CN103445808A - Main artery non-invasive continuous blood pressure measuring method and device thereof - Google Patents

Main artery non-invasive continuous blood pressure measuring method and device thereof Download PDF

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CN103445808A
CN103445808A CN2013104164843A CN201310416484A CN103445808A CN 103445808 A CN103445808 A CN 103445808A CN 2013104164843 A CN2013104164843 A CN 2013104164843A CN 201310416484 A CN201310416484 A CN 201310416484A CN 103445808 A CN103445808 A CN 103445808A
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large artery
artery trunks
blood vessel
described
blood pressure
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CN2013104164843A
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CN103445808B (en
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王丛知
郑海荣
曾成志
肖杨
杨戈
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深圳先进技术研究院
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/485Diagnostic techniques involving measuring strain or elastic properties

Abstract

The invention relates to a main artery non-invasive continuous blood pressure measuring method. The method comprises the following steps: emitting a first ultrasonic beam and a second ultrasonic beam to a region of a main artery blood vessel to be measured and collecting an echo signal; extracting shear wave from the echo signal and calculating the feature value of the shear wave spread along the wall of the main artery blood vessel; calculating the transient elasticity modulus of the wall of the main artery blood vessel according to the feature value; obtaining the continuous variation waveform of the diameter of the main artery blood vessel or the cross section area of the main artery blood vessel according to the echo signal; calculating the continuous variation waveform of the blood pressure of the main artery according to the transient elasticity modulus of the wall of the main artery blood vessel and the continuous variation waveform of the diameter of the main artery blood vessel or the cross section area of the main artery blood vessel; and calculating the continuous blood pressure waveform of the main artery. The main artery non-invasive continuous blood pressure measuring method can be applied to measurement of the blood pressure of main arteries such as carotid artery and achieves an important clinical value. In addition, the invention also provides a main artery non-invasive continuous blood pressure measuring device.

Description

Large artery trunks noinvasive continuous BP measurement method and device thereof

Technical field

The present invention relates to the blood pressure measurement field, particularly relate to a kind of large artery trunks noinvasive continuous BP measurement method and device thereof.

Background technology

The cardiovascular diseases is " the No.1 killer " who threatens the human life always.According to World Health Organization's statistics, within 2008, the whole world has 1,700 ten thousand people of surpassing to die from the cardiovascular diseases, and 3,000,000 the dead's age less than of surpassing 60 years old wherein arranged.The cardiovascular diseases is also always in occupation of the first place of China's cause of death.2009, China died from about 3,000,000 people of cardiovascular patient, accounts for 41% of total cause of death.Population of China cardiovascular diseases's morbidity and mortality rate are lasting rising situation, estimate that whole nation trouble cardiovascular diseases number reaches 2.3 hundred million, just has 1 people to suffer from the cardiovascular diseases in every 5 adults.How early warning cardiovascular diseases's generation, reduce pernicious cardiovascular diseases's M & M, is a hot issue of hematodinamics and clinic study always.In numerous hemodynamic parameters or early warning index, arteriotony and arterial blood tube wall elasticity are to weigh two important indicators of cardiovascular system initiation potential degree.More and more research shows, arterial sclerosis can improve hypertensive incidence probability, and closely related with coronary artery pathological changes.Simultaneously, hypertension and arteriosclerosis all can further increase the risk that myocardial infarction and apoplexy occur, and the main cause of the two to be the cardiovascular diseases cause sudden death and other serious consequences.Therefore, Europe and China have all included both in the guideline of prevention and treatment for the cardiovascular diseases in.In fact, have closely and contact between arteriotony variation and arterial blood tube wall transient state elasticity.In a cardiac cycle, the arteries diameter changes continuously under the effect of blood pressure, and the architectural feature of arterial blood tube wall has determined that its transient state elastic modelling quantity also nonlinear change can occur thereupon.Therefore, realize the non-invasive measurement to arteriotony continuous wave and blood vessel wall transient state elastic modelling quantity, hematodinamics research and cardiovascular diseases's control all is of great significance.

