CN103393944A - Traditional Chinese medicine used for treating cough - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition used for treating cough. The traditional Chinese medicine composition comprises following raw materials, by weight: 10 portions of Lilium brownie, 5 portions of fructus forsythia, 9 portions of almond, 15 portions of poria cocos, 3 portions of cassia twig, 4 portions of radix ophiopogonis, 2 portions of adenophora root, 5 portions of pericarpium citri reticulatae, 4 portions of anemarrhena, 2 portions of periostracum cicadae, 3 portions of arborvitae seed, 1 portion of fritillaria thun-bergli, 8 portions of platycodon grandiflorum, 10 portions of matrimony vine, 3 portions of flos farfarae, 8 portions of mint, 3 portions of bletilla striata, 5 portions of honeysuckle flower and 6 portions of Chinese angelica.

Description

The Chinese medicine for the treatment of cough

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of cough.

Background technology

Lung is that one of main syndromes of illness is exactly cough.Throughout history, ancient Chinese medicine doctor has different opinion for cough.Huangdi's Internal Classics proposes the demonstration of " vital organs of the human body all make us coughing, and non-only lung also " ".Jing-Yue Complete Works discuss again " cough one card, surreptitiously be seen in family set forth one's views numerous greatly, neither that it is wanted, cause more the descendant face card do not know institute from, so control rare effect ".Zhang Jingyue will be coughed card by being divided into diseases caused by exogenous pathogenic factor, internal injury two classes.Mention again " cold and summer-heat dampness wind-fire six gas, all make us coughing " in " the interchannel six scripts ".Cough is disease and syndrome, and any age all can fall ill, and winter-spring season is common.The cause of disease of cough has diseases caused by exogenous pathogenic factor, internal injury not, it is the cough that causes that heresy of wind, cold, summer-heat, wet, dry, fiery six climate exopathogens attacked lung, for the exogenous cough, in exopathogen again with wind, cold, heat cough is in the majority, and Chang Yifeng is first number, hold under the arm cold or hold heat under the arm, hold dry criminal's lung under the arm, wind and cold or the coughs such as wind heat, wind-dryness occur; , because lungs virtual loss and other visceral dysfunctions have influence on the cough that lung causes, be the endogenous cough.Normal internal injury, exogenous cough's cross-reference and reciprocal causation clinically.Said as " cough of medical science innermost thoughts and feelings ": " the lung body belongs to gold, and such as Zhong Ran, Zhong Fei kowtows and do not ring, and the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens is from the ring of hitting outward, and labor is wanted feelings will, and diet is processed the also ring of the fire of Bo from inside fire attack ".

Cough is take differential diagnosis in terms of eight principles as guiding principle, and head distinguishes diseases caused by exogenous pathogenic factor and internal injury, and is common with the exogenous cough, take a surname, sends out lung qi as basic principle.Wang Shouchuan is divided into wind and cold and the large pattern of syndrome of wind heat two with children's exogenous cough, and Han new people are divided into wind and cold, wind heat and the large pattern of syndrome of wind-dryness three with it, and wherein the cough due to wind and cold, take expelling wind and cold, lung qi dispersing cough-relieving as method for the treatment of, adds and subtracts with jinfeicao powder; The cough due to pathogenic wind-heat, take dispelling wind and heat pathogens, lung qi dispersing cough-relieving as method for the treatment of, adds and subtracts with SANGJU YIN; The wind-dryness cough, take dispelling wind lung heat clearing, nourishing the lung to arrest cough as method for the treatment of, is added and subtracted with Decoction for Reliving Dryness of the Lung.Zhong Hua etc. distinguish and control the exogenous cough according to children's's body constitution, and it is divided into four types is normal matter youngster, phlegm-damp matter youngster, deficiency of vital energy matter youngster and deficiency of YIN matter youngster, and normal matter youngster is to evacuate exopathogen, lung qi dispersing cough-relieving as method for the treatment of, take Apricot Kernel and Perilla Powder, SANGJU YIN and numb Fructus Pruni Shigao Tang etc. as main formula; Phlegm-damp matter youngster is take the spleen strengthening and damp drying, preventing phlegm from forming and stopping coughing as method for the treatment of, take numb Fructus Pruni ERCHEN TANG as main formula; Deficiency of vital energy matter youngster, take the circumstances into consideration to add with resistance and supplementing qi medicines such as the Rhizoma Atractylodis Macrocephalae, the Radixs Astragali in wind and cold or the basic side of wind heat, or Liujunzi Tang adds Rhizoma Belamcandae, Herba Houttuyniae, Fructus Forsythiae, Radix Platycodonis etc. take invigorating the spleen and benefiting QI as method for the treatment of with dispelling wind and ventilating the lung, preventing phlegm from forming and stopping coughing, assistant.

