CN102740915A - 无防腐剂的单剂量吸入器系统 - Google Patents

无防腐剂的单剂量吸入器系统 Download PDF

Info

Publication number
CN102740915A
CN102740915A CN2011800058399A CN201180005839A CN102740915A CN 102740915 A CN102740915 A CN 102740915A CN 2011800058399 A CN2011800058399 A CN 2011800058399A CN 201180005839 A CN201180005839 A CN 201180005839A CN 102740915 A CN102740915 A CN 102740915A
Authority
CN
China
Prior art keywords
container
liquid
shell
atomizing generator
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2011800058399A
Other languages
English (en)
Other versions
CN102740915B (zh
Inventor
约翰·S·巴顿
赖安·S·巴顿
郭美常
耶胡达·伊夫里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinese Dance Biopharmaceutical Co
Original Assignee
Dance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44257547&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102740915(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dance Pharmaceuticals Inc filed Critical Dance Pharmaceuticals Inc
Publication of CN102740915A publication Critical patent/CN102740915A/zh
Application granted granted Critical
Publication of CN102740915B publication Critical patent/CN102740915B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/587—Lighting arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Nozzles (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

一种雾化系统，包括可挤压的容器，该容器具有弹性的容器主体。该容器被构造成当被挤压一次时输送单位剂量的液体。该系统还包括雾化器，雾化器由限定喷口的外壳和布置于外壳中的雾化发生器构成。雾化发生器包括具有前表面和后表面的可振动膜，以及用于振动该膜的可振动元件。此外，外壳包括开口，该开口用于从容器接收单位剂量的液体，该开口提供到可振动膜的后表面的液体通道。

