CN103610871B - 一种治疗牙周炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗牙周炎的中药组合物。牙周炎在祖国医学中属“牙宣”范畴，齿为骨之余，为肾所主，并为足阳明胃经所络，故与胃、肾关系密切，胃火炽盛及肾亏虚是其主要机理，以滋肾阴、降虚火为治法。本发明选择中药老君须、紫河车、沙苑子、南烛叶、一叶荻、硬飘拂草、麦瓶草、土白蔹、苦石莲、苦碟子、犁头草、青黛，水煎成汤剂，经临床试验，总有效率达到97.9％，明显优于对照组。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗牙周炎的中药组合物。
背景技术
牙周炎是侵犯牙龈和牙周支持组织的慢性破坏性疾病，是口腔两大类主要疾病之一，在世界范围内具有较高的患病率，在我国更为突出。其主要特征为牙周袋形成和袋壁的炎症、牙槽骨吸收和牙齿逐渐松动，是导致成年人牙齿丧失的主要原因，并可导致或诱发多种疾病，严重危害人类健康。牙周炎病因病机较为复杂，病因包括主要致病菌和机体反应性。目前多采用抗生素及局部治疗，但易复发，长期疗效不理想，而且副作用较多，不宜长时间服用，加之近年来病原微生物的抗药性不断增强，使抗生素的疗效日益降低。因此，设法用中医药来提高临床疗效，减少副作用，减少复发，正是人们关注的问题。临床实践表明，中医药治疗牙周炎疗效已逐步得到肯定，未发现副作用。中医的治疗往往着眼于整体的调节作用，注重局部与全身的联系，重视发挥人体的抗病潜能。其“扶正固本”治疗方法，无疑是提高牙周炎病人御病能力，提高机体免疫功能的重要手段，在长期的临床过程中，运用中医药治疗牙周炎已越来越显示出其优势。
发明内容
本发明的目的是提供一种治疗牙周炎的中药组合物。牙周炎在祖国医学中属“牙宣”范畴，齿为骨之余，为肾所主，并为足阳明胃经所络，故与胃、肾关系密切，胃火炽盛及肾亏虚是其主要机理，以滋肾阴、降虚火为治法。
本发明的目的是通过以下技术方案实现的，该治疗牙周炎的中药组合物由以下重量份的中药制成：老君须15-25份、紫河车5-7份、沙苑子9-13份、南烛叶10-15份、一叶荻15-25份、硬飘拂草15-25份、麦瓶草20-24份、土白蔹25-45份、苦石莲7-10份、苦碟子15-25份、犁头草12-16份、青黛1-3份。
优选的：老君须20份、紫河车6份、沙苑子11份、南烛叶12份、一叶荻20份、硬飘拂草20份、麦瓶草22份、土白蔹35份、苦石莲8.5份、苦碟子20份、犁头草14份、青黛2份。
制备方法将上述中药水煎制成汤剂。
方中：老君须补肾健脾，化毒；紫河车补气，养血，益精；沙苑子补肝，益肾，明目，固精；南烛叶益精气，强筋骨；一叶荻活血舒筋，健脾益肾；硬飘拂草滋阴润燥，补虚益损；麦瓶草养阴，和血；土白蔹清热化痰，利湿，散结消肿；苦石莲散瘀止痛，清热去湿；苦碟子、犁头草、青黛清热解毒，排脓，止痛。
临床资料
1.一般资料共观察治疗87例，均为本院口腔科门诊患者，均诊断为牙周炎。随机分为治疗组47例，对照组40例。治疗组中，男28例，女19例；年龄28-61岁；病程最短者1年，最长者18年。对照组中，男20例，女20例；年龄27-65岁；病程最短者1年，最长者19年。两组一般资料比较无显著性差异(P>0.05)，具有可比性。
2.诊断标准牙龈呈现不同程度的慢性炎症，颜色暗红或鲜红，质地松软，点彩消失，边缘圆钝且不与牙面贴附；牙周袋形成，附着丧失，袋内溢脓；牙齿出现不同程度松动。x线显示，牙槽骨有不同程度的吸收。
3.治疗方法治疗组服用本发明所述的中药制剂，称取老君须20g、紫河车6g、沙苑子11g、南烛叶12g、一叶荻20g、硬飘拂草20g、麦瓶草22g、土白蔹35g、苦石莲8.5g、苦碟子20g、犁头草14g、青黛2g，水煎成汤剂，每日一剂，分早、晚2次服用。对照组口服甲硝唑片，每次0.2g，每日3次；阿莫西林，每次0.5g。每日3次。两组均7日为1个疗程，连服3个疗程后统计疗效。
4.疗效标准治愈：症状完全消失，牙周袋深度变浅或恢复正常，牙齿无松动，能正常咀嚼。好转：牙龈轻度充血，出血、疼痛、水肿减轻。无效：变化不明显。
5.治疗效果治疗3个疗程后进行效果评价。治疗组47例，治愈29例(61.7％)，好转17例(36.2％)，无效1例(2.1％)，总有效率97.9％。对照组40例，治愈15例(37.5％)，好转17例(42.5％)，无效8例(20％)，总有效率80％。两组比较，治疗组治愈率、总有效率明显优于对照组，具有可比性。P<0.05。
具体实施方式
实施例一：称取老君须20g、紫河车6g、沙苑子11g、南烛叶12g、一叶荻20g、硬飘拂草20g、麦瓶草22g、土白蔹35g、苦石莲8.5g、苦碟子20g、犁头草14g、青黛2g，将上述中药水煎成汤剂。
实施例二：称取老君须25g、紫河车5g、沙苑子13g、南烛叶10g、一叶荻25g、硬飘拂草15g、麦瓶草24g、土白蔹25g、苦石莲10g、苦碟子15g、犁头草16g、青黛1g，将上述中药水煎成汤剂。
实施例三：称取老君须15g、紫河车7g、沙苑子9g、南烛叶15g、一叶荻15g、硬飘拂草25g、麦瓶草20g、土白蔹45g、苦石莲7g、苦碟子25g、犁头草12g、青黛3g，将上述中药水煎成汤剂。
Claims (2)
1.一种治疗牙周炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：老君须15-25份、紫河车5-7份、沙苑子9-13份、南烛叶10-15份、一叶荻15-25份、硬飘拂草15-25份、麦瓶草20-24份、土白蔹25-45份、苦石莲7-10份、苦碟子15-25份、犁头草12-16份、青黛1-3份，将上述中药水煎制成汤剂。
2.根据权利要求1所述的一种治疗牙周炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：老君须20份、紫河车6份、沙苑子11份、南烛叶12份、一叶荻20份、硬飘拂草20份、麦瓶草22份、土白蔹35份、苦石莲8.5份、苦碟子20份、犁头草14份、青黛2份。
