CN103705229A - Method and system for testing ECAP (equal-channel angular pressing) signals in cochlea - Google Patents
Method and system for testing ECAP (equal-channel angular pressing) signals in cochlea Download PDFInfo
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Abstract
The invention provides a method and a system for testing ECAP (equal-channel angular pressing) signals in a cochlea. The system comprises an electrode array, an internal testing signal receiving and controlling device, a first processor and a second processor, wherein the electrode array and the internal testing signal receiving and controlling device are arranged in the body of a user; the first processor and the second processor are positioned out of the body of the user; the first processor provides coding electrical stimulation signals for the internal testing signal receiving and controlling device, and is also used for providing stimulation current for a certain electrode or several electrodes in the electrode array; measurement operation is carried out by setting the first processor or the measuring electrodes; the internal testing signal receiving and controlling device stimulates the electrodes in the electrode array through a switch array, and electrode impedance, electrode potential and ECAP signal measurement are carried out; and useful compound control action potential signals are recovered and extracted through the second processor by using a polarity alternating method. The animal testing electrodes are easy to implant and can effectively stimulate auditory nerves; and by using a DSP (digital signal processor) chip and a singlechip MPU (microprocessor unit), the external processors and the internal implanted system are low in cost and effective.
Description
Technical field
The present invention relates to the field of signal and information processing, be particularly applied to test ECAP small-signal in cochlea of guinea pigs, and the invention provides a kind of for measuring the method and system of ECAP signal in cochlea.
Background technology
Cochlear implant (cochlear implant) is uniquely can help severe deafness patient directly to stimulate remaining auditory nerve with the system of recovered part audition by the signal of telecommunication.In cochlear implant implant system, by electrode, to acoustic nerve, apply specific galvanism, measuring acoustic nerve is that electricity brings out compound action potential (Electrically Evoked Compound Action potential-ECAP) to the reaction potential of this stimulation, can detect auditory nerve function; By measuring ECAP signal, in reception/stimulator implantation overall process, monitor auditory nerve response; After artificial cochlea system has been implanted, in implantation person's debug process, measure ECAP signal, can definite threshold T value (T-levels), electronic cochlea implant persons can be heard the lightest speech sound and ambient sound; Can determine comfort level C value (C-levels), the galvanism that the maximum sound that implantation person at any time can comfortablely stand produces; By measuring ECAP signal, can determine M value (M-levels), i.e. the endurable maximal stimulus intensity that can not cause the obvious uncomfortable sensations such as pain of implantation person simultaneously.Therefore by test cochlea ECAP signal, the electrode can be to Operation cochlear implant time carries out effective monitoring; In debug process, make each implantation person obtain best auditory effect.Because cochlea of guinea pigs has similar structure with mankind's cochlea, while being usually used in studying electricity irritation cochlea, the experiment of auditory nerve response.The ECAP signal of cochlea of guinea pigs has certain characteristic, can design corresponding measurement-recording system according to the feature of signal.When must reaching certain threshold value, the intensity of stimulating current just can excite nerves reaction electric potential signal, and the amplitude of the ECAP causing only tens of between hundreds of μ V, owing to all there is certain electric capacity in measuring system and guinea pig tissues, after stimulating current end-of-pulsing, will there is a period of time (amplitude is by exponential law decay) in the current potential directly being produced by this electric current, so the ECAP signal that will measure is to coexist with the electric potential signal directly being produced by stimulating current, and the amplitude maximum of stimulating current can reach 2～3 orders of magnitude of ECAP signal, therefore must there is a kind of strategy, from very strong stimulus signal background, extract relatively faint ECAP signal, catching this small-signal needs measuring system to reduce the background noise of system, in order to avoid ECAP signal is submerged in noise, when stimulating current amplitude reaches threshold value, to bring out auditory nervous system reacts and produces ECAP signal, if but while being less than certain value the interval time of subsequent stimuli pulse, even if stimulus intensity