CN102936298B - Extraction system of heparin sodium - Google Patents

Extraction system of heparin sodium Download PDF

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Publication number
CN102936298B
CN102936298B CN201210517700.9A CN201210517700A CN102936298B CN 102936298 B CN102936298 B CN 102936298B CN 201210517700 A CN201210517700 A CN 201210517700A CN 102936298 B CN102936298 B CN 102936298B
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unit
tank
desorption
pipeline
pump
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CN201210517700.9A
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CN102936298A (en
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张玉根
许春龙
王丽燕
韩国栋
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NANTONG TIANLONG ANIMAL BY-PRODUCTS Co Ltd
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NANTONG TIANLONG ANIMAL BY-PRODUCTS Co Ltd
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Abstract

The invention relates to an extraction system of heparin sodium, in particular to a fully-automatic unmanned automatic extraction system. The extraction system of heparin sodium, provided by the invention, changes the traditional heparin sodium processing method, realizes a fully-automatic processing technology, and actually realizes unmanned operation. By adopting electronic monitoring equipment, the system provided by the invention monitors and controls each process; and through the built-in calculation formula of an integrated control unit and the built-in proportioning scheme, the system realizes real-time monitoring and real-time operation so as to obtain higher accuracy and yield.

Description

The extraction system of heparin sodium
Technical field
The present invention relates to a kind of extraction system of heparin sodium, specially refer to a kind of full-automation, operatorless automatization extraction system.
Background technology
Heparin sodium (Heparin Sodium) heparin sodium is mucopolysaccharide sulfuric acid ester anticoagulant.Heparin sodium is the sodium salt of the CSSO3 extracted in the intestinal mucosa of pig or ox, belongs to mucopolysaccharide material.Recent study proof heparin sodium also has reducing blood lipid.Heparin sodium extraction process is of a great variety on the market at present, but the technique of majority's semi-automation, or the skill of total man's work, its production efficiency is low, and monitor data is inaccurate, causes the problems such as output capacity is low.
Summary of the invention
The invention provides a kind of extraction system of heparin sodium, it has changed the adding method of heparin sodium in the past, realizes full-automatic treatment process, really realizes unattended.
For completing foregoing invention object, the present invention is achieved in that a kind of extraction system of heparin sodium, it by the unit of preparing burden, resolving cell, absorbing unit, desorption unit, spill heavy unit and central control unit forms, described batching unit, resolving cell, absorbing unit, desorption unit and spill heavy unit and be connected by pipeline successively; Described central control unit is connected with other cell signal, it is characterized in that:
Described batching unit is to consist of two material-compound tanks, and two material-compound tanks connect material source by pipeline respectively; Described material-compound tank has heating function and built-in agitator, and Heating temperature, pH value and concentration are controlled by central control unit; Two described tank bodies are respectively equipped with discharge port by controlled valve and pipeline downlink connection, from controlled valve two pipelines out merge, are divided into two-way again, flow to resolving cell, and this pipeline are provided with under meter through force (forcing) pump pressurization by a pipeline;
Described resolving cell is by several, to decompose tank to form; Described each decomposed tank and is respectively equipped with opening for feed, discharge port, steam port; And opening for feed, discharge port and steam port are respectively equipped with controlled valve, built-in agitator, this controlled valve is controlled by central control unit; In described decomposition tank, be provided with temperature inductor, pressure inductor, pH value detector and concentration inductor block; The described outlet of respectively decomposing tank is connected on a pipeline, then separates two pipelines by a pipeline, connects respectively vacuum primingpump; Remerge a pipeline, deliver to absorbing unit;
Described absorbing unit is to consist of several adsorption tanks, and described adsorption tanks are respectively equipped with opening for feed, discharge port, clear water import, and built-in agitator; Described clear water import connects clear water pipe through controlled valve; Described discharge port picks out after the unification of material pipeline gathers and through impeller pump, connects resin trap by a pipeline; Before described opening for feed, connect controlled valve;
