CN103327999B - 促进脂肪分解组合物 - Google Patents
促进脂肪分解组合物 Download PDFInfo
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- CN103327999B CN103327999B CN201280005753.0A CN201280005753A CN103327999B CN 103327999 B CN103327999 B CN 103327999B CN 201280005753 A CN201280005753 A CN 201280005753A CN 103327999 B CN103327999 B CN 103327999B
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- steatolysis
- lactoferrin
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Abstract
本发明的目的是提供含有乳铁蛋白和其他的成分组合而成的组合物，其具有显著的促进内脏脂肪分解的效果。即本发明提供：含有（A）乳铁蛋白和（B）选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花提取物以及可可提取物所组成的组中的1种以上的成分的促进脂肪分解组合物；所述促进脂肪分解组合物是食品、饲料或者药品；将所述成分（A）和成分（B）添加入食品或者饲料中从而赋予食品或者饲料促进脂肪分解效果的方法。
Description
技术领域
本发明涉及促进脂肪分解组合物。
背景技术
现代社会中由于慢性的营养摄取量多并且慢性的运动不足等而导致体内有蓄积脂肪的倾向。内脏脂肪是分泌增高高血压、高血糖、高血脂症等的风险的有害的脂肪细胞因子的组织。因而，正在开展对于具有不会过度减少内脏脂肪的功能的材料的开发。这样的材料例如，有通过运动的同时摄取从而发挥效果的儿茶素类（非专利文献1），抑制脂肪的吸收的多酚类（非专利文献2）等的报告。
专利文献1中记载了，乳铁蛋白与促进血液循环剂的组合通过抑制脂肪的蓄积而发挥降低内脏脂肪的效果。
在先行技术文献
专利文献
专利文献1日本专利特开2008-69121号公报
[非专利文献]
非专利文献1国际肥胖期刊（International Journal of Obesity）（2002）26，1459-1464
非专利文献2药理与治疗（药理と治疗）32（6），335-342（2004）
发明内容
发明要解决的课题
但是，不可以说上述以往的通过乳铁蛋白和促进血液循环剂的组合降低内脏脂肪的效果是充分的。
本发明的目的是提供含有乳铁蛋白和其他的成分的组合物，该组合物具有显著的促进内脏脂肪分解的效果。
解决课题的方法
本发明提供以下的发明。
〔1〕一种促进脂肪分解组合物，其含有（A）乳铁蛋白和（B）选自于丛梗藻（Durvillea）提取物、覆盆子酮（Raspberryketone）、洋蓟（Artichoke）叶提取物、迷迭香（Rosemary）提取物、异黄酮、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花（Coleusforskohlii）提取物以及可可提取物所组成的组中的1种以上的成分。
〔2〕上述〔1〕中所述的促进脂肪分解组合物是食品、饲料或者药品。
〔3〕一种将促进脂肪分解的效果赋予食品或者饲料的方法，向食品或者饲料中添加（A）乳铁蛋白和（B）选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花提取物以及可可提取物所组成的组中的1种以上的成分。
