CN103736165A - 流体分配器件、流体流的测量方法和系统及流体输送系统 - Google Patents

流体分配器件、流体流的测量方法和系统及流体输送系统 Download PDF

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Publication number
CN103736165A
CN103736165A CN201410003253.4A CN201410003253A CN103736165A CN 103736165 A CN103736165 A CN 103736165A CN 201410003253 A CN201410003253 A CN 201410003253A CN 103736165 A CN103736165 A CN 103736165A
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fluid
pump
volume
pumping
valve
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CN103736165B (zh
Inventor
迪安·卡门
拉塞尔·H·比维斯
德里克·G·卡纳
约翰·M·克尔温
拉里·B·格雷
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Deka Products LP
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Deka Products LP
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Priority claimed from CN200780007307.2A external-priority patent/CN101400391B/zh
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Abstract

本发明公开了流体分配器件、流体流的测量方法和系统及流体输送系统。用于分配流体的器件包括:贴片大小的壳体,所述壳体封装与下游阻流弯曲导管串联的加压流体源。用于测量通过管线输送的流体流的方法包括:在由联接到声学邻接区域的子区域空间的区域中的流体流引起的该子区域的容积变化期间,仅仅在单一频率下以声学方式激发所述声学邻接区域中的气体,以产生声学响应;确定在所述声学邻接区域中的第一位置处测量的声学响应和用于所述单一频率的基准之间的相位关系;基于所述相位关系的时间演变,计算所述子区域的容积变化;并且基于所述子区域中的气体的体积变化,推断通过所述管线的流体流的测量结果。

Description

流体分配器件、流体流的测量方法和系统及流体输送系统
分案申请 
本申请是2007年2月9日提交的申请号为200780007307.2、发明名称为“流体输送系统和方法”的中国专利申请的分案申请。 
技术领域
本申请总体涉及一种流体输送系统和方法。 
背景技术
由于吸收不良、肝脏代谢或者其它药物动力学因素,很多有潜在价值的包括生物制品的药物或者化合物不是口服有效的。另外,一些治疗化合物,虽然它们能够经过口服吸收,但有时要求经常地给药,以致患者难以保持预期计划。在这些情形中,经常采用或者能够采用肠胃外输送。 
药品输送以及其它流体和化合物的输送的有效肠胃外路径,例如皮下注射、肌肉注射、和静脉内(IV)给药,包括利用针或者口针刺透皮肤。胰岛素是数以千万的糖尿病患者自行注射的治疗流体的一个实例。肠胃外输送药品的用户将受益于一种能够在一段时期期间自动输送所需药品/化合物的可配戴器件。 
为此,已经对用于治疗物受控释放的便携式器件设计做出努力。已知这种器件具有储液器,例如药筒、注射器或者药袋,并且以电子方式受控。这些器件不利地具有多个缺点,包括故障率。减小这些器件的尺寸、重量和成本也是目前存在的难题。 
发明内容
根据本发明的第一个方面,提供了一种用于分配流体的器件,所述器件包括:贴片大小的壳体,所述壳体封装与下游阻流弯曲导管串联的加压流体源。 
根据本发明的第二个方面,提供了一种用于分配流体的器件,所述器件包括:贴片大小的壳体;置于所述壳体中的泵,所述泵具有泵出口;同样置于所述壳体中的分配腔室,所述分配腔室具有分配进口和分配出口,其中所述分配进口联接到所述泵出口;以及联接到所述分配出口以提供流阻的弯曲导管。 
根据本发明的第三个方面,提供了一种用于测量通过管线输送的流体流的方法,该方法包括:在由联接到声学邻接区域的子区域空间的区域中的流体流引起的该子区域的容积变化期间,仅仅在单一频率下以声学方式激发所述声学邻接区域中的气体,以产生声学响应;确定在所述声学邻接区域中的第一位置处测量的声学响应和用于所述单一频率的基准之间的相位关系;基于所述相位关系的时间演变,计算所述子区域的容积变化;并且基于所述子区域中的气体的体积变化,推断通过所述管线的流体流的测量结果。 
根据本发明的第四个方面,提供了一种用于测量通过管线输送的流体流的系统,所述系统包括:声学能量源,所述声学能量源用于在由联接到声学邻接区域的子区域空间的区域中的流体流而引起的该子区域的容积变化期间,仅仅在单一频率下以声学方式激发所述声学邻接区域中的气体以产生声学响应;第一声转换器,其安装在所述声学邻接区域中的第一位置处,以基于所述声学响应产生电信号,所述第一声转换器的电信号关于基准具有相位关系;以及处理器,所述处理器联接到所述第一声转换器和所述基准,执行流动确定过程,以基于所述相位关系的时间演变而确定与所述子区域的容积变化有关的量;并且基于所述子区域中的气体的体积变化推断通过所述管线的流体流的测量结果。 
根据本发明的第五个方面,提供了一种流体输送系统,其利用上述用于测量通过管线输送的流体流的系统,所述流体输送系统造成通过所述管线输送的流体流,并且还包括:联接到处理器的泵;其中所述处理器的功耗并不显著大于所述泵的功耗。 
在一个实施例中,本发明提供一种分配流体的方法。在该实施例中,该方法包括三个过程。这些过程的第一个过程包括将流体泵送到弹性的可变容积分配腔室中。所述分配腔室与常规存在的有限流阻和出口串联。即使一些流体流过所述出口,所述流阻也足以使得所述分配腔室在所述分配腔室接收被泵送的流体时膨胀。这些过程中的另一个过程包括随着时间而重复地测量与分配腔室容积有关的参数。这些过程的第三个过程包括基于所述参数的重复测量结果控制流体泵送,以产生通过所述出口部的所需流体流。 
在相关实施例中,重复测量参数包括以声学方式激发声学邻接区域中的气体,以在其中产生声学响应。所述区域包括子区域,所述子区域被联接到所述分配腔室,从而所述分配腔室的容积变化引起所述子区域的容积变化。该实施例还包括对声学响应进行表征。 
在另一相关实施例中,以声学方式激发气体仅仅在单一频率下进行。而且,表征所述声学响应包括确定在声学邻接区域中的第一位置处测量的声学响应和用于所述单一频率的基准之间的相位关系。该实施例的方法还包括基于所述相位关系的时间演变来计算所述子区域的容积变化。 
可替代地或者另外地,所述阻抗是无源阻抗。所述无源阻抗可以可选地包括导管。所述导管可以具有多种形式中的任何一种。它可以包括盘管。所述盘管可以包括至少两个弯头。可替代地或者另外地,所述导管具有蛇形形状。 
而且,可替代地或者另外地,基于流体粘度和密度的至少一个而选择所述导管的长度和内径,以提供预定阻抗。可选地,所述内径足够大,从而防止由于治疗液体流过导管而造成的堵塞。可选地,所述导管具有大于2cm的长度。 
在又一个实施例中,所述方法包括,提供能够连接到上游流体源的进口管线。所述进口管线在下游与泵送腔室流体连通。所述泵送腔室具有泵出口。所述方法还包括致动作用力施加组件,从而当加压泵送腔室以迫使通过泵出口流动时限制流体通过所述进口倒流。 
在相关实施例中,致动所述作用力施加组件的过程包括在工作冲程期间利用所述作用力施加组件的行进,以在一个机械动作中限制倒流并且加压所述泵送腔室。在另一相关实施例中,所述作用力致动组件的给定程度的行进限制了倒流,并且更高程度的行进加压所述泵送腔室。 
在另一相关实施例中,致动所述作用力施加组件的过程包括通过堵塞进口管线而限制朝向所述流体源的倒流。可替代地或者另外地,所述方法还包括通过使用置于分配腔室和泵送腔室之间的无源阀门而防止流体从分配腔室反向流动到泵送腔室中。 
在另一相关实施例中,例如,通过提供从所述泵输出返回所述流体源的分流线,可以允许被泵送的流体的一部分返回流体源(例如,非加压流体储液器)而非进入所述分配腔室。 
在另一相关实施例中,利用位于贴片大小的壳体内部的构件执行前述的三个过程。所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。 
可选地,所述导管包括基于流体粘度和密度的至少一个选择以提供预定阻抗的长度。还可选地,所述分配腔室具有进口,并且所述导管的内径小于所述分配腔室进口的内径。 
在另一实施例中,本发明提供一种用于分配流体的器件。在该实施例中,所述器件包括贴片大小的壳体;在所述壳体中封装的泵;以及位于所述泵的下游并且与其流体连通的分配组件。所述分配组件具有弹性分配腔室和传感器,所述传感器用于定量地测量与分配腔室容积或者所述容积关于时间的导数有关的参数。所述泵以脉动方式喷射流体从而循环地使所述弹性分配腔室膨胀,并且所述腔室通过出口重复地输送流体。所述器件还包括控制环,所述控制环联接到所述传感器和所述泵,用于基于所测量参数在正常流动状态期间控制所述泵的致动,从而实现具有所期望累积体积的流体输送。所述环包括控制器,所述控制器基于所测量参数确定通过所述出口输送的流体的累积体积。 
另一相关实施例还包括声学能量源,其用于以声学方式激发声学邻接区域中的气体,以在其中产生声学响应。所述区域包括子区域,所述子区域连接到所述分配腔室,从而所述分配腔室的容积改变引起所述子区域的容积改变。另外,所述实施例包括处理器,并且所述传感器包括第一声转换器,其安装在声学邻接区域中的第一位置处,用于基于所述声学响应产生电信号。所述处理器联接于所述第一声转换器和基准,并且执行流动确定过程,用于基于所述声学响应确定与所述子区域容积变化有关的量。 
可选地,所述声学能量源仅仅在单一频率下激发气体,并且由所述第一声转换器产生的电信号关于所述基准具有一定相位关系;并且所述流动确定过程基于所述相位关系的时间演变确定与所述子区域容积变化有关的量。 
另外,可选地,该实施例的器件还包括联接于所述出口的有限流体阻抗。所述阻抗足以允许所述弹性分配腔室发生这种膨胀。而且,可选地,所述阻抗是无源阻抗。所述无源阻抗可以可选地包括导管。如在上述方法的情形中,所述导管可以具有多种形式中的任何一种。它可以包括盘管。所述盘管可以包括至少两个弯头。可替代地或者另外地,所述导管具有蛇形形状。 
而且,可替代地或者另外地,所述导管具有为基于流体粘度和密度的至少一个提供预定阻抗而选择的一定长度和内径。可选地,所述内径足够大从而防止由于治疗液体流过所述导管而造成的堵塞。可选地,所述导管具有大于2cm的长度。 
在另一相关实施例中,所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。可选地,所述分配腔室具有进口,并且所述导管的内径小于所述分配腔室进口的内径。 
可选地,本发明提供一种用于泵送流体通过流动管线的系统。在该实施例中,所述系统包括泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,以及泵出口。所述系统还包括适于向所述泵送腔室提供压缩冲程的作用力施加组件。在该实施例中,当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程使得可以限制流体通过所述进口而从泵送腔室倒流。 
可选地,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体被从所述泵送腔室促动到所述泵出口时,所述压缩冲程致动所述进口和所述流体源之间联接的进口阀门以关闭所述阀门。 
可选地,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器 的协同操作。可选地,所述马达包括形状记忆致动器。还可选地,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。可选地,所述作用力施加组件包括马达。 
另外地,或者可替代地,可以提供分流线,该分流线与所述泵的输出和流体源(例如,非加压流体储液器)流体连通以允许被所述泵喷射的流体的一部分返回到所述流体源。 
在另一实施例中,本发明提供一种用于分配流体的器件,并且所述器件包括贴片大小的壳体。所述壳体封装了与下游阻流弯曲导管串联的加压流体源。 
在另一相关实施例中,所述器件还包括用于测量与流到所述导管的流体流有关的参数的传感器以及用于基于所测量参数调节所述流体流的控制环。 
可选地,所述流体源包括以可操作方式联接以向下游阻流弯曲导管提供加压流体的泵。还可选地,所述器件包括传感器,用于测量与流到所述导管的流体流有关的参数的传感器以及用于基于所测量参数调节所述泵的操作的控制环。 
可选地,本发明提供一种用于泵送流体通过流动管线的系统。在该实施例中,所述系统包括泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,以及泵出口。所述系统还包括适于向所述泵送腔室提供压缩冲程的作用力施加组件。在该实施例中,当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程使得可以限制流体通过所述进口从泵送腔室倒流。 
可选地,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体被从所述泵送腔室促动到所述泵出口 时,所述压缩冲程致动所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。 
可选地,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器的协同操作。可选地,所述马达包括形状记忆致动器。还可选地,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。可选地,所述作用力施加组件包括马达。 
另外地,或者可替代地,可以提供分流线,该分流线与所述泵的输出和流体源(例如,非加压流体储液器)流体连通,以允许被所述泵喷射的流体的一部分返回到所述流体源。 
在另一相关实施例中,所述流体源还包括以可操作方式联接以向所述泵提供流体的非加压储液器。 
如在前面的实施例中那样,所述阻流弯曲导管可以以各种方式实现。它例如可以是盘绕的。它可以包括至少两个弯头。可替代地或者另外地,所述阻流弯曲导管具有蛇形形状。可选地,所述壳体包括具有包括所述阻流弯曲导管的一体流体路径的一次性部分。还可选地,所述导管被置于所述壳体中。可选地,所述导管具有为基于流体粘度和密度的至少一个提供预定阻抗而选择的一定长度和内径。可选地,所述内径足够大,从而防止由于治疗液体流过所述导管而造成的堵塞。可选地,所述导管具有大于2cm的长度。可选地,所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。 
在另一相关实施例中,所述器件另外地包括与所述流体源和所述导管流体连通的分配腔室。所述分配腔室包括进口和出口,通过该进口而从所述流体源接收流体,通过该出口向所述导管提供流体。可选地,所述导管的内径小于所述分配腔室进口的内径。 
可替代地或者另外地,所述分配腔室是弹性的可变容积分配腔室。可选地,所述导管具有小于所述进口的有效直径的有效直径。 
可选地,本发明提供一种用于泵送流体通过流动管线的系统。在该实施例中,所述系统包括泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,以及泵出口。所述系统还包括适于向所述泵送腔室提供压缩冲程的作用力施加组件。在该实施例中,当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程使得可以限制流体通过所述进口从泵送腔室倒流。 
可选地,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体被从所述泵送腔室促动到所述泵出口时,所述压缩冲程致动所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。 
可选地,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器,以及马达,用于所述阀门致动器和所述泵致动器的协同操作。可选地,所述马达包括形状记忆致动器。还可选地,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。可选地,所述作用力施加组件包括马达。 
另外地,或者可替代地,可以提供分流线,该分流线与所述泵出口和流体源(例如,非加压流体储液器)流体连通,以允许被所述泵喷射的流体的一部分返回到所述流体源。 
在另一实施例中,本发明提供一种用于分配流体的器件。所述器件包括贴片大小的壳体和置于所述壳体中的泵。所述泵具有泵出口。所述器件还包括也被置于所述壳体中的分配腔室。所述分配腔室具有分配进口和分配出口。所述分配进口联接到所述泵出口。所述器件还 包括联接到所述分配出口以提供阻流的弯曲导管。 
可选地,所述器件包括用于测量与流到所述导管的流体流动有关的参数的传感器;以及用于基于所测量参数调节所述调节所述泵的操作的控制环。还可选地,所述器件还包括置于所述壳体中并且以可操作方式联接以向所述泵的进口提供流体的非加压储液器。 
如在前面的实施例中那样,所述弯曲导管可以以各种方式实现。它例如可以是盘绕的。它可以包括至少两个弯头。可替代地或者另外地,所述弯曲导管具有蛇形形状。可选地,所述导管被置于所述壳体中。可选地,所述壳体具有包括所述弯曲导管的一体流体路径的一次性部分。可选地,所述导管具有大于2cm的长度。可选地,所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。可选地,所述导管具有基于流体粘度和密度的至少一个提供预定阻抗而选择的一定内径。可选地,所述导管具有为基于流体粘度和密度的至少一个提供预定阻抗而选择的一定长度和内径。可选地,所述内径足够大,从而防止由于治疗液体流过所述导管而造成的堵塞。 
可选地,所述分配腔室是弹性可变容积分配腔室。还可选地,所述分配腔室具有进口,并且所述导管的内径小于所述分配腔室进口的内径。 
在另一实施例中,本发明提供一种用于测量通过管线输送的流体流的方法。该实施例的方法包括,在由于连接到声学邻接区域的子区域空间的区域中的流体流而引起的子区域容积发生变化期间,仅仅在单一频率下以声学方式激发声学邻接区域中的气体,以产生声学响应。另外,所述方法包括,确定在于声学邻接区域中的第一位置处测量的声学响应和用于所述单一频率的基准之间的相位关系;基于所述相位关系的时间演变计算所述子区域的容积变化;并且基于所述子区域中的气体体积变化推断通过所述管线的流体流测量结果。 
可选地,所述方法还包括在声学邻接区域中的第二位置处测量所述基准。还可选地,所述区域经由隔膜连接到所述子区域的空间。 
在另一相关实施例中,以声学方式激发气体的步骤包括驱动转换器。可选地,以声学方式激发气体的过程包括驱动扬声器。所述实施例可选地包括作为所述子区域容积的函数校准所述相位关系。可选地,所述声学邻接区域具有小于200微升的容积。在又一个实施例中,所述声学邻接区域具有小于130微升的容积。在又一个实施例中,所述声学邻接区域具有小于10微升的容积。 
可选地,计算所述容积变化的过程包括以优于20纳升的分辨率确定这种变化。在又一个实施例中,计算所述容积变化的过程包括以优于15纳升的分辨率确定这种变化。在又一个实施例中,计算所述容积变化的过程包括以优于13纳升的分辨率确定这种变化。在另外一个实施例中,计算所述容积变化的过程包括以声学邻接区域容积的至少万分之一的分辨率确定这种变化。 
可选地,所述单一频率是或者接近所述子区域的共振频率。 
在另一相关实施例中,所述方法还包括通过在一连串频率下以声学方式激发所述区域并且确定传递函数而运行校准阶段,该传递函数表征了声学邻接区域中的第一位置处测量的声学响应和用于所述一连串频率的每一个频率的基准之间的作为频率函数的相位关系。 
可选地,所述方法还包括在声学邻接区域中的第二位置处测量用于所述一连串频率的每一个频率的基准。可替代地或者另外地,所述方法还包括基于所述传递函数探测气泡存在性。可选地,所述方法还包括当探测到气泡存在时进入警报状态。可选地,所述容积变化的计算在测量阶段期间重复执行并且与校准阶段交替地执行测量阶段。在 另一相关实施例中,循环地输送流体,并且所述校准和测量阶段与所述循环相协作。 
在另一实施例中,本发明提供一种用于测量通过管线输送的流体流的系统。在该实施例中,所述系统包括声学能量源,所述声学能量源用于在由于连接到声学邻接区域的子区域空间的区域中的流体流而引起子区域容积发生变化期间,仅仅在单一频率下以声学方式激发声学邻接区域中的气体,以产生声学响应。所述系统还包括第一声转换器,该第一声转换器安装在声学邻接区域中的第一位置处,基于所述声学响应产生电信号。所述第一声转换器的电信号具有与基准有关的相位关系。所述系统还包括处理器,所述处理器联接到所述第一声转换器和所述基准,执行流动确定过程,以便基于所述相位关系的时间演变确定与所述子区域的容积变化有关的量;并且基于所述子区域中的气体的体积变化推断通过所述管线的流体流测量结果。 
可选地,所述系统还包括第二声转换器,该第二声转换器安装在所述声学邻接区域中的第二位置处,用于产生构成所述基准的电信号。还可选地,所述系统具有小于每日500焦耳的功耗。 
在另一相关实施例中,提供一种利用根据前述实施例的用于测量通过流动管线输送的流体流的系统的流体输送系统。该实施例的流体输送系统使得通过所述流动管线而输送的流体进行流动,并且另外地包括联接到所述处理器的泵。 
可选地,本发明提供一种用于泵送流体通过流动管线的系统。在该实施例中,所述系统包括泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,以及泵出口。所述系统还包括适于向所述泵送腔室提供压缩冲程的作用力施加组件。在该实施例中,当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程使得可以限制流体通过所述进口从泵送腔室倒流。 
可选地,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体被从所述泵送腔室促动到所述泵出口时,所述压缩冲程致动所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。 
可选地,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器的协同操作。可选地,所述马达包括形状记忆致动器。还可选地,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。可选地,所述作用力施加组件包括马达。 
所述处理器的功耗并不显著大于所述泵的功耗。可选地,所述系统还包括将所述区域连接到所述子区域空间的隔膜。还可选地,所述声学能量源包括耦合到电信号的声转换器。可选地,所述转换器是扬声器。 
在另一相关实施例中,所述处理器执行用于作为所述子区域容积的函数而校准所述相位关系的校准过程。可选地,所述声学邻接区域具有小于200微升的容积。在又一个实施例中,所述声学邻接区域具有小于130微升的容积。在又一个实施例中,所述声学邻接区域具有小于10微升的容积。 
可替代地或者另外地,所述流动确定过程相应于优于20纳升的分辨率而确定与容积变化有关的量。在又一个实施例中,所述流动确定过程相应于优于15纳升的分辨率而确定与容积变化有关的量。在又一个实施例中,所述流动确定过程相应于优于13纳升的分辨率而确定与容积变化有关的量。在又一个实施例中,所述流动确定过程相应于声学邻接区域容积的至少万分之一的分辨率而确定与容积变化有关的量。 
可选地,所述的单一频率是或者接近所述子区域的共振频率。在又一个实施例中,所述声源包括联接到所述处理器的声音发射转换器。另外,所述处理器实施校准过程,在该过程中它使得声源以声学方式在一连串频率下激发所述区域;并且,作为这种过程的一个部分,所述处理器确定传递函数,该传递函数表征所述第一转换器的电信号和用于所述一连串频率的每一个频率的基准之间的作为频率函数的相位关系。 
在又一个实施例中,所述处理器执行用于基于所述传递函数探测气泡存在性的气泡探测过程。可选地,当探测到气泡存在时,所述气泡探测过程使得所述系统进入警报状态。 
在又一个实施例中,所述流动确定过程在测量阶段期间重复地执行并且所述测量阶段与所述校准阶段交替地执行。可选地,循环地输送流体,并且所述校准和测量阶段与所述循环相协作。 
本发明的这些方面并非旨在是排他性的并且当与所附权利要求和附图相结合进行阅读时本领域普通技术人员易于理解本发明的其它特征、方面和优点。 
附图说明
参考附图通过参考下面的详细说明,将更加易于理解本发明的前述特征,其中: 
图1描绘具有贴片和无线手持用户接口组件的患者; 
图2A是具有反馈控制的流体输送器件的概略图; 
图2B是具有反馈控制和储液器的流体输送器件的概略图; 
图3是具有非加压储液器的流体输送器件的概略图; 
图4A-4C是限流器的各种实施例的概略截面图; 
图5示出与限流器串联的弹性分配组件; 
图6示出具有计量腔室和传感器的分配组件; 
图7示出具有带分配弹簧的计量腔室和传感器的分配组件; 
图8示出具有可替代声学路径的分配组件的截面视图; 
图9示出分配组件的概略视图; 
图10示出用于弹性可变容积分配腔室的膜片弹簧; 
图11A示出示例性基础流体输送的动力学分布; 
图11B示出示例性丸剂流体输送的动力学分布; 
图11C示出代表正常流体输送的动力学数据; 
图11D-11F示出代表各种故障状态的动力学数据; 
图12示出流体输送器件实施例的感测和反应过程的流程图; 
图13示出具有压力产生组件的流动管线的框图; 
图14示出具有阀门泵的流动管线的框图; 
图15A-15D示出泵送机构的概略图; 
图16示出泵送机构的概略图; 
图17概略示出能够具有多个泵送模式的包括形状记忆致动器的实施例的截面视图; 
图18概略示出包括两个形状记忆致动器并且能够具有多个泵送模式的实施例的截面视图; 
图19概略示出包括不同长度的形状记忆致动器的实施例的截面视图; 
图20A-20B概略示出用于接附形状记忆致动器的实施例; 
图21A-21B概略示出用于将形状记忆致动器接附到泵送机构的实施例; 
图22和23示出采用指状件的泵送机构; 
图24示出采用旋转凸起的泵送机构; 
图25示出采用柱塞和柱塞筒的泵送机构; 
图26示出处于膨胀状态的形状记忆致动器的视图; 
图27示出处于收缩状态的形状记忆致动器的视图; 
图28示出采用柱塞和柱塞筒的泵送组件以及具有杠杆的形状记忆马达的视图; 
图29示出采用柱塞和柱塞筒的泵送组件以及形状记忆马达的视图; 
图30示出采用柱塞和柱塞筒的泵送器件以及在柱塞轴中具有导线的形状记忆马达的视图; 
图31示出具有组合泵和储液器的流动管线实施例; 
图32概略示出处于停歇位置的阀门泵的截面视图; 
图33概略示出处于中间位置的图32的阀门泵的截面视图; 
图34概略示出处于致动位置的图32的阀门泵的截面视图; 
图35概略示出用于阀门泵的泵送膜片的截面视图; 
图36示出用于泵送膜片的膜片弹簧的透视图; 
图37概略示出采用杠杆的阀门泵和形状记忆线致动器的截面视图; 
图38概略示出包括采用弹性柱形屈曲的阀门泵的实施例的截面视图; 
图39概略示出包括具有弹性部件和刚性支撑件的阀门泵屈曲的实施例的截面视图; 
图40概略示出在柔性隔膜上游具有膜片弹簧的处于停歇状态中的阀门泵的截面视图; 
图41概略示出处于中间状态的图40的阀门泵的截面视图; 
图42概略示出处于致动状态的图40的阀门泵的截面视图; 
图43概略示出在柔性隔膜上游具有膜片弹簧的阀门泵的截面视图,其中柔性隔膜周向地接附到作用力施加部件; 
图44概略示出在柔性隔膜上游具有膜片弹簧的阀门泵的截面视图,它包括用于传递作用力的刚性球; 
图45概略示出包括具有弹性泵叶片的阀门泵的实施例的截面视图; 
图46概略示出包括用于阀门泵的可替代形式的弹性泵叶片的实施例的截面视图; 
图47概略示出包括具有多个作用力施加部件的阀门泵的实施例的截面视图; 
图48概略示出处于停歇或者填充模式的包括直角杠杆驱动阀门泵和偏流阀的泵送机构; 
图49概略示出处于致动状态的图48的泵送机构。 
图50概略示出根据本发明实施例具有升高的阀座并且处于关闭位置的偏流阀的截面视图; 
图51概略示出处于打开位置的图50的偏流阀的截面视图; 
图52概略示出根据本发明实施例不具有升高的阀座并且处于打开位置的偏流阀的截面视图; 
图53概略示出处于关闭位置的图52的偏流阀的截面视图;' 
图54概略示出根据本发明实施例作用于阀门出口附近的提升阀上的作用力; 
图55以详细视图概略示出根据本发明实施例作用于阀门进口附近的提升阀上的作用力; 
图56概略示出根据本发明实施例具有可调节开启压力的偏流阀; 
图57和58示出利用非加压储液器的流动管线的概略图; 
图59A-59E示出在流体输送器件中的流体流动的概略图; 
图60A-60D示出在流体输送器件中的流体流动的分解概略图; 
图61A-61C示出在流体输送器件中的流体流动的概略图; 
图62A和62B示出独立器件的概略图; 
图63A-63C示出器件实施例的截面概略图; 
图64A-64D示出器件实施例的截面概略图; 
图65A-65B示出连接到流动管线的输液器件的实施例的截面概略图; 
图66A-66D示出将储液器插入器件中的序列的截面概略图; 
图67A-67F示出流体输送器件的实施例的概略图; 
图68是连接到患者的器件的便携式泵实施例的一个实施例的概略图; 
图69A-69B示出器件的壳体下侧的概略视图; 
图70-70D是描绘在流体输送器件实施例中可用的各种构件的视图; 
图71概略示出可以被组装以形成根据器件实施例的流体输送器件的构件; 
图72示出具有声学体积测量构件的流体输送器件的侧视图; 
图73示出用于声学体积测量的印刷电路板; 
图74示出器件实施例的图示视图; 
图75示出流体输送器件的实施例的图示截面视图; 
图76示出流体输送器件的实施例的分解图示视图; 
图77示出可以被组装以形成流体输送器件的一个实施例的构件的分解视图; 
图78示出流体输送器件的实施例的分解视图; 
图79示出流体输送器件的一个实施例的基部的顶视图; 
图80示出流体输送器件的一个实施例的顶部的下侧; 
图81A-81C示出用于表示在顶部和基部之间夹住储液器20的过程的序列; 
图82示出器件的分解顶视图; 
图83示出器件的一个实施例的底部的分解视图,其中示出流体路径组件、底部壳体和隔膜以及粘结剂; 
图84示出基部的底视图,其中示出流体路径组件的底视图; 
图85A-85D示出器件实施例的分解、局部分解以及非分解视图; 
图86A示出具有输液器件以及所连接的分析物传感器的输液和传感器组件的概略图; 
图86B示出具有引入针的如图86A所示的输液和传感器组件的分解视图; 
图87A-87E示出输液和传感器组件的实施例被插入器件中的序列; 
图88A-88B示出在输液和传感器组件的序列中的插入器器件的一个实施例; 
图88C-88D示出图88A-88B的插入器的局部剖视图; 
图89A示出用于插入输液和传感器组件的插入器器件的一个实施例的前视图; 
图89B示出图89A的插入器件的后视图; 
图90示出用于输液和传感器组件的药筒的一个实施例的透视图; 
图91A-91C示出用于插入输液和传感器组件的插入器器件的前透视图和侧透视图; 
图92A-92F概略示出用于操作插入器机构的一个实施例的时序序列; 
图92G示出在关闭位置中的具有制动件(catch)和压簧杠杆的插入器机构; 
图92H示出在打开位置中的具有制动件和压簧杠杆的插入器机构; 
图93A-93C示出用于将套管插入流体输送器件基部的时间序列; 
图94A-94C示出用于在将套管一致地连接到流动管线时将套管插入基部的时序序列; 
图95示出用于保持流体输送器件的粘结剂贴片的顶视图; 
图96概略示出在粘结剂贴片下面的流体输送器件的截面视图; 
图97示出用于保持流体输送器件的两个交叠粘结剂贴片的透视图; 
图98示出两个半圆形粘结剂贴片部分的顶视图; 
图99示出保持流体输送器件的两个半圆形粘结剂贴片部分的透视图; 
图100示出被患者移除的半圆形粘结剂贴片部分的透视图; 
图101示出使用多个粘结剂部件和系绳而附于患者的流体输送器件的透视图; 
图102A示出用于组装器件的夹具; 
图102B示出具有用于插入夹具的键孔的流体输送器件的基部; 
图102C示出利用夹具组装的流体输送器件的截面视图; 
图103A示出用于组装流体输送器件的凸轮引导件的透视图; 
图103B示出图103A的凸轮引导件的顶视图; 
图103C示出用于组装流体输送器件的夹销的透视图; 
图103D示出使用夹销和凸轮引导件组装的流体输送器件的实施 例; 
图104示出根据一个实施例的可塌陷储液器的截面视图; 
图105示出图104的储液器的透视图; 
图106A-106C示出根据一个实施例用于将隔膜固定到端帽以形成储液器的一系列步骤; 
图107示出根据一个实施例的储液器填充站; 
图108A-108B示出处于打开(108A)和关闭(108B)位置中的储液器填充站的实施例; 
图109A示出用于流体输送系统的实施例的数据采集和控制方案的一个实施例的框图; 
图109B示出用于流体输送系统的实施例的数据采集和控制方案的一个实施例的框图 
图110A示出描述根据一个实施例的流体输送器件的操作的流程图; 
图110B示出描述根据一个实施例的流体输送器件的操作的流程图; 
图111示出相互无线通信的用户接口和流体输送构件的框图; 
图112示出数据流视图,所述视图示出根据一个实施例的中间收发器的使用; 
图113示出根据一个实施例的中间收发器的框图; 
图114示出根据一个实施例用于通用患者接口的数据流视图; 
图115示出根据一个实施例的处于解耦状态的流体输送器件的非一次性部分和蓄电池充电器; 
图116示出根据一个实施例的处于对接状态的图115的流体输送器件的非一次性部分和蓄电池充电器;并且 
图117是描绘根据本发明实施例用于测量在泵冲程中输送的液体体积的过程的流程图。 
应该理解以上的图以及在其中描绘的元件未必按照一致的比例或者以任何比例绘制。 
具体实施方式
定义。如在本说明和所附权利要求中所使用的,下面的术语将具有所示意的含义,除非上下文另外要求: 
器件的“用户输入”包括器件用户或者其它操作员能够用来控制器件功能的任何机构。用户输入可以包括机械装置(例如开关,压钮)、用于与远程控制器通信的无线接口(例如RF、红外)、声学接口(例如带有语音识别)、计算机网络接口(例如USB端口)以及其它类型的接口。 
与用户输入有关的“按钮”,例如在下面讨论的所谓的“推注按钮(bolus button)”,可以是能够执行所需功能的任何类型的用户输入,并且不限于压钮。 
“警报器”包括能够用来向用户或者第三方发出警报的任何机构。警报器可以包括听觉警报器(例如扬声器、蜂鸣器、语音发生器)、视觉警报器(例如LED、LCD屏)、触觉警报器(例如振动元件)、无线信号(例如针对远程控制器或者看管者的无线发射)或者其它机构。可以同时地、同步地或者顺序地使用多个机构发生警报,包括备用机构(例如,两个不同的音频警报器)或者互补机构(例如,音频警报器、触觉警报器和无线警报器)。 
“流体”意指能够通过流动管线流动的物质,例如液体。 
“阻抗”意指器件或者流动管线对于从中流过的流体流的阻碍。 
“润湿”描述在正常流体输送操作期间与流体形成直接接触的构件。因为流体不限于液体,“润湿”构件并非一定变得湿润。 
“患者”包括从作为医疗处理的一部分的流体输送器件接收流体或者以其它方式接收流体的人或者动物。 
“套管”意指能够向患者灌输流体的一次性器件。如在这里使用的套管能够指代传统的套管或者针。 
“分析物传感器”意指能够确定在患者中存在分析物的任何传感器。分析物传感器的实施例包括但不限于能够确定任何滤过性毒菌的、寄生的、细菌的或者化学的分析物的存在的传感器。术语分析物包括葡萄糖。分析物传感器可以与流体输送器件中的其它构件(例如,非一次性部分中的控制器)和/或与远程控制器通信。 
“分配组件传感器”意指用于确定在分配腔室中存在的流体体积的机构。 
“尖锐物”意指能够刺穿或者戳穿动物皮肤,特别地是人的皮肤的任何物体。尖锐物可以包括套管、套管插入器件、分析物传感器或者分析物传感器插入器件。例如,在药筒中可以分别地提供或者可以一起地提供多个尖锐物。 
“一次性”指的是预期在固定时期中使用,然后被丢弃并且更换的部件、器件、部分或者其它类似的。 
“非一次性”指的是旨在具有不限使用时期的可再用部分。 
“贴片大小”意指足够小的尺寸,以致于在输送所述器件中含有的物质期间利用例如粘结剂或者带子可以被固定到患者皮肤并且作为医疗器件而被配戴。小到可以用作移植物的医疗器件属于该定义的范围。 
“通常存在的有限流阻”意指在流体输送的常规过程中,即,当不 存在错误状态(例如,堵塞)时存在的有限流阻。 
“无源”阻抗是在泵送循环期间不受有源控制的阻抗。 
“声学体积测量”意指使用例如在美国专利No.5,349,852和5,641,892中描述的声学技术以及在这里描述的技术的有关体积的定量测量。 
“温度传感器”包括用于测量温度并且向控制器传送温度信息的任何机构。该器件可以包括用于测量例如皮肤温度、AVS温度、环境温度和流体温度的一个或者更多温度传感器。 
在这里描述的器件、泵送机构、系统和方法的实施例涉及这样的流体输送,所述流体输送包括泵送和流体体积测量以及流体输送的致动和控制。所述器件的实施例包括用于流体输送的便携式或者非便携式器件。所述器件的一些实施例包括一次性的基部和非一次性的顶部。所述器件包括其中输液器件通过基部插入并且直接进入患者体内的实施例。这些器件实施例是贴片泵器件(patch pump device)。可以使用粘结剂、带子或者其它适当装置将贴片泵附着到患者。粘结剂可以具有保护性可剥离条带,所述条带可以在使用之前被移除以暴露出粘结剂。 
然而,在其它实施例中,流体输送器件是其中管线被连接到流动管线的便携式器件。一般地,通过套管将管线连接到患者。 
在其中使用一次性基部和非一次性顶部的一些实施例中,基部包括被润湿的部件,而非一次性顶部中所包括的部分通常为非润湿部件。 
泵送机构的各种实施例包括上游进口阀、泵送致动部件、下游出口阀和可移动部件。在一些实施例中,使用相同器件实现泵送致动部 件和下游阀门功能。泵送机构通过流动管线将流体从储液器泵送到出口。泵送机构通常与非加压储液器一起使用,然而,本发明范围不限于此。 
在流体输送系统的一个实施例中,所述器件包括分析物传感器壳体。分析物传感器通过器件基部的分析物传感器壳体被引入患者体内。在这些实施例中,也通过器件基部的管罩引入输液器件。在这些实施例中,所述器件作为贴片泵被用户配戴。 
所述系统一般地包括控制器,所述控制器可以包括无线收发器。因此,通过无线控制器器件可以完全地或者部分地控制所述器件。控制器器件可以通过无线通信从分析物传感器和/或流体输送器件接收信息。患者或者第三方能够使用所述控制器器件控制流体输送器件的功能。 
在流体输送器件的一个实施例中,所述器件是胰岛素泵并且所述分析物传感器是血液葡萄糖传感器。接收与输送的胰岛素体积(或者在一定时间期间泵冲程的数目)和血液葡萄糖数据有关的信息的控制器有助于用户对所述泵机构的致动时间表进行编程。 
在这里描述示例性的分配组件和体积感测器件。分配组件包括至少一个麦克风和扩音器。所述组件确定分配腔室中的体积改变以确定被泵送的流体体积。体积感测数据被用于确定流体输送器件的状态。因此,各种控制可以依赖于体积感测数据。 
在本发明的实施例中,用户经由用户接口配置流体输送器件,从而使得流体输送器件以适当方式输送流体。在一个实施例中,用户接口为可以与所述贴片无线通信的独立的手持式用户接口组件。所述贴片可以是一次性的,或者部分地一次性的。 
如上所述,所述器件实施例的示例性用途是用于向糖尿病患者输送胰岛素,但是其它用途包括输送任何流体。流体包括用于疼痛患者的镇痛剂、用于癌症患者的化学疗法以及用于代谢紊乱患者的酶。各种治疗流体可以包括小分子、天然产品、缩氨酸、蛋白质、核酸、碳水化合物、纳米颗粒悬浮液以及有关的在药物学方面可以接受的载体分子。治疗活性分子可以被改性以提高输送器件中的稳定性(例如,通过缩氨酸或者蛋白质的聚乙二醇化(PEG化))。虽然这里的示意性实施例描述药品输送应用,但是实施例可以被用于其它应用,包括用于高输出量的分析测量(例如缩微实验室技术应用和毛细管色谱分析)的试剂的液体分配。为了下面说明的目的,术语“治疗剂”或者“流体”被互换地使用,然而,在其它实施例中,能够使用如上所述的任何流体。因此,在这里包括的器件和说明不限于治疗用途。 
典型实施例包括用于保持流体供应的储液器。在胰岛素的情形中,储液器可以被方便地设为具有能够保持足以在一天或者多天中输送的胰岛素供应的尺寸。例如,储液器可以容纳大约1到2ml的胰岛素。对于大约90%的潜在用户,2ml胰岛素储液器可以相应于大约3天的供给。在其它实施例中,储液器能够具有任何尺寸或者形状并且能够适于容纳任何数量的胰岛素或者其它流体。在一些实施例中,储液器的尺寸和形状与储液器适于容纳的流体类型有关。流体储液器可以具有偏心的或者不规则的形状和/或可以被锁上从而防备错误安装或者使用。 
流体输送器件的一些实施例适用于糖尿病患者使用,因此,在这些实施例中,器件输送用于补充或者更换患者胰岛β细胞的胰岛素。适用于胰岛素输送的实施例试图通过提供基础水平的流体输送以及推注水平的输送而模拟胰腺作用。通过使用无线手持式用户接口能够由患者或者另一方设定基础水平、推注水平和定时。另外地,能够响应一体的或者外部的分析物传感器(例如葡萄糖监视器件或者血液葡萄糖传感器)的输出而触发或者调节基础和/或推注水平。在一些实施例 中,能够使用位于流体输送器件上的规定按钮或者其它输入装置由患者或者第三方触发推注。在另外的实施例中,推注或者基础水平能够通过位于流体输送器件上的用户接口被编程或者管理。 
根据本发明示例性实施例,图1示出配戴流体输送器件10并且握持用于监视和调节流体输送器件10的操作的无线用户接口组件14的患者12。用户接口组件14一般地包括用于输入信息(例如触摸屏或者小键盘)以及用于向用户传递信息的设备(例如LCD显示器、扬声器或者振动警报器)。流体输送器件一般足够小和轻,从而在数日中保持舒适地附着到患者。 
在图1中,流体输送器件10被示为配戴在患者12的手臂上。在其它实施例中,流体输送器件10可以被配戴在患者身上的其它位置处,在这些位置处患者身体能够有利地利用被输送的特殊流体。例如,流体可以被有利地输送到患者腹部区域、腰部区域、腿或者其它部位。 
现在参考图2A,示出流体输送器件10的概略示意图,该器件具有从分配组件120到泵送组件16的反馈环360。泵送组件16向分配组件120泵送流体;流体然后通过包括限流器340和输出部的出口组件17离开。所述输出部一般地包括套管并且通向患者。分配组件120可以包括弹性的可变容积分配腔室以及至少一个麦克风和扩音器,用于测量与随着时间通过所述输出部的流有关的参数。反馈环360使得可以基于由传感器进行的重复测量而调节泵送组件16的操作。限流器340在分配组件120和流动管线5010的输出部之间形成高阻抗。限流器340可以例如是窄孔管或者微管的一部分。 
现在参考图2B,在一个实施例中,泵送组件16将流体从储液器20泵送到分配组件120。 
现在参考图3,示出采用流体力学原理的另一实施例的框图。流 动管线310联接储液器20、泵送组件16、分配组件120以及出口组件17。出口组件17可以包括高阻抗限流器340和输液器件5010,例如套管。限流器340的输出被送至输液器件5010,以便输送给患者。限流器340具有比流动管线310的位于分配组件120上游的部分更高的流阻。因此,泵送组件16能够比流体能离开出口组件17的情况更快地将流体泵送到分配组件120中。分配组件120可以包括具有弹性壁的可变容积分配腔室122。在下面给出的实施例中,弹性壁是隔膜。隔膜材料的实例包括硅树脂、NITRILE以及具有用于如在这里所述的发挥作用的所需弹性和特性的任何其它材料。另外地,其它结构可以用于相同目的。当由于泵送组件16的作用而接收到流体供给时,隔膜弹性将允许腔室122首先膨胀并且然后提供驱动分配组件120的流体内容物经过限流器340到达患者所需的输送压力。当配备有适当传感器(在下面描述其实例)时,分配组件120可以测量通过可变容积分配腔室122的流体流并且可以通过反馈环360提供反馈以控制泵送组件16泵送或者部分地填充分配腔室122的定时和/或速率,由此以所需速率向患者输送所需剂量。 
再次参考图3,另外地,限流器340防止流体流超过规定流率。进而,因为通过泵送组件16、分配组件120和限流器340的交互作用而完成加压流体输送,因此能够采用非加压储液器20。 
仍然参考图3,反馈环360可以包括控制器501。控制器501可以包括处理器和用于致动泵送组件16以向分配组件120泵送流体的控制电路。控制器501从可以与分配组件120一体形成的传感器重复地接收与流体流有关的参数,并且使用该参数控制泵送组件16以实现通过输出部的所期望流动。例如,控制器501能够调节泵送组件16的致动定时或者程度,以实现所需的基础或者推注流率和/或输送所需的基础或者推注累积剂量。在确定泵送的定时或者程度时,控制器501可以使用传感器的输出(未示出)以估计流体流的速率、累积流量或者二者(以及很多其他量),并且然后基于所述估计确定适当的补偿行为。 在各种实施例中,可以脉冲地进行泵送,其能够以在10-9升每脉冲到微升每脉冲之间的任何速率进行输送。可以通过输送多个脉冲来实现基础或者推注剂量。(在下面示出并且描述基础和推注剂量的实例)。 
使用局部可塌陷的非加压储液器20可以有利地防止当储液器中的流体耗尽时在储液器中积累空气。储液器20可以通过隔膜(未示出)被连接到流动管线310。在通气储液器中空气积累能够防止流体从储液器20流出,特别是当系统被倾斜使得在储液器中含有的流体和储液器20的隔膜之间介入空气包时。在如可配戴器件的正常操作期间,希望系统被倾斜。图104-106C描绘了储液器的一个实施例的各种实施例和视图。另外地,在下面包括对储液器进一步的说明。 
现在参考图4A-4C,示出限流器340的各种实施例。现在参考图4A,限流器是模制流道340,它可以是在基部中的模制凹槽(未示出)。在一个实施例中,模制流道340的截面大致为0.009英寸。在该实施例中,限流器340被模制到设备中。现在参考图4B,作为限流器的可替代实施例示出微管340。在一个实施例中,微管具有大致0.009英寸的内径。模制流道和微管均使用具有小内径或者截面的长路径以给予流阻。现在参考图4C,示出了作为限流器340的精确孔板。在一个实施例中,精确孔板是具有激光钻孔的板。在可替代实施例中,可以使用在本领域中已知的任何流阻器件或者方法。与具有可能通常被认为在功能意义上形成无限流阻的有源下游阀的现有技术流体输送系统不同,限流器340形成有限流阻。与可能有时由于堵塞而被阻碍的现有技术系统不同,本发明的阻抗在正常情况时也是存在的。由于流阻的有限性,在包括分配腔室122的实施例中,即使当分配腔室122膨胀时,流体也可能通过出口泄露。 
图5-8概略示出分配组件120的示意性实施例的截面视图。应该理解,用于其它目的(例如工业过程)的流体输送属于本发明范围,并且以具体术语给出的说明仅仅是实例方式的。如图5所示,分配组 件120可以包括可变容积分配腔室122和传感器550。可变容积分配腔室122包括弹性分配膜片125,它允许腔室122根据进出分配组件120的流体流而膨胀和收缩。在本发明的某些实施例中,如将在这里进一步讨论地,可变容积分配腔室122可以被从分配组件120的其它元件拆离。利用双头箭头示出了允许腔室122膨胀和收缩的弹性分配膜片125的概念。计量腔室122被认为包括了在图5中利用箭头112指定的具有流体流特征的线路110的一部分。流体流112或者线路110的终止的位置或者特性均不限制如所附权利要求明确要求保护的本发明的范围。相比于当被泵送组件16泵送入腔室122时流体进入腔室122的情况,限流器340使得流体更加缓慢地离开分配腔室122。结果,当流体供给进入时,分配腔室122膨胀并且被加压。由于分配腔室122的膨胀而变形的分配膜片125提供了输送计量体积使其经过限流器340而到达出口组件17所需的作用力。如以上所讨论,传感器550重复地测量能够与弹性分配腔室122的容积相关的参数,例如位移、或者热力学变量或者容量。通过传感器550产生的体积测量可以用于通过反馈环控制泵送组件向分配腔室122泵送流体的定时和速率,从而适当的流体流被输送到出口组件17以及随后的管线,并且由此例如被输送到患者。传感器550可以采用例如声学体积感测(在下面更加详细地描述)或者用于确定体积或者体积相关参数的其它方法(光学或者电容性,作为其它实例)。声学体积测量技术是授予DEKA Products Limited Partnership的美国专利No.5,575,310和5,755,683以及于2006年4月5日提交的题目为“用于流动控制的体积测量方法”、系列号为No.60/789,243的共同待审临时美国专利申请的主题,它们均通过引用方式而被结合在这里。利用该实施例能够在纳升范围中进行流体体积感测,因此有助于高度准确和精确地监视与输送。也可以使用用于测量流体流的其它可替代技术;例如,基于Doppler(多普勒)的方法;使用与叶片阀或者挡板阀相组合的Hall(霍尔)效应传感器;使用应变梁(例如,与流体腔室上的柔性部件有关以用于感测柔性部件的挠曲);使用利用板的电容性感测;或者热的飞行时间法(thermal time of flight method)。 
现在参考图6到9,示出其中传感器利用声学体积感测(AVS)技术的实施例。首先的讨论参考在图6和7中描绘的实施例。分配组件120具有传感器,它包括基准腔室127以及通过端口128连接到固定容积腔室129的可变容积测量腔室121。虽然可以利用如图6和7所示的基准腔室127实施本发明,但是在本发明的某些其它实施例中,没有提供基准空间。应该理解,空间129作为术语在这里被称作是“固定的”,但是在声学激发时间尺度上其实际容积可以稍微改变,如当利用扬声器膜片驱动被称作固定空间129的区域时。流体通过弹性分配腔室122从泵送组件16流动到输入部123,并且流出出口通道124。由于高的下游阻抗,当流体进入分配腔室122时,分配膜片125膨胀到可变容积腔室121中。可以布置在印刷电路板126上的电子组件具有扩音器1202、感测麦克风1203和基准麦克风1201,用于测量与可变容积腔室121中的气体(通常为空气)相关的声学参数,腔室容积由分配膜片125的位置限定。由扩音器134感应的声波经由端口128通过固定容积腔室129行进到可变容积腔室121;声波还行进到基准腔室127。当分配膜片125随着流体流通过流动管线而移动时,可变容积腔室121中的空气体积改变,引起它的声学特性发生相关改变,这可以利用扩音器和麦克风1203探测。对于相同声学激励,基准麦克风1201可以探测固定基准空间127的声学特性。这些基准测量可以例如用于消除不精确性并且抵制声学激励中常见模式的不准确性以及其它错误。可以通过比较可变容积腔室121的测量容积与可变容积腔室121的初始容积而确定被移位的流体的体积。因为分配腔室122和可变容积腔室121的总容积保持不变,还能够估计分配腔室122的绝对容积。 
图6示出的实施例利用固有弹性的分配膜片125,而图7示出的实施例利用弹性分配弹簧130,所述弹性分配弹簧130当与分配膜片125组合时,增加了分配腔室122的弹性并且可以允许使用比在图5所示实施例中将要求的分配膜片更加柔顺(即,更低弹性的)的分配膜片125。分配弹簧130一般地定位成在膜片125的与分配腔室122相对 的一侧上邻近于分配膜片125。 
可替代地,为了减小来自麦克风的背景噪音,扩音器1202和感测麦克风1203可以经由分离的端口连接到可变容积腔室121。如在图8中概略示出,扩音器1202在经由扩音器端口6020声学地耦合于可变容积腔室121的固定扩音器空间6000中产生压力波。压力波从扩音器1202,通过扩音器端口6020行进到可变容积腔室121并且然后在被感测麦克风1203记录之前通过麦克风端口6010。扩音器端口6020可以包括具有向外展开的孔隙6030的管线部分6040。向外展开的孔隙6030用于对管线部分6040的所有轴向路径形成声波沿其行进的均匀长度。例如,管线部分6040可以具有柱体的几何形状,例如立柱体或者立圆柱体的几何形状。类似向外展开的孔隙也可以邻接管线部分以限定麦克风端口6010。与图6和7的AVS传感器不同,在图8的实施例中,从扩音器1202行进的压力波不具有到达感测麦克风1203的直接路径。因此,防止来自扩音器1202的压力波在不首先经过可变容积121的情况下直接冲击感测麦克风1203。因此麦克风接收到降低的背景信号并且实现了更好的信/噪比。另外地,可以在图6-8的实施例的任何一个中包括上搁板6050,从而有利地减少基准腔室127的容积。 
在将被进一步描述的实施例中,可以方便地分离分配组件的传感器和计量腔室部分,从而分配腔室是可拆卸的和一次性的。在此情形中,分配腔室位于贴片的一次性部分中,而传感器位于可再用部分中。分配腔室可以被弹性流体分配膜片(如在图6中作为122和124所示)界定。可替代地,如在图7中,分配腔室122可以被柔顺膜片125界定。在此情形中,分配弹簧130能够用于在分配腔室122上赋予弹性。当传感器550和分配腔室122被置于一起时,分配弹簧130覆盖柔顺分配膜片125。分配弹簧130和分配膜片125可以交替地被采用,作为限定分配腔室122的单一部分。 
如图9所示,示出分配组件的可替代实施例。在图9描绘的分配 组件120的实施例中,可变容积测量腔室121与分配腔室122共享柔顺壁(这里示为柔顺膜片125)。端口128声学地将测量腔室121耦合到固定容积腔室129,从而形成由标号1290总体标注的声学邻接区域。可压缩流体(通常为空气或者另一气体)填充声学邻接区域1290并且被驱动部件1214激发,该驱动部件1214本身由致动器1216驱动。驱动部件1214可以是扬声器的膜片,例如听力辅助扬声器的膜片,在该扬声器中,致动器1216例如是音圈螺线管或者压电元件。在本发明范围中,驱动部件1214还可以与致动器1216是同延的(coextensive),例如当驱动部件1214自身可以是压电元件时。驱动部件1214可以被包含在驱动器模块1212中,该驱动器模块在驱动部件1214的远离固定空间129的一侧上可以含有基准空间1220。然而,在本发明实践中一般不采用基准空间1220。 
基准麦克风1208被示为当信号麦克风1209声学地耦合至测量腔室121时与固定空间129声学连通。测量区域121的容积可以由一个或者更多麦克风1208、1209基于其位于声学邻接区域1290中的相应位置处测量的压力变化(或者,等效地,声学信号)而提供的电子信号所确定。可以通过将一个或者更多麦克风处的响应相位与声学激发相位进行比较或者与在另一麦克风的位置处的响应相位进行比较,来执行相位测量。由处理器1210基于相位和/或如下面所讨论的振幅测量来确定测量区域121的容积并且由此推断出分配腔室122的容积,所述处理器从电源1211获取电力,所述电源被代表性地示为蓄电池。 
为了精确输送微小量的治疗试剂,期望在每个泵冲程中输送小的但是非常准确计量的量。然而,如果在每一个泵冲程期间通过线路110泵送微小体积的流体,则计量过程要求极高的分辨率。因此,根据本发明的实施例,由传感器550以至少10纳升的分辨率测量容积的改变。在本发明的一些实施例中可以实现对于测量区域121的空置容积的0.01%分辨率的测量。根据本发明其它实施例,传感器550提供优于13纳升的分辨率。然而在其它实施例中,传感器550提供优于15纳升的 分辨率,并且在另外的实施例中,提供优于20纳升的分辨率。在这种情形中,声学邻接区域1290的总容积可以小于130μl,并且,在其它实施例中,小于10μl。 
根据本发明的各种实施例,可以使用对分配腔室122以及随后的可变容积腔室121(这里,也可以称为“计量空间”)的容积响应的在先建模,该在先建模基于由于进入输入部123的被泵送体积的流体填充分配腔室而进行的。虽然其它模型属于本发明范围,但是可以采用的一个模型将响应于被泵送的流入流体和具有固定流阻的出口的分配腔室122中的流体体积表达为基线体积VB和由峰值位移VD表征的指数衰减体积之和,从而在测量期间的计量腔室容积被表征为时间t的函数,如下: 
V = V D exp ( - t τ ) + V B
为了使得建模指数衰减(或者其它函数模型)的参数化拟合于一连串的声学测量,例如在图6到9中描绘的系统的响应推导如下。为了对响应进行建模,端口128的特征在于长度l和直径d。理想绝热气体的压力和体积能够通过PVγ=K相关联,其中K是由系统初始状态限定的常数。 
理想绝热气体定律能够通过根据平均压力P和体积V以及在那些压力之上的小的时变扰动p(t)v(t)表述: 
(P+p(t))(V+v(t))γ=K 
对该等式微分得到: 
p · ( t ) ( V + v ( t ) ) γ + γ ( V + v ( t ) ) γ - 1 ( P + p ( t ) ) v · ( t ) = 0
或者,简化得到: 
p · ( t ) + γ P + p ( t ) V + v ( t ) v · ( t ) = 0
如果声学压力水平比环境压力小得多,则所述等式能够被进一步简化为: 
p · ( t ) + γP V v · ( t ) = 0
应用理想气体定律,P=ρ RT,并且将其代替压力而给出以下结果: 
p · ( t ) + γRTρ V v · ( t ) = 0
能够根据声音速度
Figure BDA0000452847380000344
将其写为: 
p · ( t ) + ρa z V v · ( t ) = 0
而且,关于一定体积的声学阻抗被定义为: 
Z v = p ( t ) v · ( t ) = - 1 ( V ρa 2 ) s = - ρa 2 V · 1 s
根据一组模型,在假定端口中的所有流体实质上作为沿着轴向方向往复的刚性柱体而移动的情况下,对声学端口进行建模。假定通道(端口128)中的所有的流体以相同速率行进,假定所述通道具有恒定截面,并且进入和离开通道的流体导致的“端部效应”被忽略。 
假定是形式的层流摩擦,作用在所述通道中的流体物质上的摩擦作用力能够被写为: 
F = RρA 2 x · .
