CN102764108A - Remote intelligent molecular imaging system and application method thereof - Google Patents
Remote intelligent molecular imaging system and application method thereof Download PDFInfo
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Abstract
The invention discloses a remote intelligent molecular imaging system. The system comprises a local module and a remote module, wherein the local module and the remote module are used for transmitting control signals and data signals by a wired or wireless network. The invention further discloses a method for using the remote intelligent molecular imaging system. The system and the method are suitable for the continuous dynamic operations of researching occurrence and development of tumors of small animals and estimating medicinal cure effects by using a molecular imaging technique. In the whole continuous viewing process, the system finishes the signal collection automatically and provides physiological monitoring information of a target object. With the adoption of the intelligent and human-based design of the intelligent remote molecular imaging system, the requirements of users are considered furthest, the system can be operated remotely, and thus the time and the manpower are greatly saved. All in all, the system is convenient and safe in application and very wide in market prospect.
Description
Technical field
The present invention relates to the molecular imaging technical field, especially a kind of long-distance intelligent molecule image system and method for using thereof based on subject knowledges such as optical imagery theory, computer image processing technology, mathematical modelings.
Background technology
Along with developing rapidly of genomics, protein science and disease gene group; The diagnosis of disease is characterizing from traditional disease and is observing, conventional biochemical test detects; Develop into the microscopic feature understanding of several genes and molecular level; Wherein utilize the molecular imaging technology can be from generation, the evolution of gene, protein level heightened awareness disease; Can realize existing micro analysis institute can't substituted integral body, continuous, noninvasive special detection method, it is biological that theoretical and technology will provide brand-new prevention, diagnosis and treatment means at the body molecular imaging.
With traditional medical imaging technology comparatively speaking, molecular imaging is learned the basis that is conceived to constitute disease or pathological changes and is changed unusual with the gene molecule level, rather than the final result that is made up of the gene molecule change is carried out to picture.Under the help of special molecular probe; The molecular imaging technology can realize the noinvasive Real-time and Dynamic imaging in vivo of organism internal physiological or pathological process on cell, gene and molecular level, thus for researchs such as the mechanism of action of disease related gene functional localization, cell growth promoter and mutation process, new drug development provide detailed qualitative, location, quantitative data and effectively information obtain the means with analyzing and processing.
At present, traditional molecule image system can only carry out the manual control signal collection in the scene when toy is carried out bioluminescence or fluorescence imaging.And in the research of toy tumor development or curative effect of medication assessment; Need the variation of timing acquiring bioluminescence or fluorescence signal, gather a secondary data, lasting 24 hours such as per half or one hour; This just requires system to have remote monitoring and imaging capability; Only need regularly receive fluorescence data information, when using molecule image system, not delay other work, but remote monitoring target and collection bioluminescence and fluorescence signal.If the vital sign of target to be detected etc. occur unusual, system can report to the police from the trend remote control terminal, at this moment takes the handled measure to get final product.
Summary of the invention
The technical problem that (one) will solve
In view of this; Main purpose of the present invention provides a kind of long-distance intelligent molecule image system and method for using thereof; To solve traditional molecule image system when toy is carried out bioluminescence or fluorescence imaging; Can only on-the-spot carry out the manual control signal collection and limit the problem of its application, reach the remote monitoring target and gather bioluminescence and fluorescence signal purpose.
(2) technical scheme
For achieving the above object, the invention provides a kind of long-distance intelligent molecule image system, this system comprises local module 1 and far module 2, local module 1 is carried out the transmission of control signal and data signal with far module 2 through wired or wireless network.
In the such scheme, said local module 1 comprises the first signal transmitting and receiving module 11, local control treatment module 12, fluorescence signal acquisition module 13, monitoring modular 14 and destination object 15, wherein:
The first signal transmitting and receiving module 11 is connected with local control treatment module 12, is used to receive the data signal of local control treatment module 12, and it is sent to the secondary signal transceiver module 21 of far module 2 through wired or wireless network;
Local control treatment module 12; Be connected with the first signal transmitting and receiving module 11, fluorescence signal acquisition module 13 and monitoring modular 14; Be used to receive the monitoring feedback signal that monitoring modular 14 sends over; Receive the fluorescence signal that fluorescence signal acquisition module 13 sends over simultaneously, these two kinds of signals are carried out encoding process, and result is sent to the first signal transmitting and receiving module 11;
Fluorescence signal acquisition module 13 is connected with destination object 15 with local control treatment module 12, is used to obtain the fluorescence signal of destination object 15, and sends it to local control treatment module 12;
Monitoring modular 14 is connected with destination object 15 with local control treatment module 12, is used to obtain the status information of destination object 15;
In the such scheme, said fluorescence signal acquisition module 13 also is used to obtain the bioluminescence signal.
