CN103191193A - Traditional chinese medicine extract and preparation method thereof - Google Patents
Traditional chinese medicine extract and preparation method thereof Download PDFInfo
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- CN103191193A CN103191193A CN2013101187699A CN201310118769A CN103191193A CN 103191193 A CN103191193 A CN 103191193A CN 2013101187699 A CN2013101187699 A CN 2013101187699A CN 201310118769 A CN201310118769 A CN 201310118769A CN 103191193 A CN103191193 A CN 103191193A
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Abstract
The invention relates to a natural pharmaceutical composition, a preparation method thereof and application thereof in preparation of toxicity reducing and efficacy enhancing drugs for cancer chemotherapy. The natural pharmaceutical composition consists of a decoction concentrated extract of andrographis paniculata (Burm.f.) Nees and cinnamomum cassia Presl, andrographolide and cinnamic aldehyde which are in the ratio of (2-8):(1-3):(4-9). The composition has an excellent treatment effect on cancer-chemotherapy-related diarrhea and can simultaneously play a synergic role in cancer chemotherapy.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to a kind of natural drug composition of being made up of Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde, the preparation method of this natural drug composition and this natural drug composition are for the preparation of reducing cancer chemotherapy dependency diarrhoea and treatment of cancer being played purposes in the medicine of potentiation.
Background technology
Malignant tumor is current harm humans existence, one of healthy principal disease, and its treatment means comprises operation, chemotherapy, radiotherapy, Chinese medicine, and the effect of chemotherapeutic treatment tumor is particularly outstanding.Chemotherapeutic no matter singly with or unite with toxicity such as all can cause that the patient suffers from diarrhoea, diarrhoea makes the chemotherapy dependency suffer from diarrhoea again behind the chemotherapy of tumors.Emerging and applying along with chemotherapeutics such as 5-fluorouracil, taxanes, hydroxy camptothecin, irinotecan, xeloda etc. in recent years, the incidence rate of chemotherapy dependency diarrhoea improves year by year, and if do not carry out active treatment, easily cause patient's dehydration, malnutrition, serum electrolyte disorder, acid base imbalance etc., it is unfavorable greatly not only the rehabilitation of body to be brought, also bring certain difficulty to CC, therefore effective treatment of chemotherapy dependency diarrhoea has been become the important component part of tumor patient wholistic therapy.
Chemotherapy dependency diarrhoea is with regard to its clinical manifestation, surely belongs to the Chinese medicine category of " having loose bowels ", and Chinese medicine attracts people's attention for the research of having loose bowels, but at present still unmatchful anticancer disease chemotherapy have the Chinese patent medicine of alleviating diarrhoea and potentiation.Therefore, research and develop a kind of high-efficiency low-toxicity, cheap, the natural Chinese medicine that can be used for alleviating cancer chemotherapy dependency diarrhoea and playing the chemotherapeutic sensitivity effect that is easy to promote becomes clinical problem demanding prompt solution.
Herba Andrographis is herb or the leaf of acanthaceous plant Herba Andrographis (Andrographis paniculata (Burm.f.) Nees), and the nature and flavor bitter cold cures mainly damp-heat dysentery.Cortex Cinnamomi is dried bark and the thick branch skin of Lauraceae aiphyllium plant Cortex Cinnamomi Cinnamomum cassia Presl, cures mainly deficiency and coldness and vomits and diarrhoea.In recent years, Herba Andrographis and Cortex Cinnamomi antitumaous effect are confirmed, especially andrographolide and cinnamic aldehyde.The inventor is through research and the experiment of each a large amount of formula proportion, obtained optimal drug ratio compositions of the present invention at last, it is the compositions of novelty, and proved that it has fabulous curative effect and can play potentiation to cancer chemotherapy simultaneously cancer chemotherapy dependency diarrhoea, has finished the present invention thus.
Summary of the invention
A kind of natural drug composition provided by the invention, by Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde by weight in 2-8: the ratio of 1-3: 4-9 is formed.
Above-mentioned natural drug composition, wherein the usage ratio of Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde is 8: 3: 9.
Wherein, Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide can be by well known to a person skilled in the art the conventional method acquisition of purifying, and adopt these compositions that conventional method obtains or the natural drug of the present invention that adopts the commercial one-tenth of buying to be grouped into all can obtain identical curative effect.
