CN103039446A - Chlorothalonil nano-preparation and preparation method thereof - Google Patents

Chlorothalonil nano-preparation and preparation method thereof Download PDF

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CN103039446A
CN103039446A CN 201210581836 CN201210581836A CN103039446A CN 103039446 A CN103039446 A CN 103039446A CN 201210581836 CN201210581836 CN 201210581836 CN 201210581836 A CN201210581836 A CN 201210581836A CN 103039446 A CN103039446 A CN 103039446A
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chlorothalonil
preparation
solution
nano
method
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CN 201210581836
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Chinese (zh)
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吕建洲
宫阳阳
李科
刘照斌
姜国盛
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辽宁师范大学
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Abstract

The invention discloses a chlorothalonil nano-preparation which can improve the application effect of chlorothalonil, reduce the consumption of chlorothalonil and lower the production cost of crops, and a preparation method of chlorothalonil nano-preparation. The preparation method is performed by the following steps in sequence: dissolving powdery chlorothalonil in an acetone solution while controlling the proportion of powdery chlorothalonil to acetone solution to be 100 mg:10 ml; magnetically stirring the chlorothalonil/acetone solution at a rotation speed of 900 r/min; and ultrasonically vibrating the resulting solution at a frequency of 40 KHz for 2 h.

Description

百菌清纳米制剂及制备方法技术领域[0001] 本发明涉及一种广谱性内吸低毒杀菌剂,尤其是一种可提高百菌清的应用效果, 减少百菌清使用量、降低农作物生产成本的的百菌清纳米制剂及其制备和用途。 Chlorothalonil formulation and method for preparing nano Technical Field [0001] relates to the absorption of a broad spectrum fungicide low toxicity, especially an effect of improving the application chlorothalonil, chlorothalonil reduce the amount of, the present invention is to reduce crop chlorothalonil production cost of its preparation and uses nanometer. 背景技术[0002] 百菌清英文通用名为chlorothalonil,结构式如下: [0002] Chlorothalonil English common name chlorothalonil, the following structural formula:

Figure CN103039446AD00031

分子式:C8N2C14,化学名称:2,4,5,6-四氯_1,3-二氰基苯,其他名称为打克尼尔, Daconil-2787,大克灵,桑瓦特,克劳优,Dacotech等。 Molecular formula: C8N2C14, chemical name: 2,4,5,6-tetrachloro _1,3- dicyanobenzene, a different name for playing Ke Nier, Daconil-2787, large Kling, Sang Wate, Claudia excellent, Dacotech and so on. [0003] 百菌清是广谱、保护性杀菌剂。 [0003] Chlorothalonil is a broad-spectrum, protective fungicides. 作用机理是能与真菌细胞中的三磷酸甘油醛脱氢酶发生作用,与该酶中含有半胱氨酸的蛋白质相结全,从而破坏该酶活性,使真菌细胞的新陈代谢受破坏而失去生命力。 Mechanism of action is to occur with the fungal cell glyceraldehyde 3-phosphate dehydrogenase, the enzyme protein in the cysteine-containing phase full knot, thereby destroying the enzyme activity of the metabolism and destruction by fungal cells devitalized . 百菌清没有内吸传导作用,但喷到植物体上之后,能在体表上有良好的黏着性,不易被雨水冲刷掉,因此药效期较长,主要用于果树、蔬菜上锈病、炭疽病、白粉病、霜霉病的防治。 Chlorothalonil uptake and no effect, but then sprayed onto the plant, to have a good adhesion on the surface, is not easily washed away rain, so the efficacy of long, primarily for rust on fruit trees, vegetables, anthracnose, powdery mildew, downy mildew control. [0004] 纳米技术是在f IOOnm尺度上研究物质的机构和性质的前沿技术,其最终目标是用分子、原子以及物质在纳米尺度上的特性制造具有特定功能的产品,但迄今为止,还没有关于百菌清纳米制剂的相关报道。 [0004] Nanotechnology is a cutting-edge technology and research institutions in the properties of matter f IOOnm scale, the ultimate goal is to manufacture products having a specific function with molecules, atoms, and material properties at the nanoscale, but so far, no reports on chlorothalonil nanoformulations. 发明内容[0005] 本发明是为了解决现有技术所存在的上述技术问题,提供一种可提高百菌清的应用效果,减少百菌清使用量、降低农作物等生产成本的百菌清纳米制剂及制备方法。 SUMMARY OF THE INVENTION [0005] The present invention is made to solve the above problems of the prior art exists to provide an improved effect chlorothalonil applied to reduce the amount of chlorothalonil, reduced crop production cost and the like chlorothalonil nanoformulation and a preparation method. [0006] 本发明的技术解决方案是:一种百菌清纳米制剂的制备方法,其特征在于依次按以下步骤进行:一种百菌清纳米制剂的制备方法,其特征在于依次按以下步骤进行:a.将百菌清粉剂溶于丙酮溶液中,百菌清粉剂与丙酮溶液的用量比为100mg:10ml ;b.将百菌清丙酮溶液以转速900r/min磁力搅拌30min ;c.将所得溶液用频率为40KHz的超声波震荡震荡2h。 [0006] The technical solution of the invention is: A method for preparing nano-formulation of chlorothalonil, characterized in that the following steps sequentially performed: a method for preparing nano chlorothalonil formulation, characterized by the steps of sequentially .: a powder was dissolved in the acetone solution chlorothalonil, chlorothalonil powders with an acetone solution with an equivalent ratio of 100mg: 10ml; b chlorothalonil acetone solution at the speed of 900r / min magnetic stirring 30min; c obtained. was treated with ultrasonic agitation frequency is 40KHz shock 2h. [0007] —种如上述百菌清纳米制剂的制备方法制备的百菌清纳米制剂。 [0007] - Chlorothalonil nano preparation prepared as species chlorothalonil method for preparing the nano formulation. [0008] 本发明制备方法简单易行,所制备的百菌清纳米制剂粒度较为均匀、分散性好。 [0008] The preparation method is simple, chlorothalonil nanoformulations more uniform particle size prepared, and good dispersibility. 可使百菌清在纳米水平上发挥作用,不仅保留了百菌清的杀菌作用,而且加强了其作用效果,减少了百菌清使用量、降低了农作物的生产成本。 Chlorothalonil can play a role in the nanometer level, not only retains the bactericidal effect of chlorothalonil, and strengthened its effect, reducing the use of chlorothalonil, reduce the production cost of crops. 附图说明[0009] 图1为本发明实施例百菌清IOOppm纳米制剂IOOk倍SEM图;图2为百菌清原液7k倍SEM图。 BRIEF DESCRIPTION [0009] FIG 1 case chlorothalonil IOOppm nanoformulations IOOk × SEM embodiment of the present invention; FIG. 2 is a liquid 7k chlorothalonil × SEM. 具体实施方式[0010] 实施例1 :依次按以下步骤进行:a.秤取IOOmg购于利民化工股份有限公司的百菌清粉剂溶于IOml的丙酮溶液中,制成百菌清丙酮溶液;b.将百菌清丙酮溶液用恒温磁力搅拌器以转速900r/min磁力搅拌30min ;c.将所得溶液注入锥形瓶中,在室温条件下,用频率为40KHz的超声波震荡2h,所用超声波清洗机的机型为JCP-1004,即制得百菌清纳米制剂。 DETAILED DESCRIPTION [0010] Example 1: sequentially the following steps: a weighed powders IOOmg chlorothalonil Limin Chemical Corporation purchased solution IOml dissolved in acetone, the acetone solution prepared chlorothalonil;. . chlorothalonil B the acetone solution was stirred with a magnetic stirrer at constant speed of 900r / min magnetic 30min; c the resulting solution was poured into the conical flask, at room temperature, using a frequency of 40KHz ultrasonic vibration 2h, by the ultrasonic cleaning. machine models for JCP-1004, i.e., to prepare nano chlorothalonil formulation. [0011] 可将所得百菌清纳米制剂用蒸馏水定容,得到不同浓度的百菌清纳米制剂,可作用于植物病组织。 [0011] can be obtained chlorothalonil nanoformulations with distilled water to afford chlorothalonil nanoformulations different concentrations, the plant tissue can act on the disease. [0012] 采用国内先进S8 0100型号电镜观察本发明实施例用蒸馏水调制的IOOppm百菌清纳米制剂,IOOk倍观察结果如图1所示。 [0012] The advanced S8 IOOppm chlorothalonil nanoformulations embodiment distilled modulation type electron microscope of the embodiment 0100 of the present invention, IOOk observation times as shown in FIG. 从图1、2中可以看出百菌清原液粒子粒径为1. 5^2. 5 μ m,而本发明的百菌清纳米粒子粒径为15〜50nm之间,并且可看出百菌清纳米粒子分散均匀,物相纯净,无杂质存在。 2 it can be seen from the figure liquid chlorothalonil particle diameter of 1. 5 ^ 2. 5 μ m, and the diameter of the nanoparticles of the present invention is chlorothalonil is between 15~50nm, and may be seen that one hundred bacterial clearance nanoparticles uniformly dispersed, phase purity, free of impurities present. [0013]实验:分别使用不同浓度的百菌清纳米生物制剂和相同浓度的百菌清原剂对蔬菜上锈病、炭疽病、白粉病、霜霉病等作物进行实验处理,对比研究、观察和测定其对作物病症治疗效果的差异。 [0013] Experiment: using different concentrations of the same concentration and chlorothalonil nanoformulations chlorothalonil original biological agents on rust, anthracnose, powdery mildew, downy mildew on vegetables and other crops experimental treatments, Comparative study, observation and measurement the treatment difference in effect on crop conditions. [0014] 结果:相同环境条件下培养病症白菜(已感染霜霉病),经过本发明实施例的百菌清纳米制剂喷洒的防治效果更好。 [0014] Results: cabbage culture conditions (downy mildew infected) under the same environmental conditions, chlorothalonil nanoformulations embodiment of the present invention through the sprayed better control effect. 而对于油菜及甘蓝也是经百菌清纳米制剂处理过的防治效果更佳。 For oilseed rape and cabbage are treated with chlorothalonil nanoformulation better control effect.