has surpassed threshold value, nervous system will can not reacted yet, and follow-up boost pulse is inoperative, in order to obtain the ECAP signal of cochlea of guinea pigs, when continuous impulse stimulates measurement, the cycle of its boost pulse must be greater than the refractory stage of ECAP, when boost pulse reaches threshold value, by the signal pulse that brings out auditory system and make a response and produce response, but response impulse has certain time delay to boost pulse, be also the operating lag of ECAP signal, so the total duration of boost pulse can not be greater than the operating lag of ECAP signal.According to the present invention of the characteristics design of ECAP, can effectively capture the ECAP small-signal that amplitude is μ V level, for research auditory nerve characteristic provides strong instrument.According to these features of ECAP signal,
At present mainly contain in the world San Jia enterprise and produced the cochlear implant system with reverse telemetry function, be i.e. the Cochlear company of Australia, the AdvancedBionic company of Austrian MED-EL company and the U.S..To Cavia porcellus ECAP signal research more be Charls A.Miller and the colleague thereof of Iowa State University.The ripe cochlear implant product of the current more employing of CharlsA.Miller laboratory carries out the research of Cavia porcellus ECAP, but external existing product involves great expense and output of products is strictly controlled, therefore the system that the present invention is intended to design a set of low cost, effectively tests cochlea of guinea pigs ECAP signal, the electricity producing while being convenient to experimentation electricity irritation cochlea of guinea pigs auditory nerve brings out compound action potential characteristic, and while being subject to electricity irritation for further studying severe deafness patient residual hearing nerve, response characteristic is established experiment basis.
Summary of the invention
The object of the invention is to, during for surveying record electricity irritation cochlea of guinea pigs, auditory nerve brings out compound action potential the present invention and proposes a kind of new system that is applied to test organisms nerve signal, can test record analyzes the bioelectrical signals of μ V level.
To achieve these goals, the invention provides a kind ofly for testing the system of ECAP signal in cochlea, described system comprises:
The electrod-array and the body build-in test signal that are positioned at body receive and controller, and are positioned at external first processor and the second processor;
Described first processor, be used to described body build-in test signal reception and controller that coding electrical stimulation signal is provided, this processor is also used to certain or certain the several electrodes in described electrod-array that stimulating current is provided simultaneously, by setting this or these measurement electrode, starts measuring operation;
Described body build-in test signal receives and controller, for the electrode that stimulates described electrod-array to comprise by switch arrays, thereby complete electrode impedance, electrode potential and the ECAP signal measurement of cochlea of guinea pigs, and the signal measuring is transferred to external first processor;
Described the second processor, for adopting the in-vivo measurement signal that polarity alternating method obtains from first processor recover and extract useful compound action potential signal, is also the measured ECAP signal arriving.
In technique scheme, the mode that described body build-in test signal receives and controller is modulated the measurement data of the electrod-array of its reception with ASK is sent to described first processor.
In technique scheme, described first processor is set up communication by RS-232 serial ports with the second processor.
In technique scheme, after the data encoding that described body build-in test signal receives and controller is also measured electrod-array, by radio-frequency communication passage, return to described first processor.
In technique scheme, the described first processor also mode by radio-frequency transmissions carrier wave receives and controller provides energy for described body build-in test signal.
Based on said system the present invention, also provide a kind of for testing the method for ECAP signal in cochlea, described method comprises:
Step 101) produce stimulating current parameter, and choose some or certain several electrode in the electrod-array in cochlea of guinea pigs as stimulating electrode;
Step 102) the stimulating current parameter role of generation is carried out to the measurement of electrode impedance, electrode potential or ECAP signal in the stimulating electrode of choosing;
Step 103) after measurement result coding stimulating electrode being obtained, return to device outside;
Wherein, described electrod-array comprises the reference electrode of 2-8 ring-type stimulating electrode and 2 lamellars.