Described desorption unit is to consist of several desorption tanks, each described desorption tank is respectively equipped with opening for feed, discharge port, steam inlet, in described desorption tank, be provided with temperature inductor and agitator, described desorption tank group is provided with a bypass, bypass is provided with brine tank and salt solution pond for recovering, and the import of described brine tank is connected with clear water pipe by pump; The discharge port of described desorption tank is connected to salt solution pond for recovering after connecting, and salt solution pond for recovering connects continuously by managing with brine tank;
The described heavy unit that spills is by several, to spill heavy jar to form, and described each spilt heavy tank and be provided with opening for feed, discharge port.
Technique scheme is further limited, described central control unit is to consist of information process unit, information recording unit, command triggers device and PLC, and described information recording unit is divided into batching recording section, decomposes recording section, adsorbs recording section, desorption recording section, spills heavy recording section; Described command triggers device is triggered once each second, and the parameter being set according to inside is carried out respectively batching unit, resolving cell, absorbing unit, desorption unit, spilt heavy unit.PLC, for obtaining all data logging, utilizes interval to trigger, and strengthens control and monitoring, makes technique reach perfect.
Technique scheme is further limited, and described batching unit is provided with automatic liquid level detector and proportioning inductor block, and described automatic liquid level detector and proportioning inductor block are controlled by central control unit all.
Technique scheme is improved further, described PLC receives the different pieces of information from each tank, subdivision deposits respectively batching recording section in, decomposes recording section, adsorbs recording section, desorption recording section, spills heavy recording section, and each part is inserted different forms according to different type of different time periods again; According to data, every generation once changes just according to the formula calculating setting once described information process unit, thereby makes order triggering device triggering device trigger a corresponding charging of command execution, discharging, water inlet, admission.Whether described PLC receives the rotating speed of temperature from each tank body, concentration, agitator, flooding quantity, inlet amount, load, Open valve, the flow of valve, height of liquid level.By upper PLC receipts, connect different data and divide into groups to calculate respectively, do not interfere with each other, do not affect mutually, adopt the concurrent operator scheme of multithreading multi-channel information, make to be mutually connected closely, and do not interfere with each other.
Technique scheme is further limited, be equipped with flow gauge entering resolving cell, absorbing unit and spill on the main pipeline of heavy unit, and flow gauge can makes zero.
From resolving cell to absorbing unit, be provided with discharging pump group and force (forcing) pump group, described discharging pump group is to consist of two phases the discharging pump that connects, and described force (forcing) pump group is that two phases the pressurizing cenrrifugal pump that connects form, series winding before and after discharging pump group and force (forcing) pump group.This programme utilization pressurization, the means such as bypass reach the connection between each unit, have guaranteed connection on the one hand, and the connection for Unit two plays vital status on the other hand.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of batching unit.
Fig. 2 is the schematic diagram of resolving cell.
Fig. 3 is the schematic diagram of absorbing unit.
Fig. 4 is the schematic diagram of desorption unit.
Fig. 5 is the schematic diagram that spills heavy unit.
Fig. 6 is overall schematic.
Embodiment
As shown in the figure, a kind of extraction system of heparin sodium, it by the unit 1 of preparing burden, resolving cell 2, absorbing unit 3, desorption unit 4, spill heavy unit 5 and central control unit forms, described batching unit 1, resolving cell 2, absorbing unit 3, desorption unit 4 and spill heavy unit 5 and by pipeline, be connected successively; Described central control unit carries out signal control with other unit by PLC and is connected.
Described batching unit 1 is to consist of two material-compound tanks 11,12, and two material-compound tanks are integrated, steam inside heating; By pipeline, connect material source respectively; The number of charging and the inlet amount of each tank are controlled by central control unit, and described material-compound tank has heating function and built-in agitator, and Heating temperature, pH value and concentration are controlled by central control unit; Two described tank bodies are respectively equipped with discharge port and are connected with pipeline by controlled valve, from controlled valve two pipelines out, be merged into just shape materail tube 13 of a road, after be divided into again two-way, through force (forcing) pump 14 pressurization, by a pipeline, flow to resolving cell, and this pipeline is provided with under meter; Central control unit can be set inlet amount according to the amount that will make; Constantly control temperature and stirring velocity in tank.
