CN103393464A - Radiofrequency ablation device - Google Patents
Radiofrequency ablation device Download PDFInfo
- Publication number
- CN103393464A CN103393464A CN2013103401771A CN201310340177A CN103393464A CN 103393464 A CN103393464 A CN 103393464A CN 2013103401771 A CN2013103401771 A CN 2013103401771A CN 201310340177 A CN201310340177 A CN 201310340177A CN 103393464 A CN103393464 A CN 103393464A
- Authority
- CN
- China
- Prior art keywords
- electrode
- ablation device
- renal artery
- radio
- ablation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000007674 radiofrequency ablation Methods 0.000 title claims abstract description 28
- 210000002254 renal artery Anatomy 0.000 claims abstract description 48
- 230000002889 sympathetic effect Effects 0.000 claims abstract description 26
- 210000005036 nerve Anatomy 0.000 claims abstract description 20
- 238000002679 ablation Methods 0.000 claims abstract description 13
- 230000007246 mechanism Effects 0.000 claims abstract description 11
- 206010001497 Agitation Diseases 0.000 claims abstract description 8
- 210000003734 kidney Anatomy 0.000 claims description 20
- 230000005540 biological transmission Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000010304 firing Methods 0.000 claims description 3
- 210000003195 fascia Anatomy 0.000 claims description 2
- 230000002459 sustained effect Effects 0.000 claims description 2
- 230000005619 thermoelectricity Effects 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 abstract description 17
- 230000036772 blood pressure Effects 0.000 abstract description 13
- 230000001631 hypertensive effect Effects 0.000 abstract description 4
- 210000001186 vagus nerve Anatomy 0.000 abstract 2
- 230000001276 controlling effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000004804 winding Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- 230000001053 orthosympathetic effect Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 210000002820 sympathetic nervous system Anatomy 0.000 description 4
- 208000004531 Renal Artery Obstruction Diseases 0.000 description 3
- 206010038378 Renal artery stenosis Diseases 0.000 description 3
- 230000002638 denervation Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 229940127088 antihypertensive drug Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002687 intercalation Effects 0.000 description 2
- 238000009830 intercalation Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 210000000607 neurosecretory system Anatomy 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000008288 physiological mechanism Effects 0.000 description 2
- 230000008660 renal denervation Effects 0.000 description 2
- 208000037905 systemic hypertension Diseases 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 206010059245 Angiopathy Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000013153 catheter ablation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Images
Abstract
The invention discloses a radiofrequency ablation device which is used for removing the vagus nerve of the renal artery and reducing excitability of the renal sympathetic nerve. The radiofrequency ablation device comprises an ablation electrode capable of partially or wholly winding the renal artery and carrying out radiofrequency ablation operation on the renal artery and an operation mechanism for controlling movement of the ablation electrode and achieving the objective that the electrode winds the renal artery. The radiofrequency ablation device is connected with a radio frequency generator, removes the vagus nerve of the renal artery through radiofrequency ablation, reduces excitability of the renal sympathetic nerve and plays a role of regulating the blood pressure of a refractory hypertensive.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, be specifically related to a kind of RF ablation device, particularly relate to and a kind ofly for renal artery, remove orthosympathetic RF ablation device, reduce the kidney sympathetic excitability, be used for the treatment of intractable hypertension.
Background technology
Hypertension is the Major Risk Factors of apoplexy, coronary heart disease, heart failure, angiopathy and chronic renal failure.Hypertension is suffered from the whole world approximately 1,000,000,000 adults, wherein only 1/3 obtains effectively to control.Underdiagnosis and to treat compliance poor be one of not good enough reason of curative effect, even but a large amount of patient accepts the optimal drug treatment still can not be effectively controlled.In fact, in clear and definite clinical trial at present, the patient of nearly 20%-30% fails to reach target blood pressure (even having accepted to surpass 3 kinds of treated with combined medications), finally develops into intractable hypertension.
So-called intractable
Hypertension2008 american heart association (AHA) it is defined as: improve through life style, take simultaneously the antihypertensive drugs (wherein a kind of for diuretic) of 3 kinds of different mechanism of action, or need at least 4 kinds of medicines systolic pressure and diastolic pressure could be controlled at target level (＜140/90mmHg).
