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Thrombectomy catheter systems

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Publication number
CN103251440A
CN103251440A CN 201310028600 CN201310028600A CN103251440A CN 103251440 A CN103251440 A CN 103251440A CN 201310028600 CN201310028600 CN 201310028600 CN 201310028600 A CN201310028600 A CN 201310028600A CN 103251440 A CN103251440 A CN 103251440A
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Prior art keywords
lumen
pressure
fluid
high
jet
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CN 201310028600
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Chinese (zh)
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CN103251440B (en )
Inventor
A·马希
D·赫顿
M·德什潘德
P·沙尔蒂斯
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科维蒂恩有限合伙公司
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/3203Fluid jet cutting instruments
    • A61B17/32037Fluid jet cutting instruments for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069Tip not integral with tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082Catheter tip comprising a tool

Abstract

A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.

Description

血栓切除术导管系统 Thrombectomy catheter system

[0001] 相关申请的交叉引用 CROSS [0001] REFERENCE TO RELATED APPLICATIONS

[0002] 本申请要求2012年I月26日提交的美国临时申请号N0.61/591,165的权益和优先权,其全部内容均以援引的方式并入本发明。 [0002] This application claims the benefit of US Provisional Application No. benefit and priority of May 26, 2012 I filed N0.61 / 591,165, the entire contents of which are incorporated herein by reference herein are.

技术领域 FIELD

[0003] 本公开涉及用于从血管内移除闭塞材料的系统,并且更加具体地涉及血栓切除术导管系统。 [0003] The present disclosure relates to a system for removing occluding material from within a vessel, and more particularly, to thrombectomy catheter system.

背景技术 Background technique

[0004] 业内已知用于从体腔中移除闭塞材料以保持体腔开放的设备。 [0004] known in the art for removing occluding material from the body cavity the body cavity to maintain the opening device. 这些设备可以是机械、电气或化学类型。 These devices can be mechanical, electrical or chemical type. 通常,每种类型的设备均特别适于从体腔中移除特定类型的闭塞材料,诸如,慢性凝块、亚急性凝块或急性凝块。 Typically, each type of apparatus are particularly suitable for removing certain types of occlusive material from a body cavity, such as clot chronic, acute or subacute clot clot. 例如,将化学药品注入到体腔中以从管腔中移除闭塞材料的设备在移除急性凝块中非常有效而在移除慢性凝块中效果则不明显。 For example, the chemical injected into the body cavity to remove material from the lumen occlusion device is very effective in the removal of the clot rather acute and chronic clot removal effect is not obvious.

[0005] 与设计用于从体腔中移除所有类型的闭塞材料的设备有关的一种困难在于制造一种如下装置:所述装置能够在最小化导致体腔受损的可能性的同时有效地移除闭塞材料。 [0005] and designed for removing from the body cavity blocking device about a difficult material to all types of apparatus is to produce one of the following: a device capable of effectively minimizing the possibility of shift results in damage to the body lumen while In addition to blocking material.

[0006] 因此,理想的是设置如下设备:所述设备能够在最小化导致体腔受损的风险的同时有效地从体腔中移除多种不同的闭塞材料。 [0006] Accordingly, it is desirable that the apparatus is provided as follows: the device can effectively remove a variety of different materials from the body cavity blocking minimizing the risk of damage to the body lumen simultaneously.

发明内容 SUMMARY

[0007] 本公开针对一种血栓切除术导管系统,所述血栓切除术导管系统包括血栓切除术导管,所述血栓切除术导管包括导管体并且包括高压管,所述导管体限定了排放管腔和注入管腔。 [0007] The present disclosure is directed to a thrombectomy catheter system, said system comprising thrombectomy catheter thrombectomy catheter, a thrombectomy catheter includes a catheter body and includes a high-pressure pipe, the exhaust lumen defining a catheter body and an injection lumen. 在一个方面中,高压管具有喷嘴喷口,所述喷嘴喷口定位成引导流体射流进入到排放管腔的远侧开口中。 In one aspect, the high-pressure pipe having a nozzle orifice, the nozzle orifice positioned to direct a jet of fluid into the distal opening of the exhaust lumen. 注入流体源与注入管腔的近端连通并且流体控制装置流体联接在血栓切除术导管和注入流体源之间。 Injecting the injection fluid source and a proximal end and a lumen in fluid communication with the control fluid coupling means between the thrombectomy catheter and a source of fluid injection. 流体控制装置适于调节从注入流体源注入至血栓切除术导管的注入管腔的注入流体的流速。 The fluid control means is adapted to adjust the injection fluid is injected from the source to the thrombectomy flow injection fluid injection lumen of the catheter.

[0008] 在血栓切除术导管系统的一个实施例中,注入流体和高压管中的流体是盐水。 [0008] In one embodiment thrombectomy catheter system, the injection fluid and high pressure fluid is a brine pipe.

[0009] 在另一个实施例中,血栓切除术导管系统包括高压管,所述高压管限定了位于高压管远端处的弯曲部分。 [0009] In this embodiment, the thrombectomy catheter system comprises a high pressure pipe, the high pressure tube defining a bent portion of the high pressure tube at the distal end in another embodiment. 喷嘴喷口定位在弯曲部分中,所述弯曲部分沿着基本横向于血栓切除术导管的纵向轴线的轴线延伸。 Nozzle orifices positioned in the curved portion, said curved portion extending along a substantially transverse to the thrombectomy catheter longitudinal axis of the axis.

[0010] 在另一个实施例中,血栓切除术导管系统包括与高压管连通的高压流体源。 [0010] In another embodiment, the thrombectomy catheter system comprises a high pressure fluid source in communication with the high pressure pipe. 高压流体源以大约IOOpsi和大约10,OOOpsi之间的压力将高压流体供应到高压管。 High pressure fluid source at a pressure between about IOOpsi and about 10, OOOpsi supplying high pressure fluid to the high pressure pipe.

[0011] 在另一个实施例中,血栓切除术导管系统包括基本上刚性的定位带,所述定位带固定到导管体的远端。 [0011] In another embodiment, the thrombectomy catheter positioning system comprises a substantially rigid band, the distal end of said positioning strap to the catheter body. 定位带限定了与导管体的排放管腔连通的排放管腔和与导管体的注入管腔连通的注入管腔。 Positioning the discharge belts define injection lumen and the discharge lumen lumen of the catheter body and communicating with the injection lumen of the catheter body in communication.

[0012] 在一个实施例中,高压管结合到定位带。 [0012] In one embodiment, the high-pressure pipe is coupled to the positioning belt. 高压管和定位带可以由金属或塑料形成。 High-pressure pipe and the positioning may be formed with a metal or plastic. [0013] 在一个实施例中,高压管延伸通过导管体和定位带的注入管腔。 [0013] In one embodiment, the high-pressure injection pipe extending through the catheter body lumen and positioning the belt.

[0014] 在一个实施例中,定位带的注入管腔限定了一对凹状部分,所述凹状部分的尺寸设计成接收高压管并且防止高压管相对于定位带横向运动。 [0014] In one embodiment, the injection zone defining a lumen positioning concave portions of the pair, the size of the concave portion is designed to receive a high pressure tube and the pressure pipe to prevent lateral movement relative to the positioning belt.

[0015] 在一个实施例中,定位带中的注入管腔毗邻定位带的排放管腔,并且覆盖至少140°的弧角。 [0015] In one embodiment, the injection lumen positioned with a lumen positioned adjacent the discharge zone, and covers an angle of at least 140 ° of arc.

[0016] 在另一个实施例中,设置了流体控制装置,所述流体控制装置包括可调节阀,所述可调节阀适于调节从注入流体源注入到血栓切除术导管的注入管腔中的流体流速。 [0016] In another embodiment, the fluid control device is provided, the fluid control means comprises an adjustable valve, the adjustable valve adapted to adjust the injection fluid is injected from the source to the implantation thrombectomy catheter lumen fluid flow rate.

[0017] 在一个实施例中,流体控制装置包括流体泵,所述流体泵用于将注入流体从注入流体源供应到血栓切除术导管。 [0017] In one embodiment, the fluid control device comprises a fluid pump, the fluid pump for injecting injection fluid from the fluid supply source to the thrombectomy catheter. 流体泵或可调节阀可以适于周期性改变供应到血栓切除术导管的注入流体的流速。 The fluid pump or an adjustable valve adapted to periodically vary the flow rate may be supplied to the injection fluid thrombectomy catheter.

[0018] 在另一个实施例中,血栓切除术导管包括防损伤尖端,所述防损伤尖端包括与定位带的注入管腔连通的一对注入通道和用于接收高压管的弯曲部分的贮存器。 [0018] embodiment, the thrombectomy catheter comprises an atraumatic tip, said atraumatic tip comprises a pair of positioning the injection lumen and the injection channel communicates with the reservoir and a curved portion for receiving the pressure pipe of another embodiment . 所述贮存器具有限定了切除窗口的上开口。 The reservoir having a cut defining a window opening.

[0019] 在另一个实施例中,注入通道延伸在高压管的弯曲部分的远侧延伸并且使得能够在尖端处纵向或横向注入注入流体。 [0019] In another embodiment, the injection passage extends distally extending portion of the curved tube and high pressure enables longitudinally or transversely injecting the injection fluid at the tip.

[0020] 在另一个实施例中,防损伤尖端具有微通道,以能够在中央腔和注入通道之间建立流体联接。 [0020] In another embodiment, the atraumatic tip has microchannels coupled to the fluid can be established between the central chamber and the injection channel. 微通道是位于将中央腔和注入通道分开的壁中的孔或者是由防损伤尖端的表面上的凹陷部形成的开放通道。 Microchannels are holes positioned to separate a central lumen and injection channel wall is formed by or atraumatic portion on the concave surface of the tip of the open channel.

[0021] 在另一个实施例中,血栓切除术导管系统包括引导导管,所述引导导管限定了:弓丨导管腔,所述引导管腔的尺寸设计成接收血栓切除术导管;近侧球囊和远侧球囊。 The proximal ball; Shu bow catheter lumen, the lumen size of the guide is designed to receive thrombectomy catheter: [0021] embodiment, the thrombectomy catheter system includes a guide catheter, said guide catheter defines a further embodiment of the capsule and a distal balloon.

[0022] 在另一个实施例中, 引导导管的位于近侧球囊和远侧球囊之间的部分具有正弦形状并且限定了多个开口,所述开口使得能够将闭塞材料吸入到血栓切除术导管中。 [0022] In another embodiment, the portion between the guide catheter and a distal balloon positioned proximal balloon has a sinusoidal shape and defines a plurality of openings so that the material can be drawn into the occluding thrombectomy catheter.

[0023] 在又一个实施例中,血栓切除术导管系统可以包括引导导管的位于近侧球囊和远侧球囊之间的部分,所述部分具有柔性并且限定了多个开口,所述开口使得能够将闭塞材料从血管吸入与血栓切除术导管相接触。 [0023] In yet another embodiment, the thrombectomy catheter system may include a balloon portion between the proximal and distal balloon guide catheter, having a flexible portion and defining a plurality of openings enabling the occlusive material from the blood vessel into contact with the suction thrombectomy catheter. 引导导管的所述部分的柔性使得一旦将血栓切除术导管插入到引导导管中之后引导导管便呈现出赋予血栓切除术导管的正弦形状,从而引导导管随后成正弦状。 After the flexible portion of the guide catheter such that once the thrombectomy catheter into the guide catheter guide catheter will exhibit a sinusoidal shape imparting thrombectomy catheter, a guide catheter so that subsequent to sinusoidal.

[0024] 在一个实施例中,定位传感器,以测量体腔内的压力。 [0024] In one embodiment, the positioning sensor to measure the pressure within the body cavity. 传感器可以连接到流体控制装置,以控制流体控制装置的操作。 Sensor may be connected to the fluid control device to control the operation of the fluid control apparatus.

[0025] 在一个实施例中,再循环通道定位成使得流体从排放管腔内再循环回到体腔中。 [0025] In one embodiment, the recirculation passage is positioned such that fluid discharged from the inner lumen of recycled back into the body cavity. 可以将过滤器定位在再循环通道的上游处,所述过滤器的尺寸设计成防止固体颗粒进入到再循环通道中。 The filter may be positioned upstream of the recirculation passage, the filter is sized to prevent solid particles from entering into the recirculation passage.

[0026] 在一个实施例中,排放管腔被分隔壁分成第一排放管腔和第二排放管腔,并且过滤器和再循环通道定位在第一排放管腔中。 [0026] In one embodiment, the exhaust lumen wall is divided into a first lumen and a second discharge exhaust lumen, and a filter positioned in the first passageway and the recirculation exhaust lumen. 过滤器可以定位在第一排放管腔的一个端部处并且成一定角度以将固体颗粒引导到第二排放管腔中。 A filter may be positioned at the discharge end of the first lumen and angled to discharge solid particles directed to the second lumen.

