CN103006528A - Preparation method for acne treatment emulsion - Google Patents
Preparation method for acne treatment emulsion Download PDFInfo
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- CN103006528A CN103006528A CN2012105605957A CN201210560595A CN103006528A CN 103006528 A CN103006528 A CN 103006528A CN 2012105605957 A CN2012105605957 A CN 2012105605957A CN 201210560595 A CN201210560595 A CN 201210560595A CN 103006528 A CN103006528 A CN 103006528A
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Abstract
The invention discloses a preparation method for acne treatment emulsion, and belongs to the field of cosmetics. The acne treatment emulsion comprises the following components: component A comprising propylene glycol, xanthan gum and first solvent; component B comprising 2-hydroxyethanesulphonic acid hexyl ether, vitamin B6 and second solvent; component C comprising plant extract, azelaic acid derivatives, dendranthema indica (L.) des moul, salicylic acid, ginseng extract, vitamin E and preservative agent. The preparation method of the acne treatment emulsion comprises the following steps: firstly, the component A and the component B are dissolved completely respectively and then mixed uniformly; secondly, component C is added and stirred to mix the three components uniformly; and thirdly, after cooling to a certain temperature, sampling inspection is carried out to obtain the finished product of the acne treatment emulsion. The acne treatment emulsion has the functions of treating acne, whitening and nourishing skin, moisturizing, reducing oil secretion, and promoting cellular metabolism, the effect is obvious, the action is fast, no acne scar is left after healing, and the acne is not easy to relapse; and the acne treatment emulsion is a cosmetic which is used for preventing and treating acne and whitening skin.
Description
Technical field
The present invention relates to cosmetic field, especially relate to a kind of preparation method of acne-removing liquid.
Background technology
Acne is commonly called as comedo, is chronic inflammation pilosebaceous unit disease, is one of modal disease of department of dermatologry.
The main cause that skin produces the seat skin ulcer is:
1, cause owing to smegma is vigorous oils and fats too much, corse sweat pore or obstruction, cuticle thickening, so, oils and fats is gradually toward the cortical surface protuberance, the summit oxidation that has so just caused oils and fats to stop up pore, protuberance becomes black, cause antibacterial in pore and oils and fats stirs and is combined, made under anaerobic conditions amount reproduction of a skin ulcer propionibacterium, caused again the inflammation antibacterial to be invaded, become pustule, tuberosity, last whole hair follicle reddens, inflammation.
2, the dryingization of skin also is the formation reason of a skin ulcer, and is too dry because the skin water deficient, for moist skin, and oils and fats that on the contrary can supersecretion.
Aspect anti-acne, need to set about from following several respects: the moistening effect that 1) improves skin; 2) the oils and fats balance of regulation of skin suppresses the too much secretion of sebum; 3) suppress a breeding of skin ulcer propionibacterium; 4) has certain antiinflammatory action; 5) dispel the pox seal.
Acne removing product effect in the market is more single, can not comprehensively nurse the seat skin ulcer of skin.
Summary of the invention
For the deficiencies in the prior art, problem to be solved by this invention is to propose a kind of acne-removing liquid, and the present invention is used for the prophylactic treatment comedo, and is seamless without pox after curing.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of acne-removing liquid is characterized in that, by weight percentage, comprises following component:
A component: propylene glycol 3%～7%, HANSHENGJIAO 0.8%～2%, the first deionized water 55%～65%;
B component: two isethionic acid hexyl ethers 0.05%～0.1%, vitamin B6 0.2%～0.9%, the second deionized water 3%～7%;
C component: plant extraction liquid 15%～25%, azelaic acid derivant 1%～4%, Herba Dendranthematis indici dimension element 2%～5%, salicylic acid 0.2%～1%, Radix Ginseng extract 0.5%～2%, vitamin E 0.3%～1.0%, germall BP 0.1%～0.5%, lavandula angustifolia essence.
Preferably, described plant extraction liquid is one or more in Flos Lonicerae, Aloe, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Semen Plantaginis, the Fructus Kochiae, Fructus Cnidii, Rhizoma Coptidis, Concha Margaritifera, Radix Curcumae and the Radix Stemonae.
