CN103610790B - Liquid and preparation method thereof is wiped in a kind for the treatment of bone diseases external application - Google Patents
Liquid and preparation method thereof is wiped in a kind for the treatment of bone diseases external application Download PDFInfo
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- CN103610790B CN103610790B CN201310634335.4A CN201310634335A CN103610790B CN 103610790 B CN103610790 B CN 103610790B CN 201310634335 A CN201310634335 A CN 201310634335A CN 103610790 B CN103610790 B CN 103610790B
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Abstract
The invention discloses a kind for the treatment of bone diseases external application and wipe liquid and preparation method thereof, it is mainly to make with the raw material that weight portion consists of alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-700 that liquid is wiped in this treating bone diseases external application. Liquid is wiped in treating bone diseases external application of the present invention, and degree of safety is high, side effect is little, concertedness is good, and to the treatment for the treatment of bone diseases, treatment cycle is short, recurrence rate is low, preparation method is simple, can treat both principal and secondary aspect of disease, total effective rate 100%, total cure rate 88%.
Description
Technical field
The invention belongs to the field of Chinese medicines for the treatment of treating bone diseases, particularly a kind ofly prepare taking Chinese herbal medicine as raw materialLiquid and preparation method thereof is wiped in the treating bone diseases external application for the treatment of sclerotin joint property disease.
Technical background
Hyperosteogeny disease is the elderly's disease occurred frequently, and refractory is healed, easily recurrence. Hyperostosis claims againFor hyperplastic osteoarthritis, Osteoarthritis, degenerated arthropathy, senescent arthritis, hypertrophiarthritis,Be due to soft tissue sex change, degenerations such as the cartilage that forms joint, interverbebral disc, ligaments, edge, joint forms spur,The variations such as synovial membrane is plump, and there is osteoclasia, cause insecondary osteoproliferation, cause dysarthrasis, when being subject toDuring to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity; Hyperosteogeny disease is sent out wellThe joint part movable more in cervical vertebra, lumbar vertebrae, hip, knee, heel etc., heavy burden is larger. From the beginning of mostly being single-shot,Can be multiple late period. Clinical primary and Secondary cases two classes of being divided into. Osteoarthrosis pain, the joint stuffiness of changing one's position, numbnessMeciless is cardinal symptom; Two kinds of hyperostosis primary estranged and Secondary cases; The traditional Chinese medical science think this disease and wound, strain,Obstruction of collaterals by blood stasis, the damp evil that is affected by the cold, phlegm resistance, caused by liver and kidney deficiency etc. are relevant. Current treatment protrusion of lumber intervertebral disc,The Chinese medicine of hyperosteogeny disease has a lot, is generally medicine for oral administration, also toxic when curing the disease, and medicine is formerMaterial cost is higher, and treatment cycle is long, and recurrence rate is high, can not effect a permanent cure. Chinese patent CN100998850A public affairsOpened a kind of with rheum officinale, ground bettle, pseudo-ginseng, rhizoma zingiberis, borneol, camphor, notopterygium root, tarragon, peppermint, the root of Chinese wild ginger,Ligusticum wallichii, frankincense, myrrh, the root of Dahurain angelica, Chinese ephedra, dark plum, three how, fructus gleditsiae, the root of Chinese clematis, semen brassicae, radix aconiti agrestis,The 25-component Chinese medicines such as monkshood, paniculate swallowwort, the root of three-nerved spicebush, bark of ash are the treatment protrasion of the lumbar intervertebral disci that makes of raw materialExternally applied drug, this externally applied drug medication is convenient, good effect, but raw materials used kind is many, price, and do not relate toThe research for the treatment of cycle and recurrence rate. Chinese patent CN102670706A disclose a kind of with borneol, camphor,Alumen, realgar, peppermint are the plaster of the treatment osteoproliferation that makes of raw material, cheap, effective, secondary workWith little, but complicated process of preparation.
Summary of the invention
The object of this invention is to provide that a kind of degree of safety is high, side effect is little, concertedness is good, treatment cycle is short, multipleLiquid is wiped in the treating bone diseases external application of the treatment treating bone diseases that the rate of sending out is low, preparation method simple, can treat both principal and secondary aspect of disease.
The preparation method that another object of the present invention is to provide this treating bone diseases external application wipes liquid.
Liquid is wiped in treating bone diseases external application of the present invention, prepares the primary raw material weight portion of described treating bone diseases external application wiping liquidConsist of: alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-800.
