CN103235027A - Electrophoresis system compaction device - Google Patents
Electrophoresis system compaction device Download PDFInfo
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- CN103235027A CN103235027A CN201310134081XA CN201310134081A CN103235027A CN 103235027 A CN103235027 A CN 103235027A CN 201310134081X A CN201310134081X A CN 201310134081XA CN 201310134081 A CN201310134081 A CN 201310134081A CN 103235027 A CN103235027 A CN 103235027A
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- slide block
- driving wheel
- hollow slide
- contact roller
- down gag
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Abstract
The invention relates to an electrophoresis system compaction device comprising a plurality of cross beams and pressing rods pressed at two ends of each cross beam. Each pressing rod is connected with a pressing rod driving mechanism. The pressing rod driving mechanism comprises a worm driven by a driving wheel. The worm drives a worm wheel. Each of the two ends of the output shaft of the worm wheel is respectively connected to a bevel gear. Each bevel gear drives another output shaft through another bevel gear. A set of eccentrically connected compaction wheels are arranged on each output shaft. A hollow slide block is arranged outside the compaction wheel. A supporting rack is arranged outside the hollow slide block. The supporting rack is connected on the supporting plate of the electrophoresis system. The supporting rack is provided with a guide hole. A guide column inserting in the corresponding guide hole is arranged on the hollow slide block. A through hole is provided on the top of the supporting rack. A calibration nut is inserted into the through hole. A thread column is arranged on the top of the hollow slide block. The upper end of the calibration nut is hinged with the bottom of the pressing rod through a screw. The device provided by the invention has the advantages of simple structure and easy operation, and can be widely applied in various free-flow electrophoresis systems.
Description
Technical field
The present invention relates to a kind of hold down gag, particularly a kind of hold down gag of electrophoresis system.
Background technology
In order to reduce convection current influence and the molecule sedimentation that is brought by acceleration of gravity, ground free flow electrophoresis system generally is to carry out in the thin layer liquid phase.Because the shaping of the ultra-thin cavity of electrophoresis system depends on pad, in ultra-thin cavity, do not allow any hardware except electrode to exist again, so pad can only be selected the stronger organic pad of inertia for use.And the elastic modulus of organic material has determined it can produce self-deformation when being squeezed, namely in certain scope, can adjust the depth of parallelism between disengagement chamber top board and the disengagement chamber substrate, but, if disengagement chamber top board and disengagement chamber substrate exceed above-mentioned setting range in the form and position tolerance that adds the generation in man-hour, the nonparallelism that physical dimension causes between disengagement chamber top board and the disengagement chamber substrate then, to directly cause the density variation of cavity inner laminar flow, cause natural convection, cause separating failure.
At present both at home and abroad nearly all free stream cataphoresis system all is the mode that adopts multiple spot to compress step by step, complex operation not only, and because operation requires harsh, carelessness is arranged slightly, very easily cause substrate local deformation by pressure is inhomogeneous, dielectric strength descends, and causes high-voltage breakdown.Therefore, in manufacture process, both required to guarantee the form and position tolerance of disengagement chamber, also required when operation cavity hold down gag that equilibrium keep-uped pressure.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide the hold down gag of the electrophoresis system of a kind of simple in structure, equalization of pressure, easy operating.
For achieving the above object, the present invention takes following technical scheme: a kind of hold down gag of electrophoresis system is characterized in that: it comprises hold-down mechanism, driving mechanism and intermediate connecting mechanism;
Described hold-down mechanism comprises the interval evenly and the some crossbeams that be arranged in parallel, the bottom interval of each described crossbeam is provided with at least two back-up blocks, the bottom of each described back-up block all is connected on the top board of free stream cataphoresis system disengagement chamber, and the two ends, top of each described crossbeam are provided with one and are pressed in depression bar on the described crossbeam by pressure head;
Described driving mechanism comprises a worm screw that is driven by driving wheel, described worm screw drives a worm gear, the central shaft two ends of described worm gear connect a conical gear respectively, each described conical gear drives an output shaft by another conical gear respectively, be arranged at intervals with one group of eccentric contact roller that connects on the two described output shafts respectively, the eccentric direction of each contact roller in two groups of described contact rollers is identical with eccentric distance;
Described intermediate connecting mechanism comprises a hollow slide block that is arranged on each described contact roller outside, the outside of each described hollow slide block is provided with a framework, each described framework is with respect to a described depression bar, and is fixedly connected on bottom support frame one side of free stream cataphoresis system; Described hollow slider top is provided with a threaded post, and the bottom is provided with a guidepost; Described base of frame is provided with the pilot hole of the described guidepost of an insertion, and the top is provided with a through hole, inserts a circular calibration nut in the described through hole, and the screw thread rotation direction at two ends is opposite in the described calibration nut; Described calibration nut top connects a screw rod, and the top of described screw rod connects described depression bar bottom by bearing pin; The threaded post of described hollow slider top is connected the bottom in the described calibration nut; Be arranged at intervals with some instruments on the circumference of described calibration nut middle part and insert blind hole, corresponding therewith, described framework is provided with the breach of insertion instrument.