A kind of preparation method of acne-removing liquid is characterized in that, may further comprise the steps:
1) described A component is heated to temperature T
1Be 85 ℃, enable simultaneously agitator and stir, treat its dissolve complete;
2) with described B component in temperature T
2Dissolving is stirred with described agitator when being 25 ℃, treats its dissolve complete;
3) use cooling water to stir the A component behind the dissolve complete in the described step 1 and be cooled to temperature T
3When being 40～50 ℃, add the B component behind the dissolve complete in the described step 2, stir while adding, after described B component adding is finished, start homogenizer emulsifying 5～15 minutes;
4) described C component is added in the mixture that obtains in the described step 3, stir while adding, treat that it dissolves fully, stir, be evacuated to liquid level still;
5) open the interlayer cooling water, be cooled to temperature T
4Described acne-removing liquid is namely made in 35～40 ℃ of dischargings.
Preferably, described temperature T 3 is 40～45 ℃.
Preferably, emulsifying 10～15 minutes in the described step 3.
Preferably, the mixing speed of described blender is 2800～3000 rev/mins.
Preferably, described homogenizing speed is 1200～1400 rev/mins.
The invention has the beneficial effects as follows: the present invention has the function for the treatment of comedo and skin whitening, its successful, effect is fast, rear without pockmark, be not easy recurrence, and have skin care, moisturizing, minimizing fat secretion concurrently, promote the function of cellular metabolism, the present invention is a kind of cosmetics for prophylactic treatment seat skin ulcer and skin whitening.
The specific embodiment
Example of the present invention is can not limit the present invention to explanation of the present invention, in the implication suitable with the present invention and any change and the adjustment in the scope, all should think within the scope of the invention.
The present invention will be further described below in conjunction with embodiment.
Embodiment 1
A kind of acne-removing liquid is characterized in that, by weight percentage, comprises following component:
A component: propylene glycol 3%～7%, HANSHENGJIAO 0.8%～2%, the first deionized water 55%～65%;
B component: two isethionic acid hexyl ethers 0.05%～0.1%, vitamin B6 0.2%～0.9%, the second deionized water 3%～7%;
C component: plant extraction liquid 15%～25%, azelaic acid derivant 1%～4%, Herba Dendranthematis indici dimension element 2%～5%, salicylic acid 0.2%～1%, Radix Ginseng extract 0.5%～2%, vitamin E 0.3%～1.0%, germall BP 0.1%～0.5%, lavandula angustifolia essence 0.05%～0.1%.
Described plant extraction liquid is one or more in Flos Lonicerae, Aloe, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Semen Plantaginis, the Fructus Kochiae, Fructus Cnidii, Rhizoma Coptidis, Concha Margaritifera, Radix Curcumae and the Radix Stemonae.
A kind of preparation method of acne-removing liquid may further comprise the steps:
1) described A component is heated to temperature T
1Be 85 ℃, enable simultaneously agitator and stir, treat its dissolve complete;
2) with described B component in temperature T
2Dissolving is stirred with described agitator when being 25 ℃, treats its dissolve complete;
3) use cooling water to stir the A component behind the dissolve complete in the described step 1 and be cooled to temperature T
3When being 40 ℃, add the B component behind the dissolve complete in the described step 2, stir while adding, after described B component adding is finished, start homogenizer emulsifying 5 minutes;
4) described C component is added in the mixture that obtains in the described step 3, stir while adding, treat that it dissolves fully, stir, be evacuated to liquid level still;
5) open the interlayer cooling water, be cooled to 35 ℃ of dischargings, namely make described acne-removing liquid.
In the present invention, the effect of each component is respectively: propylene glycol is used for making solvent and the softening agent of acne-removing liquid in the present invention generally as hygroscopic agent, antifreeze, lubricant; HANSHENGJIAO plays thickening, suspension, emulsifying, stable effect; The own sulfonic acid hexyl ether of dihydroxy is used for the antibacterial of skin in the present invention, goes the acne effect good, also can make antiseptic; Vitamin B6 is the constituent of some coenzyme in the human body, participates in multiple metabolic response, especially with amino acid metabolism substantial connection is arranged, and produces antibody, regulates the central nervous system, keeps in the present invention skin health.
