,64.5206 L 67.0313,64.5586 L 67.0656,64.5937 L 67.1029,64.6257 L 67.1428,64.6544 L 67.185,64.6796 L 67.2292,64.7011 L 67.2751,64.7186 L 67.3223,64.7322 L 67.3705,64.7417 L 67.4194,64.7469 L 67.4685,64.748 L 67.5175,64.7448 L 67.5661,64.7375 L 67.6139,64.7259 L 67.6605,64.7104 L 67.7056,64.6908 L 67.7488,64.6675 L 67.7899,64.6405 L 67.8285,64.6101 L 67.8643,64.5765 L 67.8972,64.5399 L 67.9267,64.5007 L 67.9528,64.459 L 67.9752,64.4153 L 67.9938,64.3698 L 68.0084,64.3229 L 68.0189,64.2749 L 68.0252,64.2261 L 68.0273,64.1771 L 67.4562,64.1771 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity=1;stroke:#000000;stroke-width:2px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
</svg>
 [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
Abstract
本发明公开了一种治疗急性放射性皮炎的药物。包括内服药和外洗药，所述内服药由下述原料药制成：熟地黄、玄参、金银花、沙棘、山慈菇、鸡血藤、当归、乌梢蛇和甘草；所述外洗药由下述原料药制成：生地黄、蒲公英、苦参、龙胆草、牡丹皮、丹参、黄芩、黄柏、没药和艾叶。本发明采用内服药滋阴养血，清热凉血，解毒透疹，促进创面血液循环，活血通络；采用外洗药清热燥湿，抑菌抗菌，抑制创面污染，将坏死组织溶解化，改善局部血压循环，促进肉芽的生长。
Description
技术领域
[0001] 本发明涉及一种治疗急性放射性皮炎的药物，属于中药技术领域。
背景技术
[0002] 放射性皮炎(ad1dermatitis)是由于各种电离辐射包括X线射线以及放射性同位素照射皮肤、黏膜引起的炎症性损害。随着对放射线的认识及防护手段的提高，人们对此类疾病的警觉性已有了很大程度的提高，但随着放射线应用于医学诊断及治疗的不断普及，以及原子能工业的不断发展，人群接触放射线的机会不断增加，因此本病有增加趋势。
[0003] 急性放射性皮炎为短期内接受大剂量放射线所致，一般分为三度:
[0004] —度:以境界清楚的局限性红斑、水肿为主，伴有灼痛及瘙痒感。于3〜4周内逐渐消退，出现脱肩，遗留色素沉着和暂时性或永久性毛发脱落。
[0005] 二度:病变更为明显，除红斑、水肿外，还可出现水疱、糜烂或浅表溃疡，一般于I〜3个月内自行愈合。愈后可留有色素沉着、色素脱失、毛细血管扩张、皮肤萎缩、永久性毛发脱失、瘢痕形成和汗腺功能障碍等。
[0006] 三度:局部红肿严重，很快出现组织坏死，形成溃疡，病变可延伸至皮下组织、骨和内脏。具有潜行边缘和干燥基底的凿缘状“放射性溃疡”可持续数年和发生恶变。此种溃疡可伴剧痛。若痊愈后可形成萎缩性瘢痕，并可有色素沉着，色素脱失，毛发消失及毛细血管扩张等继发损害。
[0007]目前，常用的治疗急性放射性皮炎的方法为外用扑粉、炉甘石洗剂及龙胆紫外涂等。治疗效果不佳。
发明内容
[0008] 本发明克服了上述现有技术的不足，提供了一种治疗急性放射性皮炎的药物。该中药膏剂以纯中药组方，可有效治疗急性放射性皮炎。
[0009] 本发明的技术方案是:一种治疗急性放射性皮炎的药物，其特征是，包括内服药和外洗药，
[0010] 所述内服药由下述重量的原料药制成:熟地黄25-30克、玄参10-15克、金银花15-20克、沙棘15-20克、山慈菇10-15克、鸡血藤8_12克、当归8_12克、乌梢蛇10-15克和甘草3-8克。
