CN103169921A - Production method of zedoary turmeric oil microcapsule - Google Patents

Production method of zedoary turmeric oil microcapsule Download PDF

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CN103169921A
CN103169921A CN 201310091925 CN201310091925A CN103169921A CN 103169921 A CN103169921 A CN 103169921A CN 201310091925 CN201310091925 CN 201310091925 CN 201310091925 A CN201310091925 A CN 201310091925A CN 103169921 A CN103169921 A CN 103169921A
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microcapsule
sodium
turmeric oil
homogenized
maltodextrin
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CN 201310091925
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Chinese (zh)
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CN103169921B (en )
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简晓红
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武汉蜀泰科技有限公司
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Abstract

The invention relates to a production method of a zedoary turmeric oil microcapsule. The produced zedoary turmeric oil microcapsule comprises the following main components: 35% to 40% of starch sodium octenylsuccinate, 5% to 30% of zedoary turmeric oil, 10% to 20% of mannitol, 5% to 15% of glucose, 15% to 35% of maltodextrin, 0.5% to 1.5% of sodium tripolyphosphate, 1% to 2% of sodium ascorbate, 0.04% to 0.08% of vitamin E, 0.1% to 0.15% of magnesium ascorbyl palmitate and 0.4% to 0.8% of tricalcium phosphate. The production method has the advantages that all raw materials for preparing the zedoary turmeric oil microcapsule conform to the application range of GB2760, i.e., the raw materials are safe and reliable and can be obtained widely; the microcapsule embedding rate reaches more than 99.5%, so that the microcapsule can be directly taken orally and can also be served as the raw material for preparing capsules, suppositories and gels; and the oxidation stability of the microcapsule product is superior to that of the same-type product in the market, i.e., the microcapsule product can be stored for two years at the temperature of 37+/-2 DEG C. Therefore, the production technology can be used for producing the microcapsule which is high in medicinal value, simple to store, convenient and safe to use and low in cost.

Description

一种莪术油微胶囊的生产方法 One kind of Curcuma oil producing microcapsules

技术领域 FIELD

[0001] 本发明涉及一种莪术油微胶囊的生产方法,具体的说是采用多种化学物质为原料包埋莪术油,且其经乳化均质后喷雾干燥得到的一种莪术油微胶囊粉末。 [0001] The present invention relates to a method of producing microcapsules Curcuma oil, specifically Curcuma oil is to use a variety of chemical substances microcapsule powder embedding Curcuma oil as a raw material, and which, after spray drying homomixer .

背景技术 Background technique

[0002] 莪术油具有活血化瘀、行气破滞、消积止痛的功效,主要有抗肿瘤、抗炎、抗病毒、抗炎的药理作用。 [0002] Curcuma oil has a blood circulation, qi stagnation broken, Xiaojizhitong effect, mainly, anti-inflammatory, anti-viral, anti-tumor anti-inflammatory pharmacological effects. 但是由于莪术油本身具有特有的气味,病人在使用中不愿接受,且其作为植物提取油脂,稳定性不好,容易被氧化,氧化后其药效被降低。 However, since the Curcuma oil itself has a peculiar smell, patients are reluctant to accept, in use, and a plant extract as oil, good stability, is easily oxidized, its efficacy is reduced after oxidation. 目前尚有的莪术油微胶囊的生产方法有以明胶、β-环糊精为包埋原料的,包埋率不高,且保质期无法达到2年。 Current production methods are still the Curcuma oil microcapsules are gelatin, β- cyclodextrin as raw material embedding, embedding rate is not high, and the shelf life of 2 years can not be achieved.

发明内容 SUMMARY

[0003] 本发明的目的在于提供较高稳定性且气味较温、药用价值高、使用方便安全且成本低的莪术油微胶囊。 [0003] The object of the present invention to provide a relatively high temperature stability and odor, high medicinal value, safe and easy to use and low cost of Curcuma oil microcapsules.

[0004] 本发明提供的一种莪术油微胶囊的生产方法,生产实施的过程如下: [0004] Curcuma oil production method of the present invention provides a microcapsule, the production process of embodiment is as follows:

(1)准备原料,原料的名称及其质量百分数分别如下:辛烯基琥珀酸淀粉钠为35 -40%、莪术油为5 — 30%、甘露醇为10 — 20%、葡萄糖为5% — 15%、麦芽糊精为15 —35%、三聚磷酸钠为0.5 — 1.5%、抗坏血酸钠为I 一2%、维生素E为0.04 — 0.08%、抗坏血酸棕榈酸酯为0.1 — 0.15%、磷酸三钙为0.4 — 0.8% ; (1) preparation of raw materials, feedstock quality name and percentages are as follows: sodium octenyl succinate starch 35-40% Curcuma oil 5 - 30% Mannitol 10 - 20%, 5% glucose - 15%, maltodextrin 15-35%, sodium tripolyphosphate 0.5 - 1.5% sodium ascorbate was a 2% I, vitamin E is 0.04 - 0.08%, ascorbyl palmitate 0.1 - 0.15%, tricalcium phosphate calcium 0.4 - 0.8%;