本发明也可以是以下的方式。
〔4〕一种促进实验对象的脂肪分解的方法，其通过将含有（A）乳铁蛋白和（B）选自于丛梗藻提取物，覆盆子酮，洋蓟叶提取物，迷迭香提取物，异黄酮，葡萄籽提取物，松树皮提取物，毛喉鞘蕊花提取物以及可可提取物所组成的组中的1种以上的成分的促进脂肪分解组合物用于实验对象。
〔5〕如〔4〕所述的促进脂肪分解方法，所述促进脂肪分解组合物是经口给与的。
〔6〕如〔5〕所述的促进脂肪分解方法，所述促进脂肪分解组合物是食品、饲料或者药品的方式。
发明效果
本发明的促进脂质分解组合物发挥成分（A）和成分（B）的协同效果，具有从各成分单独的效果预测不到的显著的促进脂肪分解的作用。
具体实施方式
本发明的促进脂肪分解组合物含有以下的成分（A）和成分（B）。
（A）乳铁蛋白
（B）选自于覆盆子酮、洋蓟叶提取物、可可提取物、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花提取物、丛梗藻提取物、迷迭香提取物以及异黄酮组成的组中的1种以上的成分
成分（A）是乳铁蛋白。乳铁蛋白的例子如下所述：市售的乳铁蛋白；从哺乳类（例如人、牛、羊、山羊、马等）的初乳、过渡乳、成熟乳、晚期乳等或者作为这些乳的加工产物的脱脂乳、乳清等中通过通常的方法（例如，离子交换色谱法）分离的乳铁蛋白；从植物（番茄、水稻、烟草）中生产的乳铁蛋白；通过基因重组而得到的乳铁蛋白。乳铁蛋白可以使用市售品，也可以使用通过公知方法制备的。
乳铁蛋白可以1种单独使用，也可以2种以上适当组合使用。乳铁蛋白优选来源于牛的乳铁蛋白。
本发明的组合物中的成分（A）的混合量，以每日人的摄取量计，通常为5mg～5,000mg/日，优选50mg～1,000mg/日，进一步优选100mg～500mg/日。通过在这个范围内，能得到促进脂肪分解效果显著优异的促进脂肪分解组合物。此外，该组合物的成本、安全性等方面也没有问题。
成分（B）为选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花提取物以及可可提取物组成的组中的1种以上的成分。
（B-1）丛梗藻提取物
丛梗藻提取物是丛梗藻的提取物。丛梗藻是属于丛梗藻科（Durvilleaceae）丛梗藻属（Durvillea）的海藻，南极洲丛梗藻（Durvillea antarctica），Durvillea potatorum，Durvilleawillana等被称为巨藻（Bull kelp）。丛梗藻提取物可以是丛梗藻的植物体的整体以及一部分中的任意一个的提取物。提取物的制备条件没有特别的限定，作为溶剂，优选含有醇的溶剂，更优选醇/水为0/100～70/30（V/V：体积比）的溶剂，更优选醇/水为0/100～40/60的溶剂。提取温度没有特别限定，通常为5～80℃，优选5～50℃。提取时间通常为1～24小时。提取优选在搅拌的同时进行。提取pH只要没有极端的酸性、碱性的倾向就没有特别的限定。
（B-2）覆盆子酮
覆盆子酮是4-（4-羟苯基）-2-丁酮以及/或者对羟基苄基丙酮。覆盆子酮是覆盆子的香味成分之一。覆盆子酮可以来源于属于蔷薇科悬钩子属的植物（例：覆盆子）的植物体（例：灌木、果实）等的天然产物，也可以是通过化学合成的人工制造的物质。