In the such scheme, said far module 2 comprises secondary signal transceiver module 21, Long-distance Control processing module 22, post-processing module 23, display module 24 and memory module 25, wherein:
Secondary signal transceiver module 21 is connected with Long-distance Control processing module 22, is used for the control signal that receiving remote control treatment module 22 is sent, and it is sent to the first signal transmitting and receiving module 11 of local module 1 through wired or wireless network;
Long-distance Control processing module 22 is connected with post-processing module 23 with secondary signal transceiver module 21, is used for the data signal that is received from secondary signal transceiver module 21 is carried out decoding processing, and result is sent to post-processing module 23;
In the such scheme, the post-processing operation of said post-processing module 23 comprises image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation.
In the such scheme; Local control treatment module 12 in the said local module 1 and the control signal between the Long-distance Control processing module 22 in the far module 2 or the transmission of data signal are all carried out through the first signal transmitting and receiving module 11, wired or wireless network and secondary signal transceiver module 21.
For achieving the above object, the present invention also provides a kind of method of using the described long-distance intelligent molecule image system of claim 1, is used to obtain signal one time, and this method comprises:
Step S1: Long-distance Control processing module 22 sends to secondary signal transceiver module 21 with control signal, and secondary signal transceiver module 21 sends to the first signal transmitting and receiving module 11 with this control signal through wired or wireless network;
Step S2: the first signal transmitting and receiving module 11 sends to local control treatment module 12 with this control signal; Local control treatment module 12 is provided with the parameters of fluorescence signal acquisition module 13 according to this control signal that receives; And the monitoring frequency of monitoring modular 14 and the threshold value of reporting to the police be set simultaneously;
Step S3: fluorescence signal acquisition module 13 requires to obtain data signal according to control signal; This data signal is fluorescence signal and/or bioluminescence signal; And the data signal of obtaining sent to local control treatment module 12, local control treatment module 12 sends to the first signal transmitting and receiving module 11 with data signal;
Step S4: the first signal transmitting and receiving module 11 sends to secondary signal transceiver module 21 through wired or wireless network with data signal, and secondary signal transceiver module 21 sends to Long-distance Control processing module 22 with data signal;
Step S5: Long-distance Control processing module 22 sends to post-processing module 23 with data signal, carries out various post-processing operation, and the signal that post-processing module 23 was handled is shown by display module 24 that respectively memory module 25 is preserved;
Step S6: monitoring modular 14 is according to the control signal requirement; Each item index of periodic monitor destination object 15; If monitoring information surpasses pre-set threshold, monitoring modular 14 will send alarm signal and give local control treatment module 12, and be ultimately delivered to Long-distance Control processing module 22; If monitoring modular 14 inspection each item indexs are normal, normal signal sent to local control treatment module 12 preserve.
In the such scheme, parameters described in the step S2 comprises time of exposure, pixel merging value and aperture size at least; Various post-processing operation described in the step S5 comprise image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation.
In the such scheme; The acquisition module 13 of fluorescence signal described in the step S3 requires to obtain data signal according to control signal; Fluorescence signal acquisition module 13 is to carry out signals collecting at a certain time interval and send to Long-distance Control processing module 22 according to the requirement that Long-distance Control processing module 22 is provided with; Perhaps fluorescence signal acquisition module 13 is to carry out video signal collective according to the requirement that Long-distance Control processing module 22 is provided with; And send to Long-distance Control processing module 22 in real time, and the fluorescence of destination object 15 or bioluminescence signal are handled in real time and shown the dynamic changing process of target object 15.
In the such scheme; Monitoring modular described in the step S6 14 is when each item index of periodic monitor destination object 15; If when finding to have monitoring index unusual, local control treatment module 12 can in time send to Long-distance Control processing module 22 with alarm signal, and request is in time handled; If all monitoring indexes are normal, monitoring modular 14 can be stored in local control treatment module 12 with monitoring index, when Long-distance Control processing module 22 is called Monitoring Data, redispatches.