Although hypertensive pathology, physiological mechanism are complicated, neuroendocrine system is to keep the important mechanisms of blood pressure balance, and it is orthosympathetic is overexcited and is considered to the basic link of hypertension incidence.A large amount of zooperies and clinical research also confirm the impact of sympathetic nervous system on blood pressure, find that orthosympathetic excitement degree and patient's blood pressure level is proportionate.Wherein, the kidney sympathetic nervous system is kidney Sympathetic Nerve and the nervus centripetalis of the most close renal artery wall particularly, for bringing out and causing that systemic hypertension plays decisive role, thereby forms the theory that blocking-up kidney sympathetic nerve can reduce blood pressure.
Theoretical and orthosympathetic experience of early stage surgical excision based on this, " percutaneous catheter kidney sympathetic nerve radio-frequency ablation procedure " treatment intractable hypertension was explored by American-European countries since 2007, obtained satisfied curative effect, for the treatment of intractable hypertension provides new thinking and method.after the interventional technique femoral artery puncture that the method employing doctor is familiar with, renal artery is carried out wall melt to block the transmission of kidney sympathetic signal, the SymplicityTM kidney denervation system that mainly comprises Medtronic, the OneShotTM kidney Renal denervation system of Coyidien, the V2 kidney denervation system of the Enlig HNTTM kidney Renal denervation system of St.Jude and Vessix Vascular, these products have all obtained the CE authentication, and SymplicityTM kidney denervation system also obtains the TGA authentication, clinical effectiveness confirms that these products reach does not affect other abdominal paries in blood pressure lowering, pelvis or lower limb nerve domination, for the treatment of intractable hypertension provides new thinking and method.
Although a large amount of clinical effectivenesses confirm, the reduction that the blood pressure that adopts this kind internal medicine ablation catheter to treat rear patient has persistence, the method is had relatively high expectations to patient itself.As there not being the problems such as renal artery stenosis, branched renal artery; Because sympathetic nerve is positioned at the renal artery adventitia, catheter ablation just need to melt wall with tremulous pulse in addition, and this is larger to the renal artery infringement, easily causes renal artery stenosis; The ablation points position is not easy to hold, and these all cause the limitation of its application.Therefore, adopt the Surgical laparoscope technology directly outside renal artery, sympathetic nerve to be melted, can effectively be applied to exist the patient of renal artery deformity, the while is snap action renal artery outer wall sympathetic nerve directly, reduces arteriorenal infringement.
Summary of the invention
The purpose of this invention is to provide a kind of medical apparatus and instruments, adopt radio-frequency ablation technique, can be used for removing the renal artery sympathetic nerve, reduce the kidney sympathetic excitability, the treatment intractable hypertension.
The invention provides a kind of RF ablation device, be used for removing the renal artery sympathetic nerve, reduce the kidney sympathetic excitability, this device comprises: can and can carry out to renal artery the ablating electrode of radio-frequency (RF) ablation operation partly or entirely around renal artery; Control the motion of ablating electrode and realize electrode pair arteriorenal around operating-controlling mechanism.
Described ablating electrode consists of electrode member, electrode tip holder and temperature sensor.
Described electrode member is bipolar electrode pair, can act on after pairing; Wherein electrode member is device or the combinations such as wire electrode, electrode retaining collar or electrode slice.
Described electrode tip holder is that the collet of electrode member supports, and supports the electrode member on it.
Described temperature sensor is thermoelectricity resistance type or thermocouple type.
Described thermal resistance or thermocouple can provide feedback signal, are used for tissue temperature around measuring transducer, wherein feedback signal with to survey tissue temperature proportional.
Described temperature sensor can be controlled at zone of ablation renal artery temperature any temperature range in 37-200 ℃ of scope.Preferably, temperature range is controlled in 45-65 ℃.
During lower than 45 ℃, temperature sensor is with signal feedback to radio-frequency signal generator when temperature, and radio-frequency signal generator continuous firing, radio-frequency (RF) energy sustained delivery, to renal artery, avoid the renal artery temperature too low; Temperature is during higher than 65 ℃, and radio-frequency signal generator stops transferring energy, avoids the renal artery excess Temperature.
Described ablating electrode has Multiple Shape, is point-like, pliers shape, annular, ellipse, spiral type or rake shape, perhaps difform combination.
Described ablating electrode acts on outside the renal artery blood vessel, in fascia.Can block renal artery blood flow during ablating electrode work, also can keep renal artery unimpeded.
Described operating-controlling mechanism, can control ablating electrode motion, make its around or part around renal artery; And be connected with radio-frequency signal generator, with transmission of radio-frequency energy to ablating electrode.
