Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, and a kind of rheumatism antiinflammation pain-stopping pharmaceutical composition is provided.
For solving the problems of the technologies described above, this rheumatism antiinflammation pain-stopping pharmaceutical composition by following component according to shown in weight ratio scope prepare, 7~17 parts of Rhizoma Et Radix Notopterygiis, 7~17 parts of Radix Angelicae Pubescentiss, 1~11 part, river processed, 1~11 part of Radix Aconiti Kusnezoffii, 4~14 parts of Ramulus Cinnamomi, 7~17 parts of Radix Gentianae Macrophyllae, 7~17 parts of Radix Angelicae Sinensis, 10~20 parts of Rhizoma Chuanxiongs, 1~11 part of the Radix Aucklandiae, 11~21 parts of Olibanums, 5~15 parts of Radix Aconiti Lateralis Preparatas, 1~11 part of Cortex Cinnamomi, 1~11 part, Radix Glycyrrhizae, 5~15 parts of Fructus Liquidambaris.
As optimum ratio scope, described pharmaceutical composition by following component according to shown in weight ratio scope prepare, 11~13 parts of Rhizoma Et Radix Notopterygiis, 11~13 parts of Radix Angelicae Pubescentiss, 5~7 parts, river processed, 5~7 parts of Radix Aconiti Kusnezoffii, 8~10 parts of Ramulus Cinnamomi, 11~13 parts of Radix Gentianae Macrophyllae, 11~13 parts of Radix Angelicae Sinensis, 14~16 parts of Rhizoma Chuanxiongs, 5~7 parts of the Radix Aucklandiae, 15~17 parts of Olibanums, 9~11 parts of Radix Aconiti Lateralis Preparatas, 5~7 parts of Cortex Cinnamomis, 5~7 parts, Radix Glycyrrhizae, 9~11 parts of Fructus Liquidambaris.
As optimum ratio, described pharmaceutical composition by following component according to shown in weight ratio prepare, pharmaceutical composition by following component according to shown in weight ratio scope prepare, 17 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Radix Angelicae Pubescentiss, 11 parts, river processed, 1 part of Radix Aconiti Kusnezoffii, 14 parts of Ramulus Cinnamomi, 7 parts of Radix Gentianae Macrophyllae, 17 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 11 parts of the Radix Aucklandiae, 11 parts of Olibanums, 15 parts of Radix Aconiti Lateralis Preparatas, 1 part of Cortex Cinnamomi, 11 parts, Radix Glycyrrhizae, 5 parts of Fructus Liquidambaris.
As optimum ratio, described pharmaceutical composition by following component according to shown in weight ratio prepare, 7 parts of Rhizoma Et Radix Notopterygiis, 17 parts of Radix Angelicae Pubescentiss, 1 part, river processed, 11 parts of Radix Aconiti Kusnezoffii, 4 parts of Ramulus Cinnamomi, 17 parts of Radix Gentianae Macrophyllae, 7 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiongs, 1 part of the Radix Aucklandiae, 21 parts of Olibanums, 5 parts of Radix Aconiti Lateralis Preparatas, 11 parts of Cortex Cinnamomis, 1 part, Radix Glycyrrhizae, 15 parts of Fructus Liquidambaris.
As further optimum ratio, described pharmaceutical composition by following component according to shown in weight ratio prepare, 13 parts of Rhizoma Et Radix Notopterygiis, 11 parts of Radix Angelicae Pubescentiss, 7 parts, river processed, 5 parts of Radix Aconiti Kusnezoffii, 10 parts of Ramulus Cinnamomi, 11 parts of Radix Gentianae Macrophyllae, 13 parts of Radix Angelicae Sinensis, 14 parts of Rhizoma Chuanxiongs, 7 parts of the Radix Aucklandiae, 15 parts of Olibanums, 11 parts of Radix Aconiti Lateralis Preparatas, 5 parts of Cortex Cinnamomis, 7 parts, Radix Glycyrrhizae, 9 parts of Fructus Liquidambaris.