来源于天然产物的覆盆子酮可列举例如，属于蔷薇科悬钩子属（Rubus）的植物的植物体的提取物（以下称为覆盆子提取物）。属于蔷薇科悬钩子属的植物可列举优选的覆盆子。覆盆子（英语：raspberry，法语：framboise（フランボワーズ））学名RubusidaeusL.，Rubus strigosus，在分类学上相当于空心莓（Idaeobatus）亚属。得到覆盆子提取物时的植物体的提取部位可以是植物体整体以及一部分中的任意一个，优选灌木、果实等。提取溶剂、提取温度等的制备条件没有特别的限定。覆盆子提取物的纯度只要含有覆盆子酮就没有特别的限定。
（B-3）洋蓟叶提取物
洋蓟叶提取物是洋蓟（学名Cynara scolymus L.（Compositae））的叶的提取物。洋蓟叶提取物可以是叶的一部分以及全部中的任意一个的提取物。提取物的制备条件没有特别的限定，作为溶剂，优选醇，更优选乙醇。
洋蓟叶提取物中含有菜蓟苦素（2-（羟基甲基）丙烯酸［（3aR，6aβ，9aβ，9bα）-十二氢-8α-羟基-3，6，9-三亚甲基-2-氧代薁并［4，5-b］呋喃］-4β-基），其含量通常为约0.7质量％。
（B-4）迷迭香提取物
迷迭香提取物是迷迭香的提取物。迷迭香（rosemary）也叫海之朝露（マンネンロウ），学名Rosmarinus officinalis L.，是属于唇形科的常绿性灌木。迷迭香提取物可以是迷迭香的植物体整体以及一部分中的任意一个的提取物。提取物的制备条件没有特别的限定，溶剂，优选水、醇或者它们的组合，更优选水和乙醇的组合。
（B-5）异黄酮
异黄酮是3-苯基色原酮（3-苯基-4H-1-苯并吡喃-4-酮）。异黄酮优选从糖苷的形式中分离糖得到的苷元（异黄酮苷元）。异黄酮可以来源于天然产物，也可以是通过化学合成等的人工产物。
来源于天然产物的异黄酮可列举例如，大豆的提取物，其中优选发酵大豆的提取物（以下称为发酵大豆提取物）。发酵大豆是使微生物作用于大豆从而使大豆发酵得到的。发酵可以向大豆中添加菌类（例如曲霉）在该菌的最适发酵条件下进行。发酵大豆的提取物的制备条件没有特别的限定，作为溶剂，可列举例如醇。发酵大豆的提取物通常含有异黄酮30～40质量％。
（B-6）葡萄籽提取物
葡萄籽提取物是葡萄（葡萄科（Vitaceae）的藤性灌木）种子的提取物。提取物的提取对象是种子。葡萄籽提取物的制备条件没有特别的限定，作为溶剂，优选水、醇。使用水作为溶剂的情况下，优选葡萄籽在水中在70℃以上（优选80～120℃，更优选80～100℃）的提取温度范围下对葡萄籽进行提取。葡萄籽提取物中含有原花青素，其含量通常为约38质量％。
（B-7）松树皮提取物
松树皮提取物是松（松属（Pinus）的植物）树皮的提取物。作为松可例举辐射松（PinusRadiata）。提取物的制备条件没有特别的限定，作为溶剂优选水。松树皮提取物中含有原花青素、儿茶素、类黄酮等。
（B-8）毛喉鞘蕊花提取物
毛喉鞘蕊花提取物是毛喉鞘蕊花的植物体提取物。毛喉鞘蕊花是唇形科锦紫苏属的多年生草本，学名是Coleus Forskohlii、Coleus barbatus、Plectranthus Barbatus。毛喉鞘蕊花提取物可以是毛喉鞘蕊花的植物体的整体以及一部分中的任意一个的提取物。提取物的制备条件没有特别的限定。毛喉鞘蕊花提取物中含有作为二萜的一种的毛喉素。
（B-9）可可提取物
可可提取物是可可（梧桐科可可，学名Theobroma cacao）的提取物。可可提取物可以是可可植物体的整体以及一部分中的任一个的提取物，作为提取部位可列举例如果实（可可豆荚），种子，优选种子，更优选外壳皮（可可壳）。外壳皮是指，果实中的白色粘浆质的果肉包裹的可可豆（种子）周围的皮的意思。可可提取物的制备条件没有特别的限定，作为溶剂优选醇，更优选含水乙醇（例如乙醇50～80体积％的含水乙醇）。
