CN103039455A - Synergistic insecticidal composition containing tolfenpxrad and flonicamid and application thereof - Google Patents

Synergistic insecticidal composition containing tolfenpxrad and flonicamid and application thereof Download PDF

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Publication number
CN103039455A
CN103039455A CN2011103150083A CN201110315008A CN103039455A CN 103039455 A CN103039455 A CN 103039455A CN 2011103150083 A CN2011103150083 A CN 2011103150083A CN 201110315008 A CN201110315008 A CN 201110315008A CN 103039455 A CN103039455 A CN 103039455A
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flonicamid
tolfenpyrad
synergistic insecticidal
insecticidal compositions
characterized
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CN2011103150083A
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Chinese (zh)
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CN103039455B (en
Inventor
陈文明
刘奎涛
杨晓生
沈海峰
乔璐曼
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南京华洲药业有限公司
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Abstract

The invention discloses a synergistic insecticidal composition containing tolfenpxrad and flonicamid and an application thereof. The insecticidal composition takes the tolfenpxrad and the flonicamid as main active ingredients, wherein the weight ratio of the tolfenpxrad to the flonicamid is (0.1-80):(0.5-80). The insecticidal composition has the effects of expanding a control spectrum and realizing synergy, can reduce the cost of medication, can be prepared into missible oil, wettable powder, micro-emulsion, aqueous emulsion, suspension and water dispersible granules, and can be used for controlling lepidoptera, homoptera, hymenoptera, thysanoptera or coleoptera and other various pests.

Description

A kind of Synergistic insecticidal compositions and application thereof that contains Tolfenpyrad and flonicamid

Technical field

The invention belongs to pesticide field, be specifically related to a kind of Synergistic insecticidal compositions and application thereof that contains Tolfenpyrad and flonicamid.

Background technology

Tolfenpyrad (Tolfenpyrad), chemical name: 4-chloro-3-ethyl-1-methyl-N-{[4-(4-methylphenoxy) phenyl]-methyl }-1H pyrazoles-5-carboxylic acid amides, be the off-white color pressed powder, density (25 ℃): 1.18g/cm, vapour pressure (25 ℃):<5 * 10Pa.Solvability (25 ℃): water 0.037mg/L, n-hexane 7.41g/L, toluene 366g/L, methyl alcohol 59.6g/L.Distribution coefficient (n-octyl alcohol/water) (25 ℃): log Pow 5.61.Structural formula is:

The acute toxicity of Tolfenpyrad preparation is: rat oral LD 50102 (heros), 83 (female) mg/kg; Its mouse oral LD 50104 (heros), 108 (female) mg/kg.Acute dermal toxicity is relatively low, to rat, mouse LD 50All>2000mg/kg.Lagophthalmos eyeball and skin there is moderate spread effect.

Tolfenpyrad is the novel pyrazole heterocyclic insecticidal/acaricidal agent of former Mitsubishi chemical company (its agricultural chemicals partly now belong to Japanese agricultural chemicals company) exploitation, its main mechanism is the oxidative phosphorylation that stops insect, also has ovicidal, presses down food, oviposition deterrence and bactericidal action.

Flonicamid (flonicamid), chemical name: N-cyanogen methyl-4-(trifluoromethyl) vitamin PP, structural formula is:

Flonicamid is effective to various suckings pest, and has good osmosis.It can be from root to stem, the infiltration of leaf section, but by leaf section to stem, root osmosis relatively a little less than.This medicament causes effect by hindering the insect act of sucking.Insect stops to suck after taking in medicament very soon, and is last hungry and dead.Insect according to electronics sucks behavior (EMIII) parsing, and this agent can make the lancet tissue of the sucking insects such as aphid can't insert plant tissue and cause effect.

Often there is defective in the insecticide variety that contains single component in the agricultural chemicals control of insect: use is developed immunity to drugs easily continuously, and insecticidal spectrum is narrow, can not provide comprehensive protection for crop, and peasant's drug cost is high.Can overcome to a certain extent above-mentioned shortcoming by two kinds or being combined in to a certain extent of two or more active components.Have two kinds of synergistic effect or the combination of two or more active components and be mixed, can improve preventive effect, reduce active ingredient ground dosage, save cost, slow down pest resistance occur, and can the expanding prevention spectrum, play that many worms are double to be controlled, reduce peasant's use cost.