As further optimum ratio, described pharmaceutical composition by following component according to shown in weight ratio prepare, 11 parts of Rhizoma Et Radix Notopterygiis, 13 parts of Radix Angelicae Pubescentiss, 5 parts, river processed, 7 parts of Radix Aconiti Kusnezoffii, 8 parts of Ramulus Cinnamomi, 13 parts of Radix Gentianae Macrophyllae, 11 parts of Radix Angelicae Sinensis, 16 parts of Rhizoma Chuanxiongs, 5 parts of the Radix Aucklandiae, 17 parts of Olibanums, 9 parts of Radix Aconiti Lateralis Preparatas, 7 parts of Cortex Cinnamomis, 5 parts, Radix Glycyrrhizae, 11 parts of Fructus Liquidambaris.
As best proportioning, described pharmaceutical composition by following component according to shown in weight ratio prepare, 12 parts of Rhizoma Et Radix Notopterygiis, 12 parts of Radix Angelicae Pubescentiss, 6 parts, river processed, 6 parts of Radix Aconiti Kusnezoffii, 9 parts of Ramulus Cinnamomi, 12 parts of Radix Gentianae Macrophyllae, 12 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 6 parts of the Radix Aucklandiae, 16 parts of Olibanums, 10 parts of Radix Aconiti Lateralis Preparatas, 6 parts of Cortex Cinnamomis, 6 parts, Radix Glycyrrhizae, 10 parts of Fructus Liquidambaris.
As optimization formula amount, every pair of formula of described pharmaceutical composition is, Rhizoma Et Radix Notopterygii 12g, Radix Angelicae Pubescentis 12g, river 6g processed, Radix Aconiti Kusnezoffii 6g, Ramulus Cinnamomi 9g, Radix Gentianae Macrophyllae 12g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, Radix Aucklandiae 6g, Olibanum 16g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 6g, Radix Glycyrrhizae 6g, Fructus Liquidambaris 10g.
This rheumatism antiinflammation pain-stopping pharmaceutical composition dosage form is decoction, its preparation method is, by above-mentioned weight ratio or formula, measure each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, mixed-powder, in this mixed-powder with vinegar fried dry, then add decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction.
Pharmacology analysis
Rhizoma Et Radix Notopterygii: bitter in the mouth, is slightly cold.Return Liver Channel.Function cures mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, tepor; Return liver, kidney, urinary bladder channel; Expelling wind and dampness, dispersing cold for relieving pain, for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, headache toothache.
River processed: acrid in the mouth, hardship, hot in nature; GUIXIN, liver,kidney,spleen warp; Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, mastalgia, chest pain with distension sensation, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Aconiti Kusnezoffii: acrid in the mouth, warm in nature; GUIXIN, liver,kidney,spleen warp; Search wind prevailing over dampness, dispersing cold for relieving pain, opens expectorant, and detumescence, controls anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature; Return bladder, the heart, lung meridian; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI in the collateral by warming the meridian.
Radix Gentianae Macrophyllae: acrid in the mouth, hardship, cold nature; Return stomach, liver, gallbladder meridian; Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat, clearing away damp-heat, for rheumatic arthralgia, apoplectic dyscinesia, the contracture of muscle arteries and veins, joint ache, the heating of afternoon fever, infantile malnutrition, jaundice due to damp-heat.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent, returns liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For diseases such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down and ulcer sores.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, heart channel; There is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature; Return spleen, large intestine, tri-jiao channel; Circulation of qi promoting, pain relieving, spleen invigorating, help digestion, promoting the circulation of QI to relieve pain, adjust in intestinal stasis relieving.
Olibanum: acrid in the mouth, hardship, warm in nature; GUIXIN, liver, spleen channel; Regulating qi and activating blood, fixed logical, chase after malicious effect.Myrrha: bitter in the mouth, pungent, property is flat; Return liver, spleen, the heart, kidney channel; Logical stagnant blood, beats and flutters damage pain, promoting blood circulation and stopping pain, detumescence and promoting granulation.
