CN102772271A - Self-fixing tissue patch - Google Patents
Self-fixing tissue patch Download PDFInfo
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- CN102772271A CN102772271A CN2012102383998A CN201210238399A CN102772271A CN 102772271 A CN102772271 A CN 102772271A CN 2012102383998 A CN2012102383998 A CN 2012102383998A CN 201210238399 A CN201210238399 A CN 201210238399A CN 102772271 A CN102772271 A CN 102772271A
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- polylactic acid
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- sticking patch
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Abstract
The invention relates to a self-fixing tissue patch which comprises a net face layer of a polypropylene material and a hook face layer of a degradable material, which is fixed at the lower surface of the net face layer of the polypropylene material. The self-fixing tissue patch disclosed by the invention is a true tension-free tissue patch. A polypropylene net face at an upper layer is used for repairing a defective or weak area, while a degradable hook face has the functions of positioning and preventing the patch from sliding. During the surgical operation, the self-fixing tissue patch can be fully expanded and is free from sewing and fixing. The surgical time is saved, and the ailment of a patient is relieved.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, in particular, the present invention relates to a kind of repair clinically inguinal hernia from the fixing organization sticking patch.
Background technology
Hernia is meant that internal organs have left original position, through weak spot or damaged, another position of hole entering of human body.The position that hernia the most often takes place is an abdominal part.Congenital or the posteriority that the interior internal organs of abdomen pass through stomach wall is damaged or weak area is outstanding to body surface, forms a lump in the part, is called abdominal external hernia.Interior internal organs of abdomen or nethike embrane leave original position through the normal or unusual duct of intraperitoneal, crack and promptly constitute internal abdominal hernia, can not be inspection finding, for example hernia of foramen of Winslow, diaphragmatocele etc.Abdominal external hernia is seen far beyond internal abdominal hernia more.Abdominal external hernia is one of modal disease of abdominal surgery, and is often with outstanding region of anatomy name, wherein the highest with the inguinal hernia incidence rate, accounts for more than 90%.Abdominal external hernia is a kind of multiple disease, all possibly take place to all old age brackets the child, and the elderly men sick group of people at high risk that is this.The cause of disease of abdominal external hernia increases relevant with stomach wall weakness and intra-abdominal pressure.The stomach wall weakness generally is geneogenous, also possibly caused by acquired disposition, like old, amyotrophy etc.The common situation that intra-abdominal pressure increases has chronic cough, constipation, dysuria and child cry etc.Though abdominal external hernia is not a fatal disease, its can bring very big misery to patient, have a strong impact on quality of life, and multiple complications can be arranged, but threat to life when serious.
At present, abdominal external hernia treatment goldstandard is a row " tension-free hernioplasty ".Promptly with operating mode, the patching material that will have given shape or structure is implanted stomach wall, through stimulating the body a large amount of fibrosis tissue of hypertrophy on patching material fast, repairs and strengthens damaged tissue, finally reaches the purpose of effecting a radical cure abdominal external hernia.
It is current application tension-free hernia material the most widely that polypropylene is implanted net.It is a kind of netted fabric of polypropylene monofilament of implant into body forever, adopts through compiling the technology braiding and processing through series of formed.The advantage of polypropylene sticking patch: stimulate the proliferation of fibrous tissue effect obvious; Ability is infected; Higher tensile strength is arranged; Price is relatively cheap.In in the past 60 years, polypropylene mesh produces tremendous influence to surgical field, and life is able to prolong countless patients because it has been arranged; Many surgery knotty problems solve because of its application; It has been proved to be the most popular implant of current surgery, and however, also there are some problems in polypropylene net in application: the surface ratio of net sheet is more coarse; When being used for stomach wall holostrome defect repairing, with the internal organs adhesion; When carrying out big abdominal defect repairing, the cicatrix contraction in later stage can cause the distortion of net sheet, and its irregular surface possibly stimulate and damage surrounding tissue, causes and infects and the formation of skin sinus tract.
The material of sticking patch requires more lightweight at present, and under the prerequisite of the enough tension stress intensity of maintenance, light more sticking patch has more comfortable patient's sensation and better compliance; The mesh of polypropylene mesh require enough greatly with the chance that reduces to infect with better compliance is provided, these 2 mainly is to make foreign body sensation littler, the person in charge feels more comfortable.The research of absorbable material is important developing direction, and every intravital material of people of putting into so long as not requiring the permanent support thing, should be that absorbable material is processed.Absorbable hernia patching material mainly contain polyglycolic acid (polyglycolic acid (Dexon)), polylactic-co-glycolic acid (polyglactin (Vicryl)) but two kinds of absorption mesh sheets in clinical use, its complete soak time is 3 months.But in practical application, it is found that, evoke enough proliferations of fibrous tissue, often form abdominal hernia once more after the absorption at the repairing position because Dexon and Vicryl can not sting.Therefore, it is still immature that these two kinds of materials are used for the abdominal-wall defect repairing.