[0027] 在一个实施例中,设置了再循环通道,所述再循环通道在排放管腔和高压管之间延伸。 [0027] In one embodiment, provided recirculation passage, the recirculation passage extending between the discharge pipe and the high pressure lumen. 过滤器可以设置在再循环通道中,所述过滤器使得小的固体颗粒能够进入到高压管中,以在喷嘴喷口附近产生喷砂效应。 Filter may be disposed in the recirculation passage, the filter such that small solid particles can enter into the high pressure tube to produce blasting effect near the nozzle orifice.

[0028] 在一个实施例中,将构造成破碎闭塞材料的结构定位在排放管腔内。 [0028] In one embodiment, the occlusive material is configured to break the structure positioned within the exhaust lumen. 所述结构可以包括具有锋利切割边缘的格栅。 The structure may comprise a grid having a sharp cutting edge. 替代地,所述结构可以包括可旋转的涡轮,所述可旋转的涡轮构造成研磨闭塞材料。 Alternatively, the structure may comprise a rotatable turbine, the turbine configured to be rotatable abrasive occlusive material.

[0029] 在一个实施例中,血栓切除术导管包括主体,所述主体限定了位于喷嘴喷口和排放管腔入口之间的窗口,并且笼状物定位成毗邻窗口,以覆盖窗口。 [0029] In one embodiment, the thrombectomy catheter includes a body defining a window between the nozzle inlet orifice and the exhaust lumen, and the cage is positioned adjacent the window to cover the window.

[0030] 能够实施本文描述的装置以实现以下优势中的一个或多个。 [0030] The apparatus described herein can be implemented to realize one or more of the following advantages. 血栓切除术导管采用高压水射流以用于从血管内移除闭塞材料,这比机械切除装置更为安全。 Thrombectomy catheter using high pressure water jet for removing occlusive material from the blood vessel cutting device which is more secure than the mechanical. 公开的血管切除术导管系统尤为适于处理并且移除各种凝块,诸如深静脉血栓形成(DVT),无论血栓形成或凝块的龄期或组构如何。 Vascular catheter ablation disclosed system is particularly suitable for the treatment and removal of various clot, such as deep vein thrombosis (of DVT), regardless of the age of the clot or thrombosis or how fabric. 例如,血栓切除术导管可以移除急性和慢性凝块。 For example, the catheter may be removed thrombectomy acute and chronic clot. 公开的血栓切除术导管可以以多种方式构造而成,以在使得水射流能够移除凝块的同时保护体腔。 Also disclosed thrombectomy catheter may be constructed in various ways, in order to be removed so that the water jet clot protection body cavity. 体腔可以由定位在水射流附近的专门结构保护,所述专门结构提供了抵御切割体腔的物理障碍。 May be protected by a body lumen positioned in the vicinity of the water jet special structure, the special structure provides a physical barrier against the cutting body cavity. 而且,可以通过监控毗邻水射流的体腔中的压力,以向控制器发出信号停止切除(即,关闭水射流)或停止向体腔中注入流体来保护体腔。 Further, by monitoring the pressure of the water jet adjacent the body cavity, to stop the removal of signals (i.e., turned off water jet) or stop injecting a fluid into a body cavity to protect the body cavity to the controller.

[0031] 而且,公开的血栓切除术导管提供了一种注入液体,以提供体腔内的流体平衡,以防止体腔过分消耗血液和流体。 [0031] Further, disclosed thrombectomy catheter provides a fluid injection liquid balance has to provide a body cavity, the body cavity in order to prevent excessive consumption of blood and fluid.

[0032] 而且,不需要用于通过血栓切除术导管将凝块运送出体腔的单独设备,原因在于高压流体提供了使凝块移动通过血栓切除术导管所需的动力。 [0032] Moreover, no need for a thrombectomy catheter through the clot out of the individual conveying apparatus body cavity, because the high pressure fluid moves through the clot provides a thrombectomy catheter required power. 更甚者,公开的血栓术切除导管可以设置有如下设备:所述设备浸溃移除的凝块,以便更好地通过血栓切除术导管转移所述凝块。 What is more, the disclosed for thrombus ablation catheter may be provided with the following equipment: the clot removal device impregnated to better transfer through the thrombectomy catheter clot. 浸溃凝块的设备可以使得浸溃的凝块的更小的颗粒中的一些返回到流体流中,以帮助进一步破碎凝块。 Dipping apparatus may be such that clot clot impregnated smaller particles to return some of the fluid flow, to help further break the clot.

[0033] 本公开的其它特征和优势将从以下描述和权利要求中变得显而易见。 [0033] Other features and advantages of the present disclosure and claims, the following description will become apparent.

附图说明 BRIEF DESCRIPTION

[0034] 在此参照附图描述公开的血栓切除术导管系统的多个实施例,其中: A plurality of [0034] described with reference to the drawings herein disclosed thrombectomy catheter system according to an embodiment, in which:

[0035] 图1是公开的血栓切除术导管系统的一个实施例的示意图; [0035] FIG. 1 is a schematic diagram of one embodiment of the disclosed embodiment of the thrombectomy catheter system;

[0036] 图1A是图解了针对公开的系统的一个实施例每单位时间注入流体流速的曲线图; [0036] FIG 1A is a graph illustrating one case per unit time of the injection fluid flow rate for the embodiment of the disclosed system;

[0037] 图1B是图解了针对公开的系统的另一个实施例每单位时间注入流体流速的曲线图;。 [0037] FIG. 1B is a diagram of Example embodiment per unit time of the injection fluid flow rate graph for another disclosed system;.

[0038] 图2是图1示出的系统的公开的血栓切除术导管的一个实施例的远侧部分的侧视立体图; [0038] FIG. 2 is a diagram illustrating the system of FIG. 1 thrombectomy catheter disclosed a side perspective view of a distal portion of the embodiment;

[0039] 图2A是图2中示出的导管体的远端的立体图,其中,高压管的远端被剖开; [0039] FIG. 2A is a perspective view of the distal end shown in FIG. 2 of the catheter body, wherein the distal end of the high-pressure pipe being cut away;

[0040] 图3A是图2中示出的血栓切除术导管的定位带的正面立体图; [0040] FIG 3A is a front perspective view of FIG. 2 shows a thrombectomy catheter is positioned belt;

[0041] 图3B是图3A中示出的定位带的后立体图; [0041] FIG. 3B is a rear perspective view of FIG. 3A shows the positioning of the belt;

[0042] 图4是公开的血栓切除术导管的替代性实施例的远侧部分的侧立体图; [0042] FIG. 4 is a side perspective view of a distal portion of the thrombectomy catheter disclosed an alternative embodiment;

[0043] 图5是图4中示出的血栓切除术导管的侧剖视图; [0043] FIG. 5 is a cross-sectional view of the catheter shown in FIG. 4 thrombectomy side;

[0044] 图6是沿着图4的截面线条6-6获得的立体剖视图; [0044] FIG. 6 is a perspective cross-sectional view along section line 6-6 of FIG. 4 is obtained;

[0045] 图7是图4中示出的血栓切除术导管的导管体的远端和导管尖端的立体图; [0045] FIG. 7 is illustrated in FIG. 4 thrombectomy perspective view of the distal tip of the catheter and the catheter of the catheter body surgery;

[0046] 图8是图4中示出的导管体和导管尖端的侧视图; [0046] FIG. 8 is a side view of a catheter tip and the catheter body shown in FIG 4;

[0047] 图9是图4中示出的血栓切除术导管的正视图;[0048] 图10是包括血栓切除术导管和引导导管的公开的血栓切除术导管系统的替代实施例的侧面示意图; [0047] FIG. 9 is shown in Figure 4 a thrombectomy catheter elevational view; [0048] FIG. 10 is a disclosure of thrombi thrombectomy catheter and guide catheter cutaway view of surgical side alternative catheter system according to an embodiment;

[0049] 图11是图10中示出的细节的指示区域的放大视图;和 [0049] FIG. 11 is an enlarged view of the indicated area of ​​detail shown in FIG. 10; and a

[0050] 图12是沿着图11的截面线条12-12获得的剖视图; [0050] FIG. 12 is a cross-sectional view along section line 12-12 of FIG. 11 is obtained;

[0051] 图13是公开的血栓切除术导管的替代实施例的侧视图; [0051] FIG. 13 is a thrombectomy catheter disclosed a side view of an alternative embodiment;

[0052] 图14是公开的血栓切除术导管的又一个实施例的侧视图; [0052] FIG. 14 is a thrombectomy catheter disclosed a side view of yet another embodiment of the embodiment;

[0053] 图15是公开的血栓切除术导管的另一个实施例的远端的侧剖视图; Side of the distal end of the embodiment [0053] FIG. 15 is disclosed thrombectomy catheter cross-sectional view of another embodiment;

[0054] 图16是沿着图15的截面线条16-16获得的剖视图; [0054] FIG. 16 is a cross-sectional view along section line 16-16 of FIG. 15 is obtained;

[0055] 图17是公开的血栓切除术导管的另一个实施例的远端的侧剖视图; Side of the distal end of the embodiment [0055] FIG. 17 is disclosed thrombectomy catheter cross-sectional view of another embodiment;

[0056] 图18是沿着图17的截面线条18-18获得的剖视图; [0056] FIG. 18 is a cross-sectional view along section line 18-18 of FIG. 17 is obtained;

[0057] 图19是公开的血栓切除术导管的另一个实施例的侧剖视图; Side of the embodiment [0057] FIG. 19 is disclosed thrombectomy catheter cross-sectional view of another embodiment;

[0058] 图20是公开的血栓切除术导管的又一个实施例的侧剖视图; [0058] FIG. 20 is disclosed thrombectomy catheter has a cross-sectional side view of one embodiment;

[0059] 图21是公开的血栓切除术导管的另一个实施例的侧剖视图;和 [0059] FIG. 21 is a side cross-sectional view of another thrombectomy catheter disclosed embodiments; and

[0060] 图22是公开的血栓切除术导管的又一个实施例的侧剖视图。 [0060] FIG. 22 is disclosed thrombectomy catheter has a cross-sectional side view of an embodiment.

具体实施方式 detailed description

[0061] 现在将参照附图详细描述公开的血栓切除术导管系统的实施例,其中,在若干视图中的每一张中相同的附图标记均表示相似或相同的元件。 [0061] detailed description will now be disclosed embodiment thrombectomy catheter system, wherein each one the same reference numerals in the several views are represented by the same or similar elements. 当在此使用时,术语“远侧”指的是在适当使用期间公开的血栓切除术导管系统或其部件的距诸如医师的用户最远的部分,而术语“近侧”指的是在适当使用期间血栓切除术导管系统或其部件的最靠近用户的部分。 When used herein, the term "distal" refers to the use of an appropriate disclosure during thrombectomy catheter system, such as a member or a portion from the user furthest physician, while the term "proximal" refers to the appropriate thrombus catheter system closest to the user, or partial nephrectomy member during use. 另外,术语“管腔”应当理解为包括人体内的自然或人造的任何管腔,例如,血管、血管移植物、瘘管等。 Further, the term "lumen" should be understood to include any natural or man-made lumen of the human body, e.g., a blood vessel, a vascular graft, fistula and the like. 而且,术语“闭塞物”应当理解为包括任何部分的或整个的管腔堵塞物,例如,血栓、粥样斑、斑块、肿瘤等。 Further, the term "occlusion" should be understood to include any portion of or the entire luminal blockage, e.g., thrombosis, atheroma, plaque, tumors.

[0062] 图1是整体用10示出的公开的血栓切除术导管系统的一个实施例的示意图。 [0062] FIG. 1 is an overall ablation catheter system with a schematic of an embodiment disclosed thrombus 10 shown. 血栓切除术导管系统10包括血栓切除术导管12、注入流体源14、高压流体源16、和用于接收从手术部位排出的流体的贮存器18。 Thrombectomy catheter system 10 includes a thrombectomy catheter 12, injecting a fluid source 14, high pressure fluid source 16, and a reservoir for receiving fluid discharged from the surgical site 18. 注入流体源14和高压流体源16、和排放流体贮存器18中的每一个均分别通过适当的流体管道20a-20c与血栓切除术导管12连通。 Injection fluid source 14 and high pressure fluid source 16, and drain fluid reservoir 18, respectively, each of the fluid conduit by appropriate 20a-20c communicates with thrombectomy catheter 12. 可以将控制装置22设置在将注入流体源14连接到血栓切除术导管12的流体管道20a中。 The control device 22 may be provided in the injection fluid source 14 is connected to the fluid conduit 20a thrombectomy catheter 12. 控制装置22可以包括泵或阀,如以下将更加详细讨论的那样,可以操作所述泵或阀以调节注入流体至血栓切除术导管12的流速。 The control device 22 may include a pump or a valve, as will be discussed in more detail above, the pump or valve can be operated to regulate the injection fluid to flow thrombectomy catheter 12.