然后能够对于通道中的流体动力学写出二阶微分等式: 
ρLA x · · = ΔpA - RρA 2 x ·
或者,根据体积流率: 
v · · = - RA L v · + Δp A ρL
然后通道的声学阻抗能够被写为: 
Z p = Δp v · = ρL A ( s + RA L ) :
使用在上面定义的体积和端口动力学,能够通过下面的等式系统描述声学体积传感器系统(其中指标k代表扬声器,并且r代表共振器): 
p · 0 - ρa 2 V 0 v · k = 0
根据相同的约定, v &CenterDot; k > 0 &DoubleRightArrow; p &CenterDot; 1 < 0 并且 v &CenterDot; r > 0 &DoubleRightArrow; p &CenterDot; 1 > 0 ,
p &CenterDot; 1 + &rho;a 2 V 1 ( v &CenterDot; k - v &CenterDot; r ) = 0
另外, v &CenterDot; r > 0 &DoubleRightArrow; p &CenterDot; 2 < 0
p &CenterDot; 2 + &rho;a 2 V 2 v &CenterDot; r = 0
如果p2大于p1,则体积趋于沿着正方向加速。 
v &CenterDot; &CenterDot; r = - RA L v &CenterDot; r + A &rho;L ( p 2 - p 1 ) .
减少等式数目(将p0视为输入),并且代入 
v &CenterDot; k = V 0 &rho;a 2 p &CenterDot; 0 ,
p &CenterDot; 1 + V 0 V 1 p &CenterDot; 0 - &rho;a 2 V 1 v &CenterDot; r = 0
p &CenterDot; 2 + &rho;a 2 V 2 v &CenterDot; r = 0
v &CenterDot; &CenterDot; r = - RA L v &CenterDot; r + A &rho;L p 1 - A &rho;L p 2
使用这些等式给出一个简单表达式 
&rho;a 2 V 2 v &CenterDot; r = V 1 V 2 &CenterDot; ( &rho;a 2 V 1 v &CenterDot; r ) = V 1 V 2 p &CenterDot; 1 + V 0 V 2 p &CenterDot; 0
p &CenterDot; 2 + V 0 V 2 p &CenterDot; 0 + V 1 V 2 p &CenterDot; 1 = 0
V 0 p &CenterDot; 0 + V 1 p &CenterDot; 1 = - V 2 p &CenterDot; 2 - V 0 p &CenterDot; 0 + V 1 p &CenterDot; 1 p &CenterDot; 2 = V 2 ,
或者 
V 0 p 0 + V 1 p 1 = - V 2 p 2 - V 0 p 0 + V 1 p 1 p 2 = V 2
这些等式也能够以传递函数的形式表达。“交叉扬声器(cross-speaker)”传递函数,p1/p0为: 
s &CenterDot; p 1 + V 0 V 1 s &CenterDot; p 0 - &rho;a 2 V 1 s &CenterDot; v r = 0
s &CenterDot; p 2 + &rho;a 2 V 2 s &CenterDot; v r = 0
s 2 &CenterDot; v r = - RA L s &CenterDot; v r - A &rho;L p 1 + A &rho;L p 2
p 2 = - &rho;a 2 V 2 v r
s 2 v r = - RA L s &CenterDot; v r + A &rho;L ( - &rho;a 2 V 2 . ) v r - A &rho;L p 1
( s 2 + RA L s + Aa 2 LV 2 ) v r = - A &rho;L p 1
v r = - A / &rho;L s 2 + RA / Ls + Aa 2 / LV 2 p 1
或者 
p 1 p 0 = - V 0 V 1 s 2 + 2 &zeta; &omega; n s + &alpha; &CenterDot; &omega; n 2 s 2 + 2 &zeta; &omega; n s + &omega; n 2
其中: 
&omega; n 2 = a 2 A L ( 1 V 1 + 1 V 2 ) ; &zeta; = RA 2 L &omega; n ; 并且 &alpha; = V 1 V 1 + V 2 .
类似地,基于对端口128的任一端部的测量的“交叉系统”传递函数为p2/p0,由下式给出: 
s &CenterDot; p 1 + V 0 V 1 s &CenterDot; p 0 - &rho;a 2 V 1 s &CenterDot; v r = 0
s &CenterDot; p 2 + &rho;a 2 V 2 s &CenterDot; v r = 0
s 2 &CenterDot; v r = - RA L s &CenterDot; v r - A &rho;L p 1 + A &rho;L p 2
p 1 = &rho;a 2 V 1 v r - V 0 V 1 p 0
s 2 v r = - RA L s &CenterDot; v r - A &rho;L &CenterDot; &rho;a 2 V 1 v r - A &rho;L ( - V 0 V 1 p 0 ) + A &rho;L p 2
v r = AV 0 &rho;LV 1 s 2 + RA L s + Aa 2 LV 1 p 0 + A &rho;L s 2 + RA L s + Aa 2 LV 1 p 2
s &CenterDot; p 2 + &rho;a 2 V 2 s &CenterDot; [ AV 0 &rho;LV 1 s 2 + RA L s + Aa 2 LV 1 p 0 + A &rho;L s 2 + RA L s + Aa 2 LV 1 p 2 ] = 0
[ s 2 + RA L s + Aa 2 LV 1 + Aa 2 LV 2 ] p 2 = - Aa 2 LV 2 &CenterDot; V 0 V 1 p 0
p 2 p 0 = - V 0 V 1 Aa 2 LV 2 s 2 + RA L s + Aa 2 LV 2 &CenterDot; V 1 + V 2 V 1
p 2 p 0 = - V 0 V 1 &alpha;&omega; n 2 s 2 + 2 &zeta; &omega; n s + &omega; n 2
使用交叉系统相位的体积估算 
类似地,使用相同原理,易于推导传递函数,利用固定容积腔室129经由端口128与之联接的可变容积腔室121中的压力表示固定容积腔室129中的压力。特别地,所述传递函数为: 
p 2 p 1 = 1 V 2 L p a 2 A p s 2 + RV 2 a 2 s + 1 = a 2 A p V 2 L p s 2 + RV 2 a 2 a 2 A p V 2 L p s + a 2 A p V 2 L p = &omega; n 2 s 2 + RA p L p s + &omega; n 2
在前述的任一情形中,系统共振频率可以被表达为可变容积V2的函数: 
&omega; n 2 = a 2 A L ( 1 V 1 + 1 V 2 ) , or 1 V 2 = &omega; n 2 L a 2 A - 1 V 1 .
因为所有的其它参数都是已知的,因此能够例如基于共振频率计算可变容积V2,但是推导V2的其它方法可能是有利的,并且在本申请中进一步描述。在该等式中不是常数的一个参数是声音速度a,它可以基于有关温度被计算出或者以其它方式被推导或者测量。 
如所述那样,可以采用各种策略以询问所述系统,从而推导体积V2。根据本发明的某些实施例,由驱动部件1214以单一频率激发所述系统,同时监视一个或者多个转换器(麦克风1208和1209,图9)的响应。作为复信号捕捉所述响应,保持压力变化的振幅和相位。有利的是,单一询问频率接近系统在中间冲程中的共振,这是因为由此实现了在用来清空腔室的整个范围中伴随体积的最大相位改变。 
可以校正信号麦克风1208的响应,以消除由于激发扩音器1202(示于图6)或者驱动部件1214(示于图9)的依赖频率的特性而引起的共模效应。作为麦克风信号的复数比(complex ratio)而获得的校正信号可以被表达为mi,其中,指标i代表信号的连续时间样本。 
类似于二阶机械赫姆霍兹共振器(Helmholtz resonator),以传递函数的形式表达,所述信号可以被表示为: 
m i &ap; - V 0 V 1 A&gamma;RT LV 2 s i 2 + &lambda;A L s i + A&gamma;RT LV 2 &CenterDot; V 1 + V 2 V 1 = - V 0 V 1 &CenterDot; A&gamma;R L&omega; c 2 &CenterDot; T i V 2 &CenterDot; &alpha; &epsiv; v , i s i 2 &omega; c 2 + A&lambda; L&omega; c &CenterDot; &epsiv; &lambda; &CenterDot; s i &omega; c + A&gamma;R L&omega; c 2 &CenterDot; T i V 1 &CenterDot; ( &epsiv; v , i + &Psi; 1,2 ) &epsiv; v , i = - &kappa; 0 , i &alpha; &epsiv; v , i s &OverBar; i 2 + &psi; 1 &CenterDot; s &OverBar; i &CenterDot; &epsiv; &lambda; + &psi; 0 , i &Psi; 1,2 + &epsiv; v , i &epsiv; v , i = - &kappa; 0 , i &alpha; s &OverBar; i 2 &epsiv; v , i + &psi; 1 s &OverBar; i &epsiv; &lambda; &epsiv; v , i + &psi; 0 , i ( &Psi; 1,2 + &epsiv; v , i ) = - &kappa; 0 , i &alpha; [ &psi; 0 , i ( &Psi; 1,2 + &epsiv; v , i ) - &omega; &OverBar; 1 2 &epsiv; v , i ] + &iota; &CenterDot; &psi; 1 &omega; &OverBar; i &epsiv; &lambda; &epsiv; v , i &CenterDot; [ &psi; 0 , i ( &Psi; 1,2 + &epsiv; v , i ) - &omega; &OverBar; i 2 &epsiv; v , i ] - &iota; &CenterDot; &psi; 1 &omega; &OverBar; i &epsiv; &lambda; &epsiv; v , i [ &psi; 0 , i ( &Psi; 1,2 + &epsiv; v , i ) - &omega; &OverBar; i 2 &epsiv; v , i ] - &iota; &CenterDot; &psi; 1 &omega; &OverBar; i &epsiv; &lambda; &epsiv; v , i = - &kappa; 0 , i &alpha; [ &psi; 0 , i &Psi; 1,2 + ( &psi; 0 , i - &omega; &OverBar; i 2 ) &epsiv; v , i ] + &iota; &CenterDot; &kappa; 0 , i &alpha; &psi; 1 &omega; &OverBar; i &epsiv; &lambda; &epsiv; v , i [ &psi; 0 , i &Psi; 1,2 + ( &psi; 0 , i - &omega; &OverBar; i 2 ) &epsiv; v , i ] 2 + &psi; 1 2 &omega; &OverBar; i 2 &epsiv; &lambda; 2 &epsiv; v , i 2
这里,归一化变量已被引入,从而保持有关参数位于阶次单位的在计算方面有用的动力学范围内。最终表达式通过实部和虚部除以公分母来表达。取得实部μ与虚部ν的比率,(即,相位余切), 
&mu; i v i &ap; - ( &psi; 0 , i - &omega; &OverBar; i 2 ) &epsiv; v , i + &psi; 0 , i &Psi; 1,2 &psi; 1 &omega; &OverBar; i &epsiv; &lambda; &epsiv; v , i
误差可以被定义成: 
E = 1 M &Sigma; [ &mu; i D i + v i N i ] 2
其中N和D分别地代表所述模型的分子和分母。 
如果关于每一个模型参数最小化所述误差,则实现了最佳拟合。可以采用任何方法拟合模型参数。在本发明的一个实施例中,采用梯度下降方法寻找最小值: 
&PartialD; E &PartialD; &epsiv; &lambda; = 2 M &Sigma; &psi; 1 &omega; &OverBar; i &epsiv; v , i D i e i
&PartialD; E &PartialD; &epsiv; b = 2 M &Sigma; ( &mu; i &PartialD; D i &PartialD; &epsiv; b + v i &PartialD; N i &PartialD; &epsiv; b ) e i = 2 &Sigma; ( &mu; i &PartialD; D i &PartialD; &epsiv; v , i + v i &PartialD; N i &PartialD; &epsiv; v , i ) e i &PartialD; &epsiv; v , i &PartialD; &epsiv; b
&PartialD; D i &PartialD; &epsiv; v , i = &psi; 1 &omega; &OverBar; i &epsiv; &lambda;
&PartialD; N i &PartialD; &epsiv; v , i = &psi; 0 , i - &omega; &OverBar; i 2
&PartialD; &epsiv; v , i &PartialD; &epsiv; b = 1
&PartialD; E &PartialD; &delta; d = 2 M &Sigma; ( &mu; i &PartialD; D i &PartialD; &epsiv; v , i + v i &PartialD; N i &PartialD; &epsiv; v , i ) e i &PartialD; &epsiv; v , i &PartialD; &delta; d
&PartialD; &epsiv; v , i &PartialD; &delta; d = exp ( - t i &epsiv; &tau; / &tau; )
&PartialD; E &PartialD; &epsiv; &tau; = 2 M &Sigma; ( &mu; i &PartialD; D i &PartialD; &epsiv; v , i + v i &PartialD; N i &PartialD; &epsiv; v , i ) e i &PartialD; &epsiv; v , i &PartialD; &epsiv; &tau;
&PartialD; &epsiv; v , i &PartialD; &epsiv; &tau; = &delta; d - t i &tau; exp ( - t i &epsiv; &tau; / &tau; )
对于本发明的每一特定应用,获得了每一个连续时域样本的间隔,并且用于拟合时域模型参数而采样的间隔数目被有利地优化。当流体以缓慢的但是相对恒定的速率流动时,如在基础胰岛素输送中,已经发现以从τ/3到3τ的周期进行采样是有效的。在另一极端情形中,当输送相对大推注的流体时,在指数衰减时间常数的时间尺度上,流体可能仅在短时期内存在于分配空间122中。在此情形中,在特征衰减时间的更短的时段上进行采样。 
根据本发明的优选实施例,基于以单一激发频率进行的交叉系统相位测量,根据对体积-时间的模型的拟合来确定通过分配空间122分配的流体体积。而且,在泵冲程的初始部分期间,参考图117示出的流程图,与测量协议相结合进行初步测量以校准系统操作,如现在所描述的那样。由标号1170总体标注的计量过程有利地节省计算机资源并且降低功耗,由此延长在充电或者更换电源1211(示于图9)之间的使用时间,同时通过频率校准提供了以每冲程具有上述分辨率的方式输送流体所要求的测量准确度。 
在每一个泵冲程之前或者在其开始1171时,或在这两种情况下,处理器1210启动AVS系统的自校准相位1172。不进行测量直至由于致动泵引起的电子瞬变已经显著衰减。在步骤1173中,以一连串的频率,麦克风和扬声器增益被设定,并且驱动部件1214被致动,其中通常采用大体靠近邻接声学区域1290(或者在这里被称作“声学腔室”)共振的五个频率。一般地采用在6-8kHz范围内的频率,但是使用任何频率均属于本发明范围。在每一个相继频率致动开始时,在大致5ms的时期内,数据采集被延迟,直至声学瞬变已经基本衰减。 
对于大致64次声学循环的持续时间,如下采集数据:在步骤1174中对由温度传感器132(图70B示出)提供的温度读数采样,并且信号麦克风1209相对于基准麦克风1208的输出信号的比率的用ρ和ι表示的实部和虚部分别被采样。为了描述AVS系统的目的,信号的复数比,或者麦克风信号相对于所述基准的其它功能性组合在这里可以被称为“信号”。 
基于在每个频率大致200ms的时期上进行的在每一个频率下的测量,对于在每一个频率下的信号实部和虚部的每一个并且对于温度读数而推导出一组平均值和方差。在步骤1175中对这些数值的分析使得可以确定出误差是否位于规定范围中。异常传递函数可以有利地示意系统故障,所述故障包括但不限于麦克风或者其它传感器、扬声器、转换器、电子器件、机械构件、流体入口中的故障、不良声学密封、过度环境噪音,以及过度冲击和振动。另外地,在步骤1176中确定信号的相位角度作为频率函数的函数依赖关系。信号的相位角度,即其虚部与实部比率的反正切,可以被用作相位测量,然而在本发明范围内可以使用任何相位测量。可以通过相位与频率的多项式拟合或者以其它方式推导所述函数依赖关系。在步骤1177中,基于所述多项式拟合,或者以其它方式,在体积测量频率下确定相位对频率的斜率,并且进行体积测量。另外地,并且重要地,相位对频率的异常斜率示意在分配腔室122中含有的流体中存在气泡。 
对于每一个泵冲程的后继部分,基本在单一频率下致动驱动部件1214,由此在该频率下在声学上激发声学邻接区域1290中的气体。在大致64个循环的规定采样间隔中,一般基于信号麦克风1209相对于基准麦克风1208的输出信号复数比的信号数据被收集并且平均化。对于每一个采样间隔记录所述信号的实部和虚部以及温度数据。基于被采样和采集的数据,对时域模型进行拟合。在本发明各种实施例中,如上所述,采用梯度下降方法,从而在每一个泵冲程期间使拟合模型参数,即可变容积腔室121的基线容积VB、峰值位移VD以及衰减时间τ中的误差最小化,由此提供通过分配腔室122输送的流体体积。 
现在参考图10,分配弹簧130可以具有与膜片互补的螺旋或者扇形形状并且可以具有多个螺旋凹槽131。如所示弹簧的实施例能够在膜片上施加大致均匀的作用力。这种大致均匀的作用力有助于膜片当其膨胀时保持大致凹形的形状。凹槽131允许空气自由地通过弹簧,因此大多数空气未被滞留在弹簧和膜片之间。 
现在参考图11A和11B,对于典型基础输送脉冲(图11A)并且对于典型推注输送(图11B)示出分配腔室122(图5所示)的容积的动力学测量以及所计算的从分配腔室122排出的累积容积的实例。如从图11A可见,致动泵送组件16引起分配腔室122在大约2秒时间内从大约0到大约1.5μl膨胀,如声学体积传感器550所测量的。注意到弹性分配腔室122在大约30秒的时期内收缩并且通过高阻抗输出从腔室122排出它的流体,其中指数衰减动力学关系由大约6秒的半衰期(t1/2)表征。从利用由传感器550进行的测量中计算从分配腔室122输出的累积体积,并且也注意到它指数地增长至大约1.5μl。能够发现高阻抗输出在致动泵组件和输送大部分移位流体之间引入延迟。能够考虑由分配腔室122施加的弹性作用力以及输出的阻抗程度选择系统的t1/2特性。在各种实施例中,时间常数可以改变以节电并且消除漂移问题。时间常数可以例如是t1/2=2秒或者t1/c=2秒。 
图11B示出利用流体输送器件10的推注流体输送的动力学分布。快速的相继的大约29次泵致动(即,脉冲)均从流体源将流体移到弹性分配腔室122中,因此引起由声学体积测量传感器550测量的参数发生相应的改变。能够注意到分配腔室122的容积在第一个泵脉冲上膨胀到大约1.5μl,该数值类似于在图11A中观察到的数值。在短于实现分配组件120完全排放所要求的时期的脉冲间隔下的另外的脉动泵送下,分配腔室122容积进一步膨胀;该膨胀达到最大大约6μl。在大约85秒之后泵脉动停止并且发现腔室122的容积以指数衰减动力学关系而降低,从而在停止泵送之后以大约30秒的时间完全排放它所含的流体。用于这个最终排放的t1/2与用于图11A中所示的基础输送的基本相同。注意到所计算的累积输出体积在泵送期间以大致线性动力学行为升高并且当停止泵送时达到稳定水平。 
在所描述的系统中,通过体积测量而非通过压力测量探测故障状态,因此,可以在几秒内确定故障。图11C-11F示出了图5-7的传感器550探测各种类型的故障状态。参考图5-7描述关于图11C-11F的所有的说明。 
图11C示出在正常操作状态中关于泵送脉冲的传感器550输出相对于时间的动力学分布。作为对照,图11D示出分配组件120下游发生堵塞的预期结果;传感器550快速地探测到在分配腔室122中的流体的增加的(或者是没有降低的)体积。 
在图11E-11F中示出低体积状态。在图11E中,达到大致最大的传感器信号,随后为过快的衰减;该状态可以示意泵16、流动管线310或者分配组件120中的内部泄露。图11F的动力学分布具有低峰值体积信号并且可以代表泵故障、空置储液器20或者位于分配腔室122上游的堵塞。分配腔室122响应于泵致动的延迟膨胀也可示意流动管线310中的问题。传感器550还可能能够探测流体中的气泡。能够响应于 故障状态的探测而致动警报器。 
图12示出描绘声学体积感测和补偿(相应于图2A-3的控制环360)的循环的流程图。传感器可以基于由泵送循环诱发的可变容积腔室121中的循环变化的幅度来测量从器件10分配的流体量。例如,传感器550可以重复获取共振可变容积腔室121和基准空间腔室127的声学频谱(步骤2611)并且维持对于每一个泵送脉冲的参数,该参数被更新为结合可变容积腔室121中的气体的体积降低。相应地,被更新的参数表示已经进入分配腔室122中的净流体量。当在脉冲之间存在充分延迟时,进入分配腔室122中的流体大致等于已被器件10分配的体积。可替代地,传感器550能够重复测量在可变容积腔室121中的气体体积增加,以确定由器件分配的量(如果在脉冲之间存在充分的延迟)。声学频谱与查询表格中的模型频谱相比较,该模型频谱可以相应于具有气泡、没有气泡或者具有变化尺寸的气泡的分配腔室122的任何一个或者所有的(步骤2621)。查询表格可以含有通过实验获取的、使用模型确定的或者根据工作经验确定的数据。查询表格可以具有代表含有变化气泡和/或代表关于分配腔室122的多个膨胀程度的正常状态的数据。如果频谱和更新的总和拟合了正常流动模型(步骤2631),则获取另一声学频谱并且在步骤2611处重复循环。如果频谱和/或更新的总和并不拟合正常流动模型,则确定存在低的或者堵塞流动(步骤2641)。通过利用低于预测或者设定数值,或者低于二者的更新的总和,可变容积腔室121的恒定超范围的体积可以示意低的或者堵塞流动。如果探测到低的或者堵塞流动状态,则警报器将被触发(步骤2671)。警报器可以包括听觉信号、振动或者这二者。如果没有发现低的或者堵塞流动状态,则所述器件确定所述频谱是否拟合相应于在分配腔室122中具有气泡的状态的模型(步骤2661)。如果确定存在气泡,则启动可以包括警报和/或补偿行为的反应,所述补偿行为可以包括临时增加泵送速率(步骤2651)并且所述循环在步骤2611处再次开始。如果确定不存在气泡,则警报器被触发以示意未被确定的故障状态(步骤2671)。本发明的实施例也可以利用如在共同未审美国专 利申请系列号No.60/789,243中披露的使用AVS技术的气泡探测,所述专利申请通过引用方式而被结合在这里。 
图2A-3的泵送组件16将流体从储液器20促动到分配组件120。当使用根据图6-7的分配组件时,不必使用高精度泵,因为由分配组件120提供给泵送组件16的反馈允许基于被输送体积的准确测量而调节泵送组件16。各个泵送脉冲可以具有足够低的体积以允许基于反馈进行精确补偿。因此能够采用很多不同的泵送组件16方案。在下面描述泵送组件16的各种可能的实施例。 
图13和14概略地示出在根据本发明实施例的流体输送器件中的一些构件的可替代实施例。图13示出带有泵送组件16的流动管线310,所述流动管线具有位于上游单向阀21和下游单向阀22之间的泵送元件2100。泵送元件2100可以使用致动器以使流动管线的一个部分变形,从而在流动管线310中产生压力。上游单向阀21抑制从泵送元件2100朝向流体源(未示出)的倒流,而下游单向阀22抑制从体积感测腔室120到泵送元件2100的倒流。结果,流体沿着出口组件17的方向被驱动,该出口组件在一个实施例中包括高阻抗通道。 
在图14示出的可替代实施例中,通过组合阀门泵2200执行泵送元件的功能,即,在流动管线310以及上游单向阀21中产生压力。因此,在图14实施例中的泵送组件16由两个构件形成,即,组合阀门泵2200和下游单向阀22,而非用于图13实施例中的三个构件。可以使用泵送组件16的其它实施例。在阀门泵2200中阀门和泵送功能的组合可以由各种机构实现,其中一些在下面参考图15A-16以及22-56进行描述。 
在下面描述的很多实施例中,用于进口阀21的提升阀、用于出口阀22的提升阀以及泵送致动部件54均直接地或者间接地(例如,如在图50-56中)与流动管线310连通,从而这些元件的每一个均能够形 成各种流体压力或者对于各种流体压力作出反应。如在上面所指出,上游和下游阀(这里也可以称为进口和出口阀)是单向阀。在其它类型的单向阀中,所述阀门可以是火山阀(volcano)、挡板阀、止回阀或者鸭嘴阀,或者是朝向器件输出偏流的其它类型的阀门。在于1993年1月12日授予Dean L.Kamen的美国申请No.5,178,182中披露了火山阀的实例,该美国专利通过引用方式结合在这里。 
在图15A-15D示出的实施例中,泵送组件包括进口阀21和出口阀22,其中每一个阀均包括流体进口、流体出口和可移动部件(对于每一个阀门,可移动部件是隔膜2356的一个部分)。泵送组件还包括泵送元件2100。泵送元件位于进口阀21下游以及出口阀22上游。在下面的说明中,出口阀从关闭位置开始,即,流体不流过出口阀。然而,在当流体提供足够的压力时,通过在隔膜和出口阀的提升阀9221上施加压力以打开阀门,使得流体压力打开所述出口阀,并且流体然后能够流过出口阀22。在单一机械动作既堵塞泵进口又进而迫使通过泵出口流动的意义下,图15A到15D的实施例可以被认为是组合阀门泵(如图14中的物件2200)。 
这个泵送装置具有将移动部分和润湿线构件分隔到柔性屏障隔膜2356的相对侧的优点。结果,移动部分可以位于可再用构件中而润湿部分(流动管线310)可以位于一次性构件中。 
在泵送机构的优选实施例中,流体源是非加压储液器。当进口阀的可移动部件处于打开位置并且在泵送腔室中存在负压力时,存在从储液器朝向进口阀抽吸流体的压力差。可以利用泵送腔室中的隔膜的弹性形成该负压力。在一个可替代实施例中,可内置于隔膜中的弹簧可以用于辅助泵送腔室中的隔膜的弹回。非加压储液器可以是可塌陷的,从而当从储液器抽吸流体时,储液器中相应的塌陷减少它的容积。结果,防止在储液器中形成负压力或者空气。 
在泵送机构的优选实施例中,在进口阀关闭之后,压力被施加到泵送腔室以从泵送腔室朝向出口阀促动流体。通过泵送运动形成的压力打开出口阀并且允许流体流过出口阀的流体出口。 
可移动部件可以是能够如上所述发挥作用的任何部件。在一些实施例中,可移动部件是柔性隔膜或者弹性泵送膜。在其它实施例中,可移动部件是球形刚性结构或者能够防止流体从流体路径中的开口流出的另一物体。 
在实践中,可以在使用之前灌注泵送机构。因此,泵送机构通过多个冲程进行循环,从流动管线排出空气,直至流动管线中的大部分或者所有的空气被排出。因为在泵送腔室外部具有的但又处于阀门之间的流体体积小,因此在这里披露的很多泵送机构具有“自灌注”的能力。当泵促动泵腔室中的空气时,它基本形成足够的压力以送过出口阀。随后的返回冲程能够因此形成足够的负压力以使得泵从储液器抽吸液体。如果泵的“死”容积太大,则泵送腔室中的空气不可以形成足够的压力以从出口阀逸出。结果,泵可能停止操作。 
图15A-15D、16和22-56示出泵送机构的多个实施例。现在参考图15A-15D,示出泵送机构的一个实施例,以示例泵送过程中的多个步骤:1.流体经过进口阀21(如图15B所示);2.进口阀关闭(如图15C所示);和3.当流体压力打开出口阀22时泵送致动部件54朝向下游促动流体并且使其流过流体出口(如图15D所示)。 
图15A-15D的泵送机构包括可移动部件,所述可移动部件在该实施例中是柔性隔膜2356的一个部分。进口阀和出口阀包括用作阀门堵塞器的提升阀9221、9222。提升阀9221、9222和泵致动部件54的每一个均包括弹簧8002、8004、8006。泵板8000接附到泵致动部件54和进口提升阀9221并且用作其各自弹簧8004、8002的终点。 
术语“提升阀”用于表示朝向可移动部件(即,隔膜)施加压力以影响隔膜位置的部件。虽然可以使用其它设计,在下面描述利用具有机械优点的结构和原理的弹簧加载提升阀阀门的一些特殊实例(结合图50-56)。然而,除了提升阀之外的机构能够用于执行相同功能。在图15B-15D中,进口阀21包括流体进口和流体出口、隔膜2356的一部分、以及提升阀9221。出口阀22包括流体进口、流体出口、隔膜的一部分和提升阀9222。 
在图15A-15D示出的实施例中,通过可以是刚性的或者具有一定柔性(优选地柔度低于隔膜2356)的结构(图15A中的物件9310)来限定流体路径310。如图15A所示,壳体结构9310限定了阀门腔室9321、9322和泵送腔室2350;所有的这三个腔室均位于流体路径310中。 
现在参考图15B-15D,进口阀21、出口阀22和泵元件2100均具有流体进口和流体出口。泵送致动部件54具有流体在离开进口阀之后在此处流动的泵送腔室2350。泵送致动部件54在隔膜2356上施加压力,在流动管线中形成正压力。 
如图15B-15D所示(并且对于用于图50-56所示出口阀的阀座4070类似),当隔膜未被进口阀的提升阀9221致动时,进口阀21中的阀座9121优选地与隔膜2356隔开。 
流动管线310由隔膜2356局部地限定。在该实施例中,隔膜2356将泵送机构的一些部分与流体分离。因此,流动管线310被润湿并且泵送致动器54和阀门提升阀9221、9222不被润湿。然而,泵送组件的可替代实施例不需要包括与流动管线310接触的隔膜2356。相反,不同的可移动部件可以被用于阀门和/或泵。在另外的实施例中,流动管线310的仅仅一些部分与泵送机构分离,因此局部地润湿泵送组件。 
进口提升阀9221包括端部8018,该端部表示接触流动管线310的隔膜部分的进口提升阀的表面区域。泵送致动部件54包括接触流动管线310的隔膜部分的端部8012。同样地,出口提升阀22包括接触流动管线310的隔膜部分的端部8022。阀门提升阀的端部8018、8022在隔膜2356的其相应区域上施加压力,阻挡或者打开流动路径310的相应部分。压力致动部件的端部8012也在隔膜的相应区域上施加压力,从而引起通过流动管线310的流动。 
泵送致动部件54被柱塞偏压弹簧8004围绕。柱塞偏压弹簧8004具有位于泵板8000和位于8014处的终点、以及还保持泵送致动部件的支撑结构。 
进口提升阀21被进口提升阀弹簧8002围绕,但是在可替代实施例中,进口提升阀自身是弹性的并且因此提供弹簧的功能。进口提升阀弹簧8002具有位于泵板8000处的以及靠近进口提升阀9221的端部8018的终点。 
出口提升阀9222被无源出口提升阀弹簧8006围绕。出口提升阀弹簧8006具有位于出口提升阀板8024的终点以及靠近出口提升阀9222的端部的唇凸8020。 
在每一情形中,弹簧8002、8004、8006在相应的端部之前终止并且不干扰接触隔膜2356的表面区域8018、8012、8022。 
在优选实施例中,流体泵送器件还包括随着温度改变形状的至少一个形状记忆致动器278(例如,导电形状记忆合金导线)。可以利用加热器,或者更方便地通过施加电流而改变形状记忆致动器的温度。图15B-15D示出具有一个形状记忆致动器278的实施例,然而,在其它实施例中(在下面描述)可以存在多于一个的形状记忆致动器278。在一个实施例中,形状记忆致动器是利用镍/钛合金构造的形状记忆导 线,例如NITINOLTM或者
Figure BDA0000452847380000511
然而,在其它实施例中,也可使用能够产生作用力的任何器件,例如螺线管。在某些实施例中,形状记忆致动器278具有大约0.003英寸的直径以及大约1.5英寸的长度。然而,在其它实施例中,形状记忆致动器278可以由能够利用热量收缩的任何合金制成(并且膨胀可以通过在合金上施加作用力从而将合金拉伸到初始长度的机构辅助进行,即弹簧,但是这种机构不是必须的),从而如在这里描述的实施例中那样致动泵送机构。在某些实施例中,形状记忆致动器278的直径可以从0.001英寸到所需的任何直径并且长度可以是所需的任何长度。通常,直径越大,可获得的收缩作用力越高。然而,用于加热导线所要求的电流通常将随着直径而增加。因此,形状记忆合金278的直径、长度和组分可以影响用于致动泵送机构所需的电流。与形状记忆致动器278的长度无关,致动作用力大致恒定。致动作用力的增加能够通过增加形状记忆致动器278的直径产生。 
形状记忆致动器278通过连接器8008连接到泵板8000。在下面更加详细地描述连接器8008。形状记忆致动器278通过终点连接器8010连接到流体泵送器件。根据其中使用泵送机构的器件或者系统,终点连接位置将改变。在下面更加详细地描述终点连接器8010。 
图15B-15D示出如以上讨论已经被灌注的流动管线310和泵送机构。现在参考图15B,进口阀21打开,并且泵送致动部件54没有压在隔膜2356上。出口阀22处于关闭位置中。形状记忆致动器278处于膨胀位置中。在该配置中,流体被从储液器(未示出)抽吸到进口阀21流体进口。(虽然示出作为进口阀区域中的隔膜中的隆起,在该步骤中抽吸流体可以引起隔膜凹陷,或者隔膜不发生变形)。当进口提升阀处于打开位置时,流体能够从流体进口流动到流体出口并且进入泵送腔室2350。此时,出口提升阀端部8022被紧紧地压在隔膜2356上并且密封出口阀22。 
下面参考图15C,电流已被施加到形状记忆致动器278,并且形状记忆致动器从开始长度朝向所需最终长度收缩。形状记忆致动器278的收缩朝向流动管线310拉动泵板8000。进口提升阀9221和泵送致动部件54均被连接到泵送板8000。板8000的运动朝向隔膜2356拉动进口提升阀9221和泵送致动部件54。如图15C所示,进口提升阀端部8018被牢固地压在隔膜2356上,将隔膜密封到阀座9121并且关闭进口阀21。(进口提升阀的运动能够促动进口阀门腔室中的,即图15A中的物件9321中的小量流体流过进口阀21的流体进口或者流体出口。) 
同时地,泵送致动部件54朝向泵送腔室2350开始它的路径。在该过程期间,当进口提升阀弹簧8002被压缩时(此时,进口提升阀端部8018被牢固地压到流动管线310),泵板8000和泵送致动部件54继续朝向流动管线310行进。进口提升阀弹簧8002允许泵板8000随着泵致动部件54继续朝向流动管线310移动,即使当进口提升阀9221不再能够行进时。 
现在参考图15D,泵送致动部件54压到隔膜2356的在泵送腔室2350之上的区域并且流体被泵送,从而增加泵送腔室2350中的流体的压力。出口提升阀端部8022保持牢固地压在(在出口提升阀弹簧8006的辅助下)隔膜2356上,从而密封出口阀22的流体进口和流体出口,直至从泵送腔室2350流出的流体的压力迫使出口阀22打开。当达到足够压力时,流体通过出口阀22的流体出口离开,因此克服了出口阀22对隔膜2356施加的压力。当流动停止时,无源弹簧8006迫使出口阀22关闭。 
在工作冲程期间,泵致动部件弹簧8004被加载。最终,泵致动部件弹簧8004将拉动泵致动部件54远离隔膜2356。结果,在松弛冲程期间,弹簧8004将泵致动部件54和泵送板8000返回到图15C的松弛位置;加载进口提升阀弹簧8002还可以对于返回冲程提供能量。当泵 送板8000接近其松弛位置时,它接合进口提升阀9221的端盖以提起进口提升阀并且将其拉离底座,从而打开进口阀21。在返回冲程期间泵致动部件弹簧8004还被卸载。 
当达到其中进口提升阀弹簧8002处于与泵板8000相同水平的阀值距离时,将利用泵致动部件弹簧8004卸载泵板8000。在泵送腔室2350中的弹性隔膜2356将返回到它的开始位置。这形成负压力,并且当进口阀打开时,流体将通过进口阀的流体进口流动到流体出口并且朝向泵送腔室2350流动。因此,泵送机构现在将处于如图15B所示的状态中。 
当每次通过对形状记忆致动器278施加电流而致动泵时,重复关于图15B-15D描述的全部泵序列。 
在这里所谓的隔膜包括隔膜2356,其可以由能够产生必须的特性从而如在这里描述的那样发挥作用的任何弹性材料制成。另外地,隔膜材料可以包括生物相容材料,从而不会阻碍泵的操作或者降低流体的治疗价值。多种生物相容弹性材料可能是适当的,包括腈和硅树脂。然而,不同的治疗流体组分可能要求选择不同的弹性材料。 
能够根据冲程长度描述上述泵送机构还有如在这里描述的各种实施例。确定冲程长度的一种方式是利用在形状记忆致动器收缩和膨胀的一个循环期间的形状记忆致动器长度的总变化。该差异将确定泵杆行进的总距离并且因此确定了流出进口腔室2354且流到泵送腔室2350、出口腔室2352并最后流出出口腔室2352的流体总量。确定冲程长度的另一方式是泵板8000的行进距离。对于部分冲程,泵板8000将不达到它的最大行进距离。在一个实施例中,很小的冲程或者微冲程被连续地启动,以连续或者规律的方式从储液器泵送微升体积的流体到出口。例如,微冲程可以移位小于20%、10%或者1%的泵送腔室2350的容积。 
图16示出图15B示出的泵送机构实施例的变型。在图16中,使用两种不同的形状记忆致动器—较长的一个和较短的一个。图16示出图15B所示泵送机构的实施例,其中形状记忆导线278围绕滑轮286张紧并且分裂成较长的股线和较短的股线。用作负端子的公共接合点可以位于较长的和较短的股线分裂的位置处。利用两个可替代路径的任一或两个而实现的电路允许调节泵送作用力和/或冲程长度。在可替代实施例中,材料片,例如Kevlar材料,围绕滑轮从公共接合点延伸到作用力板8000,而两条分离的形状记忆导线从公共接合点延伸到其相应的支撑件。通过使用具有不同长度的两条导线,这些实施例提供如在下面描述的泵送模式和排气模式。 
关于使用形状记忆致动器变量改变冲程,对于给定长度的形状记忆致动器,冲程依赖于变量的数目:1.通电/加热的总时间;2.总电压;和3.形状记忆致动器的直径。在图17-19中示出一些可变实施例。然而,在一些实施例中,能够在保持长度、通电时间和电压的同时改变冲程。这些实施例在一个形状记忆导线上包括多个形状记忆致动器(见图19)和多个开关(见图17)。如上所讨论,也能够通过修改任何一个或者多个变量获得所需冲程长度。 
另外地,对形状记忆致动加热或者通电的定时能够改变以控制冲程。形状记忆致动器每次被加热可被视为一个脉冲。例如脉冲频率、脉冲持续时间和冲程长度的因素可以影响在一定时间输送的流体的量。 
图17-19另外地描绘具有流体泵送模式和排气模式的泵送组件的实施例。当被致动时,排气模式通过作用力施加部件施加了作用力增强的施加和/或增加位移的压缩冲程。可以基于在泵送组件中存在空气的可能性或了解的有关情况而致动排气模式。例如,可以当管线被接附到储液器时、当通过传感器或者感测设备探测到气泡时,或者当通 过传感器或者感测设备探测到流动不足时,致动排气模式。可替代地,所述两种模式可以用于对给定的泵送脉冲在移位较小和较大体积的流体之间进行选择。 
现在参考图17,概略示出利用形状记忆致动器278致动的并且具有多个操作模式的泵送组件。当泵送腔室2350被填充流体时,泵送组件以流体泵送模式操作。在流体泵送模式期间,电流在负电引线2960和正电引线2961之间流动,引起合金形状记忆致动器278电阻加热并且由此导致相位改变和动力冲程。在一个实施例中,在泵送机构灌注期间或者当怀疑在泵送腔室2350中存在气泡2950时,排气模式被致动并且电流沿着在负电引线2960和正电引线2965之间长度延伸的路径流动;结果是具有更高作用力的压缩冲程并且作用力施加部件2320的位移应该足以将空气2950从泵送腔室2350移位到泵出口2370。在可替代实施例中,正和负引线可以颠倒。 
现在参考图18,概略示出具有多个相同长度的形状记忆致动器278的可替代泵送组件。另外的致动器可以例如用于增加泵送腔室2350上的致动压力,以消除流动管线、泵送腔室或者泵送机构的其它区域中的堵塞或者气泡。另外的致动器还可以对任何泵送器件提供备用。单一形状记忆致动器可能能够产生足够的作用力以从泵送腔室消除气泡。另外地,在图18示出的实施例中,根据第二形状记忆致动器的长度,另外的回位弹簧可能是必须的。 
当储液器首先被接附到具有泵送组件的流动管线时,泵送机构(图13-14中的物件16)通常被空气填充。由于各种原因,在正常操作期间空气还能够进入泵送机构。因为空气比流体更加易于压缩,所以如果在流动管线中存在大量空气,则施加具有足以移位流体的长度的压缩冲程可能不足以产生足够的压力,以客服泵送机构单向阀的开启压力。相应地,泵送机构可能停止操作。然而,在灌注期间或者当在泵送组件中无害地存在少量空气时,可能期望迫使空气通过管线。因此,图 18示出的实施例能够用于在该情形中产生额外的作用力。 
图19概略示出具有多个形状记忆致动器的可替代泵送组件16。第一、较短的形状记忆致动器2975具有第一电引线2976和第二电引线2977。较短的致动器2975能够产生足以移位泵送腔室2350中的流体的压缩冲程;在正常流体泵送模式操作期间使用较短的形状记忆合金致动器2975。当示意排气模式或者要求较大的被泵送流体体积时,可以通过沿着置于第一电引线2973和第二电引线2972之间的致动器长度发送电流而使用第二较长的形状记忆合金致动器2970。通过形成包括在第一电引线2972和第二电引线2971之间的电路径的较短电路,较长的形状记忆合金致动器2970还可以被用作用于流体泵送模式操作的后备致动器。较短的形状记忆致动器2975还可以用于改变冲程容积以在降低的流体体积速率下提供更好的控制。图17-19的多模态致动器不限于与所示的泵构件一起使用,而是可以与这里描述的泵送机构的各种实施例的任何一个一起使用,所述实施例包括使用如在下面描述的流体泵送器件的那些以及采用如在下面描述的阀门泵的那些。因此,通过对提供所需冲程长度的长度形状记忆致动器通电/加热能够形成所需冲程长度。 
现在参考图20A和20B,每一个均示出用于接附形状记忆致动器的一个实施例。这些不同的实施例能够用于这里所述的其中采用了形状记忆致动器278的任何机构或者器件中。参考图20A和图20B,形状记忆致动器278被馈送到索环280中。索环280然后接附到部件284。虽然仅仅示出该接附模式的两个实施例,但各种其它模式被用于其它实施例中。能够使用将索环接附到一个部分或者任何固定位置的其它模式。 
现在参考图21A和21B,示出接附用于泵送机构16的形状记忆致动器278的两个示例性实施例。在这些实施例的每一个中,形状记忆致动器278被设计成围绕滑轮286转动。参考图21A,形状记忆致动 器278通过索环280接附到优选由KEVLAR材料制成的零件288。形状记忆致动器278的一个端部被示为通过定位螺钉装置289接附到部件284。现在参考图21B,形状记忆致动器的一个端部被示为通过索环280接附到部件284。 
在这里示出泵送机构的各种实施例。泵送机构可以包括进口阀、泵送致动部件和出口阀。如以上所讨论,不同类型的单向阀可以用于可替代实施例中。虽然图15A-15D示出的概略图示出了一个实施例,下面的附图示出可替代实施例。 
现在参考图22和图23,示出泵送机构一个部分的侧视图和截面。在该实施例中,泵送致动部件是泵送细长指状件32。当作用力被施加到指状件32上时,指状件32压下可移动部件并且减少流动管线的内部体积。 
图22和23中的泵送机构的部分仅仅示出泵送腔室。当与单向阀(图13中的物件21和22)相组合时,向可移动部件23施加变形作用力,迫使流体朝向出口组件(未示出)流动。如图22和23所示,指状件32是尖的以集中作用力,但是在其它实施例中,指状件32可以是扁平的或者任何其它适当形状。弹簧31用于相对于弹性部件23朝向缩退位置偏压指状件32,从而在没有施加作用力的情况下指状件32返回到缩退、非压下位置。如图23所示,马达能够被用于将作用力施加到指状件23上。然而,在其它实施例中,使用形状记忆致动器。各种类型的马达是适当的,包括电动机和压电马达。 
参考图22和23,通过防止可移动部件23响应于由指状件32施加作用力而离位,止回器33限制指状件32潜在的行进,支撑可移动部件23,并且保证降低流动管线或泵送腔室的容积。如图22所示,止回器33可以有利地具有与弹性部件23互补的形状。在各种实施例中,泵送组件16可以包括杠杆或者曲柄,该杠杆或者曲柄在一个端部上被 马达驱动,而在另一端部处压缩弹性部件23。 
现在参考图24,关于泵送组件的一个部分示出泵送致动部件的另一实施例。马达或者形状记忆致动器(未示出)向一组联接的凸起42施加旋转作用力。这些凸起42用作泵送致动部件并且顺次向可移动部件23施加作用力。相应地,作用力间歇脉冲被施加到可移动部件23。止回器33,如图所示,能够在壳体44中行进并且被弹簧46朝向弹性部件23向上偏压。 
现在参考图25,示出在柱塞筒52中具有泵送致动部件(这里是柱塞)54的作用力施加组件的实施例。马达引起柱塞54交替地退回和插入柱塞筒中。当柱塞54退回时,负压力将流体从储液器(未示出)抽吸到通道51和内腔56中。当柱塞54被插入时,与单向阀(未示出)相结合的增加的压力朝向分配组件(未示出)驱动流体。内腔56经由连接通道58连接到通道51并且柱塞筒内腔56的容积随着柱塞54的插进动作而降低,由此促动流体通过流动管线310。 
图26和27示出另一实施例,其中泵送致动部件是柱塞54。作用力施加组件和包括形状记忆致动278的线性致动器驱动柱塞54。在图26中,形状记忆导线278处于低温、膨胀状态中并且接附到第一支撑件241和柱塞接附端盖244。端盖244则顺次接附到偏压弹簧243,所述偏压弹簧顺次接附到第二支撑件242。当导线278处于膨胀状态时,偏压弹簧243处于松弛状态。图27示出形状记忆致动器278由于向导线278施加电流和同时加热而处于收缩状态中。当收缩时,作用力被施加在端盖244上,从而引起柱塞54的插入运动以及相应的泵送动作。在收缩状态中,偏压弹簧243处于高势能状态。当停止施加电场时,Nitinol导线278再次冷却和膨胀,以允许偏压弹簧243将柱塞54返回到它的缩退状态。如图21A-21B所示,形状记忆致动器278可以围绕一个或者更多滑轮缠绕。 
图28-30示出各种实施例,其中通过使用形状记忆致动器278压缩形成泵送腔室的可移动部件的泵送致动部件54实现泵送。泵送腔室由单向阀21、22界定。图28示出包括其中泵送致动部件是柱塞筒52中的柱塞54的泵送机构的实施例。该机构还包括杠杆273、支点274,以及形状记忆致动器278。形状记忆致动器278被保持在壳体298中并且在一个端部接附到导电支撑件279而在另一端部接附到杠杆273的正端子275。杠杆273则顺次在它的中心处接附到支点274并且在第二端部处接附到柱塞54。施加电流以引起电流流动通过端子275、形状记忆致动器278、以及导电支撑件279,由此引起形状记忆致动器278收缩,引起杠杆273围绕支点274枢转以及柱塞54的有效退缩。断电允许冷却形状记忆致动器278,允许它膨胀。回位弹簧276经由杠杆273作用,以将柱塞54返回到柱塞筒52中的插入位置。回位弹簧276被保持在壳体277中。O形环281防止流体从柱塞54-柱塞筒52组件泄露。柱塞54的插入和退缩引起流体沿着由两个止回阀(第一单向阀21和第二单向阀22)的定向确定的方向流动通过流动管线。可以使用任何适当的回流防止器件,它包括单向阀、止回阀、鸭嘴阀门、挡板阀和火山阀。 
图29示出具有柱塞54、柱塞筒52以及包括形状记忆致动器278的作用力施加组件的泵送机构的另一实施例。然而,不像图28示出的实施例,该实施例并不包括杠杆。形状记忆致动器278被保持在壳体298中并且在一个端部接附到导电支撑件279而在另一端部通过触点275接附到柱塞端盖244。柱塞端盖244接附到柱塞54。一旦通过触点275施加充足的电流,则形状记忆致动器278收缩。这种收缩引起在柱塞端盖244上的拉动,以实现将柱塞54插入柱塞筒52中。断电允许冷却形状记忆致动器278,由此允许它膨胀。当导线膨胀时,回位弹簧276发挥作用以将柱塞54返回到柱塞筒52中的退缩位置。回位弹簧276被保持在壳体277中。O形环281防止流体从柱塞54-柱塞筒52组件泄露。柱塞54的插入和退缩引起流体沿着通过定向第一单向阀21和第二单向阀22而确定的方向流动通过流动管线。 
现在参考图30,示出使用柱塞54和柱塞筒52的泵送器件的实施例。在该实施例中,形式为位于柱塞54中的轴内的导线的形状记忆致动器278用于在柱塞上施加作用力。形状记忆致动器278从柱塞端盖272通过柱塞54中的轴并且通过通道58延伸到支撑基部299。O形环281和282密封柱塞54、柱塞筒52和通道58。向第一引线258和第二引线257施加电流引起形状记忆致动器278加热,这导致形状记忆致动器278收缩。形状记忆致动器278的收缩使得向下作用力被施加在柱塞端盖272上,该向下作用力足以克服回位弹簧276的向上偏压力,由此驱动柱塞54进入柱塞筒52的内腔290中。形状记忆致动器278的膨胀允许回位弹簧276将柱塞54返回到退缩位置。柱塞54的插入和退缩引起流体沿着通过定向第一单向阀21和第二单向阀22而确定的方向流动通过流动管线。 
图31示出泵送机构的可替代实施例。泵送致动部件是结合储液器和泵送机构的功能的组件101。在控制器501的命令下,马达25驱动柱塞102以在储液器104中形成压力,由此迫使流体通过第一单向阀106。流体然后进入具有传感器550的容积感测组件120的弹性分配腔室122,并且流至出口组件17。可以包括可选的第二单向阀107。经由控制器501在传感器550和马达25之间的反馈控制保证所需的流体流动到患者。第一单向阀106用于当腔室被填充和扩充时防止由于容积感测组件120的分配腔室122的弹性作用力而使得流体反向流动。第二单向阀107用于防止流体从出口组件17或者患者12反向流动到分配腔室122中。在该实施例中,传感器550能够立即探测分配腔室122中的容积。 
图32-34概略示出组合阀门泵2200的截面视图。图32示出具有在致动之前位于停歇位置的收集腔室2345和泵送腔室2350的阀门泵2200;图33示出在压缩冲程期间处于致动状态中的阀门泵2200;并且图34示出在压缩冲程结束时处于致动状态中的泵。泵进口2310与例 如储液器的上游流体源流体连通并且连接到通道2360的第一端部。通道2360在第二端部处连接到收集腔室2345,该收集腔室与置于弹性泵送膜2340中的膜孔2390流体连通。收集腔室2345在第一侧上由弹性泵送膜2340并且在第二侧上由弹性泵送隔膜2330界定。在各种材料中,泵送隔膜2330可以由乳胶或者硅胶制成。膜孔2390的下游侧通向泵送腔室2350。在灌注泵期间并且在致动循环之间,流体从例如储液器的流体源行进通过泵进口2310、通道2360、收集腔室2345以及膜孔2390,然后到达泵送腔室2350。单向阀22防止流体经由泵出口2370离开泵送腔室2350,直至并且除非充足的流体压力被施加到单向阀22上以致于单向阀22打开为止。在图32中,泵送致动部件2320被示为处于停歇位置中,并且弹性泵送隔膜2330被示为处于具有最小表面区域的松弛构造中,由此最大化了收集腔室2345的容积。虽然在该实施例中,泵送致动部件被示为球形,但在其它实施例中,泵送致动部件可以是能够致动并且对弹性泵送隔膜2330施加充足作用力从而致动泵送机构的任何致动部件。 
如从图33可见,当在压缩冲程期间致动泵送致动部件2320时,泵送致动部件2320开始朝向弹性泵送膜2340的膜孔2390行进并且扩张弹性泵送隔膜2330,从而引起已经收集在收集腔室2345中的流体倒流。以后在作用力施加冲程中,如图34所示,泵送致动部件2320将以密封方式将弹性泵送隔膜2330送至膜孔2390。为了辅助密封,泵送致动部件2320可以具有与膜孔2390的形状互补的形状。例如,泵送致动部件2320可以是球形的或者锥形的并且膜孔2390可以是柱形通孔。在作用力施加冲程的这个阶段,从泵送腔室2350的倒流将被抑制。泵送致动部件2320继续行进将使弹性泵送膜2340变形并且增加泵送腔室2350中的压力,同时继续密封膜孔2390以防止从泵送腔室2350倒流。当泵送腔室2350中的压力对单向阀22施加充足流体压力时,流体将从泵送腔室2350流动通过泵出口2370。在返回冲程期间,泵送致动部件2320、弹性泵送隔膜2330和弹性泵送膜2340返回到图32示出的松弛位置。在返回冲程期间,泵送腔室2350和收集腔室2345的 内部压力将下降,这将通过诱导流体从流体源流动通过泵进口2310和通道2360而促使再次对阀门泵2200进行填充。 