As shown in the figure, resolving cell is by several, to decompose tank 21 to form, and the present embodiment is to take eight tanks as example; Described each decomposed tank 21 and is respectively equipped with decomposition opening for feed 22, decomposes discharge port 25, decomposes steam port 24, decomposes clear water import 23; And decompose opening for feed 22, decomposition discharge port 25 and decomposition steam port 24 and be respectively equipped with controlled valve, built-in agitator, this controlled valve is controlled by central control unit; Decompose charging and sent here by batching unit, by a mobile jib pipeline 26, Cheng Bage branch, is furnished with a controllable valve in each branch respectively, connects with the opening for feed that decomposes tank and is connected; Decomposing clear water pipe is also to be come in by a supervisor, is divided into Ba Ge branch, and each branch is also equipped with after controlled valve each tank body again and connects.Comprising the admission of steam, is also to design like this, and object is in order to control each tank body completely.Controlled valve is installed respectively by the same You Bage of discharge port branch, then imports a mobile jib pipeline 26.In described decomposition tank, be provided with temperature inductor, pressure inductor, pH value detector and concentration inductor block; The data that temperature inductor, pressure inductor, pH value detector and concentration inductor block obtain are all shown on the display screen of central control unit, very clear.Discharge port finally separates two pipelines by a pipeline, connects respectively vacuum primingpump 28; Remerge a pipeline, then be divided into two-way, then carry out Road agitator 29, finally merge and deliver to absorbing unit.Because tank body is very large, although quite abundant the stirring in tank, by excessively, to process in absorption Dan Yuan, tend to appear at the heavy pasture of material and adhere to the problems such as tube wall; Add therebetween the agitator of passing by one's way, allow intermediate material activity, one side can guarantee whether process interrupts decomposing therebetween, can not avoid on the one hand the appearance of the problems referred to above, reduce the maintenance of equipment.
Described absorbing unit 3 is to consist of several adsorption tanks 34, and the present embodiment is that eight tank bodies form, and each adsorption tanks is respectively equipped with adsorption tanks opening for feed 33, adsorption tanks discharge port 36, adsorption tanks clear water import 35, and built-in agitator; Before absorbing unit, I have also set up a swirling flow unit 31, it be by and the two groups of Turo pumps and the valve that connect form, the effect of Turo pump is to allow fluid rotation in pipe, the distance from Turo pump to adsorption tanks is quite short, is almost direct connection.This mode of revolving flow into tank is not have in conventional art; All along wall streamer habitually in the past; And adopt eddy flow to spray into tank here, allow output capacity than in the past, exceed 1 percentage point.Described adsorption tanks opening for feed, adsorption tanks discharge port and the import of adsorption tanks clear water are the same with decomposition tank, are all that by absorption mobile jib Guan32 branch out Qie Meigen branch adds controlled valve; Adsorption tanks discharge port picks out after the unification of material pipeline gathers and through impeller pump 37, connects resin trap 38 by a pipeline, finally resin is discharged, and material is delivered to desorption unit.
Desorption unit is to consist of several desorption tanks, this programme has adopted three tank bodies 41, each described desorption tank is respectively equipped with desorption opening for feed 42, desorption discharge port 47, desorption steam inlet 44 and desorption clear water import 43, the same with above-mentioned design, before entering tank, be equipped with controllable valve, in described desorption tank, be provided with temperature inductor and agitator, described desorption tank group is provided with a bypass, bypass is provided with brine tank 46 and salt solution pond for recovering 48, and the import of described brine tank is connected with clear water pipe by pump 45; The discharge port of described desorption tank is connected to salt solution pond for recovering after connecting, and salt solution pond for recovering 48 connects continuously by managing with brine tank; The described heavy unit 5 that spills is by several, to spill heavy tank 51 to form, and described each spilt heavy tank and be provided with opening for feed 52, discharge port.
This patent adopts electrons watch-dog, and each procedure is monitored and controlled, and by the built-in calculation formula at integrated control unit, in advance built-in mix proportion scheme, realizes monitoring in real time, true-time operation, thus more accurate output capacity is higher.