[0063] 参照图2-3B,血栓切除术导管12包括导管体24、定位带26和高压管28。 [0063] Referring to FIGS. 2-3B, thrombectomy catheter 12 includes a catheter body 24, the positioning belt 26 and the high pressure pipe 28. 导管12的导管体24限定了至少两个管腔并且可以诸如通过挤压由任何适当的生物相容材料形成,所述生物相容材料足够柔韧,以便有助于将导管12插入到体腔中。 Conduit 24 of the catheter body 12 defining at least two lumens and may be formed of any suitable, such as a biocompatible material by extrusion, the biocompatible material is sufficiently flexible to facilitate insertion of the catheter 12 into the body cavity. 适当的材料包括但是不局限于:聚合材料、弹性体材料(例如,硅酮和织物材料)、或者合成树脂(例如,聚氨酯、聚乙烯、聚丙烯、尼龙、聚四氟乙烯、聚醚醚酮、改性尼龙®、或聚酰亚胺)。 Suitable materials include, but are not limited to: polymeric material, an elastomeric material (e.g., silicone and the fabric material), or a synthetic resin (e.g., polyurethane, polyethylene, polypropylene, nylon, polytetrafluoroethylene, polyetheretherketone , modified nylon ®, or polyimide). 在一个实施例中,导管体24限定了排放管腔30和注入管腔32 (见图2A)。 In one embodiment, the catheter body 24 defines an injection lumen 30 and the exhaust lumen 32 (see FIG. 2A). 排放管腔30限定了排放流体的管腔并且包括与流体管道20c (图1)和排放流体贮存器18流体连通的近端。 Exhaust lumen 30 defines a lumen and includes a proximal end discharge fluid communication with the fluid conduit 18 in fluid 20c (FIG. 1) and a discharge fluid reservoir. 注入管腔32限定了注入流体的管腔并且与流体管道20a (图1)和注入流体源14流体连通。 Injection lumen defining a lumen 32 of the injection fluid and the fluid conduit 20a (FIG. 1) and the injection fluid communication with the fluid source 14. 尽管排放管腔30被图解为是环形的并且注入管腔32被图解为成新月状,但是对于排放管腔30和注入管腔32而言可以预想多种其它构造。 Although illustrated as exhaust lumen 30 is annular and is injected into the lumen 32 is crescent-shaped as illustrated, but for the injection lumen and the exhaust lumen 30 32 For a variety of other configurations can be envisioned.

[0064] 定位带26被支撑在导管体24的远端上并且限定了与导管体24的排放管腔30连通的排放管腔30a和与导管体24的注入管腔32连通的注入管腔32a。 [0064] positioned belt 26 is supported on the distal end of the catheter body 24 and defines an injection lumen in communication with the exhaust lumen 30 of the catheter body 24 and the exhaust lumen 30a in communication with the conduit 32 of the body 24 of the injection lumen 32a . 定位带26包括:第一近侧延伸部34,所述第一近侧延伸部34的形状对应于导管体24的排放管腔30的形状;和第二近侧延伸部36,所述第二近侧延伸部36的形状对应于导管体24的注入管腔32的形状。 Positioning belt 26 comprises: a first proximal portion 34 extends, the shape of the first portion 34 proximal extension corresponds to the shape of the exhaust lumen 30 of the catheter body 24; and a second proximal extension 36, the second proximal extension portion 36 is a shape corresponding to the shape of the injection lumen 24 of the catheter body 32. 近侧延伸部34和36能够被接收在导管体24的排放管腔30和注入管腔32的远端中,以便将定位带26摩擦地固定到导管体24的远端。 34 and the proximal extension portion 36 can be received in the exhaust lumen 30 of the catheter body 24 and the distal end of the injection lumen 32, band 26 is positioned so as to frictionally secured to the distal end of the catheter body 24. 作为摩擦接合的替代方案或附加方案,可以通过包括使用粘合剂、焊接、卷边等的其它紧固技术将定位带26固定到导管体24的远端。 Alternatively or additionally frictional engagement of belt 26 can be positioned to the distal end of the catheter body 24 secured by other fastening techniques include the use of adhesive, welding, crimping or the like. 在一个实施例中,定位带26中的注入管腔32a毗邻定位带26的排放管腔30a,并且所述注入管腔32a可以具有延伸大于大约140°并且优选地大于180°的弧角Θ的区域。 In one embodiment, the injection is located in the lumen 26 with a belt 32a positioned adjacent to the exhaust lumen 26, 30a, and 32a may have the injection lumen extending arc angle of greater than about 140 ° and preferably greater than 180 ° of Θ area. 见图18,定位带26可以由适当的生物相容塑料或者适当的生物相容金属形成,所述生物相容塑料包括聚合物材料(包括热塑料等),所述生物相容金属包括不锈钢、钛等。 Figure 18, belt 26 may be positioned by a suitable bio-compatible plastic or a suitable biocompatible metal, a biocompatible plastics include polymeric materials (including thermoplastics, etc.), the biocompatible metal comprises stainless steel, titanium.

[0065] 高压管28定位成延伸通过注入管腔32并且包括封闭的远端和弯曲部分40,所述弯曲部分40限定了喷嘴喷口40a (见图5)。 [0065] The high pressure tube 28 is positioned to extend through the injection lumen 32 and includes a closed distal end 40 and a curved portion, the curved portion 40 defines a nozzle orifice 40a (see FIG. 5). 如所图解的那样,弯曲部分40定位成横向于导管体24的纵向轴线,使得喷嘴喷口40a定位成沿着基本平行于导管12的纵向轴线的方向引导流体射流50进入到定位带26的排放管腔30a中。 As illustrated above, the bent portion 40 is positioned transverse to the longitudinal axis of the catheter body 24, the nozzle orifice positioned to direct fluid jets 40a into the discharge pipe 50 positioned along belt 26 substantially parallel to the longitudinal axis of the catheter 12 chamber 30a. 尽管弯曲部分40示出为从导管体24的纵向轴线偏移大约90度,但是可以设想的是弯曲部分40可以弯曲大约180°,并且喷嘴喷口40a能够形成在高压管28的远端中。 Although the curved portion 40 is shown as offset from the longitudinal axis of the catheter body 24 is approximately 90 degrees, it is contemplated that the curved portion 40 may be bent about 180 °, and the nozzle orifice 40a can be formed at the distal end 28 of the high-pressure pipe. 在一个实施例中,高压管28由诸如镍钛诺或不锈钢的金属形成。 In one embodiment, the high pressure tube 28 is formed from a metal such as nitinol or stainless steel. 可替代地,高压管28可以由诸如聚醚醚酮的热塑性材料形成。 Alternatively, the high pressure tube 28 may be formed from a thermoplastic material such as polyetheretherketone. 可以使用例如粘合剂、焊接等将高压管28固定或粘合到定位带26,以确保相对于定位带26的排放管腔30a适当地定位管28的喷嘴喷口40a,如将在下文更加详细描述的那样。 It may be used such as adhesives, welding or the like the high-pressure pipe 28 is fixed to the positioning belt 26 or adhesive, to ensure that exhaust lumen 26 is positioned with the nozzle 30a is properly positioned with respect to the spout tube 28 40a, as will be hereinafter more detail as described. 可替代地,可以相对于定位带26的排放管腔30a可滑动地定位高压管28,以便能够选择性地变化喷嘴喷口40a和排放管腔30a之间的间隔。 Alternatively, the high pressure tube 28 may be positioned exhaust lumen 30a of the belt 26 may be slidably positioned with respect, to be able to selectively vary the spacing between the nozzle orifices 40a and exhaust lumen 30a. 在一个实施例中,定位带26包括上和下凹状部分46a和46b (图3A),所述上和下凹状部分46a和46b的尺寸被设计成接收高压管28并且最小化管28相对于带26的横向运动。 In one embodiment, the positioning tape 26 includes upper and lower concave-shaped portion 46a and 46b (FIG. 3A), and the size of the concave-shaped portions 46a and 46b are designed to receive a high pressure tube 28 and the tube 28 is minimized relative to the belt 26 of lateral movement.

[0066] 如以上所讨论的那样, 喷嘴喷口40a可以与定位带26的排放管腔30a向远侧间隔开预定距离。 [0066] As discussed above, the nozzle spout 40a may be positioned with the discharge opening 30a of the lumen 26 distally a predetermined distance interval. 喷嘴喷口40a可以是圆筒状,以产生基本对称的锥形射流(见图2)。 Nozzle spout 40a may be cylindrical, conical jets to produce substantially symmetrical (see FIG. 2). 在一个实施例中,喷嘴喷口40a的直径处于大约0.001英寸至0.01英寸之间。 In one embodiment, the orifice diameter of the nozzle 40a is between about 0.001 to 0.01 inches. 可替代地,喷嘴喷口40a可以是锥形,其中,喷嘴喷口40a的进口开口的直径大于喷嘴喷口40a的排放开口的直径。 Alternatively, the nozzle spout 40a may be tapered, wherein the diameter of the nozzle inlet orifice 40a of the nozzle opening is greater than the diameter of the discharge orifice 40a opening. 这样的锥形喷口更适于与更低的流体压力使用。 Such a tapered nozzle is more suited to lower pressure fluid. 如以上讨论的那样并且如在图2中示出的那样,喷嘴喷口40a产生的流体射流50构造成被完全接收在定位带26的排放管腔30a 内。 As and as shown in FIG. 2, as discussed above, the fluid jet nozzle orifice 40a generates 50 is configured to be fully received within the exhaust lumen 26 of the belt 30a positioned.

[0067] 在公开的血栓切除术导管12的一个实施例中,排放管腔30a的直径是大约0.050英寸,圆筒形射流喷嘴40a的直径大约为0.005英寸并且喷嘴喷口40a和排放管腔30a之间的间隔大约为0.008英寸。 [0067] In a disclosed thrombectomy catheter 12 embodiment, the diameter of the discharge lumen 30a is about 0.050 inches and the diameter of the cylindrical jet nozzle 40a is about 0.005 inches and the nozzle orifices 40a and 30a of the exhaust lumen interval between about 0.008 inches. 可替代地,喷嘴喷口40a和排放管腔30a之间的间隔大约为 Alternatively may be spaced between the nozzle discharge orifice 40a and a lumen 30a of about

0.060英寸。 0.060 inches. 可替代地,可以选择其它尺寸以优化通过导管12的排放管腔30a和排放管腔30吸入的流体流量。 Alternatively, other dimensions may be selected to optimize fluid flow through the exhaust lumen 30a and the discharge lumen 30 of the catheter 12 is drawn.

[0068] 参照图1和图2,当血栓切除术导管系统10用于从血管内移除闭塞材料时,使用标准经皮进入技术将血栓切除术导管12定位在患者的静脉系统中。 [0068] Referring to FIGS. 1 and 2, when the thrombectomy catheter system 10 for removing occlusive material from the blood vessel using standard percutaneous access techniques thrombectomy catheter 12 is positioned in the patient's venous system. 虽然没有示出,但是导管体24和定位带26可以形成为包括导丝孔,以辅助将导管12放置在患者血管腔内。 Although not shown, the catheter body 24 and the positioning belt 26 may be formed to include a guidewire aperture 12 to assist in placement of the catheter in a blood vessel lumen of a patient. 可替代地,可以沿着注入管腔32向下传递导丝,以影响导管12的放置。 Alternatively, it may be injected along the guide wire is passed down the lumen 32, 12 to affect the placement of the catheter. 在导管12定位在血管腔内的情况下,推进导管12以将导管12的远端定位在闭塞材料内或者抵接闭塞材料。 In the catheter 12 is positioned in the blood vessel lumen, the pusher catheter 12 to the distal end of catheter 12 is positioned within the occlusive material occluding material or abut. 然后将诸如盐水或水的加压流体以大约IOOpsi至大约10,OOOpsi的压力从高压流体源16经由流体管道20b供应到高压管28。 Then a pressurized fluid such as saline or water, about IOOpsi to about 10, OOOpsi pressure from a high pressure fluid source 16 via the fluid supply pipe 28 to the high pressure conduit 20b. 可替代地,诸如组织型纤溶酶原激活物的血栓溶解剂可以混合在加压流体中。 Alternatively, the thrombolytic agent such as tissue plasminogen activator may be mixed in a pressurized fluid. 高压流体行进通过高压管28并且作为高压流体射流50离开喷嘴喷口40a (图5)。 The high pressure fluid travels through the high pressure pipe 28 and as a high pressure fluid jet 50 exiting the nozzle orifice 40a (FIG. 5). 当高压流体射流50进入到定位带26的排放管腔30a中时,流体射流50导致将周围流体和闭塞材料挟带到排放管腔30a附近的射流中。 When the high pressure fluid jet 50 into the exhaust lumen 30a in the positioning belt 26, 50 cause the fluid jet entraining fluid surrounding the lumen and occlusive material 30a to the vicinity of the discharge jet. 取决于所公开的多种参数,产生了真空并且所述真空可以处于IOmmHg至760mmHg的范围内。 Depending on the various parameters disclosed, it produces the vacuum and the vacuum may be in a range of IOmmHg to 760mmHg. 当发生这种情况时,闭塞材料被抽吸与高压射流50相接触并且被切除。 When this occurs, the occlusion material is drawn into contact with the high pressure jet 50 and is cut. 已经切除的闭塞材料和血管腔中的诸如血液的流体被从血管腔排入到导管体24的排放管腔30、30a中,在所述排放管腔30和30a处,所述已经切除的闭塞材料和流体从导管12向近侧流至管道20c并且流入到排放流体贮存器18中。 Has been removed fluid such as blood and vascular occlusion material chamber is discharged from the discharge chamber into the vessel lumen 24 of the catheter body 30,30a, at the discharge lumen 30 and 30a, the occlusion has been removed material and the flow of fluid from conduit 12 to the conduit 20c proximally 18 and flows into the discharged fluid reservoir.