(2)将上述的莪术油加热至50 — 60°C,维生素Ε、抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B; (2) The above-described Curcuma oil was heated to 50 - 60 ° C, vitamin Epsilon, ascorbyl palmitate uniformly dissolved therein with stirring, to obtain a mixture B backup;

(3)将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、抗坏血酸钠按比例称量后,溶于一定量水中,得到溶液A ; (3) The sodium octenyl succinate starch, mannitol, maltodextrin, dextrose, sodium tripolyphosphate, according to the ratio of sodium ascorbate were weighed, dissolved in a volume of water to obtain a solution A;

(4)将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10—45MPa,均质三次,使乳滴直径小于0.5 μ m ; (4) A solution B and the mixture was emulsified shear for 30 minutes using a high pressure homogenizer homogenization, homogenization pressure of 10-45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5 μ m;

(5)将均质后乳液进行喷雾干燥,在流化床上均匀加入磷酸三钙作为抗结剂,即得成 (5) After the homogenized emulsion was spray-dried, uniformly added in a fluid bed tricalcium phosphate as an anti-caking agent, to obtain

品O O products

[0005] 本发明一种莪术油微胶囊的生产方法,其优点在于:制备此莪术油微胶囊的全部原料均符合GB2760的应用范围,安全可靠,来源广泛,同时微胶囊包埋率达到99.5%以上,该微胶囊粉末可直接口服,可作为制备胶囊、栓剂、凝胶剂的原料,该微胶囊产品氧化稳定性优于市场同类产品,在温度37±2°C条件下保存两年,此种生产技术为一种药用价值高、保存简单、使用方便安全且成本低的微胶囊技术。 [0005] The present invention provides a Curcuma producing oil microcapsules, which is advantageous in that: preparing such Curcuma oil microcapsule total feed comply application GB2760, safe and reliable, widely available, while the microencapsulation rate reached 99.5% above, the microcapsules may be administered orally as powder, as starting materials can be prepared capsules, suppositories, gels, and the microcapsule product oxidative stability than similar products in the market, kept for two years at a temperature of 37 ± 2 ° C conditions, this seed production technology is high a medicinal value, save the simple, easy to use safe and low-cost micro-capsule technology.

具体实施方式 Detailed ways

[0006] 本发明提供的一种莪术油微胶囊的生产方法,生产实施的过程如下: [0006] Curcuma oil production method of the present invention provides a microcapsule, the production process of embodiment is as follows:

(1)准备原料,原料的名称及其质量百分数分别如下:辛烯基琥珀酸淀粉钠为35 -40%、莪术油为5 — 30%、甘露醇为10 — 20%、葡萄糖为5 — 15%、麦芽糊精为15 — 35%、三聚磷酸钠为0.5 — 1.5%、抗坏血酸钠为I 一2%、维生素E为0.04 — 0.08%、抗坏血酸棕榈酸酯为0.1 — 0.15%、磷酸三钙为0.4 — 0.8% ; (1) preparation of raw materials, feedstock quality name and percentages are as follows: sodium octenyl succinate starch 35-40% Curcuma oil 5 - 30% Mannitol 10 - 20%, glucose 5--15 % maltodextrin 15 - 35% sodium tripolyphosphate 0.5 - 1.5% sodium ascorbate was a 2% I, vitamin E is 0.04 - 0.08%, ascorbyl palmitate 0.1 - 0.15%, tricalcium phosphate 0.4 - 0.8%;

(2)将上述的莪术油加热至50 — 60°C,维生素E、抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B; (2) The above-described Curcuma oil was heated to 50 - 60 ° C, vitamin E, ascorbyl palmitate uniformly dissolved therein with stirring, to obtain a mixture B backup;

(3)将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、抗坏血酸钠按比例称量后,溶于一定量水中,得到溶液A ; (3) The sodium octenyl succinate starch, mannitol, maltodextrin, dextrose, sodium tripolyphosphate, according to the ratio of sodium ascorbate were weighed, dissolved in a volume of water to obtain a solution A;

(4)将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10—45MPa,均质三次,使乳滴直径小于0.5 μ m ; (4) A solution B and the mixture was emulsified shear for 30 minutes using a high pressure homogenizer homogenization, homogenization pressure of 10-45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5 μ m;

