CN103520475A - Pharmaceutical composition for treating pruritus cutanea - Google Patents
Pharmaceutical composition for treating pruritus cutanea Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating pruritus cutanea. The pharmaceutical composition, as an oral administration agent, consists of the following traditional Chinese medicinal materials or extract thereof in parts by weight: 10-25 parts of rehmannia root, 10-25 parts of prepared rhizome of rehmannia, 10-25 parts of asparagus fern, 10-25 parts of radix ophiopogonis, 10-15 parts of root bark of peony tree, 10-15 parts of schizonepeta, 5-10 parts of angelica, 5-10 parts of tribulusterrestris, 5-10 parts of periostracum cicada and 5-10 parts of liquorice. The pharmaceutical composition has an excellent itching relieving effect on local or general pruritus cutanea due to various factors, and can be used for reducing the side effect caused by antihistamine medicines or hormone medicines.
Description
[technical field]
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition that is used for the treatment of skin pruritus.
[background technology]
Pruritus (pruritus) is one of common clinically dermatosis, is especially more common in old people.It is characterized by and take pruritus as main, and without primary lesion.Can be divided into clinically two kinds of locality and generals.Pruritus is a kind of conscious pruritus and clinically without the dermatosis of primary lesion.Locality pruritus is common in only conscious pruritus of anus, pudendum or extremity etc., part, there is no erythra, with the passing of time can cause pachyderma, and eczema sample changes.Anal canal and anus around obstinate pruritus are the cardinal symptoms of primary disease, from the beginning of time be generally limited to skin around the rectum pruritus, mostly be paroxysmal, the degree weight of pruritus differs, as do not healed for a long time, what have spreads to scrotum or labia, and between especially stitching before and after perineal position, pruritus more very, night is more remarkable, sometimes as worm climbs, ant walks; Sometimes as mosquito bite, baking, make people be difficult to fall asleep, feel restless, be out of patience.General pruritus systemic all has the sensation of itching everywhere, but is not that whole body is itched simultaneously, often by a place, moves on to another place.The degree of itching is not quite similar, although there is people to think that skin itches, but still can stand, and some patients think that whole body very itches, and needs with ferrum brush brush skin or hot water laundering, until when dermatorrhagia and feels pain and causalgia, tickle and itch just temporarily alleviates.Often, to itch night heavily, patient has a sleepless night and maybe can not sleep peacefully because itching.Due to violent pruritus, constantly scratch, can there is scratching of scratch, blood crusts or strip, sometimes there is eczema sample to change, lichenification or pigmentation.The skin of scratching also easily infects and furuncle and phyma or folliculitis occurs.
The treatment of locality or general pruritus, also has many Therapeutic Method clinically, by oral all kinds of Chinese and western drugses or external use anti pruritic agent, all can make pruritus alleviate and be cured.But wherein approximately having 20～30% pruritus patient is intractable pruritus.Although use, medicine is prolonged more and repeatedly not to show effect, and treatment cost is high, and using method is complicated.
At present, treatment senile skin pruritus generally adopts antihistamine drug or hormone medicine, generally, for local disease, with the antipruritic control skin of calmness secondary, change into principle, select the medicaments such as carbolic acid, Oleum menthae, anaesthesine, salicylic acid, corticosteroids medicine.And for whole body patient, generally use the medicaments such as chlorpromazine, diphenhydramine, procaine, nicotinic acid, Testosterone Propionate.Use the pharmaceutical treatment of doctor trained in Western medicine, not only most of patients can occur heavier adverse side effect as there is aseptic abscess, erythra, hypotension, feel sick in part, vomiting, dizzy, hypoglycemia, low blood calcium and hepatic and renal function injure etc.
[summary of the invention]
The object of the present invention is to provide a kind of pharmaceutical composition that is used for the treatment of skin pruritus, the locality that various factors is caused or general pruritus have good antipruritic effect, reduce the side effect that antihistamine drug or hormone medicine cause.