[0069] 为了取代因血管腔内的高压流体射流50产生的抽吸效应而从血管腔中移除的流体,通过导管体24的注入管腔32从注入流体源14将流体供应或注入到血管腔中。 [0069] In order to replace the fluid suction effect due to the high pressure fluid jet generated by the vessel lumen 50 and removed from the blood vessel lumen, lumen of the catheter body 24 by injecting the injection fluid from the fluid supply source 14 is injected into the blood vessel 32 or cavity. 注入管腔32还可以如以下所描述的那样用于将血栓溶解剂或显影剂引入到血管腔中。 Injection lumen 32 may also be used as described below, or thrombolytic agents introducing developer into the vessel lumen. 在一个实施例中,通过由高压射流50在注入管腔32的远端附近的血管腔中产生的负压而将注入流体(其可以是盐水)被动地抽吸到注入管腔32中。 In one embodiment, high-pressure jet 50 by the negative pressure in the injection lumen 32 near the distal end of the lumen generated by the injection fluid (which may be brine) passively drawn into the lumen 32 of the injection. 在所述实施例中,可以定位在将注入流体源14连接到导管12的流体管道20a中的控制装置22可以包括调节阀,能够选择性地操作所述调节阀以控制流动到导管12的注入流体流速。 In the illustrated embodiment, may be positioned in the injection fluid source 14 is connected to a control fluid conduit means 20a in the conduit 12 may include a control valve 22, into said selectively operable to control the flow regulating valve 12 to the conduit fluid flow rate. 在所述实施例中,通过调节阀可以周期性地变化供应到导管12的注入管腔32的流体流速,以辅助破碎闭塞材料。 In the illustrated embodiment, it may be periodically vary the flow rate of the fluid supplied to the injection lumen 32 of the catheter 12 by adjusting the valve to closed secondary crushing material. 具体地,由周期性变化通过注入管腔32供应的流体流速所导致的流体脉动可以有助于破坏闭塞材料或使闭塞材料破碎。 In particular, by the pulsating flow supplied periodically changing fluid flow rate through the injection lumen 32 may contribute to the destruction caused by occluding the occluding material or a material break. 在其它被动实施例中,可以不存在控制装置22,并且通过在血管腔内产生的真空使注入流体源14内的流体自由运动。 In other embodiments, the passive, the control means 22 may not be present, and the free movement of the injection fluid within the fluid source 14 by a vacuum generated by making endovascular.

[0070] 在替代性实施例中,控制装置22可以包括泵(诸如齿轮泵或蠕动泵),以将加压的注入流体流供给到导管12的注入管腔32。 [0070] In an alternative embodiment, the control device 22 may include a pump (such as a gear pump or a peristaltic pump), to the pressurized fluid injected into the injection cavity 32 is supplied to the conduit 12. 在这样的实施例中,可以周期性变化供应到导管12的注入管腔32的流体流速,以如以上所讨论的那样辅助破碎闭塞材料。 In such an embodiment, the change may be periodically injected into the fluid flow rate supplied to the lumen 32 of the catheter 12, to as secondary crushing As discussed above occlusive material. 随时间周期性变化供应到导管12的注入管腔32的流体流速还可以最小化血管腔的壁被抽吸到与高压射流50相接触的可能性。 Periodically changing with time supplied to the injection lumen 32 of the catheter 12 in fluid flow rate may also minimize vessel lumen wall 50 is drawn into the possibility of contact with the high-pressure jet. 流速的周期性变化可以是如图1A-1B所示的方波或正弦波的形式,并且可以具有处于0.5Hz至2.0Hz范围内的频率。 Periodically changing the flow rate may be in the form of a square wave or a sine wave as shown in FIG. 1A-1B, and may have a frequency in a range of 0.5Hz to 2.0Hz.

[0071] 参照图1,可以在将导管12的排放管腔30连接到排放流体贮存器18的流体管道20c中设置限流器23。 [0071] Referring to FIG. 1, flow restrictor 23 may be provided in the exhaust lumen 30 of the catheter 12 is connected to the discharge fluid reservoir in fluid conduit 20c 18. 限流器23可以包括用于压缩或者卷曲流体管道20c的机械装置。 Flow restrictor 23 may comprise a compressed or crimped fluid conduit 20c mechanical means. 可替代地,其它可变的限流器装置可以包括在流体管道20c中。 Alternatively, other variable flow restrictor means may be included in the fluid conduit 20c. 限流器23用于选择性地变化因高压流体射流50产生的挟带而吸入的流体的量并且因此可以能够控制在排放管腔30的远端处产生的真空。 The amount of fluid flow restrictor 23 selectively varied for entrainment due to high pressure generated by fluid jets 50 and thus the suction and discharge may be able to control the vacuum lumen 30 at the distal end generated. 在一个实施例中,可以选择性地操作限流器23,以随时间周期性地改变限流。 In one embodiment, may be selectively operated flow restrictor 23, is periodically changed with time to limiting. 替代地,可以设置流量计(未示出)以测量被吸入流体管道20C (其附接到贮存器18的)中的流体的流体流速,并且能够操作限流器23以控制排放管腔30中的流体流速匹配注入管腔32中的流体流速。 Alternatively, the meter may be provided (not shown) to measure fluid flow rate of fluid is drawn into a fluid conduit 20C (which is attached to the reservoir 18) in, and operable to control the flow restrictor 23 of the exhaust lumen 30 fluid flow rate matches the flow rate of fluid injected into the lumen 32.

[0072] 在一个实施例中,压力传感器与血栓切除术导管结合成一整体,以辅助平衡从体腔中吸出的流体容积与注入到体腔中的流体容积。 [0072] In one embodiment, the pressure sensor and the thrombectomy catheter integrated into one, to assist in balancing the aspirated volume of fluid from the body cavity with the volume of fluid injected into the body cavity. 再次参照图2,一个或多个传感器80a-c可以定位在血栓切除术导管12上的多个位置处,包括在高压管28上的位置(80c)、在定位带26的正面上的位置(80b)、和/或在定位带26的外表面上的位置(80c)。 Referring again to Figure 2, one or more sensors 80a-c may be positioned at a plurality of positions thrombectomy on the catheter 12, including position (80c) on the high pressure pipe 28, the position on the front side 26 of the retaining band ( 80b), and / or location (80c) is positioned in the outer surface of the belt 26. 可替代地,传感器可以定位在位于血栓切除术导管12上的其它外部或内部位置处。 Alternatively, the sensor may be positioned at other thrombectomy located external or internal position of the catheter 12. 在一个实施例中,传感器可以是小轮廓纤维光学传感器,诸如,由Fiso Technologies, Inc.或者Opsens, Inc生产的小轮廓纤维光学传感器。 In one embodiment, the sensor may be a low-profile fiber optic sensor, such as by Fiso Technologies, Inc. or Opsens, Inc low profile produced fiber optic sensor. 替代地,可以使用其它类型的压力传感器测量血栓切除术导管正在处理的体腔内的压力。 Alternatively, other types of pressure sensor measures the pressure within the body cavity thrombectomy catheter being processed. 传感器的位置应当选择成准确测量体腔内的压力而非紧邻导管12的远端处的压力。 Position sensor to accurately measure the pressure should be selected rather close to the pressure within the body cavity at the distal end of catheter 12. 如此,用于放置传感器的最佳位置是与排放管腔30a、30的远端间隔开的位置、特别是规避了流体流入或者流出导管12的位置。 Thus, the best location for placement of the sensor 30a, the distal end 30 spaced apart locations with the discharge lumen, in particular to avoid the fluid flowing into or out of the position of the catheter 12.

[0073] 可替代地,传感器80可以定位在导管12的管腔内(未示出),或者定位在导管的附件(诸如导丝或分开的引导导管)上。 [0073] Alternatively, the sensor may be positioned within the lumen 80 of the catheter 12 (not shown), or positioned in the attachment of the catheter (such as a guidewire or a separate guide catheter) on. 另外,分开的压力监控管腔(未示出)可以设置在导管12中,所述分开的压力监控管腔与体腔连通并且与体外的应变仪等连通,以监控体腔内的流体压力。 Further, a separate pressure monitoring lumen (not shown) may be provided in the duct 12, separated from the pressure monitoring lumen in communication with the body cavity communicates with the in vitro and strain gauges to monitor the fluid pressure within the body cavity. 注意的是,如果将传感器定位在导管12的离开管腔内,诸如定位在排放管腔30中,则在进行压力测量之前必须停止流过管腔的流动,以获得反映体腔内的压力而非排放管腔内的压力的读数。 Note that, if the sensor is positioned within the lumen 12 exits the catheter, positioned in the exhaust lumen 30, such as, you must stop during the flow through the lumen before pressure measurements to obtain a pressure within the body cavity not reflect reading of the pressure within the exhaust lumen. 在这样的实施例中,流动限流器23可以用于周期性停止流动,以能够定期测量体腔内的压力。 In such an embodiment, the flow restrictor 23 may be used to periodically stop the flow, pressure within the body cavity can be measured periodically.

[0074] 提供压力传感器测量体腔内的压力的目的是保持通过排放管腔30从体腔移除的流体容积与通过注入管腔32注入到体腔中的流体容积之间的平衡。 [0074] providing a pressure sensor measuring the pressure within the body cavity of the object of holding a volume of fluid through exhaust lumen 30 and removed from the body cavity through the injection lumen 32 is injected into the balance between the volume of fluid in the body cavity. 在使用中,在操作导管12之前,测量管腔压力以建立管腔内的基线压力。 In use, prior to operation of the catheter 12, a pressure measuring lumen to establish a baseline pressure in the lumen. 此后,通过高压管28供应高压流体,使得射流50进入到排放管腔30a、30中。 Thereafter, the high pressure fluid supplied by the high-pressure pipe 28, so that the jet 50 into the exhaust lumen 30a, 30 in. 当射流50进入到排放管腔30a、30时,产生文丘里效应,所述文丘里效应在排放管腔30a周围和体腔内抽吸真空,使得包括闭塞材料的流体被抽吸到排放管腔30、30a中。 When the jet 50 into the exhaust lumen 30a, when 30, creating a venturi effect, the venturi effect in the discharge lumen and a body cavity 30a surrounding the vacuum suction, such that a fluid blocking material is drawn into the exhaust lumen 30 , 30a in. 当压力传感器80检测到体腔内的压力已经下降到阈值压力以下(例如,下降到管腔基线压力的90%以下)时,则发出信号开始通过注入管腔32注入。 When the pressure sensor 80 detects the pressure within the body cavity has fallen below a threshold pressure (e.g., down to 90% or less of the baseline pressure lumen), the start signal is issued through the injection lumen 32 injection. 当达到第二阈值压力(例如基·线压力的105%)时,发出信号停止注入。 When the pressure reaches a second threshold value (e.g. 105% of the base-line pressure), the injection stop signals. 能够使用已知的流体控制装置自动控制启动和停止注入的过程。 It can be used a known fluid control means for automatically controlling starting and stopping of the injection process. 可替代地,传感器可以用于操作控制装置22或者限流器23,以平衡流入导管12和流出导管12的流体流量。 Alternatively, the sensor may be used to control the operation of apparatus 22 or the flow restrictor 23, to balance the inflow conduit 12 and outflow conduit 12 of the fluid flow.

[0075] 尽管上述血栓切除术导管12最适于移除急性至亚急性闭塞材料,但是导管12完全能够从血管腔内移除所有类型的闭塞材料,包括慢性凝块。 [0075] Although the above thrombectomy catheter 12 adapted to remove most acute to subacute occlusion material, the catheter 12 can be removed completely for all types of occlusive material from the blood vessel lumen, including chronic clot. 为了从血管腔内移除所有类型的闭塞材料,导管12的远端必须被推入到闭塞材料中,以能够将闭塞材料定位在导管12的远端附近,从而闭塞材料能够被抽吸到射流50中、切除并且被浸溃。 In order to remove all types of occlusive material from the blood vessel lumen, the distal end of the catheter 12 to be pushed into the occluded material to a material capable of occluding positioned near the distal end of the catheter 12, thereby occluding material can be drawn into the jet 50, the cut and is impregnated.

