CN103431864A - Superparamagnetic ferroferric oxide nanoparticle imaging system and method - Google Patents
Superparamagnetic ferroferric oxide nanoparticle imaging system and method Download PDFInfo
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- CN103431864A CN103431864A CN2013104046419A CN201310404641A CN103431864A CN 103431864 A CN103431864 A CN 103431864A CN 2013104046419 A CN2013104046419 A CN 2013104046419A CN 201310404641 A CN201310404641 A CN 201310404641A CN 103431864 A CN103431864 A CN 103431864A
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Abstract
The invention discloses a superparamagnetic ferroferric oxide nanoparticle imaging system. The superparamagnetic ferroferric oxide nanoparticle imaging system comprises a signal source unit, a scanning unit, a processing unit and a calculation unit, wherein the signal source unit is used for providing a current signal and a voltage signal; the scanning unit is connected with the signal source unit, and is used for scanning superparamagnetic ferroferric oxide nanoparticles in a target object by virtue of an oscillating magnetic field, so that an oscillating current signal is converted to a nonlinear response signal; the processing unit is connected with the scanning unit, and is used for receiving the nonlinear response signal of the scanning unit, performing filter and amplification processing on the received nonlinear response signal, and performing digital signal acquisition on an analogue signal; the calculation unit is connected with the processing unit, and is used for performing subsequent processing on the digital signal, so as to obtain a distribution diagram of the superparamagnetic ferroferric oxide nanoparticles in a body of the target object.
Description
Technical field
The present invention relates to a kind of SPIO nanoparticle imaging system and formation method.
Background technology
In the past few decades, tomography has produced revolutionary impact to medical diagnosis, and develops into the indispensable instrument of some disease of diagnosis.In the century in the past, people have proposed various methods.Most important have a computed tomography (computed tomography (CT)), nuclear magnetic resonance (magnetic resonance imaging (MRI)), positron emission tomography (positron emission tomography (PET)) and single photon emission computed tomography (single photon emission computed tomography (SPECT)).This several method has all been applied different physical effects directly or indirectly.Generally speaking, these methods can be divided into two large classes.The first kind is to measure certain parameter, and this parameter be directly and the bodily tissue of the imaging moiety of wanting be associated, we can be referred to as the nature imaging, for example CT and MRI, the CT measurement be the decay of X-ray, and the MRI measurement is the density of proton.Equations of The Second Kind is applied tracer in vivo, and the spatial distribution of then tracer in body being collected is carried out imaging, for example PET and SPECT, and they carry out imaging to the distribution of radioactive indicator.It should be noted that in CT and MRI and also use tracer material, but be mainly in order to improve contrast, rather than directly tracer material is carried out to imaging.
But traditional imaging mode has their drawback, and image taking speed is slow, can't complete realtime imaging is the shortcoming of most of imaging system.A kind of new imaging mode produced based on different physical effects has been proposed thus, the magnetic nanometer particle imaging technique.
Magnetic nanometer particle imaging (MPI) technology is a kind of new medical imaging mode, and it carries out imaging by detecting extra small paramagnetic ferriferrous oxide (USPIO) nanoparticle, is intended to realize high-resolution and highly sensitive photo-quality imaging mode.The magnetic nanometer particle imaging technique takes full advantage of the nonlinear response of super-paramagnetism nano microgranule in oscillating magnetic field, magnetic nanometer particles is placed in to strong static magnetic field gradient environment, produce oscillating magnetic field by alternating current, make magnetic nanometer particle produce nonlinear response, by computational analysis, thereby generate superparamagnetic nanoparticle scattergram, be embodied as picture.