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| RU2606040C2 (ru) * | 2015-04-01 | 2017-01-10 | Ирина Николаевна Усманова | Способ лечения хронического воспаления тканей пародонта и слизистой оболочки с элементами гиперкератоза у лиц молодого возраста |
| CN105031267A (zh) * | 2015-08-27 | 2015-11-11 | 岳源 | 一种医治牙周炎的方剂及制备方法 |
| CN105031269A (zh) * | 2015-08-27 | 2015-11-11 | 岳源 | 治疗牙周炎的药剂及制法 |
| CN105031268A (zh) * | 2015-08-27 | 2015-11-11 | 岳源 | 一种医治牙周炎的药剂及制备方法 |
| CN105031270A (zh) * | 2015-08-27 | 2015-11-11 | 岳源 | 一种防治牙周炎的制剂及制备方法 |
| CN106109778A (zh) * | 2016-07-28 | 2016-11-16 | 佳木斯大学 | 治疗牙周炎的中药组合物及其制备方法和应用 |
| RU2713959C1 (ru) * | 2019-08-19 | 2020-02-11 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ хирургического лечения хронического генерализованного пародонтита |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310707A (zh) * | 2007-05-22 | 2008-11-26 | 海昌生化科技股份有限公司 | 用于口腔的组成物 |
| CN102526526A (zh) * | 2012-01-13 | 2012-07-04 | 李玉芹 | 用于治疗肾阴亏虚型牙周炎的中药、制备方法及给药方式 |
-
2013
- 2013-11-05 CN CN201310582066.1A patent/CN103610871B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101310707A (zh) * | 2007-05-22 | 2008-11-26 | 海昌生化科技股份有限公司 | 用于口腔的组成物 |
| CN102526526A (zh) * | 2012-01-13 | 2012-07-04 | 李玉芹 | 用于治疗肾阴亏虚型牙周炎的中药、制备方法及给药方式 |
Non-Patent Citations (2)
| Title |
|---|
| 补肾固齿丸对大鼠实验性牙周炎牙槽骨重建的影响;丁一等;《第三军医大学学报》;20111130;第33卷(第22期);第2390-2393页 * |
| 补肾固齿丸的研究现状;何丽霞等;《江西中医药》;20090331;第40卷(第03期);第76-78页 * |
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Effective date of registration: 20191203 Address after: 313000 1-C, building 1, No. 656, Qixing Road, high tech Zone, Wuxing District, Huzhou City, Zhejiang Province Patentee after: Huzhou xinbeilian Network Technology Co., Ltd Address before: The 1 group of Wu Yao Zhen Village in Rugao city of Jiangsu Province, 226500 banks in Nantong City Patentee before: Rugao Wu Shan Kang Hospital |
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Effective date of registration: 20200605 Address after: 514000 1st floor, de'ai street, No.106 Ningxin District, Xingning City, Meizhou City, Guangdong Province Patentee after: Meizhou harmonious Biotechnology Co.,Ltd. Address before: 313000 1-C, building 1, No. 656, Qixing Road, high tech Zone, Wuxing District, Huzhou City, Zhejiang Province Patentee before: Huzhou xinbeilian Network Technology Co.,Ltd. |
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Address after: 3 / F, 153 Ningxin Dongfeng Road, Xingning City, Meizhou City, Guangdong Province 514000 Patentee after: Meizhou harmonious Biotechnology Co.,Ltd. Address before: 514000 1st floor, de'ai street, No.106 Ningxin District, Xingning City, Meizhou City, Guangdong Province Patentee before: Meizhou harmonious Biotechnology Co.,Ltd. |