Optimize described method step 101) also comprise after producing stimulating current parameter:
For controlling the step of device outside duty, this step completes the first processor that parameters sends and is set to waiting state, waits for the measurement result receiving from returning in body.
Further optimize, describedly for testing the method for the ECAP signal of cochlea of guinea pigs, also comprise:
Be used to implant that the step of energy is provided, this step is specially described device outside and launches constant amplitude RF carrier wave by radio-frequency communication, to implant, provides energy.Described method also comprises stimulating electrode and is set to stimulate main electrode and stimulates auxiliary electrode, and gains and time delay for described electrode arranges.
Above-mentioned stimulating current parameter comprises: the speed that stimulating current amplitude, boost pulse width and stimulation repeat; Measure portion need to arrange to be measured main electrode and measures auxiliary electrode number.
In a word for achieving the above object, the present invention proposes and comprise the extracorporeal treatment of electricity irritation device can be provided, reception/the stimulator of decodable code coding, can pass through the electrod-array of Operation cochlea of guinea pigs, surveyed ECAP signal is carried out to the software system of analyzing and processing.
The invention has the advantages that and made the zoopery electrode that is easy to implant, can effective stimulus, adopt general commercial DSP chip to realize the Main Processor Unit of extracorporeal treatment device, reduce cost and the construction cycle of system development, body build-in test signal receives and controller is selected commercial chip microcontroller controlled processing unit and select the design of variable connector effectively to control stimulating electrode, adopt the mode that records ECAP signal in snail, reduce environmental disturbances, make surveyed ECAP signal more accurate.
Accompanying drawing explanation
The systemic-function theory diagram of Fig. 1 embodiment of the present invention;
The electrode array configurations schematic diagram of Fig. 2 embodiment of the present invention;
The extracorporeal treatment device composition frame chart that Fig. 3 embodiment of the present invention provides;
Reception/stimulator composition frame chart that Fig. 4 embodiment of the present invention provides;
The flow chart of the measurement electrode impedance that Fig. 5 embodiment of the present invention provides, electrode potential and ECAP signal.
Accompanying drawing sign
1, the second processor 2, first processor
3, body build-in test signal receives and controller
4, electrod-array 5, electrode plates 6, ADC
7, power supply 8, dsp processor 9, coding
10, modulation 11, transmitting coil 12, demodulation
13, decoding 14, RF crystal oscillator 15, clock recovery
16, data recovery 17, data decode 18, single-chip microcomputer
19, current source 20, variable connector 21, electrod-array
22, amplifying signal 23, data storage 24, transfer of data
The specific embodiment
Below in conjunction with accompanying drawing, technical scheme of the present invention is elaborated.
As shown in Figure 1, the step of system works is as follows for the systemic-function theory diagram that the present invention proposes:
(1) by operation, the electrod-array of system is implanted to cochlea of guinea pigs.The electrod-array of native system design comprises the reference electrode of 3 ring-type stimulating electrodes and 2 lamellars; Electrode shape as shown in Figure 2.What moderate stimulation electrode of the present invention adopted is 3 ring electrode arrays, is loaded on the colloidal silica that tip diameter is 0.5mm, and the centre distance between pole piece is 0.75mm, and the width of pole piece is 0.3mm, and the distance between adjacent pole piece is 0.45mm.Reference electrode adopts oval-shaped pole piece, and pole piece diameter is 0.4mm, is loaded on the colloidal silica that diameter is 0.5mm.Native system design adopts the mode recording in snail to record cochlea of guinea pigs and is subject to after electricity irritation, auditory nerve brings out compound action potential, reduce brain stem record and needed the surveying record device designing, the ECAP signal that acquisition amplitude is larger, has reduced the interference that ECAP signal is subject to environment noise and background noise of surveying;