Continuous blood pressure waveform is measured, and the information about blood circulation ruuning situation can be provided more, and the control tool of cardiovascular disease is had very important significance.In hematodinamics research and clinical operation treatment, mostly still adopt and have the wound method to carry out the continuous measurement of arteriotony waveform at present.Although it is high that invasive blood pressure is measured accuracy, also makes the patient face the risk of wound and infection.Gradually severe along with cardiovascular disease generation situation, and the carrying out in a deep going way of preventing and controlling, more and more urgent to the requirement of noninvasive continuous blood pressure waveform and transient state blood pressure values measuring method.And existing non-invasive blood pressure measuring method can only provide the discrete numerical value such as systolic pressure, diastolic pressure mostly, can not provide the continuous blood pressure waveform.Although some method can provide the continuous blood pressure waveform, but can only and can not be applied to large artery trunks, as brachial artery, femoral artery, carotid artery etc., go up for peripheral arterial as the finger tremulous pulse, even application reluctantly, the accuracy of measuring is also lower, can't in clinical practice, promote on a large scale.Based on this, the present invention proposes a kind of large artery trunks noinvasive continuous BP measurement method of the ultrasonic instantaneous measurement technology based on arterial blood tube wall elastic modelling quantity and blood vessel diameter.

Existing measuring method that can non-invasive measurement continuous blood pressure waveform comprises several as follows: 1. tonometer method.The method is placed on tremulous pulse top by a pressure transducer, tremulous pulse must relatively shallow table and below have firm background to support, such as skeleton.External pressure perpendicular to bone surface is applied on tremulous pulse, by extruding, makes its Oscillation Amplitude produced with heart beating reach maximum, this means that the arterial blood tube wall is similar in no-load condition.In this state, the continuous pressure waveform that pressure transducer records can amplify and be similar to real intravascular pressure variation by calibration.But this method requires pressure transducer must strictly aim at the tremulous pulse axis, and all must recalibrate different patients, accuracy is also lower, to clinical practice, brings very large difficulty.2. estimate based on infrared light the volumetric blood penalty method that volumetric blood changes and the air bag external trace is pressurizeed.The method be existing rare several can the method for non-invasive measurement continuous blood pressure waveform in, relatively successful a kind of of clinical practice.Its Fundamentals of Measurement is that the infrared light of certain wavelength is incided in the soft tissue of blood vessel near zone, through the tissue and the arteries that contain blood, reflect again or transmit, (relation is inversely proportional to as the index that represents volumetric blood to using measured reflection/transmission infrared light intensity, volumetric blood is larger, and the infrared light intensity obtained is more weak.Because incident and the reflection/transmission degree of depth of infrared light are very shallow, affected by organizational structure larger, volumetric blood penalty method based on this, can only be for pointing the arteriolar continuous BP measurements of periphery such as tremulous pulse.And research shows, the blood pressure waveform in finger place small artery and the difference of aortic blood pressure waveform are very large, and clinical use value also is far smaller than large artery trunks.Simultaneously, because the relation of infrared signal and volumetric blood itself is just very complicated, its quantitative relationship fails to obtain clear and definite research always, the infrared light intensity of measuring gained is not a signal that volumetric blood changes that represents with quantitative measurement meaning, even improve one's methods so follow-up, attempt using it for the wrist place than the large artery trunks radial artery, also can not reflect accurately the vessel diameter change of radial artery, surround lighting and other peripheral petty actions have wherein been comprised, in vein blood vessel, volumetric blood changes impact on it (this result is drawn by applicant's research, and delivered in 2010, Wang CZ and Zheng YP.Comparison between reflection-mode photoplethysmography and arterial diameter change detected by ultrasound at the region of radial artery, Blood Pressure Monitoring, Vol.15 (4), pp.213-219, 2010).The reflection/transmission light intensity signal can only, as an inaccurate approximate evaluation of relative volumetric blood variable quantity, finally will cause measured blood pressure waveform accuracy seriously to reduce.3. and indirectly measurement but indirect calculation goes out the method for continuous blood pressure waveform.Such as J.M.Meinders, and A.P.G.Hoeks, " Simultaneous assessment of diameter and pressure waveforms in the carotid artery; " Ultrasound in Medicine and Biology, 30,147-154, report in 2004 documents such as grade.This method is used the echo tracking technology of ultrasonic radiofrequency signal to obtain the continuous variation waveform of artery diameter or cross-sectional area, again by setting up the empirical equation (generally being assumed to be the exponential relationship of natural logrithm) of " blood pressure-blood vessel diameter (cross-sectional area) " relation, and then extrapolate continuous blood pressure waveform.Concerning the arterial blood tube wall, the changes delta P of arteriotony is equivalent to effect stress thereon, the changes delta D of its diameter or cross-sectional area or Δ S are equivalent to the stress effect and the strain that produces, and what determine relation between stress and strain is the transient state elastic modelling quantity of arterial blood tube wall.The transient state elastic modelling quantity of arterial blood tube wall is constantly to change with the variation of blood pressure in a cardiac cycle, and this variation relation is nonlinear." blood pressure-blood vessel diameter (the cross-sectional area) " relation formula used in this method, the analytical function relation of utilizing hypothesis approximate to a kind of experience of non-linear relation between the arterial blood tube wall transient state elastic modelling quantity that is difficult to measure and blood pressure, be a kind of subjective guess in essence, accuracy does not guarantee.Although the measurement result of this method was once repeatedly compared with the measurement result of invasive blood pressure, but because its theoretical basis---" blood pressure-blood vessel diameter (cross-sectional area) " relation formula---not is based on the mathematical derivation gained of hematodinamics physical model, be difficult to avoid the impact of individual variation on set empirical equation, also be difficult to guarantee the accuracy of measurement result, therefore never extensive use clinically.

