CN103349747A - Traditional Chinese medicine preparation for preventing and curing paralichthys olivaceus and sea cucumber scuticoci liatlda diseases - Google Patents
Traditional Chinese medicine preparation for preventing and curing paralichthys olivaceus and sea cucumber scuticoci liatlda diseases Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for preventing and curing paralichthys olivaceus and sea cucumber scuticoci liatlda diseases. The preparation comprises the following traditional Chinese medicine components in percentage by weight: 5-20 percent of abrotanum, 5-20 percent of azedarach, 5-20 percent of cyrtomium fortunei, 5-40 percent of stemona, 5-20 percent of golden cypress, 5-20 percent of betel nut and 5-30 percent of omphalia, and the sum of the weight percentages are 100. According to the invention, medicines with components restraining or killing pathogens are selected to make a formula on the basis of traditional Chinese theories, breeding bait is added and absorbed by the host of a parasite, scuticoci liatldas parasitizing in the body or on the body surface of the host of the parasite are completely killed in a body fluid absorbing and supplying way, so that the traditional Chinese medicine preparation has the advantages that medicine feeding is simple, the medicine effect is quick, the insert killing effect is good, the recovery of the physique of the host of the parasite is quick, the survival rate is high, side effects and medicine residue are avoided, as a result, economical loss caused by scuticoci liatlda infection during the production processes of breeding and growing.
Description
Technical field
The present invention relates to a kind of medicament preparation, especially a kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease.
Background technology
In recent years, along with the continuous expansion of cultivation scale, the continuous increase of regional cultivation density, no matter breed variety is in the seed rearing stage, or in forming process, the farming disease harms happens occasionally, especially the parasite type disease take the shield ciliate as main infection source harm is quite large, has had a strong impact on the survival rate of Cultured Flounder, Paralichthys Olivaceus fish, Radix Morinae Bulleyanae, it is one of comparatively serious disease of breeding production harm, also affected simultaneously the quality of cultivation object, caused production cost to increase, economic benefit is impaired.
The shield ciliate is named again and is had a liking for rotten worm, the shield balantidiasis that infects is commonly referred to balantidiasis, this disease sickness rate is high, and infection velocity is fast, and the popular time is long, often and other bacterial diseasees concurrent, can colonize in the body surface of fish, ginseng, also can parasitism in vivo, especially colonize in brain, spleen, kidney, liver and the blood of fish, also do not have at present specific short, can cause the large quantities of death of the infected.In addition, Radix Morinae Bulleyanae also can be often infected in the seed rearing stage, joined ingestion ability by parasitic children and descend, and stops gradually ingesting, and it is dead finally to quantize greatly skin, then infects other individualities, causes full pond dead.
In recent years, the world biological person has obtained some comparatively desirable effects exploring widely aspect the prevention of this disease and the treatment, has researched and developed multiple therapy methods.As adopt and change the breeding water body salinity, the method for regulating osmotic pressure is embathed the cultivation object and is reached and remove ectozoal purpose; Adopt the different ions such as copper, zinc, hydrargyrum to embathe the debug method; Hydrogen peroxide bathing debug method, the multiple methods of preventing and treating such as formalin debug method and the debug method of taking to heat up, lower the temperature all obtain extensive and long-term application in breeding production, but production practices prove, adopt above-mentioned technology prevention method can only obtain the therapeutic effect of short time, very difficult radical cure more can not be killed parasitic ciliate in vivo, and cause drug residue, so in breeding production, this disease still can cause very large economic loss.
Summary of the invention
Methods from outer treatment in order to overcome applied various Prevention Technique in the prior art, can only be extremely except the shield ciliate that colonizes in body surface, and relapse rate is high, the probability of repeated infection is large, and can't kill parasitic ciliophoran deficiency in vivo, the invention provides a kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease.This Chinese medicine preparation does not affect the cultivation object and ingests and activity, do not affect its growth, and to parasitism in vivo, the shield Infusoria of body surface has good killing action, good disinsection effect, it is fast that host's body constitution is recovered, survival rate is high, can greatly reduce in cultivation, the production process of growing seedlings and infect the economic loss that causes because of the shield ciliate.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, it is characterized in that: be to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 5-20%, Cortex Meliae 5-20%, Rhizoma Osmundae 5-20%, Radix Stemonae 5-40%, Cortex Phellodendri 5-20%, Semen Arecae 5-20% and Omphalia 5-30%, its weight percentages of components sum is 100%.
