CN103800579A - Traditional Chinese medicinal composition for treating chronic rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating chronic rhinitis and preparation method thereof Download PDFInfo
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- CN103800579A CN103800579A CN201310704976.2A CN201310704976A CN103800579A CN 103800579 A CN103800579 A CN 103800579A CN 201310704976 A CN201310704976 A CN 201310704976A CN 103800579 A CN103800579 A CN 103800579A
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating chronic rhinitis and a preparation method thereof. The composition is prepared from roasted liquorice, ephedra, calamus, angelica root, magnolia flower, fructus psoraleae and schisandra chinensis. The invention also provides a preparation method of the traditional Chinese medicinal composition for treating chronic rhinitis. The composition has the effects of clearing heat and diminishing inflammation, expelling wind and promoting restoration of consciousness, has the advantages of exact curative effect, good safety and no side effect when being used for treating repeatedly attacking chronic rhinitis.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition for the treatment of chronic rhinitis and preparation method thereof.
Background technology
Chronic rhinitis is the chronic inflammatory disease of nasal mucosa and Submucosa.Its main feature is that inflammation continues above or outbreak repeatedly in three months, protracted course of disease, and the intermission also can not recover normally, and without clear and definite pathogenic microorganism, with nasal obstruction in various degree, secretions increase, tunica mucosa nasi swelling or the obstacle such as thicken.According to the degree of the pathology of chronic rhinitis and dysfunction, can be divided into chronic simple rhinitis and chronic hypertrophic rhinitis, the two cause of disease is identical, and is developed, is transformed by the former more than the latter, there is no absolute bound in histopathology, often has transitional type to exist.
Common method for the treatment of has:
1, topical therapeutic
(1) local glucocorticoid nasal spray;
(2) Decongestant: naphcon class Decongestant (naphazoline) is easy to cause medicamentous rhinitis and nasal mucosa is caused to irreversible damage, should be cautious use of.
(3) block therapy: can do fragrant cave and the sealing of BITONG cave; Also can make agger nasi or bilateral concha nasalis inferior leading portion submucosal injection.But this kind of method seldom application at present.
(4) acupuncture and moxibustion treatment: acupuncture fragrant cave and BITONG cave.
(5) for the too sticky person of nasal secretion, can apply the warm saline nasal irrigation of sterilization.
2, systemic drug treatment
(1) if inflammation is obvious and with more secretions refluence, can consider low-dose Oral macrolide antibiotics, i.e. the half of routine dose, continuous application 1～3 month.
(2) Chinese patent drugs for treatment: also can consider to apply the Chinese patent medicine such as HUODAN WAN, Fructus Xanthii.
3, operative treatment
For medicine and other patients who fails to respond to any medical treatment and have a stuffy nose with obvious persistence, feasible operative treatment.Operation is at present many to be carried out under nasal endoscope, can improve operation safety and accuracy.
(1) inferior turbinectomy;
(2) low-temperature plasma, laser (CO2 laser, YAG laser etc.), microwave inferior turbinate operations;
(3) inferior turbinectomy.
At present the method for the treatment of chronic rhinitis is of a great variety, does not have a kind of method can be adapted to all patients, need be for the medication of suiting the medicine to the illness of different patient body situations.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic rhinitis;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of chronic rhinitis.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition for the treatment of chronic rhinitis of the present invention is to be prepared from by the raw material containing following weight portion:
Radix Glycyrrhizae Preparata 2-8 part, Herba Ephedrae 7-15 part, Rhizoma Acori Graminei 10-20 part, Radix Angelicae Dahuricae 6-15 part, Flos Magnoliae 6-15 part, Fructus Psoraleae 10-20 part, Fructus Schisandrae Chinensis 10-20 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Radix Glycyrrhizae Preparata 3-6 part, Herba Ephedrae 8-11 part, Rhizoma Acori Graminei 12-16 part, Radix Angelicae Dahuricae 8-11 part, Flos Magnoliae 8-12 part, Fructus Psoraleae 12-17 part, Fructus Schisandrae Chinensis 12-17 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
5 parts of Radix Glycyrrhizae Preparata, 10 parts, Herba Ephedrae, 15 parts of Rhizoma Acori Gramineis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Flos Magnoliae, 15 parts of Fructus Psoraleae, 15 parts of Fructus Schisandrae Chinensis.