Summary of the invention

Based on this, be necessary to provide a kind of accuracy higher and can be widely used in clinical large artery trunks noinvasive continuous BP measurement method and device thereof.

A kind of large artery trunks noinvasive continuous BP measurement method, comprise the steps:

Launch the first ultrasonic beam to large artery trunks blood vessel to be measured region, make the soft tissue generation of vibration shearing wave of large artery trunks blood vessel to be measured region;

Launch the second ultrasonic beam to large artery trunks blood vessel to be measured region, and collect the echo-signal that the second ultrasonic beam causes;

Obtain described shearing wave, and calculate the eigenvalue that described shearing wave is propagated along the large artery trunks blood vessel wall;

The eigenvalue calculation of propagating along the large artery trunks blood vessel wall according to described shearing wave goes out the transient state elastic modelling quantity of large artery trunks blood vessel wall;

Obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to described echo-signal;

Go out the continuous variation waveform of large artery trunks internal blood pressure according to the transient state elastic modelling quantity of described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or the long-pending continuous variation waveshape of large artery trunks vessel cross-sections; And

Obtain auterial diastole and press, and the continuous variation waveform based on the large artery trunks internal blood pressure and auterial diastole are pressed and calculated large artery trunks continuous blood pressure waveform.

Therein in embodiment, the shearing wave that the described soft tissue vibration extracted from described echo-signal by large artery trunks blood vessel to be measured region forms, and calculate described shearing wave and comprise along the step of the eigenvalue of large artery trunks blood vessel wall propagation:

Calculate shearing velocity of wave propagation and the shearing wave amplitude attenuation curve with propagation distance.

Therein in embodiment, the described step that obtains large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to described echo-signal comprises:

Obtain the change in displacement waveform of large artery trunks blood vessel wall according to echo-signal based on the echo position algorithm for estimating; And

Obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to the displacement waveform of large artery trunks blood vessel wall.

Therein in embodiment, in the step of the described change in displacement waveform that obtains the large artery trunks blood vessel wall based on the echo position algorithm for estimating according to echo-signal, described echo position algorithm for estimating comprises that normalized crosscorrelation Time Delay Estimation Method, absolute difference summation Time Delay Estimation Method, normalized covariance Time Delay Estimation Method, non-normalized cross-correlation Time Delay Estimation Method, difference of two squares summation Time Delay Estimation Method, mixed signs cross-correlation Time Delay Estimation Method, polarity overlap Time Delay Estimation Method and Meyr-Spies Time Delay Estimation Method.

In embodiment, the step that the long-pending continuous variation waveshape of the described elastic modelling quantity of the transient state according to described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or large artery trunks vessel cross-sections goes out the continuous variation waveform of large artery trunks internal blood pressure realizes by following formula therein:

ΔP∝ΔD*E????or????ΔP∝ΔS*E;

Wherein, Δ P means the variable quantity of large artery trunks internal blood pressure, and Δ D means the variable quantity of large artery trunks blood vessel diameter, and Δ S means the variable quantity that the large artery trunks vessel cross-sections is long-pending, and E means the transient state elastic modelling quantity of large artery trunks blood vessel wall.

In addition, also be necessary to provide a kind of large artery trunks noinvasive continuous blood pressure measurer, comprise ultrasonic output/input module, ultrasound emission/receiver module, control/communication module and signal processing module, described ultrasonic output/input module and ultrasound emission/receiver module are connected to each other, described ultrasound emission/receiver module and control/communication module are connected to each other, and described control/communication module is connected to signal processing module;

Described ultrasonic output/input module is for launching ultrasonic beam and receiving echo-signal to large artery trunks blood vessel to be measured region, described ultrasound emission/receiver module is for generation of ultrasonic beam and receive the echo-signal received by described ultrasonic output/input module, described control/communication module is for controlling ultrasound emission/receiver module and signal processing module, and described signal processing module is for the treatment of echo-signal and calculate large artery trunks continuous blood pressure waveform.

