CN103285218A - Traditional Chinese medicine compound for treating spleen and kidney yang deficiency type constipation - Google Patents
Traditional Chinese medicine compound for treating spleen and kidney yang deficiency type constipation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound for treating spleen and kidney yang deficiency type constipation. The compound is prepared from the following raw materials in parts by weight: 20-40 parts of desertliving cistanche, 20-40 parts of herba epimedii, 6-12 parts of cinnamon, 10-20 parts of ginger processed pinellia, 10-20 parts of cortex magnoliae officinalis, 20-40 parts of allium macrostemon, 20-40 parts of kudzu root, 20-40 parts of tuckahoe and 30-60 parts of angelica. The traditional Chinese medicine compound provided by the invention is prepared according to traditional Chinese medicine theory and pathogenesis of spleen and kidney yang deficiency type constipation, the proportions of the ingredients are scientific and reasonable, as shown in a clinic result, the effective rate of constipation patients is 88% after taking the traditional Chinese medicine compound provided by the invention for two treatment courses, the constipation symptom severity (Wexner grade) is greatly reduced, and the severe constipation proportion is greatly reduced; the living quality (PAC-QOL scale) of constipation patients before and after the treatment has great difference at four dimensions and various dimensions, thereby expressing an excellent treatment effect on the spleen and kidney yang deficiency type constipation, and as shown in experimental investigation, the traditional Chinese medicine compound is free of untoward effects and is safe and effective in clinical use.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound, be specifically related to a kind of Chinese medicine compound and application thereof with the constipation for the treatment of yang deficiency of spleen and stomache, belong to the Chinese medicine preparation technical field.
Background technology:
Along with modern life rhythm is accelerated, dietary structure changes, aging and spiritual psychology and the society factors of social population, the sickness rate of functional constipation rises year by year, has become one of common disease of the modern people of influence quality of life.China's general crowd's functional constipation prevalence is 6%, and adult female's prevalence reaches 12.8%, and with advancing age, prevalence obviously increases; A Study of evidence based medicine report in the whole world, the overall sickness rate of constipation is 0.7%～79.0%, average 16%.Because the misery during defecation is to having a strong impact on that patients ' life quality causes, and all kinds of diet products are in vogue, the phenomenon of outpatient service abuse cathartic (mostly being the anthraquinone class) is particularly general, account for more than 70% of chronic constipation patient, this type of cathartic dependency constipation, " yang deficiency constipation " category in many genus traditional Chinese medical science " constipation " has caused bigger influence to people's life.Chinese medicine is having its unique advantage aspect anti-the treating constipation, and is therefore necessary under the guidance of theory of Chinese medical science, studies a kind of safety of taking, and toxic and side effects is little, has the Chinese medicine compound of good treatment yang deficiency of spleen and stomache constipation.
Summary of the invention:
Goal of the invention: technical problem to be solved by this invention is to overcome the deficiencies in the prior art, provides a kind of side effect little, has the Chinese medicine compound of fine treatment yang deficiency of spleen and stomache constipation.
Technical scheme: in order to realize above purpose, the technical scheme that the present invention takes is:
A kind of Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache, it is to be made by the raw material of following parts by weight:
20 to 40 parts of Herba Cistanches, 20 to 40 parts of Herba Epimedii, 6 to 12 parts of Cortex Cinnamomis, 10 to 20 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 to 20 parts of Cortex Magnoliae Officinalis, 20 to 40 parts of Bulbus Allii Macrostemonis, 20 to 40 parts of Radix Puerariaes, 20 to 40 parts in Poria, 30 to 60 parts of Radix Angelicae Sinensis.
As preferred version, above-described Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache, it is to be made by the raw material of following parts by weight:
20 parts of Herba Cistanches, 20 parts of Herba Epimedii, 6 parts of Cortex Cinnamomis, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 parts of Cortex Magnoliae Officinalis, 20 parts of Bulbus Allii Macrostemonis, 20 parts of Radix Puerariaes, 20 parts in Poria, 30 parts of Radix Angelicae Sinensis.