(5)将均质后乳液进行喷雾干燥,在流化床上均匀加入磷酸三钙作为抗结剂,即得成 (5) After the homogenized emulsion was spray-dried, uniformly added in a fluid bed tricalcium phosphate as an anti-caking agent, to obtain

品O O products

[0007] 实施例一 [0007] Example a

按比例称取辛烯基琥珀酸淀粉钠200.00g、莪术油150.00g、甘露醇50.00g、葡萄糖25.00g、麦芽糊精64.80g、三聚磷酸钠2.50g、抗坏血酸钠5.00g、维生素E 0.20g、抗坏血酸棕榈酸酯0.50g、磷酸三钙2.0Og;将莪术油加热至50 — 60°C,维生素E和抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B;将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、抗坏血酸钠按比例称量混匀后,溶于一定量水中,得到溶液A ;将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10 — 45MPa,均质三次,使乳滴直径小于0.5μηι ;将均质后乳液进行`喷雾干燥,在流化床上均匀加入磷酸三钙作为抗结剂,即得成品。 Weigh scale starch sodium octenyl succinate 200.00g, Curcuma oil 150.00g, mannitol 50.00g, glucose 25.00g, maltodextrin 64.80g, 2.50 g sodium tripolyphosphate, sodium ascorbate 5.00g, vitamin E 0.20g , ascorbyl palmitate 0.50g, tricalcium phosphate 2.0Og; the Curcuma oil was heated to 50 - 60 ° C, vitamin E and ascorbyl palmitate uniformly dissolved therein with stirring, to obtain a mixture standby B; the starch octenyl succinate sodium, mannitol, maltodextrin, dextrose, sodium tripolyphosphate, sodium ascorbate after mixing proportionally weighed, dissolved in a volume of water to obtain a solution A; solution A and the mixture B emulsified shear for 30 minutes, with high-pressure homogenizer homogenized, homogenization pressure of 10 - 45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5μηι; `the homogenized emulsion was spray-dried, uniformly added in a fluid bed tricalcium phosphate as an anti- coalescent, that is finished.

[0008] 实施例二 [0008] Second Embodiment

按比例称取辛烯基琥珀酸淀粉钠175.00g、莪术油25.00g、甘露醇100.00g、葡萄糖75.00g、麦芽糊精102.35g、三聚磷酸钠7.50g、抗坏血酸钠10.00g、维生素E 0.40g、抗坏血酸棕榈酸酯0.75g、磷酸三钙4.0Og;将莪术油加热至50 — 60°C、维生素E和抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B ;将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、VC钠按比例称量混匀后,溶于一定量水中,得到溶液A ;将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10 — 45MPa,均质三次,使乳滴直径小于0.5 μ m ;将均质后乳液进行喷雾干燥,在流化床上均匀加入磷酸三钙作为抗结剂,即得成品。 Weigh scale starch sodium octenyl succinate 175.00g, Curcuma oil 25.00g, mannitol 100.00g, glucose 75.00g, maltodextrin 102.35g, sodium tripolyphosphate 7.50g, 10.00 g of sodium ascorbate, vitamin E 0.40g , ascorbyl palmitate 0.75g, tricalcium phosphate 4.0Og; the Curcuma oil was heated to 50 - 60 ° C, vitamin E and ascorbyl palmitate uniformly dissolved therein with stirring, to obtain a mixture standby B; the starch octenyl succinate sodium, mannitol, maltodextrin, dextrose, sodium tripolyphosphate, sodium VC after mixing proportionally weighed, dissolved in a volume of water to obtain a solution A; solution A and the mixture B emulsified shear for 30 minutes, with high-pressure homogenizer homogenized, homogenization pressure of 10 - 45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5 μ m; the homogenized emulsion was spray-dried, uniformly added in a fluid bed tricalcium phosphate as an anti- coalescent, that is finished.

