CN103417744B - Medicine curing pediatric hernia and preparation method thereof - Google Patents
Medicine curing pediatric hernia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine curing a pediatric hernia and a preparation method thereof. The medicine curing the pediatric hernia is mainly composed of common dayflower herbs, szechwan chinaberry fruits, hawthorn seeds, tangerine seeds, plantain herbs, common fenugreek seed and other medicines according to a certain weight ratio. The medicine curing the pediatric hernia has the functions of dispelling melancholy, promoting Qi, dispelling cold and stopping pain, is used for curing the pediatric hernia, and is high in cure rate.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of infantile hernia and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Infantile hernia and children inguinal hernia gas, be commonly called as hernia, at embryonic stage, there is one " peritoneum processus vaginalis " at groin place, testis can be helped to fall into the fixing of scrotum or round ligament of uterus, after some child birth, this processus vaginalis is closed not exclusively, cause Intraabdominal small intestinal, nethike embrane, ovary, fallopian tube etc. enter this processus vaginalis, namely become hernia, if only there is peritoneal fluid to enter in scrotum, be edema of scrotum.The general incidence rate of hernia is 1-4%, and boy student is 10 times of schoolgirl, and premature infant is then higher, and may betide both sides.At present, because Western medicine effectively cannot treat infantile hernia, and easily recur, and have a lot of side effect, therefore, there is very large demand to the Chinese medicine of effectively treating infantile hernia in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment infantile hernia, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating infantile hernia.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Commelinae, Fructus Toosendan, Semen Crataegi, Semen Citri Reticulatae, Herba Plantaginis, Semen Trigonellae, Lignum Aquilariae Resinatum, sulfur, Carnis caprae seu ovis, Carnis Canitis, the Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis, the Radix Linderae, Cortex Cinnamomi, Pericarpium Granati, Fructus Crataegi medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of infantile hernia.Herba Commelinae is wherein selected to be because its nature and flavor are sweet, cold, there is heat clearing away, removing heat from blood, the function of removing toxic substances, harness the river swollen, beriberi, dysuria, treat laryngopharynx swelling and pain, malaria, hematodiarrhoea.Select Fructus Toosendan to be because its nature and flavor are bitter, cold, poisonous, enter liver, stomach, small intestine meridian, have wet down heat, clearing away liver-fire, pain relieving, the function of parasite killing, controls epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.Semen Crataegi is selected to be because it controls food stagnation, the function of hernia.Semen Citri Reticulatae is selected to be that flat, nontoxic, enter liver, kidney channel, regulate the flow of vital energy, the function of pain relieving, controls hernia, painful and swollen testis, acute mastitis, lumbago, colicky pain of bladder because its nature and flavor are bitter.Herba Plantaginis is selected to be that cold, enter liver, spleen two warp, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, jaundice, edema, and hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis because its nature and flavor are sweet, cough, skin ulcer.Semen Trigonellae is selected to be that enter kidney, Liver Channel, have kidney-replenishing, the function of dispelling cold and dampness, controls colic of cold type because the bitter temperature of its nature and flavor, abdomen side of body distension, beriberi, sexual impotence.Select Lignum Aquilariae Resinatum to be because its nature and flavor are worked hard, enter kidney, spleen, stomach warp, have sending down the abnormal ascending QI warming middle-JIAO, the function of warming the kidney improving inspiration by invigorating kidney-QI, control QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.Select sulfur to be because its nature and flavor are sour, temperature, poisonous, return kidney, large intestine channel, external removing toxic substances parasite killing treats skin ulcer, the fiery supporing yang relieving constipation of benefit for oral administration; External scabies, tinea alba, cloudy resistance malignant boil; Take orally for sexual impotence cold foot, dyspnea due to deficiency cold asthma, deficiency and coldness constipation.Select Carnis caprae seu ovis to be that temperature, enters spleen, kidney channel, have QI invigorating tonify deficiency, the function under warming middle-JIAO warms up, control asthenia weakness and emaciation, soreness of the waist and knees because its nature and flavor are sweet, puerperal, cold caused by deficiency, suffered from abdominal pain, colic of cold type, middle empty regurgitation.Select Carnis Canitis to be because its nature and flavor are salty, temperature, enters spleen, stomach, kidney channel, has invigorating the spleen and replenishing QI, the function of warming the kidney to activate YANG, control spleen deficiency of kidney-QI, distension and fullness of the chest and abdomen, tympanites, edema, and waist paint is weak, and algid malaria, loses skin ulcer and do not restrain for a long time.