Below crude drug source of the present invention:
Radix Glycyrrhizae Preparata is the Root and Rootstock of pulse family glycyrrhiza genus Radix Glycyrrhizae Glycyrrhiza uralensis Fisch..Wild product are excavated autumn, and cultivation product, after sowing 3～4 years, are excavated in the fall, remove residual stem, dry respectively by thickness.Extracting liquorice sheet, add cooked Mel and boiled water a little, mix thoroughly, slightly vexed, put pot in slow fire fry to become buff, tack-free for degree, taking-up cools.
Herba Ephedrae: Ephedra sinica Ephedra sinica Stapf, claims again Herba Ephedrae, magnificent Herba Ephedrae.Ephedraceae, Ephedra.Attach most importance to and want medicinal plants, alkaloid is abundant, is the Main Resources that extracts ephedrine.Relieving asthma, antitussive, removes expectorant, diaphoresis, and diuresis, antiinflammatory, antipyretic, excited maincenter.
Rhizoma Acori Graminei: Latin literary fame Acorus calamus. plant kingdom; Angiospermae; Monocotyledonae; Arales; Araeceae; Acorus; Rhizoma Acori Graminei kind.Can dirtyly have one's ideas straightened out for warding off, a surname's gas, by expectorant, detoxifies, parasite killing.Control demented, infantile convulsion, coma due to phlegm syncope, anemofrigid-damp arthralgia, mouthful fulminant dysentery of keeping silent, external application carbuncle scabies.Have one's ideas straightened out, reduce phlegm, stomach invigorating., chronic bronchitis vexed for epilepsy, expectorant febrile convulsion, breast abdominal distention.
The Radix Angelicae Dahuricae: be the samphire Xingan Radix Angelicae Dahuricae (praying the Radix Angelicae Dahuricae) (Angelica dahurica Benth. et Hook.), storehouse and the Radix Angelicae Dahuricae (angelica anomala) (A.anomala La11.) and Radix angelicae dahuricae (Radix Angelicae Dahuricae (Radix Heraclei Scabridi)) (A.taiwaniana Boiss., epith.mut.), be used as medicine with root, the functions such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leucorrhea with red and white discharge, pain furuncle and phyma poison, also can make spice.
Flos Magnoliae: having another name called flos magnoliae, Flos Magnoliae, Magnolia denudata Desr., Flos Magnoliae Liliflorae, Magnolia liliiflora, cajaput, Yutang spring, is the alabastrum of Magnoliaceae defoliation bush plant Flos Magnoliae.Acrid in the mouth warm in nature, attach to the lung and stomach meridians.Because its pungent loose temperature is logical, fragrance is walked to alter, up women's head-ornaments, kind clearing the nasal passage, because controlling nasosinusitis headache key medicine.As long as its partially cold partial heat of suitable compatibility all can be applied, oral administration and externally has good curative effect simultaneously.
Fructus Psoraleae: be the fruit of legumes psoraleae.Convergence gods, can make heart born of the same parents' fire communicate with fire from the gater of life, therefore Yuanyang is firm, bone marrow is substantial, puckeryly take off also to control.Semen Juglandis is moisturized and nourishes blood, and blood pertaining to YIN is disliked dry, has the wonderful of wooden fiery interpromoting relation in five elements therefore oil to moisten it, is helped broken Fructus Psoraleae.
