CN103656297A - Chinese drug agentia for treating tympanitis and preparation method of Chinese drug agentia - Google Patents
Chinese drug agentia for treating tympanitis and preparation method of Chinese drug agentia Download PDFInfo
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- CN103656297A CN103656297A CN201310684316.2A CN201310684316A CN103656297A CN 103656297 A CN103656297 A CN 103656297A CN 201310684316 A CN201310684316 A CN 201310684316A CN 103656297 A CN103656297 A CN 103656297A
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- 239000003390 Chinese drug Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 208000025301 tympanitis Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract description 34
- 241000426256 Cyanotis Species 0.000 claims abstract description 13
- 241000594394 Hedyotis Species 0.000 claims abstract description 13
- 241000931705 Cicada Species 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 6
- 206010033078 Otitis media Diseases 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 241000245240 Lonicera Species 0.000 claims description 7
- 235000009815 Momordica Nutrition 0.000 claims description 7
- 241000218984 Momordica Species 0.000 claims description 7
- 235000008216 herbs Nutrition 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 208000022760 infectious otitis media Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 229940126701 oral medication Drugs 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000067538 Abutilon indicum Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241001499359 Francolinus pintadeanus Species 0.000 abstract 1
- 241001547426 Malvastrum Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 210000000078 claw Anatomy 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 229940088679 drug related substance Drugs 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 3
- 210000000959 ear middle Anatomy 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010014020 Ear pain Diseases 0.000 description 2
- 206010014025 Ear swelling Diseases 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000007176 earache Diseases 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 210000002388 eustachian tube Anatomy 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000001595 mastoid Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 206010061819 Disease recurrence Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013196 antibiotherapy Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese drug agentia for treating tympanitis and a preparation method of the Chinese drug agentia. The Chinese drug agentia comprises the following drug substances in parts by weight: 5-8 parts of roots of Indian abutilon, 9-13 parts of common cyanotis roots, 5-8 parts of coromadel coast falsemallow herb, 3-8 parts of auricled hedyotis herb, 10-20 parts of honeysuckle, 6-9 parts of prepared rehmannia roots, 12-20 parts of fructus momordicae, 6-12 parts of borneol, 5-8 parts of finless eel blood, 10-14 parts of cicada ecdysis and 5-8 parts of Chinese francolin claw. Compared with the prior art, the Chinese drug agentia for treating tympanitis and the preparation method of the Chinese drug agentia have the following advantages: on one hand, the efficacy is significant, and the patient resistance is enhanced; the price is low, the Chinese drug agentia has no toxic or side effects, and the preparation method is simple and convenient and suitable for clinical application; on the other hand, as an oral drug, the Chinese drug agentia is more convenient to use than external medicine, and is not easy to relapse.
Description
Technical field
The present invention relates to Chinese medicine preparation and preparation method thereof, relate in particular to a kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof.
Background technology
Otitis media is a kind of disease of harm humans health, and otitis media is the inflammatory lesion of involving all or part of structure of middle ear (comprising pharyngotympanic tube, tympanum, tympanic antrum and mastoid air cell); This inflammation, as treatment not in time, also easily causes other concurrent inflammation, to patient, causes larger injury.Current general treatement is antibiotic therapy or more serious has surgical operation therapy, but the antibiotherapy of Western medicine easily develops immunity to drugs, and is difficult for life-time service, and the adverse effect that causes immunity to reduce to patient body; In addition more existing Chinese medicine preparation effects are not fine yet.
Summary of the invention
Goal of the invention: in order to solve the existing problem of prior art, the invention provides a kind of drug effect significantly, take Chinese drugs agentia of convenient, to be difficult for recurrence treatment otitis media and preparation method thereof.
Technical scheme: for achieving the above object, the present invention is by the following technical solutions: a kind of Chinese drugs agentia for the treatment of otitis media, is comprised of according to quality meter following crude drug: 5～8 parts of Radix abutili indicis, 9～13 parts of Radix Cyanotis vagae, 5～8 parts of Herba Malvastri Coromandeliani, 3～8 parts of Auricled Hedyotis Herbs, 10～20 parts of Flos Loniceraes, 6～9 parts of Radix Rehmanniae Preparata, 12～20 parts of Fructus Momordicaes, 6～12 parts of Borneolum Syntheticums, 5～8 parts of Sanguis Monopteri albis, 10～14 parts of Periostracum Cicadaes, 5～8 parts of Ungula Francolinis.
As a further improvement on the present invention, described each crude drug consumption is composed as follows according to quality meter: 7 parts of Radix abutili indicis, 11 parts of Radix Cyanotis vagae, 7 parts of Herba Malvastri Coromandeliani, 6 parts of Auricled Hedyotis Herbs, 15 parts of Flos Loniceraes, 7 parts of Radix Rehmanniae Preparata, 16 parts of Fructus Momordicaes, 8 parts of Borneolum Syntheticums, 7 parts of Sanguis Monopteri albis, 12 parts of Periostracum Cicadaes, 6 parts of Ungula Francolinis.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, four kinds of crude drug mixing and water addings of Auricled Hedyotis Herb are soaked, water consumption is 8～10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20～25min is boiled in big fire, add again Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum, big fire is boiled after rear continuation decocts 10～15min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, with Sanguis Monopteri albi, together with after filtering residue in step (2) mixes, are added the water of 2～4 times of gross weights to soak, soak 10min after big fire boil, continue to leach medicinal liquid after slow fire boiling 15～20min;
(4) medicinal liquid step (2), (3) being obtained obtains the Chinese drugs agentia of described treatment otitis media after mixing.