(3) beneficial effect
The present invention compares prior art; Its beneficial effect is: the invention provides a kind of long-distance intelligent molecule image system and method for using thereof; Use this system can be, timing or obtain view data in real time through the collection of wired and wireless network Long-distance Control bioluminescence and fluorescence signal.The while monitoring module is with vital sign information such as the body temperature that regularly obtains the imageable target object, respiratory frequencys, and is unusual like monitor message display-object object situation, will send alarm signal through wired or wireless network to remote port in the very first time.This long-distance intelligent molecule image system is specially adapted to utilize the molecular image technology to carry out the dynamic continuously operation of research of toy tumor development and curative effect of medication assessment.In continuing the whole process of observing, this long-distance intelligent molecule image system will be accomplished signals collecting automatically, and the physiology monitoring information of destination object is provided.The intellectuality of system and human oriented design can long-rangely be operated farthest for the user considers, have practiced thrift time and efforts greatly.In a word, this long-distance intelligent molecule image system is easy to use, safety, has good market prospect.
Description of drawings
Fig. 1 is the sketch map according to the long-distance intelligent molecule image system of the embodiment of the invention.
The specific embodiment
For making the object of the invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, to further explain of the present invention.
Fig. 1 illustrates the sketch map according to the long-distance intelligent molecule image system of the embodiment of the invention, and this system comprises local module 1 and far module 2, and local module 1 is carried out the transmission of control signal and data signal with far module 2 through wired or wireless network.
Wherein, local module 1 comprises the first signal transmitting and receiving module 11, local control treatment module 12, fluorescence signal acquisition module 13, monitoring modular 14 and destination object 15; The first signal transmitting and receiving module 11 is connected with local control treatment module 12, is used to receive the data signal of local control treatment module 12, and it is sent to the secondary signal transceiver module 21 of far module 2 through wired or wireless network; Local control treatment module 12; Be connected with the first signal transmitting and receiving module 11, fluorescence signal acquisition module 13 and monitoring modular 14; Be used to receive the monitoring feedback signal that monitoring modular 14 sends over; Receive the fluorescence signal that fluorescence signal acquisition module 13 sends over simultaneously, these two kinds of signals are carried out encoding process, and result is sent to the first signal transmitting and receiving module 11; Fluorescence signal acquisition module 13 is connected with destination object 15 with local control treatment module 12, is used to obtain the fluorescence signal of destination object 15, and sends it to local control treatment module 12; Monitoring modular 14 is connected with destination object 15 with local control treatment module 12, is used to obtain the status information of destination object 15; Destination object 15 is connected with monitoring modular 14 with fluorescence signal acquisition module 13, is used to fluorescence signal acquisition module 13 object is provided, and for destination object monitoring modular 14 object is provided.Said fluorescence signal acquisition module 13 also is used to obtain the bioluminescence signal.
Far module 2 comprises secondary signal transceiver module 21, Long-distance Control processing module 22, post-processing module 23, display module 24 and memory module 25; Secondary signal transceiver module 21 is connected with Long-distance Control processing module 22, is used for the control signal that receiving remote control treatment module 22 is sent, and it is sent to the first signal transmitting and receiving module 11 of local module 1 through wired or wireless network; Long-distance Control processing module 22 is connected with post-processing module 23 with secondary signal transceiver module 21, is used for the data signal that is received from secondary signal transceiver module 21 is carried out decoding processing, and result is sent to post-processing module 23; Post-processing module 23; Be connected with Long-distance Control processing module 22, display module 24 and memory module 25; Be used for the data signal that is received from Long-distance Control processing module 22 is carried out post-processing operation, and the post-processing operation result is sent to display module 24 and memory module 25; Display module 24 is connected with post-processing module 23, is used to receive the data signal that post-processing module 23 sends over, and shows; Memory module 25 is connected with post-processing module 23, is used to receive the data signal that post-processing module 23 sends over, and stores.The post-processing operation of said post-processing module 23 comprises image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation.
Local control treatment module 12 in the said local module 1 and the control signal between the Long-distance Control processing module 22 in the far module 2 or the transmission of data signal are all carried out through the first signal transmitting and receiving module 11, wired or wireless network and secondary signal transceiver module 21.In the practical implementation process, can connect through cable network or wireless network between the first signal transmitting and receiving module 11 and the secondary signal transceiver module 21, each other transmission of control signals and data signal.
