CN102805792B - Ointment for treating hemorrhoids and preparation method thereof - Google Patents
Ointment for treating hemorrhoids and preparation method thereof Download PDFInfo
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- CN102805792B CN102805792B CN201210307503.4A CN201210307503A CN102805792B CN 102805792 B CN102805792 B CN 102805792B CN 201210307503 A CN201210307503 A CN 201210307503A CN 102805792 B CN102805792 B CN 102805792B
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Abstract
The invention discloses an ointment for treating hemorrhoids and a preparation method thereof. The ointment is prepared from the following Chinese medicines in part by weight: 30 parts of elephant leather, 30 parts of coptis root, 30 parts of dragon bone, 15 parts of myrrh, 15 parts of frankincense, 15 parts of cuttlebone, 10 parts of dried alum, 3 parts of dragon's blood and 0.3 part of borneol; and the preparation method of the ointment comprises the following steps of: smashing the Chinese medicines into powder, adding sesame oil and vaseline into the powder to obtain the ointment, smearing the ointment on a spun yarn cloth strip, putting the smeared spun yarn cloth strip into an aluminum box with holes, steaming at high temperature and high pressure for half an hour, cooling the ointment, and applying the ointment to a wounded part. The ointment can heal wound and promote tissue regeneration, clear heat and remove toxicity, diminish swelling and relieve pain, and relieve itching and stop bleeding, and is applicable to the treatment of non-healing wound surfaces after a hemorrhoid operation is performed, and early treatment of internal hemorrhoids, external hemorrhoids and mixed hemorrhoids; the ointment has a good curative effect, and can quickly heal the wound surfaces after the hemorrhoid operation is performed; and according to pharmacodynamic analysis, the cure rate is 21.83 percent, the obvious effective rate is 50.7 percent, the effective rate is 22.53 percent, the ineffective rate is 4.92 percent, and the total effective rate is 95.07 percent.
Description
Technical field
The present invention relates to a kind of ointment for the treatment of hemorrhoid and preparation method thereof, be used for the treatment of the disunion of a specified duration of hemorrhoid postoperative wound surface, internal hemorrhoid, external hemorrhoid, the early stage treatment of mixed hemorrhoid.
Background technology
Application number CN01114069.0, publication number are the patent that CN1327833A, denomination of invention are " external-applied ointments for the treatment of hemorrhoid ", a kind of external-applied ointment for the treatment of hemorrhoid is disclosed, by Herba Taraxaci, Flos Carthami, Talcum, Olibanum, Radix Et Rhizoma Rhei, Myrrha (processed), eupolyphage sece steleophaga, Sanguis Draxonis, Radix Notoginseng, Borneolum Syntheticum, formed, by Chinese medicine processing procedure, make external-applied ointment.Its principal claim is: " 1, a kind of external-applied ointment for the treatment of hemorrhoid, it is characterized in that the ointment of being made by ratio of weight and the number of copies by following Chinese herbal medicine: Herba Taraxaci 4～8, Flos Carthami 4～10, Talcum 1～4, Olibanum 4～8, Radix Et Rhizoma Rhei 2～5, Myrrha (processed) 5～9, eupolyphage sece steleophaga 1～3, Sanguis Draxonis 1～3, Radix Notoginseng 1～3, Borneolum Syntheticum 1～3.”
Application number is that CN03112526.3, publication number are the patent that CN1470265 A, denomination of invention are " a kind of Chinese medicinal ointment for the treatment of hemorrhoids disease ", discloses a kind of Chinese medicinal ointment for the treatment of hemorrhoids disease.Sending bright technical scheme elsewhere is: according to 9-12 gram of the weight portion Radix Angelicae Dahuricae, Cortex Phellodendri 9-12 gram, Radix Arnebiae (Radix Lithospermi) 9-12 gram, Flos Carthami 9-12 at, Borneolum Syntheticum 1-3 gram, Olibanum 6-9 gram, Myrrha 6-9 gram.First " Baizhi, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Flos Carthami decocting are got to liquid, with Borneolum Syntheticum, Olibanum, Myrrha smalls with become ointment.Its principal claim is: " 1, a kind of Chinese medicinal ointment for the treatment of hemorrhoids disease, it is characterized in that the weight portion formula of this ointment is: 9～12 grams of the Radixs Angelicae Dahuricae, 9～12 grams of Cortex Phellodendris, 9～12 grams of Radix Arnebiae (Radix Lithospermi)s, Flos Carthami 9～12.”