Magnetic nanometer particle imaging (MPI) is at first to be proposed in calendar year 2001 by the Philip academy who is located at hamburger, researcher Bernhard Gleich delivers this idea with the form of patent, referring to Gleich, B.:Verfahren zur Ermittlung der r ¨ aumlichen Verteilung magnetischer Partikel.German Patent No.DE-10151778-A1,2001.Then in 2005, Bernhard Gleich and the Philip academy Jurgen Weizenecker that works together has invented the still image scanning of first magnetic nanometer particle imaging (MPI), realized two-dimensional imaging, referring to Gleich, B., Weizenecker, J.: " Tomographic imaging using the nonlinear response of magnetic particles " .Nature435 (7046), 1214 – 1217 (2005).What yet this system adopted is the mechanical scanning mode, and its scanning speed is too slow, can only obtain still image, do not reach realtime imaging far away, and it has adopted coil to produce and has selected field, has greatly increased the heat dissipation capacity of system, makes the working time of system greatly reduce.This invention has adopted the mode of electron scanning, makes scanning speed greatly increase, and has adopted neodymium iron boron strong magnet (NdFeB) to produce selection, thereby has reduced the heat dissipation capacity of system, has increased the working time of system.
Summary of the invention
Main purpose of the present invention is to design a kind of SPIO nanoparticle imaging system, comprising:
The signal source unit, described signal source unit provides current signal and voltage signal;
Scanning element, described scanning element is connected with described signal source unit, and described scanning element by the vibration magnetic field scan the SPIO nanoparticle in target object, thereby the current signal of vibration is transformed into to the nonlinear response signal;
Processing unit, described processing unit is connected with described scanning element, and described processing unit receives the nonlinear response signal of described scanning element, and described processing unit carries out filtering and processing and amplifying to the nonlinear response signal of receiving, and analogue signal is carried out to digital signal acquiring;
Computing unit, it is connected with described processing unit, in order to described digital signal is carried out to subsequent treatment, obtains the scattergram of SPIO nanoparticle in the target object body.
On the basis of technique scheme, described scanning element comprises excitation coil, the SPIO nanoparticle, at least two neodymium iron boron strong magnets, receiving coil, described receiving coil is sheathed in described excitation coil, and described SPIO nanoparticle is positioned at described receiving coil, and described two neodymium iron boron strong magnets are positioned at the two ends of described excitation coil.
On the basis of technique scheme, described neodymium iron boron strong magnet produces saturated selection, and described saturated selection field intensity scope is > 5mT, gradient is 2.0T/m～6.0T/m, exciting field intensity is > 20mT.
On the basis of technique scheme, a described saturated selection zone line forms without the magnetic field point.
On the basis of technique scheme, described processing unit comprises band elimination filter, power amplifier, high pass filter and digital to analog converter.
On the basis of technique scheme, described computing unit is single-chip microcomputer and computer.
The present invention also provides a kind of formation method that uses SPIO nanoparticle imaging system, comprises the following steps:
S1 two neodymium iron boron strong magnets produce saturated selection;
S2 signal source unit passes into alternating current in excitation coil, makes excitation coil produce oscillating magnetic field;
S3 is placed in the SPIO nanoparticle in a saturated selection scope, the SPIO nanoparticle without magnetic field point through out-of-date generation nonlinear response signal;
The S4 receiving coil receives above-mentioned nonlinear response signal, and it is transferred to processing unit;
The S5 processing unit, through after the filtering to nonlinear properties and amplifying, is transferred to computing unit by signal;
The S6 computing unit, by computational analysis, obtains the concentration profile of SPIO nanoparticle in target area.
With respect to prior art, the present invention has following advantage:
(1) there is higher spatial resolution and temporal resolution.Be different from the indirect imaging mode of other imagings (as NMR (Nuclear Magnetic Resonance)-imaging, by measure the existence of magnetic field and then detecting magnetic particle with the relaxation time), SPIO nanoparticle imaging system is that the ferromagnetic characteristic to the SPIO nanoparticle carries out direct imaging, so image taking speed and resolution want high.These characteristics are extremely important to realtime imaging medically.
(2) imaging mode is flexible.SPIO nanoparticle imaging system can be adjusted to the quality of picture by selecting suitably acquisition parameter.For example can improve sensitivity by reducing temporal resolution.