Liquid is wiped in treating bone diseases external application of the present invention, and the raw material of preparing described treating bone diseases external application wiping liquid also comprises as followsThe material of weight portion composition: blue stone 2-20.
Liquid is wiped in treating bone diseases external application of the present invention, and the raw material of preparing described treating bone diseases external application wiping liquid also comprises as followsThe material of weight portion composition: iron 2-13.
Liquid is wiped in treating bone diseases external application of the present invention, and described iron comprises the pig iron, iron pin, iron powder.
Liquid is wiped in treating bone diseases external application of the present invention, and the raw material of preparing described treating bone diseases external application wiping liquid also comprises as followsThe material of weight portion composition: safflower 5-20, Radix Angelicae Sinensis 5-20.
Liquid is wiped in treating bone diseases external application of the present invention, prepares the primary raw material weight portion of described treating bone diseases external application wiping liquidConsist of: alumen 10-20, dark plum 10-15, borneol 8-15, balloonflower root 20-30, spring 400-600, blue stone5-12, iron 5-10.
Liquid is wiped in treating bone diseases external application of the present invention, prepares the primary raw material weight portion of described treating bone diseases external application wiping liquidConsist of: alumen 15, dark plum 13, borneol 11, balloonflower root 25, spring 500, blue stone 8, iron pin 7.
The preparation method of liquid is wiped in treating bone diseases external application of the present invention, comprises the steps:
A) prepare raw material;
B) dark plum, balloonflower root are carried out to decocting and boil, obtain decoction liquor;
C) blue stone, alumen, borneol and iron are added to spring and soak, then filter, obtain soak;
D) described decoction liquor and described soak are mixed, stir and concentrate, described in makingLiquid is wiped in treating bone diseases external application.
The preparation method of liquid is wiped in treating bone diseases external application of the present invention, comprises the steps:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, iron, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe the 6-14 of two kinds of raw material gross weights doubly, decoct 3h, filter to obtain decoction liquor 1; The 2nd time institute adds springAmount be two kinds of raw material gross weights 3-7 doubly, decoct 2h, filter to obtain decoction liquor 2; The 3rd time institute addsThe amount of spring is 1-5 times of two kinds of raw material gross weights, decocts 1h, filters to obtain decoction liquor 3; Merging is decoctedBoil liquid 1,2,3, and again filter, gained filtrate is concentrated into former filtrate volume at 35-70 DEG C1/3, obtain concentrate,
C) blue stone, alumen, borneol, the iron of described components by weight percent ratio are added to 30 DEG C of immersions of spring of remainder2-6 hour, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application.
The preparation method of liquid is wiped in treating bone diseases external application of the present invention, comprises the steps:
A) first dark plum, balloonflower root, safflower, Radix Angelicae Sinensis are cleaned, cutting dry, ratio of component is weighed by weight,For subsequent use; By blue stone, alumen, borneol, spring by weight ratio of component weigh, for subsequent use;
B) dark plum, balloonflower root, safflower, the Radix Angelicae Sinensis of described components by weight percent ratio being added to spring decocts 3 times; The 1st timeAdd spring amount be two kinds of raw material gross weights 6-14 doubly, decoct 3h, filter to obtain decoction liquor 1; The2 times add spring amount be two kinds of raw material gross weights 3-7 doubly, decoct 2h, filter to obtain decoction liquor 2;The 3rd time add spring amount be two kinds of raw material gross weights 1-5 doubly, decoct 1h, filter to obtain decoction liquor3; Merge decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into former at 35-70 DEG C1/3 of filtrate volume, obtains concentrate,
C) 30 DEG C of spring that blue stone, alumen, the borneol of described components by weight percent ratio added to remainder soak 2-6Individual hour, then filter, obtain filtrate;
A) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application.
In the present invention, the source of primary raw material used is as follows:
Blue stone (Copper (II) sulfatepentahydrate): natural or made aqueous sulfuric acid copper crystallizationBody, principal component is copper sulphate, normally the blue crystallization (CuSO45H2O) with 5 molecular crystalline water. Taste acid,Pungent, cold in nature. Return through liver, courage. Cure mainly emetic therapy; Go corruption; Removing toxic substances. Main apoplexy; Epilepsy; Larynx numbness; Sore-throat;Sputum is jammed; Noma; Aphtha; Belepharitis ciliaris eye; Hemorrhoid; Pyogenic infections. The phlegm that dispels the wind, disappears stagnant, removing dampness and destroying parasites.Be jammed for wind-heat sputum, epilepsy; Aphtha is controlled in external application, and the eye of wind is red rotten, sore swollen toxin.
