CN103562205A - 流感病毒复制的抑制剂 - Google Patents

流感病毒复制的抑制剂 Download PDF

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Publication number
CN103562205A
CN103562205A CN201180066551.2A CN201180066551A CN103562205A CN 103562205 A CN103562205 A CN 103562205A CN 201180066551 A CN201180066551 A CN 201180066551A CN 103562205 A CN103562205 A CN 103562205A
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CN
China
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alkyl
independently
group
optionally
compound
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Pending
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CN201180066551.2A
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English (en)
Chinese (zh)
Inventor
P·S·查里夫森
M·P·克拉克
U·K·班达拉格
H·邓
I·戴维斯
J·P·达菲
L·J·法默
高淮
W·顾
J·M·肯尼迪
M·W·莱德波尔
B·莱德福
F·马尔泰斯
E·佩罗拉
M.W.沃纳梅克
王天生
F·G·萨利图罗
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN103562205A publication Critical patent/CN103562205A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180066551.2A 2010-12-16 2011-12-16 流感病毒复制的抑制剂 Pending CN103562205A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42393310P 2010-12-16 2010-12-16
US61/423,933 2010-12-16
US201161527277P 2011-08-25 2011-08-25
US61/527,277 2011-08-25
PCT/US2011/065389 WO2012083122A1 (en) 2010-12-16 2011-12-16 Inhibitors of influenza viruses replication

Publications (1)

Publication Number Publication Date
CN103562205A true CN103562205A (zh) 2014-02-05

Family

ID=45464909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180066551.2A Pending CN103562205A (zh) 2010-12-16 2011-12-16 流感病毒复制的抑制剂

Country Status (10)

Country Link
US (1) US20130345218A1 (https=)
EP (1) EP2651938A1 (https=)
JP (1) JP2013545818A (https=)
KR (1) KR20130128435A (https=)
CN (1) CN103562205A (https=)
AU (1) AU2011343647A1 (https=)
CA (1) CA2822062A1 (https=)
MX (1) MX2013006840A (https=)
RU (1) RU2013132683A (https=)
WO (1) WO2012083122A1 (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106573920A (zh) * 2014-08-08 2017-04-19 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吲哚
CN106661036A (zh) * 2014-09-08 2017-05-10 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吡咯并嘧啶
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133665A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof
CN108290869A (zh) * 2015-11-27 2018-07-17 爱尔兰詹森科学公司 用于在流感病毒感染中使用的杂环吲哚
CN108727369A (zh) * 2017-04-25 2018-11-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
CN109678738A (zh) * 2018-12-26 2019-04-26 深圳市华先医药科技有限公司 一种合成(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
CN109748915A (zh) * 2015-12-09 2019-05-14 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
CN112063726A (zh) * 2020-09-21 2020-12-11 杭州市疾病预防控制中心 一种用于检测奥司他韦耐药突变的引物、探针及检测方法
CN115698035A (zh) * 2020-04-10 2023-02-03 共晶制药公司 诺如病毒及冠状病毒复制的抑制剂

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WO2006127587A1 (en) * 2005-05-20 2006-11-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
HRP20181272T1 (hr) 2013-11-13 2018-10-05 Vertex Pharmaceuticals Incorporated Postupci priprave inhibitora replikacije virusa influence
EP3082819B1 (en) 2013-12-20 2020-06-17 Signal Pharmaceuticals, LLC Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
EP3277811B1 (en) 2015-04-03 2020-12-23 University of Massachusetts Fully stabilized asymmetric sirna
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
WO2017125506A1 (en) * 2016-01-20 2017-07-27 Janssen Sciences Ireland Uc Aryl substituted pyrimidines for use in influenza virus infection
WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
WO2017133670A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2017133664A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Bicyclic pyridine and pyrimidine derivatives and their use in the treatment， amelioration or prevention of influenza
WO2017133658A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 4, 7-diazaindole and 4, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
WO2017133657A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
CN107759571B (zh) 2016-08-16 2021-03-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
CN109641868B (zh) * 2016-08-30 2021-12-03 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
US10987354B2 (en) 2016-12-15 2021-04-27 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
WO2018127096A1 (en) 2017-01-05 2018-07-12 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
US10927118B2 (en) 2017-03-02 2021-02-23 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
EP3829719B1 (en) 2018-07-27 2025-04-02 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
JP7627042B2 (ja) 2018-08-23 2025-02-05 ユニバーシティー オブ マサチューセッツ Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
US11820985B2 (en) 2019-03-26 2023-11-21 University Of Massachusetts Modified oligonucleotides with increased stability
MX2022001710A (es) 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
JP7837560B2 (ja) 2020-03-26 2026-03-31 ユニバーシティー オブ マサチューセッツ 安定性の向上を有する修飾オリゴヌクレオチドの合成
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

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WO2006069258A1 (en) * 2004-12-20 2006-06-29 Amgen Inc Substituted heterocyclic compounds and methods of use
CN1938303A (zh) * 2004-03-30 2007-03-28 沃泰克斯药物股份有限公司 用作jak和其它蛋白激酶抑制剂的氮杂吲哚
CN102471339A (zh) * 2009-07-15 2012-05-23 雅培制药有限公司 激酶的吡咯并吡啶抑制剂

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CN102471339A (zh) * 2009-07-15 2012-05-23 雅培制药有限公司 激酶的吡咯并吡啶抑制剂

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106573920A (zh) * 2014-08-08 2017-04-19 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吲哚
CN106573920B (zh) * 2014-08-08 2020-11-10 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吲哚
CN106661036A (zh) * 2014-09-08 2017-05-10 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吡咯并嘧啶
CN106661036B (zh) * 2014-09-08 2022-03-15 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吡咯并嘧啶
CN108290869A (zh) * 2015-11-27 2018-07-17 爱尔兰詹森科学公司 用于在流感病毒感染中使用的杂环吲哚
CN108290869B (zh) * 2015-11-27 2021-05-18 爱尔兰詹森科学公司 用于在流感病毒感染中使用的杂环吲哚
CN109748915A (zh) * 2015-12-09 2019-05-14 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
CN109748915B (zh) * 2015-12-09 2021-03-26 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
WO2017133665A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
CN108727369A (zh) * 2017-04-25 2018-11-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
CN108727369B (zh) * 2017-04-25 2023-06-09 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
CN109678738A (zh) * 2018-12-26 2019-04-26 深圳市华先医药科技有限公司 一种合成(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
CN109678738B (zh) * 2018-12-26 2021-11-30 深圳市华先医药科技有限公司 一种合成(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
CN115698035A (zh) * 2020-04-10 2023-02-03 共晶制药公司 诺如病毒及冠状病毒复制的抑制剂
CN112063726A (zh) * 2020-09-21 2020-12-11 杭州市疾病预防控制中心 一种用于检测奥司他韦耐药突变的引物、探针及检测方法

Also Published As

Publication number Publication date
JP2013545818A (ja) 2013-12-26
WO2012083122A8 (en) 2013-12-05
WO2012083122A1 (en) 2012-06-21
MX2013006840A (es) 2014-01-31
CA2822062A1 (en) 2012-06-21
AU2011343647A1 (en) 2013-05-02
EP2651938A1 (en) 2013-10-23
RU2013132683A (ru) 2015-01-27
KR20130128435A (ko) 2013-11-26
US20130345218A1 (en) 2013-12-26

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