CN103751490B - A kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis - Google Patents

A kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis Download PDF

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CN103751490B
CN103751490B CN201410044290.XA CN201410044290A CN103751490B CN 103751490 B CN103751490 B CN 103751490B CN 201410044290 A CN201410044290 A CN 201410044290A CN 103751490 B CN103751490 B CN 103751490B
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medicinal composition
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water
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CN103751490A (en
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胡芳
张勤梅
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Qidong Jiulong shunzhou toy factory
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王雪雁
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Abstract

The invention discloses a kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis, said composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Lonicerae 21-25 part, Spica Prunellae 21-25 part, Radix Angelicae Dahuricae 30-34 part, Rhizoma Paridis 18-22 part, Radix Glycyrrhizae Preparata 12-17 part, Concha Arcae 30-34 part, Fructus Arctii 18-22 part, Borneolum Syntheticum 6-9 part.The pharmaceutical composition that the present invention relates to is with the mode administration of external, and medicine goes directly disease institute, rapid-action, avoids because the oral infant that causes is taken medicine difficulty and the not high problem of interdependence simultaneously.

Description

A kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis
Technical field
The present invention relates to a kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis, belong to field of Chinese herbal medicine technology.
Background technology
Cervical region acute lymphadenitis is the acute inflammatory disease occurring in cervical region both sides lymph node.The lighter is involved lymph nodes enlargement and local tenderness only; Comparatively severe one local red and swollen heat pain, often accompanies General Symptoms, as laryngopharynx swelling and pain, cough, heating etc.As inflammation extends to around lymph node, several lymph node adhesion is agglomerating, also can develop into abscess, have fluctuation, and local pain is aggravated, and even suppurates.
Cervical region acute lymphadenitis belongs to the category such as motherland's medical science " pathogenic wind-warm ", " sucutaneous nodule ", is diseases caused by exogenous pathogenic factor pathogenic wind-warm Shi Re Bing Pian, flees passages through which vital energy circulates, and stop up the few sun of resistance, bright two warps of sun, stagnation of QI-blood, pent-up issues as primary disease in jaw.Western medical treatment is generally based on oral antibiotic and antiviral agents, but the side effect of Long-term Oral Western medicine is larger; And the traditional Chinese medical science is generally based on the Chinese medicine for oral administration of removing heat-phlegm for oral administration, eliminating stasis and resolving masses, but clinically because child takes medicine difficult and compliance is poor, clinical effectiveness is not obvious.
In sum, by researching and developing a kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis, seem particularly urgent.
Summary of the invention
The object of the present invention is to provide a kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis.This pharmaceutical composition be on the basis of secret prescription handed down in the family from generation to generation improve and obtain, have evident in efficacy, spend low advantage, after many decades clinical practice, determine that it is a kind of specific medicament for the treatment of pediatric neck acute lymphadenitis.
The object of the present invention is achieved like this:
Treat an externally-applied medicinal composition for pediatric neck acute lymphadenitis, be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Lonicerae 21-25 part, Spica Prunellae 21-25 part, Radix Angelicae Dahuricae 30-34 part, Rhizoma Paridis 18-22 part, Radix Glycyrrhizae Preparata 12-17 part, Concha Arcae 30-34 part, Fructus Arctii 18-22 part, Borneolum Syntheticum 6-9 part.
In the present invention's most preferred embodiment, the externally-applied medicinal composition of described treatment pediatric neck acute lymphadenitis, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Lonicerae 23 parts, Spica Prunellae 23 parts, the Radix Angelicae Dahuricae 32 parts, Rhizoma Paridis 20 parts, Radix Glycyrrhizae Preparata 15 parts, Concha Arcae 32 parts, Fructus Arctii 20 parts, Borneolum Syntheticum 8 parts.
Preferably, the externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis as mentioned above, it can be made into ointment, liniment, gel.