Description

无防腐剂的单剂量吸入器系统
相关申请的交叉引用
本申请要求申请日为2011年1月11日、申请号为U.S.13/004,662的优先权，该申请要求申请日为2010年1月12日、申请号为U.S.61/335,769的美国临时申请的优先权并且为部分继续申请，所有公开内容通过引用并入本文。
本申请还和待审查的申请日为2011年1月11日、申请号为U.S.13/004,645、名称为“用于喷雾的无防腐剂胰岛素制剂、系统和方法”的并且与本申请同一申请日递交的申请相关，其公开的全部内容通过引用并入本文。
技术领域
本发明总体涉及单剂量吸入器和胰岛素制剂容器。该吸入器分配雾化药物制剂，用于局部或者全身吸入药物而肺脏给药。本发明特别地、但不专用于给药无防腐剂的胰岛素剂量来治疗I型和/或II型糖尿病患者。
背景技术
现有用于雾化液体的多种类型的吸入器。例如，通过引用并入本文的美国专利U.S.5,586,550描述了一种吸入器，该吸入器包括分配设备，在该分配器中，具有锥形通孔的膜被震动，使得与膜的后表面接触的液体形成雾状从膜的前表面被分配。
尽管在雾化液体方面是有效的，但是这种吸入器对于某些应用不是特别地适用，例如，用于雾化肺部给药的单位剂量的胰岛素。
因此，本发明提供用于以可重复和可预料的方式输送胰岛素的吸入器。如下文所述，本发明的吸入器可以特定地用于肺部给药的液体胰岛素的雾化。
发明内容
本发明提供多种雾化系统，包括对吸入器供给液体的容器，以及使用这些容器的方法。在一个示例性实施方式中，本发明提供一种雾化系统，包括可挤压的容器，该容器具有弹性的容器主体。该容器构造成挤压一次时输送单位剂量的液体。
该系统还包括雾化器，该雾化器包括外壳，该外壳限定喷口，还包括设置在外壳中的雾化发生器。雾化发生器包括具有前表面和后表面的可振动膜和用于使所述膜振动的可振动元件。此外，外壳包括适用于从容器接收单位剂量的液体的开口。该开口提供通向可振动膜的后表面的液体通道。
在一个方面中，雾化器包括中空的针，该针构造成刺穿可挤压的容器并向所述可振动膜的后表面供给液体。此外，可挤压的容器可包括容纳一个单位剂量的泡罩。例如，该泡罩可以包括吹瓶-灌装-封口的容器，该容器内含无防腐剂的溶液。泡罩还可以包括容纳溶液的可挤压的主体、可拧断的顶部和用于显示溶液信息的标签。
在另一方面中，一个单位剂量的浓度范围从大约200个胰岛素单位（IU）/ml到大约800IU/ml。
在另一个实施方式中，该容器包括容纳一定体积的液体的瓶。在一方面中，该瓶可包括计量阀，该计量阀在该瓶每次被挤压时，可分配液体的离散液滴。在其他情况下，液滴的尺寸可以至少部分地基于瓶尖端的直径和液体的粘稠度被控制。
本发明还提供另一种雾化系统，其包括安瓿瓶形式的容器，该安瓿瓶包括容纳一个单位剂量的液体的毛细管。该系统还包括雾化器，该雾化器包括：外壳，该外壳限定喷口；和设置在外壳中的雾化发生器。该雾化发生器包括具有前表面和后表面的可振动膜和用于使膜振动的可振动元件。此外，该外壳包括适用于从容器接受单位剂量的液体的开口。此外，该开口提供通向可振动膜的后表面的液体通道。
在一个具体方面中，该安瓿瓶还包括可折断的顶部和可折断的底部。毛细管的尺寸设计成使得所述毛细管中的表面张力可以在顶部移除之后且底部移除之前防止液体泄露。
本发明的另一实施方式提供一种具有容器的雾化系统，该容器包括容纳大量液体的容器主体，以及柱塞装置，所述柱塞装置是可移动的，以在按设定距离操作所述柱塞装置之后从所述容器分配一个单位剂量的液体。该雾化器包括外壳，该外壳限定喷口，还包括设置在外壳中的雾化发生器。该雾化发生器包括具有前表面和后表面的可振动膜，以及用于使所述膜振动的可振动元件。此外，外壳包括用于从容器接收单位剂量的液体的开口。该开口提供通向可振动膜的后表面的液体通道。
在一个方面中，该容器还包括计量设备，该计量设备被旋转以控制所述柱塞的移动以便设定一个单位剂量的量。
附图说明
图1是根据本发明的分配设备和可挤压容器的一个实施方式的局部剖视的透视图。
图2是图1的分配设备和容器的更多细节的视图。
图3示出了图1的分配设备，示出了用于保持容器的底座和用于供给分配的液体到雾化发生器的针的更多细节。
图4是根据本发明的分配设备和可挤压瓶的另一个实施方式的透视图。
图5示出了根据本发明的用于分配单位剂量的液体的容器的另一个实施方式。
图6示出了当分配单位剂量的液体到图4的分配设备时的图5的容器。
图7示出了根据本发明的用于分配单位体积的液体的安瓿瓶的实施方式。
图8示出了图7中的末端被移除的安瓿瓶。
图9示出了图8中的顶端也被移除的并且被布置在分配设备中的安瓿瓶。
图10示出了用于分配单位体积的液体到图4中的分配设备的容器的另一个实施方式。
具体实施方式
该发明的某些方面描述了一种雾化设备，该雾化设备包括：外壳，该外壳限定分配出口；可振动膜，该可振动膜具有在出口处露出的前表面和用于容纳待分配的液体的后表面；以及振动机构，该振动机构连接到外壳并且可操作成振动该膜从而通过该膜分配液体的气雾。液体输送系统用于输送计量的液体到该膜的后表面。以这种方式，通过操作振动机构运行足以充分雾化后表面的测定量的液体的一个操作时段，测定量的液体在出口处是可分配的。
这种设备的一个优点是便于以单剂量分配基本上所有的与膜的后表面接触的液体，特别是当测定的剂量为相对小的体积时。通过分配全部剂量，该膜从一剂量到下一剂量基本上没有液体。因此，以这种方式，可以在连续使用之间的非使用期间可以避免液体和周围空气之间的接触。这一点对于药物制剂特别重要，因为这样可以消除在液体中使用防腐剂的需要并且避免蒸发损耗。例如，可以使用在以下专利中描述的多种无防腐剂的胰岛素制剂：申请号为U.S.13/004,645、名称为“用于雾化的无防腐剂胰岛素制剂、系统和方法”的美国专利申请，之前通过引用并入的与该专利申请同日申请的申请。
在一个实施方式中，液体供给系统可以包括包含药物制剂的可变形的薄壁泡罩（blister）。供给系统还包括机械压力机，其构造成使薄壁泡罩变形从而提供单个的无防腐剂的单位剂量。压力机构设有分配站，该分配站设有穿刺针，该穿刺针可操作成在致动时刺穿泡罩并释放其内容物。
在一个方面，针具有两端，其第一端从分配站的表面突起，其第二端延伸至雾化发生器的后表面。在使用中，泡罩安置在分配站内以及压力机构迫使泡罩向针移动，针刺穿薄壁。以这种方式，针具有用于使液体从泡罩移动到可振动膜的后表面的管道。当压力机构释放时，泡罩伸展并恢复到其自然位置。这种伸展产生抽吸力使得从针中移除液体并防止干涸和堵塞。
在另一方面中，泡罩具有可以弹性伸展和压缩的波纹管形的几何结构。术语“弹性伸展和压缩”包括当泡罩被充分压缩时，内部压力仍在所用材料的弹性范围内，因此，当压力机构释放时，泡罩可以返回到其自然位置。在一个具体的方面，药物制剂填充泡罩的至少80%的内部容积并且更优选地多于90%的容积。这防止了液体的运动，液体的运动在某些情况下可导致组合物的凝聚。
方便地，针的末端在其近端被定位到可振动膜的后表面。此外，外壳可限定在空气进口和出口端口之间连通的管道。分配出口位于管道中的空气入口和出口端口中间，使得膜的前表面在管道中暴露于空气。出口端口可以是用于吸入器的喷口或者用于鼻腔使用的适配器。
在需要良好雾化的液体通过喷口被携带到吸入气流中时，这种装置对于吸入的药物液体产品的给药特别有用。这种液体的一个实例是胰岛素组合物。
参照图1将描述吸入器的一个实施方式。图1显示了单剂量吸入器100和用于供给测数量的胰岛素到吸入器的单位剂量泡罩201的局部剖视图。吸入器100包括两个组件102和组件112。第一组件102限定用于电子电路和电池的隔室，以及第二组件112限定具有分配出口105的外壳，并包含可振动膜雾化发生器108和分配机构104。
雾化发生器108具有在出口管道111处露出的前表面和在使用中与待分配的液体接触的后表面109。雾化发生器108连接到组件112的外壳并且可操作将活性药物制剂以雾化形式分配穿过喷口105。在美国专利5,164,740；6,629,646；6,926,208；7,108,197；5,938,117；6,540,153；6,540,154；7,040,549；6,921,020；7,083,112；7,628,339；5,586,550；5,758,637；6,085,740；6,467,476；6,640,804；7,174,888；6,014,970；6,205,999；6,755,189；6,427,682；6,814,071；7,066,398；6,978,941；7,100,600；7,032,590；7,195,011中描述了可以使用的示例性的雾化发生器，这些专利通过引用并入本文。这些参考文献描述了示例性的雾化发生器、制造这样的雾化发生器的方法和供给液体到雾化发生器的方法，对至少这些特征通过引用并入本文。雾化发生器可以包括可振动膜，该可振动膜具有锥形通孔，该锥形通孔的尺寸在大约3μm到大约8μm的范围内，优选的从大约3μm到大约6μm，在一些情况下，大约4μm。膜可以为圆拱形并且由环绕通孔的环形压电元件振动。膜的直径范围可以从约5mm到约8mm。膜的厚度范围可以是从大约50微米到大约70微米。通常，膜将以从大约50kHz到150kHz的范围内的频率而振动。