Preferably, Herba Andrographis Cortex Cinnamomi water boiling concentration preparation method of extract is in the above-mentioned natural drug composition:
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got Herba Andrographis, Cortex Cinnamomi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
The preparation method of andrographolide is in the above-mentioned natural drug composition:
It is an amount of to take by weighing Common Andrographis Herd, the enzymolysis pre-treatment, the ethanol hot dipping is filtered, recovery ethanol, get extractum, wash with petroleum ether, remove chlorophyll, water layer is spent the night with chloroform extraction, be divided into water layer, chloroform layer and intermediate layer, with intermediate layer precipitate ethyl alcohol recrystallization, get Ling Jingti and be andrographolide.
The cinnamic aldehyde preparation method is in the above-mentioned natural drug composition:
Cortex Cinnamomi is pulverized, take by weighing the Cortex Cinnamomi powder with 95% ethanol in the apparatus,Soxhlet's heating extraction, filtration, behind the decompression recycling ethanol, carry out steam distillation, in distillate, add NaCl, ether divides 3 extractions, merge ether extraction liquid, add an amount of anhydrous calcium chloride desiccant after dry 30 minutes, remove desiccant, reclaim ether, use distilling under reduced pressure then instead, collect 150-151 ℃ fraction, namely get cinnamic aldehyde.
The present invention also provides the preferred manufacturing procedure of this natural drug composition, comprising:
(1) preparation of Herba Andrographis Cortex Cinnamomi water boiling concentration extract
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got Herba Andrographis, Cortex Cinnamomi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
(2) preparation of andrographolide
It is an amount of to take by weighing Common Andrographis Herd, the enzymolysis pre-treatment, the ethanol hot dipping is filtered, recovery ethanol, get extractum, wash with petroleum ether, remove chlorophyll, water layer is spent the night with chloroform extraction, be divided into water layer, chloroform layer and intermediate layer, with intermediate layer precipitate ethyl alcohol recrystallization, get Ling Jingti and be andrographolide.
(3) cinnamic aldehyde preparation
Cortex Cinnamomi is pulverized, take by weighing the Cortex Cinnamomi powder with 95% ethanol in the apparatus,Soxhlet's heating extraction, filtration, behind the decompression recycling ethanol, carry out steam distillation, in distillate, add NaCl, ether divides 3 extractions, merge ether extraction liquid, add an amount of anhydrous calcium chloride desiccant after dry 30 minutes, remove desiccant, reclaim ether, use distilling under reduced pressure then instead, collect 150-151 ℃ fraction, namely get cinnamic aldehyde.
(4) choose Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde in proportion, evenly mix, namely.
The preparation method of above-mentioned natural drug composition, also comprise: the product that step (4) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
The beneficial effect of natural drug composition of the present invention aspect anti-chemotherapy dependency diarrhoea and inhibition tumor is as follows:
1, natural drug composition of the present invention causes the diarrhea of mouse Study of model to show at irinotecan: the diarrhoea reaction for the irinotecan induced mice has tangible antagonism.
2, proved that this natural drug composition can strengthen chemotherapeutics to the inhibitory action of tumor, adopted mouse tumor model, observed this natural drug composition and cyclophosphamide combined to the inhibitory action of mouse interior tumor.Studies show that: this natural drug composition can obviously increase cyclophosphamide for the inhibitory action of tumor.
3, the inventor makes up Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde originally, and by the consumption proportion between definite these components of a large amount of experiments, make said composition bring into play good synergism, obtain unexpected effect.Pass through our experimentation repeatedly, ratio between each component of natural drug composition of the present invention is at 2-8: 1-3: produced unexpected synergism during 4-9, potentiation is obvious, extraordinary effect is played in side effect, especially the usage ratio of each component be 8: 3: 9 o'clock especially obvious, this is that the inventor pays a large amount of creative works by keeping punching and obtains on the paper basis of delivering before, and those of ordinary skills only can't simply obtain this ratio range and optimum amount ratio by disclosed content.
