CN103054998A - Compound coptis chinensis liquid - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine, and discloses a compound coptis chinensis liquid which is prepared by using coptis chinensis, scutellaria baicalensis, golden cypress, jasmine, garden burnet, rheum officinale, astragalus mongholicus and borneol as raw materials and boiling in water and extracting. The compound coptis chinensis liquid has a good effect in treating chronic osteomyelitis and acute soft tissue injury, reduces the production cost, is simple and convenient to use, wide in application range and convenient to store and popularize.

Description

Compound coptis chinensis liquid

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of compound coptis chinensis liquid that is used for the treatment of chronic osteomyelitis and acute soft tissue injury.

Background technology

Chronic osteomyelitis is one of orthopedics department difficult disease, belongs to the category of the traditional Chinese medical science " pyogenic infection of the bone ", has that sickness rate is high, the course of disease is long, and the Chang Fanfu outbreak is difficult for radical cure, easily causes the characteristics such as invalid.The main method of existing integrative therapy chronic osteomyelitis comprises Antibiotic use, operative treatment and by improving systemic conditions to improve the aspects such as resistance of body.Although Antibiotic use plays great role in the treatment chronic osteomyelitis,, life-time service can be because the generation of drug resistance often makes its curative effect reduce.In addition, because the surrounding tissue fibrosis of chronic osteomyelitis focus, the pathological changes such as existence of sequestrum dead space have caused local blood for poor, this not only makes the intralesional antibiotic not reach valid density, also makes the immune system of body and other Disease-resistant factor can not bring into play effective effect.Though the local antibiotic that uses can make the intralesional antibiotic concentration improve several times to tens times, thereby plays effective bacteriostasis, has suppressed simultaneously growth and the filling of granulation tissue, is unfavorable for the reparation of wound.Because the progress of microsurgical technique adopts the method for tissue transplantation to eliminate exposed bone, supply to improve curative effect thereby improve local blood, but the mortality of this type of operation is also higher in recent years.

In addition, external treatment of Chinese medicine is the characteristic of Chinese traditional treatment chronic osteomyelitis, but most cream, pellet, ball, not only manufacture method is complicated for the loose important preparation of class, and used medicine mostly is rare valuable medicinal, is difficult for obtaining.And solid dosage medicine has limited the contact area with focus on the one hand, is unfavorable for bringing into play therapeutical effect, may leave in the part on the other hand foreign body and be unfavorable for treatment.

Summary of the invention

For above-mentioned deficiency, the purpose of this invention is to provide a kind of compound coptis chinensis liquid, selecting Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Radix Sanguisorbae, Radix Et Rhizoma Rhei, the Radix Astragali is raw material, extracts through decocting method to form, and the treatment of chronic osteomyelitis and acute soft tissue injury is had good result.

For achieving the above object, the technical solution adopted in the present invention is:

A kind of compound Rhizoma Coptidis liquid, made by the raw material of following weight (part) proportioning:

Rhizoma Coptidis 80～100, Radix Scutellariae 27～34, Cortex Phellodendri 27～34, Fructus Gardeniae 27～35, Radix Sanguisorbae 27～33, Radix Et Rhizoma Rhei 27～34, the Radix Astragali 27～34, Borneolum Syntheticum 9～12.

Further, described optimum weight (part) proportioning is Rhizoma Coptidis 90, Radix Scutellariae 30, Cortex Phellodendri 30, Fructus Gardeniae 30, Radix Sanguisorbae 30, Radix Et Rhizoma Rhei 30, the Radix Astragali 30, Borneolum Syntheticum 10.

The manufacture method of above-mentioned compound coptis chinensis liquid may further comprise the steps:

(1), get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Radix Sanguisorbae, Radix Et Rhizoma Rhei, the Radix Astragali, 100 ℃ in the water that adds 10 times of amounts extracted 2 hours, leached medicinal liquid for subsequent use, got medicinal residues;

(2), get step (1) medicinal residues, 100 ℃ in the water that adds 8 times of amounts extracted 2 hours, leached medicinal liquid for subsequent use;

(3), combining step (1), (2) medicinal liquid, be concentrated into 80 ℃ of temperature, relative density 1.1～1.3 is cooled to room temperature, adds Borneolum Syntheticum and 2 times of amount ethanol stir, and leaves standstill, and gets supernatant, Recycled ethanol adds purified water to ormal weight.