现在参考图35,示出弹性泵送膜2340的一个实施例的概略截面视图。膜片本体2515可以由例如硅胶的弹性材料构造。也可以包括膜片弹簧2510以向柔性或者已经是弹性的本体2515赋予弹性。膜片弹簧2510可以嵌入弹性泵送膜2340中或者靠近弹性泵送膜2340而布置。在图36中示出膜片弹簧2510的一个实施例的实例。可以使用包括柔顺材料的膜片本体2515以及包括弹性材料的膜片弹簧2510的组合;其结果是泵送膜2340当接触被泵送致动部件(未示出,见图32—34)变形的弹性泵送隔膜2330时将呈现高度密封性并且还具有高度弹性。阀座2517可以围绕膜孔2390定位。阀座2517可以用作用于弹性泵送隔膜2330的变形部分的接收器。作用力施加部件2320可以使泵送隔膜2330变形,从而引起隔膜2330变形并且以密封方式接触阀座2517。如果施加足够的作用力,则阀座可以弹性变形以保证彻底密封从而防止流体倒流。通常能够不同地选择阀座2517的截面高度与截面宽度的比率使其与流动环境相匹配。 
现在参考图36,示出用于图35的泵送膜2340中的膜片弹簧2510的实例。外部环面2520和内部环面2540通过至少三个弹性臂2530连接。内部环面2540的中心具有弹簧孔2550,所述弹簧孔可以对准如图35所示的泵送膜2340的膜孔2390。 
现在参考图37,示出了一概略图,该概略图与包括泵送致动部件2320、致动器和杠杆273的作用力施加组件相组合地显示了在前面示于图32-34中的阀门泵2200的截面视图。当被例如形状记忆致动器278的致动器激励时,杠杆273围绕支点274枢转以启动压缩冲程。锤体2630从杠杆273突出。在压缩冲程期间,锤体2630接触圆化的泵送致动部件2320,引起泵送致动部件在支撑结构2660的空隙中行进,并且将泵送致动部件2320推压到弹性泵送隔膜2330,直至泵送致动部件 2320以密封方式保持到位于弹性泵送膜2340中的膜孔2390。当杠杆273继续行进时,泵送致动部件2320引起泵送膜2340变形。当足够的流体压力被施加到单向阀22上时,单向阀22打开。这允许流体从泵送腔室2350流动通过泵出口2370。当形状记忆致动器278冷却时,泵送膜2340的弹性和泵送隔膜2330的弹性将引起杠杆273返回到由杠杆止挡件2650和杠杆制动件2640确定的开始位置。可替代地,回位弹簧(未示出)可以用于将杠杆273返回到开始位置。虽然被示为球体,但是作用力施加部件2320可以可替代地是活塞、杠杆273的凸起或者其它适当形式。 
图38概略示出使用弹性柱形屈曲2670的阀门泵的实施例的截面视图。在一个实施例中,弹性柱形屈曲由橡胶制成,但是在其它实施例中,它能够由任何弹性材料制成。柱形屈曲2670具有中央通路2675,以及抵靠壳体2673密封布置的多个弹性径向翼片2672。进入泵进口2310的流体经过通道2360并且被收集在单向阀22上游的区域中:收集腔室2345、柱形屈曲2670的中央通路2675,以及泵送腔室2350。泵送腔室通过中央通路2675与收集腔室2345流体连通的方式地联接。在泵送机构压缩冲程期间,泵送致动部件2320向弹性泵送隔膜2330施加作用力,使其变形,直至弹性泵送隔膜2330被密封地保持到柱形屈曲2670的阀座2680;由此阻止从收集腔室2345到泵进口2310的倒流。泵送致动部件2320的继续行进引起柱形屈曲2670变形;泵送腔室2350中的压力增加直至足以打开单向阀22时为止。流体然后能够流过泵出口2370。 
在图38中泵送致动部件2320被示为球形。然而在其它实施例中,泵送致动部件2320可以是能够如上所述发挥作用的任何形状。 
现在参考图39,示出采用弹性部分2680和刚性柱形支撑件2690的柱形屈曲2670(示于图38中)的可替代实施例。类似于图38的柱形屈曲2680,柱形屈曲2670的弹性部分包括当通过泵送致动部件2320 施加作用力时密封中央通路2675的阀座2680。因此,柱形屈曲2670的弹性部分2680变形以向泵送腔室2350传递压力。 
图40-44概略示出在各种致动状态中阀门泵的可替代实施例的截面视图。图40-44的阀门泵2200具有弹性膜片弹簧6100和弹性密封隔膜6120,它们一起地发挥类似于图32-34所示阀门泵2200的弹性泵送膜2340功能的功能。图40示出处于停歇状态的阀门泵2200。在停歇状态中,流体可以从进口2360流动到收集腔室2345的上部2346,通过膜片弹簧6100中的孔隙6110并且进入收集腔室2345的下部2347中。流体然后可以继续通过密封隔膜6120中的一个或者多个开口6130并且进入泵送腔室2350。在低压力状态下,通过单向阀22阻止流体进一步流动。弹簧膜片6100和密封隔膜6120均可以由弹性、生物相容材料构造。弹簧膜片6100可以具有比密封隔膜6120更高的弹性。例如,弹簧膜片6100可以是柔性生物惰性塑料圆片而密封隔膜6120可以是硅树脂或者氟硅氧烷弹性体。 
图41和42示出处于两个中间、局部致动状态中的阀门泵2200。泵送致动部件2320使泵送隔膜2330变形并且迫使其通过收集腔室2345且压靠弹簧膜片6100,弹簧膜片则顺次变形并且被迫压靠密封隔膜6120。在压缩冲程中的这一点,通过弹簧膜片6100的孔隙6110,或者通过密封隔膜6120中的开口6130,或者通过这两者的倒流均被抑制。密封隔膜开口6130相对于弹簧孔6100的偏移允许在弹簧膜片6100和密封隔膜6120之间形成密封。在一些实施例中,该密封可以利用在填充腔室弹性泵送隔膜2330和弹簧膜片6100之间的备用密封予以补充(例如,图43-44的实施例缺少这种备用密封)。围绕弹簧膜孔6110的周向凸脊(未示出)可以用作阀座以加强所述密封。 
现在参考图42,泵送致动部件2320的继续行进引起泵送隔膜2330、弹簧膜片6100和密封隔膜6120进一步变形。结果,泵送腔室2350中的流体被压缩直至流体压力迫使单向阀22打开;进一步压缩引 起流体通过出口2370流出。 
在图43中概略示出图40-42的阀门泵2200的可替代实施例。在该实施例中,泵送致动部件2320穿越弹性泵送隔膜2330。泵送隔膜2330在沿着泵送致动部件2320长度的中点处被密封地接附到泵送致动部件2320的周边。当被致动时,膜片弹簧孔6110仅被密封隔膜6120密封以防止回流;弹性泵送隔膜2330将不接触孔隙6110。在图44中示出图40所示器件的可替代实施例。 
现在参考图45,示出组合阀门泵2200的可替代实施例的截面视图。形状记忆致动器278致动压缩冲程,以引起弹性泵叶片2710围绕支点274抬起(lever),这引起弹性泵送隔膜2330变形。弹性泵叶片2710和弹性泵送隔膜2330向具有浅区域2730和较深区域2740的梯级泵送腔室2720中的流体施加压力。在压缩冲程早期中,泵叶片2710引起弹性泵送隔膜2330阻塞将泵进口2310连接到梯级泵送腔室2720的通道2360。当压缩冲程继续时,作用力被施加到梯级泵送腔室2720中的流体,直至梯级泵送腔室2720中的流体压力足够高以打开单向阀22。流体然后离开泵出口2370。泵叶片2710可以全部或者部分由例如橡胶的弹性材料构造。在一些实施例中,弹性材料包括非弹性方栓(spline)。可替代地,在一些实施例中,通过弹性区域2750施加弹性,因此,弹性区域2750是这些实施例中的泵叶片2710的仅有的弹性部分。在这些实施例中,弹性区域2750接触梯级泵送腔室2720的底部。泵叶片2710的弹性允许在泵送叶片2710接触浅区域2730的基部2780之后压缩冲程继续。回位弹簧(未示出)在返回冲程期间将泵叶片2710返回到开始位置。 
现在参考图46,示出泵送机构的可替代实施例的截面视图。该实施例包括弹性泵叶片2710。弹性泵叶片2710包括向泵叶片2710提供弹性的弹性区域2830。弹性区域2830将泵送致动部件2820结合到泵叶片2810。当与阀门泵(未示出)一起使用时,图42的弹性泵叶片 2710将堵塞进口通道(未示出,在图45中示为2360)并且然后在柔性区域2830处弯曲以允许作用力施加部件2820向梯级泵送腔室(未示出,在图45中示为2720)中的流体施加进一步的压力。作用力施加部件2820可以全部由例如橡胶的弹性材料构造。然而,在可替代实施例中,仅仅接触泵送腔室(未示出)底部的区域由弹性材料制成。弹性泵叶片2710在返回冲程期间将返回到它的松弛形态。 
现在参考图47,示出泵送机构的另一实施例的截面视图。所述泵送机构被示为其中杠杆处于致动中间阶段,其中进口阀2941被关闭。泵送机构包括流动管线2930、在该实施例中为隔膜的可移动部件2330、进口阀2941提升阀2940、泵送致动部件2942、泵送腔室2350以及出口阀22。进口阀2941和泵送致动部件2942每一个均由被回位弹簧276围绕并且连接到杠杆273的形状记忆致动器278致动。杠杆273致动进口阀2941和泵送致动部件2942。杠杆273包括接附到铰接于支点274且终止于阀门致动锤体2946的杠杆273的细长弹簧部件2910。弹簧部件2910可以是弯曲的。弹簧部件2910远离杠杆273并且朝向进口阀2941地偏压阀门致动锤体2946的位置。杠杆273具有未被接附到弹簧部件2910的泵致动锤体2948,并且邻近泵送致动部件2942定位。 
电流引起形状记忆致动器278收缩并且杠杆273围绕支点274枢转。所述枢转将阀门致动锤体2946置于迫使进口阀2941关闭的位置中。当形状记忆致动器278继续收缩时,杠杆273继续枢转并且泵致动锤体2948将泵致动部件2942压向泵送腔室2350,即使当进一步压缩细长弹簧部件2910时。当实现足够压力时,流体压力打开出口阀22,并且流体通过该阀门流出。 
在松弛冲程期间,回位弹簧276卸载并且将杠杆273返回到开始位置,释放泵送致动部件2942。进口阀2941打开。泵送腔室2350的弹性引起泵送腔室2350再次填充。 
现在参考图48和49,它们概略示出其中泵送机构采用曲拐7200并且将阀门泵2200与偏流阀门相结合的实施例的截面。曲拐7200将通过线性形状记忆致动器278产生的作用力转变成横向泵送作用力。图48示出所述机构处于停歇或者再次填充模式中,并且图49示出所述机构处于致动状态中。致动器278收缩引起曲拐7200围绕轴7210旋转并且压靠在作用力施加部件2320上。这驱动弹性隔膜7220密封于弹性泵送膜2340并且从泵送腔室2350朝向分配腔室122促动流体。回位弹簧276与回位弹簧支撑件7221协作以释放泵送作用力,引起泵送腔室2350膨胀并且从储液器20抽吸流体。仍然参考图48和49,还示出偏流阀门4000,它具有阀门弹簧4010、提升阀或者柱塞4020。 
在上述泵送机构的一些实施例中,下面的阀门操作说明的一个或者多个方面是相关的。现在参考图50,示出被关闭的偏流阀门4000的实例。阀门弹簧4010在提升阀4020上施加作用力以密封地将阀门隔膜4060压向围绕阀门出口4040的终端孔隙的阀座4070。阀座4070可以包括周向升高部分以改进密封性。如在下面参考图54-55所解释,通过弹性分配组件的作用形成的背压应当不足以引起通过偏流阀门4000的倒流。如图51所示,当泵送组件被致动时,应该产生足够压力以使得隔膜4060和提升阀4020从阀座4070脱离,由此允许流体从阀门进口4030流动,通过进口腔室4050并且流到阀门出口4040。图52-53示出具有不带周向升高部分的阀座4070的可替代阀门。 
现在参考图54和55,示出对示例性偏流阀门如何区分向前流动和倒流的示意。图54概略代表了处于关闭位置中的阀门。出口4040中的背压对柔性阀门隔膜4060的邻近阀座4070的较小区域施加作用力并且因此不能够将提升阀4020移出。现在参考图55,该图概略示出了在泵送致动部件致动期间的阀门。被泵送的流体的压力在隔膜4060的大于邻近于阀座的区域的区域上施加作用力。结果,进口压力具有更大的机械优点以使得提升阀4020脱离阀座,并且响应于泵送致动部 件的动作使得向前流动随即发生。因此,用于移位提升阀4020所需的临界压力在进口中比在出口中更低。相应地,与流体进口和流体出口相关联的作用力施加区域的弹簧偏压作用力和尺寸可以被选择从而流动基本沿着向前方向。 
现在参考图56,示出可调节偏流阀门4130的截面视图,所述阀门以类似于图50中的偏流阀门的原理操作,但是允许调节打开阀门所必须的压力,即“开启压力”(在一些实施例中,可以从0.2到20磅每平方英寸或者“psi”)。通过旋转弹簧张紧螺钉4090而调节开启压力,所述旋转改变凹部4080的容积以压缩或者解压阀门弹簧4010,由此改变弹簧4010偏压作用力。阀门弹簧4010朝向阀门隔膜4060偏压柱塞4100以将其促动到阀座。柱塞4100发挥类似于偏流阀门(在图50-53中分别地示为4020和4000)的固定作用力提升阀的作用力施加功能。压缩阀门弹簧4010将增加它的偏压力,由此增加开启压力。相反,解压弹簧4010将降低它的偏压力以及相关开启压力。阀门弹簧4010围绕柱塞4100的轴共轴地定位并且在柱塞4100上施加它的偏压作用力。在一些实施例中,柱塞4100的轴可以短于阀门弹簧4010的以及凹部4080的长度,以允许其响应于在流体进口4030中增加的流体压力而自由移位。柱塞4100可以具有根据需要发挥功能所必须的任何尺寸。如在图50-53的实施例中,润湿部分可以位于一次性部分2610中并且作用力施加构件(例如,柱塞和弹簧)可以位于可再用部分2620中。操作原理也是类似的;在流体进口4030中相对于出口4040的更大的机械优点更加利于向前流动而非倒流。可替代地,柱塞4100可以被提升阀(在图50-55中被示为4020)替代。在一些实施例中,可能期望消除升高的阀座;在这些实施例中,柱塞可以是球形的或者是能够集中作用力的另一形状。 
偏流阀门4000基本上减轻或者防止从分配腔室122进入泵送腔室2350的倒流。如在图50-56中,阀门弹簧4010偏压提升阀或者柱塞4040以将隔膜7220压向阀座4070,其方式使得为通过线310的向前流动提 供机械优点。通过发挥泵送隔膜2330和阀门隔膜的功能,隔膜7220允许流动管线310、泵送腔室2350和泵送膜2340位于一个构件中(例如,一次性部分2610)并且泵送机构的其余部分位于第二、可移除构件中(例如,可再用部分2620)。通过在可再用部分2620中安置更加耐用的和昂贵的构件,可以实现经济性和方便性。 
在以上各种实施例中描述的泵送机构能够用于各种器件以泵送流体。作为一个示例性实施例,在图59A-59E、图60A-60D和图60A-60C中描述的泵送机构将被描述为集成于流体泵送器件中。 
参考图57和58,示出用于流体示意的可替代方式。它们是两个概略图,其中储液器20和泵送组件16被联接到分配组件120。在图57示出的实施例中,储液器和泵送组件被串联地联接到分配组件120。在图58示出的实施例中,分流线150从泵送组件16的输出联接并返回到储液器20。因为泵送组件16的大部分流体输出经由分流线150被返回到储液器20,所以泵送组件16能够包括可以不发挥图57所示实施例所需功能的各种泵送机构16。因此,在其中采用大容积泵送机构的一些实施例中,分流线150能够向大容积泵送机构赋予小容积功能性。单向阀21和22以相同方向定向并且被包括进来以防止不希望发生的回流。 
现在参考图59,示出流体泵送器件的一个实施例的流体概略图。在该实施例中,流体位于连接到流动管线310的储液器20中。流动管线310与泵送机构16连通,被隔膜2356分离。流体通过限流器340被泵送到输液器件或者套管5010以便输送给患者。应该理解输液器件或者套管5010不是器件本身的一个部分,而是接附到患者以便输送流体。在下面更加详细地描述系统实施例并且它们包括输液器件或者套管5010。 
现在参考图59B,示出图59A所示概略图的可替代实施例。在图 59A所示实施例中,流体被泵送通过限流器340然后通过套管5010。然而,在图59B中,流体不被泵送通过限流器;而是,流体被泵送通过具有相同阻抗的套管5010。 
在图59A和59B中,在一个实施例中,利用泵冲程粗略计算被泵送到患者的流体体积。冲程长度将提供对泵送到患者的体积的粗略估计。 
现在参考图59C,示出流体泵送器件的一个实施例的流体概略图。在该实施例中,流体位于通过隔片6270连接到流动管线310的储液器20中。流动管线310与泵送机构16连通,通过隔膜2356分离。流体被泵送到可变容积输送腔室122并且然后通过限流器340到达套管5010以便输送给患者。 
使用包括如上所述的声学体积感测(AVS)组件、可变容积输送腔室122和分配弹簧130的分配组件120确定所输送的流体体积。类似于泵送机构,隔膜2356形成可变容积分配腔室122。隔膜由与泵送机构16(在上面详细描述的)中的隔膜2356相同的材料(或者,在一些实施例中,不同材料)制成。AVS组件在上面被更加详细地描述。 
现在参考图59D,示出图59C所示实施例的可替代实施例,在该实施例中,在可变容积输送腔室122和套管5010之间不存在限流器。现在参考图59E,示出图59C所示实施例的可替代实施例,该实施例带有可替代泵送机构16。 
现在参考图59A-59E,储液器20能够是任何流体源,包括但不限于注射器、可塌陷储液器药袋、玻璃瓶,玻璃药瓶(glass vile)或者能够安全地容纳将被输送的流体的任何其它容器。隔片6270是在流动管线310和储液器20之间的连接点。在下面更加详细地描述隔片6270和储液器20的各种实施例。 
图59A-59E示出的流体输送器件实施例能够用于输送任何类型的流体。另外地,该实施例能够作为一个、两个或者三个独立的配合部分而被使用。现在参考图60A-60D,关于图59A-59D描述的相同实施例被示为分离成多个配合部分。部分X包括可移动部分而部分Y包括流动管线310和隔膜2356。在这种设计的一些实施例中,部分Y是一次性部分而部分X是非一次性部分。部分X并不直接接触流体,仅仅部分Y是具有润湿区域的部分。在以上实施例中,储液器20能够具有任何尺寸,并且或者被集成到一次性部件中或者是独立的一次性部件。在任一实施例中,储液器20能够被再次填充。在其中储液器20被集成到一次性部分Y中的实施例中,储液器20能够被制造成填充有流体,或者由患者或用户通过隔片6270使用注射器填充储液器20。在其中储液器20是独立的配合部件的实施例中,储液器20能够被制造成填充有流体,或者,患者或用户通过作为储液器加载器件(未示出,在下面更加详细地描述)的一个部分的隔片6270使用注射器(未示出)填充储液器20或者通过隔片6270手动地使用注射器填充储液器20。在下面描述有关填充储液器20的过程的进一步的细节。 
虽然已经关于图59A-59E和图60A-60D描述了各种实施例,但是泵送机构可以是在这里作为实施例描述的任何泵送机构或者是具有类似功能和特征的可替代实施例。例如,现在参考图61A,与图59A所示类似的实施例被示为具有包括泵送机构16的代表性模块。这是用以示出,在这里描述的或者类似地发挥作用的任何泵送机构16能够用于所述流体泵送器件中。类似地,图61B和图61C是分别包括图59B和图59C的实施例的系统的代表。 
在患者可以使用的器件中能够实现上述流体泵送器件的概略。存在多个实施例。所述器件可以是独立的器件或者集成到另一器件中。所述器件可以具有任何尺寸或者形状。所述器件可以是便携式或者非便携式的。术语“便携式”意指患者能够在缚于身体的衣袋区域内或者 以其它方式携带所述器件。术语“非便携式”意指所述器件位于保健机构中或者家中,除此之外,患者不能将所述器件带至他们所能移动的几乎任何位置处。本说明的其余部分将关注作为示例性实施例的便携式器件。 
关于便携式器件,所述器件能够被患者配戴或者被患者携带。在其中患者配戴所述器件的实施例中,为了本说明的目的,将其称作“贴片泵”。当患者携带所述器件时,为了本说明的目的,将其称作“便携式泵”。 
下面的说明能够适用于关于贴片泵实施例或者便携式泵实施例的各种实施例。在各种实施例中,该器件包括壳体、泵送机构、流动管线、可移动部件、储液器、电源和微处理器。在各种实施例中,分配组件,例如在一些实施例中包括AVS组件的容积感测器件被包括在所述器件中。而且,实施例还能够包括限流器,但是这在下面的图中未予描绘,因为流动管线被示为是均一的,以简化示意。为了该说明的目的,当包括分配组件时,示例性实施例将包括AVS组件。虽然AVS组件是优选实施例,但在其它实施例中,能够使用其它类型的容积感测器件。然而,在一些实施例中,不使用容积感测器件,而是,储液器自身将确定所输送的流体的体积,或者适于泵冲程来粗略地确定所输送的体积量。应该理解这里示出的概略器件旨在示意所述器件中的一些改变。由这些概略图代表的实施例每一个均还可包括传感器壳体、振动马达、天线、无线电装置或者关于图70-70D描述的其它构件。因此,这些描绘并非旨在限制所述构件而是用以示意各种构件如何能够在器件中相互关联。 
现在参考图62A,示出独立器件10的概略图。壳体10能够具有任何形状或者尺寸并且适应于预期用途。例如,当所述器件被用作贴片时,所述器件将足够紧凑以使本身能够被配戴。当所述器件被用作便携式泵时,所述器件将足够紧凑从而被相应地使用。在一些实施例 中,壳体由塑料制成,并且在一些实施例中,塑料是任何注射模制流体相容的塑料,例如聚碳酸酯。在其它实施例中,壳体由铝或钛和塑料或者任何其它材料的组合制成,在一些实施例中所述材料是轻质的并且耐用的。另外的材料可以包括但不限于橡胶、钢、钛及其合金。如图62A所示,器件10能够具有所需的任何尺寸或者所需形状。 
图62A—69B是示出代表性实施例的概略图。准确设计依赖于很多因素,包括但不限于器件尺寸、功率限制和预期用途。因此,图62A—69B旨在描述器件的各种特征和可能的组合,然而,本领域普通技术人员能够易于设计和实施实际器件。作为实例,在下面描述并且示出器件实施例。然而,这些实施例并非旨在限制,而是旨在示例。 
现在参考图62B,关于贴片器件,在一些实施例中,壳体10包括插入区域视窗342。该视窗允许在患者身上具有一部位,在该部位处输液器件或者套管(未示出)被插入并被看到。这里示出器件10的管罩5030区域。视窗342由能够是透明的任何材料制成,包括但不限于塑料。虽然视窗342被示为在一个具有具体形状的器件上处于一个具体位置中,但视窗342能够在任何壳体实施例中被集成在所需的任何位置中。 
现在参考图63A,示出器件10。储液器20被示为连接到流动管线310,流动管线然后连接到泵送机构16。分配组件120被示为连接到流动管线310。泵送机构16和分配组件120通过隔膜2356而与流动管线310分离。管罩5030位于体积测量器件的下游。形状记忆致动器278被示为连接到泵送机构16。印刷电路板13上的微处理器以及电源或者蓄电池15被包括在内。也能够在分配组件120和管罩5030之间实现如上所述的流阻。 
现在参考图63B,示出如图63A所示的类似的器件10,只是在该实施例中,不包括分配组件。在该实施例中,所输送的流体体积将依 赖于泵冲程(数目和长度)、储液器20(容积和时间)、两者、或者在前面关于监视所输送流体体积所述的任何其它方法。 
现在参考图63C,示出如图63B所示的类似的器件10,只是器件10包括分配腔室122和传感器壳体5022。 
现在参考图64A,示出贴片泵器件10的一个实施例。该实施例基于图63A示出的器件10的实施例。在该实施例中,贴片泵器件10被划分成两个部分:顶部X和基部Y。顶部X含有泵送机构16、分配组件120(它是可选的,但是作为示例性实施例示出)、电源15和微处理器以及印刷电路板13。它们是非润湿元件,即,它们并不直接接触流体。基部Y含有流动管线310和隔膜2356。当储液器20被内置于所述器件中时,储液器也被包含在基部Y上。然而,在其中储液器20是独立的配合部件的实施例中,当完全组装时储液器20连接到流动管线(见图66A-66D以及参考它们的说明),而没有被内置于所述器件中。 
贴片泵器件还包括管罩5030。这是套管线5031所在的区域。流动管线310的一部分,套管线5031允许套管(或者其它输液器件)接收流体并且向患者(未示出)输送流体。 
现在参考图65A,在一些实施例中,套管5010通过壳体5030被直接插入患者体内。套管5010连接到将套管线5031连接到套管5010的隔片(未示出)。 
现在参考图65B,在其它实施例中,使用插入套件(包括套管和管线,在图65B中未示出,在图64B中示为物件5033和5010);因此,插入套件的管线5033将在一个端部上连接到套管线5030并且在管线的相对端部上连接到套管(未示出)。 
再次参考图64A,在使用中,内部含有流体的储液器20(如上所述,被模制到基部Y中或者是独立的且接附到基部Y)被连接到流动管线310。印刷电路板13上的微处理器发送信号,以致动泵送机构16并且通过施加到形状记忆致动器278的电流启动冲程。流体从储液器20在流动管线310中流动到分配组件120或者AVS组件。这里,确定流体在AVS腔室中的准确体积并且迫使流体流出AVS腔室、流至套管线5031和管罩5030。 
现在参考图64B,图64A所示器件被示为连接到插入套件,即,管线5033和套管5010。在图64C中,器件的基部Y被示为使用粘结剂贴片或者垫片3100而接附到患者12的身体。应该指出,在该实施例中,元件3100能够是垫片或者是贴片。然而,如在下面更加详细描述,物件3100被称为贴片,并且物件3220被称为垫片。仅仅为了简明的目的而使用物件3100;然而,在一些实施例中,使用垫片,因此在那些情形中物件3220将是适当的。 
通过管罩5030插入从而利用套管隔片5060配合到套管线5031的套管5010被插入患者12体内。然而,如在上面关于图2B所示和所描述的,基部Y能够通过包括管线5033和套管5010的插入套件而流体地接附到患者。在图64B和64C中,基部Y能够在插入套管5010之前或者之后被附着到患者。再次参考图2C,套管5010在一旦插入患者12体内之后则将直接从器件接收流体而不用输液设定管线(图64B所示)。基部Y在插入套管5010之前或者之后利用粘结剂贴片3100附着到患者12。现在参考图64D,在套管5010已被插入患者12体内之后,器件10的顶部X进而被接附到器件10的基部Y。 
如在下面所描述,粘结剂贴片能够具有很多实施例,并且在一些情形中,所述贴片被置于器件的顶部上。因此,在这些实施例中示出的贴片仅仅是一个实施例。如上所述,垫片,如果使用的话,将被置于与图64A-64D中的贴片相同的位置中。 
现在参考图66A-66D,在该实施例中,储液器20被示为分离的部件。如图66A所示,基部Y包括具有隔片针6272的储液器空腔2645。如图66B所示,储液器20首先被置于顶部储液器空腔2640中。此时,储液器20不被接附到器件。现在,参考图66C,当顶部X被置于基部Y之上时,储液器20被夹在基部储液器空腔2645中。如图66D所示,通过将顶部接附到基部Y而形成的作用力将隔片针6272推入将储液器20的隔片6270中,该隔片6270将储液器20连接到基部Y的流动管线310。 
现在参考图67A-F,示出图64A、64C和66A-66D所示实施例的可替代实施例。在这些可替代实施例中,除了管罩5030,基部Y包括传感器壳体5022。现在参考图69A-69B,传感器壳体5022和管罩5030均包括到达基部Y下侧的出口,在图69A中分别地示为5022和5030。图69B描绘图69A所示的实施例,其中尖锐物通过壳体突出。传感器壳体容纳传感器。在一些实施例中,传感器是分析物传感器。所感测的分析物包括血液葡萄糖,但是在其它实施例中,该分析物传感器能够是所需的任何类型的分析物传感器。 
现在参考图67B,基部Y被示为位于患者12的身体上。传感器5020被示为已通过基部Y传感器壳体5022被插入患者12体内。现在参考图67C,在一些实施例中,套管5010和传感器5020同时地通过它们相应的壳体(5030和5022)被插入并且进入患者12体内。下面参考图67D,基部Y被示为利用套管5010和通过基部Y接附到患者12的传感器5020两者而接附到患者。 
现在参考图67E,基部Y被示为接附到患者12和通过管罩5030插入的套管5010。在该实施例中,传感器壳体5022被示为不具有传感器。然而,传感器5020被示为在另一位置中插入患者12体内。因此,不要求传感器5020通过基部Y被插入,但是,下面所描述的与监视血 液葡萄糖和通过套管泵送胰岛素有关的实施例能够以此方式实施。另外地,能够以此方式实施与响应于或者涉及分析物水平的流体给药有关的其它实施例。 
现在参考图67F,通过基部Y而具有传感器5020和套管5010的器件10被示为在其上具有顶部X。再次,在图66A-66D示出的实施例中,一旦顶部X被置于基部Y上,则储液器20被流体连接到流动管线310。 
现在参考图68,示出器件10的便携式泵实施例的一个实施例。在该器件10中,包括套管5010和管线5033的插入套件必须将器件10中的流动管线连接到患者12。因此,套管5010在该实施例中没有通过便携式泵器件10而直接连接到患者12。另外地,虽然该实施例能够发挥如在下面关于分析物传感器和流体泵描述的功能,但是传感器5020将类似于图5F所示传感器5020的实施例而位于便携式泵器件10的外部。 
现在参考图70-70D,被描述的贴片泵和便携式泵实施例均另外地含有分配组件的各种构件(在可应用实施例中),并且对于包括AVS组件的实施例,分配组件的各种构件包括至少一个麦克风、温度传感器、至少一个扬声器、可变容积分配腔室、可变容积腔室、端口和基准腔室。在一些实施例中,该器件含有下面的器件中的一个或者多个:振动器马达(并且,在那些实施例中,马达驱动器)、天线、无线电装置、皮肤温度传感器、推注按钮,并且在一些实施例中,一个或者多个另外的按钮。在一些实施例中,所述天线是四分之一波长跟踪天线。在其它实施例中天线可以是半波长或者四分之一波长跟踪、偶极、单极或者回路天线。所述无线电装置,在一些实施例中是2.4GHz无线电装置,但是在其它实施例中,所述无线电装置是400MHz无线电装置。在另外的实施例中,所述无线电装置能够是任何频率的无线电装置。因此,在一些实施例中,所述器件包括强度足以与在距所述器件 几英尺距离内的接收器通信的无线电装置。在一些实施例中,所述器件包括第二无线电装置。在一些实施例中,所述第二无线电装置可以是特殊的远程无线电装置,例如433或者900MHz无线电装置,或者,在一些实施例中,具有在ISM频带或者其它频带中的任何频率,在图70-70D中未示出,所述器件在一些实施例中含有屏幕和/或用户接口。 
下面对这些构件及其各种实施例的说明能够适用于两种器件类型,并且进而能够适用于关于每一种器件类型描述的各种实施例。现在参考图67F,仅仅为了示意目的,套管5010和传感器5020均已被插入器件10中。而且,参考图70-70D,各种构件(其中一些并非必须被包括在所有的实施例中)被示为概略代表那些构件的电连接。图70-70D因此代表可被包括在所述器件中的各种元件。根据尺寸要求、功率限制、用途和偏好以及其它变量,这些元件能够被混合和匹配。图70示出图70A-70D的关系。 
所述器件含有至少一个微处理器271。该微处理器能够是至少能够处理使得所述器件运行所必须的各种电连接的任何速度的微处理器。在一些实施例中,所述器件含有多于一个的微处理器,如图70A-70B所示,所述器件被示为具有两个微处理器271。 
微处理器271(或者在一些实施例中,多个微处理器)连接到主印刷电路板(在下文中,“PCB”指的是术语“印刷电路板”)13。在一些实施例中是蓄电池15的电源连接到主PCB13。在一个实施例中,蓄电池15是能够被再充电的锂聚合物蓄电池。在其它实施例中,所述蓄电池可以是任何类型的可更换的蓄电池或者可充电的蓄电池。 
在一些实施例中,所述器件包括连接到主PCB13的无线电装置370。无线电装置370使用天线3580与远程控制器3470通信。在器件10和远程控制器3470之间的通信因此是无线的。 
在一些实施例中,所述器件含有振动马达3210。振动马达3210连接到主PCB13马达驱动器3211上的马达驱动器3211。 
一些实施例包括推注按钮3213。推注按钮3213通过用户向可由橡胶或者任何其它适当材料制成的按钮结构3213施加作用力而发挥作用。该作用力致动接附到主PCB13上的推注按钮开关3214的推注按钮致动。开关3214致动单一推注,其将示意具体的预定体积的流体将被输送给患者。在用户按压推注按钮3213之后,在一些实施例中,器件10将产生警报(例如,致动振动马达3210和/或向远程控制器发送信号)以向用户示意按钮3213被按压。用户然后需要例如,通过压下按钮3213而确认推注应被输送。在另外的实施例中,远程控制器3470询问用户以确认推注应该被输送。 
类似的询问/响应序列可以用于各种实施例以测试并且报告患者响应性。例如,所述器件可以被配置为通过产生警报(例如,听觉和/或触觉警报)并且等待患者响应(例如,致动按钮3213)而测试患者响应性。可以在不同时间(例如,每五分钟)或者当探测到例如经由分析物传感器监视的异常分析物水平或者经由温度传感器监视的异常身体温度的状态时执行这种测试。如果患者未在预定时间内提供适当响应,则可再用部分可以向远程控制器或者看管者发送警报。对于由于器件故障或者其它原因而可能变得失去意识或者丧失能力的患者而言,这种测试和报告可能是特别有价值的。 
主PCB13上的NITINOL电路(参考形状记忆致动器,在一些实施例中,是NITINOL股线)278向NITINOL连接器提供电流。如图67F和图70A所示,该器件能够包括两个NITINOL连接器278(和两个NITINOL股线)。然而,如上所述,在一些实施例中,该器件包括一个NITINOL连接器(和一个NITINOL股线)。 
在一些实施例中,该器件包括图70B所示的温度传感器3216。温 度传感器3216位于基部Y的下侧上并且感测患者的皮肤温度。皮肤温度传感器3216连接到由3217代表的信号调节器。如图70B所示,信号调节3217被表示为一个方框,然而该器件根据需要包括多个信号调节器,每一个均过滤不同信号。下面,AVS温度传感器132、AVS麦克风133和分析物传感器5020均被连接到在作为3217的一个方框中代表的信号调节器。 
AVS扬声器134连接到主PCB13上的扬声器驱动器135。AVS扬声器134在一个实施例中是听力辅助扬声器。然而,在其它实施例中,扬声器134(含有音圈的扬声器、带有电磁线圈的磁体)是压电扬声器(示于图50,代表所述器件的一个实施例)。 
仍然参考图70-70D,在一些实施例中,天线3580具有专用PCB3581,该专用PCB然后连接到主PCB13。而且,在一些实施例中,AVS麦克风133每一个均具有连接到主PCB13的专用PCB1332、1333。可以使用传统方法,例如柔性电路或者导线,将各种PCB连接到主PCB13。 
参考图67F,为说明目的,作为示例性实施例示出器件10。然而,各个部分的布局能够改变,并且在下面示出很多实施例。然而,另外的可替代实施例没有被示出,而是能够基于尺寸、功率和用途加以确定。 
根据可替代实施例,一次性部分2610可以包括储液器20并且可选地包括蓄电池。储液器20可以与一次性部分形成一体或者以其他方式联接到一次性部分。蓄电池可以是用于所述器件的主要的或者唯一的电源或者可以是后备电源,并且可以用于向可再用部分和/或一次性部分上的电子器件提供电力。储液器20和蓄电池一般均要求定期更换,所以将这两个构件包括在一次性部分2610中可以向用户提供同时进行更换的这种增加的方便性。另外地,通过在每次更换储液器时更换蓄 电池,用户可以更不容易使得蓄电池耗尽。 
一次性部分2610能够另外地或者可替代地包括处理器,该处理器可以用于,例如,在发生故障的情形中(例如,可再用部分中的主控制器的故障)继续某些器件的操作,以在发生故障的情形中产生警报,或者向可再用部分提供状态信息。关于状态信息,处理器能够保持跟踪一次性部分的操作历史以及各种特性并且保留状态信息以便在一次性部分2610的安装期间由用户、流体输送器件10和/或用户接口14访问。例如,处理器能够存储与保存限期、最大曝光或者操作温度、制造商、用于治疗的安全分配限制等有关的状态。如果所述器件确定这些状态指示器的任何一个不可接受,则所述器件能够拒绝向泵送组件和分配组件供电并且向用户示意一次性部分不可使用。处理器可以由可再用部分或者一次性部分中的蓄电池供电。 
更一般地,该器件可以被配置为经由条形码阅读器,或者经由RFID技术从任何一次性部分(包括,例如,一次性部分2610和在此使用的任何一次性构件,例如流体储液器、蓄电池或者尖锐的药筒或者各个尖锐的构件),例如,从置于一次性部分中的处理器,获得状态信息。如果所述器件探测到一次性部分存在问题(例如,用于可再用部分的无效模型编号或者流体过期),则所述器件可以采取补救动作,如,例如防止或者终止器件操作并且产生适当警报。 
另外的构件可以被包括在一些实施例中。例如,能够采用备用故障探测和通告机构。所述器件可以采用听觉警报器。传感器550的扩音器1202可以用于听觉警报器,或者另外的扬声器可以包括扩音器并且用于听觉警报器。器件振动机构3210也能够被用作警报器。如果探测到要求即刻关注的系统故障,则两个警报器均能够被致动。另外地,可以作为对主要蓄电池的备份而采用可充电蓄电池或者超级电容器。如果任一蓄电池均不能工作,则控制器能够致动一个或者多个警报器,从而发出蓄电池故障的至少一个通告。 
警报器还能够用于向用户示意器件正确工作。例如,用户可能关于在特定时期的推注输送而对所述器件编程。用户可能期望知道所编程的输送正确地进行。处理器能够使用振动马达或者音频声音以示意成功的编程输送。因此,在所述器件的一些实施例中能够采用一些机构以向患者或者用户提供肯定的或者否定的反馈。 
麦克风也可以用于探测任何异常振动或者正常振动的缺乏,并且触发警报状态。在各种实施例中,声学体积感测系统的麦克风可以用于执行这种监视,或者可以包括单独的麦克风以用于这种监视。也能够执行周期检查,以通过利用麦克风检查预期的泵振动而确定所述器件正在操作。如果麦克风探测到不正确的振动,或者如果正确振动未被探测到,则能够致动警报器。 
现在参考图71,概略示出器件10的各种构件。在器件10的一个实施例中,顶部X与基部Y配合并且储液器20被夹在顶部X和基部Y之间。夹紧作用力允许储液器隔片6272与基部Y相配合。在一些实施例中,输液器件5010和分析物传感器5020均通过基部Y插入并且进入患者(未示出)体内。 
在很多实施例中,基部Y和储液器20是一次性部分并且顶部X是非一次性部分。输液器件5010和分析物传感器也都是一次性的。 
如前所讨论的,贴片泵器件可以全部或者部分地是一次性的。图72示出具有一次性和非一次性部分的流体输送器件10的实施例。在该实施例中,一次性部分Y含有与流体直接接触的构件,包括可塌陷储液器20、泵送组件(未示出)、可变容积分配腔室122(分配组件120的位于顶部X上的一部分)和限流器(未示出),以及将储液器连接到至可变容积分配腔室122的泵送机构的流体路径(未示出)和单向阀(未示出)。另外地,一次性部分Y包括储液器空腔2645。 
可再用部分X包括分配组件120的元件,除了位于一次性部分Y上的可变容积分配腔室122。在一些实施例中,分配组件120是AVS组件。在上面详细描述了AVS组件。现在参考图73,集成声学体积测量传感器被示出是在PCB上的。 
现在参考图74,示出图49所示的器件10。基部一次性部分Y包括储液器空腔2645。顶部非一次性部分X包括蓄电池15和分配组件120。示出麦克风133以及膜片弹簧130。在一些实施例中,分配组件120包括多于一个的麦克风。虽然贯穿本说明,每一个麦克风均被称作133,但这并不示意麦克风总是相同的。在一些实施例中,麦克风是相同的,在其它实施例中,麦克风是不同的。 
在图74中,顶部非一次性部分X还包括主PCB13、振动马达3210和泵送致动部件54。顶部、非一次性部分X包括AVS组件或者分配组件120。在图74中,示出麦克风133。顶部、非一次性部分X还包括可以用于向非一次性部分和/或一次性部分上的电子器件供电的蓄电池15。在一些实施例中,该蓄电池15是可再充电的。能够通过在下面描述的方法进行再充电。一次性部分Y包括具有流动管线(未示出)和泵送组件的润湿构件。在图74中,仅仅泵送柱塞54能够看见。器件10的这个实施例能够还包括上述的很多元件,包括但不限于流阻、柔性隔膜、管罩和传感器壳体。能够使用任何泵送机构。 
现在参考图75,在其中可以看到更多元件的另一视图中示出器件10。在图75中,器件10被示为具有包括盘绕微管限流器340和连接进口21与出口22阀门的流动管线310的基部一次性部分Y。还示出泵送致动部件54。顶部X包括主PCB13、振动马达3210、两个麦克风133、扬声器134、基准腔室127和固定容积腔室129。还示出蓄电池15。因为对于限流器340选择非常小的直径,可能引起流动管线310堵塞(例如,由于在治疗流体中蛋白质聚合),因此可能期望使用具 有更大直径的长度更长的管线。然而,为了在贴片大小的壳体中包装具有更长长度的管线,可能必须弯曲管线以形成弯曲路径,例如盘绕的或者蛇形的。 
现在参考图76,示出图72、74和75所示的器件10的分解视图。顶部、非一次性部分X被示为与基部一次性部分Y分离。在实践中,储液器(未示出)将被置于顶部X和基部Y部分之间。一旦顶部X和基部Y被组装以形成器件10,则储液器将被连接到流动管线310。 
现在参考图77,示出包括一次性基部Y和非一次性顶部X部分的器件10的另一实施例的分解视图。还包括储液器20,保持输液器件5010与传感器5020的粘结剂3100和桥接5040设备。该器件10包括更加圆化的印迹和圆顶形状。蓄电池15和主PCB13被示为位于顶部X上。基部Y包括储液器空腔2645。在两件式实施例中示出粘结剂3100。桥接5040用于通过基部Y插入输液器件5010和传感器5020。储液器20被示为具有不规则形状,然而,在其它实施例中,储液器20能够根据所需流体容量具有任何形状并且能够改变尺寸。在器件10的该实施例中,非润湿构件位于顶部非一次性部分X中并且润湿构件位于基部一次性部分Y中。 
当被组装时,器件10可以利用粘结剂中央区域(未示出)被附着到一起。可替代地,器件10可以使用在这里描述的用于锁紧的很多实施例中的任何一个实施例以机械方式被锁定到一起。这里虽然在下面描述了一些实施例,但是很多其它实施例是显而易见的,并且当器件形状改变时,在很多情形中,锁具也将改变。 
现在参考图78,示出器件10的另一实施例的分解视图。顶部非一次性部分X为基本圆顶形状,然而,凸出Xl被示为容纳顶部X中的机构。因此,器件形状能够改变并且能够包括息肉部(polyps)和凸出、浅凹以及其它纹理状特征,以适合于所述器件的各种设计。 
示出储液器20、输液器件5010和传感器5020。输液器件5010和传感器5020能够通过基部Y插入并且进入患者(未示出)体内。基部Y被示为在下面具有粘结剂3100或者垫片3220。在实践中,粘结剂3100或者垫片3220能够首先被附着到皮肤和基部Y。接着,输液器件5010和传感器5020通过基部Y而插入患者体内(未示出,在图79中被示为5020和5010)。然后通过首先将储液器20置于顶部X中然后夹于顶部X和基部Y之间,或者,将储液器20置于储液器空腔2645中并且然后夹于顶部X和基部Y之间,将储液器20置于储液器空腔2645中。任一方式均可使用。最终结果是储液器20通过储液器20上的隔片(被颠倒地示出)和隔片针(未示出,见6272)被连接到位于基部Y中的流动管线(未示出)。然后,通过使用粘结剂,或者在该实施例中通过机械地使用锁具654将顶部X和基部Y夹在一起而将顶部X固定到基部Y。 
基部Y包括被润湿的那些构件。基部Y是一次性的。顶部X包括非润湿构件。顶部X是非一次性的。现在参考图79,基部Y包括可变容积分配腔室122、进口阀21以及出口阀22和泵送腔室2350。如该图所示,那些元件被示为覆盖用作腔室或阀门的区域的隔膜。因此,基部Y包括隔膜,该隔膜牢固地保持润湿区域,因此,保持了诸如在顶部(未示出)中的非润湿区域。如图79所示,传感器5020和输液器件5010已被插入它们相应的壳体中并且通过基部Y到达患者(未示出)。基部Y被示为具有储液器空腔2645,但是需要连接储液器(未示出),从而从储液器到腔室并且到输液器件的流动管线被连接了。 
现在参考图80,示出所述器件的顶部X。顶部X包括那些非润湿构件,包括,如图所示,温度传感器3216、膜片弹簧130、进口阀提升阀21以及出口阀提升阀22和泵送致动部件54。顶部Y还包括凹部2640以容纳储液器(未示出)。 
现在参考图81A-81C,示出用于示意在顶部X和基部Y之间夹住储液器20的过程的序列。如图81A所示,示出顶部X以及顶部X外部的储液器20。储液器包括隔片6270。顶部X包括储液器凹部2640。下面,如图81B所示,准备顶部以便与基部Y一起进行夹持。现在参考图81C,储液器20被置于基部Y中,其中隔片侧向下。隔片将与基部Y中的带有套管的隔片针(未示出)连接并且将储液器连接到流动管线(未示出)。在可替代实施例中,储液器可以包括带有套管的针而非隔片,并且流体路径可以包括带有隔片的储液器接口,而非带有套管的针。 
下面参考图82,示出顶部X,其中泵送机构16的一个实施例被分解。泵送机构16被装配到顶部X中的泵送机构壳体18内。也示出基部Y以及将顶部X和基部Y夹在一起的锁具654的一个部分。 
现在参考图83,示出基部Y,其中以流体路径组件166作为从基部Y分解的隔膜2356。这示意出在器件的一些实施例中,流体路径组件166是插入基部Y中并且利用隔膜2356夹住的独立部件。在该图中还示出,在一些实施例中的粘结剂或者垫片3100/3220包括用于输液器件和传感器(未示出)的孔隙。现在参考图84,示出基部Y的底视图。流体路径组件166的底部。 
现在参考图85A和85B,示出器件的另一实施例。在该实施例中,也是非一次性的顶部X包括推注按钮654。储液器20以分解视图示出,然而,在一个实施例中,储液器20被内置于基部Y中。在另一实施例中,储液器20是可移除的并且使用类似于在上面关于器件的另一实施例所述的过程被置于储液器空腔2645中。 
基部Y是一次性的并且包括器件10的润湿部分。传感器5020、套管5010、可变容积分配腔室122、进口阀区域21、出口阀区域22和泵送腔室2350。体积分配腔室、进口阀区域21、出口阀区域22和泵 送腔室2354均被隔膜材料覆盖,所述隔膜材料可以具有单一隔膜或者不同隔膜的形式。 
利用顶部X和基部Y上的锁具机构654将器件10夹到一起。现在参考图85C-85D,器件10是被示为处于打开位置(图85C)以及夹紧或者关闭位置(图85D)中的锁紧机构654。还能够看见如在上面更加详细描述的推注按钮3213。 
盖子(未示出)可以被提供用于所述器件实施例的任何一个中,以当储液器被移除而基部被连接到患者时替代储液器和顶部。所述盖子将不含电气构件,因此,可在湿润状态中使用。然而,在一些情形中,储液器能够被移除而不使用任何盖子。 
套管和插入器 
图86A概略示出输液和传感器组件5040的代表性实施例,所述组件包括能够是套管或者针5010的输液器件以及包括传感器探针5025和传感器基部5023的分析物传感器。桥接5070牢固地结合输液套管5010和分析物传感器基部5023。输液器件5010在上侧上由隔片5060界定,所述隔片允许流体从流体源流动并且通过输液器件5010供给到患者。传感器基部5023是分析物传感器的未被插入患者体内的部分。在一个实施例中,基部5023含有用于血液葡萄糖电化学分析的电触点。探针5025从分析物传感器5020的基部5023突出。 
现在参考图86B,在该实施例中,输液器件5010是使用引入针5240被引入患者体内的套管。当被插入患者体内时,引入针5240位于套管5010中。在将套管5010插入患者体内之后,引入针5240被移除并且隔片5060相对于流体源被密封,在这里描述的器件的一些实施例中,所述流体源是流动管线。在一些实施例中,传感器探针5025与引入针5072相关联,这有助皮肤穿刺,以插入传感器探针5025。当传感器探针5025被插入患者体内时,传感器引入针5072在一些实施例中至少 部分地围绕传感器探针5025。 
在其它实施例中,输液器件5010是针并且不需要引入针5240。在这些实施例中,输液器件5010被插入患者体内并且隔片5060密封流体源。 
在图86A和86B中,当输液器件5010和传感器探针5025均被适当排列时,作用力被施加到桥接5070。这迫使输液器件5010和传感器探针5025进入患者体内。一旦位于患者体内,则通过孔致动释放件5052,从而将输液器件5010和隔片5060分离,并且将传感器基部5023与桥接5070分离。参考图86B,其中使用了引入针5240和5072,它们通常在插入之后保持为接附到桥接5070。 
所述桥接能够由包括塑料的任何所需材料制成。套管能够是本领域中的任何套管。隔片5060能够由橡胶或者塑料制成并且具有能够产生所需功能的任何设计。在其中输液器件是针的实施例中,任何针均可被使用。在其中使用引入针的实施例中,任何的针、针器件或者引入器件均可被使用。 
输液和传感器组件要求施加作用力,从而被插入患者体内。而且,输液和传感器组件要求从输液和传感器组件释放输液器件和传感器。因此,作用力和释放件均能够被手动地致动,即,执行这些功能的人员,或者,插入器件可以被用于正确地致动所述组件。现在参考图87A-87E,示出能够被以手动方式操作的插入器5011的实例。输液器件5010和传感器5023被桥接5070保持。插入器5011包括用于输液器件5010和传感器5023两者的盖子5012。如图87B-87E所示,使用插入器5011,输液器件5010和传感器5023均被插入该器件10中。虽然图87A示出被暴露的尖锐物,但在一些实施例中,盖子5012在插入过程之前完全封装尖锐物。 
插入器5011能够被手动操作,但是也能够被结合在另一插入器器件中,从而能够应用机械优点。现在参考图88A-88B,插入器器件5013的一个实施例被用于类似于图87A-87E所示插入器5012的设备。插入器器件5013的机构被示于图88C-88D中。致动杠杆5014释放弹簧(如图88C-88D所示)或者提供允许插入器5012被插入器件(未示出)中的另一机械优点。插入器5012因此将释放输液器件5010和传感器5023并且然后插入器5012能够被从插入器器件5013移除并且插入器器件5013被再次填充,或者插入器器件5013和插入器5012能够被废弃。 
在这里描述了各种插入器件。然而,在其它实施例中,使用了不同的插入器件,或者输液器件和传感器被手动引入。 
可以包括用于将输液和传感器组件5040固定到自动插入器的特征。例如,在图86A-86B中被示为5052的释放件可以接收自动插入器件的销。参考图89A和89B,示出自动插入器5100的代表性实施例。如图89A的前视图所示,插入器5100包括在插入药筒凹部5120中的销狭槽5140内行进的销5130。在实践中,输液和传感器组件(未示出,在图86A和86B中示为5040)被压入药筒凹部5120中,引起销5130被插入输液和传感器组件中的孔内(在图86A和86B中被示为5052)。如图89B的后视图所示,压簧杆5145被用于准备插入器5100以便释放。插入器5100然后被保持到皮肤或者对准基部(未示出)上的管罩和传感器壳体并且通过压下触发器5110而被释放。当释放时,销5130在它们的狭槽5140中行进,由此迫使输液器件和传感器(均未示出)进入患者体内。插入器底脚5160限制输液和传感器组件向下行进。插入器也可以自动地从输液和传感器组件缩回引入针(未示出,见图86B)。 
在分配给终端用户之前,输液和传感器组件可以在插入器5100中被预加载。如图90所示,在其它实施例中,药筒5080可以用于保护用户并且保护在图56A和56B中被示为5040的组件中保持的尖锐物。 参考图90和图86A-86B以及图89A,在药筒实施例5080中,输液和传感器组件5040嵌入药筒5080中。药筒5080被安装在药筒凹部5120中。销5130可以通过孔5052突出并且进入药筒5080中的凹槽5090内。当致动插入器5100后,在药筒5080朝向患者行进时,销在凹槽5090中行进以插入尖锐物。药筒5080可以由刚性材料构造。 
现在参考图91A-91C,示出用于插入器的插入器机构的实施例的多个视图,例如在图89A和89B中被示为5100的一个。图91A示出插入器机构的一个实施例的透视图,图91B示出前视图,并且图91C示出侧视图。插入器5100具有压簧杆5145,它经由压簧连杆5350连接到锤体压簧滑块5330,并且用于将压簧滑块5330移动至负载位置。动力弹簧5390将锤体压簧滑块5330连接到触发器5110,并且,当被压缩时,提供插入输液器件或者输液和传感器组件(未示出)所必须的向下作用力。触发锤体5340被置于锤体压簧滑块5330的下方以及一对压簧连杆5350之间;触发锤体5340传递当压下触发器5110时从动力弹簧5390释放的动能。被激励的触发锤体5340冲击位于下方的药筒螺栓5380。药筒螺栓5380被联结到容纳药筒的药筒壳体5370,例如,在图90中示出其中一个。药筒螺栓5380也被置于回位弹簧5360的顶部上以将药筒壳体5350返回到缩退位置。 
图92A-92F概略示出用于翘起(cock)和释放具有参考图91A-91C所描述的类型的插入器5100的时间序列。图92A示出插入器5100处于停歇位置中。降低压簧杠杆(未示出,见图91A,5145)引起锤体压簧滑块5330降低并且接合触发锤体5340。图92B示出锤体压簧滑块5330处于降低的位置中,在该位置中它接合触发锤体5340。升高压簧杆引起锤体压簧滑块5330和锤体5340被升高,因此压缩动力弹簧5390;结果位置示于图92C中。在保证相对于基部(未示出)和/或患者皮肤正确定位插入器5100之后,触发器被压下,由此向下发送触发锤体5340;图92D示出处于运送中的触发锤体5340。如图92E所示,触发锤体5340冲击药筒螺栓5380,引起它向下行进,插入在药筒壳体 (未示出)中保持的一个或多个针,并且压缩回位弹簧5360。图92F示出回位弹簧5360处于向上促动药筒螺栓5380的过程中;这引起药筒壳体和其中包含的药筒(未示出)以及所使用的任何相关联的引入针后退。 
现在参考图93A-93C,示出用于将输液器件(即,套管或者针5010)插入并且固定到基部Y中的时间序列的一个实施例。图93A示出具有位于管罩5030上方的锁紧特征5210的基部Y。当插入输液器件或者套管5010时,基部Y通常靠着患者5220的皮肤定位。图93B示出迫使套管5010通过基部Y中的管罩5030。在该图中,使用引入针5240,它贯穿隔片(未示出)并且在套管5010中共轴地定位;引入针5240的尖锐点从套管5010的顶端(未示出)出现以便刺穿患者5220。在插入套管5010期间,弹性锁紧特征5210被推向一侧。图93C示出套管5010通过基部Y的管罩5030被完全插入,其中套管顶端被完全插入患者5220体内。引入针5240已被移除并且隔片5060已经相对于流体源或者流动管线(未示出)自密封。弹性锁紧特征5210接合套管5010,由此防止套管5010相对于基部Y移动。虽然图93A-93C示出套管5010,但是能够使用在图93A-93C中示出和描述的锁紧特征5210和方法将图86B所示的输液和传感器组件插入。 
