CN103721337B - With intravascular guidewire catheter and method for manufacturing the push - Google Patents

With intravascular guidewire catheter and method for manufacturing the push Download PDF

Info

Publication number
CN103721337B
CN103721337B CN 201210393570 CN201210393570A CN103721337B CN 103721337 B CN103721337 B CN 103721337B CN 201210393570 CN201210393570 CN 201210393570 CN 201210393570 A CN201210393570 A CN 201210393570A CN 103721337 B CN103721337 B CN 103721337B
Authority
CN
Grant status
Grant
Patent type
Prior art keywords
catheter
layer
guide wire
wire
helical
Prior art date
Application number
CN 201210393570
Other languages
Chinese (zh)
Other versions
CN103721337A (en )
Inventor
徐世云
张琳琳
唐智荣
罗七
罗七一
杨海
Original Assignee
上海微创医疗器械(集团)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0009Making of catheters or other medical or surgical tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0062Catheters; Hollow probes characterised by structural features having features to improve the sliding of one part within another by using lubricants or surfaces with low friction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0183Rapid exchange or monorail catheters

Abstract

本发明提供配合导丝进行血管内推送的导管及其制造方法。 The present invention provides a catheter with a guide wire and a manufacturing method for push blood vessel. 导管的内壁具有螺旋层。 A catheter having a spiral inner wall layer. 在沿导丝推送导管时,在保证导丝运动方向的同时,大大减少导丝和导管的配合面积,降低导管内壁与导丝的摩擦力,增加导管的可推送性。 When the pusher catheter along the guide wire, the guide wire in the direction of movement guaranteed while greatly reducing the guidewire and catheter fitting area, reduce friction with the inner wall of the catheter guide wire, increasing the pushability of the catheter.

Description

配合导丝进行血管内推送的导管及其制造方法 With intravascular guidewire catheter and method for manufacturing the push

技术领域 FIELD

[0001]本发明涉及导管,特别是涉及动脉血管内与导丝配合推送的导管。 [0001] The present invention relates to catheters, and more particularly to fit within the artery and the guidewire push catheter.

背景技术 Background technique

[0002]在利用介入性方法治疗冠心病的手术中,经皮穿刺腔内冠状动脉成形术(Percutaneous Transluminal Coronary Ang1plasty;PTCA)结合支架植入,使狭窄的冠状动脉管腔变大,血流增加,供血改善。 [0002] In the surgical treatment of coronary heart disease by using interventional methods, percutaneous transluminal coronary angioplasty (Percutaneous Transluminal Coronary Ang1plasty; PTCA) binding stenting, coronary artery lumen narrowing becomes large, increasing blood flow , improve blood supply.

[0003]冠脉支架植入的具体过程简略为:经皮穿刺股动脉或桡动脉,将造影导丝逆行经主动脉送至主动脉根部冠状动脉的开口处,沿着导丝送入造影导管,退出导丝,进行造影,造影完毕,退出造影导管,再进入造影导丝,顺着导丝进入导引导管,退出造影导丝,进入光滑导引导丝,沿着导引导管内送至冠脉入口处,出导管后进入冠状动脉。 [0003] DETAILED coronary stent implantation is a schematic process: percutaneous femoral artery or radial artery, the angiography guide wire retrograde through the aortic root to the opening of the aortic artery, the angiography catheter over the guidewire into the exit guide wire, a contrast, a contrast is completed, exit angiography catheter, angiography guide wire re-entry, into the guiding catheter along the guide wire, the guide wire exit contrast, enters the smooth guide wire, along the inner guide catheter to the coronary entrance, the catheter into the coronary arteries. 再将带支架的球囊导管套于导丝上,位于导引导管腔内,送至冠脉病灶处,对支架内的球囊灌注一定压力的造影液充盈,撑开支架,并固定支架于病灶狭窄部位。 Then stented balloon catheter over the guide wire to the sleeve, located in the guide catheter lumen, to the coronary artery lesions, balloon within the stent constant pressure perfusion contrast medium filling, distraction holder, and is fixed to the bracket lesion stenosis.

[0004]传统上,与光滑导丝配合的输送导管的内壁是光滑结构,在包裹着光滑导丝推送至病变部位时候,尤其通过血管弯曲部位时候,摩擦阻力比较大。 [0004] Conventionally, with the smooth inner wall of the guidewire delivery catheter is smooth mating structure, wrapped in a smooth guide wire to the lesion, when pushed, in particular through a blood vessel bent portion when a relatively large frictional resistance.

[0005] 为了减小摩擦阻力,可以在导丝表面增加不连续结构处理。 [0005] In order to reduce the frictional resistance can be increased discontinuity surface treatment guidewire. 但是,不连续结构处理可能会导致如下缺陷: However, handling discontinuities may cause the following drawbacks:

[0006] 1.在沿着导丝推送入球囊扩张导管时,狭窄开口的导管tip头(即导管的远端)在推送过程中有可能被卡在导丝表面不连续处,导致推送困难; [0006] 1. pushed into the balloon dilation catheter along the guide wire, catheter tip over a narrow opening (i.e., the distal end of the catheter) is possible in the process of being stuck in the push wire surface discontinuity, leading to difficulties in the push ;

[0007] 2.在将导丝插入病变部位的过程中,当导丝头部出了导管口,进入病变部位,如狭窄冠脉时候,其表面突起状或不连续结构可能增加推进阻力,甚至血管组织损伤而导致并发问题。 [0007] 2. the guide wire into the lesion in the process, when the head of a guide wire conduit opening into the lesion, such as a coronary artery stenosis, when a surface or discontinuity protruding advancing resistance may increase, or even vascular tissue damage caused by concurrency issues.

[0008]中国实用新型专利CN2824973Y公开了一种医用导丝。 [0008] The Chinese utility model patent CN2824973Y discloses a medical guide wire. 该医用导丝将传统的圆形导丝截面改变为三角形、五角形、六边形、星形等,甚至是在导丝上有螺纹结构,目的是用来降低导管导丝的配合面积,从而降低摩擦力。 The medical guide wire to a conventional circular cross-section is changed to the guidewire triangular, pentagonal, hexagonal, star-like, or even be threaded over a guidewire structure, with the aim to reduce the area of ​​the catheter guide wire, thereby reducing friction. 但是,考虑到导丝在血管中,出了造影导管后,将要在病变部位直接推进一段,而往往该部位本身就狭窄,则导丝表面的改变有增加损伤血管的可能。 However, after taking into account the guidewire in the vessel, the catheter angiography, will advance directly to the lesion in the period, while the site itself is often narrow, changing the surface of the guide wire may increase the damage of blood vessels.