Chinese medicine among the present invention all meet " Chinese pharmacopoeia standard, composition principle of the present invention be according to the property of each flavor Chinese medicine, distinguish the flavor of, return, through, function cures mainly and the four diagnostic methods of Chinese medicine eight just, the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Described plant extraction liquid is the extracting solution of one or more compositions in Flos Lonicerae, Aloe, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Semen Plantaginis, the Fructus Kochiae, Fructus Cnidii, Rhizoma Coptidis, Concha Margaritifera, Radix Curcumae and the Radix Stemonae.Extraction is by solvent (such as ethanol) processing, distillation, dehydration, withstanding pressure or centrifugal action, or produces (such as constituent or juice) by other chemistry or mechanical technology process from material.Plant extraction liquid is by chemistry or mechanical technology process, the separating substances various compositions out such as the fiber of extraction plant the inside, elite, nourishing stock solution.
Flos Lonicerae: enjoy the title of " herbal medicine shop fairyhood ", contain cyclohexanhexanol, flavonoid, inositol, Saponin and tannin etc., have heat-clearing and toxic substances removing, strengthen cellular immune function and broad-spectrum antibacterial action, can effectively effect a radical cure the phenomenons such as a skin ulcer, acne, blackhead.
Flos Chrysanthemi Indici: include asterin, Coumarins, yejuhua lactone, have heat-clearing and toxic substances removing, antibacterial action, treatment furuncle, carbuncle, erysipelas etc.
Aloe: have the skin contraction of making, softization, moisturizing, antiinflammatory, bleaching, skin and absorb the performance of compacting, remove in addition sclerosis, keratinization, improve the effect of scar, can not only prevent little wrinkle, eye pouch, cutis laxa, can also keep skin wetness, tender and lovely, simultaneously, can also treat scytitis, acne, freckle, seat skin ulcer and scald, knife injury, insect bite etc. are also had good curative effect.
The Rhizoma Atractylodis Macrocephalae: contain the compositions such as volatile oil (atractylone, atractyloide, mannan, aminoacid), have antioxidation, antibiotic, brighten the pharmacological actions such as bright color, immunostimulant and adjusting immunity, can make freckle eliminate gradually, live in retirement.
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, heat-clearing and toxic substances removing antiinflammatory are used for seat skin ulcer, lump in the abdomen, carbuncle, sore etc.
Semen Plantaginis: relieving stranguria by diuresis has the effect that activates skin.
The Fructus Kochiae: clearing away damp-heat is used for the damp and hot pruritus of skin.
Fructus Cnidii: contain osthole, volatile oil (left-handed pinene and different sour borneol acetate) etc. have hormone-like effect, and can suppress infusorian, acrothesium floccosum, Newcastle virus, influenza virus, and its extract still has the ascarifuge effect.Effect with dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, invigorating kidney qi.
Rhizoma Coptidis: contain the compositions such as alkaloid, obacunone, obakulactone, eliminating fire and detoxication, heat clearing and damp drying, antibacterial, antibiotic and antiviral, protozoacide, anti-acne, the effect of adjusting oils and fats are arranged, row pyretic toxicity in the time of can treating, high heat agitation, aphtha, carbuncle are treated the diseases such as malicious.
Concha Margaritifera: main component has calcium carbonate, taurine, trace element, aminoacid (glycine, methionine, alanine, leucine, glutamic acid etc.), effectively balance the body nervus centralis and endocrine.Help to improve skin quality comprehensively and enduringly, have speckle dispelling, except pox, beauty treatment, delay senility, improve human endocrine, enhance metabolism, the effect of health invigorating, whitening, bright color.Be applicable to patient with chloasma.
Radix Curcumae: the congestion of dispelling, skin moisture-keeping effect.
The Radix Stemonae: be rich in alkaloid, the effect of parasite killing acaricide is arranged.
Azelaic acid derivant is the potassium salt for preparing by Azelaic Acid and aminoacid reaction, is Azelaic Acid aminoacid potassium salt, and its structural formula is R1-CO (CH
2)
7CO-R2-COOK, it has both sexes, water-soluble, low concentration is active, the characteristics of fabulous chemical stability and good compatibility, it is a kind of multi-functional cosmetics novel material, plays in the present invention whitening and speckle dispelling, regulates oils and fats and moisture-keeping function.