Fructus Schisandrae Chinensis: formal name used at school: Schisandra chinensis), call profound and, meeting and, five Fructus Armeniacae Mumes, Fructus Zanthoxyli Plansipini, strong taste, the five tastes etc., " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste " is carried in Tang etc. " Newly Revised Canon of Materia Medica ", therefore there is the name of Fructus Schisandrae Chinensis.List in the earliest Sheng Nong's herbal classic top grade, herbal function is the power of strengthening by means of tonics, and medical value is high, and bifendate, Bicyclol have hepatoprotective function.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole 7 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme two: get whole 7 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, leaves standstill 12-24 hour, filters, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme three: get whole 7 taste medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
The Chinese medicine composition for the treatment of chronic rhinitis of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active component, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active component, add granule to commonly use adjuvant, production method is prepared into granule of the present invention routinely.
The conventional adjuvant of above-mentioned granule comprises one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active component, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
A kind of Chinese medicine composition for the treatment of chronic rhinitis provided by the invention has the following advantages:
1, the Chinese medicine composition for the treatment of chronic rhinitis provided by the invention is safe and effective, has heat clearing and inflammation relieving, expelling pathogenic wind and restoring the functions of orifices in face effect, is 86.52% to chronic rhinitis total effective rate.
3, Chinese medicine composition composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
The specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
Embodiment 1 syrup
Get Radix Glycyrrhizae Preparata 5g, Herba Ephedrae 10g, Rhizoma Acori Graminei 15g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 15g.By above-mentioned 7 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, and merge extractive liquid, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water to stir, make syrup.
Embodiment 2 tablets
Get Radix Glycyrrhizae Preparata 3g, Herba Ephedrae 8g, Rhizoma Acori Graminei 12g, Radix Angelicae Dahuricae 8g, Flos Magnoliae 8g, Fructus Psoraleae 12g, Fructus Schisandrae Chinensis 12g.By above-mentioned 7 taste medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filters, the extractum that when filtrate concentrates 60 ℃, relative density is 1.25, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 3 mixture
Get Radix Glycyrrhizae Preparata 6g, Herba Ephedrae 11g, Rhizoma Acori Graminei 16g, Radix Angelicae Dahuricae 11g, Flos Magnoliae 12g, Fructus Psoraleae 17g, Fructus Schisandrae Chinensis 17g.By above-mentioned 7 taste medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.20, adds ethanol, and making containing alcohol amount is 40%, leave standstill 24 hours, filter, the extractum that when filtrate is concentrated into filtrate and is concentrated into 70 ℃, relative density is 1.10, adding purified water ad pond om is 3 times of medical material gross weight, fill, obtains mixture of the present invention.
Add mixture adjuvant sucrose, ethyl ester, water, sorbic acid to stir, make mixture.
Embodiment 4 tablets
Get Radix Glycyrrhizae Preparata 2g, Herba Ephedrae 7g, Rhizoma Acori Graminei 10g, Radix Angelicae Dahuricae 6g, Flos Magnoliae 6g, Fructus Psoraleae 10g, Fructus Schisandrae Chinensis 10g.By above-mentioned 7 taste medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid,, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 5 capsules
Get Radix Glycyrrhizae Preparata 8g, Herba Ephedrae 15g, Rhizoma Acori Graminei 20g, Radix Angelicae Dahuricae 15g, Flos Magnoliae 15g, Fructus Psoraleae 20g, Fructus Schisandrae Chinensis 20g.By above-mentioned 7 taste medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 6 granules
Get Radix Glycyrrhizae Preparata 5g, Herba Ephedrae 15g, Rhizoma Acori Graminei 12g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, Fructus Psoraleae 20g, Fructus Schisandrae Chinensis 15g.By above-mentioned 7 taste medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, and merge extractive liquid, filters, filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, add ethanol, making containing alcohol amount is 70%, leaves standstill 12 hours, filter, the extractum that when filtrate is concentrated into 70 ℃, relative density is 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, makes granule.
Embodiment 7 powder
Take Radix Glycyrrhizae Preparata 5g, Herba Ephedrae 10g, Rhizoma Acori Graminei 15g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 15g.Medical material cleans, pulverizes, and crosses 80-100 mesh sieve, obtains powder of the present invention.