[0009] 美国专利US6849062B2公开了一种用于球囊导管的导管轴。 [0009] U.S. Patent No. US6849062B2 discloses a catheter for a balloon catheter shaft. 该导管轴将传统的光滑导管改变为星形,在导管轴的内圆周上存在多条(至少4条)突起纹路,所述多条突起纹路直线贯穿整个导管轴长度,目的也是减少与导丝的接触面积。 The catheter shaft of the catheter to change the traditional smooth a star, there are multiple (at least four) of the projecting lines on the inner circumference of the catheter shaft, the plurality of straight lines throughout the projection length of the catheter shaft, the purpose is to reduce the guidewire contact area. 但其缺点在于: But its disadvantage is that:

[0010] 1.所述多条突起纹路直线贯穿整个导管轴长度,导丝与导管轴之间的接触仍然为连续线接触,因为需要多条突起纹路来限制导丝的运动范围,从而增加了摩擦; [0010] 1. The straight lines of the plurality of projections throughout the length of the catheter shaft, the contact between the guidewire and the catheter shaft remains continuous line contact, the plurality of projection lines because of the need to limit the range of motion of the guide wire, thereby increasing the friction;

[0011 ] 2.在弯曲部位,导丝有可能增加与突起的接触,摩擦力仍然会很大。 [0011] 2. In the bent portion, it is possible to increase the guidewire into contact with the projections, the friction will still be significant.

发明内容 SUMMARY

[0012]本发明的目的是提供一种配合导丝进行血管内推送的导管及其制造方法,在沿导丝推送该导管时,在保证导丝运动方向的同时,大大减少导丝和导管的配合面积,在导管推进过程中,降低导管内壁与导丝的摩擦力,增加导管的可推送性。 [0012] The object of the present invention is to provide a guidewire with a catheter and method for manufacturing intravascular push when pushing the catheter along the guide wire, the guide wire in the direction of movement guaranteed while greatly reducing the guidewire and catheter mating area, the catheter is advanced process, reduce friction with the inner wall of the catheter guide wire, increasing the pushability of the catheter.

[0013]本发明提供一种配合导丝进行血管内推送的导管,其中:所述导管的内壁具有螺旋层;所述螺旋层的硬度大于所述导管的硬度;其特征在于根据以下公式选择所述螺旋层的螺距L: [0013] The present invention provides a push fit guidewire intravascular catheter, wherein: the inner wall of the duct has a helical layer; hardness greater than the hardness of the helical layer of the catheter; characterized by the formula selected according to the pitch of said helical layer L:

[0014] L< = 2*sqrt(3r'2+2R*r) [0014] L <= 2 * sqrt (3r'2 + 2R * r)

[0015]其中r是导丝半径,R是所述导丝的最小弯曲半径,且所述螺旋层的在所述导管的径向方向上的高度取为r。 [0015] where r is the wire radius, R is the minimum bend radius of the guide wire, and the height in the radial direction of the catheter helical layer is taken as r.

[0016]由于所述导管的内壁具有螺旋层,导丝与导管之间的接触为非连续线接触或点接触,在沿导丝推送该导管时,在保证导丝运动方向的同时,大大减少导丝和导管的配合面积,在导管推进过程中,降低导管内壁与导丝的摩擦力,增加导管的可推送性。 [0016] Since the inner wall of the conduit having a contact between the helical layers, the guide wire and catheter as a discontinuous line contact or point contact, when pushing the catheter along the guide wire, the guide wire in the direction of movement guaranteed while greatly reducing the area with the catheter and guidewire, the catheter is advanced in the process, the inner wall of the conduit to reduce friction with the guide wire, increasing the pushability of the catheter. 根据该公式选择所述螺旋层的螺距L,处于最大弯曲状态的导丝能接触所述螺旋层的两个相邻螺牙的顶部而不是仅接触位于所述两个相邻螺牙之间的谷部,从而使处于最大弯曲状态的导丝与导管形成稳定的三点接触,以平稳地引导导管。 According to this formula selected pitch of the helical layer L, in the maximum bent state of the guide wire can be in contact with the top two layers of the helical thread is located adjacent to not only the contact between the thread of the two adjacent valleys, so that the guidewire and the catheter is in the maximum bent state form a stable three-point contacts, in order to smoothly guide catheter. 但是螺距L也不宜过小,因为螺距L过小则螺旋圈数增加,接触面积增加,摩擦增大。 However, the pitch L should not be too small, because the increase in L is too small, the number of turns the spiral pitch, the contact area increases, increased friction.

[0017]同时,本发明改变的是导管的内腔面结构(面向导丝的一侧),与通过改变导丝表面来减少配合面积而减小摩擦力的方法相比,在推进中将更不容易发生额外阻力。 [0017] Also, the present invention is to change the surface structure of the catheter lumen (side surface of the guide wire), and by changing the surface of the guidewire to reduce friction with the reduced area compared with a method in advance in greater additional resistance does not easily occur.

[0018]所述螺旋层可以分布在所述导管的两端之间的任意区域中。 [0018] The helical layer may be distributed in an arbitrary region between the two ends of the catheter. 优选地,所述螺旋层分布覆盖所述导管的全部长度,这样,即使有卡住导丝的情况发生,也是在体外导丝开始端而不是体内,将更容易调整。 Preferably, said helical layer covers the entire length of said distribution conduit, so that, even if there occurs jammed guide wire, the guide wire is in vitro but not in vivo starting end, it will be easier to adjust. 例如,在快速交换式球囊导管中,因为导管长度较短,在手术中,在体外安装导管于导丝上后,导丝将从球囊导管的导丝口穿出,在推送过程中,光滑导丝与导管的配合将一直保持而不会有改变,不会再对导管有额外阻碍发生。 For example, in a rapid exchange balloon catheter, as a short length of the conduit, in surgery, in vitro mounted on the catheter over the guidewire after the guidewire from the balloon catheter guide wire port piercing, during the push, with smooth guidewire and catheter will remain without the change, there will not be additional catheter obstruction occurred.

[0019]优选地,所述螺旋层的与所述导丝接触的表面朝向所述导丝突起,从而进一步减少导丝与导管的接触面积。 [0019] Preferably, the surface in contact with the guide wire of the helical layer projecting toward the guidewire, thereby further reducing the contact area between the guidewire and catheter. 更优选地,所述螺旋层的朝向所述导丝突起的末端的在所述导管的轴向方向上的剖面呈弧形或点状,从而导丝与导管之间的接触为点接触,更进一步减少了导丝与导管的接触面积。 Toward More preferably, the cross-sectional layer of the spiral protrusion of the end of the guidewire in the axial direction of the catheter or curved point, so that the contact between the guidewire and the catheter point contact, more further reducing the contact area between the guidewire and catheter. 在所述螺旋层的朝向所述导丝突起的末端的在所述导管的轴向方向上的剖面呈弧形的情况下,所述螺旋层不容易磨损脱落。 In the case of the cross section toward the guide wire helical layer protrusions in the axial direction of the tip of the catheter is curved, said helical layer is not easily wear off.