The consumption of described Chinese medicine preparation is 3 ‰ of breeding bait weight-8 ‰.
The selection of Chinese medicine preparation of the present invention and prescription are to select that according to tcm theory the medicine that suppresses or kill the pathogen composition is arranged, and in this Chinese medicine preparation: Herba Artemisiae Annuae bitter in the mouth, property suffering are trembled with fear, and have clearind deficient heat, separate summer-heat, the effect of preventing the attack (or recurrence) of malaria; Modern study shows: Herba Artemisiae Annuae mainly contains sesquiterpenoids, flavonoid, Coumarins, volatile ingredient and other beta galactosidases, beta-glucosidase, cupreol etc., and wherein sesquiterpenoids has arteannuin, artelinic acid, artemisinol, methyl arteannuate etc.; Its arteannuin and derivant have the bilharzial effect of anti-animal; Arteannuin, SM-224, artesunate all can promote the immunization of body cell; Herba Artemisiae Annuae decocting liquid has lethal effect to various bacteria, virus.Cortex Meliae bitter in the mouth, cold in nature has parasite killing, treats the effect of tinea; Modern study shows: Cortex Meliae contains Azedarachin, Cen skin ketone, bitter lactone, melianotriol, positive state alkane, cupreol, Fructus Toosendan ketone etc.; Contained main component Azedarachin drives the ascarid effect, and its melianol immersion or water extract have obvious inhibitory action to common pathogenic fungus.Rhizoma Osmundae bitter in the mouth, cold nature have heat-clearing and toxic substances removing, the effect of hemostasis parasite killing; Modern study shows: the Rhizoma Osmundae main component is pannol, is a kind of phloroglucinol derivant of complexity, can slowly decompose and produces albaspidin and white albaspidin; Contain again aspidinol, flavaspidic acid, filicinic acid; Other contains volatilization sleeve, filicitannic acid, fat, resin etc.; Still contain triterpenoid fernene, jasmine alkene-b, adianton, jasmine alcohol, pure-29 wild goose tooth alkene of jasmine etc.; Its contained Filixic Acids, flavaspidic acid have stronger anthelmintic action, and cestode is had strong toxicity, can make cestode benumb and discharge, and the parasitic effects such as the ancylostome of expeling, ascarid are also arranged; Rhizoma Osmundae has obvious inhibitory action to multiple Causative virus, fungus.Radix Stemonae sweet in the mouth, hardship, slightly warm in nature has the effect of nourishing the lung to keep the adverse QI downward, parasite killing delousing; Modern study shows: the Radix Stemonae contains multiple alkaloid: such as (-)-Stemoninine, Stemonidine, protostermonine, inferior (-)-Stemoninine, sessilistemonine, tuberostemonine, stemonamine etc., also contain sugar, lipid, protein and acetic acid, formic acid, malic acid, succinic acid, oxalic acid etc.Its melianol immersion or water extract are to various pathogens such as streptococcus pneumoniae, beta hemolysis type streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus and dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis, and vibrio cholera, Bacillus tuberculosis etc. have bacteriostasis in various degree; Some pathomycete there is certain inhibitory action; In addition, its infusion and ethanol immersion all have killing action to mosquitos and flies larva, head louse, clothing louse and Cimex bedbug etc.The Cortex Phellodendri bitter in the mouth, cold in nature, have heat clearing and damp drying, pathogenic fire purging except steaming, detoxify treatment skin ulcer effect; Modern study shows: the Cortex Phellodendri bark contains the alkaloids such as berberine, jateorhizine, magnoflorine, phellodendrine, candicine, palmatine, Dauricine; Other contains obacunone, obakulactone, Dictamnolide, obacunonic acid, the acid of blue or green fluorescent, 7-dehydrogenation stigmasterol, cupreol, campesterol.Cortex Phellodendri has the resisting pathogenic microbes effect, and the multiple malignant bacterias such as dysentery bacterium, Bacillus typhi, staphylococcus aureus, Hemolytic streptococcus are all had inhibitory action; Its decoct or preserved material have