Alumen (driedalum): mineral alunite, refines and calcines through processing the crystallization forming. Sour-puckery flavor,Cold in nature. Gui Jing enters lung, spleen, stomach, large intestine. Dissolving phlegm, eliminating dampness, antidiarrheal, hemostasis, removing toxic substances, desinsection.
Dark plum (FructusMume): the almost ripe fruit of rosaceae plant deciduous tree plum, smoke through pyrotechnicsForm. Taste acid, puckery, property is flat. Return through liver, spleen, lung, large intestine. Astringe the lung, puckery intestines, promote the production of body fluid, claming ascaris. WithIn chronic cough of deficiency lung; Abnormal heat polydipsia; Chronic malaria; Rush down for a long time; Dysentery; Have blood in stool; Hematuria; Metrorrhagia; Ascariasis of biliary tract stomachache; VomitTell; Hookworm disease; The external application sore that disappears, controls triangular mass of mucous membrane growing from the inner corner of the eye evagination. Only limbs pain, hemiplegia meciless, enters muscle and bone soft,Enter worm and lie prostrate, enter dead flesh evil meat evil mole and remove, and in the swollen external application of carbuncle.
Borneol (borneol): the resin of Spore density kapur and volatile oil processed goods extract the knot obtainingBrilliant. Taste is pungent, bitter, cool in nature. Return careful, liver, lung. Logical all keys, loose stagnated fire, goes screen improving eyesight, swelling and pain relieving,The loose poison of heat-clearing, loose fire removing toxic substances, the general rheumatism of can faling apart.
Balloonflower root (Platycodongrandiflorus): the dried roots of Campanulaceae balloonflower root. Bitter, pungent, propertyTepor. Enter lung channel. Energy expelling phlegm and arresting coughing, and have a surname's lung, apocenosis effect. A surname's lung, eliminate the phlegm, relieve sore throat, apocenosis,Profit the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility. Cure mainly coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, the fullness sensation in chest side of bodyDysentery stomachache, aphthae, red eye, swell pain, uroschesis bitterly. For coughing with a lot of sputum, uncomfortable in chest not smooth, pharynxBitterly, hoarsen, lung carbuncle pyemesis, sore purulence does not become to burst.
Iron pin (ironneedle): the needle set that wrought iron is made, main containing metal elemental iron, forging pin form iron oxide.Main effect is the flat liver of relieving palpitation, the carbuncle that disappears removing toxic substances, and furunculosis pain is swollen, falls and beats hemostasis.
Safflower (Carthamustinctorius): safflower belongs to the tubular corolla of feverfew. Warm in nature, taste is pungent. LiveBlood stimulates the menstrual flow, blood stasis removing analgesic. For through closing, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, traumatic injury.
Radix Angelicae Sinensis (Angelicasinensis): the root of umbelliferae angelica. Taste is sweet, pungent, and hardship is warm in nature, returnsLiver, the heart, the spleen channel. Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly all cards of the deficiency of blood, irregular menstruation,Through closing, after dry just difficult, the dysentery characterized by blood in the stool of poly-, the uterine bleeding of dysmenorrhoea, abdominal mass knot, asthenia cold abdominalgia, impotence numbness, numbness, intestinesWeight, ulcer sores, injury from falling down.