Summary of the invention

The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid, said composition can be used for preventing and treating the various agricultural insect, such as control paddy rice rice leaf roller or vegetable aphid and thrips etc., can reach the effect that a drug is prevented and treated dissimilar insects.

Another object of the present invention provides the application of Synergistic insecticidal compositions in the preparation insecticidal materials that contains Tolfenpyrad and flonicamid.

The present invention adopts following technical scheme:

A kind of Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid, it is take Tolfenpyrad and flonicamid as main active ingredient, and wherein, the weight ratio of Tolfenpyrad and flonicamid is 0.1~80: 0.5~80.Be preferably 1~60: 1~70, more preferably 1~30: 1~30.The effective ingredient of above-mentioned Insecticidal combinations is present in the composition with the synergy effective dose.

At the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid of the present invention, the two weight percentage in this Synergistic insecticidal compositions of Tolfenpyrad and flonicamid is 2%~80%, is preferably 8%~60%, and optimum is 20%~40%.

The above-mentioned Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid take Tolfenpyrad and flonicamid as main active ingredient (active component) and insecticides adjuvant, excipients be mixed with any one formulation that allows on the agricultural chemicals.The preferred microemulsion of formulation, aqueous emulsion, wetting powder, suspending agent, missible oil and water dispersion granule.

Described auxiliary agent can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, polyoxyethylene polyoxy third rare block compound (such as farming breast 33 #), polyoxyethylene nonylphenol ether, cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (such as propane diols), deionized water etc.Above auxiliary agent and the upper known auxiliary material of other agricultural can alone or and usefulness.

Application in the insecticidal materials of the above-mentioned Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid one or more insects in preparation control Lepidoptera, Homoptera, Hymenoptera thrips or coleoptera.Especially the effect in the insecticidal materials of preparation control paddy rice rice leaf roller or vegetable aphid, aleyrodid, leafhopper or thrips is remarkable.

Synergistic insecticidal compositions antagonism Lepidoptera of the present invention, thrips insect have significant preventive effect, especially have good preventive effect for the easy various pests that produces resistance such as paddy rice rice leaf roller or thrips; And suppress insect the pesticide resistance of unitary agent (Tolfenpyrad or flonicamid) is produced and can prevent and treat simultaneously homoptera pest such as vegetable aphid, aleyrodid, leafhopper etc.

Pesticidal combination of the present invention compared with prior art, produce following beneficial effect: (1) is compared with single dose, the said composition insect has obvious Synergistic, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and significantly reduce the field dosage, effective environmental contamination reduction and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with the Tolfenpyrad single dose, produce and the use cost reduction; (6) suppress insect to the resistance enhancing of agricultural chemicals;

Embodiment

Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, carry out again field trial.

Embodiment 1:

Taking by weighing Tolfenpyrad, flonicamid, to adopt the conventional formulation method to be mixed with main active ingredient weight percentage by different proportion be 30% Tolfenpyrad flonicamid missible oil.Concrete ratio sees Table 1.

Adopt feed to add malicious method and measure Tolfenpyrad and flonicamid and composite sample thereof to the virulence of paddy rice rice leaf roller, every processing repeats 3 times, and every concentration is processed 30, uses LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

Table 1 Tolfenpyrad, flonicamid and composite sample thereof are to toxicity test and the co-toxicity coefficient of paddy rice rice leaf roller

Data show in the table, and Tolfenpyrad and flonicamid are mixed and rear the paddy rice rice leaf roller are had synergistic effect, and four listed in table proportioning co-toxicity coefficients are all much larger than 120, so Tolfenpyrad and flonicamid are mixed and have significant synergies.The synergistic effect maximum that wherein is mixed when the ratio of flonicamid and Tolfenpyrad is 5: 1 and kills the paddy rice rice leaf roller, co-toxicity coefficient is 200.12.

Embodiment 2:

Taking by weighing Tolfenpyrad, flonicamid, to adopt the conventional formulation method to be mixed with main active ingredient weight percentage by different proportion be 30% Tolfenpyrad flonicamid missible oil.Concrete ratio sees Table 2.