CN102078558A discloses a kind of pharmaceutical composition for the treatment of cough, and wherein the weight proportion of crude drug is as follows: 30 parts of Ramulus Uncariae Cum Uncis, 40 parts of Concretio Silicea Bambusaes, 10 parts of Radix Platycodoniss; 50 parts of Fructus Amomis, 50 parts of Pericarpium Citri Reticulataes, 10 parts, Poria; 50 parts of Herba Menthaes, 20 parts, Radix Glycyrrhizae, 7 parts of Calculus Boviss.

CN101991802A discloses a kind of Chinese medicine preparation for the treatment of cold cough, it contains 30 parts of Flos Loniceraes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herba Artemisiae Scopariaes, 35 parts of the Radixs Stemonae, 30 parts, Radix Glycyrrhizae, 25 parts of Semen Armeniacae Amarums, 25 parts of Semen Platycladi, 20 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Radix Platycodoniss, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Summary of the invention

The invention provides a kind of Chinese medicine composition that is used for the treatment of cough, wherein the weight proportion of crude drug is as follows:

10 parts of Bulbus Liliies, 5 parts of Fructus Forsythiaes, 9 parts, Semen Armeniacae Amarum, 15 parts, Poria, 3 parts of Ramulus Cinnamomi, 4 parts of Radix Ophiopogonis, 2 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Pericarpium Citri Reticulataes, 4 parts of the Rhizoma Anemarrhenaes, 2 parts of Periostracum Cicadaes, 3 parts of Semen Platycladi, 1 part of Bulbus Fritillariae Uninbracteatae, 8 parts of Radix Platycodoniss, 10 parts of Fructus Lyciis, 3 parts of Flos Farfaraees, 8 parts of Herba Menthaes, 3 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5 parts of Flos Loniceraes, 6 parts of Radix Angelicae Sinensis.

Preparation method, for getting above crude drug, is put into container, adds cold water and covers powder, soaks 15～20 minutes, then adds water and do not have approximately 8 centimetres of powder, decocts.Adopt intense fire to decoct at a simmer, boil rear with slow fire boiling 20～30 minutes; Decoct for the second time the water rear slow fire boiling 15～20 minutes of boiling.Twice decoction extracting juice that removes slag, merge.

The specific embodiment

Embodiment 1

10 parts of Bulbus Liliies, 5 parts of Fructus Forsythiaes, 9 parts, Semen Armeniacae Amarum, 15 parts, Poria, 3 parts of Ramulus Cinnamomi, 4 parts of Radix Ophiopogonis, 2 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Pericarpium Citri Reticulataes, 4 parts of the Rhizoma Anemarrhenaes, 2 parts of Periostracum Cicadaes, 3 parts of Semen Platycladi, 1 part of Bulbus Fritillariae Uninbracteatae, 8 parts of Radix Platycodoniss, 10 parts of Fructus Lyciis, 3 parts of Flos Farfaraees, 8 parts of Herba Menthaes, 3 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5 parts of Flos Loniceraes, 6 parts of Radix Angelicae Sinensis.

Preparation method, for getting above crude drug, is put into container, adds cold water and covers powder, soaks 15～20 minutes, then adds water and do not have approximately 8 centimetres of powder, decocts.Adopt intense fire to decoct at a simmer, boil rear with slow fire boiling 20～30 minutes; Decoct for the second time the water rear slow fire boiling 15～20 minutes of boiling.Twice decoction extracting juice that removes slag, merge.

