CN103314295B - Bubr1作为药物对呋咱并苯并咪唑响应的生物标记的用途 - Google Patents

Bubr1作为药物对呋咱并苯并咪唑响应的生物标记的用途 Download PDF

Info

Publication number
CN103314295B
CN103314295B CN201280005583.6A CN201280005583A CN103314295B CN 103314295 B CN103314295 B CN 103314295B CN 201280005583 A CN201280005583 A CN 201280005583A CN 103314295 B CN103314295 B CN 103314295B
Authority
CN
China
Prior art keywords
bubr1
cancer
purposes according
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280005583.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN103314295A (zh
Inventor
H·A·雷恩
F·巴赫曼
M·布勒勒
M·布特罗斯
D·吉尔伯特
张闲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of CN103314295A publication Critical patent/CN103314295A/zh
Application granted granted Critical
Publication of CN103314295B publication Critical patent/CN103314295B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
CN201280005583.6A 2011-01-21 2012-01-19 Bubr1作为药物对呋咱并苯并咪唑响应的生物标记的用途 Expired - Fee Related CN103314295B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11151677.9 2011-01-21
EP11151677 2011-01-21
PCT/EP2012/050818 WO2012098207A1 (en) 2011-01-21 2012-01-19 Use of bubr1 as a biomarker of drug response to furazanobenzimidazoles

Publications (2)

Publication Number Publication Date
CN103314295A CN103314295A (zh) 2013-09-18
CN103314295B true CN103314295B (zh) 2016-03-16

Family

ID=43920866

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280005583.6A Expired - Fee Related CN103314295B (zh) 2011-01-21 2012-01-19 Bubr1作为药物对呋咱并苯并咪唑响应的生物标记的用途

Country Status (12)

Country Link
US (2) US10222377B2 (https=)
EP (1) EP2666016B1 (https=)
JP (1) JP6302673B2 (https=)
CN (1) CN103314295B (https=)
AU (1) AU2012208520B2 (https=)
CA (2) CA2822491C (https=)
DK (1) DK2666016T3 (https=)
ES (1) ES2620582T3 (https=)
HU (1) HUE032643T2 (https=)
PL (1) PL2666016T3 (https=)
PT (1) PT2666016T (https=)
WO (1) WO2012098207A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2691533B1 (en) * 2011-03-29 2017-04-05 Basilea Pharmaceutica AG Use of phospho-akt as a biomarker of drug response
WO2015173341A1 (en) * 2014-05-13 2015-11-19 Basilea Pharmaceutica Ag Dosage principle for anti-cancer furazanylbenzimidazoles
WO2017068182A1 (en) 2015-10-22 2017-04-27 Basilea Pharmaceutica Ag Use of eb1 as a biomarker of drug response
MX2021011775A (es) 2017-04-26 2023-01-10 Basilea Pharm Int Ag Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.
US11633383B2 (en) 2017-05-16 2023-04-25 Basilea Pharmaceutica International AG Dosage principle for drugs useful for treating neoplastic diseases
CN107119137B (zh) * 2017-05-26 2018-04-06 广州华弘生物科技有限公司 一种快速检测HER‑2/neu基因表达的检测试剂盒
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
WO2022053549A1 (en) 2020-09-10 2022-03-17 Basilea Pharmaceutica International AG Use of c-myc as a biomarker of drug response

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1492875A (zh) * 2001-02-21 2004-04-28 ϣ 用于诊断和作为癌症治疗靶标的ttk
WO2005020794A2 (en) * 2003-08-25 2005-03-10 Board Of Regents, The University Of Texas System Taxane chemosensitivity prediction test
CN1753889A (zh) * 2002-12-24 2006-03-29 阿斯利康(瑞典)有限公司 喹唑啉化合物
CN1812986A (zh) * 2003-05-23 2006-08-02 巴斯利尔药物股份公司 呋咱并苯并咪唑类化合物
CN101072883A (zh) * 2004-12-08 2007-11-14 安万特药物公司 测量对多西他赛抗药性或敏感性的方法
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489137B2 (en) * 1997-06-11 2002-12-03 Chiron Corporation Detection of loss of the wild-type huBUB1 gene
AU1614099A (en) 1997-12-01 1999-06-16 Fox Chase Cancer Center Novel genes encoding proteins involved in mitotic checkpoint control and methodsof use thereof
US8021831B2 (en) * 2003-08-25 2011-09-20 Board Of Regents, The University Of Texas System Taxane chemosensitivity prediction test
JP2009173629A (ja) * 2007-12-21 2009-08-06 Banyu Pharmaceut Co Ltd Ｒｓｋ１阻害作用を有する新規スピロインダン誘導体
UA106763C2 (uk) * 2009-07-27 2014-10-10 Базілеа Фармас'Ютіка Аг Фуразанобензимідазоли як проліки для лікування пухлинних або аутоімунних захворювань