每次分配系统操作时，其提供了从单位剂量泡罩201输送测定量的液体到雾化发生器的后表面109。因此，对于每次使用，通过雾化发生器的操作在喷口出口105处分配计量的雾化药物制剂。
泡罩201包含待分配的预定量的活性药物制剂。在一个实施方式中，泡罩201包括大约80到大约120微升的胰岛素。下限通常为至少大约15微升，以及上限通常为大约1000微升到大约2000微升。一个具体的应用范围是大约80微升到大约120微升，浓度为大约100个胰岛素单位/毫升或者更大，以及更优选地为大约200-800个单位/毫升之间，在一些情况下可以高达2500个单位/毫升。泡罩201用薄壁可变形材料制成。由于胰岛素对机械搅拌敏感，泡罩201被充填接近其全部容积。具体地，超过80%的容积被充填胰岛素。
吸入器100还包括分配站，该分配站被构造成将泡罩201的内容物分配到雾化发生器108。分配站包括旋臂元件104和泡罩底座107。泡罩底座107具有可以径向匹配泡罩201的凸形形状的凹形形状。泡罩底座107还包括注射针112，该注射针建立从泡罩201到振动雾化发生器108的流体通道。针112包括两段。第一段112A从分配底座延伸并垂直于泡罩底座107向外突出。第二端112B朝着雾化发生器108向内延伸并且在封闭的近侧内被置于雾化发生器108的可振动膜的后侧。通常，第二端112B从雾化发生器108的可振动膜开始算小于5mm并且更优选的小于2mm。注射针112可以由不锈钢合金型号316制成，其规格尺寸从22G（gage）到26G。第一段112A具有锋利的斜的穿刺尖端。在使用中，泡罩201被置于凹陷的底座107上并且随后旋臂104在箭头115的方向上被逆时针旋转。
方便地，加在旋臂104上的力可以由拇指按压臂104的弯曲部分而施加。这一动作迫使泡罩向针的穿刺尖端112A，其接着刺穿泡罩201并接着借助针112穿过针的出口112B挤压泡罩201的内容物并且到雾化发生器108上。当旋臂104被完全压缩时，全部剂量被输送到雾化发生器108的可振动膜。
图2示出雾化发生器108的可振动膜109的更多细节。当泡罩201的内容物被完全分配时，指示灯120开始闪烁，告诉患者吸入器100可以使用了。在此不久之后的任一时刻，患者可以通过喷口105吸入。患者吸入量通过流量传感器探测，其反过来激活雾化发生器108以产生雾化颗粒进入管道111。气雾沿着箭头121显示的方向夹带在吸入气流中，并通过呼吸系统流至患者的肺部。当所有剂量被雾化（这可能需要一次或多次呼吸）时，“剂量结束”指示灯121第二次亮，来指示患者所有剂量已经被输送。当至少95%的剂量被输送，更优选95%的剂量被输送，更优选当超过99%的剂量被输送时，全部剂量的给药被实现。在一个实施方式中，到雾化发生器的开口漏斗足够大使得输送到雾化发生器的液体全部被输送。为了接收这些剂量，患者可能需要采取多次吸入或者一次吸入，这取决于输送到网格的量和患者的肺活量。每次吸入需要做深呼吸以保证气雾深入到达肺部。
当泡罩201的内容物被吸入之后剂量结束指示灯120被驱动时，空的泡罩可以被移出并丢弃。当拇指加在旋臂104上的压力释放时，泡罩伸展到其原来的形状。伸展在泡罩201内部产生真空，从而从针将任何附着的流体吸回返回到泡罩，从而保持针内部的干燥以防止材料变干和堵塞。此外，为了防止细菌可能感染针的内表面和/或外表面，针112可以用基于涂层等的银涂覆。
图3示出分配站的凹陷的底座107更多的细节。底座107具有孔117，孔117提供进入到雾化发生器108附近的吸入器内部的通道。这允许清洁剂和冲洗的水供给到雾化发生器108。
图4提供另一种用于吸入器500的输送系统，该系统利用无防腐剂分配器550和喷嘴551以分配一定量的无防腐剂的药物制剂通过开口501进入雾化发生器。吸入器500可以与吸入器100相同的方式被构造，并可以包括同样的雾化发生器。开口501具有漏斗形且向下渐缩到小的开口502，由此形成斜坡503。分配器550是均匀滴式、无防腐剂的分配器，该分配器激活时通过喷嘴551的尖端转移单个液滴。优选地，液滴的体积小于大约200微升。通过在垂直于容器550的纵向轴线的方向上挤压容器550，剂量被分配。在每次驱动时，固定容积的单个液滴通过喷嘴551被转移。
一个示例性的分配器是Apter OSD分配器，其由Ing.Erich Pfeiffer GmbH开发。这种容器构造有可挤压的瓶，该瓶被挤压来分配液滴。当释放时，喷嘴防止微生物污染物进入剩余的液体中。这通过防止液体回流到容器中的尖端密封件完成的。尖端密封机构包括弹簧，该弹簧保持尖端密封件在通常的封闭位置中的合适位置。当挤压瓶时，液体在密封件和帽之间流动，直到产生足够的压力以克服弹簧的力。以这种方式，可分配单个液滴。分配之后，尖端密封件再次封闭防止液体返回容器中。为了减少在瓶中累积的真空，容器的侧面具有小孔以允许空气进入弹性室。液滴的尺寸可以通过包括顶端尺寸和液体粘性的多个因素加以控制。
在使用中，喷嘴551对准开口501，使得液滴分配到斜坡503并流经开口502到雾化发生器。优选地，斜坡503的角度相对于开口502的轴线大于约30度。开口501的直径为大约10mm到大约15mm，并且开口502的直径最小为大约5mm。无防腐剂的分配器550中的药物液体可以被包含可收缩袋中，以防止过度搅拌并且可收缩袋可以由机械搅动而损坏。例如，比如胰岛素的蛋白质对机械搅动敏感。使用可收缩袋可以限制不需要的搅拌。
在另一个实施方式中，使用容器600来替代图5中描述的类型的容器。容器600包括采用吹瓶-灌装-封口工艺制成的泡罩602。容器600与图1中的容器201类似，其中当泡罩602被挤压时给药单位剂量。
泡罩602包括可挤压的主体604，该主体具有标签606和可扭断的顶部608。主体604的尺寸设计为用于保持单位剂量的液体，并且标签66可以包括例如批号、日期等的各种类型的识别信息。扭断顶部608提供打开泡罩602的一个容易的方式，使得可以分配液体。
此外，参照图6将描述使用泡罩602供给单位剂量的液体到吸入器500。当准备好接受治疗的时候，用户拿取泡罩602并扭断顶部608。典型的，泡罩602被保持直立使得没有液体漏出。在一些情况下，当顶部608被移除时形成的开口可以设计成足够小的尺寸以防止液体漏出。泡罩602在开口501上方移动，主体604被挤压以排出全部量的液体610到开口501中，其中液体流经开孔502排出并进入雾化器。以这种方式，泡罩602作为可用手挤压的、用于无防腐剂的溶液的一次性容器。吹瓶-灌装-封口工艺的使用具有的特别优点在于泡罩602可以以较低的成本制造的同时可以储存无防腐剂的溶液。此外，计量方法简单，仅需要移除顶部和挤压泡罩。
图7示出用于分配待雾化的单位体积液体的安瓿瓶700的实施方式。安瓿瓶700包括细长的主体702，该主体限定保持单位体积的液体704的毛细管。安瓿瓶700还包括顶端706和底端708，顶端706和底端708例如可以通过折断而从主体702移除。主体702可以由基本为刚性的材料制成，该材料具有足够的刚性以使两端轻易被折断。
当准备分配液体到吸入器中时，顶端706被移除，如图8所示。当安瓿瓶700被倒置时，例如当插入安瓿瓶700到吸入器时，主体702中的表面张力防止任何液体704泄露。
图9显示了插入吸入器720后的图8的安瓿瓶700。吸入器720可以与本文描述的其他实施方式相同的方式制成，吸入器720包括用于控制具有可振动网格726的雾化发生器的运行的电子器件722。吸入器720具有细长的开口730，安瓿瓶700在顶端706被移除后插入开口730中。一旦就位，端部708被折断，这样允许液体704从安瓿瓶700排出并且到可振动网格726的后表面，如图9所示。由于网格726的振动，液体被雾化并被引导至患者可以吸入药剂的喷口732。在雾化后，安瓿瓶700可以从吸入器720上移除并丢弃。
图10显示了用于将单位体积的液体分配到分配设备500中的容器800的另一个实施方式，分配设备500在前面参照图4描述过。容器800包括容器主体802，容器主体802限定用于保持待分配的一定量的液体的储存器804。柱塞806用于迫使储存器804中的液体穿过容器800的分配端。容器800还包括齿轮计量机构802，齿轮计量机构802旋转或者“拨号”（dialed）以便控制柱塞806的移动范围。此外，致动器814被按压，以使柱塞806移动计量机构允许的量。以这种方式，用户使用计量机构可以简单地“测量一个剂量”的液体并且接着按压致动器814以便分配测定量的液体到孔501内，在孔内液体将被供给到雾化机构。
容器800可以构造成一次性使用或多次使用。当可重复使用时，储存器804可以包括插入到储存器804限定的空间内的筒。示例性的体积尺寸可以为约1ml、1.8ml或3ml筒，该筒可由玻璃、LDPE或类似材料制成。
为了清楚和理解的目的，现已经详细描述了本发明。然而，应该理解，在所附的权利要求书的保护范围内实施某些变化和变型。