现在参考图92G-92H,用以与插入器,例如在图91A-92F中示出的那一个一起使用的插入药筒螺栓锁紧机构被示为5100。药筒螺栓锁紧机构能够用作互锁,以防止当机构被翘起时的意外释放。锁紧机构包括制动件5420,当接合在制动件凹部5410中时该制动件5420防止药筒螺栓5380向下运动。如图92G所示,当压簧杠杆5145处于关闭位置时,压簧杠杆5145接触制动件杠杆5440,从而旋转制动件5420并且防止制动件5420被插入制动件凹部5410中。置于制动件5420和制动件弹簧支撑件5450之间的制动件弹簧5430处于压缩位置中。药筒螺栓5380和触发锤体5340自由移动。如图92H所示,当压簧杠杆5145旋转到向下位置中时,制动件杠杆5440被释放,由此允许制动件 弹簧5430迫使制动件5420被插入凹部中(这里制动件5420被示为位于凹部中,但是在图92G中所述凹部被示为5410);由此防止药筒螺栓5380的向下运动。压簧杠杆5145的返回进而将制动件5420返回到未锁定位置。药筒螺栓5380然后在触发过程中自由地向下运动。 
现在参考图94A-94C,示出将套管5010配合到基部Y并且与流动管线310形成流体连通的过程的一个实施例,其中套管是要求引入针的传统套管(如图86B所示)。图94A示出具有两个隔片(引入针隔片5062和流动管线隔片5270)的套管5010的截面视图。引入针隔片5062密封导向套管5010的中空针(未示出,在图94B中被示为5290)的通路5280。套管引入针5240被示为位于引入针隔片5062上方并且正好在插入引入针5240之前。 
现在参考图94B,引入针5240被示为通过引入针隔片5062插入。用户将套管5010配合到基部Y中,所述基部具有朝向上的刚性中空针5290。在将套管5010插入基部Y中期间,引入针5240刺穿流动管线隔片5270,以在流动管线310和通路5280之间形成流体连通。如果在将套管5010插入基部Y中期间基部Y被保持为抵靠患者(未示出),则在与患者皮肤被刺穿时间大约相同的时间在流动管线310和通路5280之间形成流体连通。现在参考图94C,示出被完全插入基部Y中的套管5010,其中引入针被移除并且与流动管线310形成流体连通。 
在可替代实施例中,通过与流体输送器件协作的振动马达辅助输液器件和/或传感器的插入。与输液器件和/或传感器的插入同时地,振动马达可以被致动。 
粘结剂 
现在参考图95,示出用于将例如流体输送器件10的物体固定到患者(未示出)皮肤的粘结剂贴片3100的一个实施例的顶部透视图。虽然粘结剂贴片3100被示为目前的形状,但是能够使用其它形状。可 以使用能够牢固地保持流体输送器件的任何粘结剂贴片3100。 
流体输送器件10被牢固地保持在通过粘结剂部件3111连结到患者皮肤的粘结剂贴片3100的中央区域3130的下面。 
这些粘结剂部件3111从中央区域3130以径向图案散开并且通过居间区域3121相互间隔。粘结剂部件3111的径向布置允许以牢固方式将器件10接附到患者。在一些实施例中,中央区域3130覆盖全部器件10,然而,在其它实施例中,中央区域3130覆盖器件10的一部分。中央区域3130还可以包括互锁接附特征(未示出),其可以由器件10的互补互锁特征(未示出)支持。在可替代实施例中,器件10被牢固地接附在中央区域3130的顶部上(例如,通过粘结剂或者互锁特征)。 
粘结剂贴片3100通常是扁平的并且由聚合物薄片或者织物构成。粘结剂贴片3100可以被供应有在一侧上粘附的粘结剂,并且受到例如可剥离塑料片的可剥离衬垫的保护,与贴片3100相比粘结剂将更加松散到附着到所述可剥离衬垫。所述衬垫可以是单一连续片,或者可以被划分成可被分别移除的多个区域。 
在示意性实施例中,用于中央区域3130的衬垫可以被移除而不移除用于粘结剂部件3111的衬垫。为了使用粘结剂贴片3100,用户移除中央区域3130的衬垫并且将器件10压向中央区域的新暴露出的粘结剂以将器件10接附到中央区域3130。用户然后将所述器件再次放置到皮肤上,从粘结剂部件3111移除衬垫,将粘结剂部件附着到皮肤,并且利用另外的部件重复附着过程。用户可以附着所有的粘结剂部件3111或者仅仅一些部件,并且节约另外的粘结剂部件3111以在另一天使用。因为通常用于连结到皮肤的粘结剂仅仅在数天内保持牢固地接附,因此在不同日期使用一组粘结剂部件3111(例如,每隔3到5天)将延长器件10保持牢固地接附到皮肤的时间并且减少再次应用所述器 件时经常涉及的时间、成本和不适感。不同的小片可以具有例如不同颜色或者数字的标记,以指示附着各种粘结剂部件3111的适当时间。粘结剂部件3111可以包括穿孔,使其相对于中央区域3130更加脆弱,从而所用的粘结剂部件可以在使用之后被移除。在上面参考图79-83讨论了用于延长使得器件10保持附着的持续时间的另外的实施例。 
图96概略示出流体输送器件10的截面视图,其中被插入的套管5010被牢固地保持在粘结剂贴片3100的下面。垫片3220可以被包括在器件10和患者皮肤3250之间并且允许空气流动到皮肤。可以通过在垫片3220中包括通路3230而增加到皮肤的空气流动。也可以通过使用相间隔的多个垫片或者通过利用高孔隙度材料构造垫片3220形成通路3230。因此,垫片3220能够具有任何形状和尺寸,并且在一些实施例中,垫片3220由多个分离的片构成。垫片3220可以在制造期间被附着到器件10的下侧,或者可以被用户附着到器件10。可替代地,垫片3220可以在使用粘结剂贴片3100之前被用户松散地放置到皮肤上。垫片3220可以包括柔顺材料,例如多孔聚合物泡沫。 
图97示出本发明的实施例,其使用第一粘结剂贴片3100和另外的粘结剂贴片3300以将器件(未示出)固定到患者。首先,器件(未示出)被定位以便使用并且利用使用片状-粘结剂部件3111的粘结剂贴片3100被固定到患者皮肤(未示出)。中央区域3130可以位于所述器件顶部上(如所示)或者固定在它的下面。在或长或短的一段时间之后,定位第二粘结剂贴片3300,以使它的中央区域位于第一粘结剂贴片3100的顶部上,并且第二粘结剂贴片的粘结剂部件3320在第一粘结剂贴片的粘结剂部件3111之间的居间区域中被固定到患者皮肤。可以提供脆弱区域以便移除与早期放置的贴片3100有关的松散的或者不需要的粘结剂部件3111。 
现在参考图98和99,示出其中粘结剂贴片3100已被划分成至少两个较小粘结剂贴片的实施例。在这些实施例中,粘结剂贴片3100被 划分成两个粘结剂贴片3410和3420,每一个均具有围绕中央空隙3430径向布置的粘结剂部件3111。该两个粘结剂贴片3410和3420每一个均展成大约180°的半圆,但是能够使用其它配置,例如:每一个均展开120°的三个贴片或者每一个均展开90°的四个贴片。在一些实施例中,粘结剂能够包括多于四个的贴片。关于这些实施例描述的配置遵照360°/n的公式,其中n是贴片数目。但是,在其它实施例中,根据器件的形状,不适用在这里示出和描述的公式。在另外的实施例中,所述贴片也可以覆盖多于360°的范围,并且因此交迭。 
如图99的透视图所示,由于存在中央空隙(未示出,在图98中示出),中央区域3130具有用于沿着器件10的周边附着定位的薄条带的形式。两个贴片3410和3420一起地将器件10牢固地接附到皮肤(未示出)。如在参考图95描述的实施例中,特别地当提供通路3230时,空气可以在粘结剂部件3111之间以及在器件10的下面流动。 
图100示出包括使用多个粘结剂贴片以延长使得器件10在移除之前保持附着到患者(未示出)的时间的实施例的透视图。当器件10被保持到位(或者通过其余粘结剂贴片3410和/或通过用户)时,多个部分粘结剂垫片3420中的一个被移除。被移除的粘结剂贴片3420然后被新的替代粘结剂贴片(未示出)所替代。替代粘结剂贴片可以与所移除的垫片3420相同或者可以具有粘结剂部件3111,该粘结剂部件3111位于可替代配置中以允许粘附到在之前被粘结剂贴片3420覆盖的区域之间的新的皮肤。然后可以以类似的方式更换其余的粘结剂贴片3410。例如颜色代码的标记可以用于指示粘结剂贴片的已用时间。贴片也可以具有颜色改变机构以指示它们的可用寿命已经到期。诸如图像和设计的装饰性图案可以被包括在贴片上。 
图101概略示出其中多个粘结剂部件3111被附着到患者12并且还经由系绳3730连接到环形中央区域3130的实施例。系绳3730可以是纤维或者绳索并且可以是弹性的以减轻器件10响应于患者12运动 而进行的运动。使用系绳3730还增加了对于粘结剂部件3111的皮肤位置而言可用的选择。 
用于图95-101所述实施例的粘结剂能够是可被用于患者皮肤上的任何有效和安全的粘结剂。然而,在一个实施例中,所用的粘结剂是3M产品编号9915,明暗纺织花边(value spunlace)医疗无纺胶带。 
夹紧和锁紧 
图102A-102C概略示出一种用于将流体输送器件的顶部和基部夹紧或者锁紧到一起的机构。首先参考图102A,示出夹具6410的正视图。图102B示出具有用于两个夹具的键孔6440的基部Y;相应的键孔也可以被包括在顶部(未示出)中。现在参考图102C,顶部X和基部Y可以对准并且夹具6410可以通过键孔(未示出,在图102B中被示为6440)插入。以90°旋转夹具6410引起柱杆6430移动到锁定位置中。压下凸轮杠杆6400,接合了铰接到夹具销6420的凸轮6415,以推压顶部X。结果,顶部X和基部Y利用夹紧作用力被保持在凸轮6415和柱杆6430之间。升高凸轮杠杆6400,释放了夹紧作用力,并且夹具6410可以旋转90°并且缩回以允许分开顶部X和基部Y。在一些实施例中,杠杆可以用作用于顶部X的保护盖。 
在图103A-103D中示出用于将所述器件的多个部分夹到一起的可替代实施例。图103A示出凸轮引导件6500的透视图并且图103B示出顶视图。凸轮引导件6500具有键孔6440和倾斜表面6510。图103C示出具有中央销6540的凸轮随动件6520,其中端头6560在第一端部处接附而杆6550接附到相对端部。如图103D的截面视图所示,凸轮随动件(未示出,在图103C中示出)可以被插入顶部X、基部Y和凸轮引导件6500中的键孔(未示出,示于图103C中)中。接附到中央销6540的杠杆6530的运动引起凸轮随动件(未示出,示于图103C中)旋转,这引起杆6550沿着倾斜表面(未示出,在图103C中示为6510)行进并且由此将旋转作用力转换成在凸轮随动件端头6560和杆6550 之间牢固地夹紧基部Y和顶部X的作用力。 
储液器 
在图104-106C中示出用于保持流体的可塌陷储液器的示例性实施例。可塌陷储液器具有当流体退出时凹陷的至少一个部分或者壁,由此在其内部中保持环境压力。在大多数实施例中,可密封端口(例如,隔片)被包括在储液器中。该端口允许利用注射器将流体填充倒该储液器并且还用于无泄露地连接到流动管线。可替代地,适配器可以用于将储液器连接到流动管线。可替代地,如在上面参考图71所示,针可以与储液器相关联并且隔片可以与流动管线的终端相关联。储液器可以由已知的与在储液器中包含的流体相容的塑料材料构造,即使对于非常短的持续时间。在一些实施例中,储液器是完全可塌陷的,即,储液器不包括任何刚性的本体表面。 
现在参考图104,示出储液器20的截面视图。在刚性储液器本体6200和柔性储液器隔膜6330之间形成用于保持一定体积流体的空腔2645。柔性隔膜6330围绕空腔2645的周边被密封地接附,以在空腔2645中容纳流体。柔性隔膜6330向储液器20赋予可塌陷性;当从空腔2645泵送流体时它向内变形。 
隔片6270坐靠在从本体6200延伸的颈部6240中。隔片6270用作空腔2645和流动管线之间的接口。在一些器件中,流动管线终止于针(未示出)。在这些实施例中,所述的针可以插入通过隔片6270,以通向空腔2645的针腔室6280部分。通过将隔片6270定位在端帽6250和凸缘(未示出)之间,隔片6270位置能够得以保持,其中该凸缘形成在针腔室6280的内壁6281与端帽钻孔6282的结合部处。在端帽钻孔6282中可以利用摩擦配合保持端帽6250。当插入端帽6250时,它的位置受到端帽钻孔6282的壁6261的限制。端帽6250的最靠近隔片6270的部分可以具有中央孔隙,以允许针通过端帽6250插入并且进入隔片6270中。可替代地,端帽6250可以被针刺穿。 
图105示出可塌陷储液器20内部的透视图。边沿6230允许接附柔性储液器隔膜,所述隔膜可以通过焊接、夹紧、附着或者其它适当方法接附,以形成流体密封。可以包括防护结构6290以允许流体流动到空腔2645或者从空腔2645流出,但是防止针进入空腔中,由此防止它可能刺穿储液器隔膜。 
图106A-106C示出储液器的可替代实施例,其中端帽6250将隔片6270密封地接附到储液器的壁6320。壁6320可以例如由柔性薄片构造,例如PVC、硅树脂、聚乙烯,或者由ACLAR薄膜构造。在一些实施例中,壁6320可以由利用ACLAR薄膜形成的可热成形聚乙烯薄片构造。柔性薄片与流体相容。所述壁可以接附到刚性壳体,或者例如可以通过折叠且焊接塑料薄片的端部所形成的柔性塑料袋的一部分。图106A示出经由圆形翼片6350密封到壁6320的端帽6250。隔片6270可以插入从端帽6250突出的转架6340中。转架6340可以由能够在高温下变形但是在室温下为刚性的材料构造,例如低密度聚乙烯。现在参考图106B,热压机6310或者用于熔化的另一设备或者过程被用于在隔片6270上熔化或者弯曲转架6340。现在参考图106C,隔片6270被示为固定到端帽6250。 
某些流体对于存储状态敏感。例如,胰岛素在运输过程中通常储存它的玻璃瓶中是一定程度地稳定的,但是当长期接触某些塑料时可能是不稳定的。在一些实施例中,储液器20由这种塑料构造。在此情形中,可以正好在使用之前利用流体填充储液器20,从而流体和塑料在较短时期内存在接触。 
储液器填充站 
现在参考图107,示出用于利用流体填充储液器20的储液器填充站7000。流体可以利用注射器7040从其初始容器抽出并且通过使用填充站7000而被引入储液器20中。填充站7000可以包括经由铰链7030 铰接到基本刚性的填充站盖7020的基本刚性的填充站基部7010。相应地,站7000可以被打开和关闭以接受并且保持储液器20。接附到注射器7040的针7050然后可以通过盖7020中的填充孔7060并且穿过储液器隔片6270被插入。因为填充站盖7020是刚性的,所以它对注射器7040的行进构成限制并且因此控制针7050穿入储液器20中的深度,以防止刺穿储液器20的下侧。当被支撑在表面上时,支腿7070将站7000保持在倾斜位置中。因为站7000被倾斜,所以当流体被从注射器7040注射进入储液器20中时,空气将趋于朝向隔片6270上升。在注射器7040将所需量的流体注射进入储液器20中之后,注射器7040可以被用于移除储液器20中的任何剩余空气。因为填充站基部7010和盖7020是刚性的,所以柔性储液器20通常不能扩大至超过固定容积并且防止对储液器20过度填充。基部7010和盖7020可以利用扣件被锁定到一起,或者沉重的盖子可以用于进一步阻止储液器过度膨胀和过度填充。 
现在参考图108A和108B,示出储液器填充站7000的可替代实施例。在该实施例中,储液器(未示出)被置于盖7020和基部7010之间的空间中。铰链7030接附盖7020和基部7010。如图108B所示,储液器(未示出)位于内部,并且注射器(未示出)针(未示出)被插入填充孔7060中。填充孔7060直接连接到储液器的隔片(未示出)。视窗7021以已被注射进入储液器的流体体积表示流动管线。 
流体输送系统通常包括流体输送器件和外部用户接口,但是在一些实施例中,完全的或者部分的内部用户接口被包括在器件中。所述器件能够是在这里描述的任何器件或者其变型。 
图109A示出用于流体输送系统的示例性实施例的数据采集和控制方案的流程图。患者或者保健人员利用外部用户接口14,该外部用户接口14通常为基站或者是独立于流体输送器件10而容纳的手持式单元。在一些实施例中,用户接口14与计算机、便携无线电话、个人 数字助理或者其它消费者器件集成。用户接口组件可以经由无线电频率发射(例如,经由LF、RF或者标准无线协议,例如“蓝牙”)与流体输送器件10进行连续或者间歇的数据通信,但是也能够经由数据电缆、光学连接或者其它适当数据连接而连接。外部用户接口14与处理器1504通信以输入控制参数,例如体重、流体剂量范围或者其它数据,并且接收状态和功能更新,例如存在由于堵塞流动、泄露、空储液器、不良蓄电池状态、需要维修、过期、所输送的或者剩余流体总量或者未认证的一次性构件而导致的任何错误状态。接口14可以通过电话、电子邮件、呼机、即时消息或者其它适当通信介质向患者监护人或者医疗专家传递错误信号。储液器致动器组件1519包括致动器1518和储液器1520。分配组件120向处理器1504传递与通过流动管线的流动有关的数据。处理器1504使用流动数据调节致动器1518的动作,以将源自储液器泵组件1519的流动增加或者降低为大致所需的剂量和定时。可选地,处理器1504的反馈控制器1506可以接收与储液器泵组件1519的操作有关的数据以探测状态,例如开放或者短路故障,或者致动器温度。 
图109B示出图102A中的流程图的可替代实施例。在该实施例中,分配组件/传感器的缺乏消除了基于流体体积的反馈。 
现在参考图110A,示出在流体输送系统中的流体输送器件的总体操作的一个实施例的流程图。用户使用开关或者从外部用户接口启动系统(步骤2800)。系统通过加载默认数值而被初始化,运行系统测试(步骤2810)并且获得可变参数,例如所需基础和推注剂量。可以由用户使用用户接口,即,使用例如用户接口上的触摸屏的输入器件或者通过从存储器加载所保存的参数,来选择可变参数(步骤2820)。基于预计的或者校准的流体输送器件的性能来计算致动器定时(步骤2830)。分配组件在流体输送器件致动开始时被启动(步骤2840)。分配组件数据收集2835通过致动和输送而继续。在操作期间,分配组件提供数据,该数据允许确定在一个或者多个时期内已经流过分配腔 室的流体的累积体积以及流率。流体输送器件被致动以引起流体流过流动管线并进入分配腔室(步骤2840)。药品以一定速率从分配腔室流动到患者,该速率由出口阻抗确定,并且在一些实施例中,由膜片弹簧施加的作用力以及由泵送组件施加的作用力所确定(步骤2860)。如果存在用户停止中断、低流动状态、基于预计的累积流动或者利用另外的储液器体积传感器的探测而确定了储液器为空的情况,或者系统的任一部分具有任何其它警报操作,或者具有用户规定的任何其它警报操作,则系统将停止并且通知用户(步骤2870)。如果不存在用户停止信号、储液器为空的确定或者另一警报指示器,则进行检查以确定是否由于实际和所需流率之间的偏差或者由于用户改变所需流率而需要调节致动器定时(步骤2880)。如果不需要进行调节,则该过程返回步骤2840。如果需要调节,则该过程返回步骤2830。现在参考图110B,示出流体输送系统中的流体输送器件总体操作的另一实施例的流程图。在该实施例中,基于用户输入的变化或者另一反馈作出调节致动定时的决定。在该实施例中,不包括具有用于确定体积的传感器的分配组件;因此基于可替代反馈机构进行调节。 
无线通信 
现在参考图111,示出在流体输送系统中使用线圈以用于感应充电和无线通信的实施例的布局。如前所述,用户接口组件14能够以与流体输送器件10无线通信的手持式用户接口组件14的形式实施。可以在流体输送器件10中采用二级线圈(即螺线管)3560,作为与无线控制器3580相结合的无线收发器天线。二级线圈3560也可以用作二级变压器,用于与蓄电池充电电路3540相结合地至少部分地对器件蓄电池3150充电。在该实施例中,用户接口组件14含有用于以感应方式将能量耦合至二级线圈3560的初级线圈3490。当用户接口组件14靠近流体输送器件10时,初级线圈3490激励二级线圈3560。被激励的二级线圈3560对蓄电池充电电路3540供电,以对流体输送器件10中的蓄电池3150充电。在一些实施例中,初级线圈3490还用作天线以与无线控制器3470相结合地发射和从流体输送器件10接收信息。 
现在参考图112,一些实施例在流体输送器件10中包括远程无线通信(例如,20-200英尺或者更远)硬件。因此,可以远程监视流体输送器件10。 
仍然参考图112,通常由患者携带的中间收发器6600能够提供远程通信的优点,同时不增加流体输送器件10的尺寸、重量和功耗。如图112的数据流图表所示,可配戴流体输送器件10使用短程硬件以及相关软件将数据发射向中间收发器6600或者从其接收数据。例如,器件10可以被配备成在大致3-10英尺的距离上发射数据。然后中间收发器6600可以接收该数据并且使用远程硬件和软件向用户接口组件14中转该数据。中间收发器6600也可以从用户接口组件14接受控制信号并且向器件10中转这些信号。可选地,用户接口组件14也可以能够与位于范围中的流体输送器件10直接通信。这种直接通信可以被配置为仅发生在中间收发器6600未被探测到时或者可替代地在用户接口组件14和流体输送器件处于彼此范围中的任何时候。 
可以以此方式发射很多类型的数据,包括但不限于: 
与泵致动定时和体积测量有关的数据以及来自分配组件的其它数据可以被发射到中间收发器6600并且被顺次发射到用户接口组件14; 
警报信号可以发射到流体输送器件10并且可以从流体输送器件10被发射; 
可以从用户接口14向中间收发器6600以及从中间收发器6600向流体输送器件10发射用以确认数据接收的信号; 
可以使用中间收发器6600从用户接口组件14向流体输送器件10发射用于改变器件10的操作参数的控制信号。 
现在参考图113,示出中间收发器6600的特定实施例的平面图。短程收发器6610与附近的流体输送器件通信。器件的短程收发器和中间收发器6600可以使用很多协议的一个或者多个协议以及已知的用于 短程通信的发射频率(例如无线电频率发射)进行通信。中间收发器6600接收的数据被输送到可以在存储器6620(例如,闪存芯片)中存储数据的微处理器6630,并且根据需要检索数据。微处理器6630还被连接到与用户接口进行数据通信的远程收发器6640。例如,中间收发器6600和用户接口组件可以根据蓝牙标准操作,所述蓝牙标准是使用大约2.45MHz的无线电频率并且可以在达大约30英尺的距离上操作的扩展频谱协议。Zigbee标准是在大约2.4GHz、915MHz以及868MHz的ISM频带中操作的可替代标准。然而,可以使用任何无线通信。 
可选地,微处理器6630分析所接收的数据以探测与所述器件有关的故障情况或者维修需要。故障状态的一些实例包括但不限于: 
在超过设定限制的时期中缺少被接收的数据; 
缺少来自器件或者用户接口组件的数据接收确认信号; 
设备存储器6620的溢流或者近溢流状态; 
低功率; 
从流体输送器件10接收到过高、过低或者不正确定时的体积测量。 
基于该故障分析,微处理器6630可以触发警报器6650(例如,铃或者蜂鸣器)。微处理器6630还可以向远程器件通信警报状态。远程器件可以是,例如,使用远距离收发器6640的用户接口组件、使用近距离收发器的流体输送器件10、或者用户接口组件和流体输送器件两者。当接收到警报器信号时,用户接口组件然后可以经由更长距离将警报器信号中转到医疗专家或者患者监护人(例如,通过呼机或者电话或者其它通信方法)。 
电源6670可以是可再充电的,并且可以存储足够的能量以连续操作一段时间,例如,至少10个小时。然而,操作时间将基于用途和器件改变。流体输送器件的尺寸可以减少从而它可以容易地在衣袋、钱包、公文包、背包等中携带。器件的一个实施例包括用于承受常规冲 击或者溢流的装置。在一些实施例中可以包括另外的特征,包括但不限于装饰性特征或者例如能够玩电视游戏、发送和接收即时消息、观看数字视频、听音乐等的大范围的消费电子器件的能力中的任何一个。可以包括第三方控制以在一天的一段时间或者所有时间期间取消或者限制这种功能的使用。可替代地,该器件可以尽可能得小和简单,并且仅仅用于在更长距离上重复近距离信号。例如,存储器和分析能力可以被省去。 
现在参考图114,示出用于系统实施例的数据流图表。中间收发器6600被示为用作通用患者接口,该通用患者接口与多个器件进行近距离通信并且将来自那些器件的信息经由长距离中转到与那些器件相关的一个或者多个用户接口。器件的实例包括可配戴、可移植或者内部的医疗器件,包括流体输送系统、葡萄糖传感器、具有集成应变传感器的膝关节、药丸形式的工具电子探针、去纤颤器、起搏器以及其它可配戴的治疗输送器件。因为不同类型的器件以及来自不同制造商的器件可以利用不同的近距离通信标准和频率,所以中间收发器6600可以包括支持多个协议的硬件(例如,多个天线和电路)和软件。 
蓄电池充电器 
现在参考图115和116。示出用于对蓄电池再充电的设备的一个实施例7100。在图15中,流体输送器件2620的顶部、非一次性部分被示为从流体输送器件的基部、一次性部分断开。蓄电池充电器7100用于对顶部2620中的蓄电池(未示出)充电。在图116中,顶部2620被示为位于蓄电池充电器7100上。锁具6530示为被关闭,将顶部2620连接到蓄电池充电器7100。因此,用于将顶部2620连接到基部(未示出)的锁具6530还用于将顶部2620连接到蓄电池充电器7100。对接可以形成直接电力连接,或者可以利用感应耦合转移电力。而且,在系统的一些实施例中,患者采用旋转的多个非一次性部分2620;即,当使用第二非一次性部分(未示出)时对一个非一次性部分2620充电。 
在这里描述的各种实施例包括不同类型和配置的元件,如,例如泵构造、泵致动器、体积传感器、限流器、储液器(以及储液器接口)、尖锐插入器、壳体、锁定机构、用户接口、内置(on-board)外设(例如控制器、处理器、电源、网络接口、传感器)以及其它外设(例如,手持式远程控制器、基站、转发器、填充站)。应该指出可替代实施例可以结合这些元件的各种组合。因此,例如,参考一个实施例描述的泵结构(例如,参考图15-15D示出和描述的泵)可以与各种配置的泵致动器(例如,具有单一操作模式的单一形状记忆致动器、具有多种操作模式的单一形状记忆致动器、相同尺寸或者不同尺寸的多个形状记忆致动器)中的任何一种一起使用,并且可以用于具有其它元件的各种组合(或者不存在其它元件)和/或各种限流器的任何一种限流器的器件。 
进而,虽然在这里参考非加压储液器描述了各种实施例,但应该指出在某些实施例中或者在某些状态(例如,在灌注和/或排气期间)下可以使用加压储液器。特别地,例如跟随参考图15A-15D示出和描述的泵致动部件54的回缩,加压储液器可以便于填充泵腔室。 
另外地,虽然在这里参考置于壳体可再用部分中的泵马达描述了各种实施例,但应该指出泵和/或泵马达可以可替代地例如与接触流体的各种构件一起地位于一次性部分中。如关于在这里描述的其它马达中的一些,置于一次性部分中的马达可以包括一个或者多个形状记忆致动器。 
应该指出为方便起见包括了部分标题,并且它们并非旨在限制本发明范围。 
在各种实施例中,在这里披露的包括用于控制并测量流体流动以及用于在相关构件之间建立通信的那些操作的方法可以作为计算机程序产品实现,所述产品用以与适当的控制器或者其它计算机系统(在 这里通常被称为“计算机系统”)一起使用。这种实现可以包括计算机指令序列,该计算机指令序列固定在有形介质上,例如计算机可读介质(例如磁碟、CD-ROM、ROM、EPROM、EEPROM或者硬盘),或者能够经由例如通过介质连接到网络的通信适配器的调制解调器或者其它接口器件而传输到计算机系统上。所述介质可以是有形介质(例如光学或者模拟通信线路)或者是利用无线技术(例如微波、红外或者其它发射技术)实现的介质。计算机指令序列可以实现在这里关于所述系统在前面描述的所需功能性。本领域技术人员应该理解这种计算机指令能够以多种编程语言编程,以用于很多种计算机体系或者操作系统。 
进而,这种指令可以被存储在任何存储器器件,例如半导体、磁的、光的或者其它存储器器件中,并且可以使用任何通信技术(例如光学、红外、声学、无线电、微波或者其它发射技术)被发射。期望这种计算机程序产品可以作为具有附带的打印或者电子文献(例如,收缩包装软件)的可移除介质而分发,利用计算机系统预加载(例如在系统ROM、EPROM、EEPROM或者硬盘上)、或者经由网络(例如互联网或者万维网)由服务器或者电子公告牌分发。当然,本发明的一些实施例可以以软件(例如计算机程序产品)和硬件组合的形式实施。本发明另外的实施例全部作为硬件或者基本以软件(例如计算机程序产品)的形式实施。 
应该指出在这里列出的尺寸、大小和数量是示例性的,并且本发明绝不受限于此。在本发明的示例性实施例中,贴片大小的流体输送器件的长度可以为大致6.35cm(~2.5英寸)、宽度大致为3.8cm(~1.5英寸)并且高度大致为1.9cm(~0.75英寸),但是,同样,这些尺寸仅仅是示例性的,并且对于不同实施例尺寸能够大范围地改变。 
虽然已经在这里描述了本发明的原理,但本领域技术人员应该理解该说明仅通过实例方式给出,而非作为对本发明范围的限制。除了 在这里示出和描述的示例性实施例,在本发明范围还可构思其它实施。由本领域普通技术人员作出的修改和替代被认为属于本发明的范围。 

Claims (92)

1.一种用于分配流体的器件,所述器件包括:
贴片大小的壳体,所述壳体封装与下游阻流弯曲导管串联的加压流体源。
2.根据权利要求1的器件,还包括:
用于测量与到达所述导管的流体流有关的参数的传感器;以及
用于基于所测量参数调节所述流体流的控制环。
3.根据权利要求1的器件,其中,所述流体源包括以可操作方式联接以向下游阻流弯曲导管提供加压流体的泵。
4.根据权利要求3的器件,其中,所述泵包括:
泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,和泵出口;以及
适于向所述泵送腔室提供压缩冲程的作用力施加组件,
其中当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程对于流体通过所述进口从所述泵送腔室的倒流产生限制。
5.根据权利要求4的器件,其中,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体从所述泵送腔室被促动到所述泵出口时,所述压缩冲程致动在所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。
6.根据权利要求5的器件,其中,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器的协作操作。
7.根据权利要求6的器件,其中,所述马达包括形状记忆致动器。
8.根据权利要求7的器件,其中,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。
9.根据权利要求3的器件,还包括与所述泵的输出和流体源流体连通的分流线,所述分流线允许由所述泵喷射的流体的一部分返回到所述流体源。
10.根据权利要求9的器件,其中,所述流体源包括非加压流体储液器。
11.根据权利要求3的器件,还包括:
用于测量与到所述导管的流体流有关的参数的传感器;和
用于基于所测量的参数调节所述泵的操作的控制环。
12.根据权利要求3的器件,其中,所述流体源还包括以可操作方式联接以向所述泵提供流体的非加压储液器。
13.根据权利要求1的器件,其中,所述阻流弯曲导管包括盘管。
14.根据权利要求13的器件,其中,所述盘管包括至少两个弯头。
15.根据权利要求1的器件,其中,所述阻流弯曲导管具有蛇形形状。
16.根据权利要求1的器件,其中,所述壳体包括一次性部分,该一次性部分具有包括所述阻流弯曲导管的一体的流体路径。
17.根据权利要求1的器件,其中,所述导管被置于所述壳体中。
18.根据权利要求1的器件,其中,所述导管具有基于所述流体的粘度和密度的至少一个,为提供预定阻抗而选择的长度和内径。
19.根据权利要求1的器件,其中,所述内径足够大从而防止由于治疗液体通过所述导管的流动而被堵塞。
20.根据权利要求1的器件,其中,所述导管具有大于2cm的长度。
21.根据权利要求1的器件,其中,所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。
22.根据权利要求1的器件,还包括:
与所述流体源和所述导管流体连通的分配腔室,所述分配腔室包括进口和出口,通过该进口从所述流体源接收流体,通过该出口向所述导管提供流体。
23.根据权利要求22的器件,其中,所述导管具有小于所述分配腔室进口的内径的内径。
24.根据权利要求22的器件,其中,所述分配腔室是弹性的可变容积分配腔室。
25.根据权利要求22的器件,其中,所述导管具有小于所述进口的有效直径的有效直径。
26.一种用于分配流体的器件,所述器件包括:
贴片大小的壳体;
置于所述壳体中的泵,所述泵具有泵出口;
同样置于所述壳体中的分配腔室,所述分配腔室具有分配进口和分配出口,其中所述分配进口联接到所述泵出口;以及
联接到所述分配出口以提供流阻的弯曲导管。
27.根据权利要求26的器件,还包括:
用于测量与到所述导管的流体流有关的参数的传感器;和
用于基于所测量的参数调节所述泵的操作的控制环。
28.根据权利要求26的器件,还包括:
置于所述壳体中并且以可操作方式联接以向所述泵的进口提供流体的非加压储液器。
29.根据权利要求26的器件,其中,所述弯曲导管包括盘管。
30.根据权利要求29的器件,其中,所述盘管包括至少两个弯头。
31.根据权利要求26的器件,其中,所述弯曲导管具有蛇形形状。
32.根据权利要求26的器件,其中,所述壳体包括一次性部分,该一次性部分具有包括所述弯曲导管的一体的流体路径。
33.根据权利要求26的器件,其中,所述导管被置于所述壳体中。
34.根据权利要求26的器件,其中,所述导管具有大于2cm的长度。
35.根据权利要求26的器件,其中,所述壳体具有最大尺寸,并且所述导管具有大于所述最大尺寸的长度。
36.根据权利要求26的器件,其中,所述导管包括基于所述流体的粘度和密度的至少一个,为提供预定阻抗而选择的有效直径。
37.根据权利要求26的器件,其中,所述导管具有基于所述流体的粘度和密度的至少一个,为提供预定阻抗而选择的长度和内径。
38.根据权利要求26的器件,其中,所述分配腔室是弹性的可变容积分配腔室。
39.根据权利要求26的器件,其中,所述分配腔室具有进口,并且所述导管具有小于所述分配腔室进口的内径的内径。
40.根据权利要求26的器件,其中,所述泵包括:
泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,和泵出口;以及
适于向所述泵送腔室提供压缩冲程的作用力施加组件,
其中当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程对于流体通过所述进口从所述泵送腔室的倒流产生限制。
41.根据权利要求40的器件,其中,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体从所述泵送腔室被促动到所述泵出口时,所述压缩冲程致动在所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。
42.根据权利要求41的器件,其中,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器的协同操作。
43.根据权利要求42的器件,其中,所述马达包括形状记忆致动器。
44.根据权利要求43的器件,其中,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。
45.根据权利要求26的器件,还包括与所述泵出口和流体源流体连通的分流线,所述分流线允许由所述泵喷射的流体的一部分返回到所述流体源。
46.根据权利要求45的器件,其中所述流体源包括非加压流体储液器。
47.一种用于测量通过管线输送的流体流的方法,该方法包括:
在由联接到声学邻接区域的子区域空间的区域中的流体流引起的该子区域的容积变化期间,仅仅在单一频率下以声学方式激发所述声学邻接区域中的气体,以产生声学响应;
确定在所述声学邻接区域中的第一位置处测量的声学响应和用于所述单一频率的基准之间的相位关系;
基于所述相位关系的时间演变,计算所述子区域的容积变化;并且
基于所述子区域中的气体的体积变化,推断通过所述管线的流体流的测量结果。
48.根据权利要求47的方法,还包括在所述声学邻接区域中的第二位置处测量所述基准。
49.根据权利要求47的方法,其中,所述区域经由隔膜联接到所述子区域的空间。
50.根据权利要求47的方法,其中,以声学方式激发气体的步骤包括驱动转换器。
51.根据权利要求47的方法,其中,以声学方式激发气体的步骤包括驱动扬声器。
52.根据权利要求47的方法,还包括作为所述子区域的容积的函数来校准所述相位关系。
53.根据权利要求47的方法,其中,所述声学邻接区域具有小于200微升的容积。
54.根据权利要求47的方法,其中,所述声学邻接区域具有小于130微升的容积。
55.根据权利要求47的方法,其中,所述声学邻接区域具有小于10微升的容积。
56.根据权利要求47的方法,其中,计算所述容积变化包括以优于20纳升的分辨率确定这种变化。
57.根据权利要求47的方法,其中,计算所述容积变化包括以优于15纳升的分辨率确定这种变化。
58.根据权利要求47的方法,其中,计算所述容积变化包括以优于13纳升的分辨率确定这种变化。
59.根据权利要求47的方法,其中,计算所述容积变化包括以所述声学邻接区域的容积的至少万分之一的分辨率确定这种变化。
60.根据权利要求47的方法,其中,所述单一频率是或者接近所述子区域的共振频率。
61.根据权利要求47的方法,还包括:
通过在一连串频率下以声学方式激发所述区域并且确定传递函数来运行校准阶段,所述传递函数表征在所述声学邻接区域中的第一位置处测量的声学响应和作为频率的函数的用于所述一连串频率的每一个频率的基准之间的相位关系。
62.根据权利要求61的方法,还包括在所述声学邻接区域中的第二位置处对于所述一连串频率的每一个频率测量所述基准。
63.根据权利要求61的方法,还包括基于所述传递函数探测气泡的存在。
64.根据权利要求63的方法,还包括当探测到气泡存在时进入警报状态。
65.根据权利要求61的方法,其中所述容积变化的计算在测量阶段期间重复执行,并且所述测量阶段与所述校准阶段交替地执行。
66.根据权利要求65的方法,其中循环地输送流体,并且所述校准和测量阶段与所述循环相协作。
67.一种用于测量通过管线输送的流体流的系统,所述系统包括:
声学能量源,所述声学能量源用于在由联接到声学邻接区域的子区域空间的区域中的流体流而引起的该子区域的容积变化期间,仅仅在单一频率下以声学方式激发所述声学邻接区域中的气体以产生声学响应;
第一声转换器,其安装在所述声学邻接区域中的第一位置处,以基于所述声学响应产生电信号,所述第一声转换器的电信号关于基准具有相位关系;以及
处理器,所述处理器联接到所述第一声转换器和所述基准,执行流动确定过程,以基于所述相位关系的时间演变而确定与所述子区域的容积变化有关的量;并且基于所述子区域中的气体的体积变化推断通过所述管线的流体流的测量结果。
68.根据权利要求67的系统,还包括第二声转换器,该第二声转换器安装在所述声学邻接区域中的第二位置处,以用于产生构成所述基准的电信号。
69.根据权利要求67的系统,其中,所述系统具有小于每日500焦耳的功耗。
70.一种流体输送系统,其利用根据权利要求67的用于测量通过管线输送的流体流的系统,所述流体输送系统造成通过所述管线输送的流体流,并且还包括:
联接到处理器的泵;
其中所述处理器的功耗并不显著大于所述泵的功耗。
71.根据权利要求70的系统,其中,所述泵包括:
泵送腔室,所述泵送腔室具有能够连接以提供与流体源流体连通的进口,和泵出口;以及
适于向所述泵送腔室提供压缩冲程的作用力施加组件,
其中当从所述泵送腔室到所述泵出口促动流体时,所述压缩冲程对于流体通过所述进口从所述泵送腔室的倒流产生限制。
72.根据权利要求71的系统,其中,所述作用力施加组件联接到进口阀门致动器和泵致动器,从而当所述泵致动器使得流体从所述泵送腔室被促动到所述泵出口时,所述压缩冲程致动在所述进口和所述流体源之间联接的进口阀门,以关闭所述阀门。
73.根据权利要求72的系统,其中,所述作用力施加组件包括板,该板联接到所述阀门致动器、所述泵致动器、以及马达,用于所述阀门致动器和所述泵致动器的协同操作。
74.根据权利要求73的系统,其中,所述马达包括形状记忆致动器。
75.根据权利要求74的系统,其中,所述马达包括用于折叠所述形状记忆致动器以使其适配于可再用部分中的至少一个滑轮。
76.根据权利要求67的系统,还包括将所述区域联接到所述子区域空间的隔膜。
77.根据权利要求67的系统,其中,所述声学能量源包括耦合电信号的声转换器。
78.根据权利要求67的系统,其中,所述转换器是扬声器。
79.根据权利要求67的系统,其中,所述处理器执行校准过程,该校准过程用于作为所述子区域容积的函数而校准所述相位关系。
80.根据权利要求67的系统,其中,所述声学邻接区域具有小于200微升的容积。
81.根据权利要求67的系统,其中,所述声学邻接区域具有小于或等于130微升的容积。
82.根据权利要求67的系统,其中,所述声学邻接区域具有小于10微升的容积。
83.根据权利要求67的系统,其中,所述流动确定过程以相应于优于20纳升的分辨率确定与容积变化有关的量。
84.根据权利要求67的系统,其中,所述流动确定过程以相应于优于15纳升的分辨率确定与容积变化有关的量。
85.根据权利要求67的系统,其中,所述流动确定过程以相应于优于13纳升的分辨率确定与容积变化有关的量。
86.根据权利要求67的系统,其中,所述流动确定过程以相应于所述声学邻接区域的容积的至少万分之一的分辨率确定与容积变化有关的量。
87.根据权利要求67的系统,其中,所述单一频率是或者接近所述子区域的共振频率。
88.根据权利要求67的系统,其中:
所述声源包括联接到所述处理器的声音发射转换器;
所述处理器实施校准过程,在该过程中它引起所述声源以声学方式在一连串频率下激发所述区域;并且,作为这种过程的一个部分,所述处理器确定表征在所述第一转换器的电信号和作为频率的函数的用于所述一连串频率的每一个频率的基准之间的相位关系的传递函数。
89.根据权利要求88的系统,其中,所述处理器执行用于基于所述传递函数探测气泡的存在的气泡探测过程。
90.根据权利要求89的系统,其中,当探测到气泡存在时,所述气泡探测过程使得所述系统进入警报状态。
91.根据权利要求90的系统,其中,所述流动确定过程在测量阶段期间重复地执行,并且所述测量阶段与所述校准阶段交替地执行。
92.根据权利要求91的系统,其中,循环地输送流体,并且校准过程和测量阶段与所述循环相协作。
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105816943A (zh) * 2015-01-27 2016-08-03 韦贝尔Cds公司 一种无菌条件下给送流体的定量给药装置
CN105943381A (zh) * 2016-05-06 2016-09-21 中国人民解放军第三军医大学第附属医院 三升袋挤压器
CN109922847A (zh) * 2016-11-01 2019-06-21 赛诺菲-安万特德国有限公司 体积测量组件
CN110383041A (zh) * 2017-03-03 2019-10-25 国立大学法人熊本大学 光学测定系统、光学单元以及光学测定方法
CN112384268A (zh) * 2018-07-11 2021-02-19 生物技术公司 药物输送系统

Families Citing this family (745)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9028498A (en) 1997-08-22 1999-03-16 Deka Products Limited Partnership System, method and cassette for mixing and delivering intravenous drugs
US20120209197A1 (en) * 2002-01-04 2012-08-16 Lanigan Richard J Infusion pump assembly
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
EP2140891B1 (en) 2001-05-18 2013-03-27 DEKA Products Limited Partnership Conduit for coupling to a fluid delivery device
US6852104B2 (en) 2002-02-28 2005-02-08 Smiths Medical Md, Inc. Programmable insulin pump
US20080172026A1 (en) 2006-10-17 2008-07-17 Blomquist Michael L Insulin pump having a suspension bolus
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
EP1552146B1 (en) 2002-10-09 2011-04-20 Abbott Diabetes Care Inc. Fluid delivery device, system and method
EP1578262A4 (en) 2002-12-31 2007-12-05 Therasense Inc CONTINUOUS BLOOD SUGAR MONITORING SYSTEM AND USE METHOD
US7263501B2 (en) * 2003-03-11 2007-08-28 I-Stat Corporation Point-of-care inventory management system and method
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7299082B2 (en) * 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
EP1680175B1 (en) 2003-11-06 2019-06-05 LifeScan, Inc. Drug delivery pen with event notification means
HK1077154A2 (en) 2003-12-30 2006-02-03 Vasogen Ireland Ltd Valve assembly
WO2005089103A2 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
CA2572455C (en) 2004-06-04 2014-10-28 Therasense, Inc. Diabetes care host-client architecture and data management system
US7310544B2 (en) 2004-07-13 2007-12-18 Dexcom, Inc. Methods and systems for inserting a transcutaneous analyte sensor
US8202248B2 (en) 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US20100331646A1 (en) * 2009-06-30 2010-12-30 Abbott Diabetes Care Inc. Health Management Devices and Methods
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US7697967B2 (en) * 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
EP1863559A4 (en) 2005-03-21 2008-07-30 Abbott Diabetes Care Inc METHOD AND SYSTEM FOR PROVIDING AN INTEGRATED MEDICINE INFUSION SYSTEM AND ANALYTICAL MONITORING SYSTEM
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US7998134B2 (en) 2007-05-16 2011-08-16 Icu Medical, Inc. Medical connector
US7803139B2 (en) 2005-07-06 2010-09-28 Icu Medical, Inc. Medical connector with closeable male luer
WO2008048234A2 (en) 2005-08-26 2008-04-24 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
PL1762259T3 (pl) 2005-09-12 2011-03-31 Unomedical As Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową
US8545445B2 (en) * 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US11497846B2 (en) 2006-02-09 2022-11-15 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US11286921B2 (en) 2006-02-09 2022-03-29 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US11318249B2 (en) * 2006-02-09 2022-05-03 Deka Products Limited Partnership Infusion pump assembly
US8579884B2 (en) 2006-02-09 2013-11-12 Deka Products Limited Partnership Infusion pump assembly
US11478623B2 (en) 2006-02-09 2022-10-25 Deka Products Limited Partnership Infusion pump assembly
US11364335B2 (en) 2006-02-09 2022-06-21 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
DE602007012417D1 (de) 2006-03-14 2011-03-24 Univ Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
US9717834B2 (en) 2011-05-24 2017-08-01 Deka Products Limited Partnership Blood treatment systems and methods
US10537671B2 (en) 2006-04-14 2020-01-21 Deka Products Limited Partnership Automated control mechanisms in a hemodialysis apparatus
US7794141B2 (en) 2006-04-14 2010-09-14 Deka Products Limited Partnership Thermal and coductivity sensing systems, devices and methods
US9119582B2 (en) 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8202267B2 (en) 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
KR100730582B1 (ko) * 2006-11-20 2007-06-20 아람휴비스(주) 이온토포레시스 장치
US9895494B2 (en) * 2007-01-25 2018-02-20 DePuy Synthes Products, Inc. Syringe with energy delivery component and method of use
US8430837B2 (en) 2007-02-05 2013-04-30 Boston Scientific Scimed, Inc. Thrombectomy apparatus and method
US20080199894A1 (en) 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
EP1961436B1 (de) * 2007-02-24 2016-08-24 Roche Diabetes Care GmbH Infusionssystem
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
KR101861192B1 (ko) 2007-02-27 2018-05-28 데카 프로덕츠 리미티드 파트너쉽 혈액투석 장치 및 방법
US10463774B2 (en) 2007-02-27 2019-11-05 Deka Products Limited Partnership Control systems and methods for blood or fluid handling medical devices
US20090107335A1 (en) 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US8393690B2 (en) 2007-02-27 2013-03-12 Deka Products Limited Partnership Enclosure for a portable hemodialysis system
US8491184B2 (en) 2007-02-27 2013-07-23 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
MX2009010000A (es) 2007-03-19 2010-03-17 Insuline Medical Ltd Dispositivo para el suministro de farmaco.