Beneficial effect of the present invention is:
Liquid is wiped in treating bone diseases external application of the present invention, and degree of safety is high, side effect is little, concertedness is good, to treating bone diseasesTreatment, treatment cycle is short, recurrence rate is low, preparation method is simple, can treat both principal and secondary aspect of disease.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1
Prescription:
Alumen 15g, dark plum 13g, borneol 11g, balloonflower root 25g, spring 500g, blue stone 8g, iron pin 7
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, iron pin, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 10 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 5 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 3 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 50 DEG C, obtains concentratedLiquid,
C) 30 DEG C of spring that the blue stone of described components by weight percent ratio, alumen, borneol, iron pin added to remainder soakSteep 4 hours, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 2
Prescription:
Alumen 10g, dark plum 10g, borneol 8g, balloonflower root 20g, spring 300g, blue stone 5g, pig iron 5g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, the pig iron, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 6 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 3 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 1 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 35 DEG C, obtains concentratedLiquid,
C) 30 DEG C of spring that blue stone, alumen, borneol, the pig iron of described components by weight percent ratio added to remainder soakSteep 2 hours, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 3
Prescription:
Alumen 30g, dark plum 25g, borneol 25g, balloonflower root 45g, spring 700g, blue stone 20g, iron powder13g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, iron powder, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 14 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 7 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 5 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 70 DEG C, obtains concentratedLiquid,
C) 30 DEG C of spring that blue stone, alumen, borneol, the iron powder of described components by weight percent ratio added to remainder soakSteep 6 hours, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 4
Prescription:
Alumen 25g, dark plum 20g, borneol 20g, balloonflower root 35g, spring 600g, blue stone 18g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 12 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 6 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 4 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 62 DEG C, obtains concentratedLiquid,
C) blue stone of described components by weight percent ratio, alumen, borneol, 30 DEG C of spring adding remainder are soaked to 5Individual hour, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 5
Prescription:
Alumen 10g, dark plum 10g, borneol 10g, balloonflower root 15g, spring 400g, blue stone 5g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By courageAlum, alumen, borneol, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 8 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 4 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 2 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 40 DEG C, obtains concentratedLiquid,
C) blue stone, alumen, borneol, the iron of described components by weight percent ratio are added to 30 DEG C of immersions of spring of remainder3 hours, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 6
Prescription:
Alumen 12g, dark plum 11g, borneol 12g, balloonflower root 18g, spring 450g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By witheredAlum, borneol, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 9 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 4 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 1 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 45 DEG C, obtains concentratedLiquid,
C) 30 DEG C of spring that alumen, borneol, the iron of described components by weight percent ratio added to remainder soak 2 littleTime, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 7
Prescription:
Alumen 22g, dark plum 21g, borneol 19g, balloonflower root 33g, spring 560g
Method for making:
A) first dark plum, balloonflower root are cleaned, cutting dry, ratio of component is weighed by weight, for subsequent use; By witheredAlum, borneol, spring by weight ratio of component are weighed, for subsequent use;
B) dark plum, the balloonflower root of described components by weight percent ratio being added to spring decocts 3 times; The 1st time add the amount of springBe 11 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2nd time add springAmount is 5 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rd time institute adds springAmount be 3 times of two kinds of raw material gross weights, decoct 1h, filter to obtain decoction liquor 3; Merging decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into 1/3 of former filtrate volume at 40 DEG C, obtains concentratedLiquid,
C) 30 DEG C of spring that alumen, borneol, the iron of described components by weight percent ratio added to remainder soak 3 littleTime, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 8
Prescription:
Alumen 10g, dark plum 11g, borneol 12g, balloonflower root 16g, spring 480g, blue stone 4g, safflower 9g,Radix Angelicae Sinensis 8g
Method for making:
A) first dark plum, balloonflower root, safflower, Radix Angelicae Sinensis are cleaned, cutting dry, ratio of component is weighed by weight,For subsequent use; By blue stone, alumen, borneol, spring by weight ratio of component weigh, for subsequent use;
B) dark plum, balloonflower root, safflower, the Radix Angelicae Sinensis of described components by weight percent ratio being added to spring decocts 3 times; The 1st timeAdd spring amount be 7 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2ndThe amount of inferior added spring is 4 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rdThe amount of inferior added spring is 2 times of two kinds of raw material gross weights, decocts 1h, filters to obtain decoction liquor 3; CloseAnd decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into former filtrate volume at 42 DEG C1/3, obtain concentrate,
C) 30 DEG C of spring that blue stone, alumen, the borneol of described components by weight percent ratio added to remainder soak 3Hour, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
Embodiment 9
Prescription:
Alumen 26g, dark plum 20g, borneol 21g, balloonflower root 37g, spring 640g, blue stone 16g, safflower 16g,Radix Angelicae Sinensis 17g
Method for making:
A) first dark plum, balloonflower root, safflower, Radix Angelicae Sinensis are cleaned, cutting dry, ratio of component is weighed by weight,For subsequent use; By blue stone, alumen, borneol, spring by weight ratio of component weigh, for subsequent use;
B) dark plum, balloonflower root, safflower, the Radix Angelicae Sinensis of described components by weight percent ratio being added to spring decocts 3 times; The 1st timeAdd spring amount be 13 times of two kinds of raw material gross weights, decoct 3h, filter to obtain decoction liquor 1; The 2ndThe amount of inferior added spring is 6 times of two kinds of raw material gross weights, decocts 2h, filters to obtain decoction liquor 2; The 3rdThe amount of inferior added spring is 3 times of two kinds of raw material gross weights, decocts 1h, filters to obtain decoction liquor 3; CloseAnd decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into former filtrate volume at 58 DEG C1/3, obtain concentrate,
C) 30 DEG C of spring that blue stone, alumen, the borneol of described components by weight percent ratio added to remainder soak 5Hour, then filter, obtain filtrate;
D) filtrate obtaining in step c) is slowly added in the concentrate obtaining in step b), limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application;
E) described treating bone diseases external application is wiped to liquid bottling, mono-bottle of 100ml.