Claims (11)

1.一种雾化系统，其包括：
可挤压的容器，所述容器包括弹性的容器主体，所述容器被构造成当被挤压一次时输送单位剂量的液体；
雾化器，所述雾化器包括：
外壳，所述外壳限定喷口；
雾化发生器，所述雾化发生器设置于所述外壳中，其中所述雾化发生器包括具有前表面和后表面的可振动膜和用于使所述膜振动的可振动元件；
其中所述外壳包括开口，所述开口用于从所述容器接收单位剂量的液体，其中所述开口提供通向所述可振动膜的后表面的液体通道。
2.如权利要求1所述的雾化系统，其中所述雾化器包括中空的针，所述针被构造成刺穿所述可挤压的容器并向所述可振动膜的后表面供给液体。
3.如权利要求1所述的雾化系统，其中所述可挤压容器包括容纳一个单位剂量的泡罩。
4.如权利要求3所述的雾化系统，其中所述泡罩包括吹填密封的容器，所述容器容纳无防腐剂的溶液。
5.如权利要求4所述的雾化系统，其中所述泡罩还包括用于容纳所述溶液的可挤压的主体、可扭断的顶部和用于显示溶液信息的标签。
6.如权利要求3所述的雾化系统，其中一个单位剂量的浓度范围从大约200IU/ml到大约800IU/ml。
7.如权利要求1所述的雾化系统，其中所述容器包括容纳一定体积的液体的瓶，并且其中所述瓶构造成当所述瓶被挤压时分配一定体积的离散液滴。
8.一种雾化系统，包括：
容器，所述容器包括安瓿瓶，所述安瓿瓶包含容纳一个单位剂量的液体的毛细管；
雾化器，所述雾化器包括：
外壳，所述外壳限定喷口；
雾化发生器，所述雾化发生器设置在所述外壳中，其中所述雾化发生器包括具有前表面和后表面的可振动膜和用于使可振动膜振动的可振动元件；
其中所述外壳包括开口，所述开口用于从所述容器接收单位剂量的液体，其中所述开口提供通向所述可振动膜的后表面的液体通道。
9.如权利要求8所述雾化系统，其中所述安瓿瓶还包括可折断的顶部和可折断的底部，以及其中所述毛细管的尺寸使得所述毛细管中的表面张力在所述顶部移除之后和所述底部移除之前防止液体泄露。
10.一种雾化系统，包括：
容器，所述容器包括容纳大量液体的容器主体，以及柱塞装置，所述柱塞装置是可移动的，以在按设定距离操作所述柱塞装置之后从所述容器分配一个单位剂量的液体；
雾化器，包括：
外壳，所述外壳限定喷口；
雾化发生器，所述雾化发生器设置在所述外壳中，其中所述雾化发生器包括具有前表面和后表面的可振动膜和用于使所述可振动膜振动的可振动元件；
其中所述外壳包括开口，所述开口用于从所述容器接收单位剂量的液体，其中所述开口提供通向所述可振动膜的后表面的液体通道。
11.如权利要求10所述的雾化系统，其中所述容器还包括计量设备，所述计量设备被旋转来控制所述柱塞的移动以便设定一个单位剂量的量。
CN201180005839.9A 2010-01-12 2011-01-12 无防腐剂的单剂量吸入器系统 Active CN102740915B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33576910P 2010-01-12 2010-01-12
US61/335,769 2010-01-12
US13/004,662 US8950394B2 (en) 2010-01-12 2011-01-11 Preservative-free single dose inhaler systems
US13/004,662 2011-01-11
PCT/US2011/020925 WO2011088070A1 (en) 2010-01-12 2011-01-12 Preservative-free single dose inhaler systems

Publications (2)

Publication Number Publication Date
CN102740915A true CN102740915A (zh) 2012-10-17
CN102740915B CN102740915B (zh) 2016-01-20

Family

ID=44257547

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180005839.9A Active CN102740915B (zh) 2010-01-12 2011-01-12 无防腐剂的单剂量吸入器系统
CN201180005836.5A Active CN102740911B (zh) 2010-01-12 2011-01-12 用于雾化的无防腐剂胰岛素制剂和系统以及方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180005836.5A Active CN102740911B (zh) 2010-01-12 2011-01-12 用于雾化的无防腐剂胰岛素制剂和系统以及方法

Country Status (11)

Country Link
US (8) US8950394B2 (zh)
EP (2) EP2523716B1 (zh)
KR (2) KR101828426B1 (zh)
CN (2) CN102740915B (zh)
AU (2) AU2011205443B2 (zh)
BR (2) BR112012017177B1 (zh)
CA (2) CA2786128C (zh)
ES (1) ES2698401T3 (zh)
MX (2) MX340395B (zh)
RU (2) RU2559171C2 (zh)
WO (2) WO2011088071A1 (zh)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105307620A (zh) * 2013-04-16 2016-02-03 当斯生物制药有限公司 液体分配和用于分配液体的方法
CN106102808A (zh) * 2014-02-25 2016-11-09 帕里医药有限责任公司 吸入器和吸入器组
CN110167618A (zh) * 2016-12-09 2019-08-23 微计量医疗公司 吸入器
CN111356494A (zh) * 2017-10-23 2020-06-30 耐布太克医辽产品科恩股份有限公司 喷雾器中的自动加药
CN112891688A (zh) * 2014-08-28 2021-06-04 诺顿（沃特福特）有限公司 吸入器的依从性辅助模块
US11833291B2 (en) 2010-01-12 2023-12-05 Aerami Therapeutics, Inc. Preservative-free single dose inhaler systems