For better guaranteeing decocting for Chinese herbal medicine effect, described decoction container is marmite or enamel ware.、
Beneficial effect: a kind of Chinese drugs agentia for the treatment of otitis media provided by the present invention and preparation method thereof, compared with prior art has the following advantages: one side drug effect is remarkable, enhancing patient resistance; Cheap, have no side effect, and preparation method is easy, is suitable for clinical practice, be oral drugs on the other hand, more more convenient than external used medicine use, be difficult for recurrence.
the specific embodiment
Below in conjunction with specific embodiment, the present invention is further described:
Embodiment 1:
Treat a Chinese drugs agentia for otitis media, by following crude drug, according to quality meter, formed: 5 parts of Radix abutili indicis, 9 parts of Radix Cyanotis vagae, 5 parts of Herba Malvastri Coromandeliani, 3 parts of Auricled Hedyotis Herbs, 10 parts of Flos Loniceraes, 6 parts of Radix Rehmanniae Preparata, 12 parts of Fructus Momordicaes, 6 parts of Borneolum Syntheticums, 5 parts of Sanguis Monopteri albis, 10 parts of Periostracum Cicadaes, 5 parts of Ungula Francolinis.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) adopt marmite to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, four kinds of crude drug mixing and water addings of Auricled Hedyotis Herb are soaked, water consumption is 8 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20min is boiled in big fire, add again Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum, big fire is boiled after rear continuation decocts 10min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, with Sanguis Monopteri albi, together with after filtering residue in step (2) mixes, are added the water of 2 times of gross weights to soak, soak 10min after big fire boil, continue to leach medicinal liquid after slow fire boiling 15min;
(4) medicinal liquid step (2), (3) being obtained obtains the Chinese drugs agentia of described treatment otitis media after mixing.
Embodiment 2:
Treat a Chinese drugs agentia for otitis media, by following crude drug, according to quality meter, formed: 7 parts of Radix abutili indicis, 11 parts of Radix Cyanotis vagae, 7 parts of Herba Malvastri Coromandeliani, 6 parts of Auricled Hedyotis Herbs, 15 parts of Flos Loniceraes, 7 parts of Radix Rehmanniae Preparata, 16 parts of Fructus Momordicaes, 8 parts of Borneolum Syntheticums, 7 parts of Sanguis Monopteri albis, 12 parts of Periostracum Cicadaes, 6 parts of Ungula Francolinis.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) adopt marmite to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, four kinds of crude drug mixing and water addings of Auricled Hedyotis Herb are soaked, water consumption is 9 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 22min is boiled in big fire, add again Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum, big fire is boiled after rear continuation decocts 12min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, with Sanguis Monopteri albi, together with after filtering residue in step (2) mixes, are added the water of 3 times of gross weights to soak, soak 10min after big fire boil, continue to leach medicinal liquid after slow fire boiling 18min;
(4) medicinal liquid step (2), (3) being obtained obtains the Chinese drugs agentia of described treatment otitis media after mixing.
Embodiment 3:
Treat a Chinese drugs agentia for otitis media, by following crude drug, according to quality meter, formed: 8 parts of Radix abutili indicis, 13 parts of Radix Cyanotis vagae, 8 parts of Herba Malvastri Coromandeliani, 8 parts of Auricled Hedyotis Herbs, 20 parts of Flos Loniceraes, 9 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Momordicaes, 12 parts of Borneolum Syntheticums, 8 parts of Sanguis Monopteri albis, 14 parts of Periostracum Cicadaes, 8 parts of Ungula Francolinis.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) adopt marmite to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, four kinds of crude drug mixing and water addings of Auricled Hedyotis Herb are soaked, water consumption is 10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 25min is boiled in big fire, add again Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum, big fire is boiled after rear continuation decocts 15min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, with Sanguis Monopteri albi, together with after filtering residue in step (2) mixes, are added the water of 4 times of gross weights to soak, soak 10min after big fire boil, continue to leach medicinal liquid after slow fire boiling 20min;
(4) medicinal liquid step (2), (3) being obtained obtains the Chinese drugs agentia of described treatment otitis media after mixing.
The present invention cures mainly the symptoms such as pharyngotympanic tube, tympanum, tympanic antrum and mastoid air cell that caused by otitis media.By clinical case, further set forth below the beneficial effect of medicine of the present invention:
(1) clinical data and Therapeutic Method
With test group treatment otitis media patient 50 examples, compare with matched group 50 examples.
test group:in the present invention, the Chinese drugs agentia described in embodiment 1-3, is decocted in water for oral dose, every day potion, sooner or later sub-service.Taking medicine continuously 7 days is 1 course for the treatment of;
matched group:adopting conventional medicine to treat, every day three times, 7 days was 1 course for the treatment of.
