CN103735719A - Method for preparing compound coptis root capsule - Google Patents
Method for preparing compound coptis root capsule Download PDFInfo
- Publication number
- CN103735719A CN103735719A CN201410011908.2A CN201410011908A CN103735719A CN 103735719 A CN103735719 A CN 103735719A CN 201410011908 A CN201410011908 A CN 201410011908A CN 103735719 A CN103735719 A CN 103735719A
- Authority
- CN
- China
- Prior art keywords
- coptis root
- hybrid medicine
- mixed medicinal
- rhizoma coptidis
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims abstract description 9
- 235000002991 Coptis groenlandica Nutrition 0.000 title abstract 9
- 241000218202 Coptis Species 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 44
- 239000000843 powder Substances 0.000 claims abstract description 13
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000012856 packing Methods 0.000 claims description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract description 4
- 230000002045 lasting effect Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract description 2
- 244000247747 Coptis groenlandica Species 0.000 abstract 8
- 240000002853 Nelumbo nucifera Species 0.000 abstract 4
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 4
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 4
- 241000405414 Rehmannia Species 0.000 abstract 4
- 238000003801 milling Methods 0.000 abstract 4
- 238000004806 packaging method and process Methods 0.000 abstract 2
- 238000009924 canning Methods 0.000 abstract 1
- 238000010411 cooking Methods 0.000 abstract 1
- 238000001784 detoxification Methods 0.000 abstract 1
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- ZGEFAWWFLHUTII-UHFFFAOYSA-N catalpin Natural products C1C(C23)(O)COC3OC(O)CC2C1OC(=O)C1=CC=C(O)C=C1 ZGEFAWWFLHUTII-UHFFFAOYSA-N 0.000 description 2
- ZGEFAWWFLHUTII-ZNOBHYIQSA-N chembl2332347 Chemical compound O([C@H]1[C@@H]2C[C@H](O[C@@H]3OC[C@]([C@H]23)(O)C1)O)C(=O)C1=CC=C(O)C=C1 ZGEFAWWFLHUTII-ZNOBHYIQSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- XCUCMLUTCAKSOZ-FIRIVFDPSA-N Liensinine Chemical compound C([C@@H]1C=2C=C(C(=CC=2CCN1C)OC)OC=1C(O)=CC=C(C=1)C[C@H]1N(C)CCC=2C=C(C(=CC=21)OC)OC)C1=CC=C(O)C=C1 XCUCMLUTCAKSOZ-FIRIVFDPSA-N 0.000 description 1
- XCUCMLUTCAKSOZ-JSOSNVBQSA-N Liensinine Natural products C([C@@H]1C=2C=C(C(=CC=2CCN1C)OC)OC=1C(O)=CC=C(C=1)C[C@@H]1N(C)CCC=2C=C(C(=CC=21)OC)OC)C1=CC=C(O)C=C1 XCUCMLUTCAKSOZ-JSOSNVBQSA-N 0.000 description 1
- 229930195376 Rehmannioside Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- RJWJHRPNHPHBRN-FKVJWERZSA-N aucubin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2C(CO)=C[C@@H](O)[C@@H]2C=CO1 RJWJHRPNHPHBRN-FKVJWERZSA-N 0.000 description 1
- UTDFQMAXCUGNJR-UHFFFAOYSA-N aucubin Natural products OCC1OC(Oc2ccoc2C3C(O)CCC3O)C(O)C(O)C1O UTDFQMAXCUGNJR-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 150000003836 berberines Chemical group 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 125000004394 rehmannioside group Chemical group 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing a compound coptis root capsule and aims to provide a heat-clearing detoxification medicine with high speed and lasting effect. In a technical scheme adopted by the invention, the compound coptis root capsule is processed according to the procedures of raw material selecting, decocting, milling, baking, milling and packaging. The method for preparing the compound coptis root capsule, disclosed by the invention, is operated according to the following steps: (1) selecting coptis root, rehmannia and lotus plumule, putting the coptis root, the rehmannia and the lotus plumule into a pot, adding water and baking soda, heating and cooking the coptis root, the rehmannia and the lotus plumule; (2) milling the coptis root, the rehmannia and the lotus plumule to obtain mixed medicinal paste; (3) baking the mixed medicinal paste to obtain a dry mixed medicinal block; (4) milling the dry mixed medicinal block to obtain mixed medicinal powder with the granularity being 300-400 meshes; (5) canning the mixed medicinal powder into capsules; and (6) packaging the mixed medicinal powder capsules. The technical scheme adopted by the invention is simple and convenient to operate, and the compound coptis root capsule is not bitter in mouthfeel, easy to digest and absorb and lasting in efficacy.