Object of the present invention can realize by following technical measures:
A kind of pharmaceutical composition that is used for the treatment of skin pruritus, comprise that the Chinese crude drug of following weight portion or its extract form: 5～10 parts, 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～25 parts of Radix Asparagis, 10～25 parts of Radix Ophiopogonis, 10～15 parts of Cortex Moutans, 10～15 parts of Herba Schizonepetae, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes and Radix Glycyrrhizae, described pharmaceutical composition is Oral preparation.
Preferably, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～30 parts of Concha Margaritiferas, 5～15 parts of Semen Ziziphi Spinosaes.
Preferably, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 6～12 parts of Radix Polygalaes, 6～12 parts, Semen Nelumbinis.
Preferably, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Massa Medicata Fermentata.
Preferably, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～20 parts of Fructus Cannabis.
Preferably, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～15 parts of Herba Schizonepetae, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.
Preferably, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts of Fructus Ligustri Lucidi, 10～25 parts of Semen Cuscutae, 10～25 parts of Rhizoma Polygonati Odorati, 5～10 parts, Herba Spirodelae, 5～10 parts of Radix Paeoniae Rubra, 5～10 parts of Rhizoma Chuanxiongs, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.
Preferably, described extract is alcohol extract, water extract or volatile oil.
Preferably, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
Preferably, the dosage form of described external preparation is cataplasma, and the substrate of described cataplasma is made by the raw material of following weight fraction: 30～50 parts of 800～1000 parts of sodium polyacrylate, 500～700 parts of polyvinylpolypyrrolidone, 0～700 part of PVPK30,20～40 parts of dihydroxyaluminum aminoacetates, 5～10 parts of disodium edetate, 3000～5000 parts of glycerol and L-TARTARIC ACIDs.
Compared with prior art, beneficial effect of the present invention is, the locality that pharmaceutical composition of the present invention causes various factors or general pruritus have good antipruritic effect, reduces the side effect that antihistamine drug or hormone medicine cause.
[specific embodiment]
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The present invention is directed to senile skin pruritus, a kind of pharmaceutical composition is proposed, described pharmaceutical composition is Oral preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 5～10 parts, 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～25 parts of Radix Asparagis, 10～25 parts of Radix Ophiopogonis, 10～15 parts of Cortex Moutans, 10～15 parts of Herba Schizonepetae, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes and Radix Glycyrrhizae.
In drug component of the present invention, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Asparagi and Radix Ophiopogonis play a part nourshing Yin and drynsessmoistening prescription; Cortex Moutan can help the Radix Rehmanniae, increases the effect of removing pathogenic heat from blood and toxic substance from the body; Radix Angelicae Sinensis works the promoting the circulation of blood of enriching blood, " control wind and first control blood, blood wind is from going out "; Fructus Atriplicis Sibiricae, Periostracum Cicadae and Herba Schizonepetae play dispelling wind for relieving itching; Radix Glycyrrhizae plays mediation effect to said medicine.
In a preferred version of the present invention, in order to increase the therapeutic effect that improves insomnia simultaneously, also added the Chinese crude drug of following weight portion or its extract to form: 10～30 parts of Concha Margaritiferas, 5～15 parts of Semen Ziziphi Spinosaes.
In a preferred version of the present invention, in order to increase the therapeutic effect that improves cardiopalmus simultaneously, also added the Chinese crude drug of following weight portion or its extract to form: 6～12 parts of Radix Polygalaes, 6～12 parts, Semen Nelumbinis.
In a preferred version of the present invention, in order to increase the therapeutic effect that improves anorexia, loose stool simultaneously, also added the Chinese crude drug of following weight portion or its extract to form: 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Massa Medicata Fermentata.
In a preferred version of the present invention, in order to increase the therapeutic effect that improves constipation simultaneously, also added the Chinese crude drug of following weight portion or its extract to form: 10～20 parts of Fructus Cannabis.
In order to strengthen the therapeutic effect of skin pruritus, in a preferred version of the present invention, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～15 parts of Herba Schizonepetae, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.Oral preparation is combined use with external preparation, and drug effect is more remarkable.