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Morindae Officinalis to be because its property acrid-sweet flavor, temperature, enter liver, kidney channel, have kidney-replenishing, strengthening bone and muscle, the function of wind-damp dispelling, controls sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.Select the Radix Linderae to be that temperature, enters spleen, lung, kidney, urinary bladder channel, have pleasant, dissipating depression of QI, cold expelling, the function of pain relieving, control QI rising in reverse order chest and abdomen swelling and pain because its nature and flavor are pungent, dyspepsia is discontented with, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Pericarpium Granati to be because its nature and flavor are sour and astringent, temperature, poisonous, enter large intestine, kidney channel, have astringing intestine to stop diarrhea, hemostasis, the function of anthelmintic, controls chronic diarrhea, and chronic dysentery is had blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Herba Commelinae 10-15 gram of Fructus Toosendan 8-15 gram of Semen Crataegi 8-15 gram
Semen Citri Reticulatae 10-15 gram of Herba Plantaginis 8-15 gram of Semen Trigonellae 6-10 gram
Lignum Aquilariae Resinatum 3-5 gram of sulfur 1-3 gram of Carnis caprae seu ovis 50-60 gram
Carnis Canitis 50-60 gram of Rhizoma Atractylodis Macrocephalae 6-10 gram of Radix Morindae Officinalis 6-10 gram
Radix Linderae 6-9 gram of Cortex Cinnamomi 10-15 gram of Pericarpium Granati 10-15 gram
Fructus Crataegi 6-10 gram
Preferable amount is
Herba Commelinae 12 grams of Fructus Toosendans 10 grams of Semen Crataegis 10 grams
Semen Citri Reticulatae 12 grams of Herba Plantaginiss 10 grams of Semen Trigonellaes 8 grams
55 grams, Lignum Aquilariae Resinatum 3 grams of sulfurs 3 grams of Carnis caprae seu ovis
Carnis Canitis 55 grams of Rhizoma Atractylodis Macrocephalaes 8 grams of Radix Morindae Officinaliss 8 grams
The Radix Linderae 8 grams of Cortex Cinnamomis 10 grams of Pericarpium Granatis 12 grams
Fructus Crataegi 8 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Commelinae: pick decontamination, cleans, and cuts off, dries;
2, Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;
3, Semen Crataegi: pick clean impurity, dry;
4, Semen Citri Reticulatae: sieve dedust bits, pick clean impurity, clean, dry;
5, Herba Plantaginis: remove most earth, dry;
6, Semen Trigonellae: pick decontamination, washes, and dries;
7, Lignum Aquilariae Resinatum: outwash, is split into fritter, smashs to pieces;
8, sulfur: get crude drug, removing impurity, breaks into fragment;
9, Carnis caprae seu ovis: get new fresh mutton, cleans, stripping and slicing;
10, Carnis Canitis: get fresh Carnis Canitis, cleans, stripping and slicing;
11, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
12, Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;
13, the Radix Linderae: pick decontamination, separately size bar, saturating with blister, changing water according to noting season, preventing smelly, pulling section out in time, sieve dedust bits;
14, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, smash, or scrape off rough bark, infiltrates by warm water, and section, dries;
15, Pericarpium Granati: pick decontamination, removes residual interior flesh and son, and clean, stripping and slicing, dries;
16, Fructus Crataegi: pick clean impurity, sieve enucleation.
Two, prepare
The Herba Commelinae of described weight, Fructus Toosendan, Semen Crataegi, Semen Citri Reticulatae, Herba Plantaginis, Semen Trigonellae, Lignum Aquilariae Resinatum, sulfur, Carnis caprae seu ovis, Carnis Canitis, the Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis, the Radix Linderae, Cortex Cinnamomi, Pericarpium Granati, Fructus Crataegi are decocted with water, add water 8 times amount, soak 180 minutes, decoct boiling 30 minutes with high heat, use slow fire boiling again 30 minutes, filter and get final product, be divided into 3 doses to take decoction medicinal liquid.
Medicine of the present invention has pleasant, dissipating depression of QI, cold expelling, effect of pain relieving, and treatment infantile hernia instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 10, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 150 example for medical treatment.
2, diagnostic criteria
Clinical symptoms
(1) infantile hernia likely can occur after a couple of days, several months or several years after birth.
(2) usually cry and scream child, strenuous exercise, constipation with dry stool time, have the swollen thing of a projection bulk at groin place, extend to scrotum or labial regions sometimes; Can die away when lying low or press with hands.
(3) once hernia block generation incarceration (hernia enclosed mass cannot Hui Na), there will be stomachache, Nausea and vomiting, fever, anorexia or cry and scream, dysphoria.