[0020]所述螺旋层的剖面在所述导管的轴向方向上的宽度不受限制,只要该宽度保证与导管内壁结合固定良好即可。 [0020] The cross-sectional width of the helical layer is not limited in the axial direction of the catheter, so long as the combined width ensure good fixing to the inner wall of the conduit. 但是,优选地,所述螺旋层的剖面在所述导管的轴向方向上的宽度朝向所述导丝逐渐变小。 However, preferably, a cross-sectional width of said helical layer in the axial direction of the catheter toward the guidewire becomes gradually smaller. 这样能够降低卡住导丝的可能。 This can reduce the possibility of jamming of the guidewire. 更优选地,所述螺旋层的剖面形状大致为弧形、三角形、梯形或其它多边形。 More preferably, the cross-sectional shape of the coil layer is substantially arcuate, triangular, trapezoidal or other polygonal.

[0021]优选地,所述螺旋层与所述导丝接触的表面具有用于减少摩擦的涂层。 [0021] Preferably, the spiral surface layer in contact with the guide wire has a coating for reducing friction. 更优选地,所述涂层可以包括有机硅;所述涂层可以包括亲水性有机物或疏水性有机物。 More preferably, the coating may comprise silicone; the organic coating can comprise a hydrophilic or hydrophobic organic material. 更进一步优选地,所述疏水性有机物包括聚四氟乙烯(PTFE)或聚对二甲苯(PARYLENE)。 Still more preferably, the hydrophobic organic material comprises polytetrafluoroethylene (PTFE) or parylene (PARYLENE).

[0022]所述螺旋层的在所述导管的径向方向上的高度不受限制,但优选略小于所述导丝的半径。 [0022] The height of the helical layer is not limited in the radial direction of the conduit, but preferably is slightly less than the radius of the guidewire.

[0023]优选地,所述螺旋层由硬质材料制成。 [0023] Preferably, the helical layer is made of a hard material. 更优选地,所述硬质材料是高分子材料或金属材料。 More preferably, the hard material is a polymer material or metal material. 进一步优选地,所述硬质材料是工程塑料或合金。 Further preferably, the hard material is a plastic or an alloy. 更进一步优选地,所述合金是不锈钢或镍钛合金。 Still more preferably, the alloy is a stainless steel or nickel titanium alloy. 更进一步优选地,所述工程塑料是聚酰胺或聚酯。 Still more preferably, the plastic is a polyamide or a polyester.

[0024]本发明还提供一种制造上述的配合导丝进行血管内推送的导管的方法,所述方法包括:制备中空管状基材,所述中空管状基材用作导管本体;制作螺旋状操作丝,所述操作丝的螺旋外径与所述中空管状基材的内径相匹配,所述操作丝的外侧具有凹槽,且所述操作丝在轴向方向上的长度大于所述中空管状基材的长度;制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝能够被嵌入到所述凹槽中;将所述螺旋层丝嵌入到所述凹槽中;将所述螺旋层丝的从所述凹槽暴露的底部涂上粘合剂;将嵌入有所述螺旋层丝的所述操作丝置入所述中空管状基材的内侧;以及使所述螺旋层丝的所述底部与所述中空管状基材的内侧表面粘合牢固。 [0024] The present invention further provides a method of manufacturing a guidewire with the above-described push intravascular catheter, the method comprising: preparing hollow tubular substrate, the substrate is used as the hollow tubular catheter body; production operation spiral the outer diameter of the coil wire, the operation wire matches the inner diameter of the hollow substrate tube, outside of the operation wire has a recess, and the operation wire length in the axial direction is larger than the hollow tubular base the length of the material; prepared helical layer wire, the helical layer is dimensioned such that filaments of said helical layer filaments can be embedded in the groove; helical layer embedding the wire into the recess; the said helical layer filaments coated with adhesive from the exposed bottom of the groove; the operation wire embedded with said inner helical layer filaments into said hollow tubular substrate; and the helical layer filaments the bottom inside surface of the hollow tubular substrate is strongly bonded.

[0025]本发明还提供另一种制造上述的配合导丝进行血管内推送的导管的方法,所述方法包括:制备中空管状基材,所述中空管状基材用作导管本体;制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝的螺旋外径小于等于所述中空管状基材的内径;将所述螺旋层丝置入所述中空管状基材的内侧;通过热作用,将所述中空管状基材包覆于所述螺旋层丝上,所述螺旋层丝嵌入所述中空管状基材的深度小于所述螺旋层丝的直径。 Method [0025] The present invention further provides another method of manufacturing the above-described push with the guidewire intravascular catheter, the method comprising: preparing hollow tubular substrate, the substrate is used as the hollow tubular catheter body; production helical layer wire, said helical layer filaments dimensioned such that the outer diameter of the helical wire coil layer is less than or equal to the inner diameter of the hollow tubular substrate; wire into the helical inner layer of the hollow tubular substrate; by heat, the hollow tubular substrate layer is coated on the filament coil, the depth of the helical layer is inset into the hollow tubular substrate is less than the diameter of the coil wire layer.

附图说明 BRIEF DESCRIPTION

[0026]图1(a)是根据本发明的配合导丝进行血管内推送的导管的透视图。 [0026] FIG. 1 (a) is a perspective view of an intravascular catheter in accordance with the push of a guide wire of the present invention.

[0027]图1(b)、图1(c)、图1(d)是该导管的局部剖视图,分别示出大致呈弧形、三角形、梯形的螺旋层剖面形状。 [0027] FIG. 1 (b), FIG. 1 (c), FIG. 1 (d) is a partial sectional view of the conduit, respectively, illustrating a substantially arcuate cross-sectional shape, triangular, trapezoidal helical layer.

[0028]图2是对螺旋层的螺距的最大值进行计算的示意图。 [0028] FIG. 2 is a schematic diagram of the maximum value of the pitch of the helical layer is calculated.

[0029]图3(a)是应用本发明后的快速交换式球囊导管的局部透视图。 [0029] FIG. 3 (a) is a partial perspective view of a rapid exchange balloon catheter of the present invention is applied.

[0030]图3(b)、图3(c)、图3(d)是该快速交换式球囊导管的内管(即本发明的导管)的局部剖视图,分别示出大致呈弧形、三角形、梯形的螺旋层剖面形状。 [0030] FIG. 3 (b), FIG. 3 (c), FIG. 3 (d) is a partial sectional view of the rapid exchange balloon catheter inner tube (i.e., the catheter of the present invention), show a generally arcuate, triangular, trapezoidal cross-sectional shape of the helical layer.