[0011] 所述外洗药由下述重量的原料药制成:生地黄15-20克、蒲公英10-15克、苦参10-15克、龙胆草10-15克、牡丹皮10-15克、丹参10-15克、黄芩8-12克、黄柏8-12克、没药10-15克和艾叶8-12克。
[0012] 优选地:
[0013] 所述内服药由下述重量的原料药制成:熟地黄30克、玄参15克、金银花15克、沙棘20克、山慈菇12克、鸡血藤10克、当归10克、乌梢蛇12克和甘草5克。
[0014] 所述外洗药由下述重量的原料药制成:生地黄20克、蒲公英12克、苦参15克、龙胆草10克、牡丹皮15克、丹参10克、黄芩10克、黄柏10克、没药12克和艾叶10克。
[0015] 配制及服用方法:内服药水煎煮，分两次早晚服用；外洗药水煎煮，煎煮液清洗患处，分三次使用，使用时保持温度在30-40°C。5天为I个疗程。
[0016] 各中药的药理作用:
[0017] 熟地黄:甘，微温。归肝、肾经。功能与主治:补血滋阴，益精填髓。用于血虚萎黄，心悸怔忡，月经不调，崩漏下血，肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，眩晕，耳鸣，须发早白。
[0018]玄参:甘、苦、咸，微寒。归肺、胃、肾经。功能与主治:清热凉血，滋阴降火，解毒散结。用于热入营血，温毒发斑，热病伤阴，舌绛烦渴，津伤便秘，骨蒸劳嗽，目赤，咽痛，白喉，瘰疬，痈肿疮毒。
[0019] 金银花:清热解毒。治温病发热，热毒血痢，痈疡，肿毒，瘰疬。外用可消炎散痈、清热解毒。治痈疽、肿毒、疮癣、痈肿疔疮、肠痈肺痈等。
[0020] 沙棘:酸、湿，温。功能与主治:止咳祛痰，消食化滞，活血散瘀。用于咳嗽痰多，消化不良，食积腹痛，瘀血经闭，跌扑瘀肿。
[0021] 山慈菇:甘，微辛，寒。入肝、脾经。消肿，散结，化痰，解毒。治痈疽疔肿，瘰疬，喉痹肿痛，蛇、虫、狂犬伤。
[0022] 鸡血藤:苦、微甘，温；归肝经。功能与主治:补血活血，通经活络。本品气味柔和，走守兼备，能化阴生血，温通经脉，活血通络，推陈致新，有润而不燥、补而不滞，行而补破之特点，对血虚所致之风湿痹痛，淤滞疼痛及妇科诸证，均有良效。
[0023] 当归:甘、辛，温。归肝、心、脾经。功能与主治:补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
[0024] 乌梢蛇:甘，平。归肝经。功能与主治:祛风，通络，止痉。用于风湿顽痹，麻木拘挛，中风口眼歪斜，半身不遂，抽搐痉挛，破伤风，麻风疥癣，瘰疬恶疮。
[0025] 甘草:甘，平。归心、肺、脾、胃经。功能与主治:补脾益气，滋咳润肺，缓急解毒，调和百药。主治咽喉肿痛，痛疽疮疡，胃肠道溃疡以及解药毒、食物中毒等。
[0026] 生地黄:清热凉血，养阴生津。用于热入营血，温毒发斑，吐血衄血，热病伤阴，舌绛烦渴，津伤便秘，阴虚发热，骨蒸劳热，内热消渴。
[0027] 蒲公英:清热解毒，利尿散结。治急性结膜炎，感冒发热，急性扁桃体炎。蒲公英外科多用，取其清热解毒，散结消肿，能散滞气，通乳汁。
[0028] 苦参:苦，寒。归心、肝、胃、大肠、膀胱经。功能与主治:清热燥湿，杀虫，利尿。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风，外治滴虫性阴道炎。
[0029] 龙胆草:苦，寒。归肺、肝经。功能与主治:清热化痰，止咳平喘，解毒利湿，凉血止血。用于肺热咳嗽，痰多气喘，咽痛，口疮，湿热黄疸，衄血，便血，崩漏，外伤出血。
[0030] 牡丹皮:苦、辛，微寒。归心、肝、肾经。功能与主治:清热凉血，活血化瘀。用于热人营血，温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，跌扑伤痛，痈肿疮毒。
[0031] 丹参:苦，微寒。归心、肝经。功能与主治:活血祛瘀，通经止痛，清心除烦，凉血消痈。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