(2) the second above-mentioned processor specifically can adopt PC, and described PC is connected and realizes two-way communication with external processor (being the first processor of describing in technique scheme) by rs-232 standard interface.PC is controlled and is started total system work.Specific works flow process is to set up PC to be connected with the communication of extracorporeal treatment device, PC provides measures the setting of controlling, completing the setting of RS-232 messaging parameter and communication shakes hands, control data are sent to extracorporeal treatment device by communication interface, now PC, in waiting state, waits for that extracorporeal treatment device can send data;
(3) extracorporeal treatment device receives the measurement control data that PC sends, and processes accordingly and operate its functional schematic block diagram as shown in Figure 3.The main processor unit of extracorporeal treatment device is general commercial dsp chip, extracorporeal treatment device by comprise between exciting current amplitude, pulse width, electrode number, measuring amplifier gain, each pulse and and measure between the data of sequential in the mode of Manchester's code, directly send to reception/stimulator; Wherein include repeatedly to measure repetition rate and measure after the control data such as average time are explained execution by extracorporeal treatment device and complete the control to reception/stimulator; Extracorporeal treatment device sends control data to reception/stimulator, in waiting state, wait for and receive the coded data that the test of returning from reception/stimulator obtains including ECAP signal, now extracorporeal treatment device is launched constant-amplitude carrier by radio-frequency communication, to implant, provide energy, do not send any data.Now RF-Link passage transmitting constant-amplitude carrier, provides energy to implant, does not send any data;
(4) reception/stimulator under processor is controlled in vitro, carries out concrete measuring operation.The theory diagram of reception/stimulator as shown in Figure 4.First reception/stimulator completion system initializes and arranges; According to receive controlling data, carry out setting operation, the DAC by reception/stimulator system arranges stimulating current amplitude, system design stimulating current amplitude range 1-255cu; According to the DAC of the selected 10-bit of system, stimulating current maximum can arrive 1245 μ A, and this design can be studied different stimulating current amplitudes to cochlea of guinea pigs ECAP signal amplitude and preclinical impact; By set timer boost pulse width, the scope of the pulse width that can arrange is 10-1030 μ s; By variable connector, select stimulating electrode and measurement electrode, by variable connector, measuring amplifier is set and gains, for the ECAP signal of surveyed μ V level is effectively amplified, system adopts third stage amplifier design, the scope that the arranges 1-4000 of system gain; Produce exciting current and send to the i-coch electrod-array of implantation, the production process of stimulating current is as follows, according to control information, opens exciting current switch, according to controlling data automatic-control pulse width, automatically completing electric current commutation and automatically stop driving pulse;
(5) complete after stimulation applications, system enters measurement procedure.According to control information, start process of measurement, open measuring-signal switch, start ADC, read and storage of measurement data, and finish voluntarily process of measurement after arriving measurement duration.The measurement of system comprises that it is ECAP signal measurement that the electricity of the measurement of the measurement of electrode impedance in electrod-array, electrode potential, auditory nerve is brought out to compound action potential;
(6) after reading an adc data, wait for once adc data during complete, the coding that measurement result is stipulated on demand, then by coded data the RF-Link passage by reception/stimulator return extracorporeal treatment device (system acquisition to the mode that must modulate by ASK through certain transmission channel of data via receiving coil, send it back extracorporeal treatment device, the transmission coil of extracorporeal treatment device unit and the percutaneous in system of receiving coil are herein attached together, the mode communication by RF (being also radio frequency)); After the corresponding operation that receives control data defined completes, reception/stimulator, in waiting state, is waited for the arrival of next measurement control data;
(7) extracorporeal treatment device receive reception/stimulator foldback include ECAP amplitude and incubation period information data flow, it is carried out to decode operation, and decoded data is turned back to PC.After this extracorporeal treatment device sends in waiting for PC the state that next group is controlled data;
(8) after PC receives the measurement data that extracorporeal treatment device returns, process accordingly.
