CN103157126B - 创可胶及其制备方法 - Google Patents
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Abstract
本发明涉及一种创可胶及其制备方法，特别是涉及一种用于皮肤创伤的创可胶及其制备方法，主要属于外科医疗器械技术和敷料材料领域。其特征在于：主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶、壳聚糖衍生物；溶剂为乙醇；所述聚乙烯醇缩丁醛，包括SD-1等；所述松香为脂松香等的一种或2种(含)以上混合物；所述蜂胶为天然蜂胶、药用蜂胶的一种或2种(含)以上混合物；所述壳聚糖衍生物为壳聚糖以及衍生物的1种或2种(含)以上混合物；其制备方法：(1)称取聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖，形成混合物A；(2)注入乙醇，搅拌并溶解，形成敷料B；(3)将敷料B灌装，包装即得创可胶。
Description
技术领域
本发明涉及一种创可胶及其制备方法，特别是涉及一种用于皮肤创伤的创可胶及其制备方法，主要属于外科医疗器械技术和敷料材料领域。
背景技术
聚乙烯醇缩丁醛是聚乙烯醇和丁醛的聚合物，白色粉末，相对密度1.08～1.10。可溶于甲醇、乙醇、酮类、卤代烷、芳烃类溶剂，由于其柔顺性、粘附性和高生物安全度，作为粘附剂、改型增塑剂被广泛的应用于医疗、工业等各个领域，是非常安全的附膜基质材料。
松香为微黄至黄红色的透明固体，软化点70～90℃，比重1.070～1.085，在热熔、压敏和溶剂型胶黏剂中常用作增黏树脂，增加初黏性，提高粘结强度。其是一种弱酸性物质，在医疗领域，具有祛风燥湿，生肌止痛，常用于痈疖疮疡，外伤出血，烧烫伤等。
蜂胶是蜜蜂从植物芽孢或树干上采集的树脂，混入其上腭腺、蜡腺的分泌物加工而成的一种具有芳香气味的胶状固体物。呈棕黄色或黄褐色，遇热变软具粘性，是安全的胶粘剂。在医疗领域，应用于体虚早衰、高脂血症、消渴以及皮肤皲裂、烧烫伤。
壳聚糖及其衍生物具有镇痛止血、促进创伤愈合和抑制疤痕增生等功效，在医药领域中，已经有广泛的研究和应用。
发明内容
本发明的目的是提供一种具有防水防尘、促进创伤愈合和减少疤痕产生的创可胶及其制备方法，用以解决市场上现有各种敷料的不足。
一种创可胶及其制备方法，其特征在于：主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶、壳聚糖衍生物，溶剂为乙醇；所述聚乙烯醇缩丁醛，包括SD-1、SD-2、SD-3、SD-4、SD-5、SD-6、SD-7；所述松香为脂松香、木松香、浮油松香的一种或2种(含)以上混合物；所述蜂胶为天然蜂胶、药用蜂胶的一种或2种(含)以上混合物；所述壳聚糖衍生物为壳聚糖以及其酰基基化物、羧基化物、烷基化物、酯化物的1种或2种(含)以上混合物；其制备方法：(1)、称取适量聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖，充分搅拌混合，形成混合物A；(2)、向混合物A注入乙醇，边注入边搅拌，使其充分溶解，形成胶体敷料B；(3)、将制得到的胶体敷料B灌装，包装即得创可胶。
本发明的创可胶中的缩丁醛为基质材料，松香为创伤恢复提供一个微环境，蜂胶帮助粘合在皮肤表面，壳聚糖及其衍生物促进创伤愈合和减少疤痕组织形成，对各种手术创口、烧烫伤和溃疡等各种创伤具有良好的保护和修复作用，具有重要的开发价值。
具体实施方式
下面通过实施例对本发明做进一步详细说明，这些实施例仅用来说明本发明，并不限制本发明的范围。
实施例1
(1)一种创可胶，主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶、壳聚糖衍生物；溶剂为乙醇；制备原料按以下组成：聚乙烯醇缩丁醛50克、松香25克、蜂胶15克、羧基壳聚糖10克；
(2)创可胶制备方法，包括以下步骤：
1)、将聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖，充分搅拌混合，形成混合物A；
2)、向混合物A注入乙醇，边注入边搅拌，使其充分溶解，形成胶体敷料B；
3)、将制得到的胶体敷料B灌装，包装即得创可胶。
实施例2
(1)一种创可胶，主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶、壳聚糖衍生物；溶剂为乙醇；制备原料按以下组成：聚乙烯醇缩丁醛40克、松香30克、蜂胶15克、羧基壳聚糖15克；
(2)创可胶制备方法，包括以下步骤：
1)、将聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖，充分搅拌混合，形成混合物A；
2)、向混合物A注入乙醇，边注入边搅拌，使其充分溶解，形成胶体敷料B；
3)、将制得到的胶体敷料B灌装，包装即得创可胶。