[0032] 黄芩:苦，寒。归肺、胆、脾、大肠、小肠经。功能与主治:清热燥湿，泻火解毒，止血，安胎。用于湿温、暑湿，胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
[0033] 黄柏:苦，寒。归肾、膀胱经。功能与主治:清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸尿赤，带下阴痒，热淋涩痛，脚气痿蹙，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹湿疮。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。
[0034] 没药:为橄榄科植物地丁树或哈地丁树的干燥树脂，又名末药。味苦，性平，归心、肝、脾经。具有活血止痛、消肿生肌之功。现代药理研究证实，没药有止痛，降低血浆纤维蛋白原，抑菌作用。
[0035] 艾叶:辛、苦，温；有小毒。归肝、脾、肾经。功能与主治:温经止血，散寒止痛。夕卜用祛湿止痒。用于吐血，衄血，崩漏，月经过多，胎漏下血，少腹冷痛，经寒不调，宫冷不孕；夕卜治皮肤瘙痒。醋艾炭温经止血，用于虚寒性出血。
[0036]中医认为:放射性引起的皮肤粘膜损失是由于热邪伤阴引起蓄发脱肩、热痒、溃疡，热血产生红斑，血瘀至色素沉着，气血凝滞，经络阻塞。本发明采用内服药滋阴养血，清热凉血，解毒透疹，促进创面血液循环，活血通络；采用外洗药清热燥湿，抑菌抗菌，抑制创面污染，将坏死组织溶解化，改善局部血压循环，促进肉芽的生长。内服药和外洗药配合使用，从而达到有效治疗急性放射性皮炎的目的。
[0037] 本发明的有益效果是:以纯中药组方，可以有效治疗急性放射性皮炎。自2011.3-2012.3，对67例癌症放疗患者所致的急性放射性皮炎采用本发明内服加外洗的方式进行治疗，治愈65例，治愈率为97.0%。
[0038] 典型病例:
[0039] 病例1:王某，女，63岁。患者2011.3诊断为宫颈癌，遂进行放射治疗，剂量为6000CGY，放疗后患者皮肤出现红斑、水肿及水疱，诊断为急性放射性皮炎(二度)，采用本发明内服加外洗的方式治疗，2个疗程后完全治愈。
[0040] 病例2:李某，女，58岁。患者2011.5诊断为右下肢股骨软组织肉瘤，术后进行放疗，在放射治疗过程中出现大面积的放射性皮炎(三度)，即皮肤破溃，疼痛难忍，不能入眠。经采用本发明内服加外洗的方式治疗，3个疗程后完全治愈。
[0041] 病例3:姜某，男，68岁。患者2012.2诊断为食道癌，由于患者年龄较大，采用保守放射治疗，剂量为4000CGY，放疗后患者皮肤出现浅表性溃疡，诊断为急性放射性皮炎(二度)，采用本发明内服加外洗的方式治疗，2个疗程后完全治愈。
具体实施方式
[0042] 实施例1
[0043] 内服药由下述重量的原料药制成:熟地黄30克、玄参15克、金银花15克、沙棘20克、山慈菇12克、鸡血藤10克、当归10克、乌梢蛇12克和甘草5克。
[0044] 外洗药由下述重量的原料药制成:生地黄20克、蒲公英12克、苦参15克、龙胆草10克、牡丹皮15克、丹参10克、黄芩10克、黄柏10克、没药12克和艾叶10克。
[0045] 配制及服用方法:内服药水煎煮，分两次早晚服用；外洗药水煎煮，煎煮液清洗患处，分三次使用，使用时保持温度在30-40°C。5天为I个疗程。
[0046] 实施例2
[0047] 内服药由下述重量的原料药制成:熟地黄25克、玄参10克、金银花15克、沙棘15克、山慈菇10克、鸡血藤8克、当归8克、乌梢蛇10克和甘草3克。
[0048] 外洗药由下述重量的原料药制成:生地黄20克、蒲公英15克、苦参15克、龙胆草15克、牡丹皮15克、丹参15克、黄芩12克、黄柏12克、没药15克和艾叶12克。
[0049] 配制及服用方法:同实施例1。
[0050] 实施例3
[0051] 内服药由下述重量的原料药制成:熟地黄30克、玄参15克、金银花20克、沙棘20克、山慈菇15克、鸡血藤12克、当归12克、乌梢蛇15克和甘草8克。
[0052] 外洗药由下述重量的原料药制成:生地黄15克、蒲公英10克、苦参10克、龙胆草10克、牡丹皮10克、丹参10克、黄芩8克、黄柏8克、没药10克和艾叶8克。