Date processing content comprise:
1) according to measure the item content and method, data are calculated accordingly, system one-shot measurement sends one group of diphasic pulse code that polarity is staggered, and the data of surveying are added and subtracted the equal computing of peace mutually can obtain ECAP oscillogram, can determine amplitude and the incubation period of ECAP signal according to oscillogram;
2) reject obviously abnormal data, the form of the artefact journey exponential damping of the data of surveying should be rejected if there is saltus step in surveyed data data, assurance correctness during the ECAP signal amplitude of surveying calculating;
3) demonstration of measurement data result, adopts for impedance measurement and potential measurement the form that comprises that numerical value shows and waveform shows, the form that adopts waveform to show to surveyed ECAP signal;
4) metrical information and result are filed with * .txt and * .cap form.
5) interpretation of result, the ECAP signal that system can be preserved imports to the artificial N1/P1 of extraction point in EXCEL document, or manually determines avaivable electrode etc.;
(9) system has completed once complete stimulating course, waits for next time and measuring.
Embodiment
The present invention proposes a kind of test cochlea of guinea pigs and is subject to after electricity irritation, auditory nerve electricity brings out the system of compound action potential (ECAP), can study under different stimulating current amplitudes, boost pulse width, amplifier gain, different stimulation mode, auditory nerve EER characteristic, while being subject to electricity irritation for further studying mankind's cochlea, acoustic nerve electricity brings out compound action potential and establishes experiment basis.Each step of the present invention is specifically implemented as follows, shown in figure 5: (1) is implanted to electrod-array in the cochlea of guinea pigs that middle ear are intact.In implantation process, first by Cavia porcellus anesthesia, lumbar injection 20% carbamic acid alcoholic solution (6ml/kg).After Animal Anesthesia, along the trailing edge incision skin of auricle root, chorista, picks clean muscle, exposes the mastoid bone at external auditory canal opening rear.With ossiculum, be drilled in and in mastoid process, bore an aperture, and be carefully expanded into the bone hole that diameter is 3 ~ 4mm.In the deep that is equivalent to external auditory meatus inner side, the rear upper part of the visible basal turn that pocket rises from top to bottom and the end, turn the oeil de boeuf of top.Oeil de boeuf mouth is top outward, and its anteroposterior diameter is about 0.8mm.By leading electrode deep insertion forward through bone hole, electrode tip is contacted with round window membrane.
(2) electrod-array is implanted to after cochlea, by starting the main interface of PC start-up routine, selects " entering reverse measurement pattern ".Model communication connection,
1) set up the communication connection between PC and extracorporeal treatment device, complete the setting of RS-232 messaging parameter, complete communication handshake;
2) after successfully having set up communicating by letter between PC and extracorporeal treatment device, the communication connection status of inquiry extracorporeal treatment device and implant;
(3) complete after communication connection State selective measurements project.First carry out electrode impedance measurement.The feature of this measurement is exciting electrode is identical electrode with measurement electrode, applies exciting current and measurement occurs in synchronization, and measured signal voltage amplitude is large (V magnitude).Select electrode mode, adopt one pole to measure, boost pulse diphasic pulse code current polarity selects negative pole front, select the amplitude of stimulating current, optional scope 1-255cu, measures repetitive stimulation speed optional 1,2,5,10,20,30Hz, measures repetition rate for each measuring process definition, obtains the frequency of one group of initial data, in the measuring process of electrode impedance, measuring repetition rate is exactly the frequency that obtains measurement result data.The measurement result of electrode impedance shows with the form of numerical value and figure.