in various degree bacteriostasis to some common pathogenic funguses.Semen Arecae bitter in the mouth, property suffering have the effect of killing insect and eliminating accumulation, promoting the circulation of QI to induce diuresis, preventing the attack (or recurrence) of malaria; Modern study shows: Semen Arecae contains alkaloid 0.3～0.6%, condensed tannin 15%, fat 14% and areca red.The alkaloid master is arecoline, content 0.1～0.5%; All the other have arecaidine, demethyl arecaidine, guvacoline, arecolidine, homarecoline etc.; Bulky alkali is effective anthelmintic ingredient, and cestode, pinworm, ascarid, ancylostome, schistosomicide etc. are all had paralysis or kill effect; Its contained tannin is to all having inhibitory action to multiple Causative virus, fungus.The selected crude drug of the present invention to the cultivation object without noci-influence, the effect that not only has parasite killing, anthelmintic, and have hemopoietic or promote effect and the hepatic cholagogic that body fluid circulates, stomach invigorating is eaten by force, strengthening vital QI to eliminate pathogenic factors, health invigorating and scalable glandular secretion can improve cultivation object autoimmune function.Omphalia is the bacterium sclerotium of Polyporaceae plant Omphalia lapidescens, and its mildly bitter flavor is cold in nature, has the effect of killing insect and eliminating accumulation; Modern study shows: main component is that a kind of protease claims Omphalin, and content is about 3%, for the expelling tenia effective ingredient, adds thermal failure; The expelling tenia effect of Omphalia is not the paralysis polypide, but owing to the decomposition of the protease in the Omphalia to protein, destroys worm and save deadly dying.
Chinese medicine preparation of the present invention is to add in the breeding bait, the host ingest by the absorption of body fluid and supply method thoroughly kill parasitic in vivo with the shield ciliate of body surface, not affecting the cultivation object ingests and activity, do not affect its growth, a kind of raising host autoimmunity, to the Chinese medicine preparation of internal therapy.The Chinese medicine preparation of this control Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, administration is simple to operate, drug effect is fast, good disinsection effect, host's body constitution recover fast, and input cost is low, survival rate is high, have no side effect, drug residue free can greatly reduce in cultivation, the production process of growing seedlings and infect the economic loss that causes because of the shield ciliate.
The specific embodiment
Below in conjunction with embodiment and effect experiment the present invention is described in further details.
Embodiment
1
A kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, is to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 5%, Cortex Meliae 15%, Rhizoma Osmundae 20%, the Radix Stemonae 10%, Cortex Phellodendri 5%, Semen Arecae 20% and Omphalia 25%.
Embodiment
2
A kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, is to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 15%, Cortex Meliae 20%, Rhizoma Osmundae 5%, the Radix Stemonae 15%, Cortex Phellodendri 15%, Semen Arecae 15% and Omphalia 15%.
Embodiment
3
OnePlant the Chinese medicine preparation of control Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, is to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 20%, Cortex Meliae 5%, Rhizoma Osmundae 15%, the Radix Stemonae 5%, Cortex Phellodendri 20%, Semen Arecae 5% and Omphalia 30%.
Embodiment
4
OnePlant the Chinese medicine preparation of control Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, is to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 12%, Cortex Meliae 12%, Rhizoma Osmundae 8%, the Radix Stemonae 40%, Cortex Phellodendri 13%, Semen Arecae 10% and Omphalia 5%.
Embodiment
5
A kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, is to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 10%, Cortex Meliae are 10%, Rhizoma Osmundae is 10%, the Radix Stemonae is 30%, Cortex Phellodendri is 10%, Semen Arecae is 10% and Omphalia 20%.