The application of Chinese medicine compound in preparation treatment yang deficiency of spleen and stomache constipation medicine with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention.
As preferred version, the present invention's handle has the Chinese medicine compound extract for the treatment of yang deficiency of spleen and stomache constipation and the medicine that pharmaceutically acceptable carrier is made capsule, microcapsule, tablet, granule, drop pill, suppository or oral liquid formulation.
The Chinese medicine compound extract can be prepared by following method: with Herba Cistanches, Herba Epimedii, Cortex Cinnamomi, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Cortex Magnoliae Officinalis, Bulbus Allii Macrostemonis, Radix Puerariae, Poria and Radix Angelicae Sinensis mix by weight proportion the back adopt decocting to boil or alcohol reflux after, concentrate and obtain extract.
When the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention is made tablet, the extract of Chinese medicine compound and carrier lactose or corn starch, add magnesium stearate lubricant when needing, mix homogeneously, tabletting is made tablet then.
When the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention is made capsule, the extract of Chinese medicine compound and carrier lactose or corn starch mix homogeneously, granulate, the encapsulated capsule of making then.
When the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention is made granule, the extract of Chinese medicine compound and diluent lactose or corn starch mix homogeneously, granulate, drying is made granule.
When the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention is made oral liquid, the extract of the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache is added water and the cosolvent dissolving, add syrup and prepare oral liquid.
The present invention, forms by a large amount of experiment screening Chinese medicine compound according to the Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to the pathogenesis of yang deficiency of spleen and stomache constipation patient.In the Chinese medicine compound, the sweet and tepor of Herba Cistanches, salty and matter profit, its power is gentle, and temperature and not hot is mended and not high, warm and not dry, and is sliding and do not let out.Characteristics with " with the body of tonic, making the usefulness of cathartic ".The hot temperature of Herba Epimedii, reinforcing the kidney and supporting YANG, but and tonneau urine.Two medicines share and are monarch drug altogether, can temperature lead to kidney yang, again can the intestine moistening purging FU-organs.
The hot temperature of Bulbus Allii Macrostemonis is unobstructed in the compound recipe, kind loose to stop up stagnate, on can declare the stasis of loosing lung qi, but in the yang-energy held back of Xuan Tongyu; Matter profit hardship is fallen, and can descend to lead to the YIN-cold of severe and lingering illness again.Say as " book on Chinese herbal medicine is looked for the truth ": " acrid in the mouth then looses, and is diffusing then can make cold stagnant standing and disappear; Bitter in the mouth then falls, and falls cold the stagnating of infra made; Temperature then looses, and is diffusing then can make to stagnate to stand in invasion by pathogenic cold and remove; Body is sliding then logical, and general rule can make for a long time chronic cold upright solution that stagnate.Real ventilation, sliding key, supporing yang good merchantable brand are also.”
The hot sweet cold of Radix Puerariae in the compound recipe and moistening, makings lightly floats, and disperses positive bright ailment said due to cold or exposure, rises clearing heat in QI system in the stomach, inspires in the stomach clearing heat in QI system up to fail body fluid; Can draw sweet using warming therapy medicine again and rise, with the insufficiency of primordial QI person, with this yang invigorating in the moon.
Cortex Magnoliae Officinalis, Rhizoma Pinelliae compatibility can activate yang by warming the stomach in the compound recipe, fall the stomach therapeutic method to keep the adverse QI flowing downwards; With Radix Puerariae phase 5, reside the lucid yang sending up among the turbid descending, mutual causality of ascending and descending, burnt mechanism of qi in smooth the accent.