Application number is that CN200910179234.6, publication number are CN101700318A, the denomination of invention patent that is " a kind of ointment for the treatment of hemorrhoid and preparation method thereof ", disclose a kind of ointment for the treatment of hemorrhoid and preparation method thereof, it comprises that the component of following weight parts is: 5～7 grams, Cinnabaris, 6～8 grams of succinums, 5～8 grams of Os Draconis, 6～9 grams of Borneolum Syntheticums, 6～8 grams of Hydrargyri Oxydum Rubrum, 9～12 grams, pigment, 25～45 grams of Camellia oil.Its principal claim is: " a kind of ointment for the treatment of hemorrhoid, is characterized in that it comprises following component: 5～7 grams, Cinnabaris, 6～8 grams of succinums, 5～8 grams of Os Draconis, 6～9 grams of Borneolum Syntheticums, 6～8 grams of Hydrargyri Oxydum Rubrum, 9～12 grams, pigment, 25～45 grams of Camellia oil.”
Summary of the invention
The object of this invention is to provide ointment of the treatment hemorrhoid that a kind of curative effect is high, treatment hemorrhoid healing postoperative wound surface is fast and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
An ointment for the treatment of hemorrhoid, is characterized in that: the raw material of Chinese medicine by lower weight portion is prepared from by the following method: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
A preparation method for the ointment of hemorrhoid, is characterized in that: the raw material of Chinese medicine by lower weight portion is prepared by the following method: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
Expelling pus and promoting granulation of the present invention, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antipruritic, hemostasis.Be used for the treatment of the disunion of a specified duration of hemorrhoid postoperative wound surface, internal hemorrhoid, external hemorrhoid, the early stage treatment of mixed hemorrhoid.Curative effect of the present invention is high, treatment hemorrhoid healing postoperative wound surface is fast, through pharmacodynamic analysis, and cure rate 21.83%%, obvious effective rate 50.7%, effective percentage 22.53%, inefficiency 4.92% total effective rate 95.07%.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described:
A kind of ointment for the treatment of hemorrhoid of the present invention, is prepared from by the following method by the raw material of Chinese medicine of lower weight portion: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
A preparation method for the ointment of hemorrhoid, is characterized in that: the raw material of Chinese medicine by lower weight portion is prepared by the following method: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
Embodiment
The medicine material prescription (weight) of the ointment (hemorrhoid heal cream) for the treatment of hemorrhoid:
30 grams of Corium elephatiss, 30 grams of Rhizoma Coptidis, 30 grams of Os Draconis, 15 grams of Myrrhas, 15 grams of Olibanums, 15 grams of Endoconcha Sepiaes, 10 grams of dried Alumens, 3 grams of Sanguis Draxonis, 0.3 gram of Borneolum Syntheticum
Manufacture method: upper prescription grinds superfine end altogether, adds Oleum Sesami, vaseline furnishing ointment, and anoint, on spun yarn cloth, enters in aluminum box with holes, High Temperature High Pressure is steamed half an hour, the affected part of can applying ointment or plaster after cooling.
Using method: external, the affected part of applying ointment or plaster, once a day, 7th is a course for the treatment of.
Effect: expelling pus and promoting granulation, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antipruritic, hemostasis.Be used for the treatment of the disunion of a specified duration of hemorrhoid postoperative wound surface, internal hemorrhoid, external hemorrhoid, the early stage treatment of mixed hemorrhoid.
Therapeutic evaluation:
1, criterion of therapeutical effect is drafted and clinical symptoms according to national anorectal academic conference formulation standard in 1975, sign comprehensive therapeutic effect standards of grading are in order to make clinical efficacy judgement more accurate, in the above-mentioned standard of reference, cardinal symptom is quantized according to light and heavy degree, evaluation score value, curative effect is added up, judged to the last score value according to treatment front and back, and concrete standards of grading are in Table 1.
Table 1 clinical symptoms sign comprehensive observing standards of grading (dividing)
Recovery from illness: 40 minutes; Effective: 38～36 minutes, or score value is treated front increase more than 10 minutes or 10 minutes; Effective: 35 ~ 32 minutes, or score value is treated front increase more than 6 minutes or 6 minutes; Invalid: treatment front and back score value is without significant change, or score value increases below 3 minutes.Every routine total points is up to 40 minutes, represents that symptom and sign all disappears, and symptom is heavier, and score value is lower; When clinical symptoms, the judgement of sign comprehensive therapeutic effect, using score value as foundation.
2, therapeutic outcome (in Table 2).
Table 2 group total effects comparative example (%)
Clinical symptoms, sign are improved situation:
Before and after treatment, analyze relatively and show: treatment group is variant aspect hemostasis, pain relieving, elimination hemorrhoid edema, wound repairing, and statistical analysis treatment group is obviously better than matched group, treatment group and matched group comparison, P<0.05, difference significance.