Reference substance 1

The pharmaceutical composition of the disclosed treatment cough of CN102078558A, wherein the weight proportion of crude drug is as follows: 30 parts of Ramulus Uncariae Cum Uncis, 40 parts of Concretio Silicea Bambusaes, 10 parts of Radix Platycodoniss; 50 parts of Fructus Amomis, 50 parts of Pericarpium Citri Reticulataes, 10 parts, Poria; 50 parts of Herba Menthaes, 20 parts, Radix Glycyrrhizae, 7 parts of Calculus Boviss.

Reference substance 2

The Chinese medicine preparation of the disclosed treatment cold cough of CN101991802A, it contains 30 parts of Flos Loniceraes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herba Artemisiae Scopariaes, 35 parts of the Radixs Stemonae, 30 parts, Radix Glycyrrhizae, 25 parts of Semen Armeniacae Amarums, 25 parts of Semen Platycladi, 20 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Radix Platycodoniss, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Experimental example 2: the antitussive effect that sulfur dioxide smog is caused mouse cough model

The mice of 18-22 g is divided into 5 groups at random, model control group gives the gavage normal saline, tested group gives gavage embodiment 1 and reference substance 1, each 2.0 g/kg of 2 described drug samples, positive controls gives Fructus Chebulae's soup extract 2.0 g/kg, the gavage volume is about 1 ml/100 g, successive administration 5 days.After the last administration 30 minutes, mice is put in airtight glass box, quantitatively spraying into smog that sulfur burning generates induces to cause and coughs, record in mouse cough incubation period and 3 minutes the number of times of coughing, tested group of embodiment 1 of result and the average cough latent period of positive drug control group all extend more than 35 seconds, the number of times of on average coughing obviously reduces, tested group of reference substance 1,2 average cough latent period all extend more than 10 seconds, the number of times of on average coughing is more, show that drug sample of the present invention has obvious antitussive effect, be better than Fructus Chebulae's sweet Fructus Citri tangerinae soup extract and reference substance 1,2.Experimental result is as shown in table 1.

Table 1 drug sample of the present invention to sulfur dioxide smog cause mouse cough antitussive effect (

± S, n=15)

Annotate: compare * with model group P＜0.05, * * P＜0.01

Embodiment 3 clinical therapeutic efficacies:

Criterion of therapeutical effect: curative effect judges whether Main Basis disappears for the cough symptom.Medication 15 days was 1 course for the treatment of.Concrete curative effect is divided following three grades: cure---and the cough symptom all disappears; Taking a turn for the better---the cough symptom obviously alleviates; Invalid---after medication 1 course for the treatment of, the cough symptom has no to disappear.

Effect:, with Drug therapy cough patient of the present invention 44 examples, treat 1 course for the treatment of, wherein cure 42 examples, 2 examples that take a turn for the better, cure rate is 95%, effective percentage is 100%.

Model case:

The Qin, female, 55 years old, peasant.In December, 2010 is medical.Patient's readme, violate cough and had a surplus in existing ten days.The symptom cough is breathed hard, coughs up phlegm sticking yellow, and pharyngalgia, micro evil wind is cold.White and thin fur, red tip of the tongue, floating and rapid pulse.Adopt medicine of the present invention, first take 10 days, symptom is clearly better, and follow-uply takes 5 days, recovery from illness.Visited in 2 months, and had no recurrence.

Claims (1)

1. Chinese medicine composition that is used for the treatment of cough, wherein the weight proportion of crude drug is approximately as follows:

10 parts of Bulbus Liliies, 5 parts of Fructus Forsythiaes, 9 parts, Semen Armeniacae Amarum, 15 parts, Poria, 3 parts of Ramulus Cinnamomi, 4 parts of Radix Ophiopogonis, 2 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Pericarpium Citri Reticulataes, 4 parts of the Rhizoma Anemarrhenaes, 2 parts of Periostracum Cicadaes, 3 parts of Semen Platycladi, 1 part of Bulbus Fritillariae Uninbracteatae, 8 parts of Radix Platycodoniss, 10 parts of Fructus Lyciis, 3 parts of Flos Farfaraees, 8 parts of Herba Menthaes, 3 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5 parts of Flos Loniceraes, 6 parts of Radix Angelicae Sinensis.