In order to strengthen the therapeutic effect of skin pruritus, in another preferred version of the present invention, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts of Fructus Ligustri Lucidi, 10～25 parts of Semen Cuscutae, 10～25 parts of Rhizoma Polygonati Odorati, 5～10 parts, Herba Spirodelae, 5～10 parts of Radix Paeoniae Rubra, 5～10 parts of Rhizoma Chuanxiongs, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.Oral preparation is combined use with external preparation, and drug effect is more remarkable.
The extract of above-mentioned Chinese crude drug is alcohol extract, water extract or volatile oil; Aforementioned pharmaceutical compositions also can comprise pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.Form and the dosage form of extract are well known to the skilled person.
In order to strengthen the effect of external preparation, the dosage form of above-mentioned external preparation can be made into cataplasma, to increase drug loading, strengthen infiltration, the effect with slow release, the substrate of described cataplasma is made by the raw material of following weight fraction: 30～50 parts of 800～1000 parts of sodium polyacrylate, 500～700 parts of polyvinylpolypyrrolidone, 0～700 part of PVPK30,20～40 parts of dihydroxyaluminum aminoacetates, 5～10 parts of disodium edetate, 3000～5000 parts of glycerol and L-TARTARIC ACIDs.Cataplasma is to skin without allergy, and irritant reaction is low, painless and medicine noresidue while peeling off, and Drug Percutaneous Absorption is high, easy to use.
In pharmaceutical composition of the present invention, each drug introduction is as follows:
The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch.; The effect that Radix Rehmanniae has clearing away heat and cooling blood, tonifying YIN to promote the production of body fluid.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata be scrophulariaceae rehmannia glutinosa plant (formal name used at school: tuber Rehmannia glutinosa), have another name called Radix Rehmanniae Preparata or throw oneself on the ground, through processing, concoct and to form.Conventionally take wine, Fructus Amomi, Pericarpium Citri Reticulatae as adjuvant is through repeatedly steaming and shine, glossy to inside and outside darkish complexion, quality softness is sticky; Section use, or parch to black is used; There is the YIN nourishing of enriching blood effect.
Radix Asparagi: be the tuber of liliaceous plant Radix Asparagi (Radix Asparagi) Asparagus cochin-chinensis (Lour.) Merr.; There is qingfei yihuo, nourshing Yin and drynsessmoistening prescription effect.
Radix Ophiopogonis: be liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus(T.f) dried root of Ker-Gawl.; There is the effect that YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosaAndr., there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
Herba Schizonepetae: dry stem and leaf and spica for labiate Herba Schizonepetae Nepeta cataria Linn Sp., have dispeling the wind, induce sweat, rash, the annoying effect of hemostasis.
Radix Angelicae Sinensis: be umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels, having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Fructus Atriplicis Sibiricae: for zygophyllaceae is annual or the mature fruit of herbaceos perennial Fructus Tribuli Tribulus ter-restris L., there is the effect of suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.
Periostracum Cicadae: exuviae shell while sprouting wings for the larva of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius, has the effect of loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Radix Glycyrrhizae: be dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat., or the root and rhizome of Glycyrrhiza glabra L. G.glabraL., have following effect: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.
Concha Margaritifera: the powder for shellfish nacreous layer, has suppressing the hyperactive liver and subsiding YANG; The arresting convulsion of calming the nerves; The effect of liver heat removing and eyesight improving.
Semen Ziziphi Spinosae: for the seed of Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba var spinosa (Bunge) Hu, collect pit after fruit maturation, remove sarcocarp and nucleocapsid, take out seed, dry.Have nourishing the liver, mind calming, calms the nerves, the effect of arresting sweating.
Radix Polygalae: be the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd..There is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the effect of detumescence.Cure mainly insomnia and dreamful sleep, the diseases such as forgetful palpitation with fear.
