CN103028031A

CN103028031A - Traditional Chinese medicine granule for preventing salmonellosis avium and preparation method thereof

Info

Publication number: CN103028031A
Application number: CN 201110298338
Authority: CN
Inventors: 董根荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-09-30
Filing date: 2011-09-30
Publication date: 2013-04-10

Abstract

The invention provides a traditional Chinese medicine granule for preventing salmonellosis avium and a preparation method thereof, wherein the granule is prepared from 50-200g of coptis chinensis, 50-200g of scutellaria baicalensis, 50-200g of golden cypress, 30-120g of rhizoma anemarrhenae, 30-120g of fructus gardeniae, 30-120g of divaricate saposhnikovia root, 30-120g of cortex lycii radicis, 30-120g of semen plantaginis and 30-100g of immature bitter oranges. With the adoption of the traditional Chinese medicine granule for preventing the salmonellosis avium and the preparation method thereof, the medicine residue problem of the existing antibacterial agents is overcome, so that the demand on the production of green and nuisanceless animal products paid more and more attention by people can be met; the traditional Chinese medicine granule for preventing the salmonellosis avium as a pure traditional Chinese veterinary medicine preparation generates no any medicine residue and no toxic or side effects to an organism.

Description

A kind of Chinese medicine granules that prevents the fowl salmonellosis and preparation method thereof

Technical field: the present invention is a kind of Chinese medicine granules that prevents the fowl salmonellosis and preparation method thereof, belongs to the technical field of veterinary drug.

Technical background: salmonellosis has another name called paratyphoid fever (paratyphoid), be various animals by the bacterial disease general name of Salmonella, face to examine and show as septicemia and enteritis more.By the caused Pullorum Disease that is called of Pullorum Disease Salmonella, by the salmonellal avian typhoid that becomes of fowl typhoid, the caused poultry disease of Salmonella that has other amphitrichous to move then is referred to as avian paratyphoid.The fowl salmonellosis is at ubiquity all over the world, and is very large to the hazardness of aviculture.

Existing century-old history since Salmon in 1885 finds Salmonella. many scholars conduct extensive research the biological characteristics of Salmonella.The antibacterial of Salmonella can be divided into the host and adapt to serotype and nonhost adaptation serotype 2 large classes according to its infection scope to the host.The former host to its adaptation has pathogenic, comprises Salmonella abortus equi, bacillus paratyphi abortus, Salmonella gallinarum, salmonella paratyphi (A.C), Pullorum Disease Salmonella, salmonella typhi; Latter has pathogenic to multiple host, comprise that Salmonella typhimurium, Salmonella anatis, Dare are in order to do Salmonella, Salmonella enteritidis, Newport Salmonella, moscow' tennessee etc.As for Salmonella choleraesuls and salmonella dublin, originally thinking has host's adaptability to pig and cattle respectively, recently finds also can cause a disease to other hosts.Although the serotype of Salmonella is a lot, common harm people and animals' nonhost adapts to serotype and only has kind more than 20, adds that the host adapts to serotype, only more than 30 plants only.This genus antibacterial has certain resistance to factors such as drying, corruption, daylight, can survive a few weeks longer or several months under external condition.

The fowl salmonellosis often forms the propagation circulation of very complex.Sick fowl, the fowl that carries disease germs are the main sources of infection.Multiple route of transmission is arranged, and modal is to propagate by the ovum that carries disease germs.If infected chicken is not treated, then most of dead, the anti-chicken that crosses primary disease carries disease germs for a long time, also can lay eggs after growing up, and ovum carries disease germs again, if, then can be handed down from age to age again and again during as hatching egg with this.

Salmonella is the important diseases of harm aviculture, it wherein mainly is the Pullorum Disease Salmonella, secondly the fowl typhoid Salmonella is the Salmonella typhimurium that causes that poult paratyphoid fever infects, moscow' paratyphi B, Salmonella choleraesuls, Salmonella enteritidis, Salmonella anatis is since finding Salmonella gallinarum, researcher has just been used multi-medicament and has been treated salmonellosis of chicken, and using maximum is antibacterials.Yet because of being widely used of antibiotic property medicine, the insensitivity bacterial strain is increased gradually, brought very large difficulty for treatment and prevention work, this has become a global problem.Proved that at present the R factor is a genetic factor in the insensitive Salmonella somatic cell of antibiotic property medicine a kind of R factor being arranged, it can entail the next generation with the drug resistance that this bacterial strain produces.Chinese herbal medicine is low with its residual hazard, and can regulate the immune function of body and be difficult for produce the advantage such as drug resistance, more skillful in some disease in control, the simultaneously unlimited variation of the complexity of medicinal herb components, of a great variety, combination can be used for tackling the resistant mutation of antibacterial.