(4) infantile hernia their early stage, the thing that swells when the flat sleeping peace and quiet of child can disappear; Along with intraabdominal pressure continue increase, swollen thing can drop in scrotum.If at this moment can remove the factor that intra-abdominal pressure increases, and make infant flat sleeping, or the thing that will swell lightly pushes toward direction, abdominal cavity, swollen thing then turns back to abdominal cavity by that passage during testicular descent, and swollen thing disappears, and this situation is called recoverability hernia.
(5) if swollen thing can not return and receive abdominal cavity, just there will be stomachache aggravation, crying and screaming more than, then occur the ileus symptoms such as vomiting, abdominal distention, defecation be not smooth, visible oval swollen body thing in groin or scrotum, quality is hard, touches a tender spot obvious; Incarceration person of long duration skin is red and swollen as seen, receives, likely occur the severe complications such as intestinal tube ischemic necrosis if long-time intestinal tube can not return.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 5 days, is a course for the treatment of, takes two courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, body constitution recovers normal, observes 1 year without recidivist;
Take a turn for the better: symptom is clearly better, and symptom fades away;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy infantile hernia patient 150 example of the present invention, effective 145 examples of result, obvious effective rate is 96.67%, and take a turn for the better 3 examples, and improvement rate is 2%, and invalid 2 examples, total effective rate is 98.67%.
Claims (3)
1. treat a medicine for infantile hernia, it is characterized in that: it is made up of the crude drug in following weight range:
Herba Commelinae 10-15 gram of Fructus Toosendan 8-15 gram of Semen Crataegi 8-15 gram
Semen Citri Reticulatae 10-15 gram of Herba Plantaginis 8-15 gram of Semen Trigonellae 6-10 gram
Lignum Aquilariae Resinatum 3-5 gram of sulfur 1-3 gram of Carnis caprae seu ovis 50-60 gram
Carnis Canitis 50-60 gram of Rhizoma Atractylodis Macrocephalae 6-10 gram of Radix Morindae Officinalis 6-10 gram
Radix Linderae 6-9 gram of Cortex Cinnamomi 10-15 gram of Pericarpium Granati 10-15 gram
Fructus Crataegi 6-10 gram.
2. external used medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Commelinae 12 grams of Fructus Toosendans 10 grams of Semen Crataegis 10 grams
Semen Citri Reticulatae 12 grams of Herba Plantaginiss 10 grams of Semen Trigonellaes 8 grams
55 grams, Lignum Aquilariae Resinatum 3 grams of sulfurs 3 grams of Carnis caprae seu ovis
Carnis Canitis 55 grams of Rhizoma Atractylodis Macrocephalaes 8 grams of Radix Morindae Officinaliss 8 grams
The Radix Linderae 8 grams of Cortex Cinnamomis 10 grams of Pericarpium Granatis 12 grams
Fructus Crataegi 8 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Herba Commelinae: pick decontamination, cleans, and cuts off, dries;
(2) Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;
(3) Semen Crataegi: pick clean impurity, dry;
(4) Semen Citri Reticulatae: sieve dedust bits, pick clean impurity, clean, dry;
(5) Herba Plantaginis: remove most earth, dry;
(6) Semen Trigonellae: pick decontamination, washes, and dries;
(7) Lignum Aquilariae Resinatum: outwash, is split into fritter, smashs to pieces;
(8) sulfur: get crude drug, removing impurity, breaks into fragment;
(9) Carnis caprae seu ovis: get new fresh mutton, cleans, stripping and slicing;
(10) Carnis Canitis: get fresh Carnis Canitis, cleans, stripping and slicing;
(11) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(12) Radix Morindae Officinalis: pick decontamination, after soaking, pumps core while hot, cutting, dry with hot water;
(13) Radix Linderae: pick decontamination, separately size bar, saturating with blister, changing water according to noting season, preventing smelly, pulling section out in time, sieve dedust bits;
(14) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, smash, or scrape off rough bark, infiltrates by warm water, and section, dries;
(15) Pericarpium Granati: pick decontamination, removes residual interior flesh and son, and clean, stripping and slicing, dries;
(16) Fructus Crataegi: pick clean impurity, sieve enucleation;
(2) prepare
The Herba Commelinae of described weight, Fructus Toosendan, Semen Crataegi, Semen Citri Reticulatae, Herba Plantaginis, Semen Trigonellae, Lignum Aquilariae Resinatum, sulfur, Carnis caprae seu ovis, Carnis Canitis, the Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis, the Radix Linderae, Cortex Cinnamomi, Pericarpium Granati, Fructus Crataegi are decocted with water, add water 8 times amount, soak 180 minutes, decoct boiling 30 minutes with high heat, use slow fire boiling again 30 minutes, filter and get final product, be divided into 3 doses to take decoction medicinal liquid.
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