Embodiment 8
The syrup that the embodiment of the present invention 1 is prepared, gives chronic rhinitis patient oral, each 50ml, and every day 3 times, clinical data is as follows:
| Disease disease classification | Disease number of cases | Disease year calendar | Treatment time | Efficiently individual quantity | Total effective rate |
| Chronic rhinitis | 89 people | 1-20 | 7-30 days | 77 people | 86.52% |
Embodiment 9
Chen, man, 45 years old.Patient suffers from chronic rhinitis more than 20 years, often rhinocnesmus, snivel, sneeze.Before one month, suddenly symptom increases the weight of, and sneeze is paid no attention to disconnected continuously, and nasal obstruction also increases the weight of, and needs mouth breathing, falls asleep that it is awake also can to suppress evening, impact life and having a rest, cisco unity malfunction.Through multiple treatment, be all interim alleviation at every turn, just recurrence again after circling well, after recurrence, symptom is as front.Give the embodiment of the present invention 6 granules, treat after 2 days, patient's sneeze number of times obviously reduces, nasal obstruction alleviates, and sleep in evening is no longer suppressed awake, continual cure 7 days, patient's symptom of having a stuffy nose is alleviated substantially, and sneeze obviously alleviates, and only beats several sneeze from room is gone back in open air time.Treat after 1 month patient patient's recovery from illness.Follow up a case by regular visits to not recurrence in eight months.
Although, above use general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. treat a Chinese medicine composition for chronic rhinitis, it is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Glycyrrhizae Preparata 2-8 part, Herba Ephedrae 7-15 part, Rhizoma Acori Graminei 10-20 part, Radix Angelicae Dahuricae 6-15 part, Flos Magnoliae 6-15 part, Fructus Psoraleae 10-20 part, Fructus Schisandrae Chinensis 10-20 part.
2. the Chinese medicine composition for the treatment of chronic rhinitis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Glycyrrhizae Preparata 3-6 part, Herba Ephedrae 8-11 part, Rhizoma Acori Graminei 12-16 part, Radix Angelicae Dahuricae 8-11 part, Flos Magnoliae 8-12 part, Fructus Psoraleae 12-17 part, Fructus Schisandrae Chinensis 12-17 part.
3. the Chinese medicine composition for the treatment of chronic rhinitis as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 5 parts of Radix Glycyrrhizae Preparata, 10 parts, Herba Ephedrae, 15 parts of Rhizoma Acori Gramineis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Flos Magnoliae, 15 parts of Fructus Psoraleae, 15 parts of Fructus Schisandrae Chinensis.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole 7 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole 7 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, leave standstill 12-24 hour, filter, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole 7 taste medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
8. treat a Chinese medicine composition for chronic rhinitis, comprise acceptable carrier in the Chinese medicine composition for the treatment of chronic rhinitis of any one in claim 1-3 and pharmaceuticals industry.
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| CN102018838A (en) * | 2010-11-15 | 2011-04-20 | 张英堂 | Medicine for treating chronic rhinitis |
| CN102205106A (en) * | 2011-05-20 | 2011-10-05 | 济南金鼎信息技术有限公司 | Chinese medicinal composition for treating allergic rhinitis |
| KR20110138082A (en) * | 2010-06-18 | 2011-12-26 | 한국 한의학 연구원 | Composition for immunopotentiating comprising the extract of herbal formula, ojeok-san |
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2013
- 2013-12-20 CN CN201310704976.2A patent/CN103800579A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110138082A (en) * | 2010-06-18 | 2011-12-26 | 한국 한의학 연구원 | Composition for immunopotentiating comprising the extract of herbal formula, ojeok-san |
| CN102018838A (en) * | 2010-11-15 | 2011-04-20 | 张英堂 | Medicine for treating chronic rhinitis |
| CN102205106A (en) * | 2011-05-20 | 2011-10-05 | 济南金鼎信息技术有限公司 | Chinese medicinal composition for treating allergic rhinitis |
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Application publication date: 20140521 |