4, this natural drug composition Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and each component of cinnamic aldehyde all can obtain by conventional means, some of them component for example andrographolide and cinnamic aldehyde also can be buied by commerce, and such compositions itself has and obtains convenient, lower-cost effect.This also is the product that has splendid curative effect and higher industrial practicality concurrently that the inventor obtains by a large amount of creative work sides.
The specific embodiment
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and the beneficial effect in diarrhea and antitumor, used.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Herba Andrographis Cortex Cinnamomi water boiling concentration extract
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got Herba Andrographis, Cortex Cinnamomi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
(2) preparation of andrographolide
It is an amount of to take by weighing Common Andrographis Herd, the enzymolysis pre-treatment, the ethanol hot dipping is filtered, recovery ethanol, get extractum, wash with petroleum ether, remove chlorophyll, water layer is spent the night with chloroform extraction, be divided into water layer, chloroform layer and intermediate layer, with intermediate layer precipitate ethyl alcohol recrystallization, get Ling Jingti and be andrographolide.
(3) cinnamic aldehyde preparation
Cortex Cinnamomi is pulverized, take by weighing the Cortex Cinnamomi powder with 95% ethanol in the apparatus,Soxhlet's heating extraction, filtration, behind the decompression recycling ethanol, carry out steam distillation, in distillate, add NaCl, ether divides 3 extractions, merge ether extraction liquid, add an amount of anhydrous calcium chloride desiccant after dry 30 minutes, remove desiccant, reclaim ether, use distilling under reduced pressure then instead, collect 150-151 ℃ fraction, namely get cinnamic aldehyde.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule preparations of the present invention
Take by weighing Herba Andrographis Cortex Cinnamomi water boiling concentration extract 40mg, andrographolide 15mg and the cinnamic aldehyde 45mg of above-mentioned steps preparation respectively, take by weighing starch 395mg, magnesium stearate 5mg simultaneously, evenly mix, make capsule.
(2) preparation of natural drug composition tablet of the present invention
Take by weighing Herba Andrographis Cortex Cinnamomi water boiling concentration extract 40mg, andrographolide 15mg and the cinnamic aldehyde 45mg of above-mentioned steps preparation respectively, take by weighing starch 295mg, lactose 100mg simultaneously, evenly mix, with wet granulation, drying, mix with the 5mg magnesium stearate behind the granulate, be pressed into tablet.
Drug effect and pharmacology's data:
Compositions is in following test example: the usage ratio of Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde is 8: 3: 9.The inventor to above-mentioned each composition usage ratio at 2-8: 1-3: the compositions that the multiple proportioning combination in the time of between the 4-9 obtains has been carried out and last identical experiment, find that all the natural drug composition in this amount ranges can obtain good synergism, can play good effect and treatment for cancer is had potentiation cancer chemotherapy dependency diarrhoea.Below be the pharmacodynamics data that preferred embodiment obtains:
Test example 1: the pharmacodynamic study of natural drug composition treatment chemotherapy dependency diarrhoea effect
1, test material
(1) Herba Andrographis, Cortex Cinnamomi
(2) mice, body weight 20 ± 2g, male, ad lib drinking-water before the experiment.
2, test method:
Mice is divided into 5 groups at random, and 5 every group, the A group is model group, and the B group is Herba Andrographis Cortex Cinnamomi water boiling concentration extract 10g.kg
-1(being equivalent to contain the crude drug amount), the C group is andrographolide 10g.kg
-1(being equivalent to contain the crude drug amount), D group cinnamic aldehyde 10g.kg
-1(being equivalent to contain the crude drug amount), the E group is natural drug composition 10g.kg of the present invention
-1(being equivalent to contain the crude drug amount), irinotecan intraperitoneal injection (75mg/kg), continuous 4 days, copies chemotherapy dependency diarrhoea model at every day 1 time.B, C, D, E group were irritated stomach 8 days with corresponding extract continuously, and mice is placed metabolic cage, spread white filter paper at the bottom of the cage with observation stool situation, and observed mice crissum situation and Mus tail fecal pollution situation, stimulated the anus defecation in conjunction with cotton swab, and every day, observed and recorded was 2 times.Diarrhoea degree standard scoring is as follows: 0 minute: stool is normal or do not have; 1 minute: laxativeness, stool is visible slight wet soft; 2 minutes: the wet and not molding of moderate diarrhoea, stool.And there is slight crissum painted; 3 minutes, severe diarrhoea, watery stool is also painted with the severe crissum.