可可提取物中含有可可碱（3，7-二甲基黄嘌呤），其含量通常为10质量％。此外，可可提取物中还含有多酚，其含量通常为约20质量％。可可提取物进一步地含有苯乙胺（2-苯乙胺）以及γ-氨基丁酸。
成分（B）是选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮、葡萄籽提取物、松树皮提取物、毛喉鞘蕊花提取物以及可可提取物组成的组中的1种以上即可，也可以是2种以上的组合。在2种以上的情况下，优选含有选自于毛喉鞘蕊花提取物、丛梗藻提取物以及迷迭香提取物组成的组中的1种或者2种以上的组合。更优选的组合如下：毛喉鞘蕊花提取物和丛梗藻提取物的组合；毛喉鞘蕊花提取物和迷迭香提取物的组合；丛梗藻提取物和迷迭香提取物的组合；毛喉鞘蕊花提取物、丛梗藻提取物和迷迭香提取物的组合。
成分（B）的混合量，以每日人的摄取量计，通常为0.01mg～50g/日，优选0.1mg～10g/日，更优选1mg～1,000mg/日。通过使其在此范围内，能得到促进脂肪分解效果显著优异的促进脂肪分解组合物。此外，该组合物的成本、安全性等的方面也没有问题。另外，成分（B）使用2种以上的情况下，2种类以上的合计混合量是上述成分（B）的混合量。
成分（A）和成分（B）的配比，以每日人的摄取量计，通常为10：1～1：10，优选5：1～1：5，更优选3：1～1：3。通过使其在此范围内，能得到促进脂肪分解效果显著优异的促进脂肪分解组合物。
本发明的促进脂肪分解组合物促进脂肪的分解。本发明中的促进脂肪分解是指，生体内的脂肪分解水平（速度、量等）比通常増加的意思。
对于本发明的促进脂肪分解组合物促进脂肪分解的确认，例如，如实施例所示的那样进行。即，对由大鼠肠系膜组织制备的前体脂肪细胞添加样品，进行甘油的定量。定量中可以使用甘油试剂盒（F）（F-kitGlycerol）（罗氏公司（ロシュ社）制，产品号码：14820）等的市售试剂盒（kit）。比较得到的甘油量和在没有添加样品的情况下的甘油量，量多的情况，可以确认其促进脂肪分解。
本发明的促进脂肪分解组合物的对象没有特别的限定。对人或者人以外的脊椎动物有用。与作为对象的人或者人以外的脊椎动物的健康状态也没关系。例如，适用于感觉到肥胖感的对象，希望减体重的对象，希望预防高血压、高血糖、高血脂症等的生活习惯病的对象。即使是对于没有特殊问题的对象也能够作为以促进脂肪分解为目的而日常摄取。
本发明的促进脂肪分解组合物，除作为有效成分的上述成分（A）以及（B）之外，还可以混合药学上允许的载体。作为药学上允许的载体可列举例如油性成分、润滑剂、赋形剂、粘合剂、崩解剂、包衣剂等。此外，可以适当、适量含有甜味剂、酸味剂、香味剂、着色剂、色素、成色剂、调味剂、抗氧化剂、防腐剂、产味剂、强化剂、维生素剂、膨胀剂、増粘剂、表面活性剂等的添加物、。
作为油性成分可举例各种脂肪酸酯、烃、高级脂肪酸。高级醇等。作为润滑剂可举例硬脂酸镁、硬脂酸、硬脂富马酸钠、蔗糖脂肪酸酯、聚乙二醇（Macrogol）、滑石粉等。
作为粘合剂可举例羟丙基纤维素、羟丙基甲基纤维素、甲基纤维素、明胶、淀粉、糊精、阿拉伯胶、海藻酸钠、黄蓍胶、精制明胶、聚乙烯醇、聚乙烯吡咯烷酮、甲基纤维素、聚乙烯醇（部分皂化物）、乙基纤维素、普鲁兰多糖（Pullulan）、聚乙二醇（Macrogol）等。
作为崩解剂可举例羧甲基纤维素钙（Carmellose Calcium）、羧甲基纤维素钠（Carmellose Sodium）、低取代度羟丙基纤维素、羧甲基纤维素、羧甲基淀粉钠、交联羧甲基纤维素钠（Croscarmellose Sodium）、粉末纤维素、纤维素或者他们的衍生物、交联聚乙烯吡咯烷酮（交联聚维酮Crospovidone）、淀粉、羧甲基淀粉、羟丙基淀粉、琼脂等。