For this situation is described, now further illustrate effect of the present invention by test example as follows:
Test example 1
(1) diagnostic criteria
Neck osteoproliferation: neck portion has strong sensation, limitation of activity, neck activity to have snap sound, painOften, to shoulder and upper limbs radiation, hand and finger have numbness, electric shock sample sensation, can increase the weight of because neck is movable.
Waist hyperosteogeny: lumbar vertebrae and lumbar soft tissue are ached, distending pain, stiff and tired sense, even bend over to be subject toLimit, there is local pain, send out stiff, rear neuralgia, numbness, fiber crops pain, cusalgia, take out pain, string bitterly, to wholeIndividual lower limb radiation.
Knee joint portion osteoproliferation: gonalgia, have sustainability secret anguish, when temperature reduces, pain increases the weight of,Relevant with climate change, after rising morning, come into play, walking for a long time, strenuous exercise or sitting are stood up while starting to walkGonalgia is stiff, slightly movable rear improvement, and upper and lower building difficulty, downstairs time, knee joint feels like jelly, and easily falls down.Pain while crouching, stiff, when serious, joint pain distending pain, limping is walked, and merges rheumatism patient redness and swelling of joints,Deformity, function limitation, stretch bend activity have snap sound, the visible hydrops articuli of some patients were, part have obvious tumefaction,Compression phenomena.
X-ray film: sufferer place normal physiological curvature disappear or anti-sheet, stenosis of disc space, spinal canal stenosis, centrum andFacet joint hyperplasia.
(2) test case standard
Include case history standard in: for accepting osteoproliferation patient 150 examples for medical treatment, age 20-60 year, average 35 years old,Wherein, neck osteoproliferation 60 examples, waist hyperosteogeny 40 examples, knee joint portion osteoproliferation 50 examples.
(3) grouping and methods for the treatment of
By 60 routine neck osteoproliferation patients, be divided at random 30 routine treatment groups and 30 examples are shone to group; By 40Example waist hyperosteogeny patient, is divided into treatment group 20 example and control group 20 examples at random; By 50 routine knee joint portionsOsteoproliferation, is divided into treatment group 25 example and control group 25 examples at random; Thus, described 150 routine osteoproliferations are suffered fromPerson is divided into 75 routine treatment groups and 75 routine control groups at random; Above treatment group is all smeared the embodiment of the present invention 1 and is madeLiquid is wiped in the treating bone diseases external application obtaining, and every day is early, middle and late respectively once, uses continuously two courses for the treatment of, a course for the treatment ofFor surrounding
Above control group: the external application bone wound blood circulation activating plaster (main component: root of bidentate achyranthes safflower borneol turmeric, work of very navigatingNetwork oil), subsides in every three days, take three courses for the treatment of continuously, and be surrounding a course for the treatment of.
(4) observation index
The variation of symptom, sign before and after treatment
(5) curative effect determinate standard
Recovery from illness: sufferer place physiological camber is normal, intervertenral space, canalis spinalis are normal, and centrum and facet joint hyperplasia disappear;
Effective: sufferer place physiological camber obviously recovers, and intervertenral space, spinal canal stenosis obviously alleviate, centrum and little GuanJoint is uprushed, and life is basic to disappear;
Effective: sufferer place physiological camber slightly recovers, and intervertenral space, spinal canal stenosis have the tendency of alleviating, centrum and littleArticular process hyperplasia has disappearance trend;
Invalid: sufferer place normal physiological curvature disappears or anti-sheet, stenosis of disc space, spinal canal stenosis, centrum and littleArticular process hyperplasia.