Therein in embodiment, described large artery trunks noinvasive continuous blood pressure measurer also comprises the human-computer interaction interface module, described human-computer interaction interface module and control/communication module are connected to each other, and described human-computer interaction interface module is connected in signal processing module, for receiving outside input instruction, also for exporting large artery trunks continuous blood pressure oscillogram.

Therein in embodiment, the linear array that described ultrasonic output/input module is many array elements or protruding battle array ultrasonic probe.

In embodiment, described control/communication module, signal processing module and human-computer interaction interface module integration are in the hardware handles platform therein, and described hardware handles platform is computer, single-chip microcomputer, FPGA or dsp chip.

Therein in embodiment, also be connected with mould/number conversion module between described hardware handles platform and ultrasound emission/receiver module, the echo-signal that described mould/the number conversion module receives ultrasound emission/receiver module is converted to digital signal and transfers to the hardware handles platform.

Above-mentioned large artery trunks noinvasive continuous BP measurement method and device thereof, the shearing velocity of wave propagation of bringing out by measuring the first ultrasonic beam, calculate the transient state elastic modelling quantity of large artery trunks blood vessel wall, obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to echo-signal, the last transient state elastic modelling quantity according to described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or the long-pending continuous variation waveshape of large artery trunks vessel cross-sections go out the continuous variation waveform of large artery trunks internal blood pressure simultaneously.Therefore above-mentioned large artery trunks noinvasive continuous BP measurement method and device thereof can be applied to the measurement of the aortic pressures such as carotid artery, have prior clinical value.

The accompanying drawing explanation

The flow chart of the large artery trunks noinvasive continuous BP measurement method that Fig. 1 is an embodiment;

The displacement diagram of the large artery trunks blood vessel front and rear wall that Fig. 2 is an embodiment;

The continuous variation oscillogram of the large artery trunks blood vessel diameter that Fig. 3 is an embodiment;

The module map of the large artery trunks noinvasive continuous blood pressure measurer that Fig. 4 is an embodiment;

Fig. 5 be an embodiment ultrasonic probe is aimed to the schematic diagram of large artery trunks blood vessel.

The specific embodiment

The problem that is difficult to extensive use clinically in order to solve current large artery trunks noinvasive continuous BP measurement method or device, present embodiment provides a kind of large artery trunks noinvasive continuous BP measurement method and device thereof.Below in conjunction with specific embodiment, large artery trunks noinvasive continuous BP measurement method is specifically described.

Please refer to Fig. 1, the large artery trunks noinvasive continuous BP measurement method that present embodiment provides, comprise the steps:

Step S110: launch the first ultrasonic beam to large artery trunks blood vessel to be measured region, make the soft tissue generation of vibration shearing wave of large artery trunks blood vessel to be measured region.In this step, utilize ultrasonic output/input module to launch one or more ultrasonic beams to large artery trunks blood vessel to be measured region.First ultrasonic beam of launching will be enough on arterial blood tube wall to be measured or near zone produces acoustic radiation force.The acoustic radiation force produced will be enough to promote stressed tissue (comprising arterial blood tube wall or arteries surrounding soft tissue) and be subjected to displacement.The degree of displacement of the stressed tissue be subjected to displacement will be enough to as vibration source, causes the surrounding tissue vibration, thereby form shearing wave, to all directions, propagates.In addition, also comprise before this step and adjust ultrasonic output/input module, make ultrasonic output/input module aim at the step of large artery trunks blood vessel region.The detailed process of this alignment procedures is to adjust ultrasonic output/input module, make ultrasonic output/input module perpendicular or parallel in the large artery trunks vessel axis to.

Step S120: launch the second ultrasonic beam to large artery trunks blood vessel to be measured region, and collect the echo-signal that the second ultrasonic beam causes.In this step, second ultrasonic beam of launching requires not cause that the tissue in large artery trunks blood vessel to be measured region is subjected to displacement, thereby guarantee that the second ultrasonic beam can not bring out new shearing wave, to guarantee the echo-signal gathered, only comprise the displacement information of the shearing wave produced in step S110.

