CN103126702A

CN103126702A - External marking point for multimodal medical image fusion

Info

Publication number: CN103126702A
Application number: CN201110397187XA
Authority: CN
Inventors: 陈兆秋; 赵风岭; 李万湖; 尚东平; 尹勇; 马莉; 付正
Original assignee: 陈兆秋
Priority date: 2011-12-05
Filing date: 2011-12-05
Publication date: 2013-06-05
Anticipated expiration: 2031-12-05
Also published as: CN103126702B

Abstract

The invention relates to an external marking point which can supply alignment and fusion of a multimodal medical image, namely, computed tomography (CT), digital subtraction angiography (DSA), magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission computed tomography (SPECT). The external marking point for the multimodal medical image fusion comprises a hollow ball which is formed by fixed connection of a ball body (1) and a ball cover (2) through a connecting port (3), namely the ball body (1) is provided with a hollow cavity with filling imaging liquid. Due to the fact that the imaging liquid can be imagined into a round-point shape at any angle in the ball body, the alignment can be found easily, the precision of registration and the fusion is improved, and the marking point is not only used for image fusion, but also is used for surgery, puncture navigation, tumor guiding radiotherapy and the like.

Description

Multi-modality medical image fusant OM outer marker point

Technical field:

The invention belongs to the medical aid technical field, when specifically a kind of multi-modality medical image (CT, DSA, MRI, PET, SPECT etc.) registration merges, on the image of seeking at external index point.

Background technology:

Along with developing rapidly of Medical Imaging and computer technology, multiple advanced person's medical imaging devices provides the medical image information of multiple modalities for clinical diagnosis.The medical image of different modalities can show the information of human internal organ and pathological tissues different qualities.The multi-modality medical image fusion is applied to medical image with image fusion technology exactly, to deriving from the medical image of different medical imaging devices, through fusion treatment, obtain the new medical image that includes more information, thereby provide more human dissection and the physiological and pathological information of horn of plenty for clinical diagnosis.The key of image co-registration is image registration.The image registration methods that adopt based on Image Control Point more.Control point and external control point in the split of control point.In body, the control point is anatomic landmark point in some bodies, seeks difficult, bothersome, and requiring has certain experience, with some subjectivitys, is difficult for grasping.Adopt external control point obviously, accurately, the registration amount of calculation is little, good stability, speed is fast, and precision is high, easily grasps, but external control point is not the imaging point of identical material, need to change in different imaging device inspections, satisfies the requirement of this equipment control point imaging.Control point when medical skill personnel wish a kind of multi-modal external tag point as image co-registration, index point is fixed in the external of inspection treatment patient, the image check of changing different modalities does not need to change index point, and can provide image registration fusant OM outer marker, reduce operation link, improved the image co-registration precision.

The material that is common at present multi-modal video picture only has liquid state.Liquid is deformed, could develop in the tubule of the shaping of must packing into, bead to be line, point-like on image.The possessor utilizes the liquid of energy video picture to invent the external tag of some image co-registration to the greatest extent, determines index point but be position or the angle of utilizing developing line, has signage greatly and the not high shortcoming of precision.

Technology consists of:

The object of the present invention is to provide a kind of simple in structure, small and exquisite, convenient fixing, and can scan on multiple imaging device, and the external tag point of external tag image clearly can be provided.

The present invention realizes like this.This multi-modality medical image fusant OM outer marker point, it is to be fixedly connected with the hollow ball that consists of through connector with spherical cap by spheroid, namely spheroid is with the cavity of fill imaging liquid.The connector of spheroid and spherical cap can be threaded connection; Can be also socket, then through the elastic gum zone circle, they are fixed together; Can also they be bonded together through fluid sealant.