U.S. Metabolix was a raw material with reproducible starch, fiber in 1992; Adopt plurality of enzymes such as the gene engineering technique PHA that the biosynthesis PHA is required, P34HB to be implemented among the E.Coli; Reproducible carbon source is converted into gathers the hydroxyl macromolecular compound in bacterial body; Extract the PHA of different component with wet method, success develop the 4th generation PHA biological plastics-poly 3-hydroxy butyrate 4 hydroxybutyric acid ester.Tepha company has carried out special later stage applied research to this material, and in February, 2007, the operation suture thread of being processed by P34HB has obtained the approval of U.S. FDA.But poor heat stability, the hot strength of P34HB material are low, processability is poor, if not in addition modification can not use as hernia patch.
Polylactic acid has excellent physical and mechanical properties, and is the same with other all macromolecules, and (Poly Lactic Acid, performance PLA) has very big influence to polylactic acid for molecular weight size, distribution, crystallinity.Because there is optical isomer in polylactic acid, also be key factor to the mechanical property influence.Another characteristic of polylactic acid-based material is to process with multiple mode, as extrude, spinning, biaxial stretch-formed, molecular orientation not only can significantly increase mechanical strength in the course of processing, makes degradation time slack-off simultaneously.Though polylactic acid has advantages such as good biocompatibility, biodegradability, it has limited its practical application having following defective in nature: 1) a large amount of ester bonds is arranged in the polylactic acid, be lyophobic dust, reduced its biocompatibility; 2) degradation cycle is difficult to control; Simultaneously, in practical application, also have some special functional requirements.This all impels people that the modification of poly-lactic acid material is launched deep research.
Summary of the invention
In order to solve the above-mentioned technical problem that exists in the prior art; The object of the present invention is to provide a kind ofly,, reduce foreign body implantation amount and avoid sutured through composite braided from the fixing organization sticking patch; Not only can the Efficient software patching defect, and significantly reduced patient's pain.
Realize the foregoing invention purpose in order to solve the problems of the technologies described above, the present invention adopts following technical scheme:
A kind of from the fixing organization sticking patch, it comprises wire side layer and the degradation material hook surface layer that is fixed on said wire side layer lower surface.
Wherein, said wire side layer is a polypropylene material wire side layer.
Wherein, described degradation material is for gathering the blend of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer (P34HB) and polylactic acid (PLA), and the number-average molecular weight of wherein said polylactic acid is 9-15 * 10
4, the content of polylactic acid is 75-90wt% in blend; Said gathering, the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer was 25-40 * 10
4, the content in blend is 10-25wt%, the molar content of wherein in copolymer, gathering the 4 hydroxybutyric acid ester is 40%.
Wherein, the number-average molecular weight of described polylactic acid is 9-12 * 10
4, the content of polylactic acid is 75-85wt% in blend, said gathering the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer be 25-35 * 10
4, the content in blend is 15-25wt%.
Wherein, the number-average molecular weight of described polylactic acid is 10 * 10
4, the content of polylactic acid is 80wt% in blend, said gathering the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer be 30 * 10
4, the content in blend is 20wt%.
Wherein, describedly be fixed as bonding, welding or sew up.
Wherein, said polypropylene material wire side layer is shaped as circle, ellipse or Long Circle.
Wherein, said hook surface layer comprises the ditch composition that has agnail in a large number, and little hook direction is consistent, length is identical.
Compared with prior art, the present invention has the following advantages:
(1) of the present invention is a kind of real no tension force tissue patch from the fixing organization sticking patch, and the polypropylene wire side on upper strata is used to repair damaged or weak area, and degradable hook mask has the location and prevent the function that sticking patch slides.In operation technique, fixedly hernia patch can fully launch certainly, avoids sutured, has saved operating time, has alleviated patient's slight illness.
(2) the present invention uses through gathering (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer number-average molecular weight is 9-15 * 10
4Polylactic acid carry out intermingling material that blending and modifying obtains as the hook surface layer.When the number-average molecular weight of polylactic acid is lower than 9 * 10
4The time, during as the hook surface layer, the intensity of polylactic acid is often not enough, and is higher than 15 * 10 when the number-average molecular weight of polylactic acid
4The time, the ester bond quantity in the polylactic acid is big, and biocompatibility reduces, and is not suitable for as the hook surface layer that can degrade; But research finds simultaneously that also number-average molecular weight is 9-15 * 10
4The polylactic acid degradation cycle be difficult to control, evoke enough proliferations of fibrous tissue nor can sting.Inventor of the present invention for this reason is devoted to polylactic acid is carried out modification, and the inventor finds when utilizing number-average molecular weight to be 25-40 * 10
4Plasticity P34HB when carrying out blending and modifying; When the content of P34HB in 10-25wt%, can dissolve each other fully that it is good to obtain pliability, the intermingling material that non-deformability is stronger; And the research modification intermingling material also finding when the content that gathers the 4 hydroxybutyric acid ester in the copolymer is 40%, to obtain good mechanical properties not only; Zoopery shows, and is can also the control degradation cycle relatively stable through above-mentioned P34HB blending and modifying, continues 3-6 month from beginning degraded usually to being absorbed fully; And good biocompatibility, the abdomen thigh hook after the repairing has compliance preferably.