Claims (7)

1. the extraction system of a heparin sodium, it by the unit of preparing burden, resolving cell, absorbing unit, desorption unit, spill heavy unit and central control unit forms, described batching unit, resolving cell, absorbing unit, desorption unit and spill heavy unit and be connected by pipeline successively; Described central control unit is connected with other cell signal, it is characterized in that:
Described batching unit is to consist of two material-compound tanks, and two material-compound tanks connect material source by pipeline respectively; Described material-compound tank has heating function and built-in agitator, and Heating temperature, pH value and concentration are controlled by central control unit; Two described tank bodies are respectively equipped with material-compound tank discharge port by controlled valve and pipeline downlink connection, from controlled valve two pipelines out merge, are divided into two-way again, flow to resolving cell, and this pipeline are provided with under meter through force (forcing) pump pressurization by a pipeline;
Described resolving cell is by several, to decompose tank to form; Described each decomposed tank and is respectively equipped with decomposition opening for feed, decomposes discharge port, decomposes steam port; And decompose opening for feed, decomposition discharge port and decomposition steam port and be respectively equipped with controlled valve, built-in agitator, this controlled valve is controlled by central control unit; In described decomposition tank, be provided with temperature inductor, pressure inductor, pH value detector and concentration inductor block; The described outlet of respectively decomposing tank is connected on a pipeline, then separates two pipelines by a pipeline, connects respectively vacuum primingpump; Remerge a pipeline, deliver to absorbing unit;
Described absorbing unit is to consist of several adsorption tanks, and described adsorption tanks are respectively equipped with absorption opening for feed, absorption discharge port, the import of absorption clear water, and built-in agitator; Described absorption clear water import connects clear water pipe through controlled valve; Described absorption discharge port picks out after the unification of material pipeline gathers and through impeller pump, connects resin trap by a pipeline; Before described absorption opening for feed, connect controlled valve;
Described desorption unit is to consist of several desorption tanks, each described desorption tank is respectively equipped with desorption opening for feed, desorption discharge port, desorption steam inlet, in described desorption tank, be provided with temperature inductor and agitator, described desorption tank group is provided with a bypass, bypass is provided with brine tank and salt solution pond for recovering, and the import of described brine tank is connected with clear water pipe by pump; The discharge port of described desorption tank is connected to salt solution pond for recovering after connecting, and salt solution pond for recovering connects continuously by managing with brine tank;
Described to spill heavy unit be by several, to spill heavy jar to form, and described each spilt heavy tank and be provided with and spill heavy opening for feed, spill heavy discharge port;
Before absorbing unit, also set up a swirling flow unit, it be by and the two groups of Turo pumps and the valve that connect form, the effect of Turo pump is to allow fluid rotation in pipe, the distance from Turo pump to adsorption tanks is short, is equivalent to direct connection.
2. the extraction system of a kind of heparin sodium according to claim 1, it is characterized in that: described central control unit is to consist of information process unit, information recording unit, command triggers device and PLC, described information recording unit is divided into batching recording section, decomposes recording section, adsorbs recording section, desorption recording section, spills heavy recording section; Described command triggers device is triggered once each second, and the parameter being set according to inside is carried out respectively batching unit, resolving cell, absorbing unit, desorption unit, spilt heavy unit.
3. the extraction system of a kind of heparin sodium according to claim 1, is characterized in that: described batching unit is provided with automatic liquid level detector and proportioning inductor block, and described automatic liquid level detector and proportioning inductor block are controlled by central control unit all.
4. the extraction system of a kind of heparin sodium according to claim 2, it is characterized in that: described PLC receives the different pieces of information from each tank, subdivision deposits respectively batching recording section in, decomposes recording section, adsorbs recording section, desorption recording section, spills heavy recording section, and each part is inserted different forms according to different type of different time periods again; According to data, every generation once changes just according to the formula calculating setting once described information process unit, thereby makes order triggering device triggering device trigger a corresponding charging of command execution, discharging, water inlet, admission.
5. the extraction system of a kind of heparin sodium according to claim 4, it is characterized in that: described PLC receives the rotating speed of temperature from each tank body, concentration, agitator flooding quantity, inlet amount, load, whether Open valve, the flow of valve, height of liquid level.
6. the extraction system of a kind of heparin sodium according to claim 4, is characterized in that: be equipped with flow gauge entering resolving cell, absorbing unit and spill on the main pipeline of heavy unit, and flow gauge can make zero.
7. the extraction system of a kind of heparin sodium according to claim 4, it is characterized in that: from resolving cell to absorbing unit, be provided with discharging pump group and force (forcing) pump group, described discharging pump group is to consist of two phases the discharging pump that connects, described force (forcing) pump group is that two phases the pressurizing cenrrifugal pump that connects form, series winding before and after discharging pump group and force (forcing) pump group.
CN201210517700.9A 2012-12-06 2012-12-06 Extraction system of heparin sodium Active CN102936298B (en)

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Publication number Priority date Publication date Assignee Title
CN105732845A (en) * 2016-04-18 2016-07-06 江苏万力生物科技有限公司 Heparin sodium enzymolysis engineering control method
CN107057301B (en) * 2017-05-13 2019-04-19 广东圆融新材料有限公司 A kind of fire-retardant reinforced PBT composite material and preparation method thereof of excellent laser printing effect

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CN102516415A (en) * 2011-12-14 2012-06-27 南京金日轻工科技发展有限公司 Three-in-one tank for processing heparin

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CN2367609Y (en) * 1999-03-30 2000-03-08 晏道平 Liquid fluide adsorption and analytic apparatus for production of liquaemin
CN101851301A (en) * 2010-06-02 2010-10-06 喻延安 Method for extracting crude product of heparin sodium
CN201825901U (en) * 2010-10-27 2011-05-11 四川泓乾生物科技有限公司 Production device for heparin sodium medicine
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