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9022027B2 (en) 2004-02-20 2015-05-05 Pneumoflex Systems, Llc Nebulizer with intra-oral vibrating mesh
US8109266B2 (en) 2004-02-20 2012-02-07 Pneumoflex Systems, Llc Nebulizer having flow meter function
US20130269684A1 (en) * 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US10842951B2 (en) 2010-01-12 2020-11-24 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto
US9545488B2 (en) 2010-01-12 2017-01-17 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US9068566B2 (en) 2011-01-21 2015-06-30 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
EP2817051B1 (en) * 2012-02-22 2017-07-26 Altria Client Services LLC Electronic smoking article
US8984650B2 (en) 2012-10-19 2015-03-17 Pearson Education, Inc. Privacy server for protecting personally identifiable information
EP2735328A1 (en) 2012-11-27 2014-05-28 PARI Pharma GmbH Fluid reservoir for an aerosol generation device, combination of fluid reservoir and primary fluid package, and aerosol generation device for use with the fluid reservoir
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
ES2734570T3 (es) * 2013-04-16 2019-12-10 Dance Biopharm Inc Distribución de líquido
WO2014179083A1 (en) * 2013-05-02 2014-11-06 Pneumoflex Systems, Llc Nebulizer with intra-oral vibrating mesh
US11278682B2 (en) 2014-11-09 2022-03-22 Sipnose Ltd. Device and method for aerosolized delivery of substance to a natural orifice of the body
US11116914B2 (en) 2014-11-09 2021-09-14 Sipnose Ltd. Device and method for aerosolized delivering of substance to a natural orifice of the body
US11992604B2 (en) 2014-11-09 2024-05-28 Sipnose Ltd. Devices and methods for delivering a substance to a body cavity
DE202013105715U1 (de) * 2013-08-22 2014-02-19 Sipnose Ltd. Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers
US11471618B2 (en) 2014-11-09 2022-10-18 Sipnose Ltd. Adjustable dosing delivery and multi sectioned drug compartment
US10307550B2 (en) * 2014-06-09 2019-06-04 Dance Biopharm Inc. Liquid drug cartridges and associated dispenser
USD765831S1 (en) * 2014-06-17 2016-09-06 Koninklijke Philips N.V. Mouthpiece for handheld respiratory device
US11273271B2 (en) 2014-07-01 2022-03-15 Aerami Therapeutics, Inc. Aerosolization system with flow restrictor and feedback device
US10471222B2 (en) * 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
US10857313B2 (en) * 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
EP3261648B1 (en) * 2015-02-25 2023-12-06 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto
WO2016164830A1 (en) * 2015-04-10 2016-10-13 Lagunita Llc Piezoelectric dispenser with replaceable ampoule
US10455863B2 (en) 2016-03-03 2019-10-29 Altria Client Services Llc Cartridge for electronic vaping device
US10433580B2 (en) 2016-03-03 2019-10-08 Altria Client Services Llc Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge
US10368580B2 (en) 2016-03-08 2019-08-06 Altria Client Services Llc Combined cartridge for electronic vaping device
US10357060B2 (en) 2016-03-11 2019-07-23 Altria Client Services Llc E-vaping device cartridge holder
US10368581B2 (en) 2016-03-11 2019-08-06 Altria Client Services Llc Multiple dispersion generator e-vaping device
CN109069750B (zh) 2016-04-25 2021-09-07 科斯卡家族有限公司 药物输送系统
US20210113784A1 (en) * 2017-03-20 2021-04-22 Vectura Delivery Devices Limited Container for cleaning the membrane of a nebulizer
JP7227163B2 (ja) 2017-06-10 2023-02-21 アイノビア，インコーポレイティド 流体を取扱い、目に流体を送出するための方法および装置
EP3675926B1 (en) 2017-08-30 2024-02-07 Novo Nordisk A/S Flow communication unit with preservative
CN111032126B (zh) 2017-08-30 2024-01-09 诺和诺德股份有限公司 用于具有较少防腐剂的药物的多次使用药物递送装置
EP3710086A4 (en) 2017-11-17 2021-11-17 Koska Family Limited SYSTEMS AND PROCESSES FOR FLUID DISPENSERS
CN108080203B (zh) * 2018-02-01 2023-10-27 佛山市顺德区雅洛特电器有限公司 一种超声雾化精油器
CN114144217A (zh) * 2019-05-07 2022-03-04 金德瓦药物控释有限公司 警告系统、吸入器和产生警告的方法
BR112021026616A2 (pt) 2019-07-03 2022-02-15 Aerami Therapeutics Inc Composições de exenatidas para administração pulmonar e uso das mesmas
US20220265940A1 (en) 2019-08-02 2022-08-25 Stamford Devices Limited Buccal administration of aerosol
EP4265287A4 (en) * 2020-12-18 2024-08-28 Shenzhen Smoore Technology Ltd ELECTRONIC NEBULIZATION DEVICE
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564129A (en) * 1983-01-27 1986-01-14 Hoechst-Roussel Pharmaceuticals Inc. Dosage dispensing unit
CN2406684Y (zh) * 1999-11-26 2000-11-22 北京亚都科技股份有限公司 医用雾化器
CN1303309A (zh) * 1998-06-11 2001-07-11 艾若根公司 改进的在便携式吸入器内存储化合物的方法和设备
US20040256488A1 (en) * 2001-03-20 2004-12-23 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US20070163572A1 (en) * 2004-02-20 2007-07-19 Addington W R Intra-oral nebulizer
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US20090157037A1 (en) * 2007-10-12 2009-06-18 Laxmi Iyer Inhalation drug delivery