The eccentric throw in the center of above-mentioned contact roller and the axle center of described output shaft is 1.2～2mm.
The eccentric throw in the center of above-mentioned contact roller and the axle center of described output shaft is 1.5mm.
The left and right sides stroke of above-mentioned contact roller in described hollow slide block is the described eccentric throw of twice, and the up and down stroke of described hollow slide block in described framework is the described eccentric throw of twice.
Above-mentioned driving wheel is provided with the spanner that the described driving wheel of a manual drive rotates.
Above-mentioned driving wheel is a follower gear, described follower gear engagement one driving gear by micro motor for driving.
The present invention is owing to take above technical scheme, it has the following advantages: 1, hold-down mechanism of the present invention is owing to take to arrange the even and parallel crossbeam in some intervals above free stream cataphoresis system disengagement chamber, and be fixed on each crossbeam on the top board of disengagement chamber by back-up block, one depression bar with pressure head is set respectively at the two ends of each crossbeam simultaneously, therefore when each depression bar bore downward pulling force, the pressure that disengagement chamber top board each several part is born was in admirable proportion.2, driving mechanism of the present invention is owing to adopt a driving wheel to drive two cover conical gear by a cover worm and gear, and by two output shafts that are respectively arranged with one group of eccentric contact roller of two cover conical gear drives, therefore when driving wheel during by manual or motorized motions, can drive all contact rollers rotates synchronously, not only can guarantee the equilibrium of exerting pressure, and greatly reduce the difficulty of operation.3, intermediate connecting mechanism of the present invention by hollow slide block absorption pressure bearing up pulley in horizontal eccentric rotary, off-centre contact roller is vertical by the calibration nut that moves up and down becomes the driving force that compresses and loosen depression bar, has solved the connectivity problem of driving mechanism and hold-down mechanism very dexterously.The present invention is simple in structure, and easy operating can be effectively be used for adjusting and the operating process of counterpressure of the disengagement chamber top board of free stream cataphoresis system.
Description of drawings
Fig. 1 is structural representation of the present invention
Fig. 2 is the synoptic diagram of partial structurtes of the present invention
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.
As shown in Figure 1, the present invention includes hold-down mechanism, driving mechanism and intermediate connecting mechanism.
Hold-down mechanism of the present invention comprises at interval evenly and is set in parallel in some crossbeams 2 of free stream cataphoresis system disengagement chamber 1 top, and the bottom of each crossbeam 3 all is connected with at least two back-up blocks 3, and the bottom of each back-up block 3 all is connected on the top board 4 of disengagement chamber 1; The two ends, top of each crossbeam 2 are provided with one and are pressed in depression bar 5 on the crossbeam 2 by pressure head.
As shown in Figure 2, driving mechanism of the present invention comprises a driving wheel 6, the projecting shaft 7 of driving wheel 6 drives a worm screw 8, worm screw 8 drives the worm gear 9 with its engagement, worm gear 9 central shaft 10 two ends connect a conical gear 11 respectively, each conical gear 11 drives an output shaft 13 by another conical gear 12, be arranged at intervals with one group of eccentric contact roller 14 that connects on two output shafts 13 respectively, the quantity of each group contact roller 14 is identical with the quantity of the crossbeam 2 of disengagement chamber 1 top, and the link position on output shaft 13 is also corresponding with the position of crossbeam 2, and the eccentric direction of two groups of contact rollers 14 on output shaft 13 is all identical with eccentric distance.Because two output shafts 13 are to be driven by same driving wheel 6, when therefore working, two output shafts 13 can drive two groups of contact rollers 14 and rotate relatively synchronously.
As shown in Figure 1 and Figure 2, intermediate connecting mechanism of the present invention comprises a hollow slide block 15 that is arranged on each contact roller 14 outside, the outside of each hollow slide block 15 is provided with a framework 16, the position of each framework 16 relative depression bar 5 is fixedly connected on the bracing frame 17 of electrophoresis system bottom one side.The bottom of each framework 16 is provided with a pilot hole, and the bottom of each hollow slide block 15 is provided with the guidepost 18 of the corresponding pilot hole of an insertion; The top of each framework 16 is provided with a through hole, inserts a circular calibration nut 19 in each through hole, and the screw thread rotation direction of upper/lower terminal is opposite in each calibration nut 19.The top of each hollow slide block 15 is provided with the threaded post 20 of a screw-in calibration nut 19, and the upper end of calibration nut 19 connects a screw rod 21, and the top of screw rod 21 is by the bottom-hinged of a bearing pin 22 with depression bar 5.Be arranged at intervals with some instruments at calibration nut 19 middle part circumference and insert blind hole 23, corresponding therewith, framework 16 is provided with the breach 24 of insertion instrument.