Step S130: the soft tissue extracted from described echo-signal by large artery trunks blood vessel to be measured region vibrates the shearing wave formed, and calculates the eigenvalue that described shearing wave is propagated along the large artery trunks blood vessel wall.In this step, by the analyzing and processing to echo-signal, extract the displacement information that large artery trunks blood vessel to be measured region tissue propagate to occur due to shearing wave from echo-signal, and calculate accordingly the eigenvalue that shearing wave propagates along the large artery trunks blood vessel wall (calculate eigenvalue that shearing wave propagates along the large artery trunks blood vessel wall comprise calculating shear velocity of wave propagation and shearing wave amplitude with the attenuation curve of propagation distance etc.).

Step S140: the eigenvalue calculation of propagating along the large artery trunks blood vessel wall according to described shearing wave goes out the transient state elastic modelling quantity of large artery trunks blood vessel wall.In this step,, and there is quantitative relationship in the eigenvalue that the shearing wave calculated is propagated along the large artery trunks blood vessel wall between the mechanical attribute value (comprising Young's modulus of elasticity, the coefficient of rigidity, viscosity etc.) of large artery trunks blood vessel wall.These quantitative relationships include but not limited to: by the mechanical model along elastic linear or elastic tubular structure-borne based on Lamb wave, the perhaps mechanical model along the elastic tubular structure-borne based on pressure wave, or quantitative relationship formula or the numerical computation method based on above-mentioned two kinds of models couplings or improved other mechanical models, derived.By above-mentioned quantitative relationship, can go out according to the eigenvalue calculation of shearing wave the transient state elastic modelling quantity of large artery trunks blood vessel wall.These transient state elastic modelling quantity are along with heartbeat real-time change in cardiac cycle, and are recorded in real time by this method.

Step S150: according to described echo-signal, obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections.In this step, at first obtain the change in displacement waveform of large artery trunks blood vessel wall based on the echo position algorithm for estimating according to echo-signal, then according to the displacement waveform of large artery trunks blood vessel wall, obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections.Please refer to Fig. 2 and Fig. 3, the long-pending continuous variation waveform of large artery trunks blood vessel diameter or large artery trunks vessel cross-sections is also along with heartbeat real-time change in cardiac cycle, and recorded in real time by this method.And, in this step of change in displacement waveform that obtains the large artery trunks blood vessel wall based on the echo position algorithm for estimating according to echo-signal, the echo position algorithm for estimating can be normalized crosscorrelation Time Delay Estimation Method, absolute difference summation Time Delay Estimation Method, normalized covariance Time Delay Estimation Method, non-normalized cross-correlation Time Delay Estimation Method, difference of two squares summation Time Delay Estimation Method, mixed signs cross-correlation Time Delay Estimation Method, polarity coincidence Time Delay Estimation Method or Meyr-Spies Time Delay Estimation Method.Its formula apportion is as follows:

The normalized crosscorrelation Time Delay Estimation Method:

R nc ( τ ) = ∫ - T / 2 T / 2 ( s r ( t ) s d ( t + τ ) ) dt ∫ - T / 2 T / 2 ( s r ( t ) ) 2 dt ∫ - T / 2 T / 2 ( s d ( t + τ ) ) 2 dt ;

Absolute difference summation Time Delay Estimation Method:

R SAD ( τ ) = ∫ - T / 2 T / 2 | s r ( t ) - s d ( t + τ ) | dt ;

The normalized covariance Time Delay Estimation Method:

R NCov ( τ ) = ∫ - T / 2 T / 2 ( s r ( t ) - s r ‾ ) ( s d ( t + τ ) - s d ‾ ( τ ) ) dt ∫ - T / 2 T / 2 ( s r ( t ) - s r ‾ ) 2 dt ∫ - T / 2 T / 2 ( s d ( t + τ ) - s d ‾ ( τ ) ) 2 dt ;

Wherein:

s r ‾ = ( 1 T ) ∫ - T / 2 T / 2 s r ( t ) dt ;

s d ‾ ( τ ) = ( 1 T ) ∫ - T / 2 T / 2 s r ( t + τ ) dt ;

Non-normalized cross-correlation Time Delay Estimation Method:

R NNC ( τ ) = ∫ - T / 2 T / 2 s r ( t ) s d ( t + τ ) dt ;

Difference of two squares summation Time Delay Estimation Method:

R SSD ( τ ) = ∫ - T / 2 T / 2 ( s r ( t ) - s d ( t + τ ) ) 2 dt ;

Mixed signs cross-correlation Time Delay Estimation Method:

R HSC ( τ ) = ∫ - T / 2 T / 2 s r ( t ) sign ( s d ( t + τ ) ) dt ;

Wherein:

( x ) = 1 x > 0 - 1 x < 0 0 x = 0 ;

Polarity overlaps Time Delay Estimation Method:

R PCC ( &tau; ) = &Integral; - T / 2 T / 2 sign ( s r ( t ) ) sign ( s d ( t + &tau; ) ) dt ;

The Meyr-Spies Time Delay Estimation Method:

R MSM ( &tau; ) = &Integral; - T / 2 T / 2 ( - s r ( t ) + s t ( t - 2 ) ) ( s d ( ( t - 1 ) + &tau; ) ) dt .