Family Cites Families (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1947310A (en) 1933-04-07 1934-02-13 Warren M Sample Liquid dispenser
US2463922A (en) 1946-02-15 1949-03-08 William E Turner Liquid dispenser with receptacle operated outlet valve
GB1383761A (en) 1971-02-25 1974-02-12 Woodcraft Dc Inhalation device for use with an aerosol container
US3874380A (en) 1974-05-28 1975-04-01 Smithkline Corp Dual nozzle intranasal delivery device
US4771769A (en) 1982-12-20 1988-09-20 Schering Corporation Hand held metered spray dispenser
DE3339180C2 (de) 1983-10-28 1993-10-14 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
DE3734306A1 (de) 1987-10-10 1989-04-27 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer fliessfaehige medien
US5152456A (en) * 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
US5060642A (en) 1990-01-05 1991-10-29 Gilman Thomas H Wound dressing with air permeable bacteria impermeable reservoir
GB9015077D0 (en) 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
DE69127826T2 (de) 1990-12-17 1998-04-09 Minnesota Mining & Mfg Inhalationsgerät
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
US5938117A (en) * 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US6540154B1 (en) * 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US6629646B1 (en) 1991-04-24 2003-10-07 Aerogen, Inc. Droplet ejector with oscillating tapered aperture
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
GB2272389B (en) 1992-11-04 1996-07-24 Bespak Plc Dispensing apparatus
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5915378A (en) 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5694919A (en) 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US6131567A (en) 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
CH686872A5 (de) * 1993-08-09 1996-07-31 Disetronic Ag Medizinisches Inhalationsgeraet.
US5479920A (en) 1994-03-01 1996-01-02 Vortran Medical Technology, Inc. Breath actuated medicinal aerosol delivery apparatus
AU689217B2 (en) 1994-03-07 1998-03-26 Novartis Ag Methods and compositions for pulmonary delivery of insulin
RU2175556C2 (ru) * 1994-03-07 2001-11-10 Инхейл Терапьютик Системз Способы и композиции для легочной доставки инсулина
US5385180A (en) 1994-06-09 1995-01-31 Empak, Inc. Liquid saver funnel system
US5586550A (en) * 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US6782886B2 (en) * 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6427682B1 (en) * 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US5823179A (en) * 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US5915376A (en) * 1996-02-20 1999-06-29 Mclean; Vincent C. Evacuated solar collector
WO1998022290A1 (en) 1996-11-18 1998-05-28 Pbt International Ltd. An inkjet cartridge refill device
US6712762B1 (en) 1997-02-28 2004-03-30 Ors Diagnostic, Llc Personal computer card for collection of real-time biological data
US20060239930A1 (en) * 1997-08-04 2006-10-26 Herbert Lamche Process for nebulizing aqueous compositions containing highly concentrated insulin
DE19819748A1 (de) 1998-05-02 1999-11-04 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US6440929B1 (en) * 1998-07-27 2002-08-27 Emisphere Technologies, Inc. Pulmonary delivery of active agents
GB9820937D0 (en) 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6635617B1 (en) * 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
US6211144B1 (en) * 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6489292B1 (en) * 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
JP2002529514A (ja) 1998-11-18 2002-09-10 ノボ ノルディスク アクティーゼルスカブ フェノール及びクレゾールを要さない安定なインスリン水性調製物
US6312665B1 (en) 1998-12-21 2001-11-06 Generex Pharmaceuticals Incorporated Aerosol formulations for buccal and pulmonary application
US6164498A (en) 1999-09-01 2000-12-26 Mcneil-Ppc. Inc. Pump dispenser
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
EP1217942A1 (en) 1999-09-24 2002-07-03 Healthetech, Inc. Physiological monitor and associated computation, display and communication unit
JP2003511124A (ja) 1999-10-01 2003-03-25 グラクソ グループ リミテッド 患者遠隔評価システム
GB0003197D0 (en) 2000-02-11 2000-04-05 Aid Medic Ltd Improvements in and relating to controlling drug delivery
GB2360219A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
AU2001263098A1 (en) * 2000-05-12 2001-11-26 Iep Pharmaceutical Devices, Inc. Powder/liquid metering valve
JP4147234B2 (ja) 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
GB2368061B (en) 2000-10-20 2005-05-11 Gw Pharmaceuticals Ltd Dose dispensing apparatus
CN2461580Y (zh) 2001-02-09 2001-11-28 鲁崇恭 超声波雾化胰岛素吸入装置
US6546927B2 (en) * 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
DE60205093T2 (de) 2001-03-15 2006-05-24 The Government of the United States of America, as represented by the Secretary, Centers for Disease Control and Prevention Vernebler mit kühlkammer
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
JP4812190B2 (ja) * 2001-06-20 2011-11-09 オリンパス株式会社 画像ファイル装置
US20080177154A1 (en) 2001-08-13 2008-07-24 Novo Nordisk A/S Portable Device and Method Of Communicating Medical Data Information
IL159864A0 (en) 2001-08-13 2004-06-20 Novo Nordisk As Portable device and method of communicating medical data information
CA2459867C (en) 2001-09-06 2012-03-13 Microdose Technologies, Inc. Adaptors for inhalers to improve performance
US20080148193A1 (en) 2001-09-13 2008-06-19 John Moetteli System and method of efficient web browsing
US20030068361A1 (en) 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
US6684880B2 (en) 2001-12-04 2004-02-03 Hewlett-Packard Development Company, L.P. Applicator for dispensing bioactive compositions and methods for using the same
WO2003051424A2 (en) 2001-12-17 2003-06-26 Mcfarland Joseph L Jr Portable, handheld, pneumatic driven medicinal nebulizer
MXPA04006629A (es) 2002-01-07 2004-11-10 Aerogen Inc Aparatos y metodos para nebulizar fluidos para inhalacion.
AU2003203043A1 (en) * 2002-01-15 2003-07-30 Aerogen, Inc. Methods and systems for operating an aerosol generator
FR2835435B1 (fr) * 2002-02-01 2004-04-23 Diffusion Tech Francaise Sarl Dispositif de protection du circuit sonique d'un generateur d'aerosol therapeutique
DE60335797D1 (de) * 2002-05-07 2011-03-03 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
US20040045546A1 (en) * 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
GB0222295D0 (en) 2002-09-25 2002-10-30 3M Innovative Properties Co Breath actuated medicament dispensing devices
US7204248B2 (en) 2002-09-27 2007-04-17 Cook Critical Care Incorporated Fiberoptic nebulizer
US20040100509A1 (en) 2002-11-27 2004-05-27 Microsoft Corporation Web page partitioning, reformatting and navigation
US7683029B2 (en) * 2003-05-07 2010-03-23 Philip Morris Usa Inc. Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
US7600512B2 (en) 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US20050030953A1 (en) 2003-08-04 2005-02-10 Subramanian Vasudevan Method of controlling reverse link transmission
US20050172958A1 (en) 2003-08-20 2005-08-11 The Brigham And Women's Hospital, Inc. Inhalation device and system for the remote monitoring of drug administration
WO2005051177A2 (en) 2003-11-25 2005-06-09 Coifman Robert E Devices for measuring inspiratory airflow
WO2005065756A2 (en) 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Dry powder nebulizers and associated methods of dispensing dry powders
US7819115B2 (en) 2004-01-30 2010-10-26 Hewlett-Packard Development Company, L.P. Inhalers and methods of controlling airflow in inhalers
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
US7063112B2 (en) * 2004-03-17 2006-06-20 Husky Corporation Fuel dispensing nozzle having a dripless spout
EP1737517B1 (en) 2004-04-02 2010-10-06 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Aerosol delivery systems