Local control treatment module 12 can be a single-chip microcomputer, has computing and memory function.Long-distance Control processing module 22 can be a CPU with post-processing module 23.Memory module 25 can be a calculator memory.Display module 24 can be made up of computer display card and display.Monitoring modular 14 can comprise body temperature trans, and the device of detected target object vital signs such as respirator is formed.Fluorescence signal acquisition module 13 can be accomplished obtaining of bioluminescence signal and fluorescence signal.Can carry out signal in certain time interval and obtain, also can carry out real-time signal and obtain with the speed of 25 frames.
Based on long-distance intelligent molecule image system shown in Figure 1, the method for using this long-distance intelligent molecule image system to obtain a signal comprises:
Step S1: Long-distance Control processing module 22 sends to secondary signal transceiver module 21 with control signal, and secondary signal transceiver module 21 sends to the first signal transmitting and receiving module 11 with this control signal through wired or wireless network;
Step S2: the first signal transmitting and receiving module 11 sends to local control treatment module 12 with this control signal; Local control treatment module 12 is provided with the parameters of fluorescence signal acquisition module 13 according to this control signal that receives; This parameters comprises time of exposure, pixel merging value and aperture size at least; And the monitoring frequency of monitoring modular 14 and the threshold value of reporting to the police be set simultaneously;
Step S3: fluorescence signal acquisition module 13 requires to obtain data signal according to control signal; This data signal is fluorescence signal and/or bioluminescence signal; And the data signal of obtaining sent to local control treatment module 12, local control treatment module 12 sends to the first signal transmitting and receiving module 11 with data signal;
Step S4: the first signal transmitting and receiving module 11 sends to secondary signal transceiver module 21 through wired or wireless network with data signal, and secondary signal transceiver module 21 sends to Long-distance Control processing module 22 with data signal;
Step S5: Long-distance Control processing module 22 sends to post-processing module 23 with data signal, carries out various post-processing operation, comprises image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation; The signal that post-processing module 23 was handled is shown by display module 24 that respectively memory module 25 is preserved;
Step S6: monitoring modular 14 is according to the control signal requirement; Each item index of periodic monitor destination object 15; If monitoring information surpasses pre-set threshold, monitoring modular 14 will send alarm signal and give local control treatment module 12, and be ultimately delivered to Long-distance Control processing module 22; If monitoring modular 14 inspection each item indexs are normal, normal signal sent to local control treatment module 12 preserve.
Wherein, The acquisition module 13 of fluorescence signal described in the step S3 requires to obtain data signal according to control signal; Fluorescence signal acquisition module 13 is to carry out signals collecting at a certain time interval and send to Long-distance Control processing module 22 according to the requirement that Long-distance Control processing module 22 is provided with; Perhaps fluorescence signal acquisition module 13 is to carry out video signal collective according to the requirement that Long-distance Control processing module 22 is provided with; And send to Long-distance Control processing module 22 in real time, and the fluorescence of destination object 15 or bioluminescence signal are handled in real time and shown the dynamic changing process of target object 15.Monitoring modular described in the step S6 14 is when each item index of periodic monitor destination object 15, and when having monitoring index unusual as if discovery, local control treatment module 12 can in time send to Long-distance Control processing module 22 with alarm signal, and request is in time handled; If all monitoring indexes are normal, monitoring modular 14 can be stored in local control treatment module 12 with monitoring index, when Long-distance Control processing module 22 is called Monitoring Data, redispatches.
Obtain the method for a signal based on this long-distance intelligent molecule image system of above-mentioned use, the present invention also provides a kind of specific embodiment that uses this long-distance intelligent molecule image system, and its step is following:
Step S10: Long-distance Control processing module 22 is sent initialization command through secondary signal transceiver module 21, wired or wireless network, the first signal transmitting and receiving module 11 to local control treatment module 12;
Step S20: the initialization command of local control treatment module 12 receiving remote control treatment modules 22 is provided with in the monitoring modular 14 monitoring frequency of temperature sensor and respiratory control machine monitoring and is 1 minute once, and sets the parameter threshold that sends alarm signal; Getting parms of fluorescence signal acquisition module 13 is set, selected fluorescence imaging, the first order fluorescence image was gathered at every interval in 1 hour, Continuous Observation 24 hours, time of exposure is 5s, aperture size is f/2.8; Local control treatment module 12 is provided with intervalometer, regularly reminds monitoring modular 14 and fluorescence signal acquisition module 13 to carry out work;
Step S30: every mistake 1 minute, the intervalometer of local control treatment module 12 are reminded it to carry out monitoring information and are obtained; Monitoring modular 14 obtains body temperature information and respiratory frequency information after receiving the order of local control treatment module 12, and sends it to local control treatment module 12; Local control treatment module 12 judges according to the preset threshold condition whether monitoring information is normal; If normal, monitoring information is kept at this locality; If exceed prior scope; It is unusual to explain that the destination object state takes place, and local control treatment module 12 is sent alarm signals, through the first signal transmitting and receiving module 11, wired or wireless network, secondary signal transceiver module 21; Finally send to Long-distance Control processing module 22, request is in time handled;
Step S40: every mistake 1 hour, the intervalometer of local control treatment module 12 remind its fluorescence signal to obtain; Fluorescence signal acquisition module 13 is received the order of local control treatment module 12, carries out the fluorescence signal collection, and view data is passed to local control treatment module 12.