Description
Technical field
The present invention relates to Chinese patent medicine processing technique.
Background technology
Application number is to disclose a kind of tasteless quick-releasing berberine hydrochloride pellet in 201110451375.6 description, and it is comprised of principal agent berberine hydrochloride, adjuvant, taste masking coating material and adhesive; With accessory drugs, make the base ball core core of micropill, at the coated principal agent berberine hydrochloride layer in the outside of base ball core core, in the outside of principal agent berberine hydrochloride layer, coated taste masking coating material layer.After this berberine hydrochloride micropill is absorbed by the body, in blood the time of staying short, most of in 48 hours, with original shape, discharge, thereby heat-clearing and toxic substances removing weak effect.
Summary of the invention
The invention discloses a kind of compound Rhizoma Coptidis capsules manufacture method, object is to provide a kind of speed soon and the heat-clearing and toxic substances removing medicine of lasting medicine.The technical solution used in the present invention is according to choosing raw material, boiling, grind, oven dry, pulverizing, packaging process are processed.
A kind of compound Rhizoma Coptidis capsules manufacture method disclosed by the invention, follows these steps to operation: (1) is chosen Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis and put into pot, in pot, adds water and sodium bicarbonate, and Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis are boiled in heating; (2) mill Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis, obtains hybrid medicine mud; (3) dry hybrid medicine mud, obtain the dry piece of hybrid medicine; (4) dry hybrid medicine piece is milled into hybrid medicine powder, hybrid medicine powder size is 300-400 orders; (5) canned hybrid medicine Sprinkle Caps; (6) packing hybrid medicine Sprinkle Caps.Choosing Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis is raw material.Rhizoma Coptidis main component is berberine, has eliminating fire and detoxication effect.Radix Rehmanniae contains rehmannioside, dihydro Catalpin, aucubin, Catalpin, has and has nourishing yin effect.Plumula Nelumbinis, containing compositions such as liensinine, isoliensinines, has Qinghuo Jiedu effect.Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis are put into pot, in pot, add water and sodium bicarbonate, Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis are boiled in heating.Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis add after sodium bicarbonate, and wherein effective ingredient is convenient to absorption of human body.With grinding machine the mill Rhizoma Coptidis, Radix Rehmanniae, the Plumula Nelumbinis that boil, obtain hybrid medicine mud.Hybrid medicine mud is put into baking oven, dry hybrid medicine mud, obtain the dry piece of hybrid medicine.Dry hybrid medicine piece is milled into hybrid medicine powder with grinding machine.Hybrid medicine powder size is 300-400 orders, is convenient to like this digest and assimilate.In hybrid medicine powder being incapsulated with capsule can packing machine, make hybrid medicine Sprinkle Caps.Hybrid medicine Sprinkle Caps is packaged into capsule tablets with package packing machine, then capsule tablets is packed in medicine box.
The technical solution used in the present invention is easy and simple to handle, and this compound Rhizoma Coptidis capsules entrance is not bitter, is easy to digest and assimilate, and the efficacy of a drug is lasting.
The specific embodiment
Choosing 10 kilograms of 50 kilograms of Rhizoma Coptidis, 40 kilograms of Radix Rehmanniae, Plumula Nelumbinis is raw material.Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis are put into pot, and to adding 5 kilograms of water and sodium bicarbonate 1 ﹒ in pot, Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis are boiled in heating.With grinding machine the mill Rhizoma Coptidis, Radix Rehmanniae, the Plumula Nelumbinis that boil, obtain hybrid medicine mud.Hybrid medicine mud is put into baking oven, dry hybrid medicine mud, obtain the dry piece of hybrid medicine.Dry hybrid medicine piece is milled into hybrid medicine powder with grinding machine.Hybrid medicine powder size is 300-400 orders.In hybrid medicine powder being incapsulated with capsule can packing machine, make hybrid medicine Sprinkle Caps.Hybrid medicine Sprinkle Caps is packaged into capsule tablets with package packing machine, then capsule tablets is packed in medicine box, shading storage.