GB0408836D0 (en) 2004-04-21 2004-05-26 Univ Hull A system
WO2006042419A1 (en) 2004-10-22 2006-04-27 Multi-Vet Ltd. Mobile electronic device with fluid delivery system
WO2006062449A1 (en) 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyra AB Breath actuated dose inhaler
FR2879574B1 (fr) 2004-12-17 2011-01-21 Valois Sas Dispositif de distribution de produit fluide.
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
US7219664B2 (en) 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
WO2007035913A2 (en) 2005-09-21 2007-03-29 Kurve Technology, Inc. Medicament delivery control, monitoring, and reporting system and method
FR2892158B1 (fr) 2005-10-17 2011-10-21 Valois Sas Pompe de distribution de produit fluide
KR20080064171A (ko) 2005-10-20 2008-07-08 나스텍 파마수티컬 컴퍼니 인코포레이티드 속효성 인슐린의 비강내 투여
DE102005052898A1 (de) 2005-11-03 2007-05-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zum Dosieren von Arzneimitteln
DE102005056488A1 (de) * 2005-11-21 2007-05-24 Ing. Erich Pfeiffer Gmbh Spender und Dosierbaugruppe für die Mediumdosierung
DE602006013865D1 (de) 2005-11-21 2010-06-02 Mannkind Corp Gerät und Verfahren zur Pulverausgabe und Messung
PL1969004T3 (pl) 2005-12-28 2012-01-31 Novo Nordisk As Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
WO2007104738A2 (en) * 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
JP5004483B2 (ja) * 2006-03-15 2012-08-22 株式会社Ａｄｅｋａ プリプレグ用エポキシ樹脂硬化性組成物
US20090095292A1 (en) 2006-04-10 2009-04-16 Canon Kabushiki Kaisha Ingesta administration device
GB0610666D0 (en) * 2006-05-30 2006-07-05 Glaxo Group Ltd Fluid dispenser
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
US9208500B2 (en) 2006-07-21 2015-12-08 Microsoft Technology Licensing, Llc Fixed position multi-state interactive advertisement
CN101495168A (zh) 2006-08-01 2009-07-29 佳能株式会社 药物喷射设备
JP5207679B2 (ja) 2006-08-01 2013-06-12 キヤノン株式会社 薬剤吐出装置
US20100180890A1 (en) * 2006-09-29 2010-07-22 Canon Kabushiki Kaisha Inhaler
US20080306794A1 (en) 2006-11-27 2008-12-11 Ooggieya Ltd. Measurement of content placement effectiveness over web pages and like media
WO2008112353A2 (en) 2007-02-05 2008-09-18 The Brigham And Women's Hospital, Inc. Instrumented metered-dose inhaler and methods for predicting disease exacerbations
US20090301472A1 (en) * 2007-02-08 2009-12-10 Kim Matthew H J Aerosol delivery systems and methods
US8348107B2 (en) 2007-02-20 2013-01-08 Conagra Foods Rdm, Inc. Food dispensing apparatus
US7904062B2 (en) 2007-03-08 2011-03-08 Yahoo! Inc. Scrolling mobile advertisements
US20090241948A1 (en) * 2007-03-28 2009-10-01 Dermot Joseph Clancy Humidification in breathing circuits
JP2010532672A (ja) 2007-03-30 2010-10-14 デューク ユニバーシティ 薬剤を送給するための装置および方法
EP2152243A2 (en) 2007-04-30 2010-02-17 Novo Nordisk A/S Highly concentrated insulin solutions and compositions
US8261738B2 (en) * 2007-07-24 2012-09-11 Respironics Respiratory Drug Delivery (Uk) Ltd. Apparatus and method for maintaining consistency for aerosol drug delivery treatments
US20090151716A1 (en) 2007-09-18 2009-06-18 Robert Abrams Semi-automatic emergency medication dose nebulizer
US20090156952A1 (en) 2007-12-13 2009-06-18 Hunter C Eric Apparatuses and Methods for Diagnosing and Treating Respiratory Conditions
US20090151718A1 (en) 2007-12-13 2009-06-18 Next Safety, Inc. Apparatuses and Methods for Diagnosing and Treating Respiratory Conditions
US9550031B2 (en) 2008-02-01 2017-01-24 Reciprocal Labs Corporation Device and method to monitor, track, map, and analyze usage of metered-dose inhalers in real-time
WO2009111612A1 (en) 2008-03-07 2009-09-11 Novartis Ag Aerosolization device
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
US8578932B2 (en) 2008-07-10 2013-11-12 Bang & Olufsen Medicom A/S Inhaler and a method of operating it
DE102008054431B3 (de) * 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
US8356247B2 (en) 2008-12-16 2013-01-15 Rich Media Worldwide, Llc Content rendering control system and method
JP5180109B2 (ja) 2009-01-26 2013-04-10 株式会社エヌ・ティ・ティ・ドコモ 移動通信方法及び無線基地局
CN102388520B (zh) 2009-02-27 2015-01-21 飞兆半导体公司 外围装置主机充电
US9163883B2 (en) 2009-03-06 2015-10-20 Kevlin Thermal Technologies, Inc. Flexible thermal ground plane and manufacturing the same
NZ575836A (en) 2009-03-27 2009-08-28 Nexus6 Ltd Improvements in or Relating to Medicament Delivery Systems
US7886783B2 (en) 2009-05-22 2011-02-15 The General Electric Company Anesthetic vaporizer filling system
EP2438155B1 (en) 2009-06-04 2016-08-10 The General Hospital Corporation Bioartificial lung
US8495998B2 (en) 2009-06-17 2013-07-30 British American Tobacco (Investments) Limited Inhaler
US9395827B2 (en) 2009-07-21 2016-07-19 Qualcomm Incorporated System for detecting orientation of magnetically coupled devices
US9545488B2 (en) 2010-01-12 2017-01-17 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US8950394B2 (en) 2010-01-12 2015-02-10 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
CN102802710B (zh) 2010-01-14 2015-11-25 皇家飞利浦电子股份有限公司 利用负压支持的伺服通气
CN102711882B (zh) 2010-01-20 2014-10-29 皇家飞利浦电子股份有限公司 基于温度的气雾剂探测
US20110225008A1 (en) 2010-03-09 2011-09-15 Respira Dv, Llc Self-Similar Medical Communications System
WO2011112982A2 (en) 2010-03-12 2011-09-15 Kocks Peter F Systems and methods for organizing and displaying electronic media content
WO2011130183A2 (en) 2010-04-11 2011-10-20 Proteus Biomedical, Inc. Apparatus, system and method for detection and delivery of a medicinal dose
WO2011130583A2 (en) 2010-04-15 2011-10-20 Spectrum Health Innovations, LLC Inhaler module and related system
KR20120013727A (ko) 2010-08-06 2012-02-15 삼성전자주식회사 디스플레이장치 및 그 제어방법
WO2012022026A1 (zh) 2010-08-17 2012-02-23 富士通株式会社 一种资源分配方法、系统和发射机
US20120144303A1 (en) 2010-10-08 2012-06-07 Michael Cricks Hd website skin
TW201219010A (en) 2010-11-05 2012-05-16 Univ Nat Cheng Kung Portable asthma detection device and stand-alone portable asthma detection device
JP5487093B2 (ja) 2010-12-17 2014-05-07 三菱航空機株式会社 耐雷ファスナ、耐雷ファスナの取付構造、航空機
WO2013009346A1 (en) 2011-07-12 2013-01-17 Intel Corporation Resource scheduling for machine-to-machine devices
US8326964B1 (en) 2011-11-14 2012-12-04 Limelight Networks, Inc. Website data content access progression
GB2498569A (en) 2012-01-20 2013-07-24 Intellectual Ventures Holding 81 Llc Terminal device communicating on a narrow subset frequency contained within a main frequency band
US20130269694A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Inhaler controlled by mobile device
CA2793763C (en) 2012-05-24 2015-12-29 Research In Motion Limited Presentation of image on display screen with combination crop and rotation and with auto-resizing of crop field
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR091902A1 (es) 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
US9248246B2 (en) 2013-09-27 2016-02-02 Cellco Partnership Category 1 M2M device data transmission via a long term evolution network
US10307550B2 (en) 2014-06-09 2019-06-04 Dance Biopharm Inc. Liquid drug cartridges and associated dispenser
US10857313B2 (en) 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
US10471222B2 (en) 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
EP3261648B1 (en) 2015-02-25 2023-12-06 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564129A (en) * 1983-01-27 1986-01-14 Hoechst-Roussel Pharmaceuticals Inc. Dosage dispensing unit
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
CN1303309A (zh) * 1998-06-11 2001-07-11 艾若根公司 改进的在便携式吸入器内存储化合物的方法和设备
CN2406684Y (zh) * 1999-11-26 2000-11-22 北京亚都科技股份有限公司 医用雾化器
US20040256488A1 (en) * 2001-03-20 2004-12-23 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US20070163572A1 (en) * 2004-02-20 2007-07-19 Addington W R Intra-oral nebulizer
US20090157037A1 (en) * 2007-10-12 2009-06-18 Laxmi Iyer Inhalation drug delivery