[0009] 实施例三 [0009] Example three

按比例称取辛烯基琥珀酸淀粉钠190.00g、莪术油80.00g、甘露醇70.00、葡萄糖45.00g、麦芽糊精98.60g、三聚磷酸钠5.00g、抗坏血酸钠7.50g、维生素E 0.30g、抗坏血酸棕榈酸酯0.60g、磷酸三钙3.0Og;将莪术油加热至50 — 60°C,维生素E和抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B;将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、抗坏血酸钠按比例称量混匀后,溶于一定量水中,得到溶液A ;将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10 — 45MPa,均质三次,使乳滴直径小于0.5μηι;将均质后乳液进行喷雾干燥,在流化床上均匀加入磷酸三钙作为抗结剂,即得成品。 Weigh scale starch sodium octenyl succinate 190.00g, 80.00 g of Curcuma oil, 70.00 mannitol, 45.00g glucose, maltodextrin 98.60g, 5.00 g sodium tripolyphosphate, 7.50 g sodium ascorbate, vitamin E 0.30g, 0.60 g of ascorbyl palmitate, tricalcium phosphate 3.0Og; the Curcuma oil was heated to 50 - 60 ° C, vitamin E and ascorbyl palmitate uniformly dissolved therein with stirring, to obtain a mixture standby B; the starch sodium octenyl succinate , mannitol, maltodextrin, dextrose, sodium tripolyphosphate, sodium ascorbate after mixing proportionally weighed, dissolved in a volume of water to obtain a solution A; solution A and the mixture B emulsified shear for 30 minutes, with high pressure homogenizer homogenized, homogenization pressure of 10 - 45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5μηι; after the homogenized emulsion was spray-dried, uniformly added in a fluid bed tricalcium phosphate as an anti-caking agent , ie finished.

Claims (1)

1.一种莪术油微胶囊的生产方法,其特征在于:其制备过程如下: (1)准备原料,原料的名称及其质量百分数分别如下:辛烯基琥珀酸淀粉钠为35 -40%、莪术油为5 — 30%、甘露醇为10 — 20%、葡萄糖为5% — 15%、麦芽糊精为15 —35%、三聚磷酸钠为0.5 — 1.5%、抗坏血酸钠为1 一2%、维生素E为0.04 — 0.08%、抗坏血酸棕榈酸酯为0.1 — 0.15%、磷酸三钙为0.4 — 0.8% ; (2)将上述的莪术油加热至50 — 60°C,维生素E、抗坏血酸棕榈酸酯溶解在其中搅拌均匀,备用得到混合物B; (3)将辛烯基琥珀酸淀粉钠、甘露醇、麦芽糊精、葡萄糖、三聚磷酸钠、抗坏血酸钠按比例称量后,溶于一定量水中,得到溶液A ; (4)将溶液A和混合物B乳化剪切30分钟后,用高压均质机进行均质,均质压力为10—45MPa,均质三次,使乳滴直径小于0.5 μ m ; (5)将均质后乳液进行喷雾干燥,在流化床上均匀加入磷酸 1. A method of producing microcapsules Curcuma oil, characterized in that: the preparation process is as follows: (1) preparation of raw materials, feedstock quality name and percentages are as follows: sodium starch octenyl succinate is 35-40%, Curcuma oil 5 - 30% mannitol 10 - 20%, dextrose 5% - 15%, maltodextrin 15-35%, sodium tripolyphosphate 0.5 - 1.5%, 1 sodium ascorbate to a 2% vitamin E is 0.04 - 0.08%, ascorbyl palmitate 0.1 - 0.15%, tricalcium phosphate 0.4 - 0.8%; (2) the above-described Curcuma oil was heated to 50 - 60 ° C, vitamin E, ascorbyl palmitate stir ester was dissolved therein, to give a mixture standby B; (3) the sodium octenyl succinate starch, mannitol, maltodextrin, dextrose, sodium tripolyphosphate, sodium ascorbate weighing scale, a certain amount of dissolved water to obtain a solution A; (. 4) the mixture solution A and B after 30 minutes of shear emulsified, homogenized with a high-pressure homogenizer, homogenization pressure of 10-45MPa, homogenized three times the diameter of the emulsion droplets is less than 0.5 μ m; (5) after the homogenized emulsion was spray-dried in a fluid bed uniformly phosphoric acid 三钙作为抗结剂,即得成品。 As the anti-caking agent tricalcium derived products.
CN 201310091925 2013-03-21 2013-03-21 One kind of Curcuma oil producing microcapsules CN103169921B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520262A (en) * 2013-10-18 2014-01-22 大连伍陆柒捌生物工程有限公司 Lipid soluble gynecological gel

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679712A (en) * 2005-01-18 2005-10-12 张红军 Non-injection aromatic turmeric oil preparation and preparing method thereof
CN101019838A (en) * 2007-02-12 2007-08-22 清华大学 Linseed oil microcapsule powder and its prepn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679712A (en) * 2005-01-18 2005-10-12 张红军 Non-injection aromatic turmeric oil preparation and preparing method thereof
CN101019838A (en) * 2007-02-12 2007-08-22 清华大学 Linseed oil microcapsule powder and its prepn

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520262A (en) * 2013-10-18 2014-01-22 大连伍陆柒捌生物工程有限公司 Lipid soluble gynecological gel

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