3, experimental result
Compare with model group, the degree of Herba Andrographis Cortex Cinnamomi water boiling concentration extract group chemotherapy dependency diarrhoea is lower than model group, and natural drug composition group of the present invention diarrhoea incidence rate obviously alleviates.The results are shown in Table 1.
Table 1 present composition is to mice chemotherapy dependency diarrhoea incidence rate and scoring influence
Annotate: a is equivalent to contain the crude drug amount
Test example 2: the pharmacodynamic study of natural drug composition antitumor action of the present invention
1, experiment material
(1) Kunming mouse, body weight 20 ± 2g, ad lib drinking-water before the experiment, 24h natural light irradiation.
(2) cyclophosphamide, the permanent auspicious medical Pharmacy stock Co., Ltd in Jiangsu product.
2, test method:
To mice S
180The inhibition test of sarcoma growth
Employing was gone down to posterity 5-7 days, and well-grown milky ascites is diluted to tumor cell suspension with an amount of physiological saline solution, and cell number is 10
7/ mL, 5 every group, the right axillary fossa subcutaneous vaccination of every Mus 0.2mL (contains oncocyte 2 * 10
6Individual).Inoculation random packet next day, experimental group natural drug composition of the present invention is divided into (200,100mg/mL) two dosage groups, every Mus is irritated stomach 0.5ml, gives cyclophosphamide 10gkg simultaneously
-1D
-1Negative control group gives 0.5mL distilled water; The positive drug group gives cyclophosphamide 10gkg
-1D
-1, successive administration 10 days.The conventional raising, drinking-water, food is not limit.Drug withdrawal next day, mice all takes off cervical vertebra puts to death, and strips subcutaneous solid tumor tumor piece, weighs, and calculates tumor control rate (%) by following formula:
Tumor control rate=(the average tumor of the matched group average tumor of heavy (C)-experimental group heavy (T))/average tumor of matched group heavy (C)
3, result of the test
Natural drug composition of the present invention is low, high dose group all can strengthen the cyclophosphamide agent with to S
180The effect of inhibition degree, especially the strongest with the high dose group effect.(as table 2)
Table 2 natural drug composition of the present invention is to S
180The tumor inhibition effect of mice
Claims (5)
1. natural drug composition that reduces cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation, it is characterized in that said composition by Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde by weight in 2-8: the ratio of 1-3: 4-9 is formed
Wherein Herba Andrographis Cortex Cinnamomi water boiling concentration preparation method of extract is:
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got Herba Andrographis, Cortex Cinnamomi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, is Herba Andrographis Cortex Cinnamomi water boiling concentration extract;
Wherein the preparation method of andrographolide is:
It is an amount of to take by weighing Common Andrographis Herd, the enzymolysis pre-treatment, the ethanol hot dipping is filtered, recovery ethanol, get extractum, wash with petroleum ether, remove chlorophyll, water layer is spent the night with chloroform extraction, be divided into water layer, chloroform layer and intermediate layer, with intermediate layer precipitate ethyl alcohol recrystallization, get Ling Jingti and be andrographolide;
Wherein the preparation method of cinnamic aldehyde is:
Cortex Cinnamomi is pulverized, take by weighing the Cortex Cinnamomi powder with 95% ethanol in the apparatus,Soxhlet's heating extraction, filtration, behind the decompression recycling ethanol, carry out steam distillation, in distillate, add NaCl, ether divides 3 extractions, merge ether extraction liquid, add an amount of anhydrous calcium chloride desiccant after dry 30 minutes, remove desiccant, reclaim ether, use distilling under reduced pressure then instead, collect 150-151 ℃ fraction, namely get cinnamic aldehyde.
2. natural drug composition as claimed in claim 1, wherein the usage ratio of Herba Andrographis Cortex Cinnamomi water boiling concentration extract, andrographolide and cinnamic aldehyde is 8: 3: 9.