[0031 ]图4是该球囊导管的总体示意图。 [0031] FIG. 4 is an overall schematic view of the balloon catheter.

[0032] 附图标记说明 [0032] REFERENCE NUMERALS

[0033] I 导丝 [0033] I guidewire

[0034] 2 导管 [0034] The duct 2

[0035] 3螺旋层 [0035] The helical layer 3

[0036] 4 导丝口 [0036] 4 guide wire port

[0037] 5 远外管 [0037] The distal outer tube 5

[0038] 6造影液腔 [0038] Contrast liquid chamber 6

[0039] 7 Tip头 [0039] 7 Tip head

[0040] R导丝最小弯曲半径[0041 ] r 导丝半径 [0040] R guidewire minimum bending radius [0041] r the radius of the guidewire

[0042] L 螺距 [0042] L Pitch

具体实施方式 detailed description

[0043]参见图1、3、4,根据本发明的导管2用作球囊导管或导引导管等导管的内管,该导管2配合导丝I进行血管内推送,在该导管2的内壁具有螺旋层3。 [0043] Referring to FIG. 1, 3,4, 2 according to the present invention is used as a catheter balloon catheter or introducer catheter of the catheter inner tube, with the conduit 2 for pushing the guidewire I intravascular inner wall of the conduit 2 3 having helical layer.

[0044]由于所述导管2的内壁具有螺旋层3,导丝I与导管2之间的接触为非连续线接触或点接触,在沿导丝I推送该导管2时,在保证导丝运动方向的同时,大大减少导丝I和导管2的配合面积,在导管2推进过程中,降低导管2内壁与导丝I的摩擦力,增加导管2的可推送性。 [0044] Since the inner wall of the conduit 2 having a spiral layer 3, the contact between the guidewire and the catheter I discontinuous line contact or point contact, when I pushed along the guide wire of the catheter 2, the guide wire movement to ensure Meanwhile direction, greatly reducing the guidewire and catheter fitting area I 2, the process of advancing the catheter 2, the inner wall 2 to reduce friction with the guide wire catheter I, increasing the pushability catheter 2.

[0045]同时,本发明改变的是导管2的内腔面结构(面向导丝I的一侧),与通过改变导丝I表面来减少配合面积而减小摩擦力的方法相比,在推进中将更不容易发生额外阻力。 [0045] Also, the present invention is to change the catheter lumen surface structure 2 (plane I side of the guide wire), the frictional force is reduced compared with the method by varying the guidewire to reduce the surface area of ​​engagement I, advancing in additional resistance will be less likely to occur.

[0046]所述螺旋层3可以分布在所述导管2的导丝口端(即离导丝口 4较近的一端)至导管的tip头7(即所述导管2的离导丝口4较远的另一端)之间的任意区域中。 [0046] The helical layer 3 may be distributed in the outlet end of the guide wire catheter 2 (i.e., from the end close to the guide wire port 4) to the tip of the catheter head 7 (i.e., away from the guide wire port 4 of the tube 2 an arbitrary region between the other end distant) in. 优选地,所述螺旋层3分布覆盖所述导管2的全部长度,这样,即使有卡住导丝I的情况发生,也是在体外导丝I开始端而不是体内,将更容易调整。 Preferably, the helical profile cover layer 3 of the catheter 2 the entire length, so that even if the guidewire is stuck I occurs, the guidewire is in vitro but not in vivo I start end, it will be easier to adjust. 例如,在图3所示的快速交换式球囊导管中,因为导管2长度较短,在手术中,在体外安装导管2于导丝I上后,导丝I将从球囊导管的导丝口4穿出,在推送过程中,光滑导丝I与导管2的配合将一直保持而不会有改变,不会再对导管2有额外阻碍发生。 For example, in a rapid exchange balloon catheter shown in FIG. 3, because the shorter length of the conduit 2, in surgery, in vitro after mounting the catheter on the guide wire 2 I, I guidewire from the balloon catheter guidewire piercing opening 4, in the process of pushing, smooth fit with the catheter guide wire I 2 will remain without the change will not hinder the catheter 2 additional occurrence.

[0047]参见图1(b)、图1(c)、图1(d),优选地,所述螺旋层3的与所述导丝I接触的表面朝向所述导丝I突起,从而进一步减少导丝I与导管2的接触面积。 I surface in contact with the guidewire [0047] Referring to FIG. 1 (b), FIG. 1 (c), FIG. 1 (d), preferably the helical layer 3 toward the guidewire I projections, further I guidewire and the catheter to reduce the contact area 2. 更优选地,所述螺旋层3的朝向所述导丝I突起的末端的在所述导管2的轴向方向上的剖面呈弧形或点状,从而导丝I与导管2之间的接触为点接触,更进一步减少了导丝I与导管2的接触面积。 Toward More preferably, the cross section of the helical layer 3 I guidewire tip projection in the axial direction of the catheter 2 or curved point, so that the contact between the guidewire and the catheter I point contact, further reducing the contact area between the guidewire and the catheter I 2. 在所述螺旋层3的朝向所述导丝I突起的末端的在所述导管2的轴向方向上的剖面呈弧形的情况下,所述螺旋层3不容易磨损脱落。 Arcuate cross section in the case of the helical layer toward the guide wire 3 I protrusions on the catheter tip 2 in the axial direction under the helical layer 3 is not easy to wear off.

[0048]所述螺旋层3的剖面在所述导管2的轴向方向上的宽度不受限制,只要该宽度保证与导管内壁结合固定良好即可。 Cross-sectional [0048] The helical layer 3 of width in the axial direction of the catheter 2 is not limited, so long as the combined width ensure good fixing to the inner wall of the conduit. 但是,优选地,所述螺旋层3的剖面在所述导管2的轴向方向上的宽度朝向所述导丝I逐渐变小。 However, preferably, the helical layer 3 is a cross-sectional width in the axial direction of the catheter 2 towards the guidewire I becomes gradually smaller. 这样能够降低卡住导丝I的可能。 This can reduce the possibility of jamming of the guidewire I. 更优选地,所述螺旋层3的剖面形状大致为弧形、三角形、梯形或其它多边形。 More preferably the cross-sectional shape, said helical layer 3 is substantially arcuate, triangular, trapezoidal or other polygonal. 这里采用表述“大致”是因为所述螺旋层3的剖面形状并非严格要求为弧形、三角形、梯形或其它多边形,例如在图1(c)、图1(d)所示的三角形、梯形剖面形状的顶部可以被圆化为弧形。 Herein employed the expression "substantially" because the cross-sectional shape of the helical layer 3 is not strictly arcuate, triangular, trapezoidal or other polygonal, such as triangular, trapezoidal cross-section in FIG. 1 (c), FIG. 1 (d) shown in FIG. the top may be shaped into a circular arc.