(6) result of the test
Treatment group and control group to the treatment results of neck osteoproliferation in table 1.
The curative effect comparison to neck osteoproliferation of table 1 treatment group and control group
Efficacy evaluation: as seen from Table 1, in the clinical testing of neck osteoproliferation, treatment group is smeared the present inventionTreating bone diseases external application wipe that liquid is efficient 100%, cure rate 86.7%, and the control group external application bone wound of very navigating is activeCream is efficient 86.7%, cure rate 63.3%, and the curative effect for the treatment of group and control group relatively has highly significant difference(P < 0.01), shows treating bone diseases external application wiping liquid of the present invention to the treated effect of neck osteoproliferation and controlsMore rate is high, and treatment cycle is short. The patient who fully recovers in treatment group is paid a return visit, find in half a year without recidivist.
Treatment group and control group to the treatment results of waist hyperosteogeny in table 2.
The curative effect comparison to waist hyperosteogeny of table 2 treatment group and control group
Efficacy evaluation: as seen from Table 2, in the clinical testing of waist hyperosteogeny, treatment group is smeared the present inventionTreating bone diseases external application wipe that liquid is efficient 100%, cure rate 90%, and the control group external application bone wound blood circulation activating plaster that very navigatesEfficient 90%, cure rate 75%, the curative effect for the treatment of group and control group relatively has highly significant difference (P < 0.01),Show that treated effect and the cure rate of liquid to waist hyperosteogeny wiped in treating bone diseases external application of the present invention high, and controlThe treatment cycle is short. The patient who fully recovers in treatment group is paid a return visit, find in half a year without recidivist.
The treatment results for the treatment of group and control group knee joint portion osteoproliferation is in table 3.
The curative effect comparison to knee joint portion osteoproliferation of table 3 treatment group and control group
Efficacy evaluation: as seen from Table 3, in the clinical testing of knee joint portion osteoproliferation, treatment group is smeared thisThe treating bone diseases external application of invention wipes that liquid is efficient 100%, cure rate 88%, and the control group external application bone wound of very navigating is livedNetwork cream is efficient 84%, cure rate 72%, and the curative effect for the treatment of group and control group relatively has highly significant difference(P < 0.01), shows the treated effect for the treatment of bone diseases external application wiping liquid of the present invention to knee joint portion osteoproliferationHigh with cure rate, and treatment cycle is short. The patient who fully recovers in treatment group is paid a return visit, find in half a year without multipleSend out person.
Treatment group and control group to total treatment results of osteoproliferation in table 4.
The total effects comparison to osteoproliferation of table 4 treatment group and control group
Efficacy evaluation: as seen from Table 4, in total clinical testing of osteoproliferation, treatment group is smeared the present inventionTreating bone diseases external application wipe liquid total effective rate 100%, total cure rate 88%, and the control group external application bone wound of very navigating is livedNetwork cream total effective rate 86.7%, total cure rate 69.3%, the curative effect for the treatment of group and control group relatively has highly significantDifference (P < 0.01), shows that liquid is wiped in treating bone diseases external application of the present invention better to the total effects of osteoproliferation, controlsTreat efficient and cure rate high, and treatment cycle is short.
(7) conclusion
Can find out from table 1-table 4, treatment group is smeared treating bone diseases external application of the present invention and is wiped liquid, cure rate and effectiveRate obviously improves, and the curative effect for the treatment of group and control group relatively has highly significant difference (P < 0.01), and this shows thisIt is evident in efficacy to osteoproliferation that liquid is wiped in the treating bone diseases external application of invention.
Model case 1:
Fan, female, 45 years old. Main suit: right knee joint is swollen, bitterly, swollen, the limitation of activity of spraining, difficulty in walking. ThenMedical to my institute. Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, right side condylus medialis femoris and shinPlatform bone marrow edema inside bone, medial meniscus anterior angle III signal, medial collateral ligament injury, right knee joint is fewAmount hydrops. Treatment: by using the course for the treatment of treating bone diseases external application of the present invention to wipe liquid, using method be every day early, in,Evening, respectively once first clear water was cleaned affected part, then smeared treating bone diseases external application of the present invention and wipe liquid, within 4 weeks, was 1 treatmentJourney. Treat after 1 course for the treatment of, the former pain of patient, the malaise symptoms such as swollen disappear substantially, walking normal, x-rayCheck and show that sufferer place physiological camber recovers to some extent, intervertenral space, spinal canal stenosis alleviate to some extent, centrum and little jointThe life of uprushing is basic to disappear; Treat after 2 courses for the treatment of, the former pain of patient, the malaise symptoms such as swollen disappear, and walking is normal,X-ray inspection shows that sufferer place physiological camber is normal, and intervertenral space, canalis spinalis are normal, and centrum and facet joint hyperplasia disappearLose.