3. as the preparation method of the natural drug composition of claim 1 or 2, it is characterized in that this method comprises:
(1) preparation of Herba Andrographis Cortex Cinnamomi water boiling concentration extract
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got Herba Andrographis, Cortex Cinnamomi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, is Herba Andrographis Cortex Cinnamomi water boiling concentration extract;
(2) preparation of andrographolide
It is an amount of to take by weighing Common Andrographis Herd, the enzymolysis pre-treatment, the ethanol hot dipping is filtered, recovery ethanol, get extractum, wash with petroleum ether, remove chlorophyll, water layer is spent the night with chloroform extraction, be divided into water layer, chloroform layer and intermediate layer, with intermediate layer precipitate ethyl alcohol recrystallization, get Ling Jingti and be andrographolide;
(3) preparation of cinnamic aldehyde
Cortex Cinnamomi is pulverized, take by weighing the Cortex Cinnamomi powder with 95% ethanol in the apparatus,Soxhlet's heating extraction, filtration, behind the decompression recycling ethanol, carry out steam distillation, in distillate, add NaCl, ether divides 3 extractions, merge ether extraction liquid, add an amount of anhydrous calcium chloride desiccant after dry 30 minutes, remove desiccant, reclaim ether, use distilling under reduced pressure then instead, collect 150-151 ℃ fraction, namely get cinnamic aldehyde;
(4) choose Herba Andrographis Cortex Cinnamomi water boiling concentration extract in proportion, andrographolide evenly mixes with cinnamic aldehyde, namely.
4. the preparation method of natural drug composition as claimed in claim 3, also comprise: the product that step (4) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
5. as the purposes of each described natural drug composition of claim 1-2 in preparing the medicine that reduces the reaction of cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation.
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Cited By (9)
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| CN103330745A (en) * | 2013-07-19 | 2013-10-02 | 石强 | Natural pharmaceutical composition |
| CN103340926A (en) * | 2013-07-19 | 2013-10-09 | 石强 | Traditional chinese medicine composition and preparation method thereof |
| CN103349702A (en) * | 2013-07-20 | 2013-10-16 | 石强 | Natural medicine composition and preparation method and purposes thereof |
| CN103356743A (en) * | 2013-07-20 | 2013-10-23 | 石强 | Natural medicinal composition, its preparation method and application |
| CN103356831A (en) * | 2013-07-13 | 2013-10-23 | 石强 | Natural pharmaceutical composition and preparation method thereof |
| CN103385922A (en) * | 2013-07-20 | 2013-11-13 | 石强 | Natural pharmaceutical composition and preparation method |
| CN103655775A (en) * | 2013-12-10 | 2014-03-26 | 张宗升 | Natural pharmaceutical composition, and preparation method and application thereof |
| CN106265704A (en) * | 2016-07-26 | 2017-01-04 | 河南大学 | The Traditional Chinese Herb combination of a kind of target tumor hypoxia microenvironment application in oncotherapy |
| CN110218014A (en) * | 2019-06-20 | 2019-09-10 | 福建农林大学 | A kind of natural bacteriostatic method for cement composite material plant fiber |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356831A (en) * | 2013-07-13 | 2013-10-23 | 石强 | Natural pharmaceutical composition and preparation method thereof |
| CN103330745A (en) * | 2013-07-19 | 2013-10-02 | 石强 | Natural pharmaceutical composition |
| CN103340926A (en) * | 2013-07-19 | 2013-10-09 | 石强 | Traditional chinese medicine composition and preparation method thereof |
| CN103349702A (en) * | 2013-07-20 | 2013-10-16 | 石强 | Natural medicine composition and preparation method and purposes thereof |
| CN103356743A (en) * | 2013-07-20 | 2013-10-23 | 石强 | Natural medicinal composition, its preparation method and application |
| CN103385922A (en) * | 2013-07-20 | 2013-11-13 | 石强 | Natural pharmaceutical composition and preparation method |
| CN103655775A (en) * | 2013-12-10 | 2014-03-26 | 张宗升 | Natural pharmaceutical composition, and preparation method and application thereof |
| CN106265704A (en) * | 2016-07-26 | 2017-01-04 | 河南大学 | The Traditional Chinese Herb combination of a kind of target tumor hypoxia microenvironment application in oncotherapy |
| CN110218014A (en) * | 2019-06-20 | 2019-09-10 | 福建农林大学 | A kind of natural bacteriostatic method for cement composite material plant fiber |
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Application publication date: 20130710 |