Toxicity:
Treatment group 142 examples are done routine blood test, routine urinalysis, electrocardiogram, Chest X-rays, hepatic and renal function inspection before and after the medication, and result has no abnormal changes, and do not find that anal skin itches, flushing, the obvious adverse reaction such as pain.
Medicine and prescription analysis:
Corium elephatis, property is sweet salty, and taste temperature, cures mainly traumatic hemorrhage, and all wounds, ulcer do not close up for a long time.The effect with granulation promoting skin, nourishing blood and promoting blood circulation.Corium elephatis is joined the Endoconcha Sepiae sore of invigorating blood circulation; Join Olibanum energy promoting blood circulation and stopping pain, detumescence blood circulation promoting and blood stasis dispelling.Its chemical composition is mainly colloid albumen, still has carbohydrate and inorganic salt etc.Related Component has rapidly obvious antiinflammatory and promotes the effect of the healing of ulcer.
Rhizoma Coptidis, property is bitter, and taste is cold, has the effect of heat clearing and damp drying, eliminating fire and detoxication, the kind carbuncle furunculosis for the treatment of.In the just > > of < < book on Chinese herbal medicine, have " Rhizoma Coptidis large bitter Great Cold, bitter dampness, cold prevailing over heat; can all wet fire of having a surplus of drop-down; ... the cards such as anal fistula metrorrhagia and leukorrhagia, and carbuncle and ulcer macule erysipelas, and all rely on for support in this ".Its chemical composition master, containing multiple alkaloids such as berberine (berberine), has stronger antibiotic, antiulcer action.
Os Draconis, property is sweet, puckery is flat, and external has the effect of removing dampness, sore, granulation promoting, can control skin infection and burst and not hold back for a long time, normal and dried Alumen compatibility.< < Compendium of Materia Medica > > calls it the effect of " removing dampness gas, proctoptosis, promoting tissue regeneration and ulcer healing "; In < < Bencao Congxin > >, also there are " Os Draconis, sweet puckery flat ... sore " to record.Its chemical composition is mainly containing calcium carbonate, and calcium phosphate, can promote blood coagulation, reduces Vascular Permeability, and external clinically can be treated mixed hemorrhoids, mixed hemorrhoid.
Myrrha, acrid in the mouth, hardship, property is flat, has the effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, and normal and Olibanum mutual reinforcement between is use, the stagnant pain of the treatment traumatic injury stasis of blood, ulcer sore pain, skin infection does not close up after bursting and the stagnant pain card of all stasis of bloods for a long time.In < < Records of Tradition Chinese and Western Medicine in Combination > >, record " Olibanum, Myrrha, two medicines use ... external be powder to apply skin infection, can removing toxic substances and promoting subsidence of swelling, granulation promoting pain relieving ".Its chemical composition, containing compositions such as poponax resin, volatile oil, natural gum, has the effect of Antifungi, promoting blood circulation and stopping pain, detumescence and promoting granulation.
Olibanum, acrid in the mouth, hardship, warm in nature, there is the effect of blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.Because it can eliminating stasis to stop pain, the eliminating carbuncle of invigorating blood circulation again, putrefaction-removing granulation-promoting, is external wounds key medicine.For skin infection diabrosis, do not close up for a long time, often join Myrrha and grind into powder outer in order to promoting tissue regeneration and ulcer healing.Its chemical composition contains resin, natural gum and volatile oil, has the effect of analgesia, antiinflammatory, leukocyte increasing, and can accelerate inflammation and ooze out excretion, promotes the effects such as wound healing.
Endoconcha Sepiae, salty in the mouth, puckery, slightly warm in nature, has the effect of pain relieving, removing dampness sore.For ulcer being unable to heal, many pus, disunion person of a specified duration, can join the medicines such as dried Alumen, Borneolum Syntheticum and grind to the powder altogether, spread deposited affected part.Its chemical composition, mainly containing calcium carbonate, conchiolin, phlegmatic temperament, also containing various trace elements such as sodium, strontium, magnesium, ferrum, has antiulcer, promotes ulcer surface Healing.
Dried Alumen, is dehydration Alumen, sour in the mouth, puckery, and cold in nature, external has the merit of dampness removing to stop itchin, the kind wet rotten or pruritus of skin ulcer face, hemorrhoid, the proctoptosis etc. controlled.Its chemical composition sulfur acid aluminum potassium, because it has powerful solidifying protein effect, has the effects such as antiinflammatory, hemostasis, broad-spectrum antiseptic, promotion ulcer healing.The clinical treatment that has been applied to the diseases such as hemorrhoid, decubital ulcer, burn and scald.