(4) select to carry out the measurement of electrode potential.The feature of this measurement is exciting electrode is different electrode from measurement electrode, but applies exciting current and measurement occurs in synchronization, measured signal voltage amplitude medium (tens～hundreds of mV magnitude).The parameter that electrode potential measure to need arranges comprises stimulating electrode pattern, is divided into bipolar, unipolar stimulation, can select the polarity of stimulating current, anodal at front or negative pole front; Excitation parameters need to be set, excitation main electrode number, under monopolar mode, optional 1,2,3, excitation negative electrode number selects 0 under monopolar mode, and the amplitude range of choice 1-255cu of stimulating current stimulates repetition rate optional 1,2,5,10,20,30Hz; During measurement electrode current potential, because stimulating electrode and measurement electrode adopt different electrodes, therefore need setting measurement electrode, system that " State selective measurements electrode automatically " function is provided, automatically select except exciting electrode all electrodes or therefrom manually selection need some electrodes of scanning survey.Automatic Program generates selecting the control data of electrode measurement, realizes the scanning survey in turn to selected electrode EF.
(5) carry out the measurement of Cavia porcellus ECAP signal.First measurement parameter is set.During ECAP signal measurement, stimulating motivation needs to arrange stimulates main electrode and stimulates auxiliary electrode number, the speed that stimulating current amplitude and boost pulse width and stimulation repeat; Measure portion need to arrange to be measured main electrode and measures auxiliary electrode number, gain and time delay.The amplitude range of choice 1-255cu of stimulating current, stimulates repetition rate optional 1,2,5,10,20,30Hz; It is 10-1030 μ s that the width of boost pulse arranges scope, and under monopolar mode, measuring main electrode number optional scope is 1-15, but be not equal to, stimulates main electrode number.Measuring the optional scope of auxiliary electrode is 0-15, but be not equal to, measures main electrode number.The scope that amplifier gain can arrange is 1/5/10/20/50/100/200/400/1000/4000 totally 10 grades of selections.Transfer delay set of time scope is 0-1030 μ s.After parameter setting completes, enter into measuring phases.After measurement finishes, measurement result is calculated and shown.System adopts polarity alternating method to calculate the result that ECAP measures.The chiastic computational process of polarity is as follows:
For given measurement average time M, each takes turns the staggered ECAP measurement of complete polarity will carry out measuring and producing for M time M data set.
The data set that the staggered ECAP measurement of complete polarity each time produces comprises 2 data sequence, by measurement and loopback order, is labeled as successively A (1)～A (40) and B (1)～B (40).
First organizing interior data calculates: E (i)=(A (i)+B (i))/2, wherein i=1～40
And then average computation between organizing: E (i) meansigma methods=(E (i, 1)+E (i, 2)+... + E (i, M))/M
Finally each E (i) meansigma methods is scaled to actual voltage value.
ECAP measurement result shows and to comprise electrode number, measurement data, the actual voltage value that shows ECAP, if data transfinite, to warn color demonstration.The oscillogram of drawing ECAP, X-axis is the time, the ECAP current potential that Y-axis is this electrode measurement.Waveform corresponding to the data that transfinite shows with warning color.System adopts polarity alternating method to be easier to realize, and amount of calculation relative scale method of elimination and forward direction screen method are less.
Complete ECAP measuring process one time, change parameter and measure next time.
(6) the data impedance measuring and potential data are according to * .imp and * .txt, and ECAP signal is preserved with * .cap and * .txt form, so that pc machine is done further checking, process.
In a word, the present invention relates to a kind ofly while being applied to electricity irritation cochlea of guinea pigs, the system of the ECAP signal producing in cochlea of guinea pigs is analyzed in test record.System comprises: multi-electrode stimulating electrode array, reception/stimulator, extracorporeal treatment device, debugging recording system.The present invention adopts the zoopery stimulating electrode of making by Operation cochlea of guinea pigs, stimulated in vitro device of the present invention is implemented electricity irritation to cochlea of guinea pigs, by the mode of radio-frequency transmissions, stimulus information after coding is transferred to the reception/stimulator in the present invention, reception/stimulator is measured acoustic nerve in snail to the compound action potential of this electric stimulus inducing (Electrically Evoked Compound Action potential-ECAP) and eliminates artefact and processing and amplifying by controlling stimulating electrode, measurement result is returned to extracorporeal treatment device by the mode of radio communication, extracorporeal treatment device is shown to PC the transfer of data being recorded to analyze by RS232 interface body.