Model case 2:
Wang, man, 63 years old. Main suit: the tired pain of neck is uncomfortable, and increase the weight of night, it is uncomfortable that the back of the body is taken out acid. Have a medical check-up:Vital sign is steady, sanity, and the cooperation of having a medical check-up, x-ray inspection shows that cervical curvature straightens, neck 3-6 centrumsTrailing edge is step sample and changes, and neck 3-7 vertebral rim sclerotin come to a point, neck 5-6 narrowings of intervertebral space. Treatment: pressUse the course for the treatment of treating bone diseases external application of the present invention to wipe liquid, using method is that every day is early, middle and late respectively once, first clearWater is cleaned affected part, then smears treating bone diseases external application of the present invention and wipe liquid, within 4 weeks, is 1 course for the treatment of. Treat 1 treatmentCheng Hou, the former malaise symptoms of patient disappears substantially, and x-ray inspection shows that cervical curvature, intervertenral space recover substantially, vertebraBody pathology takes a turn for the better to some extent; Treat after 2 courses for the treatment of, the former malaise symptoms of patient disappears, and it is normal that intervertenral space recovers, vertebraBody pathology disappears. After half a year, pay a return visit, patient's recovery situation is good, without recurrence.
Model case 3:
Wang, female, 43 years old. Main suit: both sides calcaneum shouting pain, closely increase the weight of on foot more than a year, gone constant, warpMulti-treatment is invalid. Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, X-ray film demonstration bilateral is followedSpur shape hyperplasia. Treatment: by using the course for the treatment of treating bone diseases external application of the present invention to wipe liquid, using method be every day early,In, evening, respectively once first clear water was cleaned affected part, then smear treating bone diseases external application of the present invention and wipe liquid, within 4 weeks, be 1The individual course for the treatment of. Treat after 1 course for the treatment of, the former pain malaise symptoms of patient disappears substantially, substantially can normal activity;Treat after 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, can normal activity. After half a year, pay a return visit patientRecovery situation is good, without recurrence.
Claims (9)
1. a liquid is wiped in treating bone diseases external application, it is characterized in that, prepares described treating bone diseases external application and wipes the former of liquidMaterial weight portion consists of: alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-700;Described treating bone diseases is osteoproliferation.
2. a liquid is wiped in treating bone diseases external application, it is characterized in that, prepares described treating bone diseases external application and wipes the former of liquidMaterial weight portion consists of: alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-700,Blue stone 2-20; Described treating bone diseases is osteoproliferation.
3. a liquid is wiped in treating bone diseases external application, it is characterized in that, prepares described treating bone diseases external application and wipes the former of liquidMaterial weight portion consists of: alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-700,Blue stone 2-20, iron 2-13; Described treating bone diseases is osteoproliferation.
4. liquid is wiped in treating bone diseases external application according to claim 3, it is characterized in that, described iron be the pig iron,Any in iron pin, iron powder.
5. a liquid is wiped in treating bone diseases external application, it is characterized in that, prepares described treating bone diseases external application and wipes the former of liquidMaterial weight portion consists of: alumen 5-30, dark plum 5-25, borneol 4-25, balloonflower root 10-45, spring 300-700,Blue stone 2-20, safflower 5-20, Radix Angelicae Sinensis 5-20; Described treating bone diseases is osteoproliferation.
6. liquid is wiped in treating bone diseases external application according to claim 4, it is characterized in that, prepares described sclerotinThe parts by weight of raw materials that liquid is wiped in disease external application consists of: alumen 10-20, dark plum 10-15, borneol 8-15, balloonflower root20-30, spring 400-600, blue stone 5-12, iron 5-10.
7. liquid is wiped in treating bone diseases external application according to claim 6, it is characterized in that, prepares described sclerotinThe parts by weight of raw materials that liquid is wiped in disease external application consists of: alumen 15, dark plum 13, borneol 11, balloonflower root 25, spring500, blue stone 8, iron pin 7.