Poria is sweet flat in the compound recipe, and light wet diuretic is let out turbid activating yang, to help the logical middle-jiao yang, function of the spleen and stomach of Bulbus Allii Macrostemonis a surname.Clear sun should rise, and turbid yin should fall, and positive wound must be illegally occupied by turbid yin, turbid yin checks the clear sun of mechanism of qi damage, so " it is turbid to desire to drive the moon, anxious activating yang ", Poria, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis three medicines share and can strengthen damp eliminating, let out turbid power in the compound recipe, lead foul descending to reach the turbid effect that activates yang of letting out.In letting out Jiao to stop the water in residences wet, smooth in the important department of burnt taste, important department turns round, ascending or descending movement of vital Qi is orderly, Yu Yang must stretch.
Cortex Cinnamomi acrid in the mouth perfume (or spice) in the compound recipe, the kind yang-energy that helps liver and gall, the network of the logical the moon of fainting of temperature; Extremely hot in nature is mended supporing yang, the conducting fire back to its origin of fire, the principal drug assistance temperature compensating below element.The sweet temperature of Radix Angelicae Sinensis, but merit blood-supplementing blood-nourishing, its property is glossy, and gas is light and hot, but also loosening bowel to relieve constipation.Reusing the Radix Angelicae Sinensis implied meaning in the side has three: one, compatibility Herba Cistanches, blood enriching and dryness moistening, supplementing fluid to relax the bowels, the power of enhancing relieving constipation.The two, the compatibility Cortex Cinnamomi, residence " control its positive person, must transfer its moon ", " kind YANG invigorating person must be in treating YANG within YIN, then positive cloudy helping and biochemical infinite ".The three, the compatibility Rhizoma Pinelliae, Bulbus Allii Macrostemonis, body that can the lung moistening gold, freely a surname of lung qi is respectful again; Four, the suffering of Rhizoma Pinelliae Preparata, Cortex Magnoliae Officinalis is dry, in case the fraud of yin-damaging and Qi consuming.
More than all medicines share, have the effect of good treatment deficiency of spleen-YANG and kidneyYANG constipation, and all medicines nurse one's health mutually, little to the body harmful effect, clinical practice is safer.
Beneficial effect: the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention is compared with prior art and is had the following advantages:
1, the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention, pathogenesis according to Chinese medical theory and yang deficiency of spleen and stomache constipation is chosen the material combination prescription, the each component proportioning is scientific and reasonable, clinical experiment is the result show, take Chinese medicine compound provided by the invention, constipation symptom severity (Wexner scoring) significantly reduces, and the ratio of serious constipation also has reduction by a relatively large margin.Constipation patient quality of life (PAC-QOL scale) has significant difference (P＜0.001) at four dimensions and each dimension before and after the treatment, after showing that the patient passes through compound of Chinese medicine provided by the invention, quality of life significantly improves, and the main tcm symptom of deficiency of spleen-YANG and kidneyYANG also obviously improves, show that patient's yang deficiency symptom improves, through Chinese medicine compound of the present invention after 2 courses for the treatment of the constipation patient effective percentage reach 88%, demonstrated the effect of good treatment deficiency of spleen-YANG and kidneyYANG constipation.And studies show that by long term test Chinese medicine compound provided by the invention is not seen untoward reaction, the clinical safety of taking.
2, the Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache provided by the invention can become the medicine of various dosage forms, convenient clinical use easily with pharmaceutically acceptable preparing carriers.
The specific embodiment:
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand that the described concrete material proportion of embodiment, process conditions and result thereof only are used for explanation the present invention, and should also can not limit the present invention described in detail in claims.
Embodiment 1
1, a kind of Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache, it is to be made by the raw material of following parts by weight:
20 parts of Herba Cistanches, 20 parts of Herba Epimedii, 6 parts of Cortex Cinnamomis, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 parts of Cortex Magnoliae Officinalis, 20 parts of Bulbus Allii Macrostemonis, 20 parts of Radix Puerariaes, 20 parts in Poria, 30 parts of Radix Angelicae Sinensis.