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11833291B2 (en) 2010-01-12 2023-12-05 Aerami Therapeutics, Inc. Preservative-free single dose inhaler systems
CN105307620A (zh) * 2013-04-16 2016-02-03 当斯生物制药有限公司 液体分配和用于分配液体的方法
US10569033B2 (en) 2013-04-16 2020-02-25 Dance Biopharm Inc. Liquid dispensing and methods for dispensing liquids
CN106102808A (zh) * 2014-02-25 2016-11-09 帕里医药有限责任公司 吸入器和吸入器组
CN106102808B (zh) * 2014-02-25 2021-08-17 帕瑞制药有限公司 吸入器和吸入器组
CN112891688A (zh) * 2014-08-28 2021-06-04 诺顿（沃特福特）有限公司 吸入器的依从性辅助模块
CN110167618A (zh) * 2016-12-09 2019-08-23 微计量医疗公司 吸入器
CN111356494A (zh) * 2017-10-23 2020-06-30 耐布太克医辽产品科恩股份有限公司 喷雾器中的自动加药

Also Published As

Publication number Publication date
WO2011088070A1 (en) 2011-07-21
EP2523716A1 (en) 2012-11-21
US11400241B2 (en) 2022-08-02
ES2698401T3 (es) 2019-02-04
CN102740911B (zh) 2014-09-24
US20200078539A1 (en) 2020-03-12
AU2011205443A1 (en) 2012-09-06
MX340395B (es) 2016-07-07
BR112012017177B1 (pt) 2020-10-13
CA2786131A1 (en) 2011-07-21
US11833291B2 (en) 2023-12-05
EP2523712A4 (en) 2013-08-14
BR112012017176A2 (pt) 2018-07-31
MX344439B (es) 2016-12-15
EP2523716A4 (en) 2015-09-02
AU2011205443B2 (en) 2015-09-24
BR112012017176B1 (pt) 2022-01-04
US20180353714A1 (en) 2018-12-13
RU2548755C2 (ru) 2015-04-20
US20110168172A1 (en) 2011-07-14
US10076613B2 (en) 2018-09-18
US9004061B2 (en) 2015-04-14
CA2786128C (en) 2018-04-17
KR101828426B1 (ko) 2018-02-12
US10744282B2 (en) 2020-08-18
CA2786131C (en) 2019-04-16
RU2012134402A (ru) 2014-02-20
KR20120125494A (ko) 2012-11-15
EP2523712A1 (en) 2012-11-21
US20160271346A1 (en) 2016-09-22
US20140041653A1 (en) 2014-02-13
MX2012008010A (es) 2012-10-03
MX2012008011A (es) 2012-10-03
AU2011205444A1 (en) 2012-09-06
US20230051645A1 (en) 2023-02-16
CN102740915B (zh) 2016-01-20
US10525214B2 (en) 2020-01-07
US9180261B2 (en) 2015-11-10
US20110168170A1 (en) 2011-07-14
AU2011205444B2 (en) 2015-06-18
RU2012134422A (ru) 2014-02-20
EP2523716B1 (en) 2020-11-11
US20160129088A1 (en) 2016-05-12
CN102740911A (zh) 2012-10-17
EP2523712B1 (en) 2018-08-22
RU2559171C2 (ru) 2015-08-10
KR20120115389A (ko) 2012-10-17
US8950394B2 (en) 2015-02-10
WO2011088071A1 (en) 2011-07-21
CA2786128A1 (en) 2011-07-21
BR112012017177A2 (pt) 2018-07-31

Similar Documents

Publication Publication Date Title
CN102740915B (zh) 无防腐剂的单剂量吸入器系统
US11786676B2 (en) Methods and systems for supplying aerosolization devices with liquid medicaments
AU670342B2 (en) Dispensing apparatus
AU764814B2 (en) Pulmonary aerosol delivery device and method
US9545488B2 (en) Preservative-free single dose inhaler systems
CN105307620B (zh) 液体分配和用于分配液体的方法
JPH10508251A (ja) 液体分配装置および方法
JP2005530535A (ja) ノズル及びその固定手段を含むシステム
WO2011015850A1 (en) Medical aerosol apparatus
TW201226004A (en) Medicine conveyance device
KR20010099950A (ko) 허파용 에어로졸 공급 장치 및 방법

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP03 Change of name, title or address

Address after: American California

Patentee after: Dance leap biopharmaceutical Co., Ltd.

Address before: American California

Patentee before: Dance Pharmaceuticals Inc.

CP01 Change in the name or title of a patent holder

Address after: American California

Patentee after: Chinese Dance biopharmaceutical company

Address before: American California

Patentee before: Dance leap biopharmaceutical Co., Ltd.

CP01 Change in the name or title of a patent holder