WO2009081262A1 (en) * 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US8333361B2 (en) * 2007-04-09 2012-12-18 Masco Corporation Of Indiana Wireless power transfer device for a fluid delivery apparatus
EP2146625B1 (en) 2007-04-14 2019-08-14 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
EP4108162A1 (en) 2007-04-14 2022-12-28 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
WO2008130896A1 (en) 2007-04-14 2008-10-30 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
US9615780B2 (en) 2007-04-14 2017-04-11 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2008130895A2 (en) 2007-04-14 2008-10-30 Abbott Diabetes Care, Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8260558B2 (en) 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US10002233B2 (en) 2007-05-14 2018-06-19 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8026382B2 (en) * 2007-05-18 2011-09-27 Heidi Kay Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods
US20090069830A1 (en) * 2007-06-07 2009-03-12 Piezo Resonance Innovations, Inc. Eye surgical tool
EP3533387A3 (en) 2007-06-21 2019-11-13 Abbott Diabetes Care, Inc. Health management devices and methods
CA2690870C (en) 2007-06-21 2017-07-11 Abbott Diabetes Care Inc. Health monitor
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8085151B2 (en) 2007-06-28 2011-12-27 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
US8328738B2 (en) * 2007-06-29 2012-12-11 Actuated Medical, Inc. Medical tool for reduced penetration force with feedback means
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
US10219832B2 (en) 2007-06-29 2019-03-05 Actuated Medical, Inc. Device and method for less forceful tissue puncture
US9987468B2 (en) 2007-06-29 2018-06-05 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US8043229B2 (en) * 2007-06-29 2011-10-25 Actuated Medical, Inc. Medical tool for reduced penetration force
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US8442390B2 (en) * 2007-08-29 2013-05-14 Philip Morris Usa Inc. Pulsed aerosol generation
US20090143725A1 (en) * 2007-08-31 2009-06-04 Abbott Diabetes Care, Inc. Method of Optimizing Efficacy of Therapeutic Agent
CN101808684A (zh) * 2007-09-24 2010-08-18 马林克罗特公司 注射监视器
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
DE102007055636A1 (de) 2007-11-21 2009-05-28 Robert Bosch Gmbh Medikamenten-Dosiervorrichtung zum Verabreichen eines flüssigen Medikaments
DE102007055635A1 (de) * 2007-11-21 2009-05-28 Robert Bosch Gmbh System zum Verabreichen eines flüssigen Medikaments
US7875022B2 (en) 2007-12-12 2011-01-25 Asante Solutions, Inc. Portable infusion pump and media player
JP5461427B2 (ja) 2007-12-17 2014-04-02 ニューワールド ファーマシューティカルズ,エルエルシー 統合的な皮内送達、診断、及び、情報伝達システム
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
DK2229201T3 (da) * 2007-12-31 2012-07-09 Novo Nordisk As Elektronisk monitoreret injektionsanordning
US10188787B2 (en) 2007-12-31 2019-01-29 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US9456955B2 (en) 2007-12-31 2016-10-04 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
US8881774B2 (en) * 2007-12-31 2014-11-11 Deka Research & Development Corp. Apparatus, system and method for fluid delivery
CN114796703A (zh) * 2007-12-31 2022-07-29 德卡产品有限公司 输注泵组件
AU2014277760B2 (en) * 2007-12-31 2017-02-02 Deka Products Limited Partnership Infusion pump assembly
US8900188B2 (en) * 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
US10080704B2 (en) 2007-12-31 2018-09-25 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
WO2009088608A2 (en) * 2008-01-02 2009-07-16 The Regents Of The University Of Michigan Dual drug delivery device
US9063627B2 (en) 2008-01-04 2015-06-23 Tactus Technology, Inc. User interface and methods
US9720501B2 (en) 2008-01-04 2017-08-01 Tactus Technology, Inc. Dynamic tactile interface
US20160187981A1 (en) 2008-01-04 2016-06-30 Tactus Technology, Inc. Manual fluid actuator
US9588683B2 (en) 2008-01-04 2017-03-07 Tactus Technology, Inc. Dynamic tactile interface
US9557915B2 (en) 2008-01-04 2017-01-31 Tactus Technology, Inc. Dynamic tactile interface
US9372565B2 (en) 2008-01-04 2016-06-21 Tactus Technology, Inc. Dynamic tactile interface
US9274612B2 (en) 2008-01-04 2016-03-01 Tactus Technology, Inc. User interface system
US20090177142A1 (en) 2008-01-09 2009-07-09 Smiths Medical Md, Inc Insulin pump with add-on modules
US10201647B2 (en) 2008-01-23 2019-02-12 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
KR102413397B1 (ko) 2008-01-23 2022-06-27 데카 프로덕츠 리미티드 파트너쉽 복수의 유체 라인을 사용하는 의료용 치료 시스템에 사용하기 위한 펌프 카세트 및 방법
US11833281B2 (en) 2008-01-23 2023-12-05 Deka Products Limited Partnership Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US10195330B2 (en) 2008-01-23 2019-02-05 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US20090191067A1 (en) * 2008-01-25 2009-07-30 Phluid,Inc. Two chamber pumps and related methods
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8708961B2 (en) 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
IL190335A0 (en) * 2008-03-20 2009-09-22 Gaia Med Ltd Miniature disposable or partially reusable dosing pumps
EP3659628A1 (en) 2008-04-10 2020-06-03 Abbott Diabetes Care, Inc. Method and system for sterilizing an analyte sensor
US20090281494A1 (en) * 2008-05-06 2009-11-12 Das Stephen D Heat Sterilizable Ambulatory Infusion Devices
US9849238B2 (en) * 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
CN102202719B (zh) * 2008-05-08 2014-11-26 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
EP2276537B1 (en) * 2008-05-14 2018-02-14 Becton, Dickinson and Company Separatable infusion set with cleanable interface and straight line attachment
US8172811B2 (en) 2008-05-15 2012-05-08 Roche Diagnostics Operations, Inc. Drug delivery pump drive using a shaped memory alloy wire
DK2303359T3 (da) 2008-05-29 2020-04-27 Hoffmann La Roche Modulær medicinsk infusionsenhed med midler til identifikation/godkendelse mellem dens komponenter
US20090294277A1 (en) * 2008-05-30 2009-12-03 Abbott Diabetes Care, Inc. Method and system for producing thin film biosensors
US8924159B2 (en) * 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
CA2669521A1 (en) * 2008-06-20 2009-12-20 Gojo Industries, Inc. Diaphragm foam pump
US8876755B2 (en) 2008-07-14 2014-11-04 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US7828792B2 (en) * 2008-07-25 2010-11-09 Medasys Incorporated MRI compatible programmable valve pump
US8056582B2 (en) 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US8301260B2 (en) * 2008-08-13 2012-10-30 Daglow Terry D Method of implanting a medical implant to treat hearing loss in a patient, devices for faciliting implantation of such devices, and medical implants for treating hearing loss
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
EP2328104B1 (en) 2008-08-22 2018-04-25 Liebel-Flarsheim Company LLC Power injector with decay constant functionality
EP2626093B1 (en) * 2008-08-28 2014-02-12 Medingo Ltd. Device for enhanced subcutaneous insulin absorption
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
TW201011954A (en) * 2008-09-15 2010-03-16 Micro Base Technology Corp Conduction wire structure applied to the inner of micro piezoelectric pump
JP6288903B2 (ja) 2008-09-15 2018-03-07 デカ・プロダクツ・リミテッド・パートナーシップ 流体送達のためのシステムおよび方法
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
AU2009293019A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care Inc. Solute concentration measurement device and related methods
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8267892B2 (en) * 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US9510854B2 (en) 2008-10-13 2016-12-06 Boston Scientific Scimed, Inc. Thrombectomy catheter with control box having pressure/vacuum valve for synchronous aspiration and fluid irrigation
WO2010043685A1 (en) * 2008-10-15 2010-04-22 Novo Nordisk Health Care Ag System for reconstitution of a powdered drug
US20100185049A1 (en) * 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
MX2011004817A (es) 2008-11-07 2011-07-28 Insuline Medical Ltd Dispositivo y metodo para suministrar farmacos.
EP2331173A2 (en) * 2008-12-05 2011-06-15 Mallinckrodt Inc. Inductively coupled injector faceplate
US9968733B2 (en) * 2008-12-15 2018-05-15 Medtronic, Inc. Air tolerant implantable piston pump
US9168366B2 (en) 2008-12-19 2015-10-27 Icu Medical, Inc. Medical connector with closeable luer connector
US8679090B2 (en) 2008-12-19 2014-03-25 Icu Medical, Inc. Medical connector with closeable luer connector
US9588684B2 (en) 2009-01-05 2017-03-07 Tactus Technology, Inc. Tactile interface for a computing device
ES2688062T3 (es) 2009-01-12 2018-10-30 Becton, Dickinson And Company Set de infusión y/o bomba de parches que tiene al menos uno de un catéter rígido de permanencia interna con rasgos flexibles y/o una conexión de catéter flexible
US9375529B2 (en) 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
US9572532B2 (en) * 2009-01-23 2017-02-21 Qualcomm Incorporated Button sensor
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
WO2010111505A2 (en) 2009-03-25 2010-09-30 Deka Products Limited Partnership Infusion pump methods and systems
US8497777B2 (en) 2009-04-15 2013-07-30 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
US8483967B2 (en) 2009-04-29 2013-07-09 Abbott Diabetes Care Inc. Method and system for providing real time analyte sensor calibration with retrospective backfill
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US20120209249A1 (en) * 2009-06-19 2012-08-16 Sanofi-Aventis Deutschland Gmbh Injection Arrangement for a Flowable Drug
JP5555863B2 (ja) * 2009-07-01 2014-07-23 並木精密宝石株式会社 振動アクチュエータの構造
EP2453948B1 (en) * 2009-07-15 2015-02-18 DEKA Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
EP3689237B1 (en) 2009-07-23 2021-05-19 Abbott Diabetes Care, Inc. Method of manufacturing and system for continuous analyte measurement
ES2888427T3 (es) 2009-07-23 2022-01-04 Abbott Diabetes Care Inc Gestión en tiempo real de los datos relativos al control fisiológico de los niveles de glucosa
WO2011014562A1 (en) * 2009-07-28 2011-02-03 North Carolina State University Methods and devices for targeted injection of microspheres
EP3284494A1 (en) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Portable infusion pump system
WO2011014851A1 (en) 2009-07-31 2011-02-03 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
JP5758388B2 (ja) * 2009-08-18 2015-08-05 ミニパンプス, エルエルシー 適応制御を有する電解質薬物送達ポンプ
CA2771383A1 (en) * 2009-08-27 2011-03-03 Sanofi-Aventis Deutschland Gmbh Modular injection device with integrated display
ES2952361T3 (es) 2009-08-31 2023-10-31 Abbott Diabetes Care Inc Visualizadores para un dispositivo médico
EP2473098A4 (en) 2009-08-31 2014-04-09 Abbott Diabetes Care Inc ANALYTICAL SIGNAL PROCESSING APPARATUS AND METHOD
US8993331B2 (en) 2009-08-31 2015-03-31 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
CN102473276B (zh) 2009-08-31 2016-04-13 雅培糖尿病护理公司 医疗装置及方法
US10092691B2 (en) 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
WO2011041531A1 (en) 2009-09-30 2011-04-07 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
CN104474605B (zh) * 2009-10-13 2017-12-19 瓦莱里塔斯公司 流体输送装置
MX344098B (es) * 2009-10-13 2016-12-05 Philip Morris Products Sa Dispositivo refrescante de aire.
US9132244B2 (en) 2009-11-04 2015-09-15 Koninklijke Philips N.V. Medication delivery apparatus including a medication metering system
DK2327433T3 (da) 2009-11-26 2012-07-23 Hoffmann La Roche Udefra udløselig kanyleanordning
AU2010325518A1 (en) * 2009-11-30 2012-06-14 F.Hoffmann-La Roche Ag Analyte monitoring and fluid dispensing system
US8377034B2 (en) * 2009-12-04 2013-02-19 Std Med, Inc. Vascular access port
US9717850B2 (en) * 2009-12-16 2017-08-01 Becton, Dickinson And Company Self-injection device
KR101301156B1 (ko) * 2009-12-21 2013-09-03 주식회사 알로텍 일회용 의료 핸드피스의 재사용 확인장치
US8613724B2 (en) 2009-12-31 2013-12-24 DEKA Products Limted Partnership Infusion pump assembly
US8803688B2 (en) * 2010-01-07 2014-08-12 Lisa Halff System and method responsive to an event detected at a glucose monitoring device
US20110163880A1 (en) * 2010-01-07 2011-07-07 Lisa Halff System and method responsive to an alarm event detected at an insulin delivery device
US9636455B2 (en) * 2011-12-21 2017-05-02 Deka Products Limited Partnership System, method, and apparatus for estimating liquid delivery
US9151646B2 (en) 2011-12-21 2015-10-06 Deka Products Limited Partnership System, method, and apparatus for monitoring, regulating, or controlling fluid flow
US10911515B2 (en) 2012-05-24 2021-02-02 Deka Products Limited Partnership System, method, and apparatus for electronic patient care
CA3154661A1 (en) 2010-01-22 2011-07-28 Deka Products Limited Partnership Infusion pump apparatus, method and system
WO2013095459A1 (en) 2011-12-21 2013-06-27 Deka Products Limited Partnership System, method, and apparatus for electronic patient care
WO2011091265A1 (en) * 2010-01-22 2011-07-28 Deka Products Limited Partnership Method and system for shape-memory alloy wire control
JP6150523B2 (ja) 2010-02-05 2017-06-21 デカ・プロダクツ・リミテッド・パートナーシップ 注入ポンプ装置、方法およびシステム
US10238794B2 (en) * 2010-02-05 2019-03-26 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
US9662438B2 (en) 2010-02-05 2017-05-30 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
US11660392B2 (en) 2010-02-05 2023-05-30 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
DE102010009540A1 (de) 2010-02-26 2011-09-01 B. Braun Melsungen Ag System und Verfahren zur Steuerung einer Datenübertragung an und/oder von einer Mehrzahl von medizinischen Geräten
JP5671824B2 (ja) 2010-03-25 2015-02-18 セイコーエプソン株式会社 流体注入システム
BR112012024635A2 (pt) 2010-03-30 2017-08-08 Unomedical As dispositivo médico
US8352089B2 (en) * 2010-03-31 2013-01-08 Fishman Corporation Remotely controlled fluid dispenser
WO2011120587A1 (en) * 2010-04-01 2011-10-06 AlpiMed Sàrl Inductively operated fluid dispensing device
KR20130141344A (ko) 2010-04-19 2013-12-26 택투스 테크놀로지, 아이엔씨. 촉각 인터페이스층의 구동 방법
WO2011133604A1 (en) 2010-04-19 2011-10-27 Tactus Technology User interface system
DK2550058T3 (da) 2010-05-06 2014-06-30 Icu Medical Inc Medicinsk forbindelsesindretning med en lukkelig Luer-forbindelsesanordning
US9737659B2 (en) 2010-05-12 2017-08-22 Bioq Pharma Incorporated Apparatus for dispensing medicinal fluids and method of making same
US9539374B2 (en) 2010-05-12 2017-01-10 Haemonetics Corporation Donated blood collection kit
US20110301539A1 (en) * 2010-06-08 2011-12-08 Rickard Matthew J A Fill and purge system for a drug reservoir
US10711807B2 (en) 2010-06-29 2020-07-14 Coldharbour Marine Limited Gas lift pump apparatus with ultrasonic energy generator and method
US20110319861A1 (en) * 2010-06-29 2011-12-29 Robert Wilk Medical device mechanical pump
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
EP2591385B1 (en) 2010-07-07 2017-10-11 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US8777901B2 (en) 2010-09-24 2014-07-15 Perqflo, Llc Infusion pumps
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
EP2624745A4 (en) 2010-10-07 2018-05-23 Abbott Diabetes Care, Inc. Analyte monitoring devices and methods
EP2627277B1 (en) 2010-10-12 2019-11-20 Smith & Nephew, Inc. Medical device
EP2441958A1 (de) * 2010-10-13 2012-04-18 Fresenius Kabi Deutschland GmbH Pumpenmodul, Pumpenbasismodul und Pumpenssystem
CN103124946B (zh) 2010-10-20 2016-06-29 泰克图斯科技公司 用户接口系统及方法
WO2012054878A2 (en) * 2010-10-21 2012-04-26 Gliders, LLC Delivery systems and method thereof
US8919452B2 (en) 2010-11-08 2014-12-30 Baker Hughes Incorporated Casing spears and related systems and methods
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
US8795234B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Integrated spring-activated ballistic insertion for drug infusion device
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US8784383B2 (en) 2010-11-30 2014-07-22 Becton, Dickinson And Company Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
JP6162047B2 (ja) * 2011-02-02 2017-07-12 ザ チャールズ スターク ドレイパー ラボラトリー インク 薬物送達装置
EP3677295A1 (en) 2011-02-09 2020-07-08 Becton, Dickinson and Company Self-contained torsion spring inserter for drug delivery infusion set
EP2673023B1 (en) 2011-02-09 2019-04-03 Becton, Dickinson and Company Subcutaneous infusion device
US9149613B2 (en) 2011-02-16 2015-10-06 Sequana Medical Ag Apparatus and methods for treating intracorporeal fluid accumulation
US9675327B2 (en) 2011-02-16 2017-06-13 Sequana Medical Ag Apparatus and methods for noninvasive monitoring of cancerous cells
US8753315B2 (en) * 2011-02-17 2014-06-17 Calibra Medical, Inc. Manual basal bolus drug delivery device
US8588903B2 (en) * 2011-02-22 2013-11-19 Omnitek Partners Llc Liquid reserve battery operated emergency medical devices
CA3177983A1 (en) 2011-02-28 2012-11-15 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
ES2885002T3 (es) * 2011-04-05 2021-12-13 Pharmasens Ag Dispositivo fijado por vía dérmica para acceso intravenoso
CN103635214A (zh) * 2011-05-06 2014-03-12 赛诺菲-安万特德国有限公司 阀元件
US9974928B2 (en) 2011-05-10 2018-05-22 Safesharp Technologies Corporation Apparatus for securing a medical clamp to a patient
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection
CA3078889C (en) 2011-05-24 2022-08-30 Deka Products Limited Partnership Hemodialysis system
US8678346B2 (en) * 2011-06-06 2014-03-25 Automatic Switch Company Near-field wireless powered solenoid valve
EP2729148A4 (en) 2011-07-06 2015-04-22 Parkinson S Inst COMPOSITIONS AND METHODS FOR TREATING SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE
WO2013019852A2 (en) 2011-08-01 2013-02-07 Tandem Diabetes Care, Inc. Therapy management system
US9399151B1 (en) * 2011-08-16 2016-07-26 Elkhart Brass Manufacturing Company, Inc. Fire fighting systems and methods
US20130053815A1 (en) * 2011-08-23 2013-02-28 Allergan, Inc. High recovery vial adaptor
EP2753396B1 (en) 2011-09-09 2017-12-27 ICU Medical, Inc. Medical connectors with fluid-resistant mating interfaces
WO2013050277A1 (en) 2011-10-05 2013-04-11 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
DK2771050T3 (da) * 2011-10-27 2020-09-14 Sanofi Aventis Deutschland Komponent af lægemiddeladministrationsanordning og fremgangsmåde til samling
IN2014CN03021A (zh) 2011-10-28 2015-07-03 Deka Products Lp
WO2013066873A1 (en) 2011-10-31 2013-05-10 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
WO2013067359A2 (en) 2011-11-04 2013-05-10 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US20130116556A1 (en) * 2011-11-05 2013-05-09 Custom Medical Applications Neural safety injection system and related methods
ES2720873T3 (es) * 2011-11-07 2019-07-25 Lilly Co Eli Parche medicinal y sistema de inyector
WO2013070794A2 (en) 2011-11-07 2013-05-16 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
WO2013078426A2 (en) 2011-11-25 2013-05-30 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
US9724466B2 (en) 2011-12-21 2017-08-08 Deka Products Limited Partnership Flow meter
KR101657385B1 (ko) * 2011-12-21 2016-09-13 데카 프로덕츠 리미티드 파트너쉽 유체 흐름 제어 장치
US9372486B2 (en) * 2011-12-21 2016-06-21 Deka Products Limited Partnership System, method, and apparatus for monitoring, regulating, or controlling fluid flow
US9746093B2 (en) 2011-12-21 2017-08-29 Deka Products Limited Partnership Flow meter and related system and apparatus
US9746094B2 (en) 2011-12-21 2017-08-29 Deka Products Limited Partnership Flow meter having a background pattern with first and second portions
US10488848B2 (en) 2011-12-21 2019-11-26 Deka Products Limited Partnership System, method, and apparatus for monitoring, regulating, or controlling fluid flow
US9435455B2 (en) 2011-12-21 2016-09-06 Deka Products Limited Partnership System, method, and apparatus for monitoring, regulating, or controlling fluid flow
US10228683B2 (en) 2011-12-21 2019-03-12 Deka Products Limited Partnership System, method, and apparatus for monitoring, regulating, or controlling fluid flow
GB2497954A (en) * 2011-12-22 2013-07-03 Coldharbour Marine Ltd Gas lift pump with a sonic generator
TW201326773A (zh) 2011-12-30 2013-07-01 Ind Tech Res Inst 壓力感測器的電性量測裝置及其方法
US10335545B2 (en) 2012-01-31 2019-07-02 West Pharma. Services IL, Ltd. Time dependent drug delivery apparatus
US8585635B2 (en) 2012-02-15 2013-11-19 Sequana Medical Ag Systems and methods for treating chronic liver failure based on peritoneal dialysis
WO2013134279A1 (en) * 2012-03-05 2013-09-12 Becton, Dickinson And Company Wireless communication for on-body medical devices
CA2865349C (en) * 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US11524151B2 (en) 2012-03-07 2022-12-13 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
WO2013134511A2 (en) * 2012-03-07 2013-09-12 Deka Products Limited Partnership Volumetric measurement device, system and method
WO2013134486A2 (en) 2012-03-07 2013-09-12 Deka Products Limited Partnership Infusion pump assembly
JP2013192852A (ja) * 2012-03-22 2013-09-30 Terumo Corp 薬液投与装置
US9463280B2 (en) 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
US10668213B2 (en) 2012-03-26 2020-06-02 West Pharma. Services IL, Ltd. Motion activated mechanisms for a drug delivery device
EP2830499B8 (en) 2012-03-30 2019-04-03 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith
US9335910B2 (en) 2012-04-23 2016-05-10 Tandem Diabetes Care, Inc. System and method for reduction of inadvertent activation of medical device during manipulation
US9043161B2 (en) * 2012-05-02 2015-05-26 Cps Products, Inc. Modular system and methodology for testing and measurement
DK2844130T3 (da) * 2012-05-03 2023-07-31 Sensible Medical Innovations Ltd Plastre til fastgørelse af elektromagnetiske (em) sonder
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9715327B2 (en) 2012-06-07 2017-07-25 Tandem Diabetes Care, Inc. Preventing inadvertent changes in ambulatory medical devices
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9572931B2 (en) 2012-06-26 2017-02-21 Ambu A/S Device, system and method for self-administration of a treatment fluid
EP3607980A1 (en) * 2012-08-13 2020-02-12 TG Medwise Ltd. Substance delivery device
US10132793B2 (en) 2012-08-30 2018-11-20 Abbott Diabetes Care Inc. Dropout detection in continuous analyte monitoring data during data excursions
WO2014033781A1 (ja) * 2012-08-30 2014-03-06 テルモ株式会社 制御装置、循環装置及び制御方法
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US9405417B2 (en) 2012-09-24 2016-08-02 Tactus Technology, Inc. Dynamic tactile interface and methods
EP2901153A4 (en) 2012-09-26 2016-04-27 Abbott Diabetes Care Inc METHOD AND DEVICE FOR IMPROVING DELAY CORRECTION FUNCTION DURING IN VIVO MEASUREMENT OF ANALYZ CONCENTRATION WITH ANALYZ CONCENTRATION VARIABILITY AND RANGE DATA
AU2013328883B2 (en) 2012-10-12 2018-08-02 Eli Lilly And Company Chemical engines and methods for their use, especially in the injection of highly viscous fluids
US9321581B2 (en) 2012-10-12 2016-04-26 Eli Lilly And Company Process and device for delivery of fluid by chemical reaction
JP2014079325A (ja) * 2012-10-15 2014-05-08 Seiko Epson Corp 流体注入装置
JP2014084753A (ja) * 2012-10-22 2014-05-12 Seiko Epson Corp 流体注入装置
US20140322706A1 (en) * 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP2912432B1 (en) 2012-10-24 2018-07-04 Genmark Diagnostics Inc. Integrated multiplex target analysis
EP2914546B1 (en) * 2012-11-05 2019-07-10 VERO Biotech LLC Dual platform system for the delivery of nitric oxide
US10842931B2 (en) 2012-12-17 2020-11-24 Board Of Regents Of The University Of Texas System System of intravenous fluid/medication delivery that employs signature flow amplitudes of frequencies to facilitate the detection of intravenous infiltration
EP2935088A4 (en) * 2012-12-19 2017-01-04 S.L. Sprizzi Europe Beverage dispenser and related methods
US9759343B2 (en) 2012-12-21 2017-09-12 Deka Products Limited Partnership Flow meter using a dynamic background image
CN112270969A (zh) 2012-12-21 2021-01-26 德卡产品有限公司 用于电子病人护理的系统
SG11201504879SA (en) 2012-12-21 2015-07-30 Deka Products Lp System, method, and apparatus for electronic patient care
DE102012113087A1 (de) 2012-12-24 2014-07-10 B. Braun Melsungen Ag Pumpe für medizinische Zwecke
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
FR3000897B1 (fr) * 2013-01-14 2016-10-28 Feeligreen Dispositif autoregule d'electrostimulation et/ou iontophorese
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
CA3188079A1 (en) 2013-02-05 2014-08-14 Deka Products Limited Partnership Devices, methods and systems for wireless control of medical devices
US9320851B2 (en) 2013-02-07 2016-04-26 Medizinische Universitaet Graz Infusion arrangement and method
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9084620B2 (en) 2013-03-14 2015-07-21 DePuy Synthes Products, Inc. Detection and clearing of occlusions in catheters
AU2014244579A1 (en) 2013-03-14 2015-10-08 Deka Products Limited Partnership Product dispensing system
CN105228522B (zh) 2013-03-14 2018-06-26 萨诺智能公司 用于生物监测的人体上的微传感器
US9737649B2 (en) 2013-03-14 2017-08-22 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
AU2014236701B2 (en) 2013-03-14 2018-07-19 Smith & Nephew Inc. Systems and methods for applying reduced pressure therapy
US20140276379A1 (en) * 2013-03-15 2014-09-18 Medrad, Inc. Intelligent and configurable fluid delivery system and methods for its use
WO2014150905A2 (en) 2013-03-15 2014-09-25 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
US11058811B2 (en) * 2013-03-15 2021-07-13 Bayer Healthcare Llc Intelligent and configurable fluid delivery system and methods for its use
US9421329B2 (en) 2013-03-15 2016-08-23 Tandem Diabetes Care, Inc. Infusion device occlusion detection system
US9603995B2 (en) 2013-03-15 2017-03-28 Tandem Diabetes Care. Inc. Device and method for setting therapeutic parameters for an infusion device
US10322267B2 (en) * 2013-03-15 2019-06-18 Carlos A. Hakim Externally programmable valve assembly
US8920381B2 (en) * 2013-04-12 2014-12-30 Medtronic Minimed, Inc. Infusion set with improved bore configuration
EP2991721B1 (en) * 2013-05-01 2020-03-11 Bayer Healthcare LLC Fluid path set bolus control device
US9889256B2 (en) 2013-05-03 2018-02-13 Medimop Medical Projects Ltd. Sensing a status of an infuser based on sensing motor control and power input
FR3006052B1 (fr) * 2013-05-23 2015-05-01 Air Liquide Sante Services Dispositif et procede de mesure de duree de consommation de gaz dans un batiment hospitalier
CA2912807C (en) * 2013-06-05 2021-03-02 Basf Se Arrangement and method for measuring a delivery volume and a delivery rate of an intermittently operating pump
US9714650B2 (en) 2013-06-11 2017-07-25 Matthew G. Morris, Jr. Pumping system
CN105492813B (zh) 2013-06-11 2018-01-30 流体处理有限责任公司 具有集成内部流量、压力和/或温度测量的组合隔离阀和止回阀
CA2912357C (en) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US9993620B2 (en) * 2013-06-28 2018-06-12 Safesharp Technologies Corporation Catheter anchoring device and method
CA2914977C (en) 2013-07-03 2021-11-02 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US11077965B2 (en) * 2013-07-03 2021-08-03 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
EP3016711B1 (en) 2013-07-03 2021-04-21 DEKA Products Limited Partnership Fluid connector assembly
US10994871B2 (en) * 2013-07-03 2021-05-04 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
KR101476042B1 (ko) 2013-07-09 2014-12-23 김용무 약물주입용 레귤레이터 장치 및 이를 구비한 약물주입장치
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
KR102235689B1 (ko) * 2013-07-30 2021-04-02 삼성전자주식회사 유체 막힘 센싱 장치 및 유체 막힘 센싱 방법.