Patient for intractable hypertension, under laparoscopically assistance, the passage of setting up by perforator, use this RF ablation device, renal artery sympathetic nerve to the patient carries out the radio-frequency (RF) ablation operation, removes the sympathetic nerve on renal artery, reduces the kidney sympathetic excitability, control/reduce patient's blood pressure, the treatment intractable hypertension.Can once melt, also can repeatedly melt, act on the renal artery middle part.
The advantage of this invention is, by peritoneoscope, directly melts the EV sympathetic nerve of renal artery, and operation quick and precisely; Melt and need not wall, the renal artery blood vessel injury is little; Need not to use developing agent and X ray, reduce to the murder by poisoning of kidney with to the radiation injury of human body; Clinical selected patient's expanded range, the patient who even has branched renal artery or renal artery stenosis also can adopt this mode.
Description of drawings
Fig. 1 is the overall schematic of an embodiment of RF ablation device of the present invention.
Fig. 2 a and Fig. 2 b are the structural representations of oval ablating electrode of the present invention.
Fig. 3 a is the structural representation of pliers shape ablating electrode of the present invention.
Fig. 3 b is the structural representation of spiral type ablating electrode of the present invention.
Fig. 3 c is the structural representation of rake shape ablating electrode of the present invention.
Fig. 4 a and Fig. 4 b are the schematic diagrams of operating-controlling mechanism of the present invention.
The specific embodiment
Structure and the working method of RF ablation device of the present invention are described in detail in detail below in conjunction with drawings and Examples.
2008 american heart association (AHA) with intractable
HypertensionBe defined as: improve through life style, take simultaneously the antihypertensive drugs (wherein a kind of be diuretic) of 3 kinds of different mechanism of action, or need at least 4 kinds of medicines systolic pressure and diastolic pressure could be controlled at target level (＜140/90mmHg).
Although hypertensive pathology, physiological mechanism are complicated, neuroendocrine system is to keep the important mechanisms of blood pressure balance, orthosympathetic be overexcited be considered to the basic link of hypertension incidence.A large amount of zooperies and clinical research also confirm the impact of sympathetic nervous system on blood pressure, find that orthosympathetic excitement degree and patient's blood pressure level is proportionate.Wherein, the kidney sympathetic nervous system is kidney Sympathetic Nerve and the nervus centripetalis of the most close renal artery wall particularly, for bringing out and causing that systemic hypertension plays decisive role, thereby forms the theory that blocking-up kidney sympathetic nerve can reduce blood pressure.
RF ablation device of the present invention, be used for melting and remove renal artery sympathetic nerve on every side, reduces the kidney sympathetic excitability, thereby reach the purpose for the treatment of intractable hypertension.
Fig. 1 has shown an illustrative schematic diagram of renal artery ablating device of the present invention, and this ablating device 100 comprises: 1) can be partly or entirely around renal artery, and can carry out to renal artery the ablating electrode 101 of radio-frequency (RF) ablation operation; 2) can control the motion of ablating electrode, and realize electrode pair arteriorenal all or part of around operating-controlling mechanism 102.
Show in Fig. 2 a and Fig. 2 b that ablating electrode 101 consists of electrode member 201, electrode tip holder 202 and temperature sensor 203.Fig. 2 a and Fig. 2 b be respectively ablating electrode 101 signal front view and launch top view fully, select two wire electrodes as in the parallel intercalation electrode seat 202 of electrode member 201, form electrode pair.Temperature sensor 203 is also in the intercalation electrode seat, and whether the discharge of regulation and control electrode member 201, reaches the purpose of controlling the zone of ablation temperature.Preferably, in 45-65 ℃ of scope, during lower than 45 ℃, the radio-frequency signal generator continuous firing, provide radio-frequency (RF) energy when temperature with Temperature Setting, and the electrode pair discharge, melt the sympathetic nerve on the renal artery pipe; During higher than 65 ℃, radio-frequency signal generator quits work when temperature, and electrode pair quits work, and anti-hemostatic tube is excessively melted.
Ablating electrode can be various shapes, and is oval as shown in Figure 2 a and 2 b, pliers shape as shown in Fig. 3 a, and spiral type as shown in Fig. 3 b, harrow shape as shown in Figure 3 c.When ablating electrode is worked, use pliers shape ablating electrode shown in Fig. 3 a, renal artery is blocked; While using ablating electrode shown in Fig. 2 a and Fig. 2 b, Fig. 3 b, 3c, it is unimpeded that renal artery keeps.