Radix Aconiti Lateralis Preparata: acrid in the mouth, sweet, hot in nature; GUIXIN, kidney, spleen channel; Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain, and for YANG-depletion collapse, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness is vomited and diarrhoea, coldness and pain in the epigastrium, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Cortex Cinnamomi: acrid in the mouth, sweet, hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, warming the spleen and stomach, removing accumulated cold, promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Radix Glycyrrhizae: sweet in the mouth, property is flat; Return spleen, stomach, lung meridian; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Liquidambaris: bitter in the mouth, property is flat; Return liver, kidney channel; Dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
It is monarch drug that a kind of rheumatism antiinflammation pain-stopping pharmaceutical composition of the present invention be take Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, river processed, Radix Aconiti Kusnezoffii, and take Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Aucklandiae, Olibanum is ministerial drug, take Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Radix Glycyrrhizae, Fructus Liquidambaris as adjuvant formulated; In side all medicine compatibilities, the monarch and his subjects pull together, help make auxiliary altogether, make this medical instrument have the effect of quick reducing swelling and alleviating pain, first separate its table, and take expelling wind and removing dampness as object, can progressively improve human body resistance against diseases, physical strength reinforcing, increases bone density, increase the effect of immunity, finally reached treating both the principal and secondary aspects of a disease, the elimination persistent ailment of working along both lines.
The specific embodiment
Embodiment 1: the formula by Rhizoma Et Radix Notopterygii 17g, Radix Angelicae Pubescentis 7g, river 11g processed, Radix Aconiti Kusnezoffii 1g, Ramulus Cinnamomi 14g, Radix Gentianae Macrophyllae 7g, Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 10g, Radix Aucklandiae 11g, Olibanum 11g, Radix Aconiti Lateralis Preparata 15g, Cortex Cinnamomi 1g, Radix Glycyrrhizae 11g, Fructus Liquidambaris 5g measures each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, obtain mixed-powder, to in this mixed-powder with vinegar fried dry, add again decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction A.
Embodiment 2: the formula by Rhizoma Et Radix Notopterygii 7g, Radix Angelicae Pubescentis 17g, river 1g processed, Radix Aconiti Kusnezoffii 11g, Ramulus Cinnamomi 4g, Radix Gentianae Macrophyllae 17g, Radix Angelicae Sinensis 7g, Rhizoma Chuanxiong 20g, Radix Aucklandiae 1g, Olibanum 21g, Radix Aconiti Lateralis Preparata 5g, Cortex Cinnamomi 11g, Radix Glycyrrhizae 1g, Fructus Liquidambaris 15g measures each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, obtain mixed-powder, to in this mixed-powder with vinegar fried dry, add again decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction B.
Embodiment 3: the formula by Rhizoma Et Radix Notopterygii 13g, Radix Angelicae Pubescentis 11g, river 7g processed, Radix Aconiti Kusnezoffii 5g, Ramulus Cinnamomi 10g, Radix Gentianae Macrophyllae 11g, Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 14g, Radix Aucklandiae 7g, Olibanum 15g, Radix Aconiti Lateralis Preparata 11g, Cortex Cinnamomi 5g, Radix Glycyrrhizae 7g, Fructus Liquidambaris 9g measures each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, obtain mixed-powder, to in this mixed-powder with vinegar fried dry, add again decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction C.
Embodiment 4: the formula by Rhizoma Et Radix Notopterygii 11g, Radix Angelicae Pubescentis 13g, river 5g processed, Radix Aconiti Kusnezoffii 7g, Ramulus Cinnamomi 8g, Radix Gentianae Macrophyllae 13g, Radix Angelicae Sinensis 11g, Rhizoma Chuanxiong 16g, Radix Aucklandiae 5g, Olibanum 17g, Radix Aconiti Lateralis Preparata 9g, Cortex Cinnamomi 7g, Radix Glycyrrhizae 5g, Fructus Liquidambaris 11g measures each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, obtain mixed-powder, to in this mixed-powder with vinegar fried dry, add again decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction D.