This shows, the fowl salmonellosis is to endanger very large a kind of disease, brings serious economic loss to the raiser.For this situation, develop a kind of safe and effective, the thing that the little Chinese medicine preparation of side effect has just become people to be badly in need of solving.

Summary of the invention:

The object of the invention is to: a kind of Chinese medicine granules that prevents the fowl salmonellosis and preparation method thereof is provided; The present invention is granulation agent such as Rhizoma Coptidis, Radix Scutellariaes, the compatibility science, and dosage form selection is reasonable, and preparation technology can better keep effective ingredient, and therapeutical effect is good, extensive market.

The present invention consists of like this: it is to be made by Rhizoma Coptidis 50-200g, Radix Scutellariae 50-200g, Cortex Phellodendri 50-200g, Rhizoma Anemarrhenae 30-120g, Fructus Gardeniae 30-120g, Radix Saposhnikoviae 30-120g, Cortex Lycii 30-120g, Semen Plantaginis 30-120g, Fructus Aurantii Immaturus 30-100g.Specifically: it is to be made by Rhizoma Coptidis 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Rhizoma Anemarrhenae 80g, Fructus Gardeniae 80g, Radix Saposhnikoviae 80g, Cortex Lycii 80g, Semen Plantaginis 80g, Fructus Aurantii Immaturus 50g.

The preparation method of the Chinese medicine granules of described prevention fowl salmonellosis: get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, add the water that 6-12 doubly measures, soak 0.5-2h, reflux, extract, 1-3 time, each 1-3h, merge extractive liquid,, concentrated, add 80-95% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, adding adjuvant granulates, drying, the granulate packing, and get final product.Selection process is as follows: get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, the water that adds 10 times of amounts, soak 1h, reflux, extract, 2 times, each 2h, merge extractive liquid,, concentrated, add 95% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, add the sucrose of same amount, the dextrin of 0.5 times of amount, fully behind the mix homogeneously, spray the ethanol with 75%, the ethanol straying quatity is 10% of mixture, cross sieve No. 1, put into drying baker, 55～65 ℃ suitable, time is 1h, and get final product.

We are take Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri as monarch drug; Be aided with the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii and the relieving stranguria by diuresis of clearing away heat-fire, inducing diaphoresis to dispel wind, nourishing YIN for decreasing fever, the Semen Plantaginis that the promotion bacterial endotoxin is discharged; Assistant is made the Fructus Aurantii Immaturus with invigorating the stomach and promoting digestion, reducing swelling and alleviating pain.Full side has heat-clearing and toxic substances removing, anti-inflammation, and removing heat from blood detumescence effect, being used for the treatment of the salmonellal disease of fowl has good efficacy.

In the research process of extraction process, to find through trial test, the principal element that affects active constituent content and yield of extract result has the concentration of ethanol when decocting extraction time, aqueous solvent consumption, precipitate with ethanol.As evaluation index, can reflect the general status of extraction with yield of extract; As evaluation index, then can reflect the extraction situation of principal agent with active constituent content, the two combines, and is not only comprehensive but also emphasis is arranged investigated the extraction effect of ingredients in the prescription, thereby instructs better the preferred of preparation process conditions.Through the Optimized by Orthogonal Test process conditions, the final water of selecting to add 10 times of amounts soaks 1h, reflux, extract, 2 times, and each 2h, merge extractive liquid,, concentrated, add 95% ethanol remove impurity.This technique yield of extract is suitable, and active constituent content is high, and flow process is simple, is fit to large-scale production.

The dosage form that this product is selected is granule, why select this dosage form, reason is as follows: present most herbal medicines are take powder, powder as main, be unfavorable for the absorption of poultry, make modern preparation granules agent by adopting effective component extracting, improve the utilization rate of Chinese crude drug, make product dosage accurately, dissolving rapidly, be convenient to absorb, rapid-action, no drug residue, reached the requirement of green veterinary drug.The disintegrate stripping is fast, mouthfeel good, carry preserve convenient, dose is little, stable in properties and Sugarless type are the main directions of present Chinese medicinal granule and development thereof, Chinese medicine granules has a extensive future.

The processing technology of granule is generally investigated from aspects such as the color and luster of mouldability, granule, hardness.Although the supplementary product kind of granule is various, many novel adjuvants occur in succession, and price is more expensive mostly, has increased production cost.Be used as at present the adjuvant of production granule except minority is used starch or medicated powder, generally take Icing Sugar as main.Particularly the medicine bitter in the mouth such as the Cortex Phellodendri in the prescription, Rhizoma Coptidis select the sucrose powder more to can be used as correctives.The consumption of blend proportion, adhesive ethanol of supplementary material and concentration have been investigated to the impact of the processing technology of granule.Thick paste is with after dextrin mixes by a certain percentage, and viscosity is large when making granule again, is difficult for sieving, and sieving rate is low, and waste is large, and color and luster is inhomogeneous behind the particle drying of making, and caking phenomenon is arranged, bitter in the mouth.Thick paste easily sieves with after sucrose mixes, and sieving rate is high, and the granule color and luster is even, is of moderate size, and fine powder is few, places the easy moisture absorption after dry and slight caking is arranged.When extract, sucrose, dextrin mixed with 1: 1: 0.5, be fit to the preparation of this granule.