Local control treatment module 12 through the first signal transmitting and receiving module 11, wired or wireless network, secondary signal transceiver module 21, finally sends to Long-distance Control processing module 22 with view data.Long-distance Control processing module 22 is given post-processing module 23 with image data transmission.
Step S50: post-processing module 23 is carried out viewdata signal analysis processing such as automated graphics is cut apart, number of photons statistics, pseudo-colours, and result is preserved by memory module 25, is shown by display module 24 simultaneously.
Above-described specific embodiment; The object of the invention, technical scheme and beneficial effect have been carried out further explain, and institute it should be understood that the above is merely specific embodiment of the present invention; Be not limited to the present invention; All within spirit of the present invention and principle, any modification of being made, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a long-distance intelligent molecule image system is characterized in that, this system comprises local module (1) and far module (2), and local module (1) is carried out the transmission of control signal and data signal with far module (2) through wired or wireless network.
2. long-distance intelligent molecule image system according to claim 1; It is characterized in that; Said local module (1) comprises the first signal transmitting and receiving module (11), local control treatment module (12), fluorescence signal acquisition module (13), monitoring modular (14) and destination object (15), wherein:
The first signal transmitting and receiving module (11) is connected with local control treatment module (12), is used to receive the data signal of local control treatment module (12), and it is sent to the secondary signal transceiver module (21) of far module (2) through wired or wireless network;
Local control treatment module (12); Be connected with the first signal transmitting and receiving module (11), fluorescence signal acquisition module (13) and monitoring modular (14); Be used to receive the monitoring feedback signal that monitoring modular (14) sends over; Receive the fluorescence signal that fluorescence signal acquisition module (13) sends over simultaneously, these two kinds of signals are carried out encoding process, and result is sent to the first signal transmitting and receiving module (11);
Fluorescence signal acquisition module (13) is connected with destination object (15) with local control treatment module (12), is used to obtain the fluorescence signal of destination object (15), and sends it to local control treatment module (12);
Monitoring modular (14) is connected with destination object (15) with local control treatment module (12), is used to obtain the status information of destination object (15);
Destination object (15) is connected with monitoring modular (14) with fluorescence signal acquisition module (13), is used to fluorescence signal acquisition module (13) object is provided, and for destination object monitoring modular (14) object is provided.
3. long-distance intelligent molecule image system according to claim 2 is characterized in that, said fluorescence signal acquisition module (13) also is used to obtain the bioluminescence signal.
4. long-distance intelligent molecule image system according to claim 1; It is characterized in that; Said far module (2) comprises secondary signal transceiver module (21), Long-distance Control processing module (22), post-processing module (23), display module (24) and memory module (25), wherein:
Secondary signal transceiver module (21) is connected with Long-distance Control processing module (22), is used for the control signal that receiving remote control treatment module (22) is sent, and it is sent to the first signal transmitting and receiving module (11) of local module (1) through wired or wireless network;
Long-distance Control processing module (22) is connected with post-processing module (23) with secondary signal transceiver module (21), is used for the data signal that is received from secondary signal transceiver module (21) is carried out decoding processing, and result is sent to post-processing module (23);
Post-processing module (23); Be connected with Long-distance Control processing module (22), display module (24) and memory module (25); Be used for the data signal that is received from Long-distance Control processing module (22) is carried out post-processing operation, and the post-processing operation result is sent to display module (24) and memory module (25);
Display module (24) is connected with post-processing module (23), is used to receive the data signal that post-processing module (23) sends over, and shows;
Memory module (25) is connected with post-processing module (23), is used to receive the data signal that post-processing module (23) sends over, and stores.
5. long-distance intelligent molecule image system according to claim 4 is characterized in that, the post-processing operation of said post-processing module (23) comprises image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation.