Claims (2)

  1. 1. 一种百菌清纳米制剂的制备方法,其特征在于依次按以下步骤进行:a.将百菌清粉剂溶于丙酮溶液中,百菌清粉剂与丙酮溶液的用量比为IOOmg =IOml ;b.将百菌清丙酮溶液以转速900r/min磁力搅拌30min ;c.将所得溶液用频率为40KHz的超声波震荡震荡2h。 1. A method for preparing nano-formulation of chlorothalonil, characterized in that the following steps sequentially performed:. A The powder was dissolved in acetone chlorothalonil, chlorothalonil powders with an acetone solution with an equivalent ratio of IOOmg = IOml; . b the acetone solution was chlorothalonil speed 900r / min magnetic stirring 30min; c the resulting solution was treated with an ultrasonic frequency of 40KHz shock shock 2h..
  2. 2. 一种如权利要求1所述百菌清纳米制剂的制备方法制备的百菌清纳米制剂。 2. A chlorothalonil nanoformulation preparation of the formulation of chlorothalonil nanometer claim 1.
CN 201210581836 2012-12-28 2012-12-28 Chlorothalonil nano-preparation and preparation method thereof CN103039446A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1377578A (en) * 2002-04-23 2002-11-06 四川龙蟒福生科技有限责任公司 Plant growth regulating composition having resisting and growth promoting function
CN1985590A (en) * 2005-12-20 2007-06-27 云南农业大学 Chlorothalonil microemulsion and its preparing process
CN101569304A (en) * 2008-04-29 2009-11-04 张志勋 Paclobutrazol suspension concentrate and preparation method thereof
CN101909733A (en) * 2007-12-28 2010-12-08 金伯利-克拉克环球有限公司 Ultrasonic treatment chamber for particle dispersion into formulations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1377578A (en) * 2002-04-23 2002-11-06 四川龙蟒福生科技有限责任公司 Plant growth regulating composition having resisting and growth promoting function
CN1985590A (en) * 2005-12-20 2007-06-27 云南农业大学 Chlorothalonil microemulsion and its preparing process
CN101909733A (en) * 2007-12-28 2010-12-08 金伯利-克拉克环球有限公司 Ultrasonic treatment chamber for particle dispersion into formulations
CN101569304A (en) * 2008-04-29 2009-11-04 张志勋 Paclobutrazol suspension concentrate and preparation method thereof

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