CN103783049A - Sterilization composition containing prothioconazole and abamectin - Google Patents

Sterilization composition containing prothioconazole and abamectin Download PDF

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Publication number
CN103783049A
CN103783049A CN201410026786.4A CN201410026786A CN103783049A CN 103783049 A CN103783049 A CN 103783049A CN 201410026786 A CN201410026786 A CN 201410026786A CN 103783049 A CN103783049 A CN 103783049A
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China
Prior art keywords
bactericidal composition
prothioconazoles
avermectin
active component
weight
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CN201410026786.4A
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Chinese (zh)
Inventor
杨征宇
张志峰
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浙江泰达作物科技有限公司
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Priority to CN201410026786.4A priority Critical patent/CN103783049A/en
Publication of CN103783049A publication Critical patent/CN103783049A/en

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Abstract

The invention discloses a sterilization composition containing prothioconazole and abamectin. The sterilization composition contains effective active components, namely, prothioconazole and abamectin with a weight ratio of 60:1-1:60. The sterilization composition at least contains a surfactant so that the active components are favorably dispersed in water when being applied. The sterilization composition disclosed by the invention integrates protection, therapy and deactivating, and can be used in multiple crops such as cereal crops, legume crops, oilseed rape, peanuts, coffee and fruit trees, and used for controlling powdery mildew, rust disease, white rot, brown leaf rust, stripe rust, glume blight, leaf mold, banded sclerotial blight, blight, leaf spot disease, stalk break, net blotch, gray mold, and the like.

Description

A kind of bactericidal composition containing prothioconazoles and Avermectin

Technical field

The present invention relates to a kind of agricultural chemicals, especially a kind of preparation of the bactericidal composition containing prothioconazoles and Avermectin and application.

Background technology

Prothioconazoles, English common name (prothioconazole), molecular formula: C 14h 15c 12n 3oS, chemical name: (RS)-2-[2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl]-2,4-dihydro-1,2,4-triazole-3-thioketones.A kind of new triazolinones systemic fungicide of prothioconazoles, as a kind of demethylation enzyme inhibitor (DMI), plays precursor-lanosterol demethylation effect on 14-or 24 methylene lanostenols of sterol in Antifungi.By a large amount of field control effectiveness tests, result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase obviously, compares with triazole bactericidal agent, and prothioconazoles has the more bactericidal activity of wide spectrum, and the lasting period is long.

Avermectin, English common name (Abamectin), molecular formula: C 48h 72o 14(B1a) C 47h 70o 14(B1b).Avermectin has stomach toxicity and action of contace poison to mite class and insect, can not ovicidal.What mechanism of action was different from general insecticide is to disturb neurophysiology activity, stimulate and discharge γ-aminobutyric acid, and aminobutyric acid has inhibitory action to arthropodan nerve conduction.There is paralysis symptom after contacting with Avermectin with insect larvae in mite class adult, nymph, inertia, does not take food, dead after 2~4 days.Because not causing that insect dewaters rapidly, so Avermectin lethal effect is slower.Though Avermectin has direct action of contace poison to insect predator and insect parasite, because plant surface is residual few, therefore very little to the damage of beneficial insect.Avermectin can not be moved by adsorption by soil in soil, and decomposed by microorganism, thereby in environment without cumulative function, can be used as a part of integrated control.Modulation easily, by stirring and can use a little in the preparation water of falling people, also safer to crop.

At present, prothioconazoles and Avermectin composite and being applied in both at home and abroad not yet disclosed.

Summary of the invention

The object of the invention is a kind ofly can to prevent the generation of disease drug resistance or delay pesticide resistance speed in order to propose the bactericidal composition containing prothioconazoles and Avermectin that use cost is low, preventive effect is good.The present invention is achieved through the following technical solutions:

The bactericidal composition that the present invention proposes contains A, two kinds of active components of B.

Active component A is prothioconazoles.

Active component B is Avermectin.

The ratio of weight and number of A, two kinds of active components of B is 60:1~1:60, and preferred ratio of weight and number is 30:1~1:30, and preferred ratio of weight and number is: 10:1~1:10.

The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in bactericidal composition, the weight percentage of active component A and B is gross weight 0.1~90%, is preferably 1%~60%.According to different preparation types, active component content scope is different.Conventionally, the liquid preparation that bactericidal composition is made contains 0.1~70% active component by weight, is preferably 0.8~50%; The solid pharmaceutical preparation that bactericidal composition is made contains 0.1~85% active component by weight, is preferably 0.8~50%.