6. long-distance intelligent molecule image system according to claim 1; It is characterized in that; Local control treatment module (12) in the said local module (1) and the control signal between the Long-distance Control processing module (22) in the far module (2) or the transmission of data signal are all carried out through the first signal transmitting and receiving module (11), wired or wireless network and secondary signal transceiver module (21).
7. a method of using the described long-distance intelligent molecule image system of claim 1 is used to obtain signal one time, it is characterized in that this method comprises:
Step S1: Long-distance Control processing module (22) sends to secondary signal transceiver module (21) with control signal, and secondary signal transceiver module (21) sends to the first signal transmitting and receiving module (11) with this control signal through wired or wireless network;
Step S2: the first signal transmitting and receiving module (11) sends to local control treatment module (12) with this control signal; Local control treatment module (12) is provided with the parameters of fluorescence signal acquisition module (13) according to this control signal that receives; And the monitoring frequency of monitoring modular (14) and the threshold value of reporting to the police be set simultaneously;
Step S3: fluorescence signal acquisition module (13) requires to obtain data signal according to control signal; This data signal is fluorescence signal and/or bioluminescence signal; And the data signal of obtaining sent to local control treatment module (12), local control treatment module (12) sends to the first signal transmitting and receiving module (11) with data signal;
Step S4: the first signal transmitting and receiving module (11) sends to secondary signal transceiver module (21) through wired or wireless network with data signal, and secondary signal transceiver module (21) sends to Long-distance Control processing module (22) with data signal;
Step S5: Long-distance Control processing module (22) sends to post-processing module (23) with data signal, carries out various post-processing operation, comprises image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation; The signal that post-processing module (23) was handled is shown by display module (24) that respectively memory module (25) is preserved;
Step S6: monitoring modular (14) is according to the control signal requirement; Each item index of periodic monitor destination object (15); If monitoring information surpasses pre-set threshold; Monitoring modular (14) will send alarm signal and give local control treatment module (12), and be ultimately delivered to Long-distance Control processing module (22); If monitoring modular (14) inspection each item index is normal, normal signal is sent to local control treatment module (12) preserve.
8. the method for use long-distance intelligent molecule image system according to claim 7 is characterized in that parameters described in the step S2 comprises time of exposure, pixel merging value and aperture size at least; Various post-processing operation described in the step S5 comprise image denoising, stack pseudo-colours, number of photons statistics and Image Automatic Segmentation.
9. the method for use long-distance intelligent molecule image system according to claim 7; It is characterized in that; The acquisition module of fluorescence signal described in the step S3 (13) requires to obtain data signal according to control signal; Fluorescence signal acquisition module (13) is to carry out signals collecting at a certain time interval and send to Long-distance Control processing module (22) according to the requirement that Long-distance Control processing module (22) is provided with; Perhaps fluorescence signal acquisition module (13) is to carry out video signal collective according to the requirement that Long-distance Control processing module (22) is provided with; And send to Long-distance Control processing module (22) in real time, and the fluorescence of destination object (15) or bioluminescence signal are handled in real time and shown the dynamic changing process of target object (15).
10. the method for use long-distance intelligent molecule image system according to claim 7; It is characterized in that; Monitoring modular described in the step S6 (14) is when each item index of periodic monitor destination object (15); If when finding to have monitoring index unusual, local control treatment module (12) can in time send to Long-distance Control processing module (22) with alarm signal, and request is in time handled; If all monitoring indexes are normal, monitoring modular (14) can be stored in local control treatment module (12) with monitoring index, redispatches when calling Monitoring Data in Long-distance Control processing module (22).
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US20060026040A1 (en) * | 2004-07-28 | 2006-02-02 | Reeves Anthony P | System and method for providing remote analysis of medical data |
CN101766476A (en) * | 2009-07-08 | 2010-07-07 | 中国科学院自动化研究所 | Auto-fluorescence molecule image system |
US8082024B2 (en) * | 2004-01-16 | 2011-12-20 | Alfano Robert R | Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy |
-
2012
- 2012-07-26 CN CN2012102621290A patent/CN102764108A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8082024B2 (en) * | 2004-01-16 | 2011-12-20 | Alfano Robert R | Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy |
US20060026040A1 (en) * | 2004-07-28 | 2006-02-02 | Reeves Anthony P | System and method for providing remote analysis of medical data |
CN101766476A (en) * | 2009-07-08 | 2010-07-07 | 中国科学院自动化研究所 | Auto-fluorescence molecule image system |
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