作为赋形剂举例有下述化合物：
结晶纤维素，海藻酸钠，黄原胶等的多糖类；
α化淀粉、羟丙基淀粉、玉米淀粉、马铃薯淀粉等的淀粉以及其衍生物；
蔗糖、葡萄糖、木糖醇、赤藓糖醇、山梨糖醇、乳糖醇、海藻糖、帕拉金糖、异麦芽酮糖醇（还原帕拉金糖）、甘露糖醇、麦芽糖醇、乳糖醇、乳糖、果糖、粉末还原麦芽糖浆等的糖类以及糖醇类；
粉末纤维素、部分α化淀粉、乙基纤维素等的纤维素及其衍生物；
轻质无水硅酸、氧化钛、氢氧化铝凝胶、合成硅酸铝、三硅酸铝、二氧化硅、高岭土、可可脂、柠檬酸或其盐、硬脂酸或其盐、磷酸氢钙、磷酸氢钠。
作为甜味料可举例阿斯巴甜、安赛蜜钾、糖精钠、三氯蔗糖、甜叶菊、索马甜等。作为酸味料可举例柠檬酸、琥珀酸、酒石酸、苹果酸、富马酸等。作为香味剂可举例薄荷脑、樟脑、冰片、柠檬烯等的单萜类，各种香料等。
本发明的促进脂肪分解组合物的给与形式没有特别的限定。可列举例如，经口给与（例如、口腔内给与、舌下给与等），非经口给与（静脈内给与、肌肉内给与、皮下给与、经皮给与、经鼻给与、经肺给与等）等。这其中优选侵袭性少的给与形式，更优选经口给与。
本发明的促进脂肪分解组合物的剂型，没有特别的限定，根据给与形式适宜选择。作为经口给与时的剂形的例子可列举液状（液剂）、糖浆状（糖浆剂）、片剂（片剂（Tablet）等）、胶囊状（胶囊剂）、粉末状（颗粒、细粒）、软胶囊状（软胶囊剂）、液状（液剂）、糖浆状（糖浆剂）、固体状、半液体状、膏状、糊状等。
促进脂肪分解组合物的制造方法没有特别的限定，可以适当选择使之与剂型相符。例如剂型为片剂的情况下，可列举混合乳铁蛋白以及根据需要混合的任意成分后，将得到的混合物压缩成形从而得到片剂的方法，进一步地用肠溶性成分对如上所述的压缩成形得到的片剂进行包衣的方法（作成肠溶剂的方法），优选后者的方法。作为肠溶性成分可列举虫胶、羟甲基纤维素邻苯二甲酸酯、羧甲基纤维素、氨基烷基甲基丙烯酸酯共聚物、啤酒酵母细胞壁（例如、商品名イーストラップ等）、木薯淀粉、明胶、果胶，其中优选虫胶。另外，可以通过第14次修改的日本药局方崩解试验法确认是否是肠溶剂。
本发明的促进脂肪分解组合物显示了对于脂肪分解的优异的促进效果。因而，对于肥胖的预防、治疗是有效。根据本发明的促进脂肪分解组合物，可以期待减少内脏脂肪的效果，因而可以期待有效地预防、治疗高血压、高血糖、高血脂症等的生活习惯病。
经口给与情况下的给与方法可以根据成分（A）以及（B）的各个混合浓度、剂型、给与对象的年齢、体重、性別、运动前服用的情况下运动的负荷等的条件适当确定。例如剂型为片剂的情况下，优选与水等一起服用。给与间隔可以适当确定，饭前、饭后、以及吃饭时中的任意一个都可以。
另外，除给与本发明的促进脂肪分解组合物之外，也可以组合给与1种或者2种以上的其他的促进脂肪分解剂或者组合物。或者作为本发明的促进脂肪分解组合物可以作成为如下形式的组合物：除成分（A）以及（B）的组合以外，也含有1种或者2种以上其他的具有促进脂肪分解效果的成分。
通过给与人或者人以外的脊椎动物促进脂肪分解组合物，能够促进脂肪的分解。因而本发明的促进脂肪分解剂作为医药、医药部外品、食品、饲料也是有用的。
食品通常是加工食品，可列举例如，饮料（清凉饮料，碳酸饮料，营养饮料，粉末饮料，果汁饮料，乳饮料，果冻饮料等），点心类（饼干、蛋糕、口香糖、糖果、片剂、软糖、馒头、羊羹、布丁、果冻、冰激凌、果子露等），水产加工品（鱼糕、筒状鱼卷、鱼肉山芋饼（はんぺん）等），畜牧加工品（汉堡、火腿、腊肠（sausage）、牛肉熏香肠（wiener）、奶酪、黄油、酸奶、生奶油、奶酪、人造奶油（Margarine），发酵乳等），汤（粉末状汤、液状汤等），主食类（米饭类，面（挂面（乾麺）、生面（生麺））、面包、谷类食品等），调味料（蛋黄酱、起酥油、色拉调料汁、辣酱油（sauce）、烧烤汁（たれ）、酱油等）。进一步地本发明的促进脂肪分解剂可以是例如健康食品、功能性食品、保健功能食品、特定保健用食品、营养功能食品、营养补助食品（Supplement）、医疗用食品、病患用食品，婴儿用食品、护理用食品、老年人用食品等。
