CN103393883B - 治疗新生儿黄疸的中药组合物 - Google Patents
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Abstract
本发明提供一种安全、方便的治疗新生儿黄疸的中药组合物。本发明采用以下技术方案：一种治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药6-9克，茵陈9-15克，当参9-15克，车前子6-9克，甘草3-10克，滇白芷6-15g，槭叶止血草20-40g，小金钱草20-40g，马鞭草20-40g，荷莲豆草20-40g，焦山楂6-9克，茜草9-15克，北风草20-40g。
Description
技术领域
本发明涉及一种治疗新生儿黄疸的中药组合物，属于中药领域。
背景技术
新生儿黄疸是新生期常见症状之一，尤其是一周内的新生儿，既可以是生理现象，又可为多种疾病的主要表现。胆红素重度升高或虽然不很高，但同时存在缺氧、酸中毒、感染等高危因素时，可引起胆红素脑病，死亡率高，幸存者多存在远期神经系统后遗症。
临床一般将小儿黄疸分为湿热型、热毒型、瘀滞型、脾湿型四种。湿热型黄疸可见到小儿皮肤黄而鲜明，其色如枯色，伴见发热、烦躁、啼哭、口渴、呕吐、尿黄、便秘等症状；瘀滞型黄疽可见面目及全身发黄，黄色较深且晦暗，并逐渐加重，身体消瘦，饮食减少，大便溏稀，并伴有皮肤出血而见瘀斑瘀点等；脾湿型黄疸的小儿皮肤发黄，日久不易退，其色晦暗，面色无华，体质消瘦，乏力纳少，大便溏软，四肢欠温。
在治疗方面，主要采用以下疗法：
1、光照疗法是一种降低血清未结合胆红素的简单易行方法，通过转变胆红素产生异构体，使胆红素从脂溶性转变为水溶性，不经过肝脏的结合，经胆汁或尿排出体外。此种疗法有一定副作用。
2、交换输血，用于重症母婴血型不合的溶血病。此种方法存在心脏停搏等危险，且有继发感染的可能。
发明内容
本发明目的是提供一种安全、方便的治疗新生儿黄疸的中药组合物。
为了实现上述目的，本发明采用以下技术方案：
一种治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药6-9克，茵陈9-15克，当参9-15克，车前子6-9克，甘草3-10克，滇白芷6-15g，槭叶止血草20-40g，小金钱草20-40g，马鞭草20-40g，荷莲豆草20-40g，焦山楂6-9克，茜草9-15克，北风草20-40g。
进一步地，所述治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药6克，茵陈15克，当参15克，车前子6克，甘草3克，滇白芷9g，槭叶止血草20g，小金钱草20g，马鞭草20g，荷莲豆草20g，焦山楂9克，茜草9克，北风草20g。
服用方法：水煎服，一日一剂，取汁80~100毫升，分3~5次分服。
本发明由纯中药组成，各个中药的功效如下：
山药：味甘，性平。归脾、肺、肾经。补脾养胃，生津益肺，补肾涩精。
茵陈：清热利湿；退黄。主治：黄疸、小便不利、湿疮瘙痒、传染性黄疸型肝炎。等.药理学研究有利胆,保护肝功能,解热，抗炎,降血脂，降压,扩冠等作用。
当参：具有补气、健脾、生津止渴之功，兼能养血。
车前子：利水渗湿，主治：主小便不利、淋浊带下、水肿胀满、暑湿泻痢、目赤障翳、痰热咳喘。
甘草：味甘，性平，无毒。治五脏六腑寒热邪气，坚筋骨，长肌肉，倍气力，解毒，久服轻身延年。生用泻火热，熟用散表寒，去咽痛，除邪热，缓正气，养阴血，补脾胃，润肺。
滇白芷：归肺；胃经。祛风发表；散寒燥湿。主治：风寒感冒；头痛；咳顺；鼻渊；脘腹冷痛；风寒湿痹；寒湿带下；痛经；疮疡肿痛；风疹湿痒。
槭叶止血草：清热凉血，通淋解毒。
小金钱草：性味：苦辛；凉。肺经；肝经。清热；利湿；解毒。主治：黄疸；痢疾；砂淋；白浊；水肿；疔疮肿毒；跌打损伤；毒蛇咬伤。
马鞭草：《中华本草》主治感冒发热；咽喉肿痛；牙龈肿痛；黄疸；痢疾；血瘀经闭；痛经；症瘕；水肿；小便不利；疟疾；痈疮肿毒；跌打损伤。
荷莲豆草：清热解毒，利尿通便，活血消肿，退翳。用于急性肝炎，胃痛，疟疾，翼状胬肉，腹水，便秘；外用治骨折，疮痈，蛇咬伤。
焦山楂：性微温，味酸甘，入脾、胃、肝经，有消食健胃、活血化瘀、收敛止痢之功能。对肉积痰饮、痞满吞酸、泻痢肠风、腰痛疝气、产后儿枕痛、恶露不尽、小儿乳食停滞等，均有疗效。
茜草：有凉血止血、活血化瘀的功效。主治血热咯血、产后瘀阻腹痛、跌打损伤、风湿痹痛等症有凉血止血、活血化瘀的功效。主治血热咯血、产后瘀阻腹痛、跌打损伤、风湿痹痛等症。