Herba Dendranthematis indici dimension element (SHF) is that a kind of the extraction from wild chaste tree Compositae shade plant root made with extra care the composite extract that forms, and it contains several amino acids, Saponin class and Herba Dendranthematis indici dimension element etc.The somatic immunologic function of enhanced machine and disease-resistant change effect are arranged, and particularly its Main Ingredients and Appearance Herba Dendranthematis indici dimension element claims again Herba Dendranthematis indici root system dimension element.Because the molecular structures of two hydroxyls of its uniqueness and two amino, can effectively activate the immunologic function of Skin Cell, be the anti-sensitizer of newfound a kind of desirable immunity enhancement type in recent years, play in the present invention anti-allergic effects.
Salicylic acid can be used for sensitivity, seborrhea skin exfoliation, and salicylic acid has the liposoluble characteristic, effect can be locked in the shallow-layer cutin, can not affect active epidermis cell.Salicylic acid is as keratolytic in the present invention, and is antipruritic, antifungic action.
Important ingredient is Radix Ginseng total saponins in the Radix Ginseng extract, and Radix Ginseng total saponins is to extract refining forming from the root of Araliaceae Radix Ginseng, stem and leaf, and it is rich in 18 kinds of Saponins, is dissolved in 80 ℃ water, and is soluble in ethanol.For a long time clothes can life lengthening, and can physical strength reinforcing; The cold-and-heat resistent stress is arranged.Have simultaneously the vigor that strengthens the human body surface cell, suppress the old and feeble effect that waits.Radix Ginseng extract can be used for speckle dispelling, reduces wrinkle, activates Skin Cell, strengthens skin elasticity in the present invention.
Vitamin E (Vitamin E) is a kind of fatsoluble vitamin, claims again tocopherol, is one of topmost antioxidant, is dissolved in the organic solvents such as fat and ethanol, and is water insoluble, and heat, acid are stablized, unstable to alkali, responsive to oxygen, insensitive to heat.Play in the present invention the activation Skin Cell, effectively reduce the generation of wrinkle, the effect of the appearance that retains youth.
The daily antiseptic of selecting has benzalkonium bromide or germall BP, and the chemical name of germall BP is diazolidinyl urea or IPBC (IPBC), and preferred preservative is germall BP among the present invention.
A mainly has been solvent action mutually, and B is take chemical composition as main mutually, and C is take medicinal herb components as main mutually, and separately the purpose of A phase, B phase, C phase mainly is in order better to dissolve all compositions of prescription.Selected C component also comprises essence among the present invention, the optional lavandula angustifolia essence of essence, Fructus Citri Limoniae essence or aloe flavour, and preferred essence is lavandula angustifolia essence in this enforcement.
Select temperature T in the preparation method step 1 among the present invention
1Be 85 ℃, reason is that the too low meeting of temperature makes the A components dissolved incomplete, and the too high A component of temperature can vapor away; Select temperature T in the step 2
2Be 25 ℃, reason is that the too low meeting of temperature makes the B components dissolved incomplete, and the too high A component of temperature can vapor away; What select during emulsifying in the step 3 is the emulsifying material-compound tank, and itself is equipped with vacuum extractor and intermediate water device, satisfies finishing of step 4 and step 5, thereby makes the acne-removing liquid finished product.In preparation process of the present invention, the model of used blender is: ZGR100, manufacturer is Xiang Machinery Plant of Light Industry in Wenzhou, the mixing speed of described blender is 2800～3000 rev/mins, described homogenizing speed is 1200～1400 rev/mins, the mixing speed of blender described in the present invention is preferably 2900 rev/mins, and described homogenizing speed is preferably 1300 rev/mins.
Embodiment 2
Identical with embodiment 1, the preparation method difference of described acne-removing liquid is:
Being cooled to temperature in the described step 3 is 45 ℃.
Embodiment 3
Identical with embodiment 1, the preparation method difference of described acne-removing liquid is:
Being cooled to temperature in the described step 3 is 50 ℃.
Embodiment 4
Identical with embodiment 2, the preparation method difference of described acne-removing liquid is:
Start homogenizer emulsifying 8 minutes in the described step 3.