Embodiment 5: the formula by Rhizoma Et Radix Notopterygii 12g, Radix Angelicae Pubescentis 12g, river 6g processed, Radix Aconiti Kusnezoffii 6g, Ramulus Cinnamomi 9g, Radix Gentianae Macrophyllae 12g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, Radix Aucklandiae 6g, Olibanum 16g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 6g, Radix Glycyrrhizae 6g, Fructus Liquidambaris 10g measures each component, each component is pulverized and ground rear 100~200 mesh sieves of crossing, obtain mixed-powder, to in this mixed-powder with vinegar fried dry, add again decocting system 3~5h, the filtration soup of getting it filled, obtains this rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E.
Wherein, the rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E clinical application effect of embodiment 5 preparations is best, therefore be embodiment 5 most preferred embodiments.
Clinical data
600 routine patients are treated to observation, to prove that medicine of the present invention has original curative effect to the patient of all kinds of rheumatic and rheumatoid pain,
All cases patient clinical is observed and is had no any untoward reaction.
In sum, a kind of rheumatism antiinflammation pain-stopping pharmaceutical composition of the present invention is effective and safe drugs.
Model case:
Case 1: Jiang, man, 70 years old, first visit whole body arthralgia in 2009, tossed about in bed the treatment of Beijing, Shanghai and recovers half a year and to increase the weight of, and extremities joint is tetanic, can not walk for a long time, loses work capacity.X-ray film shows that bilateral sacroiliac joint destroys, and hip joint space obviously narrows down, and is diagnosed as rheumatoid arthritis stubborn, take the rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E treatment of month that the present embodiment 5 makes, arthralgia fades, functional rehabilitation, takes care of oneself, follow-up investigation, drug withdrawal has no recurrence for 2 years.
Case 2: Lin, female, 63 years old, teacher, suffer from rheumatoid arthritis 5 years, Long-term Hormone medicine and analgesic, the state of an illness day by day increases the weight of, and there is whole body and puffiness of face, whole body arthralgia, both hands deformity of joint, duplex, knee joint is tetanic, and reason is lost in life completely, take the rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E six months that the present embodiment 5 makes, arthralgia disappears substantially, and function is improved, can be engaged in normal work, after drug withdrawal, follow up a case by regular visits to, so far not recurrence.
Case 3: Feng, man, 65 years old, peasant, because there is the gonalgia in wound, redness and swelling of joints, through hospital chemical examination, be diagnosed as rheumatoid arthritis, informal dress for, the curative effect of medication such as indometacin, prednisone is not good enough, takes mono-month pair of lower limb of rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E that the present embodiment 5 makes by cold alternating temperature, spirit is good, follows up a case by regular visits to existing can going to work in the fields.
Case 4: Hu, female, 42 years old, workman is trouble rheumatic and rheumatoid arthritis, limb arthralgia through hospital diagnosis, stiff, two fingers deformed, cannot close up, finger cannot normally be worked, and takes the rheumatism antiinflammation pain-stopping pharmaceutical composition decoction E that the present embodiment 5 makes, through bimestrial treatment, symptom obviously alleviates, and finger can close up completely as normal person, and can work, tracking is followed up a case by regular visits to, without recurrence.
Above-mentioned embodiment is intended to illustrate the present invention and can be professional and technical personnel in the field's realization or use; it will be apparent for those skilled in the art that above-mentioned embodiment is modified; therefore the present invention includes but be not limited to above-mentioned embodiment; any these claims or description of meeting described; meet and principle disclosed herein and novelty, the method for inventive features, technique, product, within all falling into protection scope of the present invention.