8. wipe the preparation method of liquid according to the treating bone diseases external application described in claim 3-4 any one, its featureBe, described method comprises the steps:
A) first dark plum, balloonflower root are cleaned, cutting dry, weigh by described weight portion composition, for subsequent use;Blue stone, alumen, borneol, iron, spring are formed and weighed by weight, for subsequent use;
B) dark plum, the balloonflower root of described weight portion composition being added to spring decocts 3 times; The 1st time add the amount of springBe the 6-14 of two kinds of raw material gross weights doubly, decoct 3h, filter to obtain decoction liquor 1; The 2nd time institute adds springAmount be two kinds of raw material gross weights 3-7 doubly, decoct 2h, filter to obtain decoction liquor 2; The 3rd time institute addsThe amount of spring is 1-5 times of two kinds of raw material gross weights, decocts 1h, filters to obtain decoction liquor 3; Merging is decoctedBoil liquid 1,2,3, and again filter, gained filtrate is concentrated into former filtrate volume at 35-70 DEG C1/3, obtain concentrate,
C) blue stone, alumen, borneol, the iron described weight portion being formed adds 30 DEG C of immersions of spring of remainder2-6 hour, then filter, obtain filtrate;
D) filtrate step being obtained in c) slowly adds in the concentrate that step obtains in b), and limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application.
9. the preparation method of liquid is wiped in treating bone diseases external application according to claim 5, it is characterized in that instituteThe method of stating comprises the steps:
A) first dark plum, balloonflower root, safflower, Radix Angelicae Sinensis are cleaned, cutting dry, composition is weighed by weight,For subsequent use; Blue stone, alumen, borneol, spring are formed and weighed by weight, for subsequent use;
B) dark plum, balloonflower root, safflower, the Radix Angelicae Sinensis of described weight portion composition being added to spring decocts 3 times; The 1st timeAdd spring amount be four kinds of raw material gross weights 6-14 doubly, decoct 3h, filter to obtain decoction liquor 1; The2 times add spring amount be four kinds of raw material gross weights 3-7 doubly, decoct 2h, filter to obtain decoction liquor 2;The 3rd time add spring amount be four kinds of raw material gross weights 1-5 doubly, decoct 1h, filter to obtain decoction liquor3; Merge decoction liquor 1,2,3, and again filter, gained filtrate is concentrated into former at 35-70 DEG C1/3 of filtrate volume, obtains concentrate,
C) blue stone, alumen, the borneol described weight portion being formed adds 30 DEG C of immersion 2-6 of spring of remainderIndividual hour, then filter, obtain filtrate;
D) filtrate step being obtained in c) slowly adds in the concentrate that step obtains in b), and limit edged stirsMix, after completely adding, stir and 30 DEG C airtightly leave standstill 3 hours, make describedLiquid is wiped in treating bone diseases external application.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297757A (en) * | 1999-12-01 | 2001-06-06 | 张云标 | Medicine liquid for treating pain of injury |
| CN1382456A (en) * | 2001-04-24 | 2002-12-04 | 孙玉阶 | Chinese medicine for treating hyperosteogeny and osteophyte |
| CN1442152A (en) * | 2002-03-01 | 2003-09-17 | 李献斌 | Bony spur eczema ointment |
| CN102784348A (en) * | 2012-07-19 | 2012-11-21 | 严间连 | Traditional Chinese medicine composition for treating cervical hyperplasia, and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013048235A2 (en) * | 2011-09-27 | 2013-04-04 | Nameta Sdn Bhd | A medicinal herbal ointment |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297757A (en) * | 1999-12-01 | 2001-06-06 | 张云标 | Medicine liquid for treating pain of injury |
| CN1382456A (en) * | 2001-04-24 | 2002-12-04 | 孙玉阶 | Chinese medicine for treating hyperosteogeny and osteophyte |
| CN1442152A (en) * | 2002-03-01 | 2003-09-17 | 李献斌 | Bony spur eczema ointment |
| CN102784348A (en) * | 2012-07-19 | 2012-11-21 | 严间连 | Traditional Chinese medicine composition for treating cervical hyperplasia, and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 消疽散外敷治疗附骨痈、疽40例临床效验;孙绍良等;《陕西中医学院学报》;19861231;第9卷(第2期);第20-21页 * |
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