Embodiment 5
Identical with embodiment 2, the preparation method difference of described acne-removing liquid is:
Start homogenizer emulsifying 10 minutes in the described step 3.
Embodiment 6
Identical with embodiment 2, the preparation method difference of described acne-removing liquid is:
Start homogenizer emulsifying 12 minutes in the described step 3.
Embodiment 7
Identical with embodiment 2, the preparation method difference of described acne-removing liquid is:
Start homogenizer emulsifying 15 minutes in the described step 3.
Embodiment 8
Identical with embodiment 5, the preparation method difference of described acne-removing liquid is:
Discharging when being cooled to 38 ℃ in the described step 5 namely gets acne-removing liquid.
Embodiment 9
Identical with embodiment 5, the preparation method difference of described acne-removing liquid is:
Discharging when being cooled to 40 ℃ in the described step 5 namely gets acne-removing liquid.
Embodiment 10
The present invention meets national cosmetic hygienic standard GB7916-1987, and the acne-removing liquid of the different preparation conditions of existing just embodiment 1-9 is done the experiment of healing property effect.
Clinical effectiveness: anti-acne.
Concrete operation method: existing is to do clinical experiment in 19～21 years old to 90 people's ages, divide equally is 9 groups, every group of 10 people, allow respectively every group of people on probation embodiment 1～9, concrete operation method is for to be applied in the affected part with acne-removing liquid, application area take greater than ill area as good, for not affecting patient's work or study, can utilize treat, the rear warm water that gets up morning cleans and gets final product the length of one's sleep in the evening.The course for the treatment of: must not be less than 100 hours, treatment time puts in place, can not rebound after the healing.Table 1 is the therapeutic effect comparison sheet of embodiment 1～9, and is as shown in table 1.
The therapeutic effect comparison sheet of table 1 embodiment 1～9
| Embodiment | Every group of number | Therapeutic effect | Cure rate (%) | Remarks |
| 1 | 10 | Generally | 78 | 1 Genus Homo anaphylaxis is failed to respond to any medical treatment |
| 2 | 10 | Good | 90 | ? |
| 3 | 10 | Generally | 80 | ? |
| 4 | 10 | Generally | 80 | ? |
| 5 | 10 | Good | 90 | ? |
| 6 | 10 | Generally | 80 | ? |
| 7 | 10 | Generally | 80 | ? |
| 8 | 10 | Best | 100 | ? |
| 9 | 10 | Generally | 80 | ? |
As can be seen from Table 1, embodiment 8 therapeutic effect are best, and optimum preparating condition is that chilling temperature is 45 ℃ in the described step 3, and described emulsifying agent homogenizing time is 10 minutes, and 38 ℃ of dischargings namely get acne-removing liquid in the described step 5, are cooled to temperature T
4The discharging formed product is best in the time of 38 ℃, and is the most stable.
Embodiment 11
Embodiment 8 prepared acne-removing liquids are done performance test, and its concrete tables of data sees Table 2, and table 2 is acne-removing liquid performance test table.
Table 2 acne-removing liquid performance test table
| Performance Detection | Embodiment 8 |
| Ph value (25 ℃) | 5.0～7.0 |
| Viscosity (25 ℃, mpa.s) | Qualified |
| Centrifugal (38 ℃, 300r/min, 30min) | Qualified |
| Density (20 ℃, g/ml) | Qualified |
| Turbidity (5-10 ℃) | Qualified |
| Performance Detection | Embodiment 8 |
| Foam volume (40 ℃, mm) | Qualified |
| Cold-resistant (5 ℃-15 ℃, 48h then observe) | Without unusual |
| Heat-resisting (48 ± 1 ℃, 48h then observe) | Without unusual |
| Total number of bacteria (cfu/g) | ＜10 |
The present invention has the function for the treatment of comedo and skin whitening, its successful, and effect is fast, rear without pockmark, be not easy recurrence, and have the function of skin care, moisturizing, minimizing fat secretion, promotion cellular metabolism concurrently, the present invention is a kind of cosmetics for prophylactic treatment seat skin ulcer and skin whitening.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. an acne-removing liquid is characterized in that, by weight percentage, comprises following component:
A component: propylene glycol 3%～7%, HANSHENGJIAO 0.8%～2%, the first deionized water 55%～65%;
B component: two isethionic acid hexyl ethers 0.05%～0.1%, vitamin B6 0.2%～0.9%, the second deionized water 3%～7%;
C component: plant extraction liquid 15%～25%, azelaic acid derivant 1%～4%, Herba Dendranthematis indici dimension element 2%～5%, salicylic acid 0.2%～1%, Radix Ginseng extract 0.5%～2%, vitamin E 0.3%～1.0%, germall BP 0.1%～0.5%, lavandula angustifolia essence.