(3) without background noise.Because human body is nonmagnetic, can not make nonlinear response to the magnetic field of vibration, therefore can not produce and disturb the nonlinear response of tracer SPIO nanoparticle, also, just without the generation of background noise, can effectively improve signal to noise ratio.
(4) workable.Simple to operate, flexible, convenient.This system bulk is less, and in when diagnosis, operator and other staff can be operated under the help of display, makes the operator of each side can tacit cooperation and safety.Thereby operate flexibly, conveniently, be easy to grasp.
(5) safe.Due to this imaging system employing is that various static state and oscillating magnetic field are measured, so it does not have ionizing radiation fully, the tracer (SPIO nanoparticle) simultaneously used due to this system can not produce any harm to human body, so its safety will be higher than other imaging mode.
The accompanying drawing explanation
Fig. 1 is the SPIO nanoparticle imaging system that the embodiment of the present invention provides
The composition framework schematic diagram of system;
Fig. 2 is the SPIO nanoparticle imaging system that the embodiment of the present invention provides
Scanning element structural principle schematic diagram in system;
Fig. 3 is the flow chart of the SPIO nanoparticle imaging system formation method that provides of the embodiment of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, embodiments of the invention are elaborated.
Please refer to Fig. 1 and Fig. 2, Figure 1 shows that the composition framework schematic diagram of the SPIO nanoparticle imaging system that the embodiment of the present invention provides.Comprise signal source unit 1, scanning element 2, processing unit 3, computing unit 4.Signal source unit 1 provides electric current and voltage signal source for scanning element 2, then converts thereof into nonlinear properties by scanning element 2, after the filtering and processing and amplifying of the treated unit 3 of described nonlinear properties, by computing unit 4, carries out follow-up image reconstruction and demonstration.
Figure 2 shows that a kind of composition structure of scanning element 2 in the SPIO nanoparticle imaging system that the embodiment of the present invention provides, comprise excitation coil 2a, SPIO nanoparticle 2b, neodymium iron boron strong magnet 2c, receiving coil 2d.Scanning element 2 comprises excitation coil 2a, SPIO nanoparticle 2b, at least two neodymium iron boron strong magnet 2c, receiving coil 2d, described receiving coil 2d is sheathed in described excitation coil 2a, SPIO nanoparticle 2b is positioned at described receiving coil, and described two neodymium iron boron strong magnet 2c are positioned at the two ends of described excitation coil 2a.
The using method of the SPIO nanoparticle 2b imaging system provided according to the embodiment of the present invention is described below with reference to Fig. 3, specific as follows:
Step S1, used neodymium iron boron strong magnet 2c to produce and select field
Particularly, make two neodymium iron boron strong magnet 2c homopolarities relative, produce between neodymium iron boron strong magnet 2c and select field, middle is called the FFP point without the magnetic field point, SPIO nanoparticle 2b is placed in and selects, in a scope, to make except the SPIO nanoparticle 2b without magnetic field point FFP point in the magnetic saturation state;
Step S2, signal source unit 1 sends alternating current, generates oscillating magnetic field
Particularly, use signal source unit 1 to pass into alternating current in excitation coil 2a, make it produce rectilinear oscillation magnetic field, an oscillating magnetic field and selection stack mutually, thus without magnetic field point FFP, the cycle moves within the specific limits in promotion;
Step S3, receive nonlinear properties
Particularly, in the zone without magnetic field point FFP process, SPIO nanoparticle 2b becomes under the saturation of magnetic field under unsaturated state can produce nonlinear response, uses receiving coil 2d to receive this nonlinear response;
Step S4, carry out denoising and amplification to signal
Particularly, the nonlinear response signal of the SPIO nanoparticle 2b collected based on step S2 and S3,3 pairs of target signal filter noises of signal processing unit and fundamental wave, carry out processing and amplifying to signal afterwards, and signal sampled;
Step S5, rebuild image
Particularly, the sampled signal obtained based on step S4, computing unit 4 is rebuild image by algorithm for reconstructing, thereby obtains the concentration profile of SPIO nanoparticle 2b in selecting the territory, place.