In bactericidal composition of the present invention, contain a kind of active ingredient, wherein at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5~30% of active ingredient gross weight, and surplus is solid or liquid diluent.

The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, emulsifier or defoamer.According to different dosage form, in active ingredient, can also contain disintegrant known in those skilled in the art, antifreeze etc.

Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its configuration can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc.

Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand, and wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, seed treatment.

Bactericidal composition of the present invention has protection concurrently, treats and roots out activity; can be used for various crop; as: the crops such as cereal crop, legume crop, rape, peanut, coffee and fruit tree, preventing and treating powdery mildew, rust, white rot, leaf rust, yellow rust, glume blight, leaf mold, banded sclerotial blight, fusarium wilt, leaf spot, stalk break, net blotch, gray mold all has fabulous activity.

Bactericidal composition of the present invention has following advantage:

(1) this bactericidal composition shows significant synergistic effect in certain ratio range, has both improved protection effect, has reduced mu dosage and cost, has expanded again fungicidal spectrum;

(2) because each active component in this bactericidal composition does not exist the problem of cross resistance, so, the application of this bactericidal composition can reach and delay the drug-fast generation of pathogen and development, and the result of use that contributes to extend this medicament reduces pesticide resistance and produces probability;

(3) improved safety, mixture will be lower on the impact of environment, safer.

Embodiment

Below by specific embodiment, the invention will be further described, but the present invention is not limited by following examples.

The bactericidal composition that the present invention proposes contains A, two kinds of active components of B.

Active component A is prothioconazoles.

Active component B is Avermectin.

The ratio of weight and number of A, two kinds of active components of B is 60:1~1:60, and preferred ratio of weight and number is 30:1~1:30, and preferred ratio of weight and number is: 10:1~1:10.

The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in bactericidal composition, the weight percentage of active component A and B is gross weight 0.1~80%, is preferably 1%~60%.According to different preparation types, active component content scope is different.Conventionally, the liquid preparation that bactericidal composition is made contains 0.1~70% active component by weight, is preferably 0.8~50%; The solid pharmaceutical preparation that bactericidal composition is made contains 0.1~85% active component by weight, is preferably 0.8~50%.

In bactericidal composition of the present invention, contain a kind of active ingredient, wherein at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5~30% of active ingredient gross weight, and surplus is solid or liquid diluent.

The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, emulsifier or defoamer.According to different dosage form, in preparation, can also contain disintegrant known in those skilled in the art, antifreeze etc.

Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its configuration can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc.

Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand, and wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, seed treatment.

When making wetting powder, bactericidal composition comprises following constituent content: active component A 1~60%, active component B1~60%, dispersant 5~10%, wetting agent 2~10%, filling supply 100%.

Active component A, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.

Wetting powder the key technical indexes of the present invention:

When making water dispersible granules, bactericidal composition comprises following constituent content: active component A 1~60%, active component B1~60%, dispersant 3~13%, wetting agent 1~6%, disintegrant 1~10%, binding agent 1~6%, filling supply 100%.

By mixing such as active component A, active component B, dispersant, wetting agent, disintegrant, fillers, be crushed to through airslide disintegrating mill the particle diameter needing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, can be made into water dispersible granules product of the present invention.

Water dispersible granules the key technical indexes of the present invention:

When making suspending agent, bactericidal composition comprises following constituent content: active component A 1~40%, active component B1~40%, dispersant 2~12%, wetting agent 2~10%, defoamer 0.1~1.2%, thickener 0.1~2%, antifreeze 0.1~9%, deionized water add to 100%.

Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add active component A, active component B, ball milling 2~3.5 hours in ball mill, makes diameter of particle all below 5 μ m, makes suspending agent product of the present invention.

Suspending agent the key technical indexes of the present invention:

When making aqueous emulsion, bactericidal composition comprises following constituent content: active component A 1~40%, active component B1~40%, solvent 1~30%, emulsifier 1~15%, co-emulsifier 0~6%, antifreeze 0~10%, thickener 0.1~2%, defoamer 0.01~2%, deionized water add to 100%.

Above-mentioned formulation material is mixed, active principle A, active principle B, solvent, emulsifier, co-emulsifier are added together, make to be dissolved into even oil phase; Water, defoamer, thickener, antifreeze are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.