[0053] 配制及服用方法:同实施例1。
Claims (2)
1.一种治疗急性放射性皮炎的药物，其特征是，由内服药和外洗药组成， 所述内服药由下述重量的原料药制成:熟地黄25-30克、玄参10-15克、金银花15-20克、沙棘15-20克、山慈菇10-15克、鸡血藤8-12克、当归8-12克、乌梢蛇10-15克和甘草3-8克，水煎煮； 所述外洗药由下述重量的原料药制成:生地黄15-20克、蒲公英10-15克、苦参10-15克、龙胆草10-15克、牡丹皮10-15克、丹参10-15克、黄芩8_12克、黄柏8_12克、没药10-15克和艾叶8-12克，水煎煮。
2.如权利要求1所述的一种治疗急性放射性皮炎的药物，其特征是， 所述内服药由下述重量的原料药制成:熟地黄30克、玄参15克、金银花15克、沙棘20克、山慈菇12克、鸡血藤10克、当归10克、乌梢蛇12克和甘草5克，水煎煮； 所述外洗药由下述重量的原料药制成:生地黄20克、蒲公英12克、苦参15克、龙胆草10克、牡丹皮15克、丹参10克、黄芩10克、黄柏10克、没药12克和艾叶10克，水煎煮。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410089022.XA CN103800686B (zh) | 2014-03-12 | 2014-03-12 | 一种治疗急性放射性皮炎的药物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410089022.XA CN103800686B (zh) | 2014-03-12 | 2014-03-12 | 一种治疗急性放射性皮炎的药物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103800686A CN103800686A (zh) | 2014-05-21 |
| CN103800686B true CN103800686B (zh) | 2016-01-06 |
Family
ID=50698381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410089022.XA CN103800686B (zh) | 2014-03-12 | 2014-03-12 | 一种治疗急性放射性皮炎的药物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103800686B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104431406A (zh) * | 2014-09-30 | 2015-03-25 | 全椒县大地种植专业合作社 | 一种预防兔子脚皮炎的饲料添加剂 |
| CN104491113A (zh) * | 2014-12-25 | 2015-04-08 | 夏吉凯 | 一种治疗放射性皮炎的中药 |
| CN104587214A (zh) * | 2015-01-19 | 2015-05-06 | 滨州医学院附属医院 | 一种预防肺癌放疗引起的放射性皮炎的中药 |
| CN104645038A (zh) * | 2015-01-23 | 2015-05-27 | 黄显玉 | 一种防治胸壁放射性皮炎的中药组合物及其制备方法 |
| CN104587253A (zh) * | 2015-01-23 | 2015-05-06 | 黄显玉 | 一种防治头颈部放射性皮炎的中药组合物及其制备方法 |
| CN104623313A (zh) * | 2015-02-02 | 2015-05-20 | 青岛大学附属医院 | 一种防治放射性皮炎的中药组合物 |
| CN105213632A (zh) * | 2015-09-07 | 2016-01-06 | 肖斌 | 一种治疗特罗凯所致药物性皮疹的外洗剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011564A (zh) * | 2007-02-14 | 2007-08-08 | 张坚 | 治疗汗疱疹、带状疱疹及神经性皮炎的药物及其制备方法 |