Test group and matched group patient are fully recovered in 3 months and paid a return visit, investigate and record otitis media disease recurrence.
(2) curative effect determinate standard
A) effective: the transference cures such as the interior erosion of the auricle for the treatment of 5d, otalgia, tinnitus; Ear's swelling hyperemia alleviates, and ear's purulent secretion disappears; Auditory rehabilitation is normal, other concurrent uncomfortable transference cures.
B) effective: the symptoms such as the interior erosion of the auricle for the treatment of 5～7 d, otalgia, tinnitus are clearly better; Ear's swelling hyperemia alleviates, and ear's purulent secretion disappears and obviously alleviates or disappear; Auditory rehabilitation is normal, and other concurrent uncomfortable symptoms obviously alleviate or disappear.
C) invalid: treatment 7 d patient's symptoms and sign, without obviously alleviating, even increase the weight of.
(3) clinical effectiveness
Test group and the comparison of matched group curative effect, in Table 1.
Table 1 test group and the comparison of matched group curative effect
| ? | Effective | Effectively | Invalid | Add up to | Effective percentage (%) | Relapse rate (%) |
| Test group | 32 | 15 | 3 | 50 | 94 | 0 |
| Matched group | 9 | 15 | 26 | 50 | 48 | 25 |
Clinical effectiveness shows: test group treatment otitis media patient 50 examples, total effective rate reaches 0 recurrence in 94%, three month, with the total effective rate of matched group 50 examples 46% and in three months 25% relapse rate compare, be obviously better than matched group.Illustrate that Drug therapy otitis media of the present invention is evident in efficacy, drug effect is remarkable and be difficult for recurrence, has good promotional value.
Should be understood that, the above specific embodiment is only not used in and limits the scope of the invention for the present invention is described, after having read the present invention, those skilled in the art all fall within the application's claims limited range to the modification of the various equivalent form of values of the present invention.
Claims (3)
1. a Chinese drugs agentia for the treatment of otitis media, it is characterized in that, comprise the crude drug of following parts by weight: 5～8 parts of Radix abutili indicis, 9～13 parts of Radix Cyanotis vagae, 5～8 parts of Herba Malvastri Coromandeliani, 3～8 parts of Auricled Hedyotis Herbs, 10～20 parts of Flos Loniceraes, 6～9 parts of Radix Rehmanniae Preparata, 12～20 parts of Fructus Momordicaes, 6～12 parts of Borneolum Syntheticums, 5～8 parts of Sanguis Monopteri albis, 10～14 parts of Periostracum Cicadaes, 5～8 parts of Ungula Francolinis.
2. the Chinese drugs agentia for the treatment of otitis media according to claim 1, it is characterized in that, comprise the crude drug of following parts by weight: 7 parts of Radix abutili indicis, 11 parts of Radix Cyanotis vagae, 7 parts of Herba Malvastri Coromandeliani, 6 parts of Auricled Hedyotis Herbs, 15 parts of Flos Loniceraes, 7 parts of Radix Rehmanniae Preparata, 16 parts of Fructus Momordicaes, 8 parts of Borneolum Syntheticums, 7 parts of Sanguis Monopteri albis, 12 parts of Periostracum Cicadaes, 6 parts of Ungula Francolinis.
3. a preparation method for the Chinese drugs agentia for the treatment of acute otitis media as claimed in claim 1, is characterized in that comprising the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, four kinds of crude drug mixing and water addings of Auricled Hedyotis Herb are soaked, water consumption is 8～10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20～25min is boiled in big fire, add again Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum, big fire is boiled after rear continuation decocts 10～15min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, with Sanguis Monopteri albi, together with after filtering residue in step (2) mixes, are added the water of 2～4 times of gross weights to soak, soak 10min after big fire boil, continue to leach medicinal liquid after slow fire boiling 15～20min;
(4) medicinal liquid step (2), (3) being obtained obtains the Chinese drugs agentia of described treatment otitis media after mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310684316.2A CN103656297B (en) | 2013-12-16 | 2013-12-16 | A kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310684316.2A CN103656297B (en) | 2013-12-16 | 2013-12-16 | A kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof |
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| CN103656297A true CN103656297A (en) | 2014-03-26 |
| CN103656297B CN103656297B (en) | 2016-01-27 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822693A (en) * | 2010-04-29 | 2010-09-08 | 周莹 | Medicine treating tympanitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822693A (en) * | 2010-04-29 | 2010-09-08 | 周莹 | Medicine treating tympanitis |
Non-Patent Citations (2)
| Title |
|---|
| 顾雪冬: "治中耳炎的小验方", 《中国医药报》, 7 April 2003 (2003-04-07), pages 1 * |
| 高拾如: "食用珍禽——美国鹧鸪", 《山西老年》, no. 8, 31 December 1999 (1999-12-31), pages 43 * |
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