在此含有促进脂肪分解组合物的食品的摄取时期没有特别的限定。例如，可以在饭前饭后摄取，也可以在运动前后摄取。
作为食品的情况下，优选表现出本发明效果的。作为本发明效果的表现表示可列举例如，表现出促进脂肪分解使用的目的。
像这样，本发明的促进脂肪分解组合物，通过作为食品给与人被摄取，促进体内脂肪的分解。因而，本发明的食品作为防止肥胖用、减体重用、预防生活习惯病用等的各种食品是有用的。
本发明的促进脂肪分解组合物，即使是给与人以外的脊椎动物（例如宠物）也可以期待促进体内脂肪的分解的效果，因而作为饲料也是有用的。
进一步地，本发明的促进脂肪分解组合物的成分（A）以及（B），通过添加到通常的食品或者饲料，可以赋予该食品或者饲料促进脂肪分解效果。
实施例
以下，基于实施例详细说明本发明。另外，本发明并不限定于这些实施例。
实验例1～9以及比较实验例1～4
·大鼠肠系膜脂肪细胞的制备
使用2只SD大鼠（雄性，10周龄，日本SLC株式会社（日本エスエルシー株））。在醚麻醉下使大鼠安乐死，解剖，取出肠系膜脂肪组织。将取出的组织放入灭菌的培养皿，浸入添加了1％的抗生素（Antibiotic-Antimycotic Stabilized，西格玛株式会社（シグマ社）制，A5955）的冰镇的生理盐水（大塚生食注，大塚制药株式会社）中，洗涤血液以及毛（换溶液洗涤数次，直到看不到毛），除去淋巴。用眼科剪刀切断组织（每1g组织切断25次），用添加1mg/mL的胶原蛋白酶（来源于放射菌的Collagenase S-1，新田明胶（新田ゼラチン）株式会社）的PBS溶液，37℃40分钟，每隔数分钟就边搅拌边分散组织。作为标准，1只份的组织用20mL胶原蛋白酶溶液处理。
用100μm孔径的细胞过滤器（BDFalcon公司制，REF352360）过滤后，分别添加20mL DMEM（Dulbecco’s Modified Eagle’s Medium-high glucose，西格玛株式会社制，D5796）从而使液体的粘性下降，以800rpm离心分离10分钟。用吸引器除去上层的油层后，再次使其悬浊，用70μm孔径的细胞过滤器（BD Falcon公司制，REF352350）过滤。以800rpm离心15分钟，确认颗粒以及上清液中没有浮游细胞并除去上清液。分别用5mLDMEM（无血清）使沉淀悬浊，800rpm离心15分钟除去上清液。
得到的沉淀物静静地在5mL的内脏脂肪分化用培养基（Visceral AdipocyteCulture Medium250mL，Primary Cell株式会社（プライマリーセル株式会社）制，code：VACMR）中悬浊。稀释10倍计算细胞数结果浓度为1.015×107个细胞/mL。从1只大鼠能够回收2.54×107个细胞。以6×106个细胞/24孔格的方式，分别在培养基以500μL/孔格开始培养。第二天，添加500μL培养基，每2日进行培养基交换。之后，每隔1日交换培养基，开始6日后交换含有各种样品的培养基。添加48小时后回收培养的上清液，结束培养。通过目视确认全部的培养中没有细胞损害性。
·样品的制备