实施例3
(1)一种创可胶，主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶、壳聚糖衍生物；溶剂为乙醇；制备原料按以下组成：聚乙烯醇缩丁醛30克、松香35克、蜂胶25克、羧基壳聚糖10克；
(2)创可胶制备方法，包括以下步骤：
1)、将聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖，充分搅拌混合，形成混合物A；
2)、向混合物A注入乙醇，边注入边搅拌，使其充分溶解，形成胶体敷料B；
3)、将制得到的胶体敷料B灌装，包装即得创可胶。
Claims (8)
1.一种创可胶，其特征在于：主要由溶质和溶剂所组成的胶体，溶质为基质聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖衍生物；溶剂为乙醇。
2.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的溶剂挥发后，形成防水敷料涂层薄膜。
3.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的基质聚乙烯醇缩丁醛包括SD-1、SD-2、SD-3、SD-4、SD-5、SD-6、SD-7。
4.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的松香为脂松香、木松香、浮油松香的一种或2种以上混合物。
5.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的蜂胶为天然蜂胶、药用蜂胶的一种或2种混合物。
6.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的壳聚糖衍生物为壳聚糖其酰基化物、羧基化物、烷基化物、酯化物的1种或2种以上混合物。
7.根据权利要求1所述的一种创可胶，其特征在于：所述的创可胶的溶剂为乙醇，其浓度为50％～100％。
8.根据权利要求1所述的一种创可胶的制备方法，其特点在于：包括以下步骤：
(1)、称取适量聚乙烯醇缩丁醛、松香、蜂胶和壳聚糖衍生物，充分搅拌混合，形成混合物A；
(2)、向混合物A注入乙醇，边注入边搅拌，使其充分溶解，形成胶体敷料B；
(3)、将制得到的胶体敷料B灌装，包装即得创可胶。
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| CN105688270A (zh) * | 2016-01-07 | 2016-06-22 | 王清清 | 一种液体创可贴及其制备方法 |
| CN106039293A (zh) * | 2016-07-28 | 2016-10-26 | 广州赛莱拉干细胞科技股份有限公司 | 一种修复皮肤溃疡的组合物及其制备方法 |
| CN107320767A (zh) * | 2017-06-05 | 2017-11-07 | 浙江工业大学 | 一种含n‑糖基化壳聚糖的快速成膜流体敷料及其制备与应用 |
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| CN101596310A (zh) * | 2008-06-02 | 2009-12-09 | 彭强 | 一种用于创面修复的人工基底膜乳膏 |
| CN101920042A (zh) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | 一种液体创口贴及制备方法 |
| CN102198159A (zh) * | 2011-06-08 | 2011-09-28 | 李会珍 | 一种治疗烧伤疮疡的药物及采用该药物制成的创面贴 |
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| CN101927028A (zh) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | 壳聚糖/缩醛化聚乙烯醇医用敷料的制备方法 |
| CN102274542A (zh) * | 2011-08-30 | 2011-12-14 | 夏敬民 | 一种成膜型防水透气护创液及其制备方法 |
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| CN101920042A (zh) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | 一种液体创口贴及制备方法 |
| CN102198159A (zh) * | 2011-06-08 | 2011-09-28 | 李会珍 | 一种治疗烧伤疮疡的药物及采用该药物制成的创面贴 |
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