Further, described ormal weight medicinal liquid is that every 100g Rhizoma Coptidis can prepare 6～7L medicinal liquid ratio.

Beneficial effect of the present invention is: the compound coptis chinensis liquid that adopts this prescription to make, overcome the deficiency of prior art antibiotic, operative therapy, treatment to chronic osteomyelitis and acute soft tissue injury has good result, reduced production cost, use simple, convenient, applied widely, be convenient to store and promote.

The specific embodiment

In order to make technical scheme of the present invention more explicit, be further elaborated below in conjunction with specific embodiment:

A kind of compound Rhizoma Coptidis liquid of the present invention is made by the raw material of following weight (part) proportioning: Rhizoma Coptidis 80～100, Radix Scutellariae 27～34, Cortex Phellodendri 27～34, Fructus Gardeniae 27～35, Radix Sanguisorbae 27～33, Radix Et Rhizoma Rhei 27～34, the Radix Astragali 27～34, Borneolum Syntheticum 9～12, wherein optimum weight (part) proportioning is Rhizoma Coptidis 90, Radix Scutellariae 30, Cortex Phellodendri 30, Fructus Gardeniae 30, Radix Sanguisorbae 30, Radix Et Rhizoma Rhei 30, the Radix Astragali 30, Borneolum Syntheticum 10.

The drug effect overview of above-mentioned prescription main Chinese medicinal materials is as follows:

The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication; Radix Scutellariae dampness expels the heat-evil, and cooling blood for hemostasis has heat clearing away and hemostasis dual function; The Cortex Phellodendri heat clearing away is scorching, brings down a fever except rash; Fructus Gardeniae clearing away heat-fire nature and flavor also belong to bitter cold; But Borneolum Syntheticum is the property hardship heat clearing away granulation promoting that is slightly cold then; Radix Sanguisorbae cooling blood for hemostasis and Rhizoma Coptidis match, and strengthen the power of heat-clearing and toxic substances removing.Each medicine cooperates, and lets out middle Jiao's fire with the monarch of Rhizoma Coptidis, and Radix Scutellariae is let out the fire of the part of the body cavity above the diaphragm housing the heart and lungs, and Cortex Phellodendri diarrhea Jiao's fire be minister, the remove heat by catharsis fire of three warmers of Fructus Gardeniae, and heat conduction is descending, and the sweet cold of Borneolum Syntheticum is detoxified.All medicines gather heat clearing and blood stasis dispersing altogether, logical regulating menstruation network, reducing swelling and alleviating pain, the effect of dehumidifying granulation promoting.In addition, Radix Et Rhizoma Rhei, Radix Scutellariae, Cortex Phellodendri all have antibiotic effect, and the Cortex Phellodendri external also can promote the absorption of subcutaneous extvavasated blood in addition, and Radix Et Rhizoma Rhei contains chrysophanol, can fine and close blood capillary.The heat clearing and blood stasis dispersing medicinal liquid is directly outer to spread on the affected part, can improve histiocytic permeability, is conducive to drug absorption, strengthens its curative effect.

Embodiment 1

Get Rhizoma Coptidis 90g, Radix Scutellariae 30g, Cortex Phellodendri 30g, Fructus Gardeniae 30g, Radix Sanguisorbae 30g, Radix Et Rhizoma Rhei 30g, Radix Astragali 30g.

Add water 3L, 100 ℃ were extracted 2 hours, and leached medicinal liquid A for subsequent use;

The slag of getting it filled adds water 2.5L, and 100 ℃ were extracted 2 hours, and leached medical liquid B for subsequent use;

Merge medicinal liquid A, B, be concentrated into 80 ℃ of temperature, relative density 1.2, be cooled to room temperature after, add Borneolum Syntheticum 10g, ethanol 5L, stir, leave standstill, get supernatant, Recycled ethanol adds purified water, gets compound coptis chinensis liquid 6L;

Get compound coptis chinensis liquid, in order to the soak affected part, change dressings every other day once to disease and fully recover.