[0049]优选地,所述螺旋层3的与所述导丝I接触的表面具有用于减少摩擦的涂层。 I surface in contact with the guide wire [0049] Preferably, the helical layer 3 having a coating for reducing friction. 更优选地,所述涂层可以包括有机硅;所述涂层可以包括亲水性有机物或疏水性有机物。 More preferably, the coating may comprise silicone; the organic coating can comprise a hydrophilic or hydrophobic organic material. 更进一步优选地,所述疏水性有机物涂层包括聚四氟乙烯(PTFE)或聚对二甲苯(PARYLENE)。 Still more preferably, the hydrophobic organic coating comprises polytetrafluoroethylene (PTFE) or parylene (PARYLENE).

[0050]所述螺旋层3的在所述导管2的径向方向上的高度不受限制,但优选略小于所述导丝I的半径。 [0050] The helical layer 3 of the catheter in height in the radial direction is not limited two, but preferably slightly less than the radius of the guidewire I.

[0051]优选地,可以参照图2对螺旋层3的螺距L的最大值进行计算。 [0051] Preferably, the maximum value of the pitch L in FIG. 2 helical layer 3 is calculated by reference. 为了使处于最大弯曲状态的导丝I仍然能稳定地引导导管2,处于最大弯曲状态的导丝I最好能接触所述螺旋层3的两个相邻螺牙的顶部而不是仅接触位于所述两个相邻螺牙之间的谷部,从而使处于最大弯曲状态的导丝I与导管2形成稳定的三点接触,以平稳地引导导管2。 I order for the guidewire remains in the maximum bent state can be stably guide catheter 2, the maximum bending state in a guidewire I best two layer 3 in contact with the helical thread adjacent to the top instead of being located in contact only said valleys between two adjacent thread so that the guide wire and the catheter I is the maximum bending state of the contact 2 is formed of a stable three-point, 2 to smoothly guide catheter. 图2中所示的螺距L为最大螺距Lmax。 Pitch L shown in FIG. 2 is a maximum pitch Lmax.

[0052] 若导丝I的半径为r,导丝I的最小弯曲半径(即处于最大弯曲状态的导丝I的弯曲半径)为R,且所述螺旋层3的在所述导管2的径向方向上的高度取为r,则根据勾股定理满足下式(I): [0052] (I guidewire bending radius, i.e. in the maximum bent state) if I is the radius of the guide wire minimum bend radius r, the guidewire I is R, and the diameter of the catheter 2 in a helical layer 3 in the height direction is taken as r, then the Pythagorean theorem satisfies the following formula (I):

[0053] (Lmax/2) ~2+(R+r) '2 = (R+2r) '2 (I) [0053] (Lmax / 2) ~ 2 + (R + r) '2 = (R + 2r)' 2 (I)

[0054]根据式(I)进一步推导得出式(2): [0054] According to further derive formula (I) obtained of formula (2):

[0055] Lmax = 2*sqrt(3r~2+2R*;r) (2) [0055] Lmax = 2 * sqrt (3r ~ 2 + 2R *; r) (2)

[0056]换言之,根据以下公式(3)选择所述螺旋层的螺距L: [0056] In other words, (3) selecting the pitch of the helical layer L according to the following formula:

[0057] L< = 2*sqrt(3r'2+2R*r) (3) [0057] L <= 2 * sqrt (3r'2 + 2R * r) (3)

[0058]优选地,所述螺旋层3由硬质材料制成。 [0058] Preferably, the helical layer 3 is made of a hard material. 更优选地,所述硬质材料是高分子材料或金属材料。 More preferably, the hard material is a polymer material or metal material. 进一步优选地,所述硬质材料是工程塑料或合金。 Further preferably, the hard material is a plastic or an alloy. 更进一步优选地,所述合金是不锈钢或镍钛合金。 Still more preferably, the alloy is a stainless steel or nickel titanium alloy. 更进一步优选地,所述工程塑料是聚酰胺或聚酯。 Still more preferably, the plastic is a polyamide or a polyester.

[0059]如上所述,所述螺旋层3由硬质材料制成,其硬度大于导管2的硬度。 [0059] As described above, the helical layer 3 is made of a hard material having a hardness greater than the hardness of the catheter 2. 因此,优选将螺旋层3和导管本体分开制作。 Thus, preferably the catheter body and the coil layer 3 formed separately.

[0060]例如,导管2的制造方法可以包括:制备中空管状基材,所述中空管状基材用作导管本体;制作螺旋状操作丝,所述操作丝的螺旋外径与所述中空管状基材的内径相匹配,所述操作丝的外侧具有凹槽,且所述操作丝在轴向方向上的长度大于所述中空管状基材的长度;制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝能够被嵌入到所述凹槽中;将所述螺旋层丝嵌入到所述凹槽中;将所述螺旋层丝的从所述凹槽暴露的底部涂上粘合剂;将嵌入有所述螺旋层丝的所述操作丝置入所述中空管状基材的内侧;以及使所述螺旋层丝的所述底部与所述中空管状基材的内侧表面粘合牢固。 [0060] For example, a catheter manufacturing method may include: preparing a hollow tubular substrate as the substrate of said hollow tubular catheter body; production operation wire spiral, the spiral outer diameter of the operation wire and said hollow tubular base matches the inner diameter of material, the outer side of the operation wire has a recess, and the operation wire length in the axial direction than the length of the hollow tubular substrate; prepared helical layer filaments, the layer filaments helical size is designed such that the helical layer filaments can be embedded in the groove; helical layer embedding the wire into the recess; exposed from the bottom of the grooves of the helical filaments coated adhesive layer mixture; the operation wire embedded with the spiral filaments into the inner layer of the hollow tubular substrate; and the bottom layer of the coil wire bonding to the inner surface of the hollow tubular substrate firm.