2, get the decocting that above 1 Chinese medicine compound adds 10 times of amounts and boil 2 times, each 2 hours, filter merging filtrate, concentrating under reduced pressure, get water extract, add medical starch, mix homogeneously adds water and makes soft material, crosses 20 mesh sieves and granulates, drying is made granule, incapsulates, and is prepared into capsule.
Embodiment 2
1, a kind of Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache, it is to be made by the raw material of following parts by weight:
40 parts of Herba Cistanches, 40 parts of Herba Epimedii, 12 parts of Cortex Cinnamomis, 20 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 20 parts of Cortex Magnoliae Officinalis, 40 parts of Bulbus Allii Macrostemonis, 40 parts of Radix Puerariaes, 40 parts in Poria, 60 parts of Radix Angelicae Sinensis.
2, get above 1 Chinese medicine compound, add 80% alcohol reflux 2 times of 8 times of amounts, each 2 hours, filter, merging filtrate, concentrating under reduced pressure gets extract, adds corn starch then, adds magnesium stearate lubricant, mix homogeneously, tabletting is made tablet then.
Embodiment 3
1, a kind of Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache, it is to be made by the raw material of following parts by weight:
30 parts of Herba Cistanches, 30 parts of Herba Epimedii, 10 parts of Cortex Cinnamomis, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 15 parts of Cortex Magnoliae Officinalis, 30 parts of Bulbus Allii Macrostemonis, 30 parts of Radix Puerariaes, 30 parts in Poria, 50 parts of Radix Angelicae Sinensis.
2, get above 1 Chinese medicine compound, the decocting that adds 10 times of amounts boils 3 times, and each 1 hour, filter, merging filtrate, concentrating under reduced pressure gets water extract, adds the diluent corn starch, mix homogeneously, granulate, drying is made granule.
Embodiment 4 clinical experimental studies
1.1 physical data
During in October, 2011～2012 year November, functional constipation patient 100 examples that the outpatient service of diagnosis and treatment center is gone to a doctor at the bottom of Nanjing Chinese Medicine Hospital's basin.Male patient's 22 examples, 61.05 ± 10.92 years old age, the course of disease (15.14 ± 14.94) year; Female patient 78 examples, 51.51 ± 14.04 years old age, the course of disease (16.67 ± 7.57) year.Wherein, account for 75.6% by the auxiliary defecation of irritant purgative.
1.2 diagnostic criteria
1.2.1 functional constipation diagnostic criteria
Adopt international functional gastrointestinal disease (FGIDS)-Rome III functional constipation (C3) diagnostic criteria: 1. must meet following binomial or more than the binomial: the defecation of a. at least 25% is felt effort; B. at least 25% defecation be the dry bulb shape just or firmly just; C. at least 25% defecation has sense not to the utmost; D. at least 25% defecation has anal orifice and rectal intestine sense of obstruction/obstruction sense; E. at least 25% defecation needs maneuver to help (as with supporting at the bottom of finger help defecation, the basin); F. defecation frequency＜3 time/week; 2. in situation following time of not using cathartic loose stool appears seldom; 3. there are not enough evidence diagnosis IBS.Symptom occurs at least 6 months before the diagnosis, and nearly 3 months symptoms meet above diagnostic criteria.
1.2.2 tcm syndrome diagnostic criteria
With reference to the chronic constipation Chinese traditional medical diagnose of the spleen-stomach disease branch of China Association of Traditional Chinese Medicine common recognition suggestion and State Administration of Traditional Chinese Medicine chronic slow-transit constipation tcm clinical practice path, diagnosis and treatment scheme.Syndrome of yang deficiency of spleen and kidney: excrement holds between intestinal, and it is difficult just to go out, and fear of cold is afraid of cold, and extremity are not warm, stomachache happiness temperature, and clear urine in large amounts, thist with desire to drink heat, the fat tongue of light red tongue is greasy in vain, deep-slow pulse.
1.3 the standard of including in
Meet functional constipation diagnostic criteria and Chinese medical discrimination standard (deficiency of spleen-YANG and kidneyYANG) person; 18～80 years old age; The signature Informed Consent Form.