Aqueous emulsion the key technical indexes of the present invention:

Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalenesulfonateformaldehyde formaldehyde amine condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, one or more in ester APEO.

Described wetting agent is selected from: one or more in lauryl sodium sulfate, sodium dodecylbenzenesulfonate, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.

Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, glucose, aluminium chloride.

Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.

Described defoamer is selected from: one or more in silicone, C8~10 aliphatic alcohols, C10~20 saturated fat acids and acid amides, silicone oil, silicone compound.

Described emulsifier is selected from one or more in alkyl benzene sulfonate calcium salt, styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, phenethyl phenol polyethenoxy ether, 506#, 600#, 700#, NP-10 phosphate, OP-10 phosphate, castor oil polyoxyethylene ether, sorbester p17, Tween 80,602#.

Described co-emulsifier is one or more in butanols, isobutanol, dodecanol-1, tetradecanol-1, octadecanol-1.

Described solvent is selected from one or more in toluene, dimethylbenzene, methyl alcohol, ethanol, acetone, ether, cyclohexanone, vegetable oil, dimethyl formamide, acetonitrile, polyethylene glycol, pyrrolidones, solvent N-chain alkyl pyrrolidones.

Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.

Bactericidal composition of the present invention has protection concurrently, treats and roots out activity; can be used for various crop; as: the crops such as cereal crop, legume crop, rape, peanut, coffee and fruit tree, preventing and treating powdery mildew, rust, white rot, leaf rust, yellow rust, glume blight, leaf mold, banded sclerotial blight, fusarium wilt, leaf spot, stalk break, net blotch, gray mold all has fabulous activity.

The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.

Toxicity Determination:

Prothioconazoles and abamectin compounded to target fungus Toxicity Determination.

Test medicine provides by crop Science and Technology Ltd. of Zhejiang Taida.

After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 meterings by active constituent content and is processed, and establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to target fungus.After 72h, measure colony diameter by right-angled intersection method, calculate net production, mycelial growth inhibition rate everywhere.

Net growth (mm)=measurement colony diameter-5

Mycelial growth inhibition rate is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value to (x), tries to achieve virulence regression equation (y=a=bx) with method of least squares, and calculates thus the EC of every kind of medicament 50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:

Wherein: a, b are respectively prothioconazoles and Avermectin shared ratio in composition:

A is prothioconazoles.

B is Avermectin.

Result of the test is as shown in the table:

Independent measurement result

Table 1 prothioconazoles and the abamectin compounded toxicity test analysis of results table to rice blast

As shown in Table 1, Avermectin, the EC of prothioconazoles to rice blast 50be respectively 0.33mg/L and 1.24mg/L.Avermectin, both mixtures within the scope of 60:1~1:60 of prothioconazoles all show obvious synergistic effect.Wherein, both mixed synergies within the scope of 30:1~1:30 are comparatively desirable, and within the scope of 10:1~1:10, mixed synergies is particularly outstanding.

Field control effectiveness test:

Scheme 1:

The 2% Avermectin prothioconazoles suspending agent control wheat powdery mildew test of pesticide effectiveness.

Avermectin 0.8%, prothioconazoles 1.2%, polycarboxylate 3%, lignosulfonates 3%, sodium dodecylbenzenesulfonate 4%, polyoxyethylene nonylphenol ether modified phosphate 3%, acetone 6%, xanthans 0.5%, propane diols 3%, deionized water add to 100%, mix and make 30% Avermectin prothioconazoles suspending agent.This proportioning is by 4000 times of dilution sprayings, in their early stage dispenser, after medicine, 3 days, 15 days, 30 days control wheat powdery mildew effects are respectively 93.27%, 97.56%, 92.47%, 1% abamectin emulsifiable concentrate and 3% prothioconazoles pulvis are according to same method, use by 3500 times and 2000 times of dilutions respectively, after medicine, 15 days preventive effects are respectively 73.7% and 71.1%.

Scheme 2:

1% Avermectin prothioconazoles seed treatment is processed wheat seed test.