[0076] 参照图4至图8,为了在将导管12插入到血管腔中或者在血管腔内操纵导管12期间最小化可能对血管腔造成损伤的可能性,导管12可以装配有防损伤尖端60。 [0076] Referring to FIG. 4 to FIG. 8, in order to minimize the possibility of damage to the catheter 12 may be inserted into a blood vessel or lumen catheter is manipulated during the endovascular vascular lumen 12, the catheter 12 may be equipped with an atraumatic tip 60 . 防损伤尖端60包括主体62,所述主体62具有从主体62的近端朝向主体62的远端减小的高度和宽度,使得远端限定了钝表面64。 Atraumatic tip 60 includes a body 62, a body 62 having a height and width toward the distal end 62 of the body decreases from the proximal end of the body 62, such that the distal end defines a blunt surface 64. 可替代地,主体62的远端可以更尖,以使导管12进一步能够进入闭塞材料中。 Alternatively, the distal end of the body 62 may be sharper, so that the occlusion catheter 12 is further able to enter the material. 主体62还限定了:中央腔66;上开口或切除窗口68,用于接收闭塞材料;和一对注入通道70,所述一对注入通道70与定位带26的注入管腔32a和导管体24的注入管腔32连通。 Body 62 further defines: a central chamber 66; opening or cutting window 68 for receiving the blocking material; and a pair of injection channel 70, the pair of positioning the injection channel 70 with the injection lumen 26 of the catheter body 24 and 32a the injection lumen 32 in communication. 注入通道70可以包括封闭部分70a和敞开部分70b。 Injection channel 70 may comprise a closed portion 70a and an open portion 70b. 注入通道70均可以具有:敞开部分70b的近端,所述敞开部分70b的近端与喷嘴喷口40a大体纵向地对齐;和远端,所述远端延伸远离喷嘴喷口40a。 The injection channel 70 may each have: an open proximal end portion 70b of the open proximal end portion 70b generally aligned with the nozzle spout longitudinally 40a; and a distal end, said distal end extending away from the nozzle spout 40a. 防损伤尖端60中的注入通道70的远侧开口可以是纵向(如图7-9所示)或横向的(未示出)。 Injury preventing The distal tip 60 of the injection passage 70 may be a longitudinal opening (shown in Figures 7-9) or transverse (not shown).

[0077] 使用包括粘合剂、焊接等的任何已知紧固技术将防损伤尖端60固定到导管体24的远端。 [0077] The use comprises an adhesive, welding or the like of any known fastening technique atraumatic tip 60 is fixed to the distal end of the catheter body 24. 当尖端60固定到导管体24时,高压管28的弯曲部分40定位在防损伤尖端60的中央腔66内,使得喷嘴喷口40a与定位带26的排放管腔30a对准。 When the tip 60 is secured to the catheter body 24, high pressure pipe 28 of the curved portion 40 is positioned within the atraumatic tip 60 of the central cavity 66, so that the nozzle discharge orifice 40a is positioned with the lumen 26 is aligned 30a.

[0078] 防损伤尖端60为公开的血栓切除术导管12提供了若干优势。 [0078] The atraumatic tip 60 is disclosed thrombectomy catheter 12 provides several advantages. 更加具体地,防损伤尖端60的渐缩构造可以有助于将导管12的远端定位在闭塞材料中,以促进将闭塞材料定位在高压射流50内。 More specifically, the atraumatic tip 60 of tapered configuration may facilitate positioning the distal end of the catheter 12 occluding material, to facilitate the occlusion material 50 positioned within the high-pressure jet. 另外,在毗邻或远离喷嘴喷口40a的纵向位置处注入通道70的沿着防损伤尖端60的侧壁的构造和定位可以在Btt邻导管的防损伤尖端60的血管腔内产生流体的再循环模式,这将有助于导管12进入到坚硬的闭塞材料中并且从血管腔移除闭塞材料。 Further, in the recirculation mode adjacent or at a longitudinal position away from the nozzle spout 40a may generate a fluid injection channel endovascular injury preventing the tip 60 of the catheter 70 o Btt atraumatic tip 60 along the side walls of the construction and positioning this will help the catheter 12 into the occluding material and hard to remove occlusive material from the blood vessel lumen. 更甚者,防损伤尖端60的渐缩构造还可以使闭塞材料能够进入到切除窗口68中。 What is more, atraumatic tapered tip 60 may also be configured to enable occlusive material to enter the cutting window 68. 具体地,当防损伤尖端60推入到闭塞材料中,并且闭塞材料沿着防损伤尖端60的倾斜平面运动时,闭塞材料的任何弹性均将抵抗防损伤尖端60推回,并且因此闭塞材料进入到切除窗口68 中。 Specifically, when the atraumatic tip 60 is pushed into the occluding material, and the closing movement of the material along the inclined plane of the atraumatic tip 60, any elastic occlusive material will resist both atraumatic tip 60 is pushed back, and thus into the occlusive material 68 to the cutting window.

[0079] 在图7中以虚线示出的替代性实施例中,可以在尖端60的主体62中在注入通道70和腔66之间设置一个或多个微通道82。 [0079] In Figure 7 an alternative embodiment shown in phantom embodiment, the body 62 may be injection tip 60 is provided with one or more micro-channels 82 between the passage 70 and the chamber 66. 微通道82保持注入流体在导管体24的注入管腔32和防损伤尖端60的中央腔66之间流动的路径。 Microchannels 82 holding injection fluid path between the injection lumen 32 of the catheter body 24 and the atraumatic tip 60 of the central chamber 66 flows. 在防损伤尖端60定位在闭塞材料内以使得通道70被阻塞的情况中,微通道82使流体能够在防损伤尖端60内在注入管腔32、32a和中央腔66之间循环。 In the case where atraumatic tip 60 is positioned within the occluding material such that the passage 70 is blocked, the micro-channel 82 allow fluid to the anti-intrinsic damage injection tip 60 is circulated between the chamber 66 and the central lumen 32,32a. 可替代地,微通道82可以沿着防损伤尖端60的外表面形成,并且在注入通道70和切除窗口68之间延伸。 Alternatively, the microchannels 82 may be formed along the outer surface of the atraumatic tip 60, and 68 extend between the injection passages 70 and the cutting window.

[0080] 在另一个实施例中,防损伤尖端60具有微通道82,以使得能够在中央腔66和注入通道70之间建立流体联接。 [0080] In another embodiment, the atraumatic tip 60 having a microchannel 82 can be established so that the fluid coupling between the lumen 66 and the injection passage 70. 微通道82是将中央腔66和注入通道70分开的壁中的孔或者是由防损伤尖端60的表面上位于注入通道70和切除窗口68之间的凹陷部形成的敞开通 Microchannels 82 are open through the recess portion 68 is located between the injection channel 70 and the upper surface of the cutting window hole 66 and the central lumen 70 of the injection channel separating walls or atraumatic tip 60 is formed

道。 Road.

[0081] 参照图10-12,引导导管100可以用于辅助将血栓切除术导管12定位在血管腔102内(图10)。 [0081] Referring to FIGS. 10-12, the guide catheter 100 may be used to assist the thrombectomy catheter 12 is positioned within lumen 102 (FIG. 10). 在一个实施例中,引导导管100包括引导导管体104、近侧球囊106和远侧球囊108。 In one embodiment, the guide catheter 100 includes a guide catheter body 104, a proximal balloon 106 and a distal balloon 108. 引导导管体104可以由尼龙、聚氨酯或诸如改性尼龙®的弹性体形成并且可以包括诸如不锈钢或镍钛诺的增强材料。 Guide catheter body 104 may be formed of nylon, a polyurethane or an elastomer such as a modified nylon ®, and may include a reinforcing material such as stainless steel or nitinol. 引导导管体104限定了多个管腔,所述多个管腔包括:引导腔110,所述引导腔110的尺寸被设计成接收血栓切除术导管12 ;膨胀腔112,所述膨胀腔112用于使近侧球囊106膨胀/缩小;和膨胀腔114,所述膨胀腔114用于使远侧球囊108膨胀/缩小。 The guide catheter body 104 defining a plurality of lumens, said plurality of lumens comprises: guiding chamber 110, the size of the cavity 110 of the guide is designed to receive thrombectomy catheter 12; expansion chamber 112, expansion chamber 112 with the the proximal balloon 106 to cause inflation / deflation; and an expansion chamber 114, expansion chamber 114 for the distal balloon 108 inflation / deflation. 弓丨导导管100可以具有适当的尺寸,例如,IOF或12F的导管。 Shu bow guide catheter 100 may have an appropriate size, e.g., the IOF or conduit 12F. 可替代地,可以设置单个膨胀腔以用于近侧球囊106和远侧球囊108。 Alternatively, a single inflation lumen may be provided for the proximal balloon 106 and a distal balloon 108. 引导导管100还可以限定其它的管腔(未示出),用于将盐水或者血栓溶解剂(诸如组织型纤溶酶原激活物(tPA)、溶栓酶、尿激酶或肝素等)注入到血管腔中。 Guide catheter 100 may also define additional lumen (not shown) for brine or thrombolytic agent (such as tissue plasminogen activator (of tPA), streptokinase, urokinase or heparin, etc.) into vascular cavity.

[0082] 参照图10,引导导管100的位于近侧球囊106和远侧球囊108之间的至少一部分包括正弦形状116。 [0082] Referring to FIG 10, the guide 106 is located proximal of the balloon and the distal balloon 108 comprises at least a portion between the sinusoidal shape 116 of the catheter 100. 如所示出的那样,正弦形状116可以延长引导导管100的近侧球囊106和远侧球囊108之间的整个长度。 As shown, a sinusoidal shape 116 can extend the entire length of the guide between the catheter proximal and distal balloon 106 of the balloon 108 100. 另外,可以通过热定形聚醚醚酮材料形成正弦形状116。 Further, a sinusoidal shape 116 may be formed by heat setting polyetheretherketone material. 替代地,可以设想形成正弦形状116的其它方法。 Alternatively, other methods may be envisaged sinusoidal shape 116 is formed. 替代地,可以将正弦形状赋予血栓切除术导管12。 Alternatively, the sinusoidal shape may be imparted thrombectomy catheter 12. 在这种情况中,引导导管100的位于近侧球囊106和远侧球囊108之间的至少一部分将具有足够的柔性,以当将血栓切除术导管12插入到引导导管100中时呈现正弦形状。 In this case, the guide catheter is located proximal of the balloon 106 and distal balloon 100 between at least a portion 108 will have sufficient flexibility to when the thrombectomy catheter 12 is inserted into the guide catheter 100 presents a sinusoidal shape.

[0083] 如图12所示,引导导管100包括一系列开口120a_120d,所述开口120a_120d定位在导管周围,以提供从引导导管100内进入到血管腔的进入路径。 [0083] As shown in FIG 12, the guide catheter 100 includes a series of openings 120a_120d, the opening 120a_120d positioned around the catheter, to provide access from the guiding catheter into the lumen 100 into a blood vessel path.

[0084] 在使用中,可以使用标准放置技术(诸如使用导丝)将引导导管100定位在血管腔内,使得将闭塞材料定位在近侧球囊106和远侧球囊108之间。 [0084] In use, using standard placement techniques (such as a guidewire) guide catheter 100 is positioned in the blood vessel lumen, so that the occlusive material is positioned between the proximal and distal balloon 106 of the balloon 108. 能够膨胀球囊106和108,以在血管腔内将闭塞材料限制在球囊之间。 106 and 108 can be an inflatable balloon, to endovascular occlusion balloon material is confined between. 此后,如果需要,诸如组织型纤溶酶原激活物的血栓溶解剂能够通过其它管腔(未示出)注入到血管腔中,所述其它管腔设置在引导导管中以用化学方法处理闭塞材料。 Thereafter, if desired, a thrombolytic agent such as tissue plasminogen activator can be injected through another lumen (not shown) into the vessel lumen, the other lumen is provided to the guide catheter occlusion chemically treated material. 尽管能够将血栓溶解剂通过引导导管的不同通路传送到血管腔中,但是比较有利的是通过更小直径的通路注入血栓溶解剂,使得血栓溶解剂以一定速度被引导在闭塞材料上。 Although thrombolytic agent can be transferred to a different vessel cavity through passage guiding catheter, but more advantageously by injection via a smaller diameter thrombolytic agents, thrombolytic agent that is guided at a constant speed in the occlusion material.