Adopt rice stem infusion process to measure Tolfenpyrad and flonicamid and composite sample thereof to the virulence of vegetable aphid, every processing repeats 3 times, uses LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

Table 2 Tolfenpyrad, flonicamid and composite sample thereof are to toxicity test and the co-toxicity coefficient of vegetable aphid

Data show in the table, and Tolfenpyrad and flonicamid are mixed and rear vegetable aphid are had synergistic effect, and four listed in table proportioning co-toxicity coefficients are all much larger than 120, so Tolfenpyrad and flonicamid are mixed and have significant synergies.The synergistic effect maximum that wherein is mixed when the ratio of Tolfenpyrad and flonicamid is 1: 5 and kills vegetable aphid, co-toxicity coefficient is 187.32.

Embodiment 3:

Take by weighing 5g Tolfenpyrad, 20g flonicamid, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms main active ingredient weight percentage and be 25% Tolfenpyrad flonicamid missible oil.

Adopt 3 sample product of embodiment to carry out the field trial of control in field paddy rice rice leaf roller, the contrast medicament is 15% Tolfenpyrad EC and 10% flonicamid WDG, and with clear water as blank, concrete consumption sees Table 3, and every mu of water consumption is 30kg, looks into behind the medicine 3 days, 7 days, 14 days, 28 days results, result of the test sees Table 3:

Table 3 example 3 samples are to the field test results of paddy rice rice leaf roller

3 pairs of paddy rice rice leaf roller of example have fabulous quick-acting as can be seen from Table 3, and the lasting period is more intense, in the field performance well, are the outstanding medicaments of control paddy rice rice leaf roller.

Embodiment 4:

Adopt 3 sample product of embodiment to carry out the field trial of control in field vegetable aphid, the contrast medicament is 15% Tolfenpyrad EC and 10% flonicamid WDG, and with clear water as blank, concrete consumption sees Table 4, and every mu of water consumption is 30kg, looks into behind the medicine 3 days, 7 days, 14 days, 28 days results, result of the test sees Table 4:

Table 4 example 3 samples are to the field test results of vegetable aphid

Example 3 samples have fabulous effect to vegetable aphid as can be seen from Table 4, and the lasting period is long, in the field performance well, are the outstanding medicaments that prevents vegetable aphid.

Show through indoor synergism test mensuration: by Tolfenpyrad and flonicamid built agent paddy rice rice leaf roller and vegetable aphid are all had significant synergistic insecticidal action; Field control effectiveness test shows that equally also all built agents of the present invention all are significantly higher than the effect of corresponding single dose agricultural chemicals to the insecticidal effect of rice leaf roll snout moth's larva and vegetable aphid.

Embodiment 5:

Take by weighing 0.2g Tolfenpyrad, 20g flonicamid, lignin 10g, Negel 2g, add to 100g with kaolin, above raw material is mixed in micronizer, form main active ingredient weight percentage and be 20.2% Tolfenpyrad flonicamid wetting powder.

Embodiment 6:

Take by weighing 78g Tolfenpyrad, 0.5g flonicamid, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 6g, dimethylbenzene and add to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms main active ingredient weight percentage and be 78.5% Tolfenpyrad flonicamid missible oil.

Embodiment 7:

Take by weighing 2g Tolfenpyrad, 10g flonicamid, nonyl phenol phosphate 5g, alkylphenol polyoxyethylene 4g, n-butanol 3g, the dimethylbenzene of 30g and the pyrrolidones of 20g, the xanthans of 0.1g, all the other waters are supplied 100g, n-butanol and water-soluble solution form water, and all the other component mix and blends form oil phase, slowly water are added in the oil phase under the clipper effect and go, and continue to shear 10~30 minutes, form main active ingredient weight percentage and be 12% Tolfenpyrad flonicamid aqueous emulsion.

Embodiment 8:

Take by weighing 10g Tolfenpyrad, 30g flonicamid, calcium dodecyl benzene sulfonate 5g, alkylphenol polyoxyethylene 4g, the solvent xylene of 30g and the pyrrolidones of 15g, all the other waters complement to 100g, Tolfenpyrad, flonicamid, dimethylbenzene, calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene and pyrrolidones mix and blend form homogeneous phase transparent solution, then slowly add entry and stir to form clear solution, be main active ingredient weight percentage and be 40% Tolfenpyrad flonicamid microemulsion.

Embodiment 9:

Take by weighing 4g Tolfenpyrad, 4g flonicamid, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g.The method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms main active ingredient weight percentage and be 8% Tolfenpyrad flonicamid missible oil.