| CN101961449A (zh) * | 2010-09-21 | 2011-02-02 | 王继尧 | 一种治疗体癣病的中药 |
| CN102416127A (zh) * | 2011-12-09 | 2012-04-18 | 崔国志 | 一种治疗牛皮癣的中药散剂 |
-
2014
- 2014-03-12 CN CN201410089022.XA patent/CN103800686B/zh not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011564A (zh) * | 2007-02-14 | 2007-08-08 | 张坚 | 治疗汗疱疹、带状疱疹及神经性皮炎的药物及其制备方法 |
| CN101961449A (zh) * | 2010-09-21 | 2011-02-02 | 王继尧 | 一种治疗体癣病的中药 |
| CN102416127A (zh) * | 2011-12-09 | 2012-04-18 | 崔国志 | 一种治疗牛皮癣的中药散剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103800686A (zh) | 2014-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101791377B (zh) | 一种用于宫颈炎、宫颈肥大术后康复的中药制剂 | |
| CN102357146B (zh) | 一种治疗脚气的中药 | |
| CN103550517B (zh) | 一种治疗肝癌的药物 | |
| CN102526616B (zh) | 一种治疗胆囊炎和胆结石的中草药丸 | |
| CN100417403C (zh) | 治疗癌症的中药 | |
| CN105327296A (zh) | 一种治疗消化性溃疡的药物及其制备方法 | |
| CN102671129B (zh) | 一种治疗宫颈癌的中药组合物 | |
| CN102920955B (zh) | 治疗脚气的外用中药组合物、制备方法和应用 | |
| CN101129717A (zh) | 一种外用治疗痔疮的中药组合物 | |
| CN100571754C (zh) | 一种治疗水火油烫伤及皮肤损伤的外用药物及其制备方法 | |
| CN102988852B (zh) | 一种治疗脚气的药物及其制备方法 | |
| CN103536888A (zh) | 一种治疗慢性盆腔炎的药物及其制备方法 | |
| CN103656127A (zh) | 一种治疗牙周炎的中药 | |
| CN103494958B (zh) | 一种治疗妇科炎症的中药洗液及制备方法 | |
| CN104324338A (zh) | 一种褥疮用护理贴 | |
| CN104225138A (zh) | 一种通过内服外洗治疗褥疮的中药及其制备方法 | |
| CN104324328A (zh) | 一种用于肠梗阻的中药组合物及其制备方法 | |
| CN104524337A (zh) | 一种治疗口腔溃疡的中药 | |
| CN102091290B (zh) | 一种治疗皮肤血管瘤的中药组合物 | |
| CN103623182B (zh) | 一种治疗妇科炎症的药物及其制备方法 | |
| CN105194542A (zh) | 跌打中药酒 | |
| CN104740458A (zh) | 一种治疗皮肤瘙痒的中药组合物 | |
| CN102973822A (zh) | 一种治疗口臭的药物及其制备方法 | |
| CN104189783A (zh) | 一种治疗口腔溃疡的中药 | |
| CN102018836B (zh) | 治疗混合痔疮的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160106 Termination date: 20190312 |