Embodiment 2

Get Rhizoma Coptidis 95g, Radix Scutellariae 28g, Cortex Phellodendri 30g, Fructus Gardeniae 28g, Radix Sanguisorbae 30g, Radix Et Rhizoma Rhei 32g, Radix Astragali 30g;

Preparation method gets compound coptis chinensis liquid with embodiment 1, in order to the soak affected part.

Embodiment 3

Get Rhizoma Coptidis 88g, Radix Scutellariae 30g, Cortex Phellodendri 32g, Fructus Gardeniae 28g, Radix Sanguisorbae 32g, Radix Et Rhizoma Rhei 32g, Radix Astragali 30g;

Preparation method gets compound coptis chinensis liquid with embodiment 1, in order to the soak affected part.

For objective evaluation clinical effectiveness of the present invention, from May in May, 1991 to nineteen ninety-five, the chronic osteomyelitis case is divided into compound coptis chinensis liquid external group of the present invention (hereinafter referred to as treatment group) and gentamycin solution external group (hereinafter referred to as matched group) at random.By the curative effect of unified each group of criterion of therapeutical effect evaluation, its result is as follows:

1, diagnostic criteria

(1) trauma infection contamination is arranged, local soft tissue infects or the acute hematogenous osteomyelitis medical history;

(2) suffer from the limb sinus tract and do not heal for a long time, have pus and (or) little sequestrum discharges;

(3) limb swelling pain or soft tissue sclerosis;

(4) the x-ray inspection have the broken ring of periosteal reaction, sclerotin and (or) osteosclerosis, sequestrum, cavity involucrum form.

Meet above 1,4 add in 1,3 any one and except bone tumor, bone tuberculosis, syphilis osteomyelitis namely consist of diagnosis.

2, inclusive criteria

The case that meets above diagnostic criteria all can be included in.

3, exclusion standard

(1) is associated with the patient of septicemia;

(2) be associated with the patient of diabetes;

(3) be associated with serious hepatorenal disease or other diseases;

(4) do not meet inclusive criteria, not in accordance with regulations medication can't be judged the not congruent result's of impact patient of curative effect or data.

4, physical data

Treatment group is totally 45 examples, male 39 examples, women 6 examples; 3～10 years old age, 5 examples, 11～19 years old 6 example, 20～49 years old 26 example, 50～70 years old 8 example; Haematogenous 20 examples, trauma infection contamination 23 examples, local soft tissue outbreaks of infection 2 examples; The February course for the treatment of is with interior 5 examples, February～1 year 18 examples, 22 examples more than 1 year.

Matched group is totally 42 examples, male 38 examples, women 4 examples; 3～10 years old age, 5 examples, 11～19 years old 10 example, 20～49 years old 19 example, 50～70 years old 8 example; Haematogenous 17 examples, trauma infection contamination 21 examples, local soft tissue outbreaks of infection 4 examples; The February course for the treatment of is with interior 8 examples, February～1 year 20 examples, 14 examples more than 1 year.

Table 1 treatment group, matched group case, sex, age (X ± SD) distribute relatively

Two groups of cases illustrate that at the difference nonsignificance of the aspects such as age, the cause of disease, the course of disease two groups of cases have homogeneity aspect the formation of age, the cause of disease, the course of disease by statistics, and two groups of cases have comparability.

5, observational technique

Treatment group is selected compound coptis chinensis liquid soak of the present invention affected part, changes dressings every day 1 time, and the state of an illness takes a turn for the better and changes dressings every other day 1 time to being completely recovered; Matched group is selected without exception, and two groups of antibiotic are used alternatingly: 4,890,000 quiet of A group penicillins, add quiet of 0.5% metronidazole 100ml 2 times every day, and every day 2 times, quiet of B group ampicillin 5g adds quiet of gentamycin 1 time every day.First-selected A group, 7 is a course for the treatment of, changes the B group the 2nd course for the treatment of, with changing the A group after full 1 course for the treatment of, by that analogy again.Above-mentioned dosage is general people's amount, and child and old man carry out decrement according to body weight, and is inactive to recovery from illness.