1.4 exclusion standard
Because of following disease causer: 1. gastroenteropathy (intestinal nerve pathological changes, congenital megacolon, tumor etc.); 2. involve gastrointestinal systemic disease (hypothyroidism, diabetes, connective tissue disease, amyloid distortion, spinal cord injury, parkinson disease etc.); 3. medicine (opiate, spiritual class medicine, anticonvulsant, calcium-channel antagonists, anticholinergic etc.); 4. spirit or mental maladjustment (psychosis, depression, anorexia nervosa).Gestation or women breast-feeding their children; Allergic constitution reaches this medicine allergy; Not medication in accordance with regulations can't be judged the not congruent judgement person of affecting the treatment of curative effect or data.
2, method
2.1 Therapeutic Method
Give the Chinese medicine compound of the embodiment of the invention 1, divide clothes 2 times 1 dose of every day, 10 was 1 course for the treatment of, serve on 2 courses for the treatment of after observe the curative effect.
2.2 observation index
Go into to organize the patient if take cathartic in the recent period always, should carry out inactive cathartic (but but external glycerin or coloclysis the are auxiliary) back in a week and observe following index, as treating preceding investigation standard: the scoring of ⑴ constipation symptom severity: adopt the assessment of Wexner constipation marking scales; ⑵ quality of life marks: constipation patient quality of life questionnaire (PAC-QOL); ⑶ the scoring of traditional Chinese medical science cardinal symptom: the employing visual analogue scales (visual analogue scale, VAS).
2.3 therapeutic evaluation standard
Standard reference " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", cure: 2d is with interior defecation 1 time, just matter profit, defecation is unobstructed, does not have recurrence in a short time; Effectively: defecation is 1 time in the 3d, and just matter is changeed profit, and it is smooth that defecation is owed; Invalid: still need by irritant purgative or defecation frequency and just matter all do not have improvement.
2.4 safety assessment
During treating, if defecate not solution person on the 3rd, can suitably give glycerin or coloclysis and handle.
2.5 statistical method
Adopt the analysis of SPSS 17.0 statistical softwares.Carry out own control before and after all patient treatments, measurement data with
-x± s represents, two groups of relatively t checks of mean.Enumeration data χ
2Check or the accurate probability of Fisher carry out statistical disposition.
3, result
Through taking Chinese medicine compound provided by the invention, 100 routine patients cure 29 examples after 2 course of therapy, effective 59 examples, and invalid 12 examples, total effective rate is 88%.
3.1 constipation symptom severity scoring
Patient's constipation Wexner integral mean 18.73 ± 3.04(branch before the treatment), the patient of integration above 15 minutes accounts for 86%; Treatment back patient's constipation Wexner integral mean 6.48 ± 3.04(branch), the patient of integration above 15 minutes only accounts for 5%, demonstrated the effect of good treatment constipation.
3.2 the comparison of constipation doing well,improving situation before and after the treatment
The main tcm symptom of yang deficiency of spleen and stomache constipation, fear of cold is afraid of cold, extremity cold of the limbs, thirsty desire for hot drinks, and severity VAS scoring improvement rate is respectively 85.4%, 87.1%, 76.5% before and after the treatment.Wherein fear of cold be afraid of cold, extremity cold of the limbs, thirsty desire for hot drinks, severity VAS scoring improvement rate computational methods are before and after the treatment: before (before the treatment-treatment back)/treatment * 100%, result of the test shows, traditional Chinese medical science fear of cold is afraid of cold, the cardinal symptom scoring (employing visual analogue scales) of extremity cold of the limbs, thirsty desire for hot drinks, has demonstrated the effect of good treatment constipation.