[0061]上述方法通过将所述螺旋层丝粘合到所述中空管状基材来制造本发明的导管。 [0061] By the above method the filament layer is adhered to the helical hollow tubular substrate is manufactured catheter of the invention. 但是本发明不限于该构造。 However, the present invention is not limited to this configuration. 例如,也可以通过将所述螺旋层丝热结合到所述中空管状基材来制造本发明的导管。 For example, it is possible by the wire coil layer thermally bonded to the base of said hollow tubular catheter of the invention is manufactured. 导管2的另一种制造方法可以包括:制备中空管状基材,所述中空管状基材用作导管本体;制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝的螺旋外径小于等于所述中空管状基材的内径;将所述螺旋层丝置入所述中空管状基材的内侧;通过热作用,将所述中空管状基材包覆于所述螺旋层丝上,所述螺旋层丝嵌入所述中空管状基材的深度小于所述螺旋层丝的直径。 Another catheter manufacturing method may include: preparing a hollow tubular substrate as the substrate of said hollow tubular catheter body; prepared helical filament layer, said helical layer is dimensioned such that filaments of said helical wire coil layer an outer diameter less than or equal to the inner diameter of the hollow tubular substrate; wire into the helical inner layer of the hollow tubular substrate; by the action of heat, the hollow tubular substrate is coated on said wire coil layer the depth of the helical wire embedded in the layer of the hollow tubular substrate is less than the diameter of the coil wire layer.

[0062]本发明的导管2能够应用于任何配合导丝进行血管内推送的导管。 [0062] The catheter of the present invention can be applied to any two mating guidewire push intravascular catheter. 以下将结合图 Below in connection with FIG.

3、4示例性说明本发明的导管在快速交换式球囊导管上的应用,应当理解的是,以下说明并不意图将本发明限于快速交换式球囊导管的内管。 3 and 4 illustrate an exemplary application of the catheter of the present invention on a rapid exchange type balloon catheter, it should be understood that the following description is not intended to limit the invention to the inner tube a rapid exchange type balloon catheter.

[0063]在图3所示的实施例中,快速交换式球囊导管所遇最小弯曲半径是9mm(模型),所用导丝为0.014英寸直径或0.178mm半径,根据公式(3)计算得出螺距L应小于3.633mm,取3.6mmο [0063] In the embodiment shown in FIG. 3, a rapid exchange balloon catheter is the minimum bend radius encountered 9mm (model), the guidewire 0.178mm or 0.014 inch diameter radius, is calculated according to equation (3) yields pitch L should be less than 3.633mm, taking 3.6mmο

[0064]如果通过粘合方式来制作该快速交换式球囊导管的内管2,则具体制作过程如下: [0064] If the inner tube to create a rapid exchange type balloon catheter 2 by adhesive means, the specific production process is as follows:

[0065]制备中空管状基材,所述中空管状基材用作导管本体; [0065] Preparation of hollow tubular substrate, the substrate is used as the hollow tubular catheter body;

[0066]制作螺旋状操作丝,所述操作丝的螺旋外径与所述中空管状基材的内径相匹配,所述操作丝的外侧具有凹槽,凹槽螺距L如上所述计算取为3.6mm,且所述操作丝在轴向方向上的长度大于所述中空管状基材的长度,即大于250_或70圈螺纹; [0066] Production operation wire spiral, the spiral outer diameter of the operation wire matches the inner diameter of the hollow tubular substrate, the outer side of the operation wire has a recess, groove pitch 3.6 L calculated as described above is taken as mm, and the operation wire length in the axial direction is larger than the length of the hollow tubular substrate, i.e., greater than or 250_ threaded ring 70;

[0067]制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝能够被嵌入到所述凹槽中; [0067] Production helical filament layer, the dimensions of the helical filament layer is designed so that the helical layer filaments can be embedded in the groove;

[0068]将所述螺旋层丝嵌入到所述凹槽中; [0068] The helical layer filaments embedded in the groove;

[0069]将所述螺旋层丝的从所述凹槽暴露的底部涂上粘合剂; [0069] The adhesive coated from the bottom of the spiral groove exposed layer filaments;

[0070]将嵌入有所述螺旋层丝的所述操作丝置入所述中空管状基材的内侧;以及[0071 ]使所述螺旋层丝的所述底部与所述中空管状基材的内侧表面粘合牢固。 [0070] The operation wire embedded with the spiral filaments into the inner layer of the hollow tubular substrate; and [0071] the bottom layer of the coil wire of the inner hollow tubular base firm bonding surface.

[0072]如果通过热结合方式来制作该快速交换式球囊导管的内管2,则具体制作过程如下: [0072] If the inner tube to create a rapid exchange type balloon catheter 2 by way of thermal bonding, the specific production process is as follows:

[0073]制备中空管状基材,所述中空管状基材用作导管本体; [0073] Preparation of hollow tubular substrate, the substrate is used as the hollow tubular catheter body;

[0074]制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝的螺旋外径小于等于所述中空管状基材的内径,螺旋层丝的螺距L如上所述计算取为3.6mm,且所述螺旋层丝在轴向方向上的长度大于所述中空管状基材的长度,即大于250_或70圈螺纹; [0074] Production helical filament layer, said helical layer filaments dimensioned such that the outer diameter of the helical wire coil layer is less than or equal to the inner diameter of the hollow tubular substrate, the helical pitch of the layer filaments L calculated as described above is taken as 3.6mm, the length of wire and the helical layer in the axial direction greater than the length of the hollow tubular substrate, i.e., greater than or 250_ threaded ring 70;

[0075]将所述螺旋层丝置入所述中空管状基材的内侧; [0075] The helical wire into the inside layer of the hollow tubular substrate;

[0076] 通过热作用,将所述中空管状基材包覆于所述螺旋层丝上,所述螺旋层丝嵌入所述中空管状基材的深度小于所述螺旋层丝的直径。 [0076] By the action of heat, the hollow tubular substrate is coated on said filament helical layer, a depth of the helical layer is inset into the hollow tubular substrate is less than the diameter of the coil wire layer.

[0077]另外,针对如图3(b)、图3(c)、图3(d)所示的三种不同螺旋层剖面形状的具体作法如下: [0077] Further, in FIG. 3 for (B), FIG. 3 (c), (d) shown in FIG. 3 three layers of different specific practices helical cross-sectional shape as follows:

[0078] A.所加螺纹剖面为半球形结构,其剖面半径为0.17mm,采用聚酰胺材料,并与中空管状基材的内侧表面牢固粘合。 [0078] A. added as a hemispherical cross-sectional structure of the thread, which is a cross-sectional radius of 0.17mm, using a polyamide material, and firmly adhered to the inner surface of the hollow tubular substrate.

[0079] B.所加螺纹剖面为等腰三角形,三角形高度取0.17mm,底部宽度为0.34mm,顶点经过打磨,磨去尖角,呈弧形,采用不锈钢材料并与中空管状基材的内侧表面粘合。 [0079] B. added threaded sectional isosceles triangle height take 0.17mm, bottom width of 0.34mm, a vertex polished, rubbed off sharp, curved, stainless steel and the inside of the hollow tubular substrate surface of the adhesive.