DK3030286T3 (da) 2013-08-05 2019-11-11 Cam Med Llc Komfortabel patch-pumpe
US10155070B2 (en) 2013-08-13 2018-12-18 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
US9565718B2 (en) 2013-09-10 2017-02-07 Tandem Diabetes Care, Inc. System and method for detecting and transmitting medical device alarm with a smartphone application
JP5995812B2 (ja) * 2013-09-27 2016-09-21 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 治療液注入システム
WO2015056003A2 (en) 2013-10-14 2015-04-23 Coldharbour Marine Limited Apparatus and method
US20150105731A1 (en) * 2013-10-14 2015-04-16 Medtronic Minimed, Inc. Therapeutic Agent Injection Device and Body
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD751690S1 (en) 2013-11-06 2016-03-15 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
USD745661S1 (en) 2013-11-06 2015-12-15 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
USD751689S1 (en) 2013-11-06 2016-03-15 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
USD752209S1 (en) 2013-11-06 2016-03-22 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
USD749206S1 (en) 2013-11-06 2016-02-09 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
RU2678592C1 (ru) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Сухая композиция, содержащая компонент, улучшающий экструзию
EP4250313A3 (en) 2013-12-26 2023-11-22 Tandem Diabetes Care, Inc. Integration of infusion pump with remote electronic device
WO2015100340A1 (en) 2013-12-26 2015-07-02 Tandem Diabetes Care, Inc. Safety processor for wireless control of a drug delivery device
CA2933166C (en) 2013-12-31 2020-10-27 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
US10232111B2 (en) 2013-12-31 2019-03-19 Abbvie Inc. Pump, motor and assembly for beneficial agent delivery
JP2015128480A (ja) * 2014-01-06 2015-07-16 大研医器株式会社 輸液セット及びその駆動を制御する制御装置並びにこれらを備えた薬液送り機能付き輸液セット
WO2015105906A2 (en) * 2014-01-07 2015-07-16 Tactus Technology, Inc. Dynamic tactile interface
DE102014201258A1 (de) * 2014-01-23 2015-07-23 B. Braun Melsungen Ag Verfahren und Vorrichtung zur Kontrolle des Durchflusses durch eine medizinische Infusionsleitung
WO2015132676A2 (en) * 2014-01-27 2015-09-11 Enginuitymed Inc. Fluid delivery control device
CN106132463A (zh) * 2014-02-05 2016-11-16 赛诺菲 用于给送流体的针
WO2015134526A1 (en) 2014-03-03 2015-09-11 Paul Mario Diperna Fluid delivery pump
CN104888288A (zh) * 2014-03-07 2015-09-09 精工爱普生株式会社 液体输送装置
US20150257687A1 (en) 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20170172475A1 (en) * 2014-03-13 2017-06-22 Sano Intelligence, Inc. System for monitoring body chemistry
US10595754B2 (en) 2014-03-13 2020-03-24 Sano Intelligence, Inc. System for monitoring body chemistry
US9610402B2 (en) * 2014-03-24 2017-04-04 Medtronic Minimed, Inc. Transcutaneous conduit insertion mechanism with a living hinge for use with a fluid infusion patch pump device
US9764124B2 (en) 2014-03-31 2017-09-19 Versago Vascular Access, Inc. Vascular access port
US10369345B2 (en) 2014-03-31 2019-08-06 Versago Vascular Access, Inc. Medical access port, systems and methods of use thereof
WO2015153976A1 (en) 2014-04-03 2015-10-08 Versago Vascular Access, Inc. Devices and methods for installation and removal of a needle tip of a needle
US9433427B2 (en) 2014-04-08 2016-09-06 Incuvate, Llc Systems and methods for management of thrombosis
US9248221B2 (en) 2014-04-08 2016-02-02 Incuvate, Llc Aspiration monitoring system and method
JP5896093B1 (ja) * 2014-04-14 2016-03-30 凸版印刷株式会社 注入器具
US10195342B2 (en) 2014-04-24 2019-02-05 Becton, Dickinson And Company Cannula deployment mechanism
US10279106B1 (en) 2014-05-08 2019-05-07 Tandem Diabetes Care, Inc. Insulin patch pump
EP3142546B1 (en) * 2014-05-15 2022-12-28 The Regents of the University of California Multisensor physiological monitoring system
US9883877B2 (en) 2014-05-19 2018-02-06 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
EP3151883A1 (en) 2014-06-03 2017-04-12 Amgen Inc. Devices and methods for assisting a user of a drug delivery device
WO2015188154A1 (en) 2014-06-05 2015-12-10 Deka Products Limited Partnership System for calculating a change in fluid volume in a pumping chamber
US9717435B2 (en) * 2014-06-13 2017-08-01 Physio-Control, Inc. Intravenous line flow sensor for advanced diagnostics and monitoring in emergency medicine
US9662444B2 (en) * 2014-06-19 2017-05-30 Carefusion 303, Inc. Empty infusion supply container annunciator and detection method
WO2016004329A1 (en) 2014-07-03 2016-01-07 Deka Products Limited Partnership Infusion pump assembly
CN106687154B (zh) 2014-07-31 2021-02-09 史密夫和内修有限公司 用于施用减压治疗的系统和方法
AU2015302297B2 (en) * 2014-08-09 2019-04-18 Bioq Pharma Incorporated Apparatus for dispensing medicinal fluids and method of making same
US9669163B2 (en) 2014-08-09 2017-06-06 Bioq Pharma Incorporated Apparatus for dispensing medicinal fluids and method of making same
WO2016025367A1 (en) * 2014-08-11 2016-02-18 Veeco Instruments Inc. Enhanced enclosures for acoustical gas concentration sensing and flow control
US11219413B2 (en) * 2014-08-26 2022-01-11 Dexcom, Inc. Systems and methods for securing a continuous analyte sensor to a host
US11464899B2 (en) 2014-08-28 2022-10-11 Becton, Dickinson And Company Wireless communication for on-body medical devices
US10850028B2 (en) * 2014-09-15 2020-12-01 Sanofi Triggering injection status information display on a mobile device via tapping the housing of a skin-attachable drug injection device
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
US10912875B2 (en) * 2014-10-09 2021-02-09 Fresenius Medical Care Holdings, Inc. Sensing negative pressure with a pressure transducer
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー/エス 止血および創傷治癒に使用するための乾燥組成物
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
KR102337980B1 (ko) * 2014-11-13 2021-12-13 삼성메디슨 주식회사 무선 프로브, 초음파 진단 장치, 및 그 제어방법
JP1531996S (zh) * 2014-11-26 2015-08-24
WO2016100945A1 (en) 2014-12-18 2016-06-23 Versago Vascular Access, Inc. Devices, systems and methods for removal and replacement of a catheter for an implanted access port
EP3233173B1 (en) 2014-12-18 2024-01-31 Versago Vascular Access, Inc. Catheter patency systems and methods
US10799630B2 (en) 2014-12-19 2020-10-13 Amgen Inc. Drug delivery device with proximity sensor
EP3689394A1 (en) * 2014-12-19 2020-08-05 Amgen Inc. Drug delivery device with live button or user interface field
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
WO2016109041A1 (en) 2014-12-30 2016-07-07 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
AU2015374639B2 (en) 2014-12-30 2020-09-10 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
WO2016115464A1 (en) 2015-01-15 2016-07-21 Deka Products Limited Partnership Infusion device system and apparatus
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
EP3556411B1 (en) 2015-02-17 2021-06-30 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
EP3258989B1 (en) 2015-02-18 2020-01-01 Medtronic Minimed, Inc. Ambulatory infusion pump with static and dynamic seals
CN107106765B (zh) 2015-02-20 2020-10-23 泰尔茂株式会社 给药液装置
US9812754B2 (en) 2015-02-27 2017-11-07 Harris Corporation Devices with S-shaped balun segment and related methods
JP6799001B2 (ja) 2015-03-10 2020-12-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 注入装置
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
US9713430B2 (en) * 2015-03-16 2017-07-25 Nuvo Group Ltd. Acoustic sensors for abdominal fetal cardiac activity detection
US9744297B2 (en) 2015-04-10 2017-08-29 Medimop Medical Projects Ltd. Needle cannula position as an input to operational control of an injection device
US20160303318A1 (en) * 2015-04-16 2016-10-20 Flowonix Medical Incorporated Implantable Drug Delivery Device with Flow Measuring Capabilities
FR3035169B1 (fr) * 2015-04-16 2017-05-05 Technip France Dispositif de controle du remplissage d'une conduite en cours de pose dans une etendue d'eau, ensemble et procede associes
US20200030528A1 (en) * 2015-04-16 2020-01-30 Flowonix Medical Incorporated Implantable Drug Delivery Device with Infusate Measuring Capabilities
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
DE102015106678B4 (de) * 2015-04-29 2018-12-13 Bürkert Werke GmbH Dosiervorrichtung und Verfahren zum Betreiben einer Dosiervorrichtung
US10413662B2 (en) * 2015-05-14 2019-09-17 Carefusion 303, Inc. Priming apparatus and method
US9993595B2 (en) 2015-05-18 2018-06-12 Tandem Diabetes Care, Inc. Patch pump cartridge attachment
EP3097933B1 (en) * 2015-05-26 2019-09-04 Roche Diabetes Care GmbH Cartridge and inserter for a medical system
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CN104906655B (zh) * 2015-07-08 2017-09-01 安徽工程大学 一种无泄漏输液软瓶输液排尽条件的建立方法
US10940292B2 (en) 2015-07-08 2021-03-09 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US11553883B2 (en) 2015-07-10 2023-01-17 Abbott Diabetes Care Inc. System, device and method of dynamic glucose profile response to physiological parameters
EP3322460B1 (en) 2015-07-14 2022-09-07 Versago Vascular Access, Inc. Medical access ports and transfer devices
KR101791954B1 (ko) 2015-07-28 2017-11-01 경희대학교 산학협력단 골식립형 투약 임플란트
CN107029317B (zh) * 2015-07-31 2020-07-28 重庆倍加医疗器械有限公司 药物注射器
CN108136113B (zh) * 2015-08-28 2021-03-12 克里斯医疗系统股份有限公司 包括弹簧接触件的流量传感器系统
US10702292B2 (en) 2015-08-28 2020-07-07 Incuvate, Llc Aspiration monitoring system and method
US10561440B2 (en) 2015-09-03 2020-02-18 Vesatek, Llc Systems and methods for manipulating medical devices
US11793543B2 (en) 2015-09-18 2023-10-24 Obvius Robotics, Inc. Device and method for automated insertion of penetrating member
WO2017060899A2 (en) 2015-10-05 2017-04-13 E3D Agricultural Cooperative Association Ltd. Infusion pump device and method for use thereof
US11315681B2 (en) 2015-10-07 2022-04-26 Smith & Nephew, Inc. Reduced pressure therapy device operation and authorization monitoring
US20170100142A1 (en) 2015-10-09 2017-04-13 Incuvate, Llc Systems and methods for management of thrombosis
WO2017062874A1 (en) 2015-10-09 2017-04-13 Deka Products Limited Partnership Fluid pumping and bioreactor system
CN108348679A (zh) 2015-11-20 2018-07-31 先进微流控技术股份公司 微型泵
US10711788B2 (en) 2015-12-17 2020-07-14 Wayne/Scott Fetzer Company Integrated sump pump controller with status notifications
US10226263B2 (en) 2015-12-23 2019-03-12 Incuvate, Llc Aspiration monitoring system and method
US20210093882A1 (en) * 2015-12-24 2021-04-01 Sharp Kabushiki Kaisha Fixation implement
CA3009409A1 (en) 2016-01-05 2017-07-13 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
GB201600232D0 (en) * 2016-01-06 2016-02-17 Vicentra B V Fluid delivery system
GB201600236D0 (en) * 2016-01-06 2016-02-17 Vicentra B V Fluid delivery system
US11103719B2 (en) * 2016-01-11 2021-08-31 Koninklijke Philips N.V. Method and apparatus for non-audible sensing of a defibrillator status indicator
WO2017125817A1 (en) 2016-01-19 2017-07-27 Unomedical A/S Cannula and infusion devices
USD805631S1 (en) 2016-01-21 2017-12-19 Becton, Dickinson And Company Drug delivery device with insertion mechanism button safety
USD829889S1 (en) 2016-01-21 2018-10-02 Becton, Dickinson And Company Wearable drug delivery device with adhesive
USD857191S1 (en) 2016-01-21 2019-08-20 Becton, Dickinson And Company Wearable drug delivery device
USD806232S1 (en) 2016-01-21 2017-12-26 Becton, Dickinson And Company Drug delivery device with insertion mechanism
USD830547S1 (en) 2016-01-21 2018-10-09 Becton, Dickinson And Company Adhesive liner for wearable drug delivery device
USD829894S1 (en) 2016-01-21 2018-10-02 Becton, Dickinson And Company Wearable drug delivery device baseplate
USD830537S1 (en) 2016-01-21 2018-10-09 Becton, Dickinson And Company Wearable drug delivery device with adhesive and liner
SG11201806463SA (en) 2016-01-28 2018-08-30 Deka Products Lp Apparatus for monitoring, regulating, or controlling fluid flow
USD905848S1 (en) 2016-01-28 2020-12-22 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
EP3411097B8 (en) * 2016-02-02 2020-12-30 Medtronic MiniMed, Inc. Hybrid ambulatory infusion pump with contactless power transmission
JP7069023B2 (ja) 2016-02-12 2022-05-17 メドトロニック ミニメド インコーポレイテッド 携行用注入ポンプおよびそれとの使用のためのアセンブリ
CA3014636A1 (en) 2016-02-16 2017-08-31 Deka Products Limited Partnership Infusion set and inserter assembly
PT3420417T (pt) 2016-02-23 2023-05-04 Deka Products Lp Sistema de controlo de dispositivo de mobilidade
US11399995B2 (en) 2016-02-23 2022-08-02 Deka Products Limited Partnership Mobility device
US10926756B2 (en) 2016-02-23 2021-02-23 Deka Products Limited Partnership Mobility device
US10908045B2 (en) 2016-02-23 2021-02-02 Deka Products Limited Partnership Mobility device
ITUB20161064A1 (it) * 2016-02-25 2017-08-25 Ufi Filters Spa Valvola di bypass ad azione ritardata
CN108780332B (zh) * 2016-02-29 2021-10-01 株式会社富士金 流量控制装置
WO2017152036A1 (en) 2016-03-03 2017-09-08 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US20170273623A1 (en) * 2016-03-13 2017-09-28 Keepspring Medical Inc Adjustable and Detachable Cast with Pressure Sensor
JP2016116948A (ja) * 2016-03-28 2016-06-30 セイコーエプソン株式会社 液体注入システム
US10729617B2 (en) * 2016-03-29 2020-08-04 Phipps Innovations, Llc System, apparatus, and method for extending the useful life of medicine
US10118696B1 (en) 2016-03-31 2018-11-06 Steven M. Hoffberg Steerable rotating projectile
US10492805B2 (en) 2016-04-06 2019-12-03 Walk Vascular, Llc Systems and methods for thrombolysis and delivery of an agent
JP6916812B2 (ja) 2016-04-14 2021-08-11 デカ・プロダクツ・リミテッド・パートナーシップ トランスポータのためのユーザ制御デバイス
DK3442624T3 (da) * 2016-04-14 2024-02-12 Sanofi Aventis Deutschland Nåleenhed og lægemiddelfremføringsanordning med en sådan nåleenhed
WO2017196504A1 (en) * 2016-05-10 2017-11-16 Sage Burton H Jr Spring-driven drug delivery device
EP3454917B1 (en) 2016-05-13 2022-04-06 Smith & Nephew, Inc Automatic wound coupling detection in negative pressure wound therapy systems
USD854145S1 (en) 2016-05-25 2019-07-16 Deka Products Limited Partnership Apparatus to control fluid flow through a tube
JP6957525B2 (ja) 2016-06-02 2021-11-02 ウェスト ファーマ サービシーズ イスラエル リミテッド 3つの位置による針の退避
US20170348479A1 (en) 2016-06-03 2017-12-07 Bryan Choate Adhesive system for drug delivery device
RU2736607C2 (ru) 2016-06-07 2020-11-19 Ф. Хоффманн-Ля Рош Аг Блок привода клапана с исполнительным механизмом из сплава с памятью формы
US10603445B2 (en) 2016-06-09 2020-03-31 Becton, Dickinson And Company Needle actuator assembly for drug delivery system
US10792432B2 (en) 2016-06-09 2020-10-06 Becton, Dickinson And Company Drive assembly and spacer for drug delivery system
US10023454B2 (en) * 2016-06-09 2018-07-17 Spacepharma SA Multichannel liquid delivery system
US10751476B2 (en) 2016-06-09 2020-08-25 Becton, Dickinson And Company Actuator assembly for drug delivery system
US10549044B2 (en) 2016-06-09 2020-02-04 Becton, Dickinson And Company Spacer assembly for drug delivery system
ES2960055T3 (es) 2016-06-16 2024-02-29 Smiths Medical Asd Inc Conjuntos y métodos para conjuntos de administración de sistema de bomba de infusión
EP3490635B1 (en) 2016-08-01 2021-11-17 West Pharma. Services Il, Ltd. Partial door closure prevention spring
US10561797B2 (en) 2016-08-14 2020-02-18 Insulet Corporation Drug delivery device with indicator
JP6715384B2 (ja) 2016-08-22 2020-07-01 イーライ リリー アンド カンパニー 安全な薬剤移送システム
JP7071338B2 (ja) * 2016-08-26 2022-05-18 セクアナ メディカル エヌブイ 埋め込み型装置によって生成されたデータを管理及び分析するためのシステム及び方法
US10716922B2 (en) 2016-08-26 2020-07-21 Sequana Medical Nv Implantable fluid management system having clog resistant catheters, and methods of using same
KR101852069B1 (ko) * 2016-08-29 2018-04-25 서강대학교산학협력단 체내 이식형 약물 주입 펌프 및 그 시스템
DE102016217435B4 (de) * 2016-09-13 2018-08-02 Albert-Ludwigs-Universität Freiburg Fluidpumpe und Verfahren zum Betreiben einer Fluidpumpe
USD805190S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805186S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD804019S1 (en) 2016-09-26 2017-11-28 West Pharmaceutical Services, Inc. Injector device
USD805188S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD805187S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
USD804650S1 (en) 2016-09-26 2017-12-05 West Pharmaceutical Services, Inc. Injector device
USD805189S1 (en) 2016-09-26 2017-12-12 West Pharmaceutical Services, Inc. Injector device
US10751478B2 (en) 2016-10-07 2020-08-25 Insulet Corporation Multi-stage delivery system
CA3040503A1 (en) 2016-10-17 2018-04-26 Bayer Healthcare Llc Fluid control valve and manifold
USD805632S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD808011S1 (en) 2016-10-26 2018-01-16 West Pharmaceutical Services, Inc. Injector device
USD878557S1 (en) 2016-10-26 2020-03-17 West Pharmaceutical Services, Inc. Injector device
USD878556S1 (en) 2016-10-26 2020-03-17 West Pharmaceutical Services, Inc. Injector device
USD806863S1 (en) 2016-10-26 2018-01-02 West Pharmaceutical Services, Inc. Injector device
USD805633S1 (en) 2016-10-26 2017-12-19 West Pharmaceutical Services, Inc. Injector device
USD806235S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device
USD878555S1 (en) 2016-10-26 2020-03-17 West Pharmaceutical Services, Inc. Injector device
USD882765S1 (en) 2016-10-26 2020-04-28 West Pharmaceutical Services, Inc. Injector device
USD806234S1 (en) 2016-10-26 2017-12-26 West Pharmaceutical Services, Inc. Injector device
USD807499S1 (en) 2016-10-26 2018-01-09 West Pharmaceutical Services, Inc. Injector device
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
US10780217B2 (en) 2016-11-10 2020-09-22 Insulet Corporation Ratchet drive for on body delivery system
US11422051B2 (en) * 2016-11-18 2022-08-23 Auckland Uniservices Limited Implantable pressure sensor
US11278665B2 (en) 2016-11-22 2022-03-22 Eitan Medical Ltd. Method for delivering a therapeutic substance
CN106652408A (zh) * 2016-11-30 2017-05-10 郑州同心创远生物科技有限公司 一种运用色彩信息于生物监测的系统
EP3338835A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
EP3562677B1 (en) * 2016-12-29 2021-03-31 Stratasys Ltd. Pressure control system for print head
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. 経皮薬剤送達の装置及び方法
WO2018136699A1 (en) 2017-01-19 2018-07-26 Insulet Corporation Cartridge hold-up volume reduction
US20180207352A1 (en) * 2017-01-24 2018-07-26 Epic Medical Pte Ltd Fluid control apparatus
WO2018142975A1 (ja) * 2017-01-31 2018-08-09 株式会社村田製作所 流体制御装置および血圧計
US11925790B2 (en) 2017-02-17 2024-03-12 Eli Lilly And Company Processes and devices for delivery of fluid by chemical reaction
CN106902425B (zh) * 2017-02-27 2019-08-09 宁波光芒新科科技咨询服务有限公司 一种用于儿童打针手臂定位装置
US10695485B2 (en) 2017-03-07 2020-06-30 Insulet Corporation Very high volume user filled drug delivery device
USD872734S1 (en) 2017-03-14 2020-01-14 Insulet Corporation Display screen with a graphical user interface
USD872733S1 (en) 2017-03-14 2020-01-14 Insulet Corporation Display screen with a graphical user interface
KR101811846B1 (ko) 2017-03-15 2017-12-22 김휘화 안전성을 향상시킨 반자동 주사기
KR101822156B1 (ko) 2017-03-15 2018-01-26 김휘화 안전보관이 용이한 반자동 주사기
WO2018175489A1 (en) 2017-03-21 2018-09-27 Abbott Diabetes Care Inc. Methods, devices and system for providing diabetic condition diagnosis and therapy
US11566614B2 (en) * 2017-03-24 2023-01-31 Fresenius Kabi Usa, Llc Fluid flow control and delivery via multiple fluid pumps
US11542936B2 (en) * 2017-03-24 2023-01-03 Fresenius Kabi Usa, Llc Fluid flow control and delivery via multiple fluid pumps
CN110431508A (zh) * 2017-03-28 2019-11-08 株式会社富士金 压力式流量控制裝置以及流量控制方法
WO2018191467A1 (en) * 2017-04-12 2018-10-18 Roche Diabetes Care, Inc. Medical system
EP3615128B1 (en) 2017-04-24 2022-11-09 DEKA Products Limited Partnership Apparatus, system and method for fluid delivery
US10772715B2 (en) * 2017-04-25 2020-09-15 Digirodeo S.A. Injection pistol for animal treatment with identification assistant
JP7169991B2 (ja) 2017-05-05 2022-11-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 自己注射器
USD829612S1 (en) 2017-05-20 2018-10-02 Deka Products Limited Partnership Set of toggles
USD846452S1 (en) 2017-05-20 2019-04-23 Deka Products Limited Partnership Display housing
EP3612246B1 (en) 2017-05-24 2020-12-30 Sequana Medical NV Direct sodium removal method, solution and apparatus to reduce fluid overload in heart failure patients
US11559618B2 (en) 2017-05-24 2023-01-24 Sequana Medical Nv Formulations and methods for direct sodium removal in patients having severe renal dysfunction
CN110691621B (zh) * 2017-05-25 2021-02-09 西部制药服务有限公司 利用感应的柱塞位置检测与通信
CN110869072B (zh) 2017-05-30 2021-12-10 西部制药服务有限公司(以色列) 用于穿戴式注射器的模块化驱动机构
AR108648A1 (es) * 2017-06-01 2018-09-12 Iturriaga Carlos Ignacio Pistola inyectora para tratamiento de animales con contador accionado por empuje incorporado
US10994079B2 (en) 2017-06-15 2021-05-04 Hwi Hwa KIM Semiautomatic syringe with improved safety
USD893552S1 (en) 2017-06-21 2020-08-18 Wayne/Scott Fetzer Company Pump components
AU2018291369A1 (en) * 2017-06-29 2020-02-13 Matthews International Corporation Fluid delivery system and method
CN107243098A (zh) * 2017-07-04 2017-10-13 九江学院 一种检测静脉输液跑针的控制装置及检测方法
CA3067841A1 (en) 2017-07-06 2019-01-10 Quasuras, Inc. Medical pump with flow control
US20230123806A1 (en) 2017-07-07 2023-04-20 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
ES2920853T3 (es) 2017-07-07 2022-08-10 Neuroderm Ltd Dispositivo para la administración subcutánea de medicamentos fluidos
MX2020000667A (es) 2017-07-18 2020-07-29 Becton Dickinson Co Sistema de administración, dispositivo de suministro, y dispositivo de notificación para comunicar el estado de un dispositivo médico.
AU2018302257A1 (en) 2017-07-19 2020-01-30 Smiths Medical Asd, Inc. Housing arrangements for infusion pumps
US11280327B2 (en) 2017-08-03 2022-03-22 Insulet Corporation Micro piston pump
US10973978B2 (en) 2017-08-03 2021-04-13 Insulet Corporation Fluid flow regulation arrangements for drug delivery devices
WO2019046299A1 (en) * 2017-08-31 2019-03-07 Bayer Healthcare Llc FLUID PATH IMPEDANCE ASSESSMENT FOR IMPROVING FLUID DISTRIBUTION PERFORMANCE
US10814062B2 (en) 2017-08-31 2020-10-27 Becton, Dickinson And Company Reservoir with low volume sensor
CA3066780A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid injector system volume compensation system and method
EP3675929A1 (en) 2017-08-31 2020-07-08 Bayer Healthcare LLC Method for dynamic pressure control in a fluid injector system
JP7252143B2 (ja) 2017-08-31 2023-04-04 バイエル・ヘルスケア・エルエルシー 駆動部材の位置及び流体注入器システムの機械的較正のためのシステム及び方法
AU2018326485B2 (en) 2017-08-31 2024-01-04 Bayer Healthcare Llc Injector pressure calibration system and method
CN109470677B (zh) * 2017-09-08 2021-11-05 清华大学 分子检测装置
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements
BR112020007533A2 (pt) 2017-10-16 2020-10-06 Becton, Dickinson And Company conjunto de espaçador para dispositivo de administração de fármacos
US11179509B2 (en) * 2017-10-24 2021-11-23 Andrew Lazar System and method for detecting dialysis needle dislodgment
USD887547S1 (en) 2017-10-25 2020-06-16 Gliders, LLC Liquid dispenser
USD882072S1 (en) 2017-10-25 2020-04-21 Gliders, LLC Liquid dispenser
CN111655310B (zh) * 2017-11-29 2022-07-05 塞伦诺医疗公司 双主动阀流体压力操作的正排量泵
CN111432860B (zh) 2017-12-08 2023-08-08 坦德姆糖尿病护理瑞士有限责任公司 给药装置
CA3085335A1 (en) 2017-12-11 2019-06-20 Deka Products Limited Partnership Infusion pump assembly having a disposable housing assembly and a blowmolded reservoir
US11058815B2 (en) 2017-12-21 2021-07-13 Versago Vascular Access, Inc. Medical access ports, transfer devices and methods of use thereof
JP7402799B2 (ja) 2017-12-22 2023-12-21 ウェスト ファーマ サービシーズ イスラエル リミテッド サイズの異なるカートリッジを利用可能な注射器
EP3501571A1 (en) 2017-12-22 2019-06-26 Gambro Lundia AB Infusion set for measuring vital signals of a patient comprising a compliance element and a reflective element
WO2019133791A1 (en) * 2017-12-28 2019-07-04 Ackler Scott Formulations, systems, and methods for therapeutic treatment
USD890211S1 (en) 2018-01-11 2020-07-14 Wayne/Scott Fetzer Company Pump components
US10751934B2 (en) * 2018-02-01 2020-08-25 Divergent Technologies, Inc. Apparatus and methods for additive manufacturing with variable extruder profiles
USD907193S1 (en) 2018-02-21 2021-01-05 Eli Lilly And Company Secured medication transfer set
US11712637B1 (en) 2018-03-23 2023-08-01 Steven M. Hoffberg Steerable disk or ball
EP3776801A4 (en) 2018-04-10 2021-12-22 Tandem Diabetes Care, Inc. SYSTEM AND METHOD FOR CHARGING BY INDUCTION A MEDICAL DEVICE
US11523972B2 (en) 2018-04-24 2022-12-13 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
CN208224274U (zh) * 2018-04-27 2018-12-11 广州万孚生物技术股份有限公司 一种微流控芯片及具有该微流控芯片的分析仪器
MX2020011866A (es) 2018-05-09 2021-01-20 Ferrosan Medical Devices As Metodo para preparar una composicion hemostatica.
WO2019232077A1 (en) 2018-05-29 2019-12-05 Chrono Therapeutics Inc. Drug delivery methods and systems
US10874803B2 (en) 2018-05-31 2020-12-29 Insulet Corporation Drug cartridge with drive system
WO2019236713A1 (en) 2018-06-05 2019-12-12 Deka Products Limited Partnership Reservoir devices, methods and systems
MX2020013309A (es) 2018-06-05 2021-05-12 Deka Products Lp Dispositivos, métodos y sistemas contenedores de fluido.
EP3801682A1 (en) 2018-06-06 2021-04-14 Insulet Corporation Linear shuttle pump for drug delivery
MX2020013312A (es) 2018-06-07 2021-06-08 Deka Products Lp Sistema y método para la ejecución de servicios públicos distribuidos.
WO2020018642A1 (en) 2018-07-17 2020-01-23 Insulet Corporation Low force valves for drug delivery pumps
US11678905B2 (en) 2018-07-19 2023-06-20 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
US11419978B2 (en) 2018-07-25 2022-08-23 Quasuras, Inc. Subcutaneous access hub with multiple cannula ports
WO2020036858A1 (en) 2018-08-13 2020-02-20 Monumedical, Llc Syringe with multi-stage filling and dispensing
US10973739B2 (en) * 2018-08-23 2021-04-13 ART MEDICAL Ltd. Medical pump
EP3744368A1 (en) 2018-10-05 2020-12-02 Sorrel Medical Ltd. Triggering sequence
CN113164674A (zh) * 2018-10-15 2021-07-23 康尔福盛303公司 泵流动调整系统
GB2578902A (en) * 2018-11-13 2020-06-03 Sofi Health Ltd Medicament dispensing device
WO2020113006A1 (en) * 2018-11-28 2020-06-04 Insulet Corporation Drug delivery shuttle pump system and valve assembly
US10808550B2 (en) * 2018-12-13 2020-10-20 Raytheon Technologies Corporation Fan blade with integral metering device for controlling gas pressure within the fan blade
GB201820927D0 (en) * 2018-12-21 2019-02-06 Smith & Nephew Wound therapy systems and methods with supercapacitors
US11109800B2 (en) 2019-01-04 2021-09-07 Enable Injections, Inc. Medical fluid injection apparatus and method with detachable patch and monitoring
BR112021012996A2 (pt) 2019-01-04 2021-09-14 Enable Injections, Inc. Aparelho de injeção de fluido médico e método com emplastro destacável e monitoramento
CN109675141A (zh) * 2019-01-31 2019-04-26 深圳中科生物医疗电子有限公司 一种传动部位置可调节的输注泵
US20200246603A1 (en) * 2019-01-31 2020-08-06 Becton, Dickinson And Company Catheter flush device, system, and methods
EP3927394A1 (en) 2019-02-22 2021-12-29 DEKA Products Limited Partnership Infusion set and inserter assembly systems and methods
CN109821096B (zh) * 2019-03-01 2021-02-19 浙江师范大学 一种便携式药品推注器
EP3941549A1 (en) 2019-03-19 2022-01-26 DEKA Products Limited Partnership Medical treatment systems, methods, and apparatuses using a plurality of fluid lines
CN113645934A (zh) * 2019-04-04 2021-11-12 凯希特许有限公司 包括用于非流体管理组织治疗的微型泵的服装
CA3141608A1 (en) 2019-05-20 2020-11-26 Unomedical A/S Rotatable infusion device and methods thereof
US20200384192A1 (en) 2019-06-06 2020-12-10 Medtronic Minimed, Inc. Fluid infusion systems
JP2022536843A (ja) * 2019-06-14 2022-08-19 パシフィック・ダイアビーツ・テクノロジーズ・インコーポレイテッド 持続的なグルコースモニタリングのための注入デバイス
JP2022537341A (ja) * 2019-06-17 2022-08-25 バイオリンク インコーポレイテッド 分析物選択センサおよび注入システムの機械的結合
US11587839B2 (en) 2019-06-27 2023-02-21 Analog Devices, Inc. Device with chemical reaction chamber
WO2021012852A1 (en) * 2019-07-19 2021-01-28 Medtrum Technologies Inc. Unilateral-driven medical device with infusion and detection integrated
WO2021021596A1 (en) 2019-07-26 2021-02-04 Deka Products Limited Partnership Apparatus for monitoring, regulating, or controlling fluid flow
USD964563S1 (en) 2019-07-26 2022-09-20 Deka Products Limited Partnership Medical flow clamp
US10914617B1 (en) * 2019-07-29 2021-02-09 Terumo Cardiovascular Systems Corporation Flexible sensor mount for hard shell blood reservoir
US11396417B2 (en) 2019-07-30 2022-07-26 Voyager Products Inc. System and method for dispensing liquids
WO2021022231A1 (en) * 2019-08-01 2021-02-04 The Regents Of The University Of California Active microneedles for enhanced payload uptake
TWI735138B (zh) * 2019-08-02 2021-08-01 華廣生技股份有限公司 生理訊號傳感裝置
US20210069411A1 (en) 2019-09-10 2021-03-11 Deka Products Limited Partnership Medical Device, Method and Systems
US11510497B2 (en) 2019-09-13 2022-11-29 Deka Products Limited Partnership Quick release connector
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump
US20210170094A1 (en) * 2019-12-06 2021-06-10 Quasuras, Inc. Training cartridge for medical pump systems
CN114727783A (zh) 2019-12-23 2022-07-08 费森尤斯医疗保健控股公司 用于促红细胞生成素刺激剂的连接的药物输送系统
WO2022140204A1 (en) * 2020-12-21 2022-06-30 Beta Bionics, Inc. Medicament pumps and control systems thereof
US11642459B2 (en) * 2020-01-15 2023-05-09 Becton, Dickinson And Company System and method for air removal
WO2021150508A1 (en) * 2020-01-20 2021-07-29 Aita Bio Inc. Device for delivering medication with integrated interposer and micropump
US11817197B2 (en) 2020-02-07 2023-11-14 Quasuras, Inc. Medical pump electronic pairing with device
US11278661B2 (en) 2020-03-10 2022-03-22 Beta Bionics, Inc. Infusion system and components thereof
US11305333B2 (en) 2020-03-31 2022-04-19 Insulet Corporation Methods for forming low stress component for medical devices
JP2023521126A (ja) * 2020-04-14 2023-05-23 エスエイチエル・メディカル・アーゲー ニードルを備える、皮膚に対して薬剤送達デバイスを固着するためのパッド
US11712516B2 (en) 2020-04-17 2023-08-01 Analog Devices, Inc. Fluid delivery device
CA3228198A1 (en) 2020-04-30 2021-11-04 Bayer Healthcare Llc System, device, and method for safeguarding wellbeing of patients for fluid injection
US20230173167A1 (en) * 2020-05-12 2023-06-08 Pocket Clinic Tecnologia Da Informaçâo Ltda, Automated drug microinjection pump with wireless communication and method of use
BR112022027121A2 (pt) * 2020-07-02 2023-03-07 Enable Injections Inc Método e aparelho de injeção de fluido médico com patch reutilizável
DK4048152T3 (da) 2020-07-29 2024-03-11 Biolinq Incorporated System til kontinuerlig analytovervågning med mikronålsindretning
AU2021333768A1 (en) * 2020-08-27 2023-04-20 Insulet Corporation Wearable micro-dosing drug delivery device
CN112180075B (zh) * 2020-09-24 2023-04-07 南昌大学第二附属医院 医疗用尿液样本自动化采集设备
WO2022093577A1 (en) * 2020-10-30 2022-05-05 Insulet Corporation Pump device for wearable drug delivery device
CN112494325B (zh) * 2020-11-19 2021-08-24 联赢医疗科技有限公司 一种可自动调配药液的输液机器人
US11241530B1 (en) 2020-11-23 2022-02-08 Amf Medical Sa Insulin patch pump having photoplethysmography module
US20220199218A1 (en) 2020-12-07 2022-06-23 Beta Bionics, Inc. Ambulatory medicament pump with integrated medicament ordering interface
US20220189603A1 (en) 2020-12-07 2022-06-16 Beta Bionics, Inc. Medicament pumps and control systems for managing glucose control therapy data of a subject
US20220265143A1 (en) 2020-12-07 2022-08-25 Beta Bionics, Inc. Ambulatory medicament pumps with selective alarm muting
US11497852B2 (en) 2020-12-21 2022-11-15 Beta Bionics, Inc. Ambulatory medicament device with power saving mode
US20220218897A1 (en) * 2021-01-08 2022-07-14 Insulet Corporation Single actuated precision dose intermediate pumping chamber
US20220226573A1 (en) * 2021-01-18 2022-07-21 Medtronic Minimed, Inc. Infusion device
US11464902B1 (en) * 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
AU2022238533A1 (en) 2021-03-16 2023-10-05 Deka Products Limited Partnership Infusion device assembly
EP4070828A1 (en) * 2021-04-07 2022-10-12 Insulet Corporation Fluid delivery pump valve assembly
US11604084B2 (en) 2021-04-15 2023-03-14 Analog Devices, Inc. Sensor package
USD988882S1 (en) 2021-04-21 2023-06-13 Informed Data Systems Inc. Sensor assembly
US20220339346A1 (en) * 2021-04-23 2022-10-27 Insulet Corporation Dispensing device for wearable drug delivery device
IT202100010589A1 (it) 2021-04-27 2022-10-27 Actuator Solutions GmbH Sottoinsieme fluidico azionato da lega a memoria di forma e apparecchiatura che lo incorpora
US11796367B2 (en) 2021-05-07 2023-10-24 Analog Devices, Inc. Fluid control system
CN116113454A (zh) 2021-05-08 2023-05-12 比奥林股份有限公司 基于微针阵列的连续分析物监测装置的故障检测
US11857757B2 (en) 2021-06-01 2024-01-02 Tandem Diabetes Care Switzerland Sàrl Systems and methods for delivering microdoses of medication
US11541169B2 (en) 2021-06-01 2023-01-03 Amf Medical Sa Applicators for systems and methods for delivering microdoses of medication
US11679199B2 (en) 2021-06-01 2023-06-20 Amf Medical Sa Systems and methods for delivering microdoses of medication
KR20240017396A (ko) * 2021-07-14 2024-02-07 에스에이치엘 메디컬 아게 주사 지지 패드
US20230115397A1 (en) * 2021-08-04 2023-04-13 Cercacor Laboratories, Inc. Medication delivery pump for redundant staggered glucose sensor insulin dosage system
WO2023038778A1 (en) * 2021-08-19 2023-03-16 Innovative Health Strategies Llc A smart self-activating wearable device for automatically injecting medicines
USD1013864S1 (en) 2021-08-26 2024-02-06 Deka Products Limited Partnership Fluid administration apparatus assembly
WO2023028296A1 (en) 2021-08-26 2023-03-02 Deka Products Limited Partnership Infusion set and inserter assembly apparatuses, systems, and methods
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
WO2023141318A1 (en) * 2022-01-24 2023-07-27 Aita Bio Inc. Detachable activation mechanism and cartridge assembly for inserting dual introducer needles
WO2023168419A2 (en) 2022-03-03 2023-09-07 Deka Products Limited Partnership Systems, methods, and apparatuses for medical agent administration
WO2023183018A1 (en) * 2022-03-22 2023-09-28 Jonathan Cole Harding Device and method for controlled dispensing of liquids including alcoholic beverages and medications
WO2023200756A1 (en) * 2022-04-11 2023-10-19 Ag Ip Holding, Llc Pump with evacuated driver for auto-injection
CN114961675B (zh) * 2022-05-25 2023-07-14 德州华海石油机械股份有限公司 智能在线检测注入设备
WO2023241918A1 (en) * 2022-06-14 2023-12-21 Shl Medical Ag Pump drive for a medicament delivery device
US20240009384A1 (en) * 2022-07-08 2024-01-11 Becton, Dickinson And Company System and Method for Detecting Priming of a Fluid Path of a Drug Delivery Device
WO2024019793A1 (en) 2022-07-21 2024-01-25 Deka Products Limited Partnership Delivery device systems, methods, and apparatuses
US20240066217A1 (en) 2022-08-26 2024-02-29 Deka Products Limited Partnership Infusion set and inserter assembly apparatuses, systems, and methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268640A (en) * 1968-05-31 1972-03-29 Nat Res Dev Acoustic detection apparatus
US4273121A (en) * 1978-02-17 1981-06-16 Andros Incorporated Medical infusion system
US5349852A (en) * 1986-03-04 1994-09-27 Deka Products Limited Partnership Pump controller using acoustic spectral analysis
CN1202248A (zh) * 1995-09-25 1998-12-16 施蓝姆伯格工业公司 流体流速的声学测量方法

Family Cites Families (1049)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US248873A (en) 1881-11-01 miles
US254446A (en) 1882-03-07 Cleaner for steam-boilers
US647788A (en) 1899-08-19 1900-04-17 James C Anderson Cycle-cab.
US5338157B1 (en) 1992-09-09 1999-11-02 Sims Deltec Inc Systems and methods for communicating with ambulat
US6241704B1 (en) 1901-11-22 2001-06-05 Sims Deltec, Inc. Drug pump systems and methods
US1922941A (en) * 1930-04-16 1933-08-15 Charles C Francis Apparatus for the automatic administration of medication
US2122722A (en) 1936-07-17 1938-07-05 John A O'neill Insulin bottle holder
US2308974A (en) 1939-11-01 1943-01-19 Lyndus E Harper Positive displacement pump
GB685178A (en) 1950-01-17 1952-12-31 Becton Dickinson Co Improvements relating to hypodermic injection apparatus
US2677372A (en) * 1952-06-13 1954-05-04 Jr Andrew William Barnish Bottle holder
US3075382A (en) * 1958-09-09 1963-01-29 Owens Illinois Glass Co Apparatus for acoustically measuring volume
US3042086A (en) * 1961-01-30 1962-07-03 Chelwin Productions Inc Device for filling blood containers
US3261330A (en) 1962-11-07 1966-07-19 Clayton Manufacturing Co Interlocked water and fuel system for steam cleaners and the like
US3353491A (en) * 1965-09-28 1967-11-21 James W Bastian Pumping device
US3486539A (en) * 1965-09-28 1969-12-30 Jacuzzi Bros Inc Liquid dispensing and metering assembly
US3631847A (en) * 1966-03-04 1972-01-04 James C Hobbs Method and apparatus for injecting fluid into the vascular system
US3447479A (en) * 1967-06-02 1969-06-03 Pall Corp Syringe pump
US3512748A (en) 1967-08-14 1970-05-19 Pacific Plantronics Inc Fluid-flow controller
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3722557A (en) 1971-03-03 1973-03-27 Baxter Laboratories Inc Apparatus for adding medicaments to a sealed expandable parenteral fluid container
US3719213A (en) * 1971-03-03 1973-03-06 Barter Lab Inc Method for adding medicaments to a sealed expandable parenteral fluid container
US3752510A (en) 1971-10-07 1973-08-14 Sherwood Medical Ind Inc Structure for connecting a flexible tube to a syringe
US3762673A (en) * 1971-11-23 1973-10-02 H Koslovsky Medicant withdrawal unit
US3965889A (en) * 1971-11-26 1976-06-29 Commissariat A L'energie Atomique Apparatus for the sampling of blood and the separation of plasma under anaerobic conditions
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3811122A (en) 1972-06-23 1974-05-14 Baker Ind Inc Supervised battery power supply
US3811121A (en) 1972-06-23 1974-05-14 Baker Ind Inc Supervised battery power supply
US3887393A (en) 1972-12-15 1975-06-03 Bell & Howell Co Battery holder assembly
US3833030A (en) 1973-03-05 1974-09-03 E Flippo Device for withdrawing or adding fluids to hypodermic syringes
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US3915171A (en) 1974-06-06 1975-10-28 Dennis William Shermeta Gastrostomy tube
US3963151A (en) 1974-08-05 1976-06-15 Becton, Dickinson And Company Fluid dispensing system
US3965897A (en) * 1974-10-11 1976-06-29 Origo, Incorporated Measured volume drug administration device for use with intravenous feeding pump
US3965946A (en) 1975-03-06 1976-06-29 Abbott Laboratories Vacuum device for an expandable container
US3951147A (en) * 1975-04-07 1976-04-20 Metal Bellows Company Implantable infusate pump
US3986507A (en) * 1975-04-16 1976-10-19 Inpaco Parenteral container
US3990797A (en) 1975-05-27 1976-11-09 Xerox Corporation Diffraction monitoring of Rayleigh mode jets
US4089624A (en) 1976-06-04 1978-05-16 Becton, Dickinson And Company Controlled pumping system
USD248873S (en) 1976-07-01 1978-08-08 Concord Laboratories Blood gas syringe stopper
US4273122A (en) * 1976-11-12 1981-06-16 Whitney Douglass G Self contained powered injection system
US4123631A (en) 1977-02-16 1978-10-31 Owens-Illinois, Inc. Touch switch
US4199307A (en) * 1977-07-05 1980-04-22 Andros Incorporated Medical infusion system
NL7714233A (nl) 1977-12-22 1979-06-26 Philips Nv Batterijhouder.
DE2758368C2 (de) 1977-12-28 1985-10-17 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zur vorprogrammierbaren Infusion von Flüssigkeiten
US4559037A (en) 1977-12-28 1985-12-17 Siemens Aktiengesellschaft Device for the pre-programmable infusion of liquids
DE2758467C2 (de) 1977-12-28 1985-04-04 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zur vorprogrammierbaren Infusion von Flüssigkeiten
US4331262A (en) 1978-04-07 1982-05-25 New Brunswick Scientific Co., Inc. Calibratable automatic fluid dispenser
USD254446S (en) * 1978-04-14 1980-03-11 Concord Laboratories Blood gas syringe stopper
US4215701A (en) 1978-08-21 1980-08-05 Concord Laboratories, Inc. Elastomeric plunger tip for a syringe
DE7831842U1 (de) 1978-10-26 1979-03-08 Braun Ag, 6000 Frankfurt Taschenrechner mit einer Kammer für die Aufnahme von Batterien
SE430377B (sv) 1978-12-06 1983-11-14 Ilon B E Anordning vid gangstod uppvisande ett hjulforsett underrede
US4258711A (en) * 1979-02-05 1981-03-31 Metal Bellows Corporation Infusion apparatus and method
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4265241A (en) 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4525165A (en) 1979-04-27 1985-06-25 The Johns Hopkins University Fluid handling system for medication infusion system
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4731051A (en) 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
US4533346A (en) 1979-06-26 1985-08-06 Pharmacontrol Corporation System for automatic feedback-controlled administration of drugs
US4303376A (en) 1979-07-09 1981-12-01 Baxter Travenol Laboratories, Inc. Flow metering cassette and controller
US4296949A (en) 1979-08-06 1981-10-27 Abbott Laboratories Rotatable connecting device for I.V. administration set
US4278225A (en) 1979-09-04 1981-07-14 Phelps Dennis B Inclined vial holder
DE2938856A1 (de) 1979-09-26 1981-04-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Verfahren und vorrichtung zur ermittlung der ablagerung von partikeln im atemtrakt und/oder zur ueberpruefung der funktion des atemtraktes
US4253501A (en) * 1979-11-09 1981-03-03 Ims Limited Transfer system
US4318400A (en) * 1980-01-18 1982-03-09 Alza Corporation Medical infusor
US4452532A (en) 1980-06-18 1984-06-05 Philip Morris Incorporated Beam alignment tool and method
AU546785B2 (en) 1980-07-23 1985-09-19 Commonwealth Of Australia, The Open-loop controlled infusion of diabetics
US4453931A (en) * 1980-08-01 1984-06-12 Oximetrix, Inc. Intravenous metering device
DE3035670A1 (de) 1980-09-22 1982-04-29 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zur infusion von fluessigkeiten in den menschlichen oder tierischen koerper
US4371594A (en) 1980-10-03 1983-02-01 Canon Kabushiki Kaisha Battery accommodating device
US4398908A (en) * 1980-11-28 1983-08-16 Siposs George G Insulin delivery system
US4396385A (en) * 1980-12-05 1983-08-02 Baxter Travenol Laboratories, Inc. Flow metering apparatus for a fluid infusion system
US4447233A (en) * 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4447234A (en) * 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4468221A (en) * 1981-04-10 1984-08-28 Parker-Hannifin Corporation Medication infusion pump
US4445535A (en) * 1981-04-10 1984-05-01 Parker-Hannifin Corporation Medication infusion pump
JPS57211361A (en) 1981-06-23 1982-12-25 Terumo Corp Liquid injecting apparatus
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4392849A (en) 1981-07-27 1983-07-12 The Cleveland Clinic Foundation Infusion pump controller
US4437859A (en) 1981-08-03 1984-03-20 Drs Infusion Systems, Inc. Hydraulic syringe drive
US4411652A (en) 1981-08-21 1983-10-25 The Regents Of The University Of California Internally sterile pulsatile infusor system
US4391883A (en) 1981-09-28 1983-07-05 Motorola, Inc. Housing arrangement with breakaway battery access door
US4474061A (en) 1981-11-27 1984-10-02 Motorola, Inc. Sonic pressure volume measuring device
US4494950A (en) * 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4453523A (en) 1982-03-08 1984-06-12 Outboard Marine Corporation Pressure balanced flow regulator for gaseous fuel engine
US4498843A (en) 1982-08-02 1985-02-12 Schneider Philip H Insulin infusion pump
US4443218A (en) 1982-09-09 1984-04-17 Infusaid Corporation Programmable implantable infusate pump
US4464170A (en) 1982-09-29 1984-08-07 Miles Laboratories, Inc. Blood glucose control apparatus and method
US4465472A (en) 1982-11-22 1984-08-14 American Hospital Supply Corp. Syringe cartridge and method
US4645489A (en) 1982-11-30 1987-02-24 Beta Phase, Inc. Fluid delivery apparatus with shape-memory flow control element
US4543093A (en) 1982-12-20 1985-09-24 Becton, Dickinson And Company Variable sealing pressure plunger rod assembly
US4486190A (en) 1982-12-27 1984-12-04 Consolidated Controls Corporation Precision medication dispensing system and method
IT1170375B (it) * 1983-04-19 1987-06-03 Giuseppe Bombardieri Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente
SU1131285A1 (ru) 1983-05-18 1995-04-20 Всесоюзный научно-исследовательский институт нефтепромысловой геофизики Пробоотборник для испытателя пластов
IL69431A (en) 1983-08-04 1987-12-31 Omikron Scient Ltd Liquid delivery system particularly useful as an implantable micro-pump for delivering insulin or other drugs
US4790829A (en) * 1983-08-24 1988-12-13 Russell Bowden Reusable injection catheter
US4604090A (en) 1983-11-22 1986-08-05 Consolidated Controls Corporation Compact implantable medication infusion device
US4826810A (en) 1983-12-16 1989-05-02 Aoki Thomas T System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4562751A (en) * 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
CA1257165A (en) 1984-02-08 1989-07-11 Paul Epstein Infusion system having plural fluid input ports and at least one patient output port
US5100380A (en) * 1984-02-08 1992-03-31 Abbott Laboratories Remotely programmable infusion system
US4550731A (en) 1984-03-07 1985-11-05 Cordis Corporation Acquisition circuit for cardiac pacer
US4542532A (en) 1984-03-09 1985-09-17 Medtronic, Inc. Dual-antenna transceiver
GB8408847D0 (en) 1984-04-05 1984-05-16 Ti Group Services Ltd Electrical switches
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
CA1233363A (en) * 1984-06-01 1988-03-01 Robert E. Fischell Single valve diaphragm pump with decreased sensitivity to ambient conditions
EP0168675B1 (en) * 1984-06-21 1990-04-11 David R. Fischell Finger actuated medication infusion system
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4559038A (en) 1984-10-19 1985-12-17 Deltec Systems, Inc. Drug delivery system
US4704902A (en) * 1984-12-04 1987-11-10 Doshi Navin H Acoustical volume/pressure measurement device
US4657490A (en) * 1985-03-27 1987-04-14 Quest Medical, Inc. Infusion pump with disposable cassette
US4838857A (en) 1985-05-29 1989-06-13 Becton, Dickinson And Company Medical infusion device
US4735441A (en) 1985-06-03 1988-04-05 Hewlett-Packard Company Non-loosening luer nut
US4687423A (en) * 1985-06-07 1987-08-18 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
US4626243A (en) * 1985-06-21 1986-12-02 Applied Biomedical Corporation Gravity-independent infusion system
US4690878A (en) 1985-08-23 1987-09-01 Minolta Camera Kabukishi Kaisha Battery power detector for sensing presence of batteries
US5364346A (en) 1985-12-20 1994-11-15 Schrezenmeir Juergen Process for the continuous and discontinuous administration of insulin to the human body
US4714462A (en) * 1986-02-03 1987-12-22 Intermedics Infusaid, Inc. Positive pressure programmable infusion pump
US4741731A (en) 1986-02-19 1988-05-03 Fibra-Sonics, Inc. Vented ultrasonic transducer for surgical handpiece
US4755173A (en) 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US5211201A (en) 1986-03-04 1993-05-18 Deka Products Limited Partnership Intravenous fluid delivery system with air elimination
US5222946A (en) 1986-03-04 1993-06-29 Deka Products Limited Partnership Compact intravenous fluid delivery system
US5088515A (en) * 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US5178182A (en) 1986-03-04 1993-01-12 Deka Products Limited Partnership Valve system with removable fluid interface
US5575310A (en) 1986-03-04 1996-11-19 Deka Products Limited Partnership Flow control system with volume-measuring system using a resonatable mass
US4976162A (en) * 1987-09-03 1990-12-11 Kamen Dean L Enhanced pressure measurement flow control system
US4723947A (en) 1986-04-09 1988-02-09 Pacesetter Infusion, Ltd. Insulin compatible infusion set
US4657138A (en) * 1986-04-11 1987-04-14 Watson Frank K Carrying case for insulin syringes
US4731726A (en) 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
US4803625A (en) 1986-06-30 1989-02-07 Buddy Systems, Inc. Personal health monitor
GB8618578D0 (en) * 1986-07-30 1986-09-10 Turner R C Lancet device
US4790028A (en) 1986-09-12 1988-12-06 Westinghouse Electric Corp. Method and apparatus for generating variably scaled displays
JPH0747045B2 (ja) * 1986-10-15 1995-05-24 株式会社大協精工 積層した注射器用滑栓
IT1214738B (it) * 1986-11-11 1990-01-18 Sbm Soc Brevetti Medicina Perfezionamento negli impianti di stimolazione cardiaca mediante pacemaker
US4796624A (en) 1986-11-19 1989-01-10 Concept, Inc. Lashliner
US4804368A (en) 1986-12-05 1989-02-14 C. R. Bard, Inc. Battery operated miniature syringe infusion pump and improved halfnut therefor
US4747828A (en) 1986-12-09 1988-05-31 Fisher Scientific Group IV fluid line occlusion detector
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4919650A (en) 1987-03-30 1990-04-24 Bionica Pty. Limited Infusion pump
US4811595A (en) 1987-04-06 1989-03-14 Applied Acoustic Research, Inc. System for monitoring fluent material within a container
US5211626A (en) * 1987-05-01 1993-05-18 Product Innovation Holdings Ltd. Medical infusion apparatus
EP0290683A3 (en) 1987-05-01 1988-12-14 Diva Medical Systems B.V. Diabetes management system and apparatus
US5216597A (en) 1987-05-01 1993-06-01 Diva Medical Systems Bv Diabetes therapy management system, apparatus and method
US4938262A (en) * 1987-05-20 1990-07-03 Johnson & Johnson Medical, Inc. Fluid injection system
US4798589A (en) * 1987-06-15 1989-01-17 Fisher Scientific Group Inc. Diaphragm pump cassette
AU609843B2 (en) 1987-06-19 1991-05-09 University Of Melbourne, The Infusion pump
US4976696A (en) 1987-08-10 1990-12-11 Becton, Dickinson And Company Syringe pump and the like for delivering medication
US4809697A (en) 1987-10-14 1989-03-07 Siemens-Pacesetter, Inc. Interactive programming and diagnostic system for use with implantable pacemaker
US4856340A (en) 1987-12-01 1989-08-15 Minimed Technologies Pressure diaphragm for a medication infusion system
US5025374A (en) 1987-12-09 1991-06-18 Arch Development Corp. Portable system for choosing pre-operative patient test
US4898578A (en) * 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US4930494A (en) 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
JPH0534669Y2 (zh) 1988-03-16 1993-09-02
IL86076A (en) 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US4978338A (en) * 1988-04-21 1990-12-18 Therex Corp. Implantable infusion apparatus
GB2218831A (en) 1988-05-17 1989-11-22 Mark John Newland Personal medical apparatus
JP2717808B2 (ja) 1988-08-10 1998-02-25 テルモ株式会社 シリンジポンプ
IE62637B1 (en) * 1988-09-22 1995-02-22 Eolas Irish Science & Tech Apparatus for filling tubes
US4849852A (en) 1988-09-30 1989-07-18 Alps Electric (U.S.A.), Inc. Variable capacitance push-button switch
US5006050A (en) * 1988-12-09 1991-04-09 James E. Cooke High accuracy disposable cassette infusion pump
US5190522A (en) 1989-01-20 1993-03-02 Institute Of Biocybernetics And Biomedical Engineering P.A.S. Device for monitoring the operation of a delivery system and the method of use thereof
US5153827A (en) 1989-01-30 1992-10-06 Omni-Flow, Inc. An infusion management and pumping system having an alarm handling system
US4881063A (en) 1989-01-30 1989-11-14 Ei Company, Ltd. Battery removal indicator
US5425706A (en) 1989-02-24 1995-06-20 S. I. Scientific Innovations Ltd. Dispensing device particularly useful for dispensing nutritional liquids
US5062834A (en) 1989-02-24 1991-11-05 Product Development (S.G.Z.) Ltd Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
US4880712A (en) 1989-03-08 1989-11-14 Motorola, Inc. Battery housing
US4959640A (en) 1989-03-09 1990-09-25 Pioneer Manufacturing, Inc. Apparatus for detect missing battery in smoke detector
JP2733621B2 (ja) 1989-05-03 1998-03-30 日本特殊陶業株式会社 三導体構造フィルタの周波数調整法
DE3915251A1 (de) * 1989-05-10 1990-11-22 Annemarie Schloegl Ges M B H Implantierbare vorrichtung zur dosierten abgabe von medikamenten in den menschlichen koerper
US5103216A (en) 1989-06-12 1992-04-07 Pittway Corporation Improperly inserted battery detector
US5055830A (en) 1989-06-12 1991-10-08 Pittway Corporation Battery sensing mechanism
US5649910A (en) * 1989-06-16 1997-07-22 Science Incorporated Fluid delivery apparatus and method of making same
US5716343A (en) * 1989-06-16 1998-02-10 Science Incorporated Fluid delivery apparatus
DK0404597T3 (da) 1989-06-23 1997-01-06 Rank Taylor Hobson Ltd Metrologisk apparat og fremgangsmåde til kalibrering af samme
GB8914417D0 (en) 1989-06-23 1989-08-09 Rank Taylor Hobson Ltd Interpolator
US5006115A (en) * 1989-07-25 1991-04-09 Medtronic, Inc. Needle placement sensor
US5101814A (en) 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US4972508A (en) 1989-08-28 1990-11-20 Motorola, Inc. Housing for a battery powered device
US5050612A (en) 1989-09-12 1991-09-24 Matsumura Kenneth N Device for computer-assisted monitoring of the body
US5067943A (en) 1989-09-26 1991-11-26 Infusaid, Inc. Pressure regulator for implantable pump
FR2656940A1 (fr) 1990-01-09 1991-07-12 Sgs Thomson Microelectronics Circuit integre a microprocesseur fonctionnant en mode rom interne et eprom externe.
US5104374A (en) 1990-01-16 1992-04-14 Bishko Jay R Electronic fluid flow rate controller for controlling the infusion of intravenous drugs into a patient
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US5254093A (en) 1990-02-12 1993-10-19 Medical Appliances, Inc. Non-reusable hypodermic syringe
US4982769A (en) * 1990-02-21 1991-01-08 Survival Technology, Inc. Package
US5191855A (en) 1990-02-26 1993-03-09 Pittway Corporation Battery missing indicator
US5055001A (en) * 1990-03-15 1991-10-08 Abbott Laboratories Volumetric pump with spring-biased cracking valves
FR2659856B1 (fr) * 1990-03-23 1992-06-05 Asulab Sa Pompe portable d'administration d'une substance therapeutique liquide.