3.3 treatment front and back each dimension integration of quality of life relatively
Each dimension of patient PAC-QOL and each dimension summation, before and after the treatment, difference all has statistical significance (P＜0.001).Concrete result of the test is as shown in table 1:
Compare before and after each dimension treatment of table 1 PAC-QOL [
X± s]
3.5 safety analysis
During treating, tangible untoward reaction does not all appear in all patients, shows that Chinese medicine compound security performance provided by the invention is good, easily applies.
The present invention according to the pathogeny of yang deficiency of spleen and stomache constipation, carries out scientific composition according to the Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has the effect of good treatment deficiency of spleen-YANG and kidneyYANG constipation through clinical and experimental study result proof, and does not occur untoward reaction in the experimentation.Therefore, Chinese medicine compound provided by the invention is expected to develop and becomes a new generation and treat the new drug of constipation safely and effectively.
Above embodiment only is explanation technical conceive of the present invention and characteristics; its purpose is to allow the people that is familiar with this technology understand content of the present invention and is implemented; can not limit protection scope of the present invention with this; all equivalences that spirit is done according to the present invention change or modify, and all should be encompassed in protection scope of the present invention.
Claims (4)
1. one kind has the Chinese medicine compound for the treatment of the yang deficiency of spleen and stomache constipation, it is characterized in that it is to be made by the raw material of following parts by weight:
20 to 40 parts of Herba Cistanches, 20 to 40 parts of Herba Epimedii, 6 to 12 parts of Cortex Cinnamomis, 10 to 20 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 to 20 parts of Cortex Magnoliae Officinalis, 20 to 40 parts of Bulbus Allii Macrostemonis, 20 to 40 parts of Radix Puerariaes, 20 to 40 parts in Poria, 30 to 60 parts of Radix Angelicae Sinensis.
2. the Chinese medicine compound with treatment yang deficiency of spleen and stomache constipation according to claim 1 is characterized in that it is to be made by the raw material of following parts by weight:
20 parts of Herba Cistanches, 20 parts of Herba Epimedii, 6 parts of Cortex Cinnamomis, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 10 parts of Cortex Magnoliae Officinalis, 20 parts of Bulbus Allii Macrostemonis, 20 parts of Radix Puerariaes, 20 parts in Poria, 30 parts of Radix Angelicae Sinensis.
3. claim 1 or the 2 described application of Chinese medicine compound in preparation treatment yang deficiency of spleen and stomache constipation medicine with the constipation for the treatment of yang deficiency of spleen and stomache.
4. the application of Chinese medicine compound in preparation treatment yang deficiency of spleen and stomache constipation medicine with the constipation for the treatment of yang deficiency of spleen and stomache according to claim 3 is characterized in that the medicine that a Chinese medicine compound with the constipation for the treatment of yang deficiency of spleen and stomache and pharmaceutically acceptable carrier are made capsule, microcapsule, tablet, granule, drop pill or oral liquid formulation.
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| CN105106539A (en) * | 2015-09-02 | 2015-12-02 | 宋琳 | Traditional Chinese medicine enema for treating yang deficiency type cancerous constipation and nursing method |
| CN105343226A (en) * | 2015-11-17 | 2016-02-24 | 康莉 | Traditional Chinese medicine composition for treating spleen and kidney insufficiency type constipation |
| CN113491251A (en) * | 2021-07-02 | 2021-10-12 | 山西中医药大学 | Kidney-yang deficiency type Parkinson disease rat model and preparation method thereof |
| CN114306465A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application |
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| CN102091152A (en) * | 2009-12-15 | 2011-06-15 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition with stomach-invigorating and digestion-promoting function and preparation method thereof |
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| CN105106539A (en) * | 2015-09-02 | 2015-12-02 | 宋琳 | Traditional Chinese medicine enema for treating yang deficiency type cancerous constipation and nursing method |
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| CN113491251A (en) * | 2021-07-02 | 2021-10-12 | 山西中医药大学 | Kidney-yang deficiency type Parkinson disease rat model and preparation method thereof |
| CN114306465A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application |
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| CN103285218B (en) | 2014-11-05 |
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