During use, a plurality of signages are disperseed to be fixed in the human body surface scope of target scan, carry out the scanning of multi-modal (CT, DSA, MRI, PET, SPECT) medical image, the scanning position of each mode is consistent, good reproducibility.The scanning bed thickness is less than or equal to the ball internal diameter as far as possible, and the interior imaging liquid of ball is fully developed; Scan mode adopts continuously every continuous sweep, is beneficial to image volume and rebuilds.The multi-modality images data are sent to the image processing workstation, first carry out the single mode volume reconstruction, the method for then controlling one to one fusion according to the external tag space of points is carried out selecting type two mode image co-registration, thereby arrives comprehensive fusion of two modal datas.The layering of this comprehensive fusion image is browsed, and contains much information, and is beneficial to diagnosis and guiding treatment disease.Because any angle imaging of imaging liquid in sacculus is all round point shape, be easy to seek registration, improved registration and fusion accuracy.Index point not only is used for image co-registration, also is used for operation, puncture navigation, and the guided radiation treatment tumor etc.Utilize the control of external tag point to carry out different modalities image co-registration in twos, be conducive to improve the precision of image co-registration, be convenient to diagnose and treat diseases.

Description of drawings

Fig. 1 is structure principle chart of the present invention;

Fig. 2 is folliculus ball spherical shell profile of the present invention;

Fig. 3 is signage profile of the present invention.

Embodiment:

Below in conjunction with accompanying drawing, the present invention is described in detail.

This multi-modality medical image fusant OM outer marker point, it is to be fixedly connected with the hollow ball of formation through connector (3) with spherical cap (2) by spheroid (1), namely spheroid is with the cavity of fill imaging liquid (4).The connector (3) of spheroid (1) and spherical cap (2) can be threaded connection; Can be also socket, then through elastic gum zone circle (5), they are fixed together; Can also they be bonded together through fluid sealant.

Adopting different connected modes between spheroid (1) and spherical cap (2), is mainly to have the restriction of time half-life for radionuclide imaging.For application of radiation radio nuclide imaging developer solution, need the multi-modal imaging liquid of radionuclide necessary now with the current, cause as the folliculus ball of sign and now fill with existing envelope.Add the radiosiotope that has in right amount PET or SPECT video picture in the two aobvious liquid of the transparent CT/MRI of redness, just become multi-modal imaging liquid (4).With little needle tubing, multi-modal imaging liquid (4) is injected in spheroid, the impact of liquid body adhesion, the high ball mouth of liquid meeting, the spherical cap fold is lived spheroid, or in multi-modal imaging liquid with spheroid and spherical cap tweezers fold, the folliculus ball that the ball intracavity is full of imaging liquid (4) is pressed into to have in elastic adhesive tape circle (5) and namely becomes signage.If there is no radionuclide imaging in multi-modal imaging liquid, namely there is no the time restriction of half-life, be normal video picture liquid, available sealant sealing bead replaces the elastic gum zone circle.Because this special signage development index point is obvious, be easy to identification and registration; The development main body is spherical, is all circular in any scanning angle and imaging angle, is easy to find accurately index point, thereby has improved registration and fusion accuracy.Utilize the control of external tag point to carry out different modalities image co-registration in twos, be conducive to improve the precision of image co-registration, be convenient to diagnose and treat diseases.

Take cranium brain MRI, PET image co-registration as example.The radionuclide of PET is mixed being made into multi-modal imaging liquid with the red two aobvious liquid of 3 milliliters of CT/MRI, recommended dose is about 0.01 millicurie/milliliter.Select 5, the sign ball of internal diameter 4mm, the full multi-modal imaging liquid of its perfusion and fold with the shutoff of latex zone circle, are made 5 multi-modal video picture signages.With adhesive plaster, above-mentioned 5 signages are disperseed to be fixed on person under inspection's head.PET checks in advance, the nonseptate MR scanning of rear row 4mm bed thickness.The data of PET and MR are sent to the image processing workstation, carry out respectively volume reconstruction.The rear image of reconstruction carries out the space according to the outer index point of cranium brain and merges one to one, thereby arrives comprehensive image co-registration of cranium brain MRI and PET.

Claims

1. multi-modality medical image fusant OM outer marker point, it is characterized in that: it is fixedly connected with the hollow ball of formation through connector (3) with spherical cap (2) by spheroid (1), namely spheroid (1) is with the cavity of fill imaging liquid (4).

2. multi-modality medical image fusant OM outer marker point according to claim 1, it is characterized in that: spheroid (1) and spherical cap (2) are fixed together by elastic gum zone circle (5).