6, criterion of therapeutical effect

(1) cure transference cure, sinus tract closure or wound healing, the diseases such as the part is red, swollen, hot, pain disappear;

(2) produce effects transference cure, sinus tract closure or wound healing, local without performances such as red, pains, without obvious swelling and heating, but can leave over the slightly thick and local low grade fever of trouble limb;

(3) invalid symptom is without improvement, and the not closed or non-healing wounds of sinus tract increases the weight of without bone repair sign or bone destruction.

7, therapeutic outcome

Treatment group is the longest 46 days the course for the treatment of, and is the shortest 12 days, average 21 days; Cure 38 examples, account for 84.4%; Produce effects 7 examples account for 15.6%; Total effective rate 100%.All cases were followed up a case by regular visits to 1 year, 1 example recurrence.Matched group is the longest 90 days the course for the treatment of, and is the shortest 15 days, average 28.8 days; Cure 24 examples, account for 57.14%; Produce effects 14 examples account for 33.33%; Invalid 4 examples account for 9.5%.All cases were followed up a case by regular visits to 1 year, 8 example recurrences.

Table 2 liang group curative effect relatively

Group	Example number (n)	Cure example (%)	Produce effects example (%)	Not more routine (%)	Total effectively example
						Treatment group	45	38(84.4)	7(15.6)	0	45(100)
Matched group	42	24(57.14)	14(33.33)	4(9.5)	38(90.4)
						Add up to	87	62(71.26)	21(24.13)	4(4.6)	83(95.4)

Can find out from therapeutic outcome, treatment group short treating period, cure rate and total effective rate are high, relapse rate is low, and the treatment of chronic osteomyelitis and acute soft tissue injury is had good result.

Above-mentioned embodiment is only for clearly demonstrating example of the present invention; it is not the restriction to protection domain of the present invention; anyone can draw other multi-form variation or changes under enlightenment of the present invention; all apparent variation or changes of amplifying out thus all drop within protection scope of the present invention.

Claims (4)

1. a compound coptis chinensis liquid is characterized in that, described compound coptis chinensis liquid is made by the raw material of following weight (part) proportioning:

Rhizoma Coptidis 80～100, Radix Scutellariae 27～34, Cortex Phellodendri 27～34, Fructus Gardeniae 27～35, Radix Sanguisorbae 27～33, Radix Et Rhizoma Rhei 27～34, the Radix Astragali 27～34, Borneolum Syntheticum 9～12.

2. compound coptis chinensis liquid according to claim 1, it is characterized in that: described optimum weight (part) proportioning is Rhizoma Coptidis 90, Radix Scutellariae 30, Cortex Phellodendri 30, Fructus Gardeniae 30, Radix Sanguisorbae 30, Radix Et Rhizoma Rhei 30, the Radix Astragali 30, Borneolum Syntheticum 10.

3. compound coptis chinensis liquid according to claim 1, it is characterized in that: the preparation of described Rhizoma Coptidis liquid comprises the steps:

(1), get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Radix Sanguisorbae, Radix Et Rhizoma Rhei, the Radix Astragali, 100 ℃ in the water that adds 10 times of amounts extracted 2 hours, leached medicinal liquid for subsequent use, got medicinal residues;

(2), get step (1) medicinal residues, 100 ℃ in the water that adds 8 times of amounts extracted 2 hours, leached medicinal liquid for subsequent use;

(3), combining step (1), (2) medicinal liquid, be concentrated into 80 ℃ of temperature, relative density 1.1～1.3 is cooled to room temperature, adds Borneolum Syntheticum and 2 times of amount ethanol stir, and leaves standstill, and gets supernatant, Recycled ethanol adds purified water to ormal weight.

4. compound coptis chinensis liquid according to claim 3 is characterized in that, described ormal weight medicinal liquid is that every 100g Rhizoma Coptidis can prepare 6～7L medicinal liquid ratio.