The preparation method of the Chinese medicine ointment that the present invention relates to comprises the steps: the above-mentioned 7 taste Chinese crude drugs except Borneolum Syntheticum getting recipe quantity, cleans roguing, dries, be ground into granule; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-12 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, and 0 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take Borneolum Syntheticum, be ground into fine powder respectively, cross 100 eye mesh screens; Take stearic acid 16-22 part and liquid paraffin 85-110 part, put heated and stirred on water-bath and do oil phase to fine melt, Borneolum Syntheticum is put into oil phase and melts, about 70 DEG C insulations; Separately get glycerol 45-70 part, triethanolamine 4-6 part, distilled water 400-600 part, on water-bath, aqueous phase is done in heating, above-mentioned water extract-alcohol precipitation extractum is added in aqueous phase, 70 DEG C of insulations, oil phase is gently added in aqueous phase and ceaselessly stirs, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment of the present invention.
Traditional Chinese medicinal material raw materials of the present invention has following source: Flos Lonicerae is selected from the dry flower of caprifoliaceae plant Radix Ophiopogonis (Lonicera japonica Thunb).Spica Prunellae selects the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..The Radix Angelicae Dahuricae selects the dry root of samphire angelica anomala.Rhizoma Paridis selects the dry rhizome of liliaceous plant Rhizoma Paridis or RHIZOMA PARIDIS.Radix Glycyrrhizae Preparata is selected as dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome honey of Glycyrrhiza glabra L. G. glabra L. is smoked and obtains.Concha Arcae selects the shell of Carnis Arca inflata section animal Scapharca subcrenata Arca subcrenata Lischke.Fructus Arctii is selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..Borneolum Syntheticum is selected from the resin of Spore density Borneolum Syntheticum and the crystallization of volatile oil processed goods extraction acquisition.
Compared with prior art, the pharmaceutical composition that the present invention relates to is with the mode administration of external, and medicine goes directly disease institute, rapid-action, and relief of symptoms is better than conventional western medicine.In addition, adopt the administration of external mode, avoid because the oral infant that causes is taken medicine difficulty and the not high problem of interdependence.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
the preparation of embodiment 1 Chinese medicine ointment
By weight, take Flos Lonicerae 23 parts, Spica Prunellae 23 parts, the Radix Angelicae Dahuricae 32 parts, Rhizoma Paridis 20 parts, Radix Glycyrrhizae Preparata 15 parts, Concha Arcae 32 parts and Fructus Arctii 20 parts, clean roguing, dry, be ground into granule; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, and 0 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take Borneolum Syntheticum 8 parts, be ground into fine powder respectively, cross 100 eye mesh screens; Take stearic acid 20 parts and liquid paraffin 102 parts, put heated and stirred on water-bath and do oil phase to fine melt, Borneolum Syntheticum is put into oil phase and melts, about 70 DEG C insulations; Separately get glycerol 60 parts, triethanolamine 4.5 parts, distilled water 500 parts, on water-bath, aqueous phase is done in heating, adds in aqueous phase by above-mentioned water extract-alcohol precipitation extractum, 70 DEG C of insulations, gently add oil phase in aqueous phase and ceaselessly stir, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment.
the preparation of embodiment 2 Chinese medicine ointment
By weight, take Flos Lonicerae 25 parts, Spica Prunellae 25 parts, the Radix Angelicae Dahuricae 32 parts, Rhizoma Paridis 18 parts, Radix Glycyrrhizae Preparata 17 parts, Concha Arcae 32 parts and Fructus Arctii 18 parts, clean roguing, dry, be ground into granule; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, and 0 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take Borneolum Syntheticum 9 parts, be ground into fine powder respectively, cross 100 eye mesh screens; Take stearic acid 18 parts and liquid paraffin 95 parts, put heated and stirred on water-bath and do oil phase to fine melt, Borneolum Syntheticum is put into oil phase and melts, about 70 DEG C insulations; Separately get glycerol 60 parts, triethanolamine 5 parts, distilled water 550 parts, on water-bath, aqueous phase is done in heating, adds in aqueous phase by above-mentioned water extract-alcohol precipitation extractum, 70 DEG C of insulations, gently add oil phase in aqueous phase and ceaselessly stir, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment.