Semen Nelumbinis: be the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn., having clears away heart-fire is amusing, spleen reinforcing antidiarrheal, tranquilizing by nourishing the heart improving eyesight, invigorating middle warmer are reposed, and stomach, antidiarrheal controlling nocturnal emission with astringent drugs, the effect of kidney tonifying relieving leukorrhea by astringents are mended in spleen invigorating.
The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..There is invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic, reduces phlegm, and hidroschesis is antiabortive, increases the effect of appetite.
Massa Medicata Fermentata: for after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed, the herbal leaven forming through fermentation, the effect that there is invigorating the spleen and regulating the stomach, helps digestion in adjusting.
Fructus Cannabis: be the core of moraceae plants Fructus Cannabis (Cannabis sativa L.) seed, there is the effect of loosening bowel to relieve constipation.
Rhizoma Coptidis: be the dry rhizome of cohosh Rhizoma Coptidis (Coptis chinensis Franch.), Coptis deltoidea C.Y.Cheng et Hsiao (Coptis deltoidea C.Y.Cheng et Hsiao) and Coptis Teeta Wall (Coptis teeta Wall.), there is heat clearing and damp drying, the effect of eliminating fire and detoxication.
Borneolum Syntheticum: be processed into for the resin of Spore density Borneolum Syntheticum and volatile oil processed goods extract the crystallization obtaining, there is logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain, the loose poison of heat clearing away, the effect of loose fire removing toxic substances.
The Radix Stemonae: the dried root for Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour., has nourishing the lung to arrest cough; The effect of parasite killing delousing.
Fructus Ligustri Lucidi: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi Ligustrum lucidum Ait., there is the effect of clearind deficient heat, improving eyesight.
Semen Cuscutae: be the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam., the plant of gathering during fruit maturation autumn, dries, and lays seed, removes impurity, has nourishing the liver and kidney, and controlling nocturnal emission with astringent drugs reducing urination is antiabortive, improving eyesight, the effect of antidiarrheal.
Rhizoma Polygonati Odorati: be the rhizome of liliaceous plant (Polygonatum odoratum (Mill.) Druce) Rhizoma Polygonati Odorati, there is the effect of tonifying-Yin and nourishing-stomach, promoting the production of body fluid for nourishing the lung, the kidney invigorating.
Herba Spirodelae: be the herb of Lemnaceae (Lemnaceae) plant duckweed spirodela or blue or green duckweed, there is diaphoresis, dispel the wind, row water, heat clearing away, the effect of removing toxic substances.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Rubra Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch, there is the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Rhizoma Chuanxiong: be the rhizome of samphire Rhizoma Chuanxiong Rhizoma Chuanxiong, there is the effect of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.
As shown in table 1 is the concrete content of each component in the pharmaceutical composition of oral medication skin pruritus, wherein, in treatment skin pruritus, embodiment 1～embodiment 4 increases the therapeutic effect that improves insomnia simultaneously, embodiment 5～8 increases the therapeutic effect that improves cardiopalmus simultaneously, embodiment 9～12 increases the therapeutic effect that improves anorexia, loose stool simultaneously, and embodiment 13～14 increases the therapeutic effect that improves constipation simultaneously.
Table 1 is depicted as the concrete content of each component in the pharmaceutical composition of oral medication skin pruritus
As shown in table 2 is the concrete content of each component in the pharmaceutical composition of external preparation in oral and external combined treatment skin pruritus, wherein, in embodiment 15～embodiment 24, oral pharmaceutical composition comprises that the Chinese crude drug of following weight portion or its extract form: 5～10 parts, 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～25 parts of Radix Asparagis, 10～25 parts of Radix Ophiopogonis, 10～15 parts of Cortex Moutans, 10～15 parts of Herba Schizonepetae, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes and Radix Glycyrrhizae.
Table 2 oral with external combined treatment skin pruritus in the concrete content of each component in the pharmaceutical composition of external preparation
As shown in table 3 is the concrete content of each component in the pharmaceutical composition of external preparation in oral and external combined treatment skin pruritus, wherein, in embodiment 25～embodiment 34, oral pharmaceutical composition comprises that the Chinese crude drug of following weight portion or its extract form: 5～10 parts, 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～25 parts of Radix Asparagis, 10～25 parts of Radix Ophiopogonis, 10～15 parts of Cortex Moutans, 10～15 parts of Herba Schizonepetae, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes and Radix Glycyrrhizae.