Step S160: the continuous variation waveform that goes out the large artery trunks internal blood pressure according to the transient state elastic modelling quantity of described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or the long-pending continuous variation waveshape of large artery trunks vessel cross-sections.And

Step S170: obtain auterial diastole and press, and the continuous variation waveform based on the large artery trunks internal blood pressure and auterial diastole are pressed and calculated large artery trunks continuous blood pressure waveform.In step S160 and step S170, concerning the large artery trunks blood vessel wall, the variation of large artery trunks internal blood vessel blood pressure is stress Δ P, and the variation of large artery trunks diameter or large artery trunks cross-sectional area is strain Δ D or Δ S, and what connect " stress-strain " relation is the transient state elastic modulus E of blood vessel wall.Following relation is arranged:

ΔP∝ΔD*E??????or?????ΔP∝ΔS*E;

Because the numerical value that auterial diastole is pressed in the different tremulous pulsies of whole body is basic identical, and it is also very little over time, therefore can compress into row to the auterial diastole of femoral artery or brachial artery with traditional blood pressure measuring method and measure, and using this as reference value.According to above-mentioned " stress-strain " relation, by artery diameter or tremulous pulse cross-sectional area, transient state elastic modelling quantity and benchmark pressure value, extrapolate the continuous blood pressure waveform and the transient state blood pressure values that constantly change in cardiac cycle again.Like this, above-mentioned large artery trunks noinvasive continuous BP measurement method just can be applied to the measurement of the aortic pressures such as carotid artery, has prior clinical value.

In addition, present embodiment also provides a kind of large artery trunks noinvasive continuous blood pressure measurer 400.Please refer to Fig. 4, large artery trunks noinvasive continuous blood pressure measurer comprises ultrasonic output/input module 410, ultrasound emission/receiver module 420, control/communication module 430 and signal processing module 440.Ultrasonic output/input module 410 is connected to each other with ultrasound emission/receiver module 420.Ultrasound emission/receiver module 420 is connected to each other with control/communication module 430.Control/communication module 430 is connected to signal processing module 440.

Wherein, ultrasonic output/input module 410 is for launching ultrasonic beam and receiving echo-signal to large artery trunks blood vessel to be measured region.Ultrasound emission/receiver module 420 is for generation of ultrasonic beam and receive the echo-signal received by ultrasonic output/input module 410.Control/communication module 430 is for controlling ultrasound emission/receiver module 420 and signal processing module 440.And signal processing module 440 is for the treatment of echo-signal and calculate large artery trunks continuous blood pressure waveform.

In conjunction with aforementioned large artery trunks noinvasive continuous BP measurement method, the ultrasonic output/input module 410 of the large artery trunks noinvasive continuous blood pressure measurer 400 of present embodiment can be used for launching the first ultrasonic beam to large artery trunks blood vessel to be measured region, makes the soft tissue generation of vibration shearing wave of large artery trunks blood vessel to be measured region; Also can be used for launching the second ultrasonic beam to large artery trunks blood vessel to be measured region, and collect the echo-signal that the second ultrasonic beam causes.The echo-signal that ultrasound emission/receiver module 420 receives ultrasonic output/input module 410 transfers to signal processing module 440 by control/communication module 430.The soft tissue that signal processing module 440 just can extract by large artery trunks blood vessel to be measured region from echo-signal vibrates the shearing wave formed, and calculates the eigenvalue that shearing wave is propagated along the large artery trunks blood vessel wall; The eigenvalue calculation that signal processing module 440 is propagated along the large artery trunks blood vessel wall according to shearing wave again goes out the transient state elastic modelling quantity of large artery trunks blood vessel wall; Synchronous signal processing module 440 obtains large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to echo-signal; Then signal processing module 440 goes out the continuous variation waveform of large artery trunks internal blood pressure again according to the transient state elastic modelling quantity of large artery trunks blood vessel wall and large artery trunks blood vessel diameter or the long-pending continuous variation waveshape of large artery trunks vessel cross-sections; Continuous variation waveform and the auterial diastole pressure of last signal processing module 440 based on the large artery trunks internal blood pressure calculates large artery trunks continuous blood pressure waveform.Wherein, auterial diastole is pressed to compress into to go to the auterial diastole of femoral artery or brachial artery with traditional blood pressure measuring method and is measured.