the preparation of embodiment 3 Chinese medicine ointment
By weight, take Flos Lonicerae 24 parts, Spica Prunellae 22 parts, the Radix Angelicae Dahuricae 30 parts, Rhizoma Paridis 22 parts, Radix Glycyrrhizae Preparata 13 parts, Concha Arcae 34 parts and Fructus Arctii 22 parts, clean roguing, dry, be ground into granule; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 12 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, and 0 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take Borneolum Syntheticum 8 parts, be ground into fine powder respectively, cross 100 eye mesh screens; Take stearic acid 22 parts and liquid paraffin 110 parts, put heated and stirred on water-bath and do oil phase to fine melt, Borneolum Syntheticum is put into oil phase and melts, about 70 DEG C insulations; Separately get glycerol 45 parts, triethanolamine 5 parts, distilled water 500 parts, on water-bath, aqueous phase is done in heating, adds in aqueous phase by above-mentioned water extract-alcohol precipitation extractum, 70 DEG C of insulations, gently add oil phase in aqueous phase and ceaselessly stir, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment.
the preparation of embodiment 4 Chinese medicine ointment
By weight, take Flos Lonicerae 21 parts, Spica Prunellae 21 parts, the Radix Angelicae Dahuricae 34 parts, Rhizoma Paridis 20 parts, Radix Glycyrrhizae Preparata 12 parts, Concha Arcae 30 parts and Fructus Arctii 22 parts, clean roguing, dry, be ground into granule; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, and 0 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take Borneolum Syntheticum 7 parts, be ground into fine powder respectively, cross 100 eye mesh screens; Take stearic acid 22 parts and liquid paraffin 88 parts, put heated and stirred on water-bath and do oil phase to fine melt, Borneolum Syntheticum is put into oil phase and melts, about 70 DEG C insulations; Separately get glycerol 60 parts, triethanolamine 6 parts, distilled water 500 parts, on water-bath, aqueous phase is done in heating, adds in aqueous phase by above-mentioned water extract-alcohol precipitation extractum, 70 DEG C of insulations, gently add oil phase in aqueous phase and ceaselessly stir, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment.
embodiment 5 clinical practice example
43 routine acute submaxillary lymphadenitis infants, wherein man 19 example, female 24 example; 7 years old age-l4 year; Course of disease 1d-5d.Be divided into test group (22 example) and matched group (21 example) at random, two groups do not have significant difference, have comparability in sex, age, the course of disease etc.Test group infant is treated as follows: get ointment prepared by the embodiment of the present invention 1, get the lymph node being applied in enlargement in right amount, and morning and evening every day is each once, continuous use one week.Matched group infant oral amoxicillin 50mg-100mg/kg/d, every bu 3 times is oral; Ribavirin 10mg/kg/d, every day 1 time is oral, takes medicine altogether one week.Two groups of infants, after treating one week, analyze therapeutic effect by following criterion of therapeutical effect: cure: red and swollen under jaw, pain disappears; Effective: red and swollen, pain relief under jaw; Invalid: symptom is without improvement.
Result of the test is specifically see table 1.From the test data of table 1, test group total effective rate, apparently higher than matched group, is respectively 91.67% and 65.22%.
Table 1 test group and the statistical result of matched group curative effect

Claims (3)

1. treat an externally-applied medicinal composition for pediatric neck acute lymphadenitis, it is characterized in that: be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Lonicerae 23 parts, Spica Prunellae 23 parts, the Radix Angelicae Dahuricae 32 parts, Rhizoma Paridis 20 parts, Radix Glycyrrhizae Preparata 15 parts, Concha Arcae 32 parts, Fructus Arctii 20 parts, Borneolum Syntheticum 8 parts.
2. the externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis according to claim 1, is characterized in that: described externally-applied medicinal composition is ointment, liniment or gel.
3. the application of externally-applied medicinal composition according to claim 1 in the external used medicine of preparation treatment pediatric neck acute lymphadenitis.
CN201410044290.XA 2014-02-01 2014-02-01 A kind of externally-applied medicinal composition for the treatment of pediatric neck acute lymphadenitis Active CN103751490B (en)

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Inventor after: Hu Fang

Inventor after: Zhang Qinmei

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Patentee after: Qidong Jiulong shunzhou toy factory

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Patentee before: Wang Xueyan