In above-described embodiment, be to take by weighing respectively raw material of Chinese medicine Herba Artemisiae Annuae, Cortex Meliae, Rhizoma Osmundae, the Radix Stemonae, Cortex Phellodendri, Semen Arecae, Omphalia, these several raw material of Chinese medicine are broken into fine powder through superfine powder, behind mistake 150 orders-200 mesh sieve, packed sealing behind abundant mix homogeneously.During use, Chinese medicine preparation is added in the breeding bait, fully mix mixing thoroughly, or be diluted to juice with clean water and evenly be sprayed at the feedstuff surface with miniaturised nebuliser, the use of throwing something and feeding after drying a little.
A kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, its effect experiment is as follows:
One, the effect experiment of control Paralichthys olivaceus shield ciliate disease
1, prepares the test net cage: in the ciliate spot, at first select 3 net cages that morbidity is serious, concentrate the morbidity Paralichthys olivaceus in two net cages wherein.
2, test fish specification and density: morbidity fish size 15-25cm, each proof box 500 tail.
3, administration time and administrated method: with 3 ‰ and 10 ‰ medication amount, two casees test fishes of throwing something and feeding, take medicine bait twice every day respectively, throws once morning, and at dusk throwing once.Threw something and fed continuously 20 days.
4, result of the test: in this test originally, ingest normally with the test fish of 3 ‰ dosages, and tell the food phenomenon with the fish body in the proof box of 10 ‰ dosages.Next day two kinds of administration ratios are passed up and down accent separately, soon transfer at 9 ‰ o'clock on 3 ‰ the dosage, the food phenomenon appears telling in indivedual fish bodies; Ratio with 10 ‰ is adjusted downward at 8 ‰ o'clock, and the fish body is ingested normally, does not tell the food phenomenon.For this reason, the scope for the treatment of dosage is defined as 3 ‰-8 ‰, and continues administration with 8 ‰ ratio.Pharmaceutical chemistry is fed to field observation in the 7th day, and the sick fish state of two proof boxs is clearly better, and the daily mortality amount descends day by day, and the fish body enlivens, robs food, body colour is good, and fin launches, and body surface secretions obviously reduces, dead individual obvious decline.Medication 10 days, the state of an illness is substantially controlled.Medication 15 days, two test net cages do not have dead individual again.Medication 20 days, fish body recover normal, respectively fish for respectively 10 tail fishes, and microscopy body surface position and brain, blood and internal organs are not all found ciliate.The sampling microscopy, equal fibre-less worm in body surface, the body.Illustrate that this medicine has significant therapeutic effect to Paralichthys olivaceus shield ciliate.
Two, control Radix Morinae Bulleyanae shield ciliate disease effect experiment
1, chooses the morbidity seedling in three ponds.
2, test sea cucumbers specification and density: morbidity seedling specification be 1000-500 jin.20 jin of every pond sea cucumbers gross weights.
3, administration time and administrated method: consider that the sea cucumbers body is little enervated, with 3 ‰, 5 ‰, 8 ‰ the medication amount tested sick ginseng of throwing something and feeding respectively, every day, bait throwing in twice respectively, and throws once morning, and at dusk throwing was was once thrown something and fed 5-7 days continuously.
4, result of the test: the phenomenon that the same day of the 8 ‰ medication amount pharmaceutical chemistry of throwing something and feeding, sea cucumbers was assumed an air of complacency just obviously reduces, the throw something and feed second day of pharmaceutical chemistry, the sea cucumbers of changing skin obviously reduces, throw something and feed the 3rd day of pharmaceutical chemistry, the sea cucumbers body surface by ciliate attack to destroy form the eyelet that festers, mashed point namely obtains repairing, the medicine to that continues to throw something and feed obtained thoroughly recovery from illness in 7 days.By observing, the throw something and feed corresponding prolongation of sea cucumbers cure time of 8 ‰ medication amount pharmaceutical chemistry of the sea cucumbers cure time of 5 ‰, 3 ‰ medication amount pharmaceutical chemistry of throwing something and feeding, but in the process of throwing something and feeding, the throw something and feed sea cucumbers mortality rate of 8 ‰ medication amount pharmaceutical chemistry of its sea cucumbers skin mortality rate is high, builds and adopts the treatment of throwing something and feeding of 5 ‰-8 ‰ medication amount pharmaceutical chemistry.