For reflected signal processing module 440 results intuitively, the large artery trunks noinvasive continuous blood pressure measurer 400 of present embodiment also comprises human-computer interaction interface module 450.Human-computer interaction interface module 450 is connected to each other with control/communication module 430, and human-computer interaction interface module 450 is connected in signal processing module 440.Like this, human-computer interaction interface module 450 just can receive outside input instruction, can also export by signal processing module 440 simultaneously and process large artery trunks blood vessel diameter that echo-signals obtain or the information such as the long-pending continuous variation waveform of large artery trunks vessel cross-sections, large artery trunks continuous blood pressure oscillogram.

In above-mentioned large artery trunks noinvasive continuous blood pressure measurer 400, ultrasonic output/input module 410 is specifically as follows linear array or the protruding battle array ultrasonic probe of many array elements.Please in conjunction with Fig. 5, before using large artery trunks noinvasive continuous blood pressure measurer 400 measurement aortic pressures, need to be adjusted the linear array of many array elements or protruding battle array ultrasonic probe, make the linear array of many array elements or protruding battle array ultrasonic probe perpendicular or parallel in the large artery trunks vessel axis to.During measurement, imaging surface both can be perpendicular to arteries axially (cross section imaging), can be also to be parallel to arteries axially (vertically imaging).During the cross section imaging, suitable position is that the profile of working as cross section approaches orbicular position.During vertical imaging, suitable position is that the front and back blood vessel wall of tremulous pulse is rendered as two positions of parallel line shaped clearly.Control/communication module 430, signal processing module 440 and human-computer interaction interface module 450 can be integrated in the hardware handles platform, and the hardware handles platform can be computer, single-chip microcomputer, FPGA(Field Programmable Gate Array, field programmable gate array), DSP(Digital Signal Processor, digital signal processor) chip or other can be used for realizing the various hardware handles platforms such as the chip of above-mentioned functions module or complete machine.In addition, also be connected with mould/number conversion module between hardware handles platform and ultrasound emission/receiver module 420.Mould/number conversion module is converted to digital signal and transfers to the hardware handles platform for the echo-signal that ultrasound emission/receiver module is received.

Above-mentioned large artery trunks noinvasive continuous blood pressure measurer 400 is used large artery trunks noinvasive continuous BP measurement method to can be applicable to the measurement of the aortic pressures such as carotid artery, has important clinical use value.

The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (12)

