CN102847170B - 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液 - Google Patents

用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液 Download PDF

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Publication number
CN102847170B
CN102847170B CN201210345209.2A CN201210345209A CN102847170B CN 102847170 B CN102847170 B CN 102847170B CN 201210345209 A CN201210345209 A CN 201210345209A CN 102847170 B CN102847170 B CN 102847170B
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Prior art keywords
nanoemulsion
component
perfluorocarbon
endocytosis
sirna
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Expired - Fee Related
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CN201210345209.2A
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English (en)
Chinese (zh)
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CN102847170A (zh
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S.施赖伯
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Ruhr Universitaet Bochum
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Ruhr Universitaet Bochum
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201210345209.2A 2008-05-19 2009-05-13 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液 Expired - Fee Related CN102847170B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08156434A EP2123256A1 (en) 2008-05-19 2008-05-19 Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer
EP081564346 2008-05-19
CN200980118149.7A CN102112109B (zh) 2008-05-19 2009-05-13 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液

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CN200980118149.7A Division CN102112109B (zh) 2008-05-19 2009-05-13 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液

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CN102847170A CN102847170A (zh) 2013-01-02
CN102847170B true CN102847170B (zh) 2016-03-16

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CN200980118149.7A Expired - Fee Related CN102112109B (zh) 2008-05-19 2009-05-13 用于基因传递的具有增强内吞作用的表面的全氟化碳纳米乳液

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Country Status (14)

Country Link
US (1) US9616131B2 (https=)
EP (3) EP2123256A1 (https=)
JP (1) JP5546534B2 (https=)
CN (2) CN102847170B (https=)
AU (1) AU2009249812B2 (https=)
CA (1) CA2725513C (https=)
DK (2) DK2510921T3 (https=)
ES (2) ES2391375T3 (https=)
HU (1) HUE035320T2 (https=)
IL (1) IL209205A (https=)
NZ (1) NZ589417A (https=)
PL (2) PL2510921T3 (https=)
WO (1) WO2009141257A1 (https=)
ZA (1) ZA201008274B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123256A1 (en) 2008-05-19 2009-11-25 Ruhr-Universität Bochum Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer
US20140065223A1 (en) * 2011-03-31 2014-03-06 Jeanette Libera-Koerner Perfluorinated compounds for the non-viral transfer of nucleic acids
CN103263695B (zh) * 2013-05-17 2014-10-29 中国人民解放军第四军医大学 全氟三乙胺乳液与种子细胞复合的神经导管制备方法
CN103251980B (zh) * 2013-05-17 2014-07-02 中国人民解放军第四军医大学 全氟三丁胺与纤维蛋白水凝胶复合的神经导管制备方法
EP2853595A1 (en) 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules
CN110177575B (zh) * 2016-12-01 2024-02-13 国立大学法人埼玉大学 药物递送系统用胞吞作用增强剂
WO2025080939A1 (en) 2023-10-13 2025-04-17 Ultragenyx Pharmaceutical, Inc. Compositions and methods for treating conditions associated with cartilage oligomeric matrix protein (comp) mutations
WO2025128853A2 (en) 2023-12-13 2025-06-19 Ultragenyx Pharmaceutical Inc. Compositions and methods for treating conditions associated with ube3a overexpression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195981A (zh) * 1995-06-07 1998-10-14 联合药品公司 药物输送用的反相碳氟化合物乳液组合物
CN1454084A (zh) * 2000-07-20 2003-11-05 佩尔夫托拉科研生产公众股份公司 一种用于医药目的的全氟有机化合物的乳液、其制备方法和利用其治疗和预防疾病的方法

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JPS6050578B2 (ja) 1981-12-25 1985-11-09 日本スチレンペ−パ−株式会社 合成樹脂発泡体の製造法
FR2720943B1 (fr) 1994-06-09 1996-08-23 Applic Transferts Technolo Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples.
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
JP2001002592A (ja) 1999-06-18 2001-01-09 Dai Ichi Seiyaku Co Ltd 遺伝子導入用組成物
KR100872884B1 (ko) 2000-03-24 2008-12-10 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
US20020155084A1 (en) * 2000-06-02 2002-10-24 The Regents Of The University Of The Michigan Nanoemulsion formulations
CA2452471C (en) 2001-07-10 2010-06-29 Michael N. Davidson Enhancement of transfection of dna into the liver
US20040115159A1 (en) 2002-03-29 2004-06-17 Tadlock Charles C Novel nanoemulsions
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
US20070184076A1 (en) 2006-02-07 2007-08-09 Unger Evan C Liquid-filled nanodroplets for anti-cancer therapy
EP1844772A1 (en) 2006-04-06 2007-10-17 Polyplus-Transfection SA Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications
EP2123256A1 (en) 2008-05-19 2009-11-25 Ruhr-Universität Bochum Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195981A (zh) * 1995-06-07 1998-10-14 联合药品公司 药物输送用的反相碳氟化合物乳液组合物
CN1454084A (zh) * 2000-07-20 2003-11-05 佩尔夫托拉科研生产公众股份公司 一种用于医药目的的全氟有机化合物的乳液、其制备方法和利用其治疗和预防疾病的方法

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
CN102847170A (zh) 2013-01-02
CN102112109B (zh) 2016-10-12
EP2285349B1 (en) 2012-07-11
PL2285349T3 (pl) 2012-12-31
HK1179533A1 (zh) 2013-10-04
PL2510921T3 (pl) 2017-12-29
DK2285349T3 (da) 2012-10-22
EP2510921A1 (en) 2012-10-17
HK1159479A1 (zh) 2012-08-03
IL209205A (en) 2015-08-31
ZA201008274B (en) 2012-02-29
CA2725513C (en) 2013-07-02
EP2510921B1 (en) 2017-07-12
WO2009141257A1 (en) 2009-11-26
ES2391375T3 (es) 2012-11-23
CA2725513A1 (en) 2009-11-26
JP2011520936A (ja) 2011-07-21
NZ589417A (en) 2012-03-30
AU2009249812A1 (en) 2009-11-26
IL209205A0 (en) 2011-01-31
EP2285349A1 (en) 2011-02-23
AU2009249812B2 (en) 2013-08-22
HUE035320T2 (en) 2018-05-02
US20110091561A1 (en) 2011-04-21
DK2510921T3 (en) 2017-10-23
CN102112109A (zh) 2011-06-29
US9616131B2 (en) 2017-04-11
JP5546534B2 (ja) 2014-07-09
EP2123256A1 (en) 2009-11-25
ES2642316T3 (es) 2017-11-16

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