Table 3 oral with external combined treatment skin pruritus in the concrete content of each component in the pharmaceutical composition of external preparation
Application examples 1
Adopt the medicine composite for curing skin pruritus of embodiment of the present invention 1-14
case selection
From the court, select 35 routine skin pruritus patients, 65 years old mean age, average course of disease 36 months, is divided into experimental group and matched group.
Experimental group: 28 examples adopt embodiment of the present invention 1-14(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
Matched group: 7 examples adopt antihistamine drug for oral administration to treat.
diagnostic criteria
The all cases of the skin pruritus described in the embodiment of the present invention meets the diagnostic criteria of " clinical dermatology " pruritus, exclusion standard: the pruritus that 1. viscera disease such as diabetes, chronic hepatopathy, chronic nephropathy, renal failure, internal tumor, autoimmune disease causes; 2. in 4 weeks, take the immunosuppressant such as Radix Tripterygii Wilfordii; 3. in 1 week, took corticosteroid hormone; 4. there are medicine or food anaphylaxis history person.
therapeutic Method
Experimental group: press every dose of decocting twice of proportioning (every part is 1g) of embodiment 1-14, take medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; Within 10 days, be a course for the treatment of, observe altogether 1-2 the course for the treatment of.
Matched group: take Chlorate, usage: every day 1 time, each 4mg, 10 days was 1 course for the treatment of, before sleeping, took.
During two groups of treatments, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Recovery from illness: skin pruritus symptom is all eliminated;
Effective: the degree of skin pruritus takes a turn for the better 75%～90%;
Effective: the degree of skin pruritus takes a turn for the better 35%～75%;
Invalid: the degree of skin pruritus is not improved.
therapeutic outcome
Experimental group: 15 examples of fully recovering, effective 8 examples, effective 3 examples, invalid 2 examples;
Matched group: 8 examples of fully recovering, effective 12 examples, effective 14 examples, invalid 5 examples.
The cure rate of experimental group and obvious effective rate are obviously better than matched group (P < 0.01).
Application examples 2
Adopt the medicine composite for curing skin pruritus of embodiment of the present invention 15-35
case selection
From the court, select 60 routine skin pruritus patients, 60 years old mean age, average course of disease 36 months, is divided into experimental group and matched group.
Experimental group 1:20 example adopts embodiment of the present invention 15-25(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
Experimental group 2:20 example adopts embodiment of the present invention 25-35(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
Matched group: 20 examples adopt antihistamine drug for oral administration to treat.
diagnostic criteria
The all cases of the skin pruritus described in the embodiment of the present invention meets the diagnostic criteria of " clinical dermatology " pruritus, exclusion standard: the pruritus that 1. viscera disease such as diabetes, chronic hepatopathy, chronic nephropathy, renal failure, internal tumor, autoimmune disease causes; 2. in 4 weeks, take the immunosuppressant such as Radix Tripterygii Wilfordii; 3. in 1 week, took corticosteroid hormone; 4. there are medicine or food anaphylaxis history person.
therapeutic Method
Experimental group 1: oral agents is pressed every dose of decocting twice of proportioning (every part is 1g) of embodiment 15-25, takes medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; External preparation is made into unguentum according to the proportioning of embodiment 25-35 (every part is 1g), is coated with every day 3 times; Within 10 days, be a course for the treatment of, observe altogether 1-2 the course for the treatment of.
Experimental group 2: oral agents is pressed every dose of decocting twice of proportioning (every part is 1g) of embodiment 25-35, takes medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; External preparation is made into unguentum according to the proportioning of embodiment 25-35 (every part is 1g), is coated with every day 3 times; Within 10 days, be a course for the treatment of, observe altogether 1-2 the course for the treatment of.
