CN102698196B - Decoction for treating cholestasis of pregnancy - Google Patents
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Abstract
The invention discloses decoction for treating the cholestasis of pregnancy. The decoction is prepared by the following materials in parts by weight: 10-30 parts of oriental wormwood, 10-15 parts of cape jasmine fruit, 10-15 parts of radix bupleuri, 10-15 parts of radix curcumae, 10-30 parts of honeysuckle, 10-30 parts of desmodium, 10-20 parts of roasted radix scutellariae, 10-20 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of poria cocos, 10-20 parts of rhizoma dioscoreae, 10-15 parts of schisandra chinensis and a proper amount of water. The decoction disclosed by the invention has the effects of fading yellow, relieving itching, soothing liver and gallbladder, warming spleen and dispelling cold, dissipating dampness and activating collaterals, soothing liver and tonifying spleen and promoting circulation and removing stasis, is safe and effective, is fast in effect and is convenient to carry.
Description
Technical field
The present invention relates to the field of Chinese medicines, is exactly a kind of decoction for the treatment of cholestasis of pregnancy disease.
Background technology
Trimester of pregnancy Intrahepatic Cholestasis (Interahepatic Cholestasis of Pregancy, hereinafter to be referred as ICP) be a kind of trimester of pregnancy idiopathic disease, often show as clinically skin pruritus or jaundice, increase with serum tolal bile acid simultaneously, some patients were is also seen abnormal liver function, and especially alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkali phosphatase (ALP), bilirubin (TBIL) etc. is abnormal.And afterwards when gestation the tendency of recurrence is arranged, be one of important complication of obstetrics.Primary disease all has harm to female youngster, and it can cause fetal distress in uterus, growth retardation, oligohydramnios, premature labor, asphyxia of newborn, postpartum hemorrhage, and serious caused stillborn fetus, stillbirth are one of reasons of enclosing died.In recent years, its sickness rate has the trend that rises gradually,, because the cause of disease is also fully not clear at present, lacks effective medicine and means, adopts still Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs primary disease, receives comparatively satisfied effect.
Trimester of pregnancy, Intrahepatic Cholestasis pruritus and jaundice occurred as characteristics take trimester of pregnancy, and early productive rate and perinatal mortality rate are high, and its morbidity has substantial connection with estrogen, now causes widely clinical attention.Clinical manifestation is that pruritus appears in pregnant middle and advanced stage, or pruritus and jaundice coexist simultaneously, and a minute puerperium rapidly disappears.Impact on pregnant prognosis mainly contains: premature labor, fetal distress, postpartum hemorrhage, obstetric complication etc.
Primary disease belongs to the traditional Chinese medical science " jaundice ", " son yellow " category, and what the traditional Chinese medical science was thought primary disease occurs as the diseases caused by exogenous pathogenic factor seasonal pathogen, and is strongly fragrant and do not reach, so that the retention of damp-heat in the interior taste, the heat that with the passing of time seems is and beneficial dark, and heat is because of the wet Sheng that heals, damp and hot fumigating in liver and gall, cause bile and leak, and invades skin generation jaundice; Also can be because food and drink does not save impairing the spleen and stomach, thus transportation capabilities are not normal, endogenous damp formation, strongly fragrant heat-transformation of a specified duration, damp and hot friendship is steamed and is jaundice; Also can be excessive because of impairment caused by overstrain, or plain body deficiency-weakness of spleen-QI, cause hypoactivity of YANG in middle-JIAO, dysfunction of the spleen in transportation and transformation, stagnation of cold-damp, send out as YIN jaundice; Or because of the YANG jaundice delay, lose and control, yang-energy is impaired, hypoactivity of spleen-YANG, and internal retention of cold wetness, also can transfer YIN jaundice to.Ancient medicine is thought, disharmony between QI and blood, and qi depression to blood stasis, damp and hot suffocating of liver and gall, stagnation of blood stasis and heat are the essence place of primary disease.Therefore the main pathology of intrahepatic cholestasis of pregnancy is damp and hot, the stagnation of QI, blood stasis.TCM Clinical should be for different patients' various diseases, and which is more important to distinguish it, and a minute another matter is controlled, the satisfaction of often producing effects.
Summary of the invention
The purpose of this invention is to provide a kind of take off yellow antipruritic, instant effect, and the decoction of portable treatment cholestasis of pregnancy disease.
The present invention adopts following technical scheme:
A kind of decoction for the treatment of cholestasis of pregnancy disease, it is characterized in that, it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 10 – 30, Fructus Gardeniae 10 – 15, Radix Bupleuri 10 – 15, Radix Curcumae 10 – 15, Flos Lonicerae 10 – 30, Herba Lysimachiae 10 – 30, Radix Scutellariae (parched) 10 – 20, Rhizoma Atractylodis Macrocephalae (parched) 10 – 20, Poria 10 – 20, Rhizoma Dioscoreae 10 – 20, Fructus Schisandrae Chinensis 10 – 15, water is appropriate.
A kind of decoction for the treatment of cholestasis of pregnancy disease, it is characterized in that, it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 18 – 22, Fructus Gardeniae 10 – 12, Radix Bupleuri 11 – 13, Radix Curcumae 11 – 13, Flos Lonicerae 18-22, Herba Lysimachiae 18 – 22, Radix Scutellariae (parched) 14-16, Rhizoma Atractylodis Macrocephalae (parched) 14 – 16, Poria 14 – 16, Rhizoma Dioscoreae 14 – 16, Fructus Schisandrae Chinensis 11 – 13, water is appropriate.
The decoction of described treatment cholestasis of pregnancy disease, it is characterized in that: it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 20, Fructus Gardeniae 12, Radix Bupleuri 12, Radix Curcumae 12, Flos Lonicerae 20, Herba Lysimachiae 20, Radix Scutellariae (parched) 15, Rhizoma Atractylodis Macrocephalae (parched) 15, Poria 15, Rhizoma Dioscoreae 15, Fructus Schisandrae Chinensis 12, water is appropriate.
The decoction of described treatment cholestasis of pregnancy disease, it is characterized in that: preparation method is: get by weight each crude drug and clean up rear mix homogeneously, every gross weight is the water soaking 2-3 hour that the raw material mixing medicine of 1 kilogram of left and right is used 4 liters of left and right at ambient temperature, then decoct about 1 hour, pack after routine removes slag filtration and get final product, every bag of 100ml left and right.
The present invention can on former basic side