Avermectin 0.5%, prothioconazoles 0.5%, polycarboxylate 3%, lignosulfonates 4%, sodium dodecylbenzenesulfonate 4%, xanthans 3%, polyvinyl acetate 3%, sodium dichlorophenol indophenol 2%, alkyl benzene sulfonate calcium salt 3%, deionized water add to 100%, mix and make 10% Avermectin prothioconazoles seed treatment.This proportioning is pressed 25g/100kg seed seed dressing, in closed container, seed dressing is mixed to 1 minute with seed jolting, then by planting seed to experimental field, and in one day laggard row man-made irrigation.After planting 28 days calculate preventive effect is 100%, does not observe and infects.Contrast medicament 1% abamectin emulsifiable concentrate and 3% prothioconazoles pulvis are used according to same method, within after planting 28 days, calculate preventive effect and are respectively 86.3% and 81.5%.

Above-described embodiment is only for the inventive concept of the present invention of explaining, but not restriction to rights protection of the present invention, allly utilizes this design to carry out the change of unsubstantiality to the present invention, all should fall into protection scope of the present invention.

Claims (8)

1. containing a bactericidal composition for prothioconazoles and Avermectin, it is characterized in that: bactericidal composition comprises active component A and B, the ratio of weight and number of active component A and B is 60:1~1:60, and described active component A is prothioconazoles; Active component B is Avermectin.
2. a kind of bactericidal composition containing prothioconazoles and Avermectin according to claim 1, is characterized in that: in bactericidal composition, the ratio of weight and number of active component A and B is 30:1~1:30.
3. the bactericidal composition of prothioconazoles according to claim 1 and Avermectin, is characterized in that: in bactericidal composition, the ratio of weight and number of active component A and B is 10:1~1:10.
4. according to claim 1 containing a kind of bactericidal composition containing prothioconazoles and Avermectin, it is characterized in that: in bactericidal composition, the weight percentage of active component A and B is gross weight 0.1%~90%.
5. a kind of bactericidal composition containing prothioconazoles and Avermectin according to claim 1, it is characterized in that: in bactericidal composition, contain a kind of active ingredient, wherein at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use; Surface-active contents is 5~30% of active ingredient gross weight.
6. a kind of bactericidal composition containing prothioconazoles and Avermectin according to claim 5, is characterized in that: described surfactant is one or more that are selected from dispersant, wetting agent, emulsifier or defoamer.
7. a kind of bactericidal composition containing prothioconazoles and Avermectin according to claim 1, it is characterized in that: bactericidal composition can be processed into acceptable formulation on any agricultural chemicals on demand, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, seed treatment.
8. a kind of bactericidal composition containing prothioconazoles and Avermectin according to claim 1, for crops such as cereal crop, legume crop, rape, peanut, coffee and fruit trees, prevent and treat powdery mildew, rust, white rot, leaf rust, yellow rust, glume blight, leaf mold, banded sclerotial blight, fusarium wilt, leaf spot, stalk break, net blotch, gray mold.
CN201410026786.4A 2014-01-21 2014-01-21 Sterilization composition containing prothioconazole and abamectin CN103783049A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104026136A (en) * 2014-06-16 2014-09-10 深圳诺普信农化股份有限公司 Agricultural fungicidal composition
CN106342841A (en) * 2016-08-26 2017-01-25 浙江海正化工股份有限公司 Pesticide composition, method for preparing same and application of pesticide composition
CN107535518A (en) * 2016-06-28 2018-01-05 四川利尔作物科学有限公司 Seed treatment composition and its application
CN107549190A (en) * 2016-07-01 2018-01-09 四川利尔作物科学有限公司 Seed treatment composition and its application
CN107771849A (en) * 2016-08-29 2018-03-09 四川利尔作物科学有限公司 Seed treatment composition and its application
CN107771850A (en) * 2016-08-29 2018-03-09 四川利尔作物科学有限公司 Seed treatment composition and its application

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104026136A (en) * 2014-06-16 2014-09-10 深圳诺普信农化股份有限公司 Agricultural fungicidal composition
CN107535518A (en) * 2016-06-28 2018-01-05 四川利尔作物科学有限公司 Seed treatment composition and its application
CN107549190A (en) * 2016-07-01 2018-01-09 四川利尔作物科学有限公司 Seed treatment composition and its application
CN106342841A (en) * 2016-08-26 2017-01-25 浙江海正化工股份有限公司 Pesticide composition, method for preparing same and application of pesticide composition
CN107771849A (en) * 2016-08-29 2018-03-09 四川利尔作物科学有限公司 Seed treatment composition and its application
CN107771850A (en) * 2016-08-29 2018-03-09 四川利尔作物科学有限公司 Seed treatment composition and its application

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