Shown in Fig. 4 a and Fig. 4 b, operating-controlling mechanism is the handle type controlling organization.Wherein, the handle control mechanism of Fig. 4 a signal is class pistol shape, by handle, controls, and can make ablating electrode around outside renal artery.Fig. 4 b handle type controlling organization is round bar shape, by the control of handle button, front end is wrapped in outside renal artery with the serpentine pipe of ablating electrode.Its concrete structure and operation principle can, by multiple existing techniques in realizing, not repeat them here.
Although described a plurality of embodiment, one of ordinary skill in the art appreciates that countless variations and/or revise and can make and can not break away from the broadly described spirit and scope of the present invention.Therefore, embodiments of the invention are all just illustrative in all senses, rather than restrictive.
The present invention is not limited to the particular content described in embodiment.Ground of the present invention renal artery ablating device goes also to can be used for the neural ablation of other blood vessel/tissue the hypertensive purposes of renal artery sympathetic nerve treatment except being applied to radio-frequency (RF) ablation.
Claims (12)
1. a RF ablation device, be used for removing the renal artery sympathetic nerve, reduces the kidney sympathetic excitability, it is characterized in that, this device comprises:
Can and can carry out to renal artery the ablating electrode of radio-frequency (RF) ablation operation partly or entirely around renal artery;
Control the motion of ablating electrode and realize electrode pair arteriorenal around operating-controlling mechanism.
2. RF ablation device according to claim 1, is characterized in that, described ablating electrode comprises the electrode tip holder of electrode member, temperature sensor, the described electrode member of support and temperature sensor.
3. RF ablation device according to claim 2, is characterized in that, described electrode member is bipolar electrode pair, the pairing effect.
4. RF ablation device according to claim 3, is characterized in that, described electrode member is wire electrode, electrode retaining collar or electrode slice one or a combination set of.
5. RF ablation device according to claim 2, is characterized in that, described temperature sensor is thermoelectricity resistance type or thermocouple type.
6. RF ablation device according to claim 5, is characterized in that, described thermal resistance or thermocouple are arranged to the tissue temperature around measuring transducer, and feedback signal is provided, described feedback signal with to survey tissue temperature proportional.
7. RF ablation device according to claim 6, is characterized in that, described temperature sensor is configured to the zone of ablation tissue temperature is controlled at a temperature range in 37-200 ℃ of scope.
8. RF ablation device according to claim 7, is characterized in that, described temperature range is 45-65 ℃.
9. RF ablation device according to claim 8, it is characterized in that, temperature sensor is configured to when described tissue temperature during lower than 45 ℃, described temperature sensor is given a radio-frequency signal generator with signal feedback, the radio-frequency signal generator continuous firing, the radio-frequency (RF) energy sustained delivery is given described tissue, avoids tissue temperature too low; Temperature is during higher than 65 ℃, and radio-frequency signal generator stops transferring energy, avoids described tissue temperature too high.
10. RF ablation device according to claim 1, is characterized in that, described ablating electrode is point-like, pliers shape, annular, ellipse, spiral type or rake shape.
11. RF ablation device according to claim 10, is characterized in that, described ablating electrode acts on outside the renal artery blood vessel, in fascia.