1. a large artery trunks noinvasive continuous BP measurement method, comprise the steps:
Launch the first ultrasonic beam to large artery trunks blood vessel to be measured region, make the soft tissue generation of vibration shearing wave of large artery trunks blood vessel to be measured region;
Launch the second ultrasonic beam to large artery trunks blood vessel to be measured region, and collect the echo-signal that the second ultrasonic beam causes;
Obtain described shearing wave, and calculate the eigenvalue that described shearing wave is propagated along the large artery trunks blood vessel wall;
The eigenvalue calculation of propagating along the large artery trunks blood vessel wall according to described shearing wave goes out the transient state elastic modelling quantity of large artery trunks blood vessel wall;
Obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to described echo-signal;
Go out the continuous variation waveform of large artery trunks internal blood pressure according to the transient state elastic modelling quantity of described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or the long-pending continuous variation waveshape of large artery trunks vessel cross-sections; And
Obtain auterial diastole and press, and the continuous variation waveform based on the large artery trunks internal blood pressure and auterial diastole are pressed and calculated large artery trunks continuous blood pressure waveform.
2. large artery trunks noinvasive continuous BP measurement method according to claim 1, it is characterized in that, describedly extract the shearing wave formed by the vibration of the soft tissue of large artery trunks blood vessel to be measured region from described echo-signal, and calculate described shearing wave and comprise along the step of the eigenvalue of large artery trunks blood vessel wall propagation:
Calculate shearing velocity of wave propagation and the shearing wave amplitude attenuation curve with propagation distance.
3. large artery trunks noinvasive continuous BP measurement method according to claim 1, is characterized in that, the described step that obtains the long-pending continuous variation waveform of large artery trunks blood vessel diameter or large artery trunks vessel cross-sections according to described echo-signal comprises:
Obtain the change in displacement waveform of large artery trunks blood vessel wall according to echo-signal based on the echo position algorithm for estimating; And
Obtain large artery trunks blood vessel diameter or the long-pending continuous variation waveform of large artery trunks vessel cross-sections according to the displacement waveform of large artery trunks blood vessel wall.
4. large artery trunks noinvasive continuous BP measurement method according to claim 3, it is characterized in that, in the step of the described change in displacement waveform that obtains the large artery trunks blood vessel wall based on the echo position algorithm for estimating according to echo-signal, described echo position algorithm for estimating comprises the normalized crosscorrelation Time Delay Estimation Method, absolute difference summation Time Delay Estimation Method, the normalized covariance Time Delay Estimation Method, non-normalized cross-correlation Time Delay Estimation Method, difference of two squares summation Time Delay Estimation Method, mixed signs cross-correlation Time Delay Estimation Method, polarity overlaps Time Delay Estimation Method and Meyr-Spies Time Delay Estimation Method.
5. large artery trunks noinvasive continuous BP measurement method according to claim 1, it is characterized in that, the step that the long-pending continuous variation waveshape of the described elastic modelling quantity of the transient state according to described large artery trunks blood vessel wall and large artery trunks blood vessel diameter or large artery trunks vessel cross-sections goes out the continuous variation waveform of large artery trunks internal blood pressure realizes by following formula:
ΔP∝ΔD*E????or????ΔP∝ΔS*E;
Wherein, Δ P means the variable quantity of large artery trunks internal blood pressure, and Δ D means the variable quantity of large artery trunks blood vessel diameter, and Δ S means the variable quantity that the large artery trunks vessel cross-sections is long-pending, and E means the transient state elastic modelling quantity of large artery trunks blood vessel wall.
6. large artery trunks noinvasive continuous BP measurement method according to claim 1, is characterized in that, described launch the step of the first ultrasonic beam to large artery trunks blood vessel to be measured region before, also comprise:
Adjust ultrasonic output/input module, make ultrasonic output/input module aim at large artery trunks blood vessel region.
7. a large artery trunks noinvasive continuous blood pressure measurer, it is characterized in that, comprise ultrasonic output/input module, ultrasound emission/receiver module, control/communication module and signal processing module, described ultrasonic output/input module and ultrasound emission/receiver module are connected to each other, described ultrasound emission/receiver module and control/communication module are connected to each other, and described control/communication module is connected to signal processing module;
Described ultrasonic output/input module is for launching ultrasonic beam and receiving echo-signal to large artery trunks blood vessel to be measured region, described ultrasound emission/receiver module is for generation of ultrasonic beam and receive the echo-signal received by described ultrasonic output/input module, described control/communication module is for controlling ultrasound emission/receiver module and signal processing module, and described signal processing module is for the treatment of echo-signal and calculate large artery trunks continuous blood pressure waveform.
8. large artery trunks noinvasive continuous blood pressure measurer according to claim 7, it is characterized in that, described large artery trunks noinvasive continuous blood pressure measurer also comprises the human-computer interaction interface module, described human-computer interaction interface module and control/communication module are connected to each other, and described human-computer interaction interface module is connected in signal processing module, for receiving outside input instruction, also for exporting large artery trunks continuous blood pressure oscillogram.
9. large artery trunks noinvasive continuous blood pressure measurer according to claim 7, is characterized in that, the linear array that described ultrasonic output/input module is many array elements or protruding battle array ultrasonic probe.
10. large artery trunks noinvasive continuous blood pressure measurer according to claim 8, it is characterized in that, described control/communication module, signal processing module and human-computer interaction interface module integration are in the hardware handles platform, and described hardware handles platform is computer, single-chip microcomputer, FPGA or dsp chip.
11. large artery trunks noinvasive continuous blood pressure measurer according to claim 10, it is characterized in that, also be connected with mould/number conversion module between described hardware handles platform and ultrasound emission/receiver module, the echo-signal that described mould/the number conversion module receives ultrasound emission/receiver module is converted to digital signal and transfers to the hardware handles platform.
12. large artery trunks noinvasive continuous blood pressure measurer according to claim 9, is characterized in that, the linear array of described many array elements or protruding battle array ultrasonic probe perpendicular or parallel in the large artery trunks vessel axis to.
CN201310416484.3A 2013-09-12 2013-09-12 Large artery trunks noinvasive continuous blood pressure measurer CN103445808B (en)

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