In above-described embodiment, the eccentric throw in the center of contact roller 14 and output shaft 13 axle center is scope of 1.2～2mm(PLSCONFM), embodiments of the invention are 1.5mm.Contact roller 14 left and right sides stroke in hollow slide block 15 is two times of eccentric throws of contact roller 14.Hollow slide block 15 in framework 16 up and down stroke be two times of eccentric throws of contact roller 14.
In above-described embodiment, the guidepost 18 of hollow slide block 15 bottoms and the threaded post 20 at top can also can adopt other convenient mode of installing to be connected on the hollow slide block 16 by being threaded on the hollow slide block 15.
In above-described embodiment, driving wheel 6 can connect a spanner, and rotating spanner just can drive driving mechanism and rotate.Also driving wheel 6 can be made into a follower gear, it meshes a driving gear, and driving gear can be driven driving mechanism equally and be rotated by a micro motor for driving.
The present invention is when Installation And Calibration, by adjusting threaded post 20 and the relative distance of screw rod 21 in calibration nut 18 in each calibration nut 19, realize the degree that compresses of 5 pairs of crossbeams 2 of depression bar, and then adjust the disengagement chamber top board 1 of electrophoresis system and the depth of parallelism between the disengagement chamber substrate 25.The present invention is when compressing, driving wheel 6 drives worm gear 9 by worm screw 8 and rotates, worm gear 9 is by the conical gear 11 at central shaft 10 drive two ends, and each conical gear 11 drives an output shaft 13 by another conical gear 12 with its engagement, drives one group of contact roller 14 respectively by two output shafts 13 and rotates; The rotation of each contact roller 14 of each group can drive hollow slide block 15 and move downward, and hollow slide block 15 moves downward by threaded post 19 drive screw rods 21 then, depression bar 5 is fitted with crossbeam 2 compress.The present invention only needs control driving wheel 6 to move round about and gets final product when unclamping.
The various embodiments described above only are used for explanation the present invention, and wherein the structure of each parts, connected mode etc. all can change to some extent, and every equivalents and improvement of carrying out on the basis of technical solution of the present invention all should do not got rid of outside protection scope of the present invention.
Claims (8)
1. the hold down gag of an electrophoresis system, it is characterized in that: it comprises hold-down mechanism, driving mechanism and intermediate connecting mechanism;
Described hold-down mechanism comprises the interval evenly and the some crossbeams that be arranged in parallel, the bottom interval of each described crossbeam is provided with at least two back-up blocks, the bottom of each described back-up block all is connected on the top board of free stream cataphoresis system disengagement chamber, and the two ends, top of each described crossbeam are provided with one and are pressed in depression bar on the described crossbeam by pressure head;
Described driving mechanism comprises a worm screw that is driven by driving wheel, described worm screw drives a worm gear, the central shaft two ends of described worm gear connect a conical gear respectively, each described conical gear drives an output shaft by another conical gear respectively, be arranged at intervals with one group of eccentric contact roller that connects on the two described output shafts respectively, the eccentric direction of each contact roller in two groups of described contact rollers is identical with eccentric distance;
Described intermediate connecting mechanism comprises a hollow slide block that is arranged on each described contact roller outside, the outside of each described hollow slide block is provided with a framework, each described framework is with respect to a described depression bar, and is fixedly connected on bottom support frame one side of free stream cataphoresis system; Described hollow slider top is provided with a threaded post, and the bottom is provided with a guidepost; Described base of frame is provided with the pilot hole of the described guidepost of an insertion, and the top is provided with a through hole, inserts a circular calibration nut in the described through hole, and the screw thread rotation direction at two ends is opposite in the described calibration nut; Described calibration nut top connects a screw rod, and the top of described screw rod connects described depression bar bottom by bearing pin; The threaded post of described hollow slider top is connected the bottom in the described calibration nut; Be arranged at intervals with some instruments on the circumference of described calibration nut middle part and insert blind hole, corresponding therewith, described framework is provided with the breach of insertion instrument.
2. the hold down gag of a kind of electrophoresis system as claimed in claim 1, it is characterized in that: the eccentric throw in the center of described contact roller and the axle center of described output shaft is 1.2～2mm.
3. the hold down gag of a kind of electrophoresis system as claimed in claim 2, it is characterized in that: the eccentric throw in the center of described contact roller and the axle center of described output shaft is 1.5mm.