Matched group: take Chlorate, usage: every day 1 time, each 4mg, 10 days was 1 course for the treatment of, before sleeping, took.
During three groups of treatments, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Recovery from illness: skin pruritus symptom is all eliminated;
Effective: the degree of skin pruritus takes a turn for the better 75%～90%;
Effective: the degree of skin pruritus takes a turn for the better 35%～75%;
Invalid: the degree of skin pruritus is not improved.
therapeutic outcome
Experimental group 1: 11 examples of fully recovering, effective 5 examples, effective 3 examples, invalid 1 example;
Experimental group 2: 10 examples of fully recovering, effective 6 examples, effective 4 examples, invalid 1 example;
Matched group: 4 examples of fully recovering, effective 5 examples, effective 7 examples, invalid 4 examples.
The cure rate of experimental group 1 and experimental group 2 and obvious effective rate are obviously better than matched group (P < 0.01).
Application examples 3
Adopt the medicine composite for curing skin pruritus of embodiment of the present invention 15-25
case selection
From the court, select 60 routine skin pruritus patients, 60 years old mean age, average course of disease 36 months, is divided into experimental group and matched group.
Experimental group 1:20 example adopts embodiment of the present invention 15-25(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition, wherein, external preparation adopts cataplasma, and the substrate of cataplasma is made by the raw material of following weight fraction: 30～50 parts of 800～1000 parts of sodium polyacrylate, 500～700 parts of polyvinylpolypyrrolidone, 0～700 part of PVPK30,20～40 parts of dihydroxyaluminum aminoacetates, 5～10 parts of disodium edetate, 3000～5000 parts of glycerol and L-TARTARIC ACIDs.
Experimental group 2:20 example adopts embodiment of the present invention 15-25(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
Matched group: 20 examples adopt antihistamine drug for oral administration to treat.
diagnostic criteria
The all cases of the skin pruritus described in the embodiment of the present invention meets the diagnostic criteria of " clinical dermatology " pruritus, exclusion standard: the pruritus that 1. viscera disease such as diabetes, chronic hepatopathy, chronic nephropathy, renal failure, internal tumor, autoimmune disease causes; 2. in 4 weeks, take the immunosuppressant such as Radix Tripterygii Wilfordii; 3. in 1 week, took corticosteroid hormone; 4. there are medicine or food anaphylaxis history person.
therapeutic Method
Experimental group 1: oral agents is pressed every dose of decocting twice of proportioning (every part is 1g) of embodiment 15-25, takes medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; External preparation adopts cataplasma, and the substrate of cataplasma is made by the raw material of following weight fraction: 30～50 parts of 800～1000 parts of sodium polyacrylate, 500～700 parts of polyvinylpolypyrrolidone, 0～700 part of PVPK30,20～40 parts of dihydroxyaluminum aminoacetates, 5～10 parts of disodium edetate, 3000～5000 parts of glycerol and L-TARTARIC ACIDs; Within 10 days, be a course for the treatment of, observe altogether 1-2 the course for the treatment of.
Experimental group 2: oral agents is pressed every dose of decocting twice of proportioning (every part is 1g) of embodiment 25-35, takes medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; External preparation is made into unguentum according to the proportioning of embodiment 25-35 (every part is 1g), is coated with every day 3 times; Within 10 days, be a course for the treatment of, observe altogether 1-2 the course for the treatment of.
Matched group: take Chlorate, usage: every day 1 time, each 4mg, 10 days was 1 course for the treatment of, before sleeping, took.
During three groups of treatments, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Recovery from illness: skin pruritus symptom is all eliminated;
Effective: the degree of skin pruritus takes a turn for the better 75%～90%;
Effective: the degree of skin pruritus takes a turn for the better 35%～75%;
Invalid: the degree of skin pruritus is not improved.
therapeutic outcome
Experimental group 1: 15 examples of fully recovering, effective 3 examples, effective 2 examples, invalid 0 example;
Experimental group 2: 10 examples of fully recovering, effective 5 examples, effective 5 examples, invalid 1 example;
Matched group: 5 examples of fully recovering, effective 6 examples, effective 4 examples, invalid 4 examples.