Those skilled in the art will benefit from the instruction presented in aforementioned specification and relevant drawings and expect multiple remodeling of the present invention as herein described and other embodiment.Therefore, should be appreciated that and the invention is not restricted to disclosed specific embodiment, and should be appreciated that, the present invention is intended to modification and other embodiment are included in the scope be defined by the following claims.Although this paper has adopted concrete term, just from the angle of describing, use them, and also unrestricted.
Claims (7)
1. a SPIO nanoparticle imaging system, is characterized in that, comprising:
The signal source unit, described signal source unit provides current signal and voltage signal;
Scanning element, described scanning element is connected with described signal source unit, and described scanning element by the vibration magnetic field scan the SPIO nanoparticle in target object, thereby the current signal of vibration is transformed into to the nonlinear response signal;
Processing unit, described processing unit is connected with described scanning element, and described processing unit receives the nonlinear response signal of described scanning element, and described processing unit carries out filtering and processing and amplifying to the nonlinear response signal of receiving, and analogue signal is carried out to digital signal acquiring;
Computing unit, it is connected with described processing unit, in order to described digital signal is carried out to subsequent treatment, obtains the scattergram of SPIO nanoparticle in the target object body.
2. a kind of SPIO nanoparticle imaging system as claimed in claim 1, it is characterized in that: described scanning element comprises excitation coil, the SPIO nanoparticle, at least two neodymium iron boron strong magnets, receiving coil, described receiving coil is sheathed in described excitation coil, and described SPIO nanoparticle is positioned at described receiving coil, and described two neodymium iron boron strong magnets are positioned at the two ends of described excitation coil.
3. a kind of SPIO nanoparticle imaging system as claimed in claim 2, it is characterized in that: described neodymium iron boron strong magnet produces saturated selection, described saturated selection field intensity scope is > 5mT, gradient is 2.0T/m～6.0T/m, exciting field intensity is > 20mT.
4. a kind of SPIO nanoparticle imaging system as claimed in claim 2 is characterized in that: a described saturated selection zone line forms without the magnetic field point.
5. a kind of SPIO nanoparticle imaging system as claimed in claim 1, it is characterized in that: described processing unit comprises band elimination filter, power amplifier, high pass filter and digital to analog converter.
6. a kind of SPIO nanoparticle imaging system as claimed in claim 1, it is characterized in that: described computing unit is single-chip microcomputer and computer.
7. the formation method of the described SPIO nanoparticle of a right to use requirement 2-5 any one imaging system, is characterized in that, comprises the following steps:
S1 two neodymium iron boron strong magnets produce saturated selection;
S2 signal source unit passes into alternating current in excitation coil, makes excitation coil produce oscillating magnetic field;
S3 is placed in the SPIO nanoparticle in a saturated selection scope, the SPIO nanoparticle without magnetic field point through out-of-date generation nonlinear response signal;
The S4 receiving coil receives above-mentioned nonlinear response signal, and it is transferred to processing unit;
The S5 processing unit, through after the filtering to nonlinear properties and amplifying, is transferred to computing unit by signal;
The S6 computing unit, by computational analysis, obtains the concentration profile of SPIO nanoparticle in target area.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022120985A1 (en) * | 2020-12-10 | 2022-06-16 | 中国科学院深圳先进技术研究院 | Low cost magnetic nanoparticle imaging system, and method |
| WO2023042265A1 (en) * | 2021-09-14 | 2023-03-23 | 三菱電機株式会社 | Magnetic micro-particle imaging device |
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| CN102982939A (en) * | 2012-11-19 | 2013-03-20 | 宁波科星材料科技有限公司 | Neodymium-iron-boron permanent magnet material and preparation method thereof |
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| CN101031239A (en) * | 2004-09-28 | 2007-09-05 | 皇家飞利浦电子股份有限公司 | Method of determining a spatial distribution of magnetic particles |
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| WO2022120985A1 (en) * | 2020-12-10 | 2022-06-16 | 中国科学院深圳先进技术研究院 | Low cost magnetic nanoparticle imaging system, and method |
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