Embodiment 10:

Take by weighing 3g Tolfenpyrad, 30g flonicamid, sodium lignin sulfonate 3g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.2g, ethylene glycol 10g, silica ethane 0.1g, aluminium-magnesium silicate 0.5g, water is supplied 100g, and the main active ingredient weight percentage of formation is 33% Tolfenpyrad flonicamid suspending agent under the effect of sand mill.

Embodiment 11:

Take by weighing 5g Tolfenpyrad, 60g flonicamid, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms main active ingredient weight percentage and be 65% Tolfenpyrad flonicamid missible oil.

Embodiment 12:

Take by weighing 45g Tolfenpyrad, 5g flonicamid, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g, it is 50% Tolfenpyrad flonicamid water dispersible granules that above raw material is formed main active ingredient weight percentage by the method for water dispersion granule.

Embodiment 13:

Take by weighing 25g Tolfenpyrad, 25g flonicamid, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms main active ingredient weight percentage and be 50% Tolfenpyrad flonicamid missible oil.

Claims (10)

1. Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid is characterized in that this Synergistic insecticidal compositions take Tolfenpyrad and flonicamid as main active ingredient, and wherein, the weight ratio of Tolfenpyrad and flonicamid is 0.1~80: 0.5~80.
2. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 1 is characterized in that the effective ingredient Tolfenpyrad of this Pesticidal combination and the weight ratio of flonicamid are 1~60: 1~70.
3. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 2 is characterized in that the effective ingredient Tolfenpyrad of this Pesticidal combination and the weight ratio of flonicamid are 1~30: 1~30, preferred 1: 12.
4. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 1 is characterized in that the two gross weight percentage composition in this Synergistic insecticidal compositions of described Tolfenpyrad and flonicamid is 2%~80%.
5. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 4 is characterized in that the two gross weight percentage composition in this Synergistic insecticidal compositions of Tolfenpyrad and flonicamid is 8%~60%.
6. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 5 is characterized in that the two gross weight percentage composition in this Synergistic insecticidal compositions of Tolfenpyrad and flonicamid is 20%~40%.
7. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 1 is characterized in that the auxiliary agent that allows on this Synergistic insecticidal compositions is take Tolfenpyrad and flonicamid as main active ingredient and agricultural chemicals is mixed with any one formulation.
8. the Synergistic insecticidal compositions that contains Tolfenpyrad and flonicamid according to claim 7 is characterized in that described formulation is missible oil, wetting powder, microemulsion, aqueous emulsion, suspending agent or water dispersion granule.
9. the application of Synergistic insecticidal compositions in preparing the insecticidal materials of preventing and treating one or more insects in Lepidoptera, Homoptera, Hymenoptera, thrips or the coleoptera that contains Tolfenpyrad and flonicamid claimed in claim 1.
10. application according to claim 9 is characterized in that the described application of Synergistic insecticidal compositions in the insecticidal materials of preparation control paddy rice rice leaf roller or vegetable aphid, aleyrodid, leafhopper or thrips that contains Tolfenpyrad and flonicamid.
CN201110315008.3A 2011-10-17 2011-10-17 Synergistic insecticidal composition containing tolfenpxrad and flonicamid and application thereof CN103039455B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039693A (en) * 1988-10-14 1991-08-13 Mitsubishi Kasei Corporation Pyrazole amides and insecticide and miticide containing them as active ingredient
JPH09323973A (en) * 1996-05-31 1997-12-16 Ishihara Sangyo Kaisha Ltd Production of amide-based compound or its salt
CN101700024A (en) * 2009-08-01 2010-05-05 深圳诺普信农化股份有限公司 Synergistic pesticide composition and application thereof
CN102349504A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Flonicamid-containing ultralow volume liquid agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039693A (en) * 1988-10-14 1991-08-13 Mitsubishi Kasei Corporation Pyrazole amides and insecticide and miticide containing them as active ingredient
JPH09323973A (en) * 1996-05-31 1997-12-16 Ishihara Sangyo Kaisha Ltd Production of amide-based compound or its salt
CN101700024A (en) * 2009-08-01 2010-05-05 深圳诺普信农化股份有限公司 Synergistic pesticide composition and application thereof
CN102349504A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Flonicamid-containing ultralow volume liquid agent

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