12. RF ablation device according to claim 1, is characterized in that, described operating-controlling mechanism is arranged to be connected with a radio-frequency signal generator, with transmission of radio-frequency energy, gives described ablating electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310340177.1A CN103393464B (en) | 2013-08-01 | 2013-08-01 | A kind of RF ablation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310340177.1A CN103393464B (en) | 2013-08-01 | 2013-08-01 | A kind of RF ablation device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103393464A true CN103393464A (en) | 2013-11-20 |
| CN103393464B CN103393464B (en) | 2016-08-10 |
Family
ID=49557348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310340177.1A Active CN103393464B (en) | 2013-08-01 | 2013-08-01 | A kind of RF ablation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103393464B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897712A (en) * | 2019-12-28 | 2020-03-24 | 苏州海普特斯医疗科技有限公司 | Cold saline perfusion radio frequency ablation forceps with controllable clamping force |
| US11576716B2 (en) | 2013-03-15 | 2023-02-14 | Medtronic Holding Company Sàrl | Electrosurgical mapping tools and methods |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6325796B1 (en) * | 1999-05-04 | 2001-12-04 | Afx, Inc. | Microwave ablation instrument with insertion probe |
| CN101027009A (en) * | 2004-05-14 | 2007-08-29 | 卡帝玛股份有限公司 | A system and method for multi-channel RF energy delivery with coagulum reduction |
| CN101309651A (en) * | 2005-06-20 | 2008-11-19 | 消融前沿公司 | Ablation catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202821618U (en) * | 2012-09-12 | 2013-03-27 | 屈百鸣 | Peritoneoscope renal artery sympathetic denervation ablation catheter |
-
2013
- 2013-08-01 CN CN201310340177.1A patent/CN103393464B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6325796B1 (en) * | 1999-05-04 | 2001-12-04 | Afx, Inc. | Microwave ablation instrument with insertion probe |
| CN101027009A (en) * | 2004-05-14 | 2007-08-29 | 卡帝玛股份有限公司 | A system and method for multi-channel RF energy delivery with coagulum reduction |
| CN101309651A (en) * | 2005-06-20 | 2008-11-19 | 消融前沿公司 | Ablation catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202821618U (en) * | 2012-09-12 | 2013-03-27 | 屈百鸣 | Peritoneoscope renal artery sympathetic denervation ablation catheter |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11576716B2 (en) | 2013-03-15 | 2023-02-14 | Medtronic Holding Company Sàrl | Electrosurgical mapping tools and methods |
| CN110897712A (en) * | 2019-12-28 | 2020-03-24 | 苏州海普特斯医疗科技有限公司 | Cold saline perfusion radio frequency ablation forceps with controllable clamping force |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103393464B (en) | 2016-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6905759B2 (en) | Systems and methods for positioning and identifying the functional nerves that innervate the arterial wall and their catheters | |
| US20230314268A1 (en) | Apparatus and methods for treating rhinitis | |
| US11324408B2 (en) | Mapping sympathetic nerve distribution for renal ablation and catheters for same | |
| CN203122581U (en) | Catheter with function of mapping kidney nerves | |
| US20180116704A1 (en) | Methods and devices for cryogenic carotid body ablation | |
| ES2386829T3 (en) | Apparatus, systems and methods to achieve thermally induced intravascular renal neuromodulation | |
| JP5952356B2 (en) | NEURONAL MODULATION METHOD AND DEVICE THEREOF | |
| US9439722B2 (en) | Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension | |
| JP2021511163A (en) | Methods and devices for intravascular ablation of the splanchnic nerve | |
| CN106102619B (en) | Catheter with independent radial expansion member and associated devices, systems, and methods | |
| WO2014008489A1 (en) | Devices and systems for carotid body ablation | |
| CN103750898B (en) | A kind of intraluminal ablation catheter | |
| JP2015526177A5 (en) | ||
| EP2840993A1 (en) | Endovascular catheters and methods for carotid body ablation | |
| TW201223583A (en) | Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods | |
| CN104257426B (en) | A kind of arteria renalis with sealing valve removes sympathetic nerve cool brine radio frequency ablation catheter | |
| CN104768486A (en) | Neuromodulation catheters and associated systems and methods | |
| EP2851027A1 (en) | Ablation catheter devices and methods | |
| CN111511302A (en) | Systems, devices, and associated methods for neuromodulation with enhanced nerve targeting | |
| CN103393464A (en) | Radiofrequency ablation device | |
| CN204169925U (en) | A kind of electrophysiologicalcatheter catheter | |
| CN105615990B (en) | A kind of electrophysiologicalcatheter catheter | |
| CN103393465B (en) | A kind of RF ablation device | |
| CN110063784A (en) | A kind of annular mapping catheter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 101312 No.5, Zhuyuan 2nd Street, Shunyi District, Beijing (Tianzhu Comprehensive Bonded Zone) Patentee after: Beijing medipeak Medical Technology Co.,Ltd. Address before: 101312 No.5, Zhuyuan 2nd Street, Shunyi District, Beijing (Tianzhu Comprehensive Bonded Zone) Patentee before: BEIJING MED ZENITH MEDICAL SCIENTIFIC Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| IP01 | Partial invalidation of patent right |
Commission number: 4W113972 Conclusion of examination: Declare partial invalidity of invention No. 201310340177.1, and continue to maintain the validity of the patent on the basis of claims 1-9 submitted by the patentee on May 16, 2022 Decision date of declaring invalidation: 20221101 Decision number of declaring invalidation: 58923 Denomination of invention: A radiofrequency ablation device Granted publication date: 20160810 Patentee: Beijing medipeak Medical Technology Co.,Ltd. |
|
| IP01 | Partial invalidation of patent right |