[0080] C.所加螺纹剖面为等腰梯形,高度等于0.17mm,长底边为0.34mm,短底边取 [0080] C. was added a sectional isosceles trapezoid thread height equal to 0.17mm, length of 0.34mm base, take shorter base

0.17mm,打磨去短底边的两角,使短底边呈中间高,两侧低的弧形,采用聚酰胺材料制作。 0.17mm, to polish the corners of the smaller base of the intermediate was shorter base high and low sides of the arc, using a polyamide material. 长底边粘合于中空管状基材的内侧表面。 Long base bonded to the inside surface of the hollow tubular substrate.

[0081]在快速交换式球囊导管的制作中应用本发明,在与导丝配合的内管内壁增加本发明所主张结构的螺旋层,在限制保证导管前进方向的同时,大大降低导管与导丝接触面积,减少滑动摩擦阻力,从而减少推进中的摩擦阻力。 While the [0081] application in the production of a rapid exchange balloon catheter according to the present invention, increased helical layer structure of the present invention claimed in the inner wall of the inner tube mating with the guide wire, the catheter is advanced in the direction of the restriction to ensure that, with the guide catheter is greatly reduced wire contact area, to reduce sliding friction resistance, thereby reducing the frictional resistance in advance.

Claims (18)

  1. 1.一种配合导丝进行血管内推送的导管,其中:所述导管的内壁具有螺旋层;所述螺旋层的硬度大于所述导管的硬度; 其特征在于根据以下公式选择所述螺旋层的螺距L: L<=2*sqrt(3r~2+2R*r) 其中r是导丝半径,R是所述导丝的最小弯曲半径,且所述螺旋层的在所述导管的径向方向上的高度取为r。 A guidewire with push intravascular catheter, wherein: the inner wall of the conduit having a helical layer; hardness greater than the hardness of the helical layer of the catheter; wherein said coil layer is selected according to the following formula pitch L: L <= 2 * sqrt (3r ~ 2 + 2R * r) where r is the wire radius, r is the minimum bend radius of the guidewire, and the catheter in the radial direction of the helical layer height is taken as r.
  2. 2.根据权利要求1所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层分布在所述导管的两端之间的任意区域中。 2. With the guide wire according to claim 1 for an intravascular catheter is pushed, characterized in that: said helical layer at an arbitrary region between the profile ends of the conduit.
  3. 3.根据权利要求2所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层分布覆盖所述导管的全部长度。 3. The fitting of the guide wire according to claim 2, Push-intravascular catheters, wherein: said helical layer covers the entire length of the profile of the catheter.
  4. 4.根据权利要求1所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层与所述导丝接触的表面朝向所述导丝突起。 Fitting according to claim 1, wherein said guide wire for intravascular catheter push, characterized in that: the surface layer of the spiral in contact with the guide wire toward the wire guide projection.
  5. 5.根据权利要求1至4中任一项所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层的剖面在所述导管的轴向方向上的宽度朝向所述导丝逐渐变小。 1 according to an intravascular catheter to push the guide wire with any one of 4, claim wherein: said helical layer a cross-sectional width in the axial direction of the catheter toward the guide wire becomes smaller.
  6. 6.根据权利要求5所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层的剖面形状大致为弧形、三角形、梯形或其它多边形。 6. A complex according to claim 5, wherein the guidewire is pushed by an intravascular catheter, comprising: a cross-sectional shape of the coil layer is substantially arcuate, triangular, trapezoidal or other polygonal.
  7. 7.根据权利要求1至4中任一项所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层与所述导丝接触的表面具有用于减少摩擦的涂层。 1 The intravascular catheter to push the guidewire with any one of claims 4, characterized in that wherein: the surface layer in contact with said helical guide wire having a coating for reducing friction.
  8. 8.根据权利要求7所述的配合导丝进行血管内推送的导管,其特征在于:所述涂层包括有机娃。 8. A complex according to claim 7 for the guide wire push an intravascular catheter, wherein: said coating comprises an organic baby.
  9. 9.根据权利要求7所述的配合导丝进行血管内推送的导管,其特征在于:所述涂层包括亲水性有机物或疏水性有机物。 9. A complex according to claim 7 for the guide wire push an intravascular catheter, wherein: said organic coating comprises a hydrophilic or hydrophobic organic material.
  10. 10.根据权利要求9所述的配合导丝进行血管内推送的导管,其特征在于:所述疏水性有机物包括聚四氟乙烯或聚对二甲苯。 10. The mating of the guide wire according to claim 9, for an intravascular catheter push, characterized in that: the hydrophobic organic material comprises a Teflon or parylene.
  11. 11.根据权利要求1至4中任一项所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层的在所述导管的径向方向上的高度小于所述导丝的半径。 11.1 Push-fit to the intravascular catheter guide wire according to any one of claim 4, wherein: a height in the radial direction of the spiral conduit of the layer is less than the guidewire radius.
  12. 12.根据权利要求1至4中任一项所述的配合导丝进行血管内推送的导管,其特征在于:所述螺旋层由硬质材料制成。 12. The guide wire with 1-1 according to any one of the claims 4 push an intravascular catheter, wherein: said helical layer is made of a hard material.
  13. 13.根据权利要求12所述的配合导丝进行血管内推送的导管,其特征在于:所述硬质材料是高分子材料或金属材料。 13. The mating of the guide wire according to claim 12 for intravascular catheter push, wherein: the hard material is a polymer material or metal material.
  14. 14.根据权利要求13所述的配合导丝进行血管内推送的导管,其特征在于:所述硬质材料是工程塑料或合金。 14. A complex according to claim 13 for the guidewire push an intravascular catheter, wherein: the hard material is a plastic or an alloy.
  15. 15.根据权利要求14所述的配合导丝进行血管内推送的导管,其特征在于:所述合金是不锈钢或镍钛合金。 15. The mating of the guide wire according to claim 14 for intravascular catheter push, characterized in that: said alloy is a stainless steel or nickel titanium alloy.
  16. 16.根据权利要求14所述的配合导丝进行血管内推送的导管,其特征在于:所述工程塑料是聚酰胺或聚酯。 16. The mating of the guide wire according to claim 14 for intravascular catheter push, characterized in that: said engineering plastic is a polyamide or a polyester.
  17. 17.—种制造根据权利要求1至16中任一项所述的配合导丝进行血管内推送导管的方法,所述方法包括: 制备中空管状基材,所述中空管状基材用作导管本体; 制作螺旋状操作丝,所述操作丝的螺旋外径与所述中空管状基材的内径相匹配,所述操作丝的外侧具有凹槽,且所述操作丝在轴向方向上的长度大于所述中空管状基材的长度; 制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝能够被嵌入到所述凹槽中; 将所述螺旋层丝嵌入到所述凹槽中; 将所述螺旋层丝的从所述凹槽暴露的底部涂上粘合剂; 将嵌入有所述螺旋层丝的所述操作丝置入所述中空管状基材的内侧;以及使所述螺旋层丝的所述底部与所述中空管状基材的内侧表面粘合牢固。 17.- A method of fabricating a pusher catheter within the blood vessel with the guide wire 16 to any one of the claim, the method comprising: preparing hollow tubular substrate, the substrate is used as the hollow tubular catheter body ; production operation wire spiral, the spiral outer diameter of the operation wire matches the inner diameter of the hollow substrate tube, outside of the operation wire has a recess, and the operation wire length in the axial direction is larger than the length of the hollow tubular substrate; prepared helical layer filaments, the helical layer is dimensioned such that filaments of said helical layer filaments can be embedded in the groove; helical layer embedding the wire into the recess tank; coated with adhesive from the exposed bottom of the groove of the helical layer filaments; embedded with the operation of the helical layer filaments inside of the wire into the hollow tubular substrate; and the bottom layer of the coil wire and the inner surface of the hollow tubular substrate is strongly bonded.
  18. 18.—种制造根据权利要求1至16中任一项所述的配合导丝进行血管内推送的导管的方法,所述方法包括: 制备中空管状基材,所述中空管状基材用作导管本体; 制作螺旋层丝,所述螺旋层丝的尺寸设计为使得所述螺旋层丝的螺旋外径小于等于所述中空管状基材的内径; 将所述螺旋层丝置入所述中空管状基材的内侧; 通过热作用,将所述中空管状基材包覆于所述螺旋层丝上,所述螺旋层丝嵌入所述中空管状基材的深度小于所述螺旋层丝的直径。 18.- A method of fabricating a push for an intravascular catheter with the guide wire 16 to any one of the preceding claims, said method comprising: preparing hollow tubular substrate, the substrate is used as the hollow tubular conduit a body; production helical filament layer, said helical layer filaments dimensioned such that the outer diameter of the helical wire coil layer is less than or equal to the inner diameter of the hollow tubular substrate; wire into the helical layer of the hollow tubular base inside material; by the action of heat, the hollow tubular substrate layer is coated on the filament coil, the depth of the helical layer is inset into the hollow tubular substrate is less than the diameter of the coil wire layer.
CN 201210393570 2012-10-16 2012-10-16 With intravascular guidewire catheter and method for manufacturing the push CN103721337B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201210393570 CN103721337B (en) 2012-10-16 2012-10-16 With intravascular guidewire catheter and method for manufacturing the push