Sanguis Draxonis, sweet in the mouth, salty, property is flat, has the effect of the analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, expelling pus and promoting granulation.Alone clinically, or the external such as compatibility Olibanum, Myrrha, there is the merit of expelling pus and promoting granulation, availablely control the card that skin infection is burst and do not held back for a long time.Its chemical composition is containing dracorhodin, dracorubin, demethyl dracorhodin, demethyl dracorubin and flavonol, chalcone derivative, resinic acid etc., can obviously reduce packed cell volume, shorten blood plasma in the calcification time, anticoagulant, prevent thrombosis, antiinflammatory, and staphylococcus aureus, Staphylococcus albus and multiple pathomycete are had to inhibitory action in various degree.Can be used for treating acute external hemorrhoid, chronic colitis.
Borneolum Syntheticum, acrid in the mouth, hardship, cold nature, because of its merit with clearing away heat to alleviate pain, erosion prevention and muscle growing, is used for skin infection and swells and ache, the sore being festered and unhealed, burn due to hot liquid or fire, many and Corium elephatis, Sanguis Draxonis, Olibanum are equal to use, treat above-mentioned illness.The bun of < < medical center wants > > to have the record of " Borneolum Syntheticum is controlled ... parasite killing, hemorrhoid ... granulation promoting pain relieving ".Its chemical composition is containing dextro Borneolum Syntheticum, again containing sesquiterpenes such as Humuleno, beta-elemene, caryophyllene, and the triterpenoid such as oleanolic acid, alphitolic acid, asiatic acid, Borneolum Syntheticum are aromatic, erythrodiol, there is anoxia enduring, calmness, pain relieving, the effect such as anticorrosion, antibacterial, multiple surgical infection inflammation is treated in external preparation external application (painting), as hemorrhoid, furuncle and phyma etc.
Comprehensive full side forms, and Corium elephatis, Rhizoma Coptidis, Os Draconis, Myrrha, Olibanum, Endoconcha Sepiae, dried Alumen, Sanguis Draxonis, Borneolum Syntheticum are combined as loose, and vaseline, Oleum Sesami are adjusted cream, plays altogether the effect of expelling pus and promoting granulation, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antipruritic, hemostasis.Clinically be used for the treatment of the disunion of a specified duration of hemorrhoid postoperative wound surface, the early stage treatment of mixed hemorrhoids.
Claims (2)
1. an ointment for the treatment of hemorrhoid, is characterized in that: the raw material of Chinese medicine by lower weight portion is prepared from by the following method: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae 15; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
2. a preparation method for the treatment of the ointment of hemorrhoid, is characterized in that: the raw material of Chinese medicine by lower weight portion is prepared by the following method: Corium elephatis 30; Rhizoma Coptidis 30; Os Draconis 30; Myrrha 15; Olibanum 15; Endoconcha Sepiae 15; Dried Alumen 10; Sanguis Draxonis 3; Borneolum Syntheticum 0.3; By the common pulverization of above-mentioned raw material of Chinese medicine, add Oleum Sesami, vaseline furnishing ointment, anoint, on spun yarn cloth, enters in aluminum box with holes, and High Temperature High Pressure is steamed half an hour, can become after cooling.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383274A (en) * | 2014-08-19 | 2015-03-04 | 牛振侠 | Traditional Chinese medicine composition controlling hemorrhoid postoperation infection |
| CN104435421A (en) * | 2014-11-12 | 2015-03-25 | 解金枝 | Care solution for nursing after hemorrhoids resection |
| CN105535647A (en) * | 2016-01-29 | 2016-05-04 | 林鸿 | Traditional Chinese medicine preparation for treating haemorrhoids of anorectal section and preparation method of traditional Chinese medicine preparation |
| CN105796696A (en) * | 2016-04-20 | 2016-07-27 | 周小龙 | Traditional Chinese medicine composition for fuming and washing mixed hemorrhoid |
| CN106075000A (en) * | 2016-08-02 | 2016-11-09 | 于梯 | A kind of Chinese medicine ointment for treating hemorrhoid and preparation method thereof |
| CN111568932B (en) * | 2020-06-04 | 2022-11-25 | 江苏海洋大学 | External pain-relieving and bleeding-stopping pharmaceutical composition and preparation method and application thereof |
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Non-Patent Citations (1)
| Title |
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| 张方胜编.生肌珍珠散.《中华传世医方下》.科学技术出版社,1999,960页. * |
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