Through test determination: the Chinese medicine preparation of control Paralichthys olivaceus of the present invention, Radix Morinae Bulleyanae shield ciliate disease reaches 100% to effective prevention rate of Paralichthys olivaceus, Radix Morinae Bulleyanae ciliate disease, and effectively cure rate reaches more than 87%.
Chinese medicine preparation medicine character of the present invention is stable, and nonirritant has no side effect, and without residual in the body, does not also have teratogenesis, a phenomenon that disables, and the cultivation object without nocuity, is had the advantage that application cost is low, preventive effect good, cure rate is high, easy to operation.In seawater seed rearing and intensive culture production, have broad application prospects.
Claims (2)
1. Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease, this Chinese medicine preparation is powder, it is characterized in that: be to be pulverized by weight percentage by following traditional Chinese medicine raw to form: Herba Artemisiae Annuae 5-20%, Cortex Meliae 5-20%, Rhizoma Osmundae 5-20%, Radix Stemonae 5-40%, Cortex Phellodendri 5-20%, Semen Arecae 5-20% and Omphalia 5-30%, its weight percentages of components sum is 100%.
2. a kind of Chinese medicine preparation of preventing and treating Paralichthys olivaceus, Radix Morinae Bulleyanae shield ciliate disease according to claim 1, it is characterized in that: the consumption of described Chinese medicine preparation is 3 ‰ of breeding bait weight-8 ‰.
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| CN110075144A (en) * | 2019-06-19 | 2019-08-02 | 北京生泰尔科技股份有限公司 | Rhizoma Et Radix Notopterygii is preparing the application in anti-shield infusorian drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103609861A (en) * | 2013-11-26 | 2014-03-05 | 青岛嘉瑞生物技术有限公司 | Traditional Chinese herbal medicinal feed additive for preventing balantidiasis of penaeus monodon |
| CN103609861B (en) * | 2013-11-26 | 2015-03-04 | 青岛嘉瑞生物技术有限公司 | Traditional Chinese herbal medicinal feed additive for preventing balantidiasis of penaeus monodon |
| CN104189313A (en) * | 2014-09-19 | 2014-12-10 | 山东新希望六和集团有限公司 | Medicinal composition for treating crucian carp ichthyoxeniosis and preparation method thereof |
| CN104367907A (en) * | 2014-11-27 | 2015-02-25 | 贵州省畜牧兽医研究所 | Chinese herbal medicinal sheep tick resisting agent as well as preparation method and using method thereof |
| CN104367907B (en) * | 2014-11-27 | 2017-08-22 | 贵州省畜牧兽医研究所 | A kind of Chinese herbal medicine sheep tick insect resistant agent and its preparation and application method |
| CN104800469A (en) * | 2015-05-20 | 2015-07-29 | 山东亚康药业股份有限公司 | Traditional Chinese medicine preparation for treating pathogenesis of turbot of aquatic animals |
| CN105766719A (en) * | 2016-03-22 | 2016-07-20 | 五河县金塘水产养殖有限公司金贸园分公司 | Breeding method for preventing and controlling ciliophora disease of mandarin fish |
| CN105770438A (en) * | 2016-03-22 | 2016-07-20 | 五河县金塘水产养殖有限公司金贸园分公司 | Medicament composition for preventing and treating siniperca chuatsi ciliate |
| CN105918166A (en) * | 2016-04-25 | 2016-09-07 | 固镇县益民养殖专业合作社 | Breeding method used for preventing and treating Ciliophora disease of Siniperca chuatsi |
| CN106309866A (en) * | 2016-09-30 | 2017-01-11 | 威海虹润海洋科技有限公司 | Traditional Chinese medicine preparation for preventing and treating stichopus japonicas mouthpart fester diseases and skin ulcerative diseases and preparation method thereof |
| CN110075144A (en) * | 2019-06-19 | 2019-08-02 | 北京生泰尔科技股份有限公司 | Rhizoma Et Radix Notopterygii is preparing the application in anti-shield infusorian drug |
| CN110075144B (en) * | 2019-06-19 | 2021-06-11 | 北京生泰尔科技股份有限公司 | Application of notopterygium root in preparing medicine for resisting scuticociliatida |
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