制备各实验例以及比较实验例使用的样品。作为样品的成分使用乳铁蛋白（DMV制），覆盆子酮（高砂香料工业株式会社制）、洋蓟叶提取物（一丸自然美健株式会社（ファルコス株式会社）制，商品名バイオベネフィティF）、可可提取物（Oryza油化株式会社（オリザ油化）制，可可提取物-P）、葡萄籽提取物（龟甲万株式会社（キッコーマン株式会社）制，商品名グラヴィノール）、松树皮提取物（Enzo Nutraceuticals Limited制，商品名Enzogenol（エンゾジノール））、毛喉鞘蕊花提取物（Natural Remedie社制）、丛梗藻提取物、迷迭香提取物（狮王株式会社制，商品名レオミール）、大豆异黄酮苷元（龟甲万株式会社制），生姜提取物（日本粉末药品株式会社制）、表没食子儿茶素没食子酸酯（和光纯药工业株式会社制）、绿原酸（和光纯药工业株式会社制）。作为洋蓟叶提取物使用的バイオベネフィティF含有作为赋形剂的糊精70质量％，表1所示的洋蓟叶提取物的混合量是除去该赋形剂从而换算出的数値。
丛梗藻提取物在以下的条件下提取。丛梗藻干燥物10g在20倍量的含水乙醇（醇/水＝30/70（V/V））中搅拌3小时，将其上清液蒸馏除去溶剂从而得到丛梗藻提取物。
将乳铁蛋白的浓度调整到30ppm以及10ppm，以各自的浓度作为单独评价用样品（比较实验例1）。乳铁蛋白以外的各成分如下述作为单独评价用样品使用。此外，将乳铁蛋白以外的各成分和乳铁蛋白分别调整到下述浓度混合，作为复合评价用的样品使用（实验例1～9以及比较实验例2～4）。
（单独评价用的样品）
·乳铁蛋白以外的各成分30ppm
·乳铁蛋白以外的各成分10ppm
（复合评价用的样品（＋乳铁蛋白30ppm））
·乳铁蛋白以外的各成分30ppm＋乳铁蛋白30ppm
·乳铁蛋白以外的各成分10ppm＋乳铁蛋白30ppm
（复合评价用的样品（＋乳铁蛋白10ppm））
·乳铁蛋白以外的各成分30ppm＋乳铁蛋白10ppm
·乳铁蛋白以外的各成分10ppm＋乳铁蛋白10ppm
·甘油浓度的定量
甘油的定量用甘油试剂盒（F）（罗氏公司制，产品号码：14820）进行。吸光度的测定用Novaspec Plus（Amersham Bioscience公司制）进行。向蒸馏水11mL中加入溶解的溶液I1.0mL、蒸馏水2.0mL、上述的各样品0.1mL、溶液II0.01mL。充分混合，室温下反应5分钟，测定AB340mm的吸光度（E1）。向其中加入溶液III0.01mL，充分混合。室温下反应7分钟，测定吸光度（E2）。标准液使用试剂盒中附带的标准液。
基于测定的吸光度按照附带的操作说明书，用以下的计算式1计算甘油浓度。
（计算式1）
甘油[g/L]＝
V×MW/ε×d×v×1000×δE×稀释率
δE＝（E2-E1）样品-（E2-E1）空白
V（反应液量）：3.02mL
MW（分子量）：92.1
d（光路长度）：1cm
ε（吸光系数）：6.3（1×mmol-1×cm-1）
v（检测量）：0.1mL
（基于计算式1算出甘油浓度）
甘油［g/L］
＝3.02×92.1/6.3×1×0.1×1000×δE
＝0.441×δE×稀释率
算出各实验例以及比较例的甘油量以无添加组的甘油量为0％时的相对値（％），该相对値作为促进脂肪分解率记于表中。各实验例以及比较实验例的促进脂肪分解率显示于表1-1（单独评价）、表1-2（复合评价（与乳铁蛋白30ppm的组合））、表1-3（复合评价（与乳铁蛋白10ppm的组合））。
＜结果＞
如表1所示，实验例1～9中的复合评价的促进脂肪分解率，超过了各成分浓度相当的单独评价的促进脂肪分解率的总和。