4. as the hold down gag of a kind of electrophoresis system of claim 1 or 2 or 3, it is characterized in that: the left and right sides stroke of described contact roller in described hollow slide block is the described eccentric throw of twice, and the up and down stroke of described hollow slide block in described framework is the described eccentric throw of twice.
5. as the hold down gag of claim 1 or 2 or 3 described a kind of electrophoresis systems, it is characterized in that: described driving wheel is provided with the spanner that the described driving wheel of a manual drive rotates.
6. the hold down gag of a kind of electrophoresis system as claimed in claim 4 is characterized in that: described driving wheel is provided with the spanner that the described driving wheel of a manual drive rotates.
7. as the hold down gag of claim 1 or 2 or 3 described a kind of electrophoresis systems, it is characterized in that: described driving wheel is a follower gear, described follower gear engagement one driving gear by micro motor for driving.
8. the hold down gag of a kind of electrophoresis system as claimed in claim 4, it is characterized in that: described driving wheel is a follower gear, described follower gear engagement one driving gear by micro motor for driving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310134081.XA CN103235027B (en) | 2013-04-17 | 2013-04-17 | Electrophoresis system compaction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310134081.XA CN103235027B (en) | 2013-04-17 | 2013-04-17 | Electrophoresis system compaction device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103235027A true CN103235027A (en) | 2013-08-07 |
| CN103235027B CN103235027B (en) | 2015-07-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310134081.XA Active CN103235027B (en) | 2013-04-17 | 2013-04-17 | Electrophoresis system compaction device |
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| CN (1) | CN103235027B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111569655A (en) * | 2020-06-12 | 2020-08-25 | 北京六一生物科技有限公司 | Glue making device for making in-situ vertical gel |
Citations (8)
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|---|---|---|---|---|
| EP1128896A1 (en) * | 1998-09-07 | 2001-09-05 | Gradipore Limited | Cassette for macromolecule purification |
| JP2004125701A (en) * | 2002-10-04 | 2004-04-22 | Olympus Corp | Apparatus and method for free flow electrophoresis |
| CN2824030Y (en) * | 2005-09-29 | 2006-10-04 | 北京百晶生物技术有限公司 | Vertical electrophoresis apparatus of once clamping gel chamber |
| CN200968946Y (en) * | 2006-09-01 | 2007-10-31 | 北京市六一仪器厂 | In-situ gum producing device |
| CN201807311U (en) * | 2010-09-27 | 2011-04-27 | 北京市六一仪器厂 | Vertical multi-board in-situ rubber-manufacturing electrophoresis device |
| US20110174621A1 (en) * | 2010-01-19 | 2011-07-21 | Satoshi Yonehara | Method for Analyzing Sample by Electrophoresis and Use of the Same |
| CN202041503U (en) * | 2011-04-26 | 2011-11-16 | 武汉大学 | Electrophoresis rubber-making device of isoenzyme sepharose gel |
| CN202442993U (en) * | 2012-03-06 | 2012-09-19 | 中南大学 | Vertical electrophoresis tank |
-
2013
- 2013-04-17 CN CN201310134081.XA patent/CN103235027B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1128896A1 (en) * | 1998-09-07 | 2001-09-05 | Gradipore Limited | Cassette for macromolecule purification |
| JP2004125701A (en) * | 2002-10-04 | 2004-04-22 | Olympus Corp | Apparatus and method for free flow electrophoresis |
| CN2824030Y (en) * | 2005-09-29 | 2006-10-04 | 北京百晶生物技术有限公司 | Vertical electrophoresis apparatus of once clamping gel chamber |
| CN200968946Y (en) * | 2006-09-01 | 2007-10-31 | 北京市六一仪器厂 | In-situ gum producing device |
| US20110174621A1 (en) * | 2010-01-19 | 2011-07-21 | Satoshi Yonehara | Method for Analyzing Sample by Electrophoresis and Use of the Same |
| CN201807311U (en) * | 2010-09-27 | 2011-04-27 | 北京市六一仪器厂 | Vertical multi-board in-situ rubber-manufacturing electrophoresis device |
| CN202041503U (en) * | 2011-04-26 | 2011-11-16 | 武汉大学 | Electrophoresis rubber-making device of isoenzyme sepharose gel |
| CN202442993U (en) * | 2012-03-06 | 2012-09-19 | 中南大学 | Vertical electrophoresis tank |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111569655A (en) * | 2020-06-12 | 2020-08-25 | 北京六一生物科技有限公司 | Glue making device for making in-situ vertical gel |
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| Publication number | Publication date |
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| CN103235027B (en) | 2015-07-08 |
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