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN 201210393570 CN103721337B (en) 2012-10-16 2012-10-16 With intravascular guidewire catheter and method for manufacturing the push
PCT/CN2013/085274 WO2014059922A1 (en) 2012-10-16 2013-10-16 Catheter coupling with guide wire for intravascular delivery and manufacturing method thereof

Publications (2)

Publication Number Publication Date
CN103721337A true CN103721337A (en) 2014-04-16
CN103721337B true CN103721337B (en) 2017-02-22

Family

ID=50445794

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201210393570 CN103721337B (en) 2012-10-16 2012-10-16 With intravascular guidewire catheter and method for manufacturing the push

Country Status (2)

Country Link
CN (1) CN103721337B (en)
WO (1) WO2014059922A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105749405A (en) * 2014-12-19 2016-07-13 谷村哲明 Catheter system comprising oviduct lens and combination method of system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228110B1 (en) * 1998-06-26 2001-05-08 Scimed Life Systems, Inc. Stent delivery system
US6730105B2 (en) * 1988-07-29 2004-05-04 Samuel Shiber Clover leaf shaped tubular medical device
US6849062B2 (en) * 2002-08-23 2005-02-01 Medtronic Vascular, Inc. Catheter having a low-friction guidewire lumen and method of manufacture
CN2824973Y (en) * 2005-04-22 2006-10-11 董永华 Medical guide wire

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840623A (en) * 1988-02-01 1989-06-20 Fbk International Corporation Medical catheter with splined internal wall
FR2657945B3 (en) * 1990-02-07 1992-01-17 Lee Jong Ho Multilayer pipe comprising helicouidales protuberances fluid guide on its inner surface.
US5334169A (en) * 1992-05-11 1994-08-02 American Interventional Technologies, Inc. Reinforced catheter with thin monolithic walls
JP3394327B2 (en) * 1994-07-11 2003-04-07 テルモ株式会社 Inner surface processing method of the tube

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730105B2 (en) * 1988-07-29 2004-05-04 Samuel Shiber Clover leaf shaped tubular medical device
US6228110B1 (en) * 1998-06-26 2001-05-08 Scimed Life Systems, Inc. Stent delivery system
US6849062B2 (en) * 2002-08-23 2005-02-01 Medtronic Vascular, Inc. Catheter having a low-friction guidewire lumen and method of manufacture
CN2824973Y (en) * 2005-04-22 2006-10-11 董永华 Medical guide wire

Also Published As

Publication number Publication date Type
WO2014059922A1 (en) 2014-04-24 application
CN103721337A (en) 2014-04-16 application

Similar Documents

Publication Publication Date Title
US6652472B2 (en) Guidewire with smoothly tapered segment
US5368049A (en) Superelastic formable guidewire with malleable cladding
US6620114B2 (en) Guidewire having a marker segment for length assessment
US6106485A (en) Guidewire with shaped intermediate portion
US6736839B2 (en) Medical device delivery system
US7371248B2 (en) Steerable distal protection guidewire and methods of use
US6080140A (en) Integral cerebro-vascular access system
US7001369B2 (en) Medical device
US20080147001A1 (en) Rapid-exchange balloon catheter shaft and method
US6254550B1 (en) Preformed wire guide
US20080255654A1 (en) System for delivering a stent
US20060264904A1 (en) Medical device
US5603704A (en) Multi-purpose curve
US5333620A (en) High performance plastic coated medical guidewire
US5924998A (en) Guide wire with hydrophilically coated tip
US5916178A (en) Steerable high support guidewire with thin wall nitinol tube
US20120016344A1 (en) Aspiration catheter
US6132389A (en) Proximally tapered guidewire tip coil
US20060173382A1 (en) Guidewire with superelastic core
US7850623B2 (en) Elongate medical device with continuous reinforcement member
US20060074477A1 (en) Self-expanding stent delivery system
US20040230178A1 (en) Cutting balloon catheter with improved pushability
US6251086B1 (en) Guide wire with hydrophilically coated tip
EP0823261A2 (en) Guidewire having a distal tip that can change its shape within a vessel
US20040167440A1 (en) Multiple diameter guidewire

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
C14 Grant of patent or utility model