Description of drawings
Fig. 1: embodiment 1 is described from fixing organization sticking patch structural representation.
The specific embodiment
Utilization gathers (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer (P34HB) polylactic acid (PLA) is carried out blending and modifying; P34HB is mixed with PLA; Adopt twin-screw mixer machine blend basis pelletize; Hot-forming under 160 ℃, with CMT4000 system controlled by computer electronics universal testing machine material sample is carried out mechanical analysis then, measure hot strength (test strength), elongation at break (elongation at break) and the elastic modelling quantity (modulus ofelasticity) of material.Determine behind the dumb-bell shape batten with the thickness and the width of miking batten, initial gauge length 25mm clips the dumb-bell shape batten, and displacement begins the load-deformation curve with the speed record material of 5mm/min draw speed after returning zero.Experimental result shows: in blend, when the content of P34HB was 10-25wt%, hot strength was 20-35MPa, and elongation at break is greater than 130%; With differential scanning calorimetry DSC the blending and modifying measurement is carried out thermoanalytical the time; We find when the content of P34HB is 10-25wt%, to have only a Tg; Thereby be illustrated under the selected number-average molecular weight condition; P34HB and PLA are compatible fully, and when utilizing P34HB to the PLA modification, can also improve the plasticity and the comfortableness of material.And the research modification intermingling material also finding when the content that gathers the 4 hydroxybutyric acid ester in the copolymer is 40%, to obtain good mechanical properties not only; Zoopery shows; Can also the control degradation cycle relatively stable through above-mentioned P34HB blending and modifying; Usually continue 3-6 month from beginning degraded to being absorbed fully, and good biocompatibility, the stomach wall after the repairing has compliance preferably.
Embodiment 1
Shown in accompanying drawing 1; Present embodiment relates to a kind of from the fixing organization sticking patch; It comprises polypropylene material wire side layer 1 and the degradation material hook surface layer 2 that is fixed on said polypropylene material wire side layer lower surface; Said hook surface layer comprises the ditch composition that has agnail in a large number, and little hook direction is consistent, length is identical; For example can adopt methods such as bonding, welding or stitching that degradation material hook surface layer 2 is fixed on polypropylene material wire side layer lower surface; Described degradation material is for gathering the blend of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer (P34HB) and polylactic acid (PLA), and the number-average molecular weight of wherein said polylactic acid is 10 * 10
4, the content of polylactic acid is 80wt% in blend; Said gathering, the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer was 30 * 10
4, the content in blend is 20wt%, the molar content of wherein in copolymer, gathering the 4 hydroxybutyric acid ester is 40%.The layer of polypropylene material wire side described in the accompanying drawing 1 be shaped as ellipse; Certainly can also be Long Circle, circle or other shape etc.
Present embodiment be a kind of real no tension force tissue patch from the fixing organization sticking patch, the polypropylene wire side on upper strata is used to repair damaged or weak area, and degradable hook mask has the location and prevent the function that sticking patch slides.In operation technique, fixedly hernia patch can fully launch certainly, avoids sutured, has saved operating time, has alleviated patient's slight illness.The hernia patch of present embodiment is used for inguinal hernia patient's preperitoneal space, the existence of little hook can guarantee sticking patch by means of the pressure fixing between the tissue in defect, the hook face is fitted in has the favorable tissue compliance on the soft tissue.
Claims (8)
1. one kind from the fixing organization sticking patch, the degradation material hook surface layer that it is characterized in that comprising the wire side layer He be fixed on said wire side layer lower surface.
2. claim 1 is described from the fixing organization sticking patch, it is characterized in that said wire side layer is a polypropylene material wire side layer.
3. claim 1 or 2 described from the fixing organization sticking patch is characterized in that described degradation material for gathering the blend of (3-butyric ester with gather the 4 hydroxybutyric acid ester) copolymer and polylactic acid, and the number-average molecular weight of wherein said polylactic acid is 9-15 * 10
4, the content of polylactic acid is 75-90wt% in blend; Said gathering, the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer was 25-40 * 10
4, the content in blend is 10-25wt%, the molar content of wherein in copolymer, gathering the 4 hydroxybutyric acid ester is 40%.