北风草: 味苦；微辛；性平。清肺；明目；解毒。主治：肺热咳嗽；胸痛；咽喉肿痛；目赤青盲；乳痈；湿疹；跌打损伤。
中医认为新生儿黄疸病因是：肝胆湿热蕴郁于里，上不得越，下不得泄，熏蒸瘀遏，浸于肺，发于皮，则周身发黄；或由于湿邪内阻，脾阳不振，胆液为湿所困阻，浸淫肌肉，溢于皮肤。故治疗以清热利湿退黄为主，同时注意护脾胃之气，升发胃气。方以党参、山药配合茵陈既是此理；甘草健脾温中；茜草凉血止血；车前子，槭叶止血草，北风草，小金钱草，马鞭草，荷莲豆草均为通利解毒之品。诸药配伍，达到了清热利湿、解毒退黄的功效。
临床疗效总结
一、一般资料：患者65例，其中男婴35例，女婴30例，患儿年龄为10小时—22天。
二、诊断标准：血清胆红素足月儿超过204μmol/L（12mg/dl），早产儿超过255μmol/L（15mg/dl）。
三、服药方法：水煎服本发明的中药组合物，一日一剂，取汁80~100毫升，分3~5次分服。
四、疗效判定标准：
治愈：皮肤黏膜黄疸消退，无重复出现，血清胆红素足月儿为85μmol/L以下；
好转：皮肤黏膜黄疸减轻，血清胆红素足月儿为85μmol/L至204μmol/L（12mg/dl）之间。
无效：皮肤黏膜黄疸程度无明显变化或减轻后又出现，血清胆红素足月儿为204μmol/L以上。
五、治疗效果：
六、典型病例：
1、孙xx,女，20天，全身皮肤呈现黄色，血清胆红素为355，服用本发明药物3剂痊愈，一切正常。
2、李xx,男，60天，患儿出生皮肤发黄，2个月不愈，血清胆红素为299，服用本发明药物2剂痊愈，一切正常，随访半年，不复发，无不良反应。
3、姜xx,32天, 全身皮肤呈现黄色，血清胆红素为482，服用本发明药物5剂痊愈，一周后一切正常，随访二个月，不复发，无不良反应。
本发明的有益效果：
本发明采用纯中药制作简单、副作用小；适于治疗新生儿黄疸。
具体实施方式
下面对本发明做进一步详细说明，以便于本领域人员更好理解本发明。
实施例1
一种治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药9克，茵陈9克，当参12克，车前子9克，甘草10克，滇白芷6g，槭叶止血草30g，小金钱草30g，马鞭草30g，荷莲豆草30g，焦山楂9克，茜草12克，北风草30g。
制备及服用方法：将上述各原料料放入砂锅中，加入水500ml，浸泡1小时后，水煮30分钟，倒出药液；药渣再加入水煮20分钟，倒出药液；两种药液混在一起。一日一剂，取汁80~100毫升，分3~5次分服。
实施例2
一种治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药6克，茵陈15克，当参15克，车前子6克，甘草3克，滇白芷9g，槭叶止血草20g，小金钱草20g，马鞭草20g，荷莲豆草20g，焦山楂9克，茜草9克，北风草20g。
制备及服用方法同实施例1。
实施例3
一种治疗新生儿黄疸的中药组合物，以重量份计，包含以下组分：山药8克，茵陈12克，当参9克，车前子8克，甘草6克，滇白芷15g，槭叶止血草40g，小金钱草40g，马鞭草40g，荷莲豆草40g，焦山楂6克，茜草15克，北风草40g。
制备及服用方法同实施例1。
以上描述了本发明的基本原理及优点。本发明不受上述实例的限制，在不脱离本发明范围的前提下，本领域人员可以根据需要做许多变化和改进。本发明保护范围应由所附的权利要求书及其等效物。
Claims (2)
1.一种治疗新生儿黄疸的中药组合物，其特征是其由下述重量的原料药制成：山药6-9克，茵陈9-15克，当参9-15克，车前子6-9克，甘草3-10克，滇白芷6-15g，槭叶止血草20-40g，小金钱草20-40g，马鞭草20-40g，荷莲豆草20-40g，焦山楂6-9克，茜草9-15克，北风草20-40g。
2.根据权利要求1所述治疗新生儿黄疸的中药组合物，其特征是其由下述重量的原料药制成：山药6克，茵陈15克，当参15克，车前子6克，甘草3克，滇白芷9g，槭叶止血草20g，小金钱草20g，马鞭草20g，荷莲豆草20g，焦山楂9克，茜草9克，北风草20g。
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| 中医中药治疗新生儿黄疸的辩证与分析;张艳平;《中国优生与遗传杂志》;19980430;第6卷(第4期);第107页右栏第3-4段和第6段 * |
| 张艳平.中医中药治疗新生儿黄疸的辩证与分析.《中国优生与遗传杂志》.1998,第6卷(第4期), |
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