The cure rate of experimental group 1 and obvious effective rate are obviously better than experimental group 2 and matched group (P < 0.01).
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Various other corresponding changes and distortion that any technical conceive according to the present invention is made, all should be included in the protection domain of the claims in the present invention.
Claims (10)
1. a pharmaceutical composition that is used for the treatment of skin pruritus, it is characterized in that, described pharmaceutical composition comprises that the Chinese crude drug of following weight portion or its extract form: 5～10 parts, 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～25 parts of Radix Asparagis, 10～25 parts of Radix Ophiopogonis, 10～15 parts of Cortex Moutans, 10～15 parts of Herba Schizonepetae, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes and Radix Glycyrrhizae, described pharmaceutical composition is Oral preparation.
2. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～30 parts of Concha Margaritiferas, 5～15 parts of Semen Ziziphi Spinosaes.
3. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 6～12 parts of Radix Polygalaes, 6～12 parts, Semen Nelumbinis.
4. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Massa Medicata Fermentata.
5. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～20 parts of Fructus Cannabis.
6. according to the pharmaceutical composition described in claim 1 to 5 any one, it is characterized in that, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts, the Radix Rehmanniae, 10～25 parts, Radix Rehmanniae Preparata, 10～15 parts of Herba Schizonepetae, 5～10 parts of Fructus Atriplicis Sibiricaees, 5～10 parts of Periostracum Cicadaes, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.
7. according to the pharmaceutical composition described in claim 1 to 5 any one, it is characterized in that, described pharmaceutical composition also comprises external preparation, comprises that the Chinese crude drug of following weight portion or its extract form: 15～30 parts of 10～25 parts of Fructus Ligustri Lucidi, 10～25 parts of Semen Cuscutae, 10～25 parts of Rhizoma Polygonati Odorati, 5～10 parts, Herba Spirodelae, 5～10 parts of Radix Paeoniae Rubra, 5～10 parts of Rhizoma Chuanxiongs, 5～10 parts of Rhizoma Coptidis, 15～20 parts of Borneolum Syntheticums and the Radixs Stemonae.
8. according to the pharmaceutical composition described in claim 1 to 5 any one, it is characterized in that, described extract is alcohol extract, water extract or volatile oil.
9. according to the pharmaceutical composition described in claim 1 to 5 any one, it is characterized in that, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
10. according to the pharmaceutical composition described in claim 6 or 7, it is characterized in that, the dosage form of described external preparation is cataplasma, and the substrate of described cataplasma is made by the raw material of following weight fraction: 30～50 parts of 800～1000 parts of sodium polyacrylate, 500～700 parts of polyvinylpolypyrrolidone, 0～700 part of PVPK30,20～40 parts of dihydroxyaluminum aminoacetates, 5～10 parts of disodium edetate, 3000～5000 parts of glycerol and L-TARTARIC ACIDs.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR3046541A1 (en) * | 2016-01-12 | 2017-07-14 | Soc Ind Limousine D'application Biologique | ACTIVE PRINCIPLE OBTAINED FROM OPHIOPOGON JAPONICUS FOR THE TREATMENT OF ATOPIC DERMATITIS |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046541A1 (en) * | 2016-01-12 | 2017-07-14 | Soc Ind Limousine D'application Biologique | ACTIVE PRINCIPLE OBTAINED FROM OPHIOPOGON JAPONICUS FOR THE TREATMENT OF ATOPIC DERMATITIS |
| WO2017121965A1 (en) * | 2016-01-12 | 2017-07-20 | Societe Industrielle Limousine D'application Biologique | Active ingredient obtained from ophiopogon japonicus, for the treatment of atopic dermatitis |
| US11311596B2 (en) | 2016-01-12 | 2022-04-26 | Societe Industrielle Limousine D'application Biologique | Active ingredient obtained from Ophiopogon japonicus for the treatment of atopic dermatitis |
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