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
US5049141A (en) 1990-04-25 1991-09-17 Infusaid, Inc. Programmable valve pump
US5176502A (en) * 1990-04-25 1993-01-05 Becton, Dickinson And Company Syringe pump and the like for delivering medication
US5078683A (en) 1990-05-04 1992-01-07 Block Medical, Inc. Programmable infusion system
US5270702A (en) 1990-06-04 1993-12-14 Motorola, Inc. Battery door for a selective call receiver
US5174716A (en) 1990-07-23 1992-12-29 General Electric Company Pitch change mechanism
US5176662A (en) 1990-08-23 1993-01-05 Minimed Technologies, Ltd. Subcutaneous injection set with improved cannula mounting arrangement
US5137527A (en) * 1990-09-20 1992-08-11 Clintec Nutrition Co. Enteral-specific spike/bag port system
US5217442A (en) 1990-09-28 1993-06-08 Minimed Technologies Aspiration and refill kit for a medication infusion pump
US5242406A (en) 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
US5090963A (en) 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
US5064080A (en) 1990-11-15 1991-11-12 Plastipak Packaging, Inc. Plastic blow molded freestanding container
WO1992008957A1 (en) 1990-11-19 1992-05-29 Deka Products Limited Partnership Pump controller using acoustic spectral analysis
JPH089891Y2 (ja) 1990-11-27 1996-03-21 リオン株式会社 補聴器の電池収納装置
US5197322A (en) * 1990-11-29 1993-03-30 Minimed Technologies, Ltd. Pressure reservoir filling process for an implantable medication infusion pump
US5056744A (en) 1990-11-29 1991-10-15 Ludwig John G Syringe bottle support apparatus
US5176644A (en) 1990-11-29 1993-01-05 Minimed Technologies, Ltd. Medication infusion pump with improved liquid-vapor pressure reservoir
TW279133B (zh) 1990-12-13 1996-06-21 Elan Med Tech
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5439444A (en) 1991-01-28 1995-08-08 Corpak, Inc. Pre-formed member for percutaneous catheter
US5163909A (en) * 1991-01-28 1992-11-17 Alan E. Jordan Medical fluid delivery system
IL97099A0 (en) 1991-01-30 1992-03-29 Scient Innovations Ltd Infusion pump with safety means controlling the electrolytic cell
US5984894A (en) 1991-04-18 1999-11-16 Novo Nordisk A/S Infuser
US5197895A (en) 1991-05-10 1993-03-30 Bicore Monitoring Systems Disposable electro-fluidic connector with data storage
DE69212069T2 (de) 1991-05-23 1997-02-20 Ivac Corp Antriebssystem für Kolbenstange einer Spritze
US5192511A (en) * 1991-05-31 1993-03-09 Tri-Continent Scientific, Inc. Pipette tip and piston
US5176641A (en) * 1991-07-08 1993-01-05 Infusaid, Inc. Implantable drug infusion reservoir having fluid impelling resilient foam member
US5102388A (en) 1991-07-15 1992-04-07 Richmond John E Sequential delivery syringe
US5207666A (en) * 1991-08-30 1993-05-04 Infusaid, Inc. Passive shuttle metering device for implantable drug delivery system
DE4129271C1 (zh) 1991-09-03 1992-09-17 Fresenius Ag, 6380 Bad Homburg, De
US5356632A (en) 1991-09-12 1994-10-18 S.I. Scientific Innovations Ltd. Transdermal drug delivery device
US5304209A (en) * 1991-09-24 1994-04-19 Angeion Corporation Remote-control temporary pacemaker
US5582793A (en) * 1991-10-03 1996-12-10 Antaeus Group, Inc. Process for treating waste material
US5427737A (en) * 1991-10-03 1995-06-27 Anteus Group, Inc. Process and system for biologically neutralizing waste material
DE4134665A1 (de) 1991-10-19 1993-04-22 Solvay Deutschland Medizinisches inhalationssystem
US5303585A (en) * 1991-10-31 1994-04-19 Jtl Medical Corporation Fluid volume sensor
US5368570A (en) * 1991-11-12 1994-11-29 Imed Corporation Apparatus for infusing medical solutions
US5772637A (en) 1995-06-07 1998-06-30 Deka Products Limited Partnership Intravenous-line flow-control system
US5641892A (en) 1995-06-07 1997-06-24 Deka Products Limited Partnership Intravenous-line air-detection system
US5713865A (en) 1991-11-15 1998-02-03 Deka Products Limited Partnership Intravenous-line air-elimination system
US5755683A (en) * 1995-06-07 1998-05-26 Deka Products Limited Partnership Stopcock valve
US5203506A (en) 1991-12-16 1993-04-20 Product Development (Z.G.S.) Ltd. Liquid pump and nebulizer constructed therewith
US6436078B1 (en) * 1994-12-06 2002-08-20 Pal Svedman Transdermal perfusion of fluids
US6358239B1 (en) * 1992-01-24 2002-03-19 I-Flow Corporation Platen pump
CA2060131C (en) 1992-01-28 1995-06-27 John Mallory Battery socket for smoke detector
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
NL9200207A (nl) 1992-02-05 1993-09-01 Nedap Nv Implanteerbare biomedische sensorinrichting, in het bijzonder voor meting van de glucoseconcentratie.
JPH08275927A (ja) 1992-02-13 1996-10-22 Seta:Kk 在宅医療システム及びこのシステムに用いる医療装置
US5405614A (en) * 1992-04-08 1995-04-11 International Medical Associates, Inc. Electronic transdermal drug delivery system
FR2690622B1 (fr) 1992-04-29 1995-01-20 Chronotec Système de pompe à perfusion ambulatoire programmable.
US5259732A (en) 1992-04-29 1993-11-09 Becton, Dickinson And Company Syringe pump with syringe barrel position detector
US5261884A (en) 1992-04-29 1993-11-16 Becton, Dickinson And Company Syringe pump control system
US5232449A (en) 1992-04-29 1993-08-03 Becton, Dickinson And Company Syringe pump pusher
US5295966A (en) 1992-04-29 1994-03-22 Becton, Dickinson And Company Syringe pump with biased lockable syringe clamp
GB9209362D0 (en) 1992-04-30 1992-06-17 Varitronix Ltd A contact sensitive substrate
US5554013A (en) * 1992-05-01 1996-09-10 Mcgaw, Inc. Disposable cassette with negative head height fluid supply
US5302093A (en) * 1992-05-01 1994-04-12 Mcgaw, Inc. Disposable cassette with negative head height fluid supply and method
US5246147A (en) * 1992-05-20 1993-09-21 Sil Medics Ltd. Liquid material dispenser
US5230614A (en) * 1992-06-03 1993-07-27 Allergan, Inc. Reduced pulsation tapered ramp pump head
WO1993025914A1 (en) * 1992-06-08 1993-12-23 Behring Diagnostics, Inc. Liquid dispensing system
US5543588A (en) 1992-06-08 1996-08-06 Synaptics, Incorporated Touch pad driven handheld computing device
US5314416A (en) 1992-06-22 1994-05-24 Sherwood Medical Company Low friction syring assembly
US5337215A (en) 1992-07-10 1994-08-09 Sherwood Medical Company Pivoting battery compartment and door
IE930532A1 (en) * 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5295599A (en) * 1992-07-20 1994-03-22 Innervision, Inc. Multiple cap seal for containers
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5248569A (en) 1992-07-30 1993-09-28 Motorola, Inc. Battery door having integrated locking mechanism
DE4228958A1 (de) 1992-08-31 1994-03-03 Vorwerk Co Interholding Abstandsgewebe
US5242408A (en) 1992-09-23 1993-09-07 Becton, Dickinson And Company Method and apparatus for determining pressure and detecting occlusions in a syringe pump
US5254096A (en) 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions
US5295967A (en) 1992-09-23 1994-03-22 Becton, Dickinson And Company Syringe pump having continuous pressure monitoring and display
US5569189A (en) * 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5376070A (en) 1992-09-29 1994-12-27 Minimed Inc. Data transfer system for an infusion pump
ATE198159T1 (de) 1992-10-15 2001-01-15 Gen Hospital Corp Infusionspumpe mit elektronisch ladbarer medikamentenbibliothek
US5391157A (en) 1992-10-20 1995-02-21 Eli Lilly And Company End of dose indicator
US5411482A (en) * 1992-11-02 1995-05-02 Infusion Technologies Corporation Valve system and method for control of an infusion pump
US5879163A (en) 1996-06-24 1999-03-09 Health Hero Network, Inc. On-line health education and feedback system using motivational driver profile coding and automated content fulfillment
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US5933136A (en) 1996-12-23 1999-08-03 Health Hero Network, Inc. Network media access control system for encouraging patient compliance with a treatment plan
US5307263A (en) 1992-11-17 1994-04-26 Raya Systems, Inc. Modular microprocessor-based health monitoring system
US5897493A (en) 1997-03-28 1999-04-27 Health Hero Network, Inc. Monitoring system for remotely querying individuals
US5918603A (en) 1994-05-23 1999-07-06 Health Hero Network, Inc. Method for treating medical conditions using a microprocessor-based video game
US5899855A (en) 1992-11-17 1999-05-04 Health Hero Network, Inc. Modular microprocessor-based health monitoring system
US5997476A (en) 1997-03-28 1999-12-07 Health Hero Network, Inc. Networked system for interactive communication and remote monitoring of individuals
US5940801A (en) 1994-04-26 1999-08-17 Health Hero Network, Inc. Modular microprocessor-based diagnostic measurement apparatus and method for psychological conditions
US5913310A (en) 1994-05-23 1999-06-22 Health Hero Network, Inc. Method for diagnosis and treatment of psychological and emotional disorders using a microprocessor-based video game
US5832448A (en) 1996-10-16 1998-11-03 Health Hero Network Multiple patient monitoring system for proactive health management
US6101478A (en) 1997-04-30 2000-08-08 Health Hero Network Multi-user remote health monitoring system
US5960403A (en) 1992-11-17 1999-09-28 Health Hero Network Health management process control system
CA2083555A1 (en) * 1992-11-23 1994-05-24 David H. Laing Portable infusion device
ATE164315T1 (de) * 1992-12-15 1998-04-15 Sanofi Sa Vorrichtung zur vorbereitung einer lösung, einer suspension oder einer emulsion einer medizinischen lösung
DE4300880C2 (de) 1993-01-15 1996-03-21 Draegerwerk Ag Ultraschallvernebler mit Dosiereinheit
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5357427A (en) 1993-03-15 1994-10-18 Digital Equipment Corporation Remote monitoring of high-risk patients using artificial intelligence
US5433710A (en) 1993-03-16 1995-07-18 Minimed, Inc. Medication infusion pump with fluoropolymer valve seat
US5257971A (en) 1993-03-16 1993-11-02 Minimed Technologies, Ltd. Recondition process for a medication infusion pump
US5426602A (en) 1993-03-31 1995-06-20 Mentor Graphics Corporation Detection of multiple hits within a device having multiple sense outputs
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5257980A (en) 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5350411A (en) 1993-06-28 1994-09-27 Medtronic, Inc. Pacemaker telemetry system
US5678568A (en) 1993-07-27 1997-10-21 Olympus Optical Co., Ltd. System control apparatus, medical system control apparatus and image-plane display method of medical system control apparatus
JP3298250B2 (ja) 1993-07-30 2002-07-02 ソニー株式会社 自動検査方法及び自動検査装置
US5368562A (en) 1993-07-30 1994-11-29 Pharmacia Deltec, Inc. Systems and methods for operating ambulatory medical devices such as drug delivery devices
US5312364A (en) * 1993-08-06 1994-05-17 Pyng Intraosseous infusion device
RU2149028C1 (ru) * 1993-08-11 2000-05-20 Томас Джон Берригэн Имплантируемая система для доставки лекарств (варианты)
US5462881A (en) * 1993-08-23 1995-10-31 Brandeis University Temporary liquid storage cavities in a centrifuge tube
DE4329229A1 (de) 1993-08-25 1995-03-09 Meditech Medizintechnik Gmbh Adaptive kontrollierte Pumpensteuerung, insbesondere zur Adaptiven Patientenkontrollierten Analgesie (APCA)
WO1995007066A1 (fr) * 1993-09-07 1995-03-16 Debiotech S.A. Dispositif de seringue pour le melange de deux composes
US5380173A (en) * 1993-09-20 1995-01-10 Cole-Parmer Instrument Company Peristaltic pump
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5399823A (en) * 1993-11-10 1995-03-21 Minimed Inc. Membrane dome switch with tactile feel regulator shim
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5497772A (en) * 1993-11-19 1996-03-12 Alfred E. Mann Foundation For Scientific Research Glucose monitoring system
DE4422710C1 (de) 1994-06-29 1995-09-14 Boehringer Ingelheim Kg Inhalationsgerät mit einem Elektronikmodul zur Funktionsüberwachung
US5660176A (en) 1993-12-29 1997-08-26 First Opinion Corporation Computerized medical diagnostic and treatment advice system
US5594638A (en) 1993-12-29 1997-01-14 First Opinion Corporation Computerized medical diagnostic system including re-enter function and sensitivity factors
DE69508629T2 (de) 1994-01-25 1999-10-14 Becton Dickinson Co Spritze und Verfahren zur Lyophilisierung und Wiederherstellung von einspritzbaren Medikamenten
US5429605A (en) 1994-01-26 1995-07-04 Target Therapeutics, Inc. Microballoon catheter
FR2715780B1 (fr) * 1994-02-01 1996-04-05 Imra Europe Sa Stator de moteur rotatif piézoélectrique et moteur rotatif piézoélectrique comportant un tel stator.
ATE165739T1 (de) * 1994-02-14 1998-05-15 Sanofi Sa Injektionsmodul für eine spritze
US5795337A (en) 1994-02-14 1998-08-18 Becton Dickinson And Company Syringe assembly and syringe stopper
FR2716286A1 (fr) 1994-02-16 1995-08-18 Debiotech Sa Installation de surveillance à distance d'équipements commandables.
US5482438A (en) 1994-03-09 1996-01-09 Anderson; Robert L. Magnetic detent and position detector for fluid pump motor
US5630710A (en) 1994-03-09 1997-05-20 Baxter International Inc. Ambulatory infusion pump
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5482446A (en) 1994-03-09 1996-01-09 Baxter International Inc. Ambulatory infusion pump
US5478211A (en) 1994-03-09 1995-12-26 Baxter International Inc. Ambulatory infusion pump
US5658133A (en) * 1994-03-09 1997-08-19 Baxter International Inc. Pump chamber back pressure dissipation apparatus and method
US5390671A (en) 1994-03-15 1995-02-21 Minimed Inc. Transcutaneous sensor insertion set
EP0672427A1 (en) 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
US5456940A (en) 1994-03-28 1995-10-10 Minimed Inc. System for lubricating a syringe barrel
US5971931A (en) * 1994-03-29 1999-10-26 Raff; Gilbert Lewis Biologic micromonitoring methods and systems
US5527307A (en) 1994-04-01 1996-06-18 Minimed Inc. Implantable medication infusion pump with discharge side port
US5505713A (en) 1994-04-01 1996-04-09 Minimed Inc. Indwelling catheter with stable enzyme coating
US5609575A (en) * 1994-04-11 1997-03-11 Graseby Medical Limited Infusion pump and method with dose-rate calculation
US7033339B1 (en) 1998-05-29 2006-04-25 Becton Dickinson And Company (Part Interest) Self sealing luer receiving stopcock
US5569186A (en) 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
US5370622A (en) 1994-04-28 1994-12-06 Minimed Inc. Proctective case for a medication infusion pump
US5476460A (en) 1994-04-29 1995-12-19 Minimed Inc. Implantable infusion port with reduced internal volume
US5411488A (en) * 1994-05-06 1995-05-02 Sterling Winthrop Inc. Pre-filled syringe and pre-filled cartridge having an improved plunger and plunger rod for reducing syringing force
DE69531292T2 (de) 1994-05-13 2004-05-13 Abbott Laboratories, Abbott Park Einweginfusionskassette mit einem druckknopfbetätigten apsperrventil
US5487728A (en) * 1994-05-19 1996-01-30 Vaillancourt; Vincent L. Connector assembly
US5704366A (en) 1994-05-23 1998-01-06 Enact Health Management Systems System for monitoring and reporting medical measurements
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5472317A (en) 1994-06-03 1995-12-05 Minimed Inc. Mounting clip for a medication infusion pump
US5769608A (en) * 1994-06-10 1998-06-23 P.D. Coop, Inc. Resonant system to pump liquids, measure volume, and detect bubbles
US5533381A (en) 1994-06-10 1996-07-09 Seale; Joseph B. Conversion of liquid volume, density, and viscosity to frequency signals
US5462525A (en) 1994-06-14 1995-10-31 Minimed, Inc., A Delaware Corporation Flow sensor for an infusion pump
US5514103A (en) 1994-06-14 1996-05-07 Minimed Inc. Medication infusion pump with improved pressure reservoir
US5460618A (en) 1994-06-20 1995-10-24 Minimed Inc. Side slit catheter
SE9402237D0 (sv) 1994-06-23 1994-06-23 Astra Ab Measurement methods and systems
US6321158B1 (en) 1994-06-24 2001-11-20 Delorme Publishing Company Integrated routing/mapping information
US5466133A (en) * 1994-06-30 1995-11-14 Tuck, Jr.; Alan D. Peristaltic pump and diaphragm therefor
US5515445A (en) * 1994-06-30 1996-05-07 At&T Corp. Long-time balancing of omni microphones
US5582593A (en) 1994-07-21 1996-12-10 Hultman; Barry W. Ambulatory medication delivery system
US5569187A (en) 1994-08-16 1996-10-29 Texas Instruments Incorporated Method and apparatus for wireless chemical supplying
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
US5505709A (en) 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
DE4432991C1 (de) * 1994-09-16 1995-10-26 Fresenius Ag Implantierbare Infusionspumpe
US5840026A (en) 1994-09-21 1998-11-24 Medrad, Inc. Patient specific dosing contrast delivery systems and methods
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5687734A (en) 1994-10-20 1997-11-18 Hewlett-Packard Company Flexible patient monitoring system featuring a multiport transmitter
GB9421687D0 (en) 1994-10-27 1994-12-14 Aid Medic Ltd Dosimetric spacer
US5545152A (en) 1994-10-28 1996-08-13 Minimed Inc. Quick-connect coupling for a medication infusion system
AUPM922394A0 (en) 1994-11-03 1994-11-24 Astra Pharmaceuticals Pty Ltd Plastic syringe with overcap
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6749586B2 (en) 1994-11-25 2004-06-15 I-Flow Corporation Remotely programmable infusion system
US5573506A (en) 1994-11-25 1996-11-12 Block Medical, Inc. Remotely programmable infusion system
US5660529A (en) 1994-12-06 1997-08-26 Mcgaw, Inc. Linear peristaltic pump with reshaping fingers interdigitated with pumping elements
DE19500154C1 (de) 1995-01-04 1996-10-17 Fritz Giebler Gmbh Infusionsschlauch für ein Infusionsgerät mit einem Blasendetektor
US5685844A (en) 1995-01-06 1997-11-11 Abbott Laboratories Medicinal fluid pump having multiple stored protocols
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
GB9501218D0 (en) 1995-01-21 1995-03-15 Boc Group Plc Medical devices
IT1275135B (it) * 1995-02-06 1997-07-30 Dideco Spa Apparecchio di pompaggio pulsatile per liquidi, in particolare sangue.
US5814015A (en) 1995-02-24 1998-09-29 Harvard Clinical Technology, Inc. Infusion pump for at least one syringe
US5647853A (en) 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5620312A (en) 1995-03-06 1997-04-15 Sabratek Corporation Infusion pump with dual-latching mechanism
US5487738A (en) * 1995-03-31 1996-01-30 Sciulli; Eugene B. Apparatus for drawing fluids into a hypodermic syringe
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US5569188A (en) * 1995-04-11 1996-10-29 Mackool; Richard J. Apparatus for controlling fluid flow through a surgical instrument and the temperature of an ultrasonic instrument
US6099502A (en) 1995-04-20 2000-08-08 Acist Medical Systems, Inc. Dual port syringe
US5609060A (en) 1995-04-28 1997-03-11 Dentsleeve Pty Limited Multiple channel perfused manometry apparatus and a method of operation of such a device
US5721382A (en) * 1995-05-01 1998-02-24 Kriesel; Marshall S. Apparatus for indicating fluid pressure within a conduit
US6293159B1 (en) 1995-05-01 2001-09-25 Science Incorporated Fluid delivery apparatus with reservoir fill assembly
US6391006B1 (en) * 1995-05-01 2002-05-21 Science Incorporated Fluid delivery apparatus with reservoir fill assembly
RU2111018C1 (ru) 1995-05-06 1998-05-20 Центральный научно-исследовательский институт точного машиностроения Аппарат перистальтического действия с системой плавной подачи лекарств
EP1433417B1 (en) * 1995-05-12 2007-12-05 Seiko Epson Corporation Device for controlling a physiological state
US5772635A (en) 1995-05-15 1998-06-30 Alaris Medical Systems, Inc. Automated infusion system with dose rate calculator
US5665065A (en) 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
US5788673A (en) 1995-06-05 1998-08-04 Atrion Medical Products, Inc. Drug infusion system
US6165154A (en) * 1995-06-07 2000-12-26 Deka Products Limited Partnership Cassette for intravenous-line flow-control system
US5733673A (en) 1995-06-07 1998-03-31 Norand Corporation Method and apparatus to detect imminent battery removal in a portable electronic device
US5584813A (en) 1995-06-07 1996-12-17 Minimed Inc. Subcutaneous injection set
US6018289A (en) 1995-06-15 2000-01-25 Sekura; Ronald D. Prescription compliance device and method of using device
EP0833874A1 (en) 1995-06-21 1998-04-08 Minnesota Mining And Manufacturing Company Adhesive compositions, bonding films made therefrom and processes for making bonding films
US5752976A (en) * 1995-06-23 1998-05-19 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US6083248A (en) 1995-06-23 2000-07-04 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5651775A (en) 1995-07-12 1997-07-29 Walker; Richard Bradley Medication delivery and monitoring system and methods
KR100373772B1 (ko) * 1995-07-31 2003-09-13 심영택 발기부전증치료장치
US5720771A (en) * 1995-08-02 1998-02-24 Pacesetter, Inc. Method and apparatus for monitoring physiological data from an implantable medical device
US5607418A (en) * 1995-08-22 1997-03-04 Illinois Institute Of Technology Implantable drug delivery apparatus
US5637420A (en) 1995-09-01 1997-06-10 Globe-Union Inc. Self-latching handle for storage batteries
AU7093096A (en) 1995-09-05 1997-03-27 Elan Medical Technologies Limited Chemically driven liquid delivery pumping device
KR100197580B1 (ko) 1995-09-13 1999-06-15 이민화 무선 통신망을 이용한 실시간 생체신호모니터링시스템
US6277095B1 (en) * 1995-10-11 2001-08-21 Science Incorporated Fluid delivery device with full adapter
CA2190901A1 (en) 1995-11-24 1997-05-25 John B. Shaw Electro-convulsive therapy (ect) system with enhanced safety features
ZA9610374B (en) * 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
AUPN707195A0 (en) 1995-12-12 1996-01-11 University Of Melbourne, The Field programmable intravenous infusion system
US5700257A (en) * 1995-12-19 1997-12-23 Abbott Laboratories Ambulatory IV pump transport apparatus
US5830187A (en) * 1995-12-22 1998-11-03 Science Incorporated Fluid delivery device with conformable ullage and fill assembly
JPH09192218A (ja) * 1996-01-16 1997-07-29 Hitachi Ltd 血糖値管理システム
JPH09197531A (ja) 1996-01-24 1997-07-31 Nikon Corp 撮影レンズ、カメラボディ及びカメラシステム
FI118509B (fi) 1996-02-12 2007-12-14 Nokia Oyj Menetelmä ja laitteisto potilaan veren glukoosipitoisuuden ennustamiseksi
US5575631A (en) * 1996-03-12 1996-11-19 Ahmad-Maher Moubayed Curvilinear peristaltic pump
US5795061A (en) * 1996-03-19 1998-08-18 Brandeis University Vortex mixing implement for sample vessels
US5669887A (en) 1996-04-22 1997-09-23 Cooper; William L. Retractable non-reusable needle
AU2808697A (en) 1996-04-24 1997-11-12 Logitech, Inc. Touch and pressure sensing method and apparatus
FR2748588B1 (fr) 1996-05-07 1998-08-07 Soc Et Tech Set Dispositif comportant au moins un reseau de neurones pour determiner la quantite d'une substance a administrer a un patient, notamment de l'insuline
US5861018A (en) 1996-05-28 1999-01-19 Telecom Medical Inc. Ultrasound transdermal communication system and method
FR2749169B1 (fr) * 1996-06-04 1998-08-21 Delab Procede pour constituer une preparation injectable et dispositif pour la mise en oeuvre de ce procede
US5716725A (en) 1996-06-06 1998-02-10 Motorola, Inc. Method apparatus for indicating improper coupling of a power source to an electronic device
IE80772B1 (en) 1996-06-10 1999-02-10 Elan Corp Plc Delivery needle
WO1997047342A2 (en) 1996-06-10 1997-12-18 Elan Corporation Plc. Needle for subcutaneous delivery of fluids
US5713857A (en) 1996-06-28 1998-02-03 Becton Dickinson France, S.A. Sequential stopper
KR100210224B1 (ko) * 1996-07-03 1999-07-15 김성철 다이어프램 펌프
DE19627619A1 (de) * 1996-07-09 1998-01-15 Orlita Prozesstechnik Orlita G Antrieb für eine Membran- oder Kolbenpumpe für die Dosierung von Medien
US5807336A (en) 1996-08-02 1998-09-15 Sabratek Corporation Apparatus for monitoring and/or controlling a medical device
US6689091B2 (en) 1996-08-02 2004-02-10 Tuan Bui Medical apparatus with remote control
US5885245A (en) 1996-08-02 1999-03-23 Sabratek Corporation Medical apparatus with remote virtual input device
DE69611869T2 (de) 1996-08-26 2001-09-13 Fluidsense Corp Dynamischer Fluid-Durchflussregler mit veränderbaren Impulsen
DE122009000079I2 (de) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
US5824881A (en) * 1996-09-13 1998-10-20 Cobe Laboratories Gas/fluid detector for contained fluid systems
US5800387A (en) 1996-10-04 1998-09-01 Alaris Medical Systems, Inc. Safety monitoring apparatus for a patient care system
WO1998020342A1 (en) * 1996-11-01 1998-05-14 Bp Oil International Limited Testing device and method of use
AU5252998A (en) 1996-11-08 1998-05-29 Linda L. Roman System for providing comprehensive health care and support
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
WO1998024358A2 (en) 1996-12-04 1998-06-11 Enact Health Management Systems System for downloading and reporting medical information
US8734339B2 (en) * 1996-12-16 2014-05-27 Ip Holdings, Inc. Electronic skin patch for real time monitoring of cardiac activity and personal health management
US6176845B1 (en) * 1996-12-18 2001-01-23 Science Incorporated Fluid delivery apparatus with flow indicator and vial fill
US5840071A (en) * 1996-12-18 1998-11-24 Science Incorporated Fluid delivery apparatus with flow indicator and vial fill
JP3025652B2 (ja) 1996-12-20 2000-03-27 芳記 高柳 眼内用バルーン及びこれに用いる挿入ガイド、担持部材
IE960927A1 (en) 1996-12-31 1998-07-01 Elan Med Tech A device for generating a pulsatile fluid drug flow
US6032119A (en) 1997-01-16 2000-02-29 Health Hero Network, Inc. Personalized display of health information
ES2124186B1 (es) 1997-01-20 1999-08-01 Carpe Diem Salud S L Apartado y sistema de control telematico de parametros fisiologicos de pacientes.
JP2001511033A (ja) 1997-02-04 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 液状薬剤懸濁液の投与装置
US6607509B2 (en) 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US5851197A (en) 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
US6093172A (en) 1997-02-05 2000-07-25 Minimed Inc. Injector for a subcutaneous insertion set
US5885270A (en) * 1997-02-05 1999-03-23 Smith Kline Beecham Corporation Method and apparatus for automatically transferring liquids between containers
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5785681A (en) 1997-02-25 1998-07-28 Minimed Inc. Flow rate controller for a medication infusion pump
US6009339A (en) 1997-02-27 1999-12-28 Terumo Cardiovascular Systems Corporation Blood parameter measurement device
US6325756B1 (en) 1997-03-27 2001-12-04 Medtronic, Inc. Concepts to implement medconnect
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US6073036A (en) 1997-04-28 2000-06-06 Nokia Mobile Phones Limited Mobile station with touch input having automatic symbol magnification function
US5851692A (en) 1997-05-01 1998-12-22 Motorola, Inc. Electronic device having a concealed battery latch door
US6530900B1 (en) * 1997-05-06 2003-03-11 Elan Pharma International Limited Drug delivery device
US6186982B1 (en) * 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
US5779665A (en) 1997-05-08 1998-07-14 Minimed Inc. Transdermal introducer assembly
JP3387775B2 (ja) 1997-05-22 2003-03-17 株式会社大協精工 注射器用密封栓及びプレフィルド注射器
US5927351A (en) 1997-05-30 1999-07-27 Syncor International Corp. Drawing station system for radioactive material
US6558351B1 (en) 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US5882256A (en) 1997-06-09 1999-03-16 Shropshire; Maurice C. Fragrance dispenser
US5957890A (en) 1997-06-09 1999-09-28 Minimed Inc. Constant flow medication infusion pump
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US5894870A (en) * 1997-06-10 1999-04-20 Pharmacia & Upjohn Company Syringe guide and vial holder
CA2294610A1 (en) 1997-06-16 1998-12-23 George Moshe Katz Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods
AU8165498A (en) 1997-06-23 1999-01-04 Enact Health Management Systems Improved system for downloading and reporting medical information
JPH1119210A (ja) * 1997-07-09 1999-01-26 Terumo Corp 薬液注入システム及びその可読メモリ
US6033421A (en) 1997-07-11 2000-03-07 Scott Marsh Theiss Tattoo machine
US6484012B1 (en) * 1997-08-04 2002-11-19 Wireless Facilities, Inc. Inter-band communication repeater system
US6368080B1 (en) * 1997-08-04 2002-04-09 Anatole J. Sipin Continuous fluid injection pump
US6130620A (en) 1997-08-11 2000-10-10 Electronic Monitoring Systems, Inc. Remote monitoring system
AU8826498A (en) 1997-08-22 1999-03-16 Apex Inc. Remote computer control system
AU9028498A (en) * 1997-08-22 1999-03-16 Deka Products Limited Partnership System, method and cassette for mixing and delivering intravenous drugs
US6183444B1 (en) 1998-05-16 2001-02-06 Microheart, Inc. Drug delivery module
US5961472A (en) * 1997-09-26 1999-10-05 Baxter International Inc. Closed, one-handed blood sampling system
US5855509A (en) 1997-10-09 1999-01-05 White; William H. Paint spray booth and air supply arrangement
NZ504021A (en) 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
US5973623A (en) 1997-10-21 1999-10-26 Stmicroelectronics, Inc. Solid state capacitive switch
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
NZ504063A (en) 1997-10-23 2003-02-28 Bristol Myers Squibb Co Preloadable syringe with push rod disengable from piston once syringe is loaded
FI107080B (fi) 1997-10-27 2001-05-31 Nokia Mobile Phones Ltd Mittauslaite
US5931791A (en) 1997-11-05 1999-08-03 Instromedix, Inc. Medical patient vital signs-monitoring apparatus
CA2312919C (en) 1997-12-31 2004-12-14 Minimed, Inc. Insertion device for an insertion set and method of using the same
US6110152A (en) 1998-01-13 2000-08-29 Minimed Inc. Medication cartridge for an electronic pen-type injector, infusion pump, electronic delivery device, or the like, and method of making the same
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
US20060287783A1 (en) 1998-01-15 2006-12-21 Kline & Walker Llc Automated accounting system that values, controls, records and bills the uses of equipment/vehicles for society
US20030221118A1 (en) 1998-01-15 2003-11-27 Kline & Walker, Llc Automated accounting system that values, controls, records and bills the uses of equipment/vehicles for society
US7663607B2 (en) 2004-05-06 2010-02-16 Apple Inc. Multipoint touchscreen
US8479122B2 (en) 2004-07-30 2013-07-02 Apple Inc. Gestures for touch sensitive input devices
US5997503A (en) 1998-02-12 1999-12-07 Ballard Medical Products Catheter with distally distending balloon
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6681946B1 (en) * 1998-02-26 2004-01-27 Becton, Dickinson And Company Resealable medical transfer set
US5954697A (en) 1998-03-02 1999-09-21 Srisathapat; Chad Threaded nut syringe plunger for use with a medication infusion pump
US6056718A (en) 1998-03-04 2000-05-02 Minimed Inc. Medication infusion set
CA2325004A1 (en) * 1998-03-23 1999-09-30 Ehoud Carmel Drug delivery device
US6311868B1 (en) 1998-04-06 2001-11-06 New Sensations, L.L.C. Dispenser which incrementally heats fluids with substantial non-volatile constituent parts
US6200289B1 (en) 1998-04-10 2001-03-13 Milestone Scientific, Inc. Pressure/force computer controlled drug delivery system and the like
US6211856B1 (en) 1998-04-17 2001-04-03 Sung M. Choi Graphical user interface touch screen with an auto zoom feature
US7647237B2 (en) 1998-04-29 2010-01-12 Minimed, Inc. Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like
TW406018B (en) 1998-05-21 2000-09-21 Elan Corp Plc Improved adhesive system for medical devices
CO5070568A1 (es) 1998-05-22 2001-08-28 Eurand Internatrional Spa Proceso de aplicacion de capas y aparato para efectuarlo
EP1082159B1 (en) 1998-05-29 2009-04-01 Lawrence A. Lynn Luer receiver and method for fluid transfer
DE19824016C1 (de) * 1998-05-29 2000-02-03 Fresenius Ag Implantierbare Vorrichtung zur Applikation einer Wirklösung
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US6364859B1 (en) 1998-06-16 2002-04-02 Robbins Scientific Corporation Locking cap for replaceable needle assembly
US6537268B1 (en) * 1998-06-18 2003-03-25 Medtronic Minimed, Inc. Medical infusion device with a source of controlled compliance
US6007941A (en) 1998-06-19 1999-12-28 Abbott Laboratories Watertight battery compartment cover with latch actuated o-ring seal
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US5951521A (en) 1998-09-25 1999-09-14 Minimed Inc. Subcutaneous implantable sensor set having the capability to remove deliver fluids to an insertion site
US6254586B1 (en) 1998-09-25 2001-07-03 Minimed Inc. Method and kit for supplying a fluid to a subcutaneous placement site
US6402689B1 (en) * 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
CA2653180C (en) 1998-09-30 2013-11-19 Medtronic Minimed, Inc. Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like
AU6255699A (en) 1998-10-08 2000-04-26 Minimed, Inc. Telemetered characteristic monitor system
US6817990B2 (en) 1998-10-29 2004-11-16 Medtronic Minimed, Inc. Fluid reservoir piston
AU1456700A (en) 1998-10-29 2000-05-22 Minimed, Inc. Compact pump drive system
US6800071B1 (en) 1998-10-29 2004-10-05 Medtronic Minimed, Inc. Fluid reservoir piston
US7621893B2 (en) 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US20020173748A1 (en) 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
AU6513499A (en) 1998-10-30 2000-05-22 Immunex Corporation Method and apparatus for operating a syringe and vial for injections
US6156013A (en) * 1998-11-04 2000-12-05 Mahurkar; Sakharam D. Safety syringe
US6164921A (en) 1998-11-09 2000-12-26 Moubayed; Ahmad Maher Curvilinear peristaltic pump having insertable tubing assembly
CA2350706A1 (en) 1998-11-13 2000-05-25 Elan Pharma International Limited Drug delivery systems and methods
US6964643B2 (en) 1998-11-18 2005-11-15 Nugyn, Inc. Devices and methods for treatment of incontinence
AU765742B2 (en) 1998-11-30 2003-09-25 Novo Nordisk A/S A method and a system for assisting a user in a medical self treatment, said self treatment comprising a plurality of actions
US6406455B1 (en) 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
US5997546A (en) 1999-01-07 1999-12-07 Ballard Medical Products Gastric balloon catheter with improved balloon orientation
US6364866B1 (en) * 1999-01-22 2002-04-02 Douglas Furr Syringe loading aid
FR2789369B1 (fr) 1999-02-10 2001-04-27 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
US20040158193A1 (en) 1999-02-10 2004-08-12 Baxter International Inc. Medical apparatus using selective graphical interface
US6375638B2 (en) 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6314317B1 (en) 1999-02-18 2001-11-06 Biovalve Technologies, Inc. Electroactive pore
US6283943B1 (en) 1999-02-19 2001-09-04 Minimed Inc. Negative pressure pump
US6866881B2 (en) 1999-02-19 2005-03-15 Speedline Technologies, Inc. Dispensing system and method
US6280416B1 (en) 1999-02-19 2001-08-28 Minimed Inc. Constant flow medication infusion pump
WO2000058016A1 (en) 1999-03-31 2000-10-05 Shofner Engineering Associates, Inc. Controlled deliveries and depositions of pharmaceutical and other aerosolized masses
US20040069044A1 (en) 1999-04-29 2004-04-15 Gilad Lavi Device for measuring a volume of drug
GB9910985D0 (en) 1999-05-12 1999-07-14 Smiths Industries Plc Syringe pumps
US6461331B1 (en) 1999-05-21 2002-10-08 Minimed Inc. Device and method for infusion of small molecule insulin mimetic materials
US6321597B1 (en) 1999-05-28 2001-11-27 Deka Products Limited Partnership System and method for measuring volume of liquid in a chamber
US6458102B1 (en) 1999-05-28 2002-10-01 Medtronic Minimed, Inc. External gas powered programmable infusion device
US7068361B2 (en) 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US6752787B1 (en) 1999-06-08 2004-06-22 Medtronic Minimed, Inc., Cost-sensitive application infusion device
US6719728B2 (en) * 1999-06-16 2004-04-13 Breg, Inc. Patient-controlled medication delivery system with overmedication prevention
US6270481B1 (en) * 1999-06-16 2001-08-07 Breg, Inc. Patient-controlled medication delivery system
US6259587B1 (en) 1999-06-17 2001-07-10 Minimed Inc. Direct current motor safety circuits for fluid delivery systems
US6423035B1 (en) 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
WO2001000261A1 (en) 1999-06-30 2001-01-04 Baxter International Inc. Syringe for transfer of medication from a prefilled medication container
GB9915525D0 (en) 1999-07-03 1999-09-01 Smiths Industries Plc Syringe pumps
US6804558B2 (en) 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US20020052539A1 (en) 1999-07-07 2002-05-02 Markus Haller System and method for emergency communication between an implantable medical device and a remote computer system or health care provider
US7149773B2 (en) * 1999-07-07 2006-12-12 Medtronic, Inc. System and method of automated invoicing for communications between an implantable medical device and a remote computer system or health care provider
US7181505B2 (en) 1999-07-07 2007-02-20 Medtronic, Inc. System and method for remote programming of an implantable medical device
US6302653B1 (en) * 1999-07-20 2001-10-16 Deka Products Limited Partnership Methods and systems for detecting the presence of a gas in a pump and preventing a gas from being pumped from a pump
US6416293B1 (en) * 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
US6877713B1 (en) * 1999-07-20 2005-04-12 Deka Products Limited Partnership Tube occluder and method for occluding collapsible tubes
US6382923B1 (en) * 1999-07-20 2002-05-07 Deka Products Ltd. Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
US6428509B1 (en) 1999-07-29 2002-08-06 Alaris Medical Systems, Inc. Syringe plunger driver system and method
WO2001008727A1 (en) 1999-07-30 2001-02-08 Medrad, Inc. Injector systems and syringe adapters for use therewith
US6224346B1 (en) * 1999-08-09 2001-05-01 Medimop Medical Projects, Ltd. Fluid pump
US6459424B1 (en) 1999-08-10 2002-10-01 Hewlett-Packard Company Touch-sensitive input screen having regional sensitivity and resolution properties
EP1203156B1 (en) * 1999-08-12 2006-11-02 Perihelian, LLC Shape-memory alloy actuators and control methods
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US7933780B2 (en) 1999-10-22 2011-04-26 Telaric, Llc Method and apparatus for controlling an infusion pump or the like
US7063684B2 (en) 1999-10-28 2006-06-20 Medtronic Minimed, Inc. Drive system seal
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6253804B1 (en) 1999-11-05 2001-07-03 Minimed Inc. Needle safe transfer guard
US6453956B2 (en) 1999-11-05 2002-09-24 Medtronic Minimed, Inc. Needle safe transfer guard
US6208107B1 (en) * 1999-12-03 2001-03-27 Abbott Laboratories Use of digital current ramping to reduce audible noise in stepper motor
US6497680B1 (en) * 1999-12-17 2002-12-24 Abbott Laboratories Method for compensating for pressure differences across valves in cassette type IV pump
WO2001045793A1 (en) 1999-12-21 2001-06-28 Medtronic, Inc. System for dynamic remote networking with implantable medical devices
US8002700B2 (en) * 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
WO2001051109A1 (en) 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
US6764472B1 (en) * 2000-01-11 2004-07-20 Bard Access Systems, Inc. Implantable refillable infusion device
US20020120231A1 (en) * 2000-01-18 2002-08-29 Douglas Joel S. Subcutaneous injection set with secondary injection septum
US6733446B2 (en) 2000-01-21 2004-05-11 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods
JP4777574B2 (ja) 2000-02-11 2011-09-21 レスピロニクス・レスピラトリー・ドラッグ・デリバリー・(ユーケー)・リミテッド 薬剤投与装置
UA73967C2 (en) 2000-02-14 2005-10-17 First Opinion Corp Structure-based automatic processing for diagnostics (variants)
US20030060765A1 (en) 2000-02-16 2003-03-27 Arthur Campbell Infusion device menu structure and method of using the same
US6948697B2 (en) * 2000-02-29 2005-09-27 Arichell Technologies, Inc. Apparatus and method for controlling fluid flow
US20010027384A1 (en) 2000-03-01 2001-10-04 Schulze Arthur E. Wireless internet bio-telemetry monitoring system and method
US6485471B1 (en) * 2000-03-03 2002-11-26 Roche Diagnostics Corporation Bellowed fluid delivery apparatus
US6572542B1 (en) 2000-03-03 2003-06-03 Medtronic, Inc. System and method for monitoring and controlling the glycemic state of a patient
US6461329B1 (en) 2000-03-13 2002-10-08 Medtronic Minimed, Inc. Infusion site leak detection system and method of using the same
WO2001070304A1 (en) 2000-03-22 2001-09-27 Docusys, Inc. A drug delivery and monitoring system
US20010041869A1 (en) 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
TW523415B (en) 2000-03-24 2003-03-11 Novo Nordisk As A flexible piston rod
US6485465B2 (en) * 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6485461B1 (en) 2000-04-04 2002-11-26 Insulet, Inc. Disposable infusion device
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US6692472B2 (en) * 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6699230B2 (en) 2000-05-10 2004-03-02 Minnesota Medical Physics, Llc Apparatus and method for out-of-hospital thrombolytic therapy
US6478783B1 (en) * 2000-05-26 2002-11-12 H. Robert Moorehead Anti-sludge medication ports and related methods
TW499314B (en) 2000-05-30 2002-08-21 Novo Nordisk As A medication delivery device with replaceable cooperating modules and a method of making same
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6542080B2 (en) * 2000-06-10 2003-04-01 Phillip R. Page Monitoring device to prevent separation
US20020056114A1 (en) 2000-06-16 2002-05-09 Fillebrown Lisa A. Transmitter for a personal wireless network
US6577901B2 (en) 2000-06-23 2003-06-10 Medtronic, Inc. Network compatible RF wireless link for medical device data management
US6620140B1 (en) 2000-06-30 2003-09-16 Ethicon, Inc. Method and an apparatus for a port access system
AU2001279282A1 (en) 2000-07-07 2002-01-21 Fluidsense Corporation Pump cassette with controlled pump force
US6503062B1 (en) * 2000-07-10 2003-01-07 Deka Products Limited Partnership Method for regulating fluid pump pressure
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
AU2001278417A1 (en) 2000-07-14 2002-01-30 Novo-Nordisk A/S A liquid medication delivery device and a method of delivering an intended dose
US9772311B2 (en) * 2000-07-14 2017-09-26 Acosense Ab Active acoustic method for predicting properties of process fluids comprising solid particles or gas/liquid volumes based on their size distribution and concentration
CA2717387C (en) 2000-07-20 2013-05-21 Acist Medical Systems, Inc. Syringe plunger locking mechanism
DE10036830A1 (de) 2000-07-28 2002-02-21 Schott Glas Dosierbehälter
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6642936B1 (en) 2000-08-08 2003-11-04 Tektronix, Inc. Touch zoom in/out for a graphics display
US6554800B1 (en) 2000-08-09 2003-04-29 Medtronic Minimed, Inc. Compact pump motor system and dispensing process
ATE354389T1 (de) 2000-08-10 2007-03-15 Novo Nordisk As Vorrichtung zur verabreichung von medikamenten mit einem halter für eine kassette
JP2004505730A (ja) * 2000-08-15 2004-02-26 ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション プログラム可能多用量鼻腔内薬物送達デバイス
US6475196B1 (en) 2000-08-18 2002-11-05 Minimed Inc. Subcutaneous infusion cannula
WO2002015778A1 (en) * 2000-08-18 2002-02-28 Cygnus, Inc. Analyte monitoring device alarm augmentation system
WO2002015965A2 (en) 2000-08-18 2002-02-28 Becton Dickinson And Company Constant rate fluid delivery device with selectable flow rate and titratable bolus button
US6497697B1 (en) * 2000-09-02 2002-12-24 Michael Cohn Syringe guide and vial holder
EP1335764B1 (en) 2000-09-08 2007-06-06 Insulet Corporation Device and system for patient infusion
US6669669B2 (en) 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
US20040260233A1 (en) 2000-09-08 2004-12-23 Garibotto John T. Data collection assembly for patient infusion system
US6704034B1 (en) 2000-09-28 2004-03-09 International Business Machines Corporation Method and apparatus for providing accessibility through a context sensitive magnifying glass
AU2001296588B2 (en) 2000-10-04 2006-06-08 Insulet Corporation Data collection assembly for patient infusion system
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
WO2002030264A2 (en) * 2000-10-10 2002-04-18 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US6416495B1 (en) * 2000-10-10 2002-07-09 Science Incorporated Implantable fluid delivery device for basal and bolus delivery of medicinal fluids
US6738671B2 (en) 2000-10-26 2004-05-18 Medtronic, Inc. Externally worn transceiver for use with an implantable medical device
US6508788B2 (en) 2000-10-27 2003-01-21 Novo Nordisk A/S Medication delivery device with telescopic piston rod
US6613044B2 (en) 2000-10-30 2003-09-02 Allen Carl Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy
DE60132909T2 (de) * 2000-11-03 2009-02-12 Allergan Medical S.A. Implantierbare medizinische vorrichtung zum abgeben einer flüssigkeit
EP1695727B1 (en) 2000-11-09 2008-07-23 Insulet Corporation Transcutaneous delivery means
JP4523143B2 (ja) 2000-11-10 2010-08-11 シチズンホールディングス株式会社 濃度測定装置及び糖度測定装置
CA2430590C (en) 2000-11-30 2012-08-14 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
US7150409B2 (en) 2000-11-30 2006-12-19 Biovalve Technologies, Inc. Injection systems
US20020072720A1 (en) * 2000-12-11 2002-06-13 Hague Clifford W. Rigid soluble materials for use with needle-less infusion sets, sensor sets and injection devices and methods of making the same
JP4478323B2 (ja) 2000-12-18 2010-06-09 株式会社やまびこ 4サイクル内燃エンジン
US7052483B2 (en) * 2000-12-19 2006-05-30 Animas Corporation Transcutaneous inserter for low-profile infusion sets
AU2002231207A1 (en) 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
EP1347705B1 (en) 2000-12-21 2005-12-07 Insulet Corporation Medical apparatus remote control
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
US6983381B2 (en) * 2001-01-17 2006-01-03 Arcot Systems, Inc. Methods for pre-authentication of users using one-time passwords
WO2002056945A2 (en) 2001-01-18 2002-07-25 Medrad, Inc. Syringe interfaces and syringe adapters for use with medical injectors
US7025757B2 (en) 2001-02-08 2006-04-11 Medrad, Inc. Syringe loading devices for use with syringes and medical injectors
EP1808193A1 (en) 2001-02-14 2007-07-18 Novo Nordisk A/S Electronically controlled device
US6819247B2 (en) 2001-02-16 2004-11-16 Locast Corporation Apparatus, method, and system for remote monitoring of need for assistance based on change in velocity
CN1556716A (zh) 2001-02-22 2004-12-22 ���Ͽع����޹�˾ 模块化的输注装置和方法
DE60235964D1 (de) 2001-02-22 2010-05-27 Terumo Corp Spritzenpumpe
US20040034331A1 (en) * 2001-02-23 2004-02-19 Jason Toman Integrated medication delivery system
EP1379291A4 (en) * 2001-02-23 2008-09-24 Stryker Instr INTEGRATED DRUG DELIVERY SYSTEM
JP4387105B2 (ja) * 2001-03-04 2009-12-16 アイシーユー・メディカル・インコーポレーテッド インフュージョンハブアセンブリおよび流体ライン切断システム
WO2002074406A1 (en) 2001-03-14 2002-09-26 Penjet Corporation System and method for removing dissolved gas from a solution
AU2002244317A1 (en) * 2001-03-21 2002-10-08 Innovent, Llc. Inverted peristaltic pump
US6770302B2 (en) * 2001-03-30 2004-08-03 Department Of Biotechnology Indian green mussel (Perna viridis) as a source of anti-HIV activity
US6879930B2 (en) * 2001-03-30 2005-04-12 Microsoft Corporation Capacitance touch slider
DK3210637T3 (da) 2001-04-06 2021-04-06 Hoffmann La Roche Infusionssæt
WO2002083209A1 (en) 2001-04-13 2002-10-24 Nipro Diabetes Systems Drive system for an infusion pump
US6773412B2 (en) * 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
US6743204B2 (en) * 2001-04-13 2004-06-01 Medtronic, Inc. Implantable drug delivery device with peristaltic pump having retracting roller
US20020071225A1 (en) 2001-04-19 2002-06-13 Minimed Inc. Direct current motor safety circuits for fluid delivery systems
CA2445044C (en) 2001-04-25 2011-02-15 Amnis Corporation Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
US6494694B2 (en) 2001-04-25 2002-12-17 Abbott Laboratories Disposable infusion cassette with low air bubble retention and improved valves
US7088343B2 (en) 2001-04-30 2006-08-08 Lenovo (Singapore) Pte., Ltd. Edge touchpad input device
WO2002087696A1 (en) * 2001-04-30 2002-11-07 Medtronic,Inc. Transcutaneous monitor and method of use, using therapeutic output from an implanted medical device
DE10131152B4 (de) 2001-04-30 2004-05-27 Nutricia Healthcare S.A. Medizinisches Ballon-Button-System
CA2446488A1 (en) 2001-05-07 2002-11-14 Cardiosafe International Ag Device for monitoring a patient
EP2140891B1 (en) 2001-05-18 2013-03-27 DEKA Products Limited Partnership Conduit for coupling to a fluid delivery device
US7216536B2 (en) * 2001-06-22 2007-05-15 Young Manufacturing & Engineering, Inc. Acoustic volume indicator
US7711134B2 (en) * 2001-06-25 2010-05-04 Harman International Industries, Incorporated Speaker port system for reducing boundary layer separation
US6439276B1 (en) * 2001-07-06 2002-08-27 Trimensions, Inc. Kit for loading and disposal of hypodermic syringes used for administering medication
KR100407467B1 (ko) * 2001-07-12 2003-11-28 최수봉 리모컨 방식의 인슐린 자동주사기
US6716199B2 (en) * 2001-07-18 2004-04-06 Deharde Lawrence G. Safety syringe system
KR100421359B1 (ko) * 2001-07-24 2004-03-06 엘지전자 주식회사 탄성 재질의 기판 내에서 유체를 이송하는 방법 및 이를위한 장치
US20080177154A1 (en) * 2001-08-13 2008-07-24 Novo Nordisk A/S Portable Device and Method Of Communicating Medical Data Information
US6802823B2 (en) * 2001-08-22 2004-10-12 Breg, Inc. Medication delivery system having selective automated or manual discharge
RU2318492C2 (ru) 2001-08-27 2008-03-10 Ново Нордиск А/С Баллончик и система подачи лекарственного препарата, включающая в себя такой баллончик
US6691043B2 (en) 2001-08-28 2004-02-10 Maxi-Med, Llc Bolus calculator
US6779665B2 (en) * 2001-08-29 2004-08-24 Henry Bolanos Genealogy storage kit
EP1291659A3 (en) 2001-09-06 2008-05-21 Sysmex Corporation Automatic sample analyzer and its components
US6770067B2 (en) 2001-09-07 2004-08-03 Medtronic Minimed, Inc. Infusion device and driving mechanism for same
US7186236B2 (en) * 2001-09-07 2007-03-06 Medtronic Minimed, Inc. Infusion device and inlet structure for same
US6740072B2 (en) 2001-09-07 2004-05-25 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US6652510B2 (en) 2001-09-07 2003-11-25 Medtronic Minimed, Inc. Implantable infusion device and reservoir for same
US6595756B2 (en) 2001-09-07 2003-07-22 Medtronic Minimed, Inc. Electronic control system and process for electromagnetic pump
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US6997921B2 (en) 2001-09-07 2006-02-14 Medtronic Minimed, Inc. Infusion device and driving mechanism for same
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US6845465B2 (en) * 2001-09-17 2005-01-18 Sun Microsystems, Inc. Method and system for leveraging spares in a data storage system including a plurality of disk drives
US20030055380A1 (en) 2001-09-19 2003-03-20 Flaherty J. Christopher Plunger for patient infusion device
US20060122577A1 (en) 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
US20030088238A1 (en) 2001-09-26 2003-05-08 Poulsen Jens Ulrik Modular drug delivery system
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US6506179B1 (en) 2001-10-12 2003-01-14 Abbott Laboratories Tube having a retention member
EP1438252A1 (en) * 2001-10-19 2004-07-21 MonoGen, Inc. Container uncapping apparatus and method
US7011608B2 (en) 2001-10-19 2006-03-14 Spencer Bruce L Pneumatic pogo stick
US7046230B2 (en) 2001-10-22 2006-05-16 Apple Computer, Inc. Touch pad handheld device
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040078028A1 (en) * 2001-11-09 2004-04-22 Flaherty J. Christopher Plunger assembly for patient infusion device
US6549423B1 (en) 2001-11-15 2003-04-15 Ge Medical Systems Information Technologies, Inc. Medical device having a side loading battery compartment
US20030105430A1 (en) * 2001-11-30 2003-06-05 Elan Pharma International Limited Wil House Automatic injector
US20040030365A1 (en) * 2001-11-30 2004-02-12 Leo Rubin Medical device to restore functions of a fibrillating heart by cardiac therapies remotely directed by a physician via two-way communication
US6752299B2 (en) 2001-12-07 2004-06-22 Medtronic Minimed, Inc. Rotational holster for an electronic device
US6665909B2 (en) 2001-12-14 2003-12-23 Medtronic Minimed, Inc. Low-profile mounting clip for personal device
US6715516B2 (en) 2001-12-19 2004-04-06 Novo Nordisk A/S Method and apparatus for filling cartridges with a liquid
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
RU2240142C2 (ru) 2001-12-26 2004-11-20 Закрытое акционерное общество "МедСил" Устройство для дозированной подачи жидкости
AU2002351753A1 (en) 2001-12-29 2003-07-30 Novo Nordisk A/S Combined use of a glp-1 compound and a modulator of diabetic late complications
US20030198666A1 (en) * 2002-01-07 2003-10-23 Richat Abbas Oral insulin therapy
US20030132922A1 (en) 2002-01-17 2003-07-17 Harald Philipp Touch screen detection apparatus
GB2384198B (en) 2002-01-18 2005-03-02 Profile Drug Delivery Ltd Nebulizer metering
US7107837B2 (en) 2002-01-22 2006-09-19 Baxter International Inc. Capacitance fluid volume measurement
US6897773B2 (en) * 2002-01-25 2005-05-24 Alfred Dennis Ridley Computer powered wire(less) ultra-intelligent real-time monitor
US8489427B2 (en) 2002-01-29 2013-07-16 Baxter International Inc. Wireless medical data communication system and method
US20030140929A1 (en) 2002-01-29 2003-07-31 Wilkes Gordon J. Infusion therapy bar coding system and method
US20030141981A1 (en) 2002-01-29 2003-07-31 Tuan Bui System and method for operating medical devices
US10173008B2 (en) * 2002-01-29 2019-01-08 Baxter International Inc. System and method for communicating with a dialysis machine through a network
MXPA04007389A (es) 2002-02-04 2004-10-11 Becton Dickinson Co Dispositivo y metodo para entregar o retirar una substancia a traves de la piel.