The specific implementation means that such scheme adopts are as follows:
1. designed and produced the electrod-array of convenience implantation cochlea of guinea pigs,
In embodiment, adopt 3 stimulating electrodes and two reference electrodes, adopt the mode of laser spot welding that very little platinum filament and the very little platinized platinum of area of diameter welded together (having solved diameter is the Welding Problems of platinumiridio silk and the direct platinized platinum for 0.3mm of 30 μ m), and at diameter, be on 0.4mm colloidal silica by 3 stimulating electrode array encapsulations, centre distance between adjacent stimulating electrode is only 0.45mm, more effectively stimulation in guinea pigs basilar membrane; Specifically as shown in Figure 2.2, the extracorporeal treatment device that adopts general dsp chip to realize;
The Main Processor Unit of extracorporeal treatment device (that is, described first processor) adopts the TMS320VC5502 of TI company,
When forward data transmission, DSP is responsible for coding and the transmission of data, data after the coding that DSP comprises stimulating electrode, stimulating current selection by McBSP to radio frequency chip transmission, and the coded format of data is as follows:
When reverse link communication, by detecting the DOUT of radio frequency chip, the positive pulse of exporting the interval of identifying adjacent pulse forward position complete data decode to DSP, receive and the later data of decoding by UART and the level shifting circuit of DSP, by RS-232 interface, be sent to the second processor and be for further processing.During oppositely transmitting data, DSP stops exporting any data to radio frequency chip, makes the constant-amplitude carrier of radio frequency chip maintenance stable output, to oppositely transmit data by reception/stimulator by load-modulate;
3, described body build-in test signal receives and controller employing general single chip (MPU) realization.
Described body build-in test signal receives and radio frequency reception, demodulation, the decoding of controller are realized by hardware circuit, and as shown in Figure 4, output stream is directly delivered to the RX end of the UART of MPU, receives data input pin.Body build-in test signal receives and controller is operated in respectively 2 programs, i.e. forward working procedure and orientation measurement program.Forward working procedure realizes acous stimulation according to controlling data.Word is set now extracorporeal treatment device transmission groundwork parameter and particular job parameter arranges 2 control words of word, and this 2 control words are identified and processed to implant system.Groundwork parameter arranges word and has stipulated stimulating current stepping benchmark, the stimulating electrode number that participates in this circulation and boost pulse width.It is 16 that groundwork parameter arranges word, is divided into two continuous sending and receivings of byte.Groundwork parameter arranges word and arranges as follows:
Body build-in test signal receives and controller is receiving after groundwork parameter arranges word, thinks that N subsequent commands word is thereafter particular job parameter word is set.Particular job parameter arrange word corresponding be a stimulation applications of each electrode, it has stipulated that a concrete stimulation action occurs on that electrode and the current intensity of using changes along with electrode number in each stimulation cycle.Particular job parameter arranges word:
The reverse process of measurement of the reception of body build-in test signal and controller is for realizing the measurement (ECAP) of electrode impedance, electrode potential and electric stimulus inducing acoustic nerve reaction potential.Each four control words of correspondence of measuring, send to reception/stimulator by extracorporeal treatment device in order successively, and reception/stimulator is carried out one-shot measurement after receiving, understanding, and then one group of result data of this measurement is oppositely sent to external first processor.Oppositely measure control word and comprise three 16 continuous words, control word 1 control impuls phase order, boost pulse width, measurement electrode are selected and measuring amplifier gain; Control word 2 control survey sample rates, measurement window length and measure the zero hour; Stimulating electrode and stimulating current intensity controlled in word 3 processed.After reverse process of measurement enters, among Infinite Cyclic, often receive one group of (3) control command word, just carry out one-shot measurement and operate and send measurement result, until system closedown or again reset.