[0085] 在已经使用血栓溶解剂处理闭塞材料之后,能够通过引导导管100插入血栓切除术导管12。 [0085] After the process of occlusion material has been used thrombolytic agents, thrombectomy catheter can be inserted through the guide catheter 12 100. 如图11所图解的那样,优选地将血栓切除术导管12定位在引导导管100内与正弦形状的波峰“C”间隔开距离“D”的位置处。 As illustrated in FIG. 11, it is preferable to thrombectomy catheter 12 is positioned within the guide catheter 100 to the peak sinusoidal shape of "C" at a position spaced apart by a distance of "D". 因为正弦形状的波峰“C”将定位成毗邻血管102的壁,所以将血栓切除术导管12的远端与波峰“C”间隔开距离“D”最小化了血管102的壁被抽吸到流体射流50中的可能性(图5),从而最大化了装置的安全性。 Since the peak of the sinusoidal shape "C" will be positioned adjacent the wall of the blood vessel 102, it will thrombectomy catheter 12 with the distal end of the peak "C" spaced apart by a distance "D" 102 minimizes vessel wall is drawn into the fluid possibilities jets 50 (FIG. 5), so as to maximize the safety of the device. 在将血栓切除术导管12适当定位在引导导管100内之后,能够以以上所讨论的方式操作血栓切除术导管12以从血管102移除其它闭塞材料。 In the thrombectomy catheter 12 is properly positioned after the guide catheter 100, it can be in the manner discussed above operation thrombectomy catheter 12 to remove the other occlusive material from the blood vessel 102.

[0086] 可以设想的是引导导管100和血栓切除术导管12能够一起使用,而不用首先通过引导导管注入血栓溶解剂。 [0086] It is contemplated that guide catheter 100 and thrombectomy catheter 12 can be used together, without first injecting a thrombolytic agent through the guide catheter. 还能够设想的是,能够通过血栓切除术导管12 (诸如通过导管体24的注入管腔32)将血栓溶解剂注入到血管102中。 It can also be envisaged that the catheter 12 can be cut by the thrombus thrombolytic agent is injected into a blood vessel 102 (such as by injection cavity 32 of the catheter body 24).

[0087] 图13和图14图解了整体用212 (图13)和312 (图14)示出的公开的血栓切除术导管的替代实施例。 [0087] FIG. 13 and FIG. 14 illustrates a whole by 212 (FIG. 13) and 312 (FIG. 14) shows the thrombectomy disclosed alternative embodiment of a catheter. 导管212和312基本与导管12相似,除了高压管228、328构造成沿着与导管的纵向轴线成一定角度的方向将高压射流250、350引导到导管的排放管腔230、330中之外。 Conduits 212 and 312 are substantially similar to catheter 12, except that the high-pressure pipe 228, 328 is configured to move along the longitudinal axis of the catheter in the angled direction 250, 350, high-pressure jet directed into the catheter lumen 230, 330 outside the discharge. 更加具体地,导管212包括高压管228,所述高压管228具有喷嘴喷口,所述喷嘴喷口沿着轴线J引导高压射流250,所述轴线J相对于导管212的纵向轴线K限定了大约15度和大约75度之间的角度β。 More specifically, the catheter 212 comprises a high pressure pipe 228, the pipe 228 has a high-pressure nozzle orifice, the nozzle orifice along the axis of the guide pressure jet 250 J, the axis J relative to the longitudinal axis of the catheter 212 defines a K of about 15 degrees and an angle between about 75 degrees β. 在一个实施例中,β可以介于大约30度和大约60度之间并且可以大约为45度。 In one embodiment, β may be between about 30 degrees and about 60 degrees and may be approximately 45 degrees. 导管212的构造有助于更加便捷地使导管212进入到闭塞材料中。 The conduit structure 212 contributes to more easily enter the catheter 212 into the occlusion material.

[0088] 参照图14,导管312包括高压管328,所述高压管328包括喷嘴喷口,所述喷嘴喷口沿着轴线J引导高压射流350,所述轴线J相对于导管312的纵向轴线K限定了大约90度的角度β。 [0088] Referring to FIG. 14, the catheter 312 comprises a high pressure pipe 328, the pipe 328 comprises a high-pressure nozzle orifice, the nozzle orifice along the axis of the guide pressure jet 350 J, the axis J relative to the longitudinal axis of the catheter 312 defines a K an angle of about 90 degrees β. 导管212和312中的每一个均包括未示出的注入管腔,所述注入管腔与包括在导管12中的注入管腔32相似。 Catheter 212 and 312 each include a lumen (not shown) injected into the injection lumen comprises injection lumen 32 of the catheter 12 is similar.

[0089] 图15和16图解了整体用412示出的公开的血栓切除术导管的又一个替代实施例。 [0089] Figures 15 and 16 illustrate the overall disclosure illustrated thrombus ablation catheter 412 with still another alternative embodiment. 导管412包括环形注入管腔432、中央排放管腔430和高压供应管428。 An annular injection conduit 412 includes a lumen 432, a central lumen 430 and high pressure supply discharge pipe 428. 供应管428包括限定了喷嘴440a的弯曲部分440。 Defining a supply pipe 428 including a bent portion 440 of the nozzle 440a. 喷嘴440a定位成将流体射流450引导到排放管腔430的远端中。 440a nozzle 450 positioned to guide the fluid jet lumen 430 to the distal end of the discharge. 如所图解的那样,导管412可以与高压管428形成整体。 As illustrated above, the catheter 412 may be integrally formed with the high-pressure pipe 428. 尽管没有示出,可以在高压管428的远端处设置更加刚性的弯曲部分440,以便防止因喷射射流450所造成的弯曲部分440的偏斜。 Although not shown, a more rigid bent portion 440 disposed at the distal end of the high-pressure pipe 428, in order to prevent deflection of the jet by the injector 450 caused by the bent portion 440.

[0090] 图17和18图解了整体用512示出的血栓切除术导管的再一个替代实施例。 [0090] Figures 17 and 18 illustrate a whole by 512 and then thrombectomy shown an alternative embodiment of the catheter. 导管512包括导管体524,所述导管体524限定了排放管腔530、注入管腔532、和高压流体供应管腔528。 Catheter 512 comprises a catheter 524, the catheter body 524 defining a discharge lumen 530, into lumen 532, lumen 528 and high pressure fluid supply. 高压流体供应管腔528的远端包括弯曲部分540,所述弯曲部分540具有喷嘴喷口540a。 The distal end of the high pressure fluid supply lumen 528 includes a curved portion 540, the curved portion 540 has a nozzle orifice 540a. 喷嘴喷口540a定位成将流体射流550引导到排放管腔530的远端中。 Nozzle orifices 540a positioned to guide the fluid jet 550 to the distal end 530 of the discharge lumen. 如所图解的那样,与导管412的定位成环绕导管体424的注入管腔432相比,注入管腔532居中布置在导管体524中。 As illustrated above, the conduit 412 is positioned to surround the injection lumen of the catheter body 424 compared to 432, 532 centrally disposed in the injection lumen catheter body 524.

[0091] 除了各种管腔的不同定向和构造之外,可以以与图1-8中示出的先前实施例相似的方式构造和操作图15-18中示出的实施例。 Constructed and operative embodiment is similar to the previous embodiment of FIG. [0091] In addition to a variety of different orientations and configurations of the lumen, it may be shown in FIGS. 1-8 and 15-18 in the illustrated embodiment. 注入管腔432、532的变化提供了在0°和360°之间变化注入管腔围绕排放管腔的角度范围的能力。 Change injection lumen 432, 532 provide the ability to between 0 ° and 360 ° angle around the injection lumen variation range of the discharge lumen. 而且,在图17-18中示出的注入管腔532提供了紧邻切除射流550的注入。 Further, in the illustrated figures 17-18 injection lumen 532 is provided adjacent to the injection jet 550 is cut. 最大化角度范围保证了用于最大化注入流体再循环的装置,这继而最小化了从体腔中吸出血液的量。 Range of angles ensures that maximize fluid recirculation means for injecting maximized, which in turn minimizes the amount of sucked out from the body cavity of blood.

[0092] 图19图解了整体用612示出的公开的血栓切除术导管的替代实施例。 [0092] FIG. 19 illustrates a whole by 612 discloses a thrombus resection shown an alternative embodiment of a catheter. 导管612与导管12相似并且包括限定了排放管腔630、注入管腔632和高压流体供应管腔628的导管体624。 12 is similar to catheter 612 and the catheter includes a lumen 630 defining a discharge, a high-pressure injection fluid supply lumen 632 and lumen 628 of the catheter body 624. 高压流体供应管腔628的远端包括具有喷嘴喷口640a的弯曲部分640。 The distal end of the high pressure fluid supply lumen 628 includes a curved portion 640 having a nozzle orifice 640a. 喷嘴喷口640a定位成引导高压流体进入到排放管腔630中。 Nozzle orifices 640a positioned to direct high pressure fluid into the exhaust lumen 630.

[0093] 排放管腔630包括分隔壁660,所述分隔壁660将排放管腔630分成第一和第二排放管腔段630a和630b。 [0093] The exhaust lumen 630 includes a partition wall 660, the partition wall 660 and exhaust lumen 630 into a first segment 630a and a second exhaust lumen 630b. 第一排放管腔段630a包括通道662,所述通道662使吸入到第一排放管腔段630a中的流体的一部分能够沿着用箭头“X”表示的方向再循环回到体腔中。 A first exhaust lumen section 630a includes a channel 662, the fluid passage 662 to the suction lumen of the first section 630a of the discharge portion can be recycled back to the direction by arrow "X" represents a body cavity. 过滤器666设置在第一排放管腔段630a的入口处,以便防止固体颗粒(诸如,闭塞材料和固体血液成分)进入到第一排放管腔段630a中。 A first filter 666 disposed at the entrance to the discharge lumen section 630a, so as to prevent the solid particles (such as occlusive material and the solid blood component) into a first segment 630a of the exhaust lumen. 在一个实施例中,过滤器666定位成成一定角度,以将从进入到第一排放管腔段630a的流体中过滤出的固体颗粒引导到第二排放管腔段630b中。 In one embodiment, the filter 666 is positioned at an angle to the discharge from the lumen into the first section 630a of the filtered fluid solid particles directed to the second section 630b of the exhaust lumen. 如以上关于图1示出的系统10讨论的那样,排放管腔段630a和630b中的每一个的近端均与排放贮存器(诸如,贮存器18)连通。 10 As discussed above with respect to FIG. 1 as system shown, each of the exhaust lumen proximal sections 630a and 630b of both (such as a reservoir 18) in communication with the discharge reservoir.

[0094] 在图20中整体用712示出的公开的血栓切除术导管的另一个实施例中,设置了第二再循环通道770,如将在下文中更加详细描述的那样。 Another [0094] The entire disclosure of thrombi by 712 shown in FIG. Ablation catheter 20 embodiment, the second recirculation passage 770 is provided, as will be described in more detail below. 导管712包括主体724,所述主体724限定了:排放管腔730 ;注入管腔(未示出);和高压流体供应管腔728,所述高压流体供应管腔728包括具有喷嘴喷口740a的弯曲部分740。 The catheter 712 includes a body 724, the body 724 defines a: exhaust lumen 730; injection lumen (not shown); and a high pressure fluid supply lumen 728, the high pressure fluid supply lumen 728 includes a nozzle 740a of the curved spout section 740. 排放管腔730包括分隔壁760,所述分隔壁760将排放管腔730分成第一和第二排放管腔段730a和730b。 Exhaust lumen 730 includes a partition wall 760, the partition wall 760 and exhaust lumen 730 into a first segment 730a and a second exhaust lumen 730b. 第一过滤器766定位在第一排放管腔段730a的远端中。 The first filter 766 is positioned at the distal end of the first section 730a of the exhaust lumen in. 第一过滤器766与过滤器666相似并且防止固体颗粒进入到第一排放管腔段730a中并且防止所述固体颗粒通过再循环通道762。 The first filter 766 is similar to the filter 666 and prevent solid particles from entering the first exhaust lumen segment 730a and prevents the solid particles through the recirculation channel 762. 再循环通道762使进入到第一排放管腔段730a中的流体的一部分回到患者的体腔内。 Recirculation passage 762 so that a portion of the lumen fluid into a first segment 730a of the exhaust back into the patient's body cavity. 导管712与导管612的不同之处在于过滤器766没有成一定角度、而是延伸横跨第一排放管腔段730a(尽管过滤器766可以成一定角度),并且不同之处在于第二再循环通道770使离开第二排放管腔段730b的流体的一部分再循环进入到高压流体供应管腔728中。 Conduit 712 and conduit 612 except that the filter 766 is not an angle, but the exhaust lumen extending across the first section 730a (although the filter 766 may be angled), and the second recirculation except that a portion of the recirculation channel 770 exiting the second fluid exhaust lumen segment 730b of the high pressure fluid into the lumen 728. 第二过滤器772定位在再循环通道770中。 The second filter 772 is positioned in the recirculation channel 770. 在一个实施例中,第二过滤器772的网眼大小允许流体和非常小的固体颗粒(例如小于0.0005英寸)进入到供应管腔728中。 In one embodiment, the mesh size of the second filter 772 allows fluid and very small solid particles (e.g. less than 0.0005 inches) into the supply lumen 728. 更加具体地,固体颗粒的尺寸应当至少为小于喷嘴喷口直径的数量级。 More specifically, the size of the solid particles should be at least smaller than the diameter of the nozzle orifice of magnitude. 通过使小固体颗粒进入到高压供应管腔728中,能够由喷嘴喷口740a实现类喷砂效应,以更加有效地从体腔中移除闭塞材料。 By making small solid particles into the high pressure supply lumen 728, 740a can be achieved by a class effect blasting nozzle orifice, to more efficiently remove occlusive material from the body cavity. 尽管没有示出,但是导管712可以设置有再循环通道770和762中的仅仅一个。 Although not shown, the conduit 712 may be provided with a recirculation passage 770 and 762 only one. 另外,尽管公开的是将固体颗粒从排放管腔730供应到高压供应管腔728中,但是可以设想的是将固体颗粒直接从高压流体源16供应到高压供应管腔728 (图1)。 Further, although the disclosed solid particles is discharged from the supply to the high pressure supply lumen 730 lumen 728, but it is contemplated that the solid particles are supplied directly from the high pressure fluid source 16 to the high pressure supply lumen 728 (FIG. 1). [0095] 图21图解了整体用812示出的公开的血栓切除术导管的另一个实施例。 [0095] FIG. 21 illustrates another integral with the disclosed thrombus 812 illustrated ablation catheter embodiment. 导管812包括导管体824,所述导管体824限定了排放管腔830和注入管腔832并且具有高压流体供应管腔828。 Catheter 812 comprises a catheter 824, the catheter body 824 defining a lumen 830 and exhaust lumen 832 and injection fluid supply lumen 828 having a high pressure. 高压流体供应管腔828包括具有喷嘴喷口840a的弯曲部分840,所述喷嘴喷口840a定位成将高压流体引导到排放管腔830中。 The high pressure fluid supply lumen 828 includes a curved portion 840a of the spout 840 with a nozzle, the nozzle orifice 840a positioned to discharge high pressure fluid into the lumen 830.