Claims (1)
1. a compound Rhizoma Coptidis capsules manufacture method, is characterized in that following these steps to operation: (1) is chosen Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis and put into pot, in pot, adds water and sodium bicarbonate, and heating boils Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis; (2) mill Rhizoma Coptidis, Radix Rehmanniae, Plumula Nelumbinis, obtains hybrid medicine mud; (3) dry hybrid medicine mud, obtain the dry piece of hybrid medicine; (4) dry hybrid medicine piece is milled into hybrid medicine powder, hybrid medicine powder size is 300-400 orders; (5) canned hybrid medicine Sprinkle Caps; (6) packing hybrid medicine Sprinkle Caps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410011908.2A CN103735719A (en) | 2014-01-12 | 2014-01-12 | Method for preparing compound coptis root capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410011908.2A CN103735719A (en) | 2014-01-12 | 2014-01-12 | Method for preparing compound coptis root capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103735719A true CN103735719A (en) | 2014-04-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410011908.2A Pending CN103735719A (en) | 2014-01-12 | 2014-01-12 | Method for preparing compound coptis root capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103735719A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352832A (en) * | 2014-10-13 | 2015-02-18 | 天津瑞贝特科技发展有限公司 | Pharmaceutical composition for treating bovine laminitis and preparation method of pharmaceutical composition |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030124206A1 (en) * | 2001-12-21 | 2003-07-03 | Shuenn-Jyi Sheu | Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same |
| CN102441064A (en) * | 2011-12-27 | 2012-05-09 | 西南大学 | Traditional Chinese medicine composition for treating diabetes and preparation thereof |
| CN102552518A (en) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | Application of four traditional Chinese medicines in relieving liver and kidney toxicity |
| CN102631526A (en) * | 2011-02-14 | 2012-08-15 | 王宇红 | Chinese medicinal composition for treating diabetes mellitus |
| WO2013176327A1 (en) * | 2012-05-25 | 2013-11-28 | 한국한의학연구원 | Pharmaceutical composition and health functional food for preventing or treating bone diseases, containing lactic acid bacteria fermentation product of detox soup of coptis chinensis as active ingredients |
-
2014
- 2014-01-12 CN CN201410011908.2A patent/CN103735719A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030124206A1 (en) * | 2001-12-21 | 2003-07-03 | Shuenn-Jyi Sheu | Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same |
| CN102631526A (en) * | 2011-02-14 | 2012-08-15 | 王宇红 | Chinese medicinal composition for treating diabetes mellitus |
| CN102441064A (en) * | 2011-12-27 | 2012-05-09 | 西南大学 | Traditional Chinese medicine composition for treating diabetes and preparation thereof |
| CN102552518A (en) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | Application of four traditional Chinese medicines in relieving liver and kidney toxicity |
| WO2013176327A1 (en) * | 2012-05-25 | 2013-11-28 | 한국한의학연구원 | Pharmaceutical composition and health functional food for preventing or treating bone diseases, containing lactic acid bacteria fermentation product of detox soup of coptis chinensis as active ingredients |
Non-Patent Citations (3)
| Title |
|---|
| 何锦婷，等: "莲子心的现代临床应用", 《长春中医药大学学报》 * |
| 国家药典委员会: "《中华人民共和国药典：2010年版. 一部》", 31 January 2010, 中国医药科技出版社 * |
| 郭美珠，等: "滋肾清胃法在消渴病种的运用", 《中医药信息》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352832A (en) * | 2014-10-13 | 2015-02-18 | 天津瑞贝特科技发展有限公司 | Pharmaceutical composition for treating bovine laminitis and preparation method of pharmaceutical composition |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140423 |