4. claim 1 or 2 described from the fixing organization sticking patch, the number-average molecular weight that it is characterized in that described polylactic acid is 9-12 * 10
4, the content of polylactic acid is 75-85wt% in blend, said gathering the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer be 25-35 * 10
4, the content in blend is 15-25wt%.
5. claim 1 or 2 described from the fixing organization sticking patch, the number-average molecular weight that it is characterized in that described polylactic acid is 10 * 10
4, the content of polylactic acid is 80wt% in blend, said gathering the number-average molecular weight of (3-butyric ester with gather 4 hydroxybutyric acid ester) copolymer be 30 * 10
4, the content in blend is 20wt%.
6. claim 1 or 2 described from the fixing organization sticking patch is characterized in that describedly being fixed as bonding, welding or sewing up.
7. claim 1 or 2 described from the fixing organization sticking patch, what it is characterized in that said wire side layer is shaped as circle, ellipse or Long Circle.
8. claim 1 or 2 described from the fixing organization sticking patch it is characterized in that said hook surface layer comprises that the ditch that has agnail in a large number forms, and little hook direction is consistent, length is identical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210238399.8A CN102772271B (en) | 2012-07-11 | 2012-07-11 | Self-retaining tissue patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210238399.8A CN102772271B (en) | 2012-07-11 | 2012-07-11 | Self-retaining tissue patch |
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| Publication Number | Publication Date |
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| CN102772271A true CN102772271A (en) | 2012-11-14 |
| CN102772271B CN102772271B (en) | 2015-08-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210238399.8A Active CN102772271B (en) | 2012-07-11 | 2012-07-11 | Self-retaining tissue patch |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104706442A (en) * | 2015-03-16 | 2015-06-17 | 克力木·阿不都热依木 | Patch special for esophageal hiatus hernia |
| CN105361975A (en) * | 2014-08-26 | 2016-03-02 | 上海微创医疗器械（集团）有限公司 | Hernia patch and production method thereof |
| CN106923930A (en) * | 2017-03-13 | 2017-07-07 | 上海瀚达医疗器械有限公司 | Patch based on novel weaving technology and shape and weaving method thereof |
| CN111867515A (en) * | 2018-01-31 | 2020-10-30 | 弹性钛合金植入物有限责任公司 | Self-fixating mesh implant based on titanium wire and bioabsorbable polymer |
| CN111938864A (en) * | 2020-08-20 | 2020-11-17 | 日照天一生物医疗科技有限公司 | Absorbable self-adhesive hernia repair patch and preparation method thereof |
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| US20090012350A1 (en) * | 2007-07-06 | 2009-01-08 | Claude Tihon | Partial cuff |
| CN101579540A (en) * | 2009-06-10 | 2009-11-18 | 都本立 | Antiblocking hernia patch and preparation method thereof |
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| WO2012048105A1 (en) * | 2010-10-06 | 2012-04-12 | Ams Research Corporation | Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions |
| CN102526812A (en) * | 2012-02-02 | 2012-07-04 | 北京博恩康生物科技有限公司 | Biodegradable multi-layered hernia repairing sheet and preparation methods thereof |
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2012
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| US20090012350A1 (en) * | 2007-07-06 | 2009-01-08 | Claude Tihon | Partial cuff |
| CN201389098Y (en) * | 2009-04-16 | 2010-01-27 | 北京天助畅运医疗技术有限公司 | Preperitoneal repair mesh |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105361975A (en) * | 2014-08-26 | 2016-03-02 | 上海微创医疗器械（集团）有限公司 | Hernia patch and production method thereof |
| CN105361975B (en) * | 2014-08-26 | 2017-09-12 | 上海微创医疗器械（集团）有限公司 | A kind of hernia paster and preparation method thereof |
| CN104706442A (en) * | 2015-03-16 | 2015-06-17 | 克力木·阿不都热依木 | Patch special for esophageal hiatus hernia |
| CN106923930A (en) * | 2017-03-13 | 2017-07-07 | 上海瀚达医疗器械有限公司 | Patch based on novel weaving technology and shape and weaving method thereof |
| CN111867515A (en) * | 2018-01-31 | 2020-10-30 | 弹性钛合金植入物有限责任公司 | Self-fixating mesh implant based on titanium wire and bioabsorbable polymer |
| CN111867515B (en) * | 2018-01-31 | 2024-01-30 | 钛合金纺织品公司 | Self-anchoring mesh implant based on titanium wire and bioabsorbable polymer |
| CN111938864A (en) * | 2020-08-20 | 2020-11-17 | 日照天一生物医疗科技有限公司 | Absorbable self-adhesive hernia repair patch and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102772271B (en) | 2015-08-26 |
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