[0096] 血栓切除术导管812包括位于排放管腔830中用于破碎闭塞材料的浸溃结构876。 [0096] thrombectomy catheter 812 includes a lumen 830 for discharge breaking occluding material impregnated structure 876. 这有助于防止闭塞材料堵塞排放管腔830。 This helps prevent clogging of exhaust lumen 830 occlusive material. 浸溃结构876可以包括具有锋利切割边缘的部件,诸如格栅或穿孔板,所述部件定位成破碎吸入到排放管腔830中的闭塞材料。 Dipping structure 876 may include a member having a sharpened cutting edge, such as a grid or perforated plate, the crushing member is positioned to discharge the suction lumen 830 occluding material. 可替代地,浸溃结构876可以具有多种构造,所述构造包括响应流过排放管腔830的流体流量的可旋转涡轮或研磨件,或者定位在排放管腔830的壁内或者沿着排放管腔830的壁定位的一系列具有研磨作用的突出件。 Alternatively, the impregnated structure 876 may have various configurations, including the configuration in response to fluid flow through the exhaust lumen 830 may be a turbine or rotary grinding member positioned in the wall or exhaust lumen 830, or along the discharge positioning the lumen wall 830 having a series of projecting abrasive action.

[0097] 图22图解了整体用血栓切除术导管912示出的公开的血栓切除术导管的又一个实施例。 [0097] FIG. 22 illustrates a whole by thrombus disclosed thrombectomy catheter 912 illustrated ablation catheter in yet another embodiment. 血栓切除术导管912包括导管体924,所述导管体924限定了排放管腔930和注入管腔932并且具有包括弯曲部分940和喷嘴940a的高压流体供应管腔928。 Thrombectomy catheter 912 includes a catheter 924, the catheter body 924 defining a lumen 930 and exhaust lumen 932 and injection with a high pressure fluid supply includes a curved portion 940 and the lumen 928 of the nozzle 940a. 防损伤尖端960定位在血栓切除术导管912的远端的周围并且限定了位于喷嘴940a和排放管腔930的入口之间的窗口980。 Atraumatic tip 960 is positioned around the distal end of the catheter 912 thrombectomy and defining a window between the inlet 940a of the nozzle 930 and exhaust lumen 980. 诸如笼状物或筛状结构的分离装置982定位在窗口980上。 Separation means such as a cage or a mesh-like structure 982 is positioned on the window 980. 分离装置982最小化了将被抽吸到切除窗口980中的组织数量,以便最小化因血管壁与流体射流950相接触导致的损伤血管壁的可能性。 Separating means 982 minimizes the amount of tissue to be drawn into the cutting window 980, so as to minimize the possibility of vessel wall damage caused by the vessel wall 950 in contact with the fluid jet. 尽管没有示出,但是分离装置982可以滑动地定位在导管912周围或者定位在导管912内,使得分离装置982可以选择性定位在窗口980上或者运动离开窗口980。 Although not shown, the separating apparatus 982 is slidably positioned around the catheter is positioned within the conduit 912 or 912, so that the separation apparatus 982 can be selectively positioned on the window 980 or 980 is moved away from the window.

[0098] 本领域的技术人员将理解的是,本文具体描述和附图具体图解的装置和方法并非限制性的示例实施例。 [0098] Those skilled in the art will be appreciated that the example apparatus and methods specifically described herein and illustrated in the accompanying drawings are not limiting examples. 可以设想的是,在不背离本公开的范围的前提下,结合一个示例性实施例图解或描述的元件和特征可以与另一个示例性实施例的元件和特征组合。 It is contemplated that, without departing from the scope of the present disclosure premise, a binding elements and features illustrated or described embodiments may be combined with elements and features of another exemplary embodiment of the exemplary embodiment. 例如,关于图2中示出的血栓切除术导管12所描述的传感器80a-80c也能够包括在在此描述的血栓切除术导管中的任意一个中。 For example, in FIG. 2 on thrombosis illustrated ablation catheter 12 sensors 80a-80c described herein also can be included in the thrombus resection described herein in any of a catheter. 而且,本领域的技术人员将根据上述实施例理解本公开的其它特征和优势。 Moreover, those skilled in the art will appreciate further features and advantages of the present disclosure according to the above embodiment. 因此, 除了由随附权利要求所表示的那些内容,本公开并不局限于已经具体示出并且描述的内容。 Thus, in addition to those elements represented by the appended claims, the present disclosure is not limited to what has been particularly shown and described hereinabove.

Claims (23)

1. 一种血栓切除术导管系统,所述血栓切除术导管系统包括: 导管,所述导管包括导管体并且包括高压管,所述导管体限定了排放管腔和注入管腔,所述高压管具有定位成将流体射流引导到所述排放管腔的远侧开口中的喷嘴喷口; 注入流体源,所述注入流体源与所述注入管腔的近端连通;和流体控制装置,所述流体控制装置流体联接在所述血栓切除术导管和所述注入流体源之间,所述流体控制装置适于调节从所述注入流体源注入到所述血栓切除术导管的注入管腔的注入流体的流速。 A thrombectomy catheter system, the thrombectomy catheter system comprising: a catheter comprising a catheter body and includes a high-pressure pipe, the exhaust lumen catheter body defining a lumen and injection, the high-pressure pipe having positioned to direct a jet of fluid into the lumen distal opening in the discharge orifice of the nozzle; injecting a fluid source, the source and the injection fluid injection lumen in communication with the proximal end; and a fluid control device, the fluid fluid control means coupled between the thrombectomy catheter and the source of injection fluid, the fluid control means is adapted to adjust the injection fluid is injected from the source to the injection fluid injection thrombectomy catheter lumen of flow rate.
2.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括与所述高压管连通的高压流体源,所述高压流体源以大约IOOpsi和大约10,OOOpsi之间的压力将高压流体供应到所述高压管。 The I according to thrombectomy catheter system, said system further thrombectomy catheter includes a high pressure fluid source in communication with the high-pressure pipe, the high pressure fluid source as claimed in claim IOOpsi about and about 10, OOOpsi between the high-pressure fluid pressure supplied to the high-pressure pipe.
3.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括基本上刚性的定位带,所述定位带固定到所述导管体的远端,所述定位带限定了与所述导管体的排放管腔连通的排放管腔和与所述导管体的注入管腔连通的注入管腔。 The I according to thrombectomy catheter system, the thrombectomy catheter system further comprises a substantially rigid positioning with the positioning of the distal end of the catheter body is fixed to the band, the band is defined positioning claims the exhaust lumen and the discharge lumen of the catheter body and communicating with the injection lumen of the catheter body in communication with the injection lumen.
4.根据权利要求3所述的血栓切除术导管系统,其中,所述高压管结合到所述定位带。 According to claim 3, wherein said thrombus ablation catheter system, wherein the pressure pipe is coupled to the positioning belt.
5.根据权利要求3所述的血栓切除术导管系统,其中,所述高压管延伸通过所述导管体的注入管腔和所述定位带的注入管腔。 Thrombosis according to claim 3, said ablation catheter system, wherein the high-pressure pipe extending through the injection lumen and the injection lumen positioned with the catheter body.
6.根据权利要求I所述的血栓切除术导管系统,其中,所述流体控制装置包括可调节阀,所述可调节阀适于调节从所述注入流体源注入到所述血栓切除术导管的注入管腔的注入流体流速。 The thrombectomy catheter system according to claim I, wherein the fluid control means comprises an adjustable valve, the adjustable valve adapted to adjust the injection fluid is injected from the source to the thrombectomy catheter the flow rate of injection fluid injection lumen.
7.根据权利要求6所述的血栓切除术导管系统,其中,所述可调节阀适于周期性变化注入到所述血栓切除术导管的注入流体的流速。 The thrombus ablation catheter of the system 6, wherein the adjustable valve adapted to periodically change the injection flow rate of the injection fluid thrombectomy catheter claims.
8.根据权利要求I所述的血栓切除术导管系统,其中,所述流体控制装置包括流体泵,所述流体泵用于从所述注入流体源将注入流体周期性供应到所述血栓切除术导管。 I according to the thrombectomy catheter system of claim, wherein the fluid control means comprises a fluid pump, the fluid pump for injecting a fluid from the source to the injection fluid supply periodically thrombectomy catheter.
9.根据权利要求I所述的血栓切除术导管系统,其中,所述血栓切除术导管还包括防损伤尖端,所述防损伤尖端包括:一对注入通道,所述注入通道与所述定位带的注入管腔连通;和贮存器,所述贮存器用于接收所述高压管,所述贮存器具有上开口。 According to claim I of the thrombectomy catheter system wherein the thrombectomy catheter further comprises an atraumatic tip, said atraumatic tip comprising: a pair of injection channel, said injection channel with the positioning injection lumen in communication; and the reservoir, the reservoir for receiving the high-pressure pipe, the reservoir having an upper opening.
10.根据权利要求9所述的血栓切除术导管系统,其中,所述注入通道在所述高压管的弯曲部分的远侧延伸。 According to claim 9 thrombus ablation catheter system, wherein the injection channel extending in the distal curved portion of the high-pressure pipe.
11.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括引导导管,所述引导导管限定了:引导管腔,所述引导管腔的尺寸设计成接收所述血栓切除术导管;近侧球囊和远侧球囊。 According to claim I of the thrombectomy catheter system, said system further thrombectomy catheter includes a guide catheter, said guide catheter defines: a guide lumen, said guide lumen sized to receive the thrombectomy catheter; proximal balloon and a distal balloon.
12.根据权利要求11所述的血栓切除术导管系统,其中,所述引导导管的位于所述近侧球囊和所述远侧球囊之间的部分具有正弦形状并且限定了多个开口,所述多个开口提供了进入到所述血栓切除术导管的途径。 11 12. The thrombus ablation catheter system according to claim, wherein the guide catheter is located proximal of the balloon and the distal portion has a sinusoidal shape and a plurality of openings defined between the balloons, the plurality of openings provides a way to enter the thrombectomy catheter.
13.根据权利要求11所述的血栓切除术导管系统,其中,所述引导导管的位于所述近侧球囊和所述远侧球囊之间的部分具有柔性并且限定了多个开口,所述多个开口提供了进入到所述血栓切除术导管的途径,所述引导导管的所述部分的柔性使得一旦将所述血栓切除术导管插入到所述引导导管中所述引导导管就呈现赋予所述血栓切除术导管的正弦形状。 11 13. The thrombus ablation catheter system according to claim, wherein said guide portion is located between said conduit and said proximal balloon having a flexible distal balloon and defining a plurality of openings, the said plurality of openings providing the entry way to the thrombectomy catheter, the flexible portion of the guide catheter such that once the thrombectomy catheter into the guide catheter into the guide catheter to impart presentation the thrombectomy catheter of the sinusoidal shape.
14.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括传感器,所述传感器构造成测量体腔内的压力。 I claim 14. The thrombectomy catheter system, the thrombectomy catheter system of claim 1 further comprising a sensor configured to measure pressure in the body cavity.
15.根据权利要求14所述的血栓切除术导管系统,其中,所述传感器构造成控制所述流体控制装置的操作。 Thrombosis according to claim 14, said ablation catheter system, wherein the sensor is configured to control the operation of the fluid control device.
16.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括再循环通道,所述再循环通道定位成使流体从所述排放管腔内再循环回到体腔中。 According to claim I of the thrombectomy catheter system, the thrombectomy catheter system further comprises a recirculation passage, the recirculation passage positioned to discharge the fluid from the inner lumen of recycled back into the body cavity .
17.根据权利要求16所述的血栓切除术导管系统,所述血栓切除术导管系统还包括过滤器,所述过滤器定位在所述再循环通道的上游处,所述过滤器的尺寸设计成防止固体颗粒进入到所述再循环通道中。 Thrombosis according to claim 16, said ablation catheter system, the thrombectomy catheter system further comprising a filter, said filter positioned upstream of said recirculation passage, the size of the filter is designed to to prevent solid particles from entering said recirculation passage.
18.根据权利要求17所述的血栓切除术导管系统,其中,所述排放管腔被分隔壁分成第一排放管腔段和第二排放管腔段,并且所述过滤器和所述再循环通道定位在所述第一排放管腔段中。 Thrombosis according to claim 17, said ablation catheter system, wherein the discharge lumen wall is divided into a first section and a second exhaust lumen lumen discharge section, and the filter and the recirculation a first channel positioned in the exhaust lumen section.
19.根据权利要求18所述的血栓切除术导管系统,其中,所述过滤器定位在所述第一排放管腔段的一个端部处并且成一定角度,以将固体颗粒引导到所述第二排放管腔段中。 19. The claim 18 of the thrombus ablation catheter system, wherein the filter is positioned at a discharge end of the first lumen and the angled segment to the solid particles into said first in two sections the discharge lumen.
20.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括浸溃结构,所述浸溃结构定位在所述排放管腔内并且构造成破碎闭塞材料。 I claim 20. The thrombectomy catheter system, the thrombectomy catheter system further comprises a structure as claimed in claim dipping, the impregnated structure is positioned within the exhaust lumen and configured to break occlusion material.
21.根据权利要求20所述的血栓切除术导管系统,其中,所述浸溃结构包括具有锋利切割边缘的格栅。 21. The thrombus said ablation catheter system of claim 20, wherein said impregnated structure comprising a grid having a sharp cutting edge.
22.根据权利要求20所述的血栓切除术导管系统,其中,所述浸溃结构包括构造成研磨闭塞材料的能够旋转的涡轮。 22. The thrombus ablation catheter of the system 20, wherein the impregnated structure comprises a rotatable turbine configured abrasive material of claim occlusion.
23.根据权利要求I所述的血栓切除术导管系统,所述血栓切除术导管系统还包括主体,所述主体限定了:切除窗口,所述切除窗口位于所述喷嘴喷口和所述排放管腔的入口之间;和分离装置,所述分离装置定位成毗邻所述窗口,以覆盖所述窗口,其中,所述分离装置构造成最小化进入所述切除窗口的组织的数量。 I claim 23. The thrombectomy catheter system, the thrombectomy catheter system as claimed in claim further comprising a body defining: the cutting window, the window is in the cutting nozzle and the discharge spout lumen between the inlet; and the separating means, the separating means is positioned adjacent the window to cover the window, wherein said separating means is configured to enter the number of the tissue cutting window is minimized.
CN 201310028600 2012-01-26 2013-01-25 Thrombectomy catheter system CN103251440B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105214199A (en) * 2014-07-01 2016-01-06 上海理工大学 Partial-sealing reverse-flow type blood clot resorption device