It should be noted last that, above embodiment is only unrestricted in order to technical scheme of the present invention to be described.Although the present invention is had been described in detail with reference to embodiment, those of ordinary skill in the art is to be understood that, technical scheme of the present invention is modified or is equal to replacement, do not depart from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (10)
1. for testing a system for ECAP signal in cochlea, described system comprises:
The electrod-array and the body build-in test signal that are positioned at body receive and controller, and are positioned at external first processor and the second processor;
Described first processor, be used to described body build-in test signal reception and controller that coding electrical stimulation signal is provided, this processor is also used to certain or certain the several electrodes in described electrod-array that stimulating current is provided simultaneously, by setting this or these electrode, starts measuring operation;
Described body build-in test signal receives and controller, for the electrode that stimulates described electrod-array to comprise by switch arrays, thereby complete electrode impedance, electrode potential and the ECAP signal measurement of cochlea of guinea pigs, and the signal measuring is transferred to the first processor of guinea pig in vitro;
Described the second processor, for adopting the in-vivo measurement signal that polarity alternating method obtains from first processor recover and extract compound action potential signal, is also the measured ECAP signal arriving.
2. according to claim 1ly for testing the system of ECAP signal in cochlea, it is characterized in that, described body build-in test signal receives and controller is sent to described first processor by the measurement data of the electrod-array of its reception in the mode of ASK modulation.
3. according to claim 1ly for testing the system of ECAP signal in cochlea, it is characterized in that, described first processor is set up communication by RS-232 serial ports with the second processor.
4. according to claim 1ly for testing the system of ECAP signal in cochlea, it is characterized in that, after the data encoding that described body build-in test signal receives and controller also will electrod-array be measured, by radio-frequency communication passage, return to described first processor.
5. according to claim 4ly for testing the system of ECAP signal in cochlea, it is characterized in that, the described first processor also mode by radio-frequency transmissions carrier wave receives and controller provides energy for described body build-in test signal;
Described electrod-array comprises the reference electrode of 2-8 ring-type stimulating electrode and 2 lamellars.
6. for testing a method for i-coch ECAP signal, described method comprises:
Step 101) produce stimulating current parameter, and choose some or certain several electrode in i-coch electrod-array as stimulating electrode;
Step 102) the stimulating current parameter role of generation is carried out to the measurement of electrode impedance, electrode potential or ECAP signal in the stimulating electrode of choosing;
Step 103) after measurement result coding stimulating electrode being obtained, return to device outside;
Wherein, described electrod-array comprises the reference electrode of 2-8 ring-type stimulating electrode and 2 lamellars.
7. according to claim 6ly for testing the method for ECAP signal in cochlea, it is characterized in that described step 101) in also comprise after producing stimulating current parameter:
For controlling the step of device outside duty, this step completes the first processor that parameters sends and is set to waiting state, waits for the measurement result receiving from returning in body.
8. according to claim 7ly for testing the method for ECAP signal in cochlea, it is characterized in that, described method also comprises:
Be used to implant that the step of energy is provided, this step is specially described device outside and launches constant amplitude RF carrier wave by radio-frequency communication, to implant, provides energy.
According to described in 6 for testing the method for ECAP signal in cochlea, it is characterized in that, described method also comprises stimulating electrode and is set to stimulate main electrode and stimulates auxiliary electrode, and gain and time delay is set for described electrode.
According to described in 6 for testing the method for ECAP signal in cochlea, it is characterized in that, described stimulating current parameter comprises: stimulating current amplitude, boost pulse width and stimulate the speed repeating; Measure portion need to arrange to be measured main electrode and measures auxiliary electrode number.
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| US11733776B2 (en) | 2021-07-29 | 2023-08-22 | Moshe OFER | Methods and systems for non-sensory information rendering and injection |
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| CN104622457A (en) * | 2015-02-15 | 2015-05-20 | 山东大学 | Multichannel synchronous cochlea auditory nerve action potential measuring system and multichannel synchronous cochlea auditory nerve action potential measuring method |
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