US7171008B2 (en) * 2002-02-05 2007-01-30 Mh Acoustics, Llc Reducing noise in audio systems
US7075512B1 (en) 2002-02-07 2006-07-11 Palmsource, Inc. Method and system for navigating a display screen for locating a desired item of information
US6932114B2 (en) * 2002-02-22 2005-08-23 Integrated Sensing Systems, Inc. Fluid delivery system and method
US20030212379A1 (en) 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
US20030163089A1 (en) 2002-02-28 2003-08-28 Bynum Gail Beth Child safety cap for syringe pump
US7041082B2 (en) 2002-02-28 2006-05-09 Smiths Medical Md, Inc. Syringe pump control systems and methods
US7033338B2 (en) 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
US6852104B2 (en) 2002-02-28 2005-02-08 Smiths Medical Md, Inc. Programmable insulin pump
US6744350B2 (en) 2002-02-28 2004-06-01 Smiths Medical Md, Inc. Insulin pump having missed meal bolus alarm
US6692457B2 (en) 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6830558B2 (en) 2002-03-01 2004-12-14 Insulet Corporation Flow condition sensor assembly for patient infusion device
US8043213B2 (en) * 2002-12-18 2011-10-25 Cardiac Pacemakers, Inc. Advanced patient management for triaging health-related data using color codes
US6805687B2 (en) * 2002-03-22 2004-10-19 Codman & Shurtleff, Inc. Infusion pump with access regulator
US6936006B2 (en) 2002-03-22 2005-08-30 Novo Nordisk, A/S Atraumatic insertion of a subcutaneous device
US6976976B2 (en) * 2002-03-27 2005-12-20 Safety Syringes, Inc. Syringe with needle guard injection device
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6644365B1 (en) * 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
US7052251B2 (en) * 2002-04-22 2006-05-30 Medtronic Minimed, Inc. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US20050238507A1 (en) 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US20040153032A1 (en) * 2002-04-23 2004-08-05 Garribotto John T. Dispenser for patient infusion device
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US20040176667A1 (en) 2002-04-30 2004-09-09 Mihai Dan M. Method and system for medical device connectivity
US8234128B2 (en) 2002-04-30 2012-07-31 Baxter International, Inc. System and method for verifying medical device operational parameters
US20050055242A1 (en) 2002-04-30 2005-03-10 Bryan Bello System and method for medical data tracking, analysis and reporting for healthcare system
US20040167465A1 (en) 2002-04-30 2004-08-26 Mihai Dan M. System and method for medical device authentication
US20040172301A1 (en) 2002-04-30 2004-09-02 Mihai Dan M. Remote multi-purpose user interface for a healthcare system
US20050065817A1 (en) 2002-04-30 2005-03-24 Mihai Dan M. Separation of validated information and functions in a healthcare system
US6902207B2 (en) 2002-05-01 2005-06-07 Medtronic Minimed, Inc. Self sealing disconnect device
US7083595B2 (en) 2002-05-01 2006-08-01 Scimed Lipe Systems, Inc. Medical catheter assembly and method of using the same
AU2003243305A1 (en) * 2002-05-22 2003-12-12 Medical Research Products-A, Inc. Implantable medication delivery device
US6979316B1 (en) * 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US7153286B2 (en) 2002-05-24 2006-12-26 Baxter International Inc. Automated dialysis system
US6978181B1 (en) * 2002-05-24 2005-12-20 Pacesetter, Inc. Inter-programmer communication among programmers of implantable medical devices
US6929751B2 (en) 2002-05-24 2005-08-16 Baxter International Inc. Vented medical fluid tip protector methods
US7150724B2 (en) 2002-06-05 2006-12-19 Cardinal Health 303, Inc. Syringe plunger driver system
US6723072B2 (en) 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
US20080132842A1 (en) 2002-06-06 2008-06-05 Flaherty J Christopher Plunger assembly for patient infusion device
US6997905B2 (en) 2002-06-14 2006-02-14 Baxter International Inc. Dual orientation display for a medical device
US7018361B2 (en) 2002-06-14 2006-03-28 Baxter International Inc. Infusion pump
US7338465B2 (en) * 2002-07-02 2008-03-04 Patton Medical Devices, Lp Infusion device and method thereof
AU2003239785A1 (en) * 2002-07-10 2004-02-02 Novo Nordisk A/S An injection device with a dose setting limiter
US20040010207A1 (en) 2002-07-15 2004-01-15 Flaherty J. Christopher Self-contained, automatic transcutaneous physiologic sensing system
US7018360B2 (en) 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US7238164B2 (en) * 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
USD480477S1 (en) 2002-07-19 2003-10-07 Becton Dickinson And Co. Stopper for a syringe plunger rod
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
US8512276B2 (en) 2002-07-24 2013-08-20 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US20040068230A1 (en) 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
JP2005533545A (ja) 2002-07-24 2005-11-10 エム2・メディカル・アクティーゼルスカブ 注入ポンプシステム、注入ポンプユニット、注入ポンプ
MXPA05001079A (es) 2002-07-26 2005-06-03 Oakley Inc Audifonos interactivos inalambricos.
US20040059316A1 (en) 2002-07-31 2004-03-25 Smedegaard Jorgen K. Medical delivery device
US7108659B2 (en) * 2002-08-01 2006-09-19 Healthetech, Inc. Respiratory analyzer for exercise use
US6767188B2 (en) 2002-08-15 2004-07-27 Becton, Dickinson And Company Constant output fluidic system
US7551749B2 (en) * 2002-08-23 2009-06-23 Bose Corporation Baffle vibration reducing
US6733464B2 (en) * 2002-08-23 2004-05-11 Hewlett-Packard Development Company, L.P. Multi-function sensor device and methods for its use
DE60309487T2 (de) * 2002-09-09 2007-09-20 Novo Nordisk A/S Flussbeschränker mit sicherheitsmerkmal
US20040116905A1 (en) 2002-09-09 2004-06-17 Pedersen Per Elgard Flow restrictor with safety feature
US7404796B2 (en) 2004-03-01 2008-07-29 Becton Dickinson And Company System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor
US7637891B2 (en) * 2002-09-12 2009-12-29 Children's Hospital Medical Center Method and device for painless injection of medication
US6962580B2 (en) * 2002-09-17 2005-11-08 Transoma Medical, Inc. Vascular access port with needle detector
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
EP1403519A1 (en) 2002-09-27 2004-03-31 Novo Nordisk A/S Membrane pump with stretchable pump membrane
EP1551480B1 (en) 2002-09-30 2009-05-13 Novo Nordisk A/S Indicating device with estimating feature
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
WO2004030726A1 (en) 2002-10-07 2004-04-15 Novo Nordisk A/S Needle device comprising a plurality of needles
EP1552146B1 (en) 2002-10-09 2011-04-20 Abbott Diabetes Care Inc. Fluid delivery device, system and method
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
EP1549367B1 (en) 2002-10-11 2016-04-06 Becton Dickinson and Company Flush syringe having compressible plunger
AU2003286451A1 (en) * 2002-10-15 2004-05-04 Medtronic Inc. Signal quality monitoring and control for a medical device system
WO2004035116A1 (en) 2002-10-16 2004-04-29 Abbott Laboratories Medical cassette pump with single force sensor to determine the operating status
WO2004041330A2 (en) * 2002-11-05 2004-05-21 M 2 Medical A/S A disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US6939319B1 (en) * 2002-11-20 2005-09-06 Conrad Anstead Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
US20040133166A1 (en) 2002-11-22 2004-07-08 Minimed Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US20040106899A1 (en) 2002-11-30 2004-06-03 Mcmichael Donald J. Gastric balloon catheter with improved balloon orientation
US20040116866A1 (en) 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
GB2396816A (en) * 2002-12-17 2004-07-07 Pa Consulting Services Injection device
CN1738656A (zh) 2002-12-23 2006-02-22 M2医药有限公司 一种一次性使用的可佩戴的胰岛素分配装置,这种装置和程序控制器的组合,以及控制这种装置工作的方法
US7270648B2 (en) 2002-12-23 2007-09-18 Farhad Kazemzadeh Drug delivery apparatus
US7127300B2 (en) * 2002-12-23 2006-10-24 Cardiac Pacemakers, Inc. Method and apparatus for enabling data communication between an implantable medical device and a patient management system
US6932584B2 (en) 2002-12-26 2005-08-23 Medtronic Minimed, Inc. Infusion device and driving mechanism and process for same with actuator for multiple infusion uses
US6978182B2 (en) 2002-12-27 2005-12-20 Cardiac Pacemakers, Inc. Advanced patient management system including interrogator/transceiver unit
US7289029B2 (en) * 2002-12-31 2007-10-30 Medtronic Physio-Control Corp. Communication between emergency medical device and safety agency
US20040140304A1 (en) 2003-01-22 2004-07-22 Leyendecker Kurt Philip Baby bottle chiller/warmer and method of use
US6966639B2 (en) * 2003-01-28 2005-11-22 Hewlett-Packard Development Company, L.P. Ink cartridge and air management system for an ink cartridge
TWI236611B (en) 2003-02-01 2005-07-21 Baxter Int Medical data communication notification and messaging system and method
IL154243A0 (en) * 2003-02-02 2003-09-17 Silex Projectors Ltd Stable infusion device
US7229419B2 (en) * 2003-02-11 2007-06-12 Promex/U.S. Biosy Llc Single-handed biopsy system
US7329241B2 (en) 2003-02-14 2008-02-12 Valeant Pharmaceuticals North America Drug delivery system for administering an adjustable preset dose
US7806166B1 (en) 2003-02-18 2010-10-05 Parker-Hannifin Corporation Insulated spray cooling system for extreme environments
US6994619B2 (en) 2003-03-04 2006-02-07 Triatek, Inc. Optical sash sensing system for fume hoods
US7390314B2 (en) 2003-03-05 2008-06-24 Medtronic Minimed, Inc. Lead screw driven reservoir with integral plunger nut and method of using the same
ITTO20030196A1 (it) * 2003-03-14 2004-09-15 Fiat Ricerche Attuatore rotativo a passi discreti.
NZ542646A (en) * 2003-03-28 2008-10-31 Cardinal Health 303 Inc Infusion data communication system
US20040199212A1 (en) * 2003-04-01 2004-10-07 Fischell David R. External patient alerting system for implantable devices
US7061140B2 (en) 2003-04-16 2006-06-13 General Instrument Corportion Power supply, and apparatus and method for operating a power supply
WO2004093648A2 (en) 2003-04-18 2004-11-04 Insulet Corporation User interface for infusion pump remote controller and method of using the same
US20050182366A1 (en) 2003-04-18 2005-08-18 Insulet Corporation Method For Visual Output Verification
US6930602B2 (en) 2003-04-25 2005-08-16 Medtronic, Inc. Coaxial cable antenna for communication with implanted medical devices
US20060097013A1 (en) * 2003-04-28 2006-05-11 Bargh Adrian N Dispenser
US20040220551A1 (en) 2003-04-30 2004-11-04 Flaherty J. Christopher Low profile components for patient infusion device
WO2004098390A2 (en) 2003-04-30 2004-11-18 Insulet Corporation Rf medical device
ATE474611T1 (de) 2003-05-08 2010-08-15 Novo Nordisk As Eine auf die haut aufbringbare injektionsvorrichtung mit abtrennbarem betätigungsteil zum einführen der nadel
ATE392223T1 (de) 2003-05-08 2008-05-15 Novo Nordisk As Interne nadeleinführvorrichtung
US6926694B2 (en) * 2003-05-09 2005-08-09 Medsolve Technologies, Llc Apparatus and method for delivery of therapeutic and/or diagnostic agents
WO2005000382A2 (en) 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
US20050020980A1 (en) 2003-06-09 2005-01-27 Yoshio Inoue Coupling system for an infusion pump
US7819847B2 (en) * 2003-06-10 2010-10-26 Hewlett-Packard Development Company, L.P. System and methods for administering bioactive compositions
US7112205B2 (en) * 2003-06-17 2006-09-26 Boston Scientific Scimed, Inc. Apparatus and methods for delivering compounds into vertebrae for vertebroplasty
US7494459B2 (en) * 2003-06-26 2009-02-24 Biophan Technologies, Inc. Sensor-equipped and algorithm-controlled direct mechanical ventricular assist device
US20060167334A1 (en) * 2003-06-26 2006-07-27 Anstadt Mark P Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress
ATE357939T1 (de) 2003-07-08 2007-04-15 Novo Nordisk As Tragbares medikamentenabgabegerät mit einer eingekapselten nadel
US7722536B2 (en) * 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US20050055244A1 (en) 2003-07-18 2005-03-10 Janet Mullan Wireless medical communication system and method
GB0317801D0 (en) * 2003-07-30 2003-09-03 Intersurgical Ltd Improvements relating to exhalation valves
EP1502613A1 (en) * 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
DE20311996U1 (de) * 2003-08-01 2003-10-16 Hoelzle Dieter Tech Projekte Injektionsvorrichtung
US8444604B2 (en) 2003-08-12 2013-05-21 Becton, Dickinson And Company Patch-like infusion device
US6979306B2 (en) 2003-08-13 2005-12-27 Moll Family Trust Method and device for monitoring loss of body fluid and dislodgment of medical instrument from body
US7311879B2 (en) 2003-08-14 2007-12-25 Hodson Steve J Syringe pump
US7499040B2 (en) 2003-08-18 2009-03-03 Apple Inc. Movable touch pad with added functionality
EP1670547B1 (en) * 2003-08-18 2008-11-12 Cardiac Pacemakers, Inc. Patient monitoring system
DE212004000044U1 (de) 2003-08-21 2006-06-01 Philipp, Harald, Hamble Kapazitiver Positionssensor
US7097637B2 (en) 2003-08-27 2006-08-29 C. R. Bard, Inc. Safety needle with positive flush
US20050063857A1 (en) * 2003-09-23 2005-03-24 Alheidt Thomas A. Flush syringe having anti-reflux stopper
US7021560B2 (en) 2003-09-25 2006-04-04 Deka Products Limited Partnership System and method for aerosol delivery
US7342660B2 (en) 2003-09-25 2008-03-11 Deka Products Limited Partnership Detection system and method for aerosol delivery
US7445436B2 (en) * 2003-09-29 2008-11-04 Bausch & Lomb Incorporated Peristaltic pump with a moveable pump head
US7029456B2 (en) 2003-10-15 2006-04-18 Baxter International Inc. Medical fluid therapy flow balancing and synchronization system
US7494028B2 (en) * 2003-10-15 2009-02-24 Zavida Coffee Company Inc. Fluid dispensing system suitable for dispensing liquid flavorings
KR20060099520A (ko) 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
US8360114B2 (en) * 2003-10-23 2013-01-29 Niles Clark Apparatus and method for filing a syringe
US7314479B2 (en) * 2003-10-31 2008-01-01 Parris Wellman Space-creating retractor with vessel manipulator
US20070293781A1 (en) * 2003-11-04 2007-12-20 Nathaniel Sims Respiration Motion Detection and Health State Assesment System
US7699808B2 (en) * 2003-11-10 2010-04-20 Smiths Medical Asd, Inc. Subcutaneous infusion device and method
US7309326B2 (en) * 2003-11-18 2007-12-18 Icu Medical, Inc. Infusion set
US6946217B2 (en) 2003-12-05 2005-09-20 D & K Group, Inc. Battery lock
EP1706170A4 (en) 2003-12-12 2010-03-24 Philometron Inc MULTIPLE DEVICE FOR THE PARENTERAL DELIVERY OF MEDICAMENTS
US20050137573A1 (en) * 2003-12-19 2005-06-23 Animas Corporation System, method, and communication hub for controlling external infusion device
US7001140B2 (en) * 2003-12-30 2006-02-21 Acoustiflo, Ltd. Centrifugal fan diffuser
US20050154353A1 (en) * 2004-01-09 2005-07-14 Alheidt Thomas A. Positive displacement flush syringe
EP3323450B1 (en) * 2004-01-09 2019-10-09 Becton, Dickinson and Company Positive displacement flush syringe
CN2673404Y (zh) * 2004-01-09 2005-01-26 成都中医药大学附属医院针灸学校 多功能输液保安报警装置
WO2005072794A2 (en) * 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
US20050177111A1 (en) 2004-02-06 2005-08-11 Shaul Ozeri Miniature infusion pump
US7896841B2 (en) * 2004-02-17 2011-03-01 Children's Hospital Medical Center Injection device for administering a vaccine
US20050187515A1 (en) * 2004-02-19 2005-08-25 Advanced Neuromodulation Systems, Inc. Reduced size programmable drug pump
US20050187593A1 (en) 2004-02-23 2005-08-25 Medtronic, Inc. Implantable medical device system with communication link to home appliances
US20050185799A1 (en) * 2004-02-23 2005-08-25 Breakthrough Medical Systems Inc. Method of monitoring equipment and alert device
US8954336B2 (en) * 2004-02-23 2015-02-10 Smiths Medical Asd, Inc. Server for medical device
US8808228B2 (en) * 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US7831828B2 (en) * 2004-03-15 2010-11-09 Cardiac Pacemakers, Inc. System and method for securely authenticating a data exchange session with an implantable medical device
US7475245B1 (en) * 2004-03-15 2009-01-06 Cardiac Pacemakers, Inc. System and method for providing secure exchange of sensitive information with an implantable medical device
US8313308B2 (en) 2004-03-26 2012-11-20 Hospira, Inc. Medical infusion pump with closed loop stroke feedback system and method
CN100586495C (zh) * 2004-03-30 2010-02-03 诺和诺德公司 包括杠杆机构的致动器系统
US20050222631A1 (en) 2004-04-06 2005-10-06 Nirav Dalal Hierarchical data storage and analysis system for implantable medical devices
US7211782B2 (en) 2004-04-09 2007-05-01 Mitutoyo Corporation Precision measuring gauges with optical fiber output channels
EP1763810A2 (en) 2004-04-12 2007-03-21 Baxter International Inc. System and method for medical data tracking, analysis and reporting for a healthcare system
US7556619B2 (en) 2004-04-16 2009-07-07 Medrad, Inc. Fluid delivery system having a fluid level sensor and a fluid control device for isolating a patient from a pump device
WO2005102416A1 (en) 2004-04-27 2005-11-03 Rodney Brian Savage Medical fluid injector
ES2268612T3 (es) 2004-05-03 2007-03-16 C.R.F. Societa Consortile Per Azioni Dispositivo obturador con memoria de forma.
US6997910B2 (en) * 2004-05-03 2006-02-14 Infusive Technologies, Llc Multi-chamber, sequential dose dispensing syringe
CN100547213C (zh) * 2004-05-12 2009-10-07 朱韵成 使用记忆金属线的电子机械锁及其使用方法
US20050273080A1 (en) 2004-05-20 2005-12-08 Paul Patrick J Methods and systems for providing an interface between an ambulatory medical device and a display device
US20050261660A1 (en) * 2004-05-24 2005-11-24 Choi Soo B Method for controlling insulin pump using Bluetooth protocol
US6999854B2 (en) * 2004-05-28 2006-02-14 International Business Machines Corporation Medical infusion pump capable of learning bolus time patterns and providing bolus alerts
US20050267550A1 (en) 2004-05-28 2005-12-01 Medtronic Minimed, Inc. System and method for medical communication device and communication protocol for same
US8251981B2 (en) 2004-06-07 2012-08-28 Medtronic, Inc. Regulator
US7766885B2 (en) 2004-06-07 2010-08-03 Medtronic, Inc. Drug delivery system
GB0412787D0 (en) 2004-06-09 2004-07-14 Koninkl Philips Electronics Nv Input system
GB0414054D0 (en) * 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US20050285880A1 (en) 2004-06-23 2005-12-29 Inventec Appliances Corporation Method of magnifying a portion of display
US8343074B2 (en) * 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US7246551B2 (en) * 2004-07-09 2007-07-24 Protedyne Corporation Liquid handling device with surface features at a seal
US20080027513A1 (en) * 2004-07-09 2008-01-31 Advanced Bionics Corporation Systems And Methods For Using A Butterfly Coil To Communicate With Or Transfer Power To An Implantable Medical Device
US20070197878A1 (en) * 2004-07-09 2007-08-23 Dror Shklarski Wearable device, system and method for monitoring physiological and/or environmental parameters
US8017890B2 (en) 2004-07-20 2011-09-13 Massachusetts Institute Of Technology Continuous capacitive slider controller for a smooth surfaced cooktop
JP4379240B2 (ja) 2004-07-20 2009-12-09 サクサ株式会社 Ip電話端末設定装置およびプログラム
US7344500B2 (en) 2004-07-27 2008-03-18 Medtronic Minimed, Inc. Sensing system with auxiliary display
US7653883B2 (en) 2004-07-30 2010-01-26 Apple Inc. Proximity detector in handheld device
US8381135B2 (en) 2004-07-30 2013-02-19 Apple Inc. Proximity detector in handheld device
US7261691B1 (en) * 2004-08-02 2007-08-28 Kwabena Asomani Personalized emergency medical monitoring and transmission system
EP1781164A1 (en) 2004-08-10 2007-05-09 Novo Nordisk A/S A method of forming a sterilised sensor package and a sterilised sensor package
US7620452B1 (en) 2004-08-10 2009-11-17 Cardiac Pacemakers, Inc. Systems and methods for managing the longevity of an implantable medical device battery
JP2008510154A (ja) 2004-08-16 2008-04-03 ノボ ノルディスク アクティーゼルスカブ バイオセンサーのための多相系生物適合型の半透過性膜
US20080294058A1 (en) * 2004-08-16 2008-11-27 Dror Shklarski Wearable Device, System and Method for Measuring a Pulse While a User is in Motion
US7737953B2 (en) 2004-08-19 2010-06-15 Synaptics Incorporated Capacitive sensing apparatus having varying depth sensing elements
CN101023343A (zh) 2004-08-20 2007-08-22 诺和诺德公司 用于生产细小传感器的制造工艺
US7522744B2 (en) 2004-08-31 2009-04-21 University Of Iowa Research Foundation System and method for adaptive bolus chasing computed tomography (CT) angiography
JP2008511374A (ja) 2004-09-03 2008-04-17 ノボ・ノルデイスク・エー/エス 血中グルコ−ス濃度を推定するためのシステム及び方法
EP1788930A1 (en) 2004-09-03 2007-05-30 Novo Nordisk A/S A method of calibrating a system for measuring the concentration of substances in body and an apparatus for exercising the method
US7758562B2 (en) * 2004-09-09 2010-07-20 Plc Medical Systems, Inc. Patient hydration system with a redundant monitoring of hydration fluid infusion
JP4999692B2 (ja) 2004-09-10 2012-08-15 ベクトン・ディキンソン・アンド・カンパニー 再形成注入装置
US20080215006A1 (en) 2004-09-22 2008-09-04 Novo Nordisk A/S Medical Device with Transcutaneous Cannula Device
CN101027675A (zh) 2004-09-23 2007-08-29 诺和诺德公司 与药物供应设备一起使用的远程指挥器
US7394458B2 (en) 2004-09-24 2008-07-01 Apple Inc. Low EMI capacitive trackpad
US7917196B2 (en) * 2005-05-09 2011-03-29 Cardiac Pacemakers, Inc. Arrhythmia discrimination using electrocardiograms sensed from multiple implanted electrodes
US20090048499A1 (en) 2004-10-18 2009-02-19 Novo Nordisk A/S Sensor film for transcutaneous insertion and a method for making the sensor film
WO2006052006A1 (en) * 2004-11-10 2006-05-18 Olympus Corporation Body-insertable apparatus
US7555348B1 (en) * 2004-11-19 2009-06-30 Pacesetter, Inc. Remote transtelephonic monitor user interface
CN101087625B (zh) * 2004-11-22 2012-02-22 因特利杰克特有限公司 用于药物供给的装置和系统
CN100579598C (zh) 2004-12-06 2010-01-13 诺和诺德公司 透气的皮肤可安装设备
ATE545361T1 (de) * 2004-12-13 2012-03-15 Koninkl Philips Electronics Nv Mobile überwachung
US7418880B1 (en) * 2004-12-13 2008-09-02 Michael P Smith Sample collector using a syringe with a side port in the barrel
US7717897B2 (en) * 2004-12-23 2010-05-18 Hospira, Inc. Medical fluid container with concave side weld
US7488311B2 (en) * 2004-12-23 2009-02-10 Hospira, Inc. Port closure system for intravenous fluid container
WO2006072416A2 (en) 2005-01-06 2006-07-13 Novo Nordisk A/S A system for analysing data and for assisting a person in navigating the data
US7601162B2 (en) * 2005-01-14 2009-10-13 Ethicon Endo-Surgery, Inc. Actuator for an implantable band
EP1841476B1 (en) 2005-01-17 2011-06-29 Novo Nordisk A/S Fluid delivery device with integrated monitoring of physiological characteristics
EP1848476A1 (en) 2005-01-24 2007-10-31 Novo Nordisk A/S Transcutaneous device assembly
PL2058020T3 (pl) * 2005-02-01 2013-03-29 Kaleo Inc Urządzenie do podawania leków
US7547281B2 (en) 2005-02-01 2009-06-16 Medtronic Minimed, Inc. Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
EP1688085A1 (en) 2005-02-02 2006-08-09 Disetronic Licensing AG Ambulatory medical device and method of communication between medical devices
US20060178633A1 (en) 2005-02-03 2006-08-10 Insulet Corporation Chassis for fluid delivery device
WO2006084464A1 (en) 2005-02-08 2006-08-17 Novo Nordisk A/S A medical apparatus with a code reader and a method for operating such apparatus
WO2006086723A2 (en) * 2005-02-11 2006-08-17 Stryker Corporation Reprogrammable fluid delivery system and method of use
US7801743B2 (en) * 2005-02-11 2010-09-21 Avaya Inc. Use of location awareness of establish communications with a target clinician in a healthcare environment
US8029468B2 (en) * 2005-02-15 2011-10-04 Bioquiddity, Inc. Fluid delivery and mixing apparatus with flow rate control
US7837653B2 (en) * 2005-02-18 2010-11-23 Bioquiddity, Inc. Fluid delivery apparatus with vial fill
ATE414551T1 (de) 2005-02-21 2008-12-15 Novo Nordisk As Verfahren zur sicherstellung von konstanter motorgeschwindigkeit bei einer injektionsvorrichtung
US20080157774A1 (en) 2005-02-23 2008-07-03 Novo Nordisk A/S Method For Testing An Electronic Circuit For Driving A Dc-Motor
WO2006089547A1 (en) 2005-02-23 2006-08-31 Novo Nordisk A/S Method and apparatus for reversing a piston rod in an injection device
JP2008531159A (ja) 2005-02-28 2008-08-14 ノボ・ノルデイスク・エー/エス 薬剤送達流量を変更する装置
DE102005009795A1 (de) 2005-03-03 2006-09-14 Wago Verwaltungsgesellschaft Mbh Mikroprozessorsystem für eine Maschinensteuerung in sicherheitszertifizierbaren Anwendungen
US8133178B2 (en) * 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
WO2006096746A1 (en) 2005-03-11 2006-09-14 Becton, Dickinson And Company Entrapped binding protein as biosensors
US7985199B2 (en) * 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US20080208627A1 (en) 2005-03-17 2008-08-28 Ole Skyggebjerg Securing Pairing of Electronic Devices
CA2597024A1 (en) 2005-03-28 2006-10-05 Insulet Corporation Fluid delivery device
US20060227117A1 (en) 2005-04-07 2006-10-12 Microsoft Corporation Circular touch sensor
WO2006108775A2 (en) 2005-04-08 2006-10-19 Novo Nordisk A/S Pump assembly with active and passive valve
US7945452B2 (en) 2005-04-11 2011-05-17 Hospira, Inc. User interface improvements for medical devices
US7645264B2 (en) * 2005-04-11 2010-01-12 Becton, Dickinson And Company Injection device with secondary reservoir
EP1877116A1 (en) 2005-04-13 2008-01-16 Novo Nordisk A/S Medical skin mountable device and system
US20060232554A1 (en) 2005-04-14 2006-10-19 Creative Technology Ltd. Scrolling interface for media player
US7355595B2 (en) 2005-04-15 2008-04-08 Microsoft Corporation Tactile device for scrolling
US7471284B2 (en) 2005-04-15 2008-12-30 Microsoft Corporation Tactile scroll bar with illuminated document position indicator
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
US8137314B2 (en) 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US7955305B2 (en) 2005-05-06 2011-06-07 Medtronic Minimed, Inc. Needle inserter and method for infusion device
US20060253085A1 (en) 2005-05-06 2006-11-09 Medtronic Minimed, Inc. Dual insertion set
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
EP1898975A2 (en) 2005-05-13 2008-03-19 Novo Nordisk A/S Medical device adapted to detect disengagement of a transcutaneous device
WO2006125692A1 (en) 2005-05-26 2006-11-30 Novo Nordisk A/S A dosing operation in a medical device
US7387607B2 (en) 2005-06-06 2008-06-17 Intel Corporation Wireless medical sensor system
US7819840B2 (en) 2005-06-06 2010-10-26 C. R. Bard, Inc. Feeding device including balloon tip and method of manufacture
US20090212966A1 (en) 2005-06-27 2009-08-27 Novo Nordisk A/S User Interface for Delivery System Providing Dual Setting of Parameters
WO2007000426A2 (en) 2005-06-27 2007-01-04 Novo Nordisk A/S User interface for delivery system providing shortcut navigation
CN101208700A (zh) 2005-06-27 2008-06-25 诺沃-诺迪斯克有限公司 提供分布曲线图形编程的输送系统的用户接口
CA2616128C (en) * 2005-07-22 2011-05-31 Medtronic, Inc. Miniature pump for drug delivery
EP1922050A2 (en) * 2005-08-08 2008-05-21 Eli Lilly And Company Assembly for filling a container of a delivery device with a pharmaceutical
US20070060869A1 (en) * 2005-08-16 2007-03-15 Tolle Mike C V Controller device for an infusion pump
US20090227855A1 (en) * 2005-08-16 2009-09-10 Medtronic Minimed, Inc. Controller device for an infusion pump
US20070060870A1 (en) * 2005-08-16 2007-03-15 Tolle Mike Charles V Controller device for an infusion pump
PL1762259T3 (pl) 2005-09-12 2011-03-31 Unomedical As Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową
WO2007035563A2 (en) * 2005-09-19 2007-03-29 Lifescan, Inc. Malfunction detection via pressure pulsation
DE202005014958U1 (de) * 2005-09-22 2005-12-08 Dieter Hölzle Technik-Projekte GmbH Injektionsvorrichtung
US8409142B2 (en) 2005-09-26 2013-04-02 Asante Solutions, Inc. Operating an infusion pump system
US8545445B2 (en) * 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
JP2007097009A (ja) 2005-09-30 2007-04-12 Sony Corp データ転送システム,送信端末,受信端末,およびそのプログラム,データ送信方法,データ受信方法
US7787678B2 (en) 2005-10-07 2010-08-31 Siemens Corporation Devices, systems, and methods for processing images
US20070133736A1 (en) 2005-10-17 2007-06-14 Siemens Corporate Research Inc Devices, systems, and methods for imaging
WO2007047279A1 (en) 2005-10-18 2007-04-26 Richards Cynthia C Dispenser having a first pump for insulin and a second pump for glucose or glucagon
US7535357B2 (en) * 2005-10-31 2009-05-19 Olusola Enitan Proximity alarm system for articles
US7935104B2 (en) * 2005-11-07 2011-05-03 Medingo, Ltd. Systems and methods for sustained medical infusion and devices related thereto
US9028467B2 (en) * 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US7922971B2 (en) 2005-11-30 2011-04-12 Abbott Diabetes Care Inc. Integrated meter for analyzing biological samples
JP4573762B2 (ja) 2005-11-30 2010-11-04 本田技研工業株式会社 内燃機関の潤滑装置
US8108048B2 (en) * 2005-11-30 2012-01-31 Medtronic, Inc. Protocol implementation for telemetry communications involving implantable medical devices
JP2007207106A (ja) 2006-02-03 2007-08-16 Ascii Solutions Inc 置き忘れ・盗難防止システム
US11318249B2 (en) * 2006-02-09 2022-05-03 Deka Products Limited Partnership Infusion pump assembly
US8579884B2 (en) 2006-02-09 2013-11-12 Deka Products Limited Partnership Infusion pump assembly
EP1997234A1 (en) 2006-03-13 2008-12-03 Novo Nordisk A/S Medical system comprising dual purpose communication means
US20070255227A1 (en) * 2006-04-27 2007-11-01 Haase James M Methods and apparatus for refilling an infusion device
US7942844B2 (en) * 2006-04-28 2011-05-17 Medtronic Minimed, Inc. Remote monitoring for networked fluid infusion systems
US20070255126A1 (en) * 2006-04-28 2007-11-01 Moberg Sheldon B Data communication in networked fluid infusion systems
US7539532B2 (en) 2006-05-12 2009-05-26 Bao Tran Cuffless blood pressure monitoring appliance
US7432637B2 (en) * 2006-07-28 2008-10-07 Neuberg Company Limited Piezoelectric drive device and liquid discharging device
US20080160492A1 (en) 2006-08-08 2008-07-03 Insulet Corporation Interactive training system and method
US7677275B2 (en) * 2006-08-14 2010-03-16 John Witte One hand syringe filling device
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7789857B2 (en) * 2006-08-23 2010-09-07 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
EP2086851B1 (en) * 2006-11-13 2013-06-05 Raymond John Baker Closure and dispensing system
US7938801B2 (en) 2006-11-22 2011-05-10 Calibra Medical, Inc. Disposable infusion device filling apparatus and method
US8352041B2 (en) 2006-11-28 2013-01-08 The Alfred E. Mann Foundation For Scientific Research Remote controls and ambulatory medical systems including the same
SI2125077T1 (en) * 2006-12-22 2018-06-29 F. Hoffmann - La Roche Ag SYSTEMS AND DEVICES FOR PERMANENT SUPPLY OF THERAPEUTIC FLUID
US8057426B2 (en) 2007-01-03 2011-11-15 Medtronic Vascular, Inc. Devices and methods for injection of multiple-component therapies
EP2121077A1 (en) * 2007-02-09 2009-11-25 Deka Products Limited Partnership Automated insertion assembly
JP5102350B2 (ja) * 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド リザーバ充填/気泡管理/注入媒体送給システムおよび該システムを用いる方法
US7981102B2 (en) 2007-05-21 2011-07-19 Asante Solutions, Inc. Removable controller for an infusion pump
US7892199B2 (en) 2007-05-21 2011-02-22 Asante Solutions, Inc. Occlusion sensing for an infusion pump
CA2689711C (en) * 2007-05-31 2016-11-15 Teijin Pharma Limited Ultrasonic apparatus and method for measuring the concentration of gas
US8449523B2 (en) 2007-06-15 2013-05-28 Animas Corporation Method of operating a medical device and at least a remote controller for such medical device
US8932250B2 (en) 2007-06-15 2015-01-13 Animas Corporation Systems and methods to pair a medical device and a remote controller for such medical device
US8103228B2 (en) * 2007-07-12 2012-01-24 Qualcomm Incorporated Method for determining line-of-sight (LOS) distance between remote communications devices
US8241265B2 (en) 2007-08-01 2012-08-14 Hospira, Inc. Medicament admixing system
US7744287B2 (en) 2007-09-05 2010-06-29 Adc Telecommunications, Inc. Connector enclosure
WO2009060419A2 (en) 2007-11-08 2009-05-14 Elcam Medical A.C.A..L. Ltd Vial adaptor and manufacturing method therfor
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
CN114796703A (zh) 2007-12-31 2022-07-29 德卡产品有限公司 输注泵组件
GB2458139A (en) * 2008-03-06 2009-09-09 Toumaz Technology Ltd Monitoring and tracking of wireless sensor devices in a healthcare monitoring system
DK2271384T3 (en) 2008-03-10 2018-05-22 Hoffmann La Roche PORTABLE INFUSION AND DETECTION DEVICE WITH BATTERY CHARGING AND DATA TRANSMISSION MECHANISMS
JP2011519695A (ja) 2008-05-08 2011-07-14 リプレニッシュ パンプス, エルエルシー 植設可能な薬物送達デバイスおよびそのデバイスを充填する装置および方法
EP2301089A1 (en) 2008-06-09 2011-03-30 Danfoss Polypower A/S A transducer comprising a composite material and method of making such a composite material
US20090322513A1 (en) * 2008-06-27 2009-12-31 Franklin Dun-Jen Hwang Medical emergency alert system and method
EP2141605A1 (en) 2008-07-01 2010-01-06 Thomson Licensing Method and device to perform direct memory access
US8604923B1 (en) * 2008-07-16 2013-12-10 Victor Rivas Alvarez Telemetric health monitoring devices and system
US8671994B2 (en) * 2008-09-05 2014-03-18 Inter-Med, Inc. Syringe filling apparatus
JP6288903B2 (ja) * 2008-09-15 2018-03-07 デカ・プロダクツ・リミテッド・パートナーシップ 流体送達のためのシステムおよび方法
US8588925B2 (en) * 2009-07-06 2013-11-19 Boston Scientific Neuromodulation Corporation External device for an implantable medical system having accessible contraindication information
JP5333850B2 (ja) 2009-07-15 2013-11-06 ニプロ株式会社 連結器具
EP3284494A1 (en) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Portable infusion pump system
JP3155758U (ja) 2009-08-24 2009-12-03 株式会社 ミクロ ゴルフ及び野球のスイング練習具
US20110144614A1 (en) 2009-12-11 2011-06-16 Robert Hereford Syringe guide and associated methods
US8613724B2 (en) 2009-12-31 2013-12-24 DEKA Products Limted Partnership Infusion pump assembly
US20120000569A1 (en) 2010-07-01 2012-01-05 Wiegel Christopher D Reservoir filling aid for a medical pump
BR112013011033A2 (pt) * 2010-11-08 2016-09-13 Koninkl Philips Electronics Nv dispositivo médico sem fios, rede de área de paciente sem fios, método para uma rede de área de paciente e método para a transmissão de forma sem fios de informações médicas
US20130157571A1 (en) * 2011-12-19 2013-06-20 Dene Robert Iliff System for wireless remote monitoring of alarm events of a medical device and corresponding patient
US8761717B1 (en) * 2012-08-07 2014-06-24 Brian K. Buchheit Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate
DE102012020945B4 (de) * 2012-10-25 2019-10-10 Fresenius Medical Care Deutschland Gmbh Vorrichtung, System und Verfahren zur Überwachung, Informationsanzeige und Bedienung von medizinischen Fluidmanagementgeräten
US10682102B2 (en) * 2013-03-15 2020-06-16 Fenwal, Inc. Systems, articles of manufacture, and methods for multi-screen visualization and instrument configuration
US8983620B2 (en) * 2013-03-15 2015-03-17 Medtronic, Inc. Systems, apparatus and methods facilitating longevity extension for implantable medical devices
US10615642B2 (en) * 2013-11-11 2020-04-07 Tc1 Llc Resonant power transfer systems with communications
TWI541040B (zh) * 2014-04-08 2016-07-11 Bionime Corp Analyte measuring instrument
US10172996B2 (en) * 2014-08-22 2019-01-08 Fenwal, Inc. Medical solution authentication
US20160174857A1 (en) * 2014-12-22 2016-06-23 Eggers & Associates, Inc. Wearable Apparatus, System and Method for Detection of Cardiac Arrest and Alerting Emergency Response
US10543370B2 (en) * 2017-12-22 2020-01-28 Pacesetter, Inc. Method and device to manage modifications of protected registers in an implantable medical device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268640A (en) * 1968-05-31 1972-03-29 Nat Res Dev Acoustic detection apparatus
US4273121A (en) * 1978-02-17 1981-06-16 Andros Incorporated Medical infusion system
US5349852A (en) * 1986-03-04 1994-09-27 Deka Products Limited Partnership Pump controller using acoustic spectral analysis
CN1202248A (zh) * 1995-09-25 1998-12-16 施蓝姆伯格工业公司 流体流速的声学测量方法

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105816943A (zh) * 2015-01-27 2016-08-03 韦贝尔Cds公司 一种无菌条件下给送流体的定量给药装置
CN105816943B (zh) * 2015-01-27 2020-12-01 艾斯曲尔医疗公司 一种无菌条件下给送流体的定量给药装置
CN105943381A (zh) * 2016-05-06 2016-09-21 中国人民解放军第三军医大学第附属医院 三升袋挤压器
CN105943381B (zh) * 2016-05-06 2018-07-20 中国人民解放军第三军医大学第一附属医院 三升袋挤压器
CN109922847A (zh) * 2016-11-01 2019-06-21 赛诺菲-安万特德国有限公司 体积测量组件
US11246984B2 (en) 2016-11-01 2022-02-15 Sanofi-Aventis Deutschland Gmbh Volume measuring arrangement
CN110383041A (zh) * 2017-03-03 2019-10-25 国立大学法人熊本大学 光学测定系统、光学单元以及光学测定方法
CN110383041B (zh) * 2017-03-03 2021-12-21 国立大学法人熊本大学 光学测定系统、光学单元以及光学测定方法
CN112384268A (zh) * 2018-07-11 2021-02-19 生物技术公司 药物输送系统
CN112384268B (zh) * 2018-07-11 2023-03-10 生物技术公司 药物输送系统

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US20130300565A1 (en) 2013-11-14
US8679073B2 (en) 2014-03-25
US20140039395A1 (en) 2014-02-06
EP1993636B2 (en) 2017-03-01
EP2532377A2 (en) 2012-12-12
US20160166764A1 (en) 2016-06-16
US20190365992A1 (en) 2019-12-05
US8414522B2 (en) 2013-04-09
EP2532376A3 (en) 2016-03-09
US20150246177A1 (en) 2015-09-03
US20200261645A1 (en) 2020-08-20
EP2324872A2 (en) 2011-05-25
US20120209240A1 (en) 2012-08-16
US11813427B2 (en) 2023-11-14
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US20160158463A1 (en) 2016-06-09
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US11408414B2 (en) 2022-08-09
US20190201638A1 (en) 2019-07-04
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US8585377B2 (en) 2013-11-19
US20190099560A1 (en) 2019-04-04
US20190022337A1 (en) 2019-01-24
US10709838B2 (en) 2020-07-14
US8113244B2 (en) 2012-02-14
US20190307970A1 (en) 2019-10-10
US11786651B2 (en) 2023-10-17
CA2926975C (en) 2019-10-29
US20140221929A1 (en) 2014-08-07
EP2324872B1 (en) 2013-07-31
JP2014168695A (ja) 2014-09-18
JP2020096888A (ja) 2020-06-25
US20120209204A1 (en) 2012-08-16
US20140025001A1 (en) 2014-01-23
US9724461B2 (en) 2017-08-08
US10975854B2 (en) 2021-04-13
US20120209198A1 (en) 2012-08-16
JP5770706B2 (ja) 2015-08-26
US20120209180A1 (en) 2012-08-16
JP6484404B2 (ja) 2019-03-13
US11491273B2 (en) 2022-11-08
US20170216520A1 (en) 2017-08-03
US8617107B2 (en) 2013-12-31
AU2007212275A1 (en) 2007-08-16
US20220249769A1 (en) 2022-08-11
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US9295780B2 (en) 2016-03-29
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US20170056585A1 (en) 2017-03-02
US20130231608A1 (en) 2013-09-05
US20130303991A1 (en) 2013-11-14
US9248233B2 (en) 2016-02-02
US20210293232A1 (en) 2021-09-23
US11413391B2 (en) 2022-08-16
US20120209186A1 (en) 2012-08-16
US20120209209A1 (en) 2012-08-16
WO2007092618A3 (en) 2007-12-06
US9901689B2 (en) 2018-02-27
JP2014166574A (ja) 2014-09-11
US10995742B2 (en) 2021-05-04
US10245389B2 (en) 2019-04-02
US10716893B2 (en) 2020-07-21
ATE512682T1 (de) 2011-07-15
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US10232131B2 (en) 2019-03-19
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US20120209190A1 (en) 2012-08-16
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US20120209178A1 (en) 2012-08-16
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US9492614B2 (en) 2016-11-15
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US9295779B2 (en) 2016-03-29
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US20180126097A1 (en) 2018-05-10
US9259531B2 (en) 2016-02-16
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US11712513B2 (en) 2023-08-01
US8518000B2 (en) 2013-08-27
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US9895499B2 (en) 2018-02-20
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CN104162201A (zh) 2014-11-26
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WO2007092618A2 (en) 2007-08-16
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US20120209189A1 (en) 2012-08-16
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MX2008010340A (es) 2008-11-18
US10293117B2 (en) 2019-05-21
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US20190262555A1 (en) 2019-08-29

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