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9782195B2 (en) * 2013-11-20 2017-10-10 Board Of Regents Of The University Of Nebraska Fluid jet arterial surgical device
US9248221B2 (en) 2014-04-08 2016-02-02 Incuvate, Llc Aspiration monitoring system and method
US9433427B2 (en) 2014-04-08 2016-09-06 Incuvate, Llc Systems and methods for management of thrombosis
KR20170039753A (en) * 2014-08-14 2017-04-11 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 Systems and methods for cleaning an endoscopic instrument
US20170274125A1 (en) * 2015-07-13 2017-09-28 Integrated Surgical LLC Surgical suction device that uses positive pressure gas
WO2017177068A1 (en) * 2016-04-06 2017-10-12 Integrated Surgical LLC Surgical suction device that uses positive pressure gas

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2049956U (en) * 1989-07-28 1989-12-27 王东亚 Guide tube for removing thrombus in blood vessel
WO1990005493A1 (en) * 1988-11-15 1990-05-31 Svedman Paal Surgical instrument
EP0485133A1 (en) * 1990-11-08 1992-05-13 Possis Medical, Inc. Asymmetric water jet atherectomy
US5318518A (en) * 1991-08-14 1994-06-07 Hp Medica Gesellschaft Mbh Fur Medizintechnische Systeme Irrigating catheter
US6258061B1 (en) * 1990-08-06 2001-07-10 Possis Medical, Inc. Thrombectomy and tissue removal device
WO2001076518A1 (en) * 2000-04-07 2001-10-18 Surgijet, Inc. Method and apparatus for thermal emulsification
CN101394877A (en) * 2006-01-24 2009-03-25 海德鲁西昂公司 Liquid jet surgical instrument having a distal end with a selectively controllable shape
CN101460101A (en) * 2006-04-25 2009-06-17 海德鲁西昂公司 Electroformed liquid jet surgical instrument
US20090192498A1 (en) * 2007-04-30 2009-07-30 Andrew Mark S Liposuction of visceral fat using tissue liquefaction
CN101730507A (en) * 2007-03-30 2010-06-09 泰科医疗集团有限合伙公司 Methods and apparatus for thrombectomy system
CN102319097A (en) * 2011-08-04 2012-01-18 东莞永胜医疗制品有限公司 Thrombus aspiration catheter and using method thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487600A (en) * 1981-11-09 1984-12-11 Brownlie Alan W Adjustable suction device for medical use
US4694828A (en) * 1986-04-21 1987-09-22 Eichenbaum Daniel M Laser system for intraocular tissue removal
EP0318042B2 (en) * 1987-11-27 1996-09-04 Lorenzo Molinari Adjustable apparatus for removing surface portions of human tissue
US5052624A (en) * 1988-03-11 1991-10-01 Possis Corporation Ultra high pressure water cleaning tool
US4937985A (en) 1989-09-25 1990-07-03 Possis Corporation Abrasive waterjet receiver
US5037431A (en) * 1989-11-03 1991-08-06 The Curators Of The University Of Missouri Surgical liquid lance apparatus
US5018670A (en) 1990-01-10 1991-05-28 Possis Corporation Cutting head for water jet cutting machine
NL9000356A (en) * 1990-02-14 1991-09-02 Cordis Europ Drainage catheter.
US6984239B1 (en) 1990-08-06 2006-01-10 Possis Medical, Inc. Thrombectomy and tissue removal method
CA2321221A1 (en) 1999-10-13 2001-04-13 Debra M. Kozak Crossflow thrombectomy catheter and system
US6676627B1 (en) 1990-08-06 2004-01-13 Possis Medical, Inc. Crossflow thrombectomy catheter and system
US5300022A (en) * 1992-11-12 1994-04-05 Martin Klapper Urinary catheter and bladder irrigation system
US5855549A (en) * 1993-08-18 1999-01-05 Vista Medical Technologies, Inc. Method of using an optical female urethroscope
US6135977A (en) 1994-02-16 2000-10-24 Possis Medical, Inc. Rheolytic catheter
US5871462A (en) 1995-06-07 1999-02-16 Hydrocision, Inc. Method for using a fluid jet cutting system
US6216573B1 (en) 1995-06-07 2001-04-17 Hydrocision, Inc. Fluid jet cutting system
US6676637B1 (en) * 1998-02-06 2004-01-13 Possis Medical, Inc. Single operator exchange fluid jet thrombectomy method
US6224570B1 (en) 1998-02-06 2001-05-01 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
US5989210A (en) 1998-02-06 1999-11-23 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
US6875193B1 (en) 1998-02-06 2005-04-05 Possis Medical, Inc. Rapid exchange fluid jet thrombectomy device and method
US7226433B2 (en) 1998-02-06 2007-06-05 Possis Medical, Inc. Thrombectomy catheter device having a self-sealing hemostasis valve
US5989271A (en) * 1998-11-09 1999-11-23 Possis Medical, Inc. Flexible tip rheolytic thrombectomy catheter and method of constructing same
US6375635B1 (en) 1999-05-18 2002-04-23 Hydrocision, Inc. Fluid jet surgical instruments
US6193589B1 (en) * 1999-06-21 2001-02-27 Ben M. Khalaj Hand piece apparatus for abrasive cleaning devices
WO2001049341A3 (en) * 1999-12-31 2002-01-17 Bacchus Vascular Inc Method and system for re-infusing filtered bodily aspirates
US6451017B1 (en) 2000-01-10 2002-09-17 Hydrocision, Inc. Surgical instruments with integrated electrocautery
US6511493B1 (en) 2000-01-10 2003-01-28 Hydrocision, Inc. Liquid jet-powered surgical instruments
US6929633B2 (en) * 2000-01-25 2005-08-16 Bacchus Vascular, Inc. Apparatus and methods for clot dissolution
EP1384003B1 (en) 2001-04-27 2007-07-18 HydroCision, Inc. High pressure pumping cartridges for medical and surgical pumping and infusion applications
US6712757B2 (en) * 2001-05-16 2004-03-30 Stephen Becker Endoscope sleeve and irrigation device
JP2004537380A (en) 2001-08-08 2004-12-16 ハイドロシジョン・インコーポレーテッド Medical device with a high-pressure rapid separation handpiece
US6932828B2 (en) 2001-11-06 2005-08-23 Possis Medical, Inc. Guidewire occlusion system utilizing repeatably inflatable gas-filled occlusive device
US7220243B2 (en) 2001-11-06 2007-05-22 Possis Medical, Inc. Gas inflation/evacuation system and sealing system incorporating a compression sealing mechanism for guidewire assembly having occlusive device
US6942678B2 (en) 2001-11-06 2005-09-13 Possis Medical, Inc. Gas inflation/evacuation system and sealing system for guidewire assembly having occlusive device
US7169161B2 (en) 2001-11-06 2007-01-30 Possis Medical, Inc. Guidewire having occlusive device and repeatably crimpable proximal end
DE60221294T2 (en) 2001-11-21 2008-04-03 HydroCision, Inc., Billerica Surgical liquid jet instruments along the beamformed channel openings
US8162966B2 (en) 2002-10-25 2012-04-24 Hydrocision, Inc. Surgical devices incorporating liquid jet assisted tissue manipulation and methods for their use
US7033317B2 (en) 2003-06-05 2006-04-25 Hydrocision, Inc. Disposable endoscope and method of making a disposable endoscope
US7220269B1 (en) 2003-11-06 2007-05-22 Possis Medical, Inc. Thrombectomy catheter system with occluder and method of using same
WO2006066160A9 (en) 2004-12-14 2006-08-10 Hydrocision Inc Liquid jet surgical instrument
US8647294B2 (en) * 2008-03-20 2014-02-11 Medrad, Inc. Direct stream hydrodynamic catheter system

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005493A1 (en) * 1988-11-15 1990-05-31 Svedman Paal Surgical instrument
CN2049956U (en) * 1989-07-28 1989-12-27 王东亚 Guide tube for removing thrombus in blood vessel
US6258061B1 (en) * 1990-08-06 2001-07-10 Possis Medical, Inc. Thrombectomy and tissue removal device
EP0485133A1 (en) * 1990-11-08 1992-05-13 Possis Medical, Inc. Asymmetric water jet atherectomy
US5496267A (en) * 1990-11-08 1996-03-05 Possis Medical, Inc. Asymmetric water jet atherectomy
US5318518A (en) * 1991-08-14 1994-06-07 Hp Medica Gesellschaft Mbh Fur Medizintechnische Systeme Irrigating catheter
WO2001076518A1 (en) * 2000-04-07 2001-10-18 Surgijet, Inc. Method and apparatus for thermal emulsification
CN101394877A (en) * 2006-01-24 2009-03-25 海德鲁西昂公司 Liquid jet surgical instrument having a distal end with a selectively controllable shape
CN101460101A (en) * 2006-04-25 2009-06-17 海德鲁西昂公司 Electroformed liquid jet surgical instrument
CN101730507A (en) * 2007-03-30 2010-06-09 泰科医疗集团有限合伙公司 Methods and apparatus for thrombectomy system
US20090192498A1 (en) * 2007-04-30 2009-07-30 Andrew Mark S Liposuction of visceral fat using tissue liquefaction
CN102319097A (en) * 2011-08-04 2012-01-18 东莞永胜医疗制品有限公司 Thrombus aspiration catheter and using method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105214199A (en) * 2014-07-01 2016-01-06 上海理工大学 Partial-sealing reverse-flow type blood clot resorption device

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