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1492875A (zh) * 2001-02-21 2004-04-28 ϣ 用于诊断和作为癌症治疗靶标的ttk
CN1753889A (zh) * 2002-12-24 2006-03-29 阿斯利康(瑞典)有限公司 喹唑啉化合物
CN1812986A (zh) * 2003-05-23 2006-08-02 巴斯利尔药物股份公司 呋咱并苯并咪唑类化合物
WO2005020794A2 (en) * 2003-08-25 2005-03-10 Board Of Regents, The University Of Texas System Taxane chemosensitivity prediction test
CN101072883A (zh) * 2004-12-08 2007-11-14 安万特药物公司 测量对多西他赛抗药性或敏感性的方法
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAL27862: A unique microtubule-targeted drug that suppresses microtubule dynamics, severs microtubules, and overcomes BcI-2-and tubulin subtype-related drug resistance;ESTEVE MARIE-ANNE ET AL.;《101ST ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH》;20100417;第51卷;1-2 *

Also Published As

Publication number Publication date
CA3142576A1 (en) 2012-07-26
ES2620582T3 (es) 2017-06-29
JP6302673B2 (ja) 2018-03-28
JP2014505877A (ja) 2014-03-06
HUE032643T2 (en) 2017-10-30
US20160320397A1 (en) 2016-11-03
US20140045897A1 (en) 2014-02-13
AU2012208520B2 (en) 2016-03-10
US9970938B2 (en) 2018-05-15
CA2822491C (en) 2023-02-14
EP2666016B1 (en) 2017-01-04
PL2666016T3 (pl) 2017-07-31
DK2666016T3 (en) 2017-04-10
NZ611805A (en) 2015-05-29
HK1189056A1 (zh) 2014-05-23
WO2012098207A1 (en) 2012-07-26
CA2822491A1 (en) 2012-07-26
AU2012208520A1 (en) 2013-07-04
US10222377B2 (en) 2019-03-05
PT2666016T (pt) 2017-04-03
CN103314295A (zh) 2013-09-18
EP2666016A1 (en) 2013-11-27

Similar Documents

Publication Publication Date Title
CN103314295B (zh) Bubr1作为药物对呋咱并苯并咪唑响应的生物标记的用途
CN103392130B (zh) 乙酰化微管蛋白作为对呋咱并苯并咪唑类的药物反应的生物标志物的用途
CN103460042B (zh) Glu-微管蛋白作为对呋咱并苯并咪唑类的药物反应的生物标志物的用途
CN103328978B (zh) stathmin作为呋咱并苯并咪唑类药物应答的生物标记的用途
CN103502467A (zh) 磷酸化-Akt作为药物响应的生物标志物的用途
HK1189056B (en) Use of bubr1 as a biomarker of drug response to furazanobenzimidazoles
AU2012208521B9 (en) Use of stathmin as a biomarker of drug response to furazanobenzimidazoles
HK1191096B (en) Use of acetylated tubulin as a biomarker of drug response to furazanobenzimidazoles
HK1192323B (en) Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles
NZ611805B2 (en) Use of bubr1 as a biomarker of drug response to furazanobenzimidazoles
HK1185947B (en) Use of stathmin as a biomarker of drug response to furazanobenzimidazoles
HK1189633A (en) Use of phospho-akt as a biomarker of drug response
HK1189633B (en) Use of phospho-akt as a biomarker of drug response

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1189056

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1189056

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160316