2. acne-removing liquid as claimed in claim 1, it is characterized in that: described plant extraction liquid is one or more in Flos Lonicerae, Aloe, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Semen Plantaginis, the Fructus Kochiae, Fructus Cnidii, Rhizoma Coptidis, Concha Margaritifera, Radix Curcumae and the Radix Stemonae.
3. the preparation method such as each described acne-removing liquid of claim 1-2 is characterized in that, may further comprise the steps:
1) described A component is heated to temperature T
1Be 85 ℃, enable simultaneously agitator and stir, treat its dissolve complete;
2) with described B component in temperature T
2Dissolving is stirred with described agitator when being 25 ℃, treats its dissolve complete;
3) use cooling water to stir the A component behind the dissolve complete in the described step 1 and be cooled to temperature T
3When being 40～50 ℃, add the B component behind the dissolve complete in the described step 2, stir while adding, after described B component adding is finished, start homogenizer emulsifying 5～15 minutes;
4) described C component is added in the mixture that obtains in the described step 3, stir while adding, treat that it dissolves fully, stir, be evacuated to liquid level still;
5) open the interlayer cooling water, be cooled to temperature T
4Described acne-removing liquid is namely made in 35～40 ℃ of dischargings.
4. the preparation method of acne-removing liquid as claimed in claim 3, it is characterized in that: described temperature T 3 is 40～45 ℃.
5. the preparation method of acne-removing liquid as claimed in claim 3, it is characterized in that: emulsifying is 10～15 minutes in the described step 3.
6. the preparation method of acne-removing liquid as claimed in claim 3, it is characterized in that: the mixing speed of described blender is 2800～3000 rev/mins.
7. the preparation method of acne-removing liquid as claimed in claim 3, it is characterized in that: described homogenizing speed is 1200～1400 rev/mins.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602657A (en) * | 2019-01-04 | 2019-04-12 | 石家庄珂蓝美容服务有限公司 | A kind of draft point acne liquid |
| CN111297743A (en) * | 2019-12-10 | 2020-06-19 | 北京旋光普利生物医药科技开发有限公司 | Preparation of acne-removing hydrosol (toning lotion) |
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|---|---|---|---|---|
| CN1356106A (en) * | 2000-12-08 | 2002-07-03 | 王宗宽 | Lotion for treating acne and its preparing process |
| CN101524317A (en) * | 2009-03-26 | 2009-09-09 | 宁波大学 | Skin-care cosmetic dispelling freckles and containing nonane diacid |
| CN102232913A (en) * | 2010-04-26 | 2011-11-09 | 王洪 | Medical mask for eliminating acnes |
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2012
- 2012-12-21 CN CN201210560595.7A patent/CN103006528B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356106A (en) * | 2000-12-08 | 2002-07-03 | 王宗宽 | Lotion for treating acne and its preparing process |
| CN101524317A (en) * | 2009-03-26 | 2009-09-09 | 宁波大学 | Skin-care cosmetic dispelling freckles and containing nonane diacid |
| CN102232913A (en) * | 2010-04-26 | 2011-11-09 | 王洪 | Medical mask for eliminating acnes |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602657A (en) * | 2019-01-04 | 2019-04-12 | 石家庄珂蓝美容服务有限公司 | A kind of draft point acne liquid |
| CN111297743A (en) * | 2019-12-10 | 2020-06-19 | 北京旋光普利生物医药科技开发有限公司 | Preparation of acne-removing hydrosol (toning lotion) |
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| CN103006528B (en) | 2015-02-25 |
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