Can find out from the experiment that prevents and treats tentative Salmonella enteritidis disease, this compound Chinese medicinal preparation is by the effective clinical symptoms of the sick fowl of infection control of administration in the drinking-water, and the reduction mortality rate promotes the rehabilitation of disease fowl, and therapeutic effect is good.

Concrete embodiment:

Embodiments of the invention 1:

Rhizoma Coptidis 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Rhizoma Anemarrhenae 80g, Fructus Gardeniae 80g, Radix Saposhnikoviae 80g, Cortex Lycii 80g, Semen Plantaginis 80g, Fructus Aurantii Immaturus 50g

Get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, the water that adds 10 times of amounts, soak 1h, reflux, extract, 2 times, each 2h, merge extractive liquid,, concentrated, add 95% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, add the sucrose of same amount, the dextrin of 0.5 times of amount, fully behind the mix homogeneously, spray the ethanol with 75%, the ethanol straying quatity is 10% of mixture, cross sieve No. 1, put into drying baker, 55～65 ℃ suitable, time is 1h, namely gets granule.Mixed drink.Per 2 premium on currency add this product 1g, one day twice, freely drink.

Embodiments of the invention 2:

Rhizoma Coptidis 5g, Radix Scutellariae 50g, Cortex Phellodendri 50g, Rhizoma Anemarrhenae 30g, Fructus Gardeniae 30g, Radix Saposhnikoviae 30g, Cortex Lycii 30g, Semen Plantaginis 30g, Fructus Aurantii Immaturus 30g

Get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, the water that adds 6 times of amounts soaks 0.5h, reflux, extract, 1h, extracting solution is concentrated, add 80% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, adding adjuvant granulates, drying, the granulate packing, and get final product.

Embodiments of the invention 3:

Rhizoma Coptidis 200g, Radix Scutellariae 200g, Cortex Phellodendri 200g, Rhizoma Anemarrhenae 120g, Fructus Gardeniae 120g, Radix Saposhnikoviae 120g, Cortex Lycii 120g, Semen Plantaginis 120g, Fructus Aurantii Immaturus 100g

Get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, add the water of 12 times of amounts, soak 2h, reflux, extract, 3 times, each 3h, merge extractive liquid,, concentrated, add 85% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, adding adjuvant granulates, drying, the granulate packing, and get final product.

Claims

1. Chinese medicine granules that prevents the fowl salmonellosis, it is characterized in that: it is to be made by Rhizoma Coptidis 50-200g, Radix Scutellariae 50-200g, Cortex Phellodendri 50-200g, Rhizoma Anemarrhenae 30-120g, Fructus Gardeniae 30-120g, Radix Saposhnikoviae 30-120g, Cortex Lycii 30-120g, Semen Plantaginis 30-120g, Fructus Aurantii Immaturus 30-100g.

2. according to the Chinese medicine granules of prevention fowl claimed in claim 1 salmonellosis, it is characterized in that: it is to be made by Rhizoma Coptidis 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Rhizoma Anemarrhenae 80g, Fructus Gardeniae 80g, Radix Saposhnikoviae 80g, Cortex Lycii 80g, Semen Plantaginis 80g, Fructus Aurantii Immaturus 50g.

3. according to the preparation methoies of the Chinese medicine granules of claim 1 or 2 described prevention fowl salmonellosiss, it is characterized in that: get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus and be ground into coarse powder, add the water that 6-12 doubly measures, soak 0.5-2h, reflux, extract, 1-3 time, each 1-3h, merge extractive liquid,, concentrated, add 80-95% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, add adjuvant and granulate drying, the granulate packing, and get final product.

4. according to preparation method of preventing the Chinese medicine granules of fowl salmonellosis claimed in claim 3, it is characterized in that: get Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Saposhnikoviae, Cortex Lycii, Semen Plantaginis, Fructus Aurantii Immaturus is ground into coarse powder, adds the water of 10 times of amounts, soaks 1h, reflux, extract, 2 times, each 2h, merge extractive liquid,, concentrated, add 95% ethanol, quiet heavy, get the supernatant Recycled ethanol to the thick paste shape, add the sucrose of same amount, 0.5 the dextrin of doubly measuring, fully behind the mix homogeneously, spray is with 75% ethanol, and the ethanol straying quatity is 10% of mixture, crosses sieve No. 1, put into drying baker, 55～65 ℃ suitable, and the time is 1h, and get final product.