例如，实验例9的复合评价（异黄酮10ppm＋乳铁蛋白10ppm：表1-3）的促进脂肪分解率32％超过了比较实验例1的乳铁蛋白10ppm的单独评价的促进脂肪分解率12.1％（表1-1）和实验例9异黄酮10ppm的单独评价的促进脂肪分解率0％相加的数值。举其他的例子，覆盆子酮（实验例1）以及松树皮提取物（实验例5），各自10ppm的单独评价索性是阻碍脂肪分解，但是分别组合乳铁蛋白10ppm的情况下，比单独的乳铁蛋白10ppm的情况下也优异，显示出预测不到的促进分解的效果（表1-3）。
另一方面，比较实验例2的各复合评价的促进脂肪分解率，低于比较实验例2的单独评价的促进脂肪分解率和比较实验例1的单独评价的促进脂肪分解率的相加的数値。比较实验例3以及4中也不能看到如同实验例1～9的显著的协同效果。
这些结果显示了通过组合本发明中的成分（A）和成分（B）能发挥协同效果，发挥预测不到的显著的促进脂肪分解作用。
[表1-1]促进脂肪分解率（单独评价）
[表1-2]促进脂肪分解率（复合评价（＋乳铁蛋白30ppm））
[表1-3]促进脂肪分解率（复合评价（＋乳铁蛋白10ppm））
实验例10～13以及比较实验例5～7
作为样品除了使用表2中所示的组合之外，与实验例1同样地进行促进脂肪分解率的评价。结果显示于表2。
从表2可以明确地知道，实验例10～13的促进脂肪分解率，远超过构成各实验例的各成分的单独评价的促进脂肪分解率（表1-1参照）相加的数值。而比较实验例5～7的促进脂肪分解率低于构成各实验例的各成分的单独评价的促进脂肪分解率（表1-1参照）的相加的数值。
这些结果显示了，本发明的组合物中成分（B）即使是2种以上的组合，也与成分（B）是1种的情况相同，能发挥成分（A）以及成分（B）的协同效果，发挥预测不到的显著的促进脂肪分解作用。
[表2]促进脂肪分解率
Claims (3)
1.一种促进脂肪分解组合物，其含有(A)乳铁蛋白和
(B)可可提取物、或者可可提取物与选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮以及毛喉鞘蕊花提取物所组成的组中的1种以上的组合的成分，
所述成分(A)和所述成分(B)的配比为1：3～3：1。
2.如权利要求1中所述的促进脂肪分解组合物，其是食品、饲料或者药品。
3.一种将促进脂肪分解的效果赋予食品或者饲料的方法，向食品或者饲料中添加
(A)乳铁蛋白和
(B)可可提取物、或者可可提取物与选自于丛梗藻提取物、覆盆子酮、洋蓟叶提取物、迷迭香提取物、异黄酮以及毛喉鞘蕊花提取物所组成的组中的1种以上的组合的成分，
所述成分(A)和所述成分(B)的配比为1：3～3：1。
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| CN107302997A (zh) * | 2016-04-19 | 2017-10-31 | 林秀霞 | 一种抑制脂肪蓄积的组合物及其用途 |
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| JP6841444B2 (ja) * | 2019-06-04 | 2021-03-10 | 株式会社東洋新薬 | 免疫賦活剤 |
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| CN103327999A (zh) | 2013-09-25 |
| KR20150023884A (ko) | 2015-03-05 |
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| JP2015205913A (ja) | 2015-11-19 |
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