CN103479947B - 防治便秘药物的制备方法 - Google Patents
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Abstract
本发明公开了一种防治便秘药物的制备方法包括如下步骤：按重量份取原料药白茅根60份、仙鹤草60份、盐乌草10份、苏叶10份、蒲公英60份、合欢皮15份、炙甘草6份、石斛15份、莱菔子15份、黄芩10份、陈皮10份、白术15份、黄连10份、厚朴10份、酸枣仁15份、薏苡仁60份、砂仁10份、玄参10份，生地15份和麸炒枳实10份备用；浸泡，煎煮，提取滤液；本发明不但能透表泄热、清热解毒，而且还能消食除胀、燥湿除满且行气和胃，具有滋阴,养胃和生津的功效，能促进胃液分泌,助消化。
Description
技术领域
[0001] 本发明涉及中药技术领域，具体为一种防治便秘药物的制备方法。
背景技术
[0002] 便秘是一种常见多发性的疾病，严重影响人们的正常生活，而且往往会诱发其他 疾病，例如当大便排出不畅时，过度用力屏气的话，会增加腹压，血压也同时升高，可诱发心 绞痛、心肌梗死、脑出血、中风猝死等。近年来，便秘造成的心脑血管疾病发作有逐年增多的 趋势；常年便秘会导致生活质量下降，健康受损，甚至引发致命的严重后果。我们国家的中 医认为便秘是大便秘结不通，排便时间延长或欲大便而艰涩不畅的一种病症，主要由燥热 内结、气机郁滞、津液不足和脾肾虚寒所引起。而一般以排便为主要治疗目的西药主要是泻 药类药物，均存在不同程度的毒副作用与不良反映。同时，由于便秘具有反复发作的特点， 在使用泻药治疗会产生耐药性，患者多难以长期接受西药治疗，而且上期吃泻药对身体损 害也很大。
发明内容
[0003] 本发明的目的是为了克服上述现有技术的不足之处，按照中医药理论提供一种防 治便秘药物的制备方法。
[0004] 本发明防治便秘药物的制备方法包括如下步骤：
[0005] 第一步：按重量份取原料药白茅根60份、仙鹤草60份、盐乌草10份、苏叶10份、 蒲公英60份、合欢皮15份、炙甘草6份、石斛15份、莱菔子15份、黄芩10份、陈皮10份、 白术15份、黄连10份、厚朴10份、酸枣仁15份、薏苡仁60份、砂仁10份、玄参10份，生地 15份和麸炒枳实10份备用；
[0006] 第二步：将上述原料药混合后进行浸泡，然后分多次加水煎煮，每次煎煮后过滤掉 药渣提取滤液；
[0007] 第三步：合并上述滤液，将滤液冷却至30度以下后装瓶密封。
[0008] 在第二步中：第一次煎煮时，加水量为药物重量的12倍，浸泡时间为1小时，煎煮 时间为1小时；第二次煎煮时，加水量为药物重量的8倍，煎煮时间为0. 5小时；第三次煎煮 时，加水量为药物重量的4倍，煎煮时间为20分钟。
[0009] 各味原料药的药效如下：
[0010] 白矛根：具有凉血止血，清热解毒的功效。
[0011] 仙鹤草：具有收敛止血，止痢，杀虫的功效。
[0012] 盐乌草：具有治疗大腹水肿，休息痢、长期下血的功效。
[0013] 苏叶：具有解表散寒，行气和胃的功效。
[0014] 蒲公英：具有清热解毒、消肿散结的功效。
[0015] 合欢皮：具有解郁、和血、宁心、消痈肿的功效。
[0016] 炙甘草：具有益气滋阴，通阳复脉的功效。
[0017] 石斛：具有滋阴，养胃，生津的功效，能促进胃液分泌，助消化。
[0018] 莱菔子：具有消食除胀，降气化痰的功效，用于饮食停滞、脘腹胀痛、大便秘结、积 滞泻痢、痰壅喘咳。
[0019] 黄芩：具有清热燥湿，凉血安胎，解毒的功效。
[0020] 陈皮：具有温胃散寒、理气健脾的功效。
[0021] 白术：具有健脾益气，燥湿利水，止汗，安胎的功效。
[0022] 黄连：具有泻火，燥湿，解毒，杀虫的功效。
[0023] 厚朴：具有燥湿除满、下气消积、消痰平喘的功效。
[0024] 酸枣仁：具有养肝，宁心，安神，敛汗的功效。
[0025] 薏苡仁：具有健脾渗湿，除痹止泻的功效。
[0026] 砂仁：具有化湿开胃，温脾止泻，理气安胎的功效。
[0027] 麸炒枳实：具有健脾胃、祛宿食的功效。
[0028] 玄参：具有凉血滋阴，泻火解毒的功效。
[0029] 生地：具有清热、生津、润燥、滑肠的功效。
[0030] 本发明不但能透表泄热、清热解毒，而且还能消食除胀、燥湿除满且行气和胃，具 有滋阴，养胃和生津的功效，能促进胃液分泌，助消化。本发明一个重要特点是能防止阴 阳失衡，根据中医组方原则配伍有合适比例的收敛止痢，除痹止泻的药物。本发明另一个重 要特点是纯中药制剂，具有预防和治疗双管齐下的效果，简便易行，费用低，无毒副作用、不 良反应小。
[0031] 为表明本发明对便秘的防治效果，本发明经110例系统临床观察，从华中科技大 学附属同济医院选取已经确诊的成年便秘患者为观察对象，选取的病例过程中排除了肠道 器质性疾病患者，按照肠道实热、肠道气滞、脾虚气弱、脾肾阳虚和阴虚肠燥五类证候选取 五组患者，每组22人，共110例，其中男性60例，女50例，年龄35-70岁，病程3个月至35 年。患者的主要症状为轻者排便时间延长，二天以上一次，粪便干燥坚硬；重者大便艰难，干 燥如栗，伴少腹胀急，神倦乏力，胃纳减退。
[0032] 服用方法：对观察对象口服实施例的口服液，每日三次，一次一剂200ml，3天为一 疗程，观察期半个月，共五个疗程。
[0033] 服药期间中医证候与临床疗效观察分析结果如下：
[0034]
[0035] 疗效评定标准如下：
[0036] 1、治愈：2天以内排便1次，便质转润，解时通畅，短期无复发。
[0037] 2、好转：3天以内排便，便质转润，排便欠畅。
[0038] 3、未愈：症状无改善。
[0039] 从上表中可以看出本发明临床总有效率94. 55%，并且在观察期间未发现有明显的 毒副作用。
具体实施方式
[0040] 本发明防治便秘药物的制备方法包括如下步骤：
[0041] 第一步：按重量份取原料药白茅根60g、仙鹤草60g、盐乌草10g、苏叶10g、蒲公英 60g、合欢皮15g、炙甘草6g、石斛15g、莱菔子15g、黄苳10g、陈皮10g、白术15g、黄连10g、 厚朴10g、酸赛仁15g、薏该仁60g、砂仁10g、玄参10g，生地15g和麸炒枳实IOg备用；
[0042] 第二步：将上述原料药混合后进行浸泡，然后分多次加水煎煮，每次煎煮后过滤掉 药渣提取滤液；
[0043] 第三步：合并上述滤液，将滤液冷却至30度以下后装瓶密封。
[0044] 在第二步中：第一次煎煮时，加水量为药物重量的12倍，浸泡时间为1小时，煎煮 时间为1小时；第二次煎煮时，加水量为药物重量的8倍，煎煮时间为0. 5小时；第三次煎煮 时，加水量为药物重量的4倍，煎煮时间为20分钟。以上为一剂，每日三次，一次一剂200ml， 3天为一疗程，共五个疗程。
Claims (2)
1. 一种防治便秘药物的制备方法，其特征在于包括如下步骤： 第一步：按重量份取原料药白茅根60份、仙鹤草60份、盐乌草10份、苏叶10份、蒲公 英60份、合欢皮15份、炙甘草6份、石斛15份、莱菔子15份、黄芩10份、陈皮10份、白术 15份、黄连10份、厚朴10份、酸枣仁15份、薏苡仁60份、砂仁10份、玄参10份，生地15份 和麸炒枳实10份备用； 第二步：将上述原料药混合后进行浸泡，然后分多次加水煎煮，每次煎煮后过滤掉药渣 提取滤液； 第三步：合并上述滤液，将滤液冷却至30度以下后装瓶密封。
2. 根据权利要求1所述的防治便秘药物的制备方法，其特征在于在第二步中：第一次 煎煮时，加水量为药物重量的12倍，浸泡时间为1小时，煎煮时间为1小时；第二次煎煮时， 加水量为药物重量的8倍，煎煮时间为0. 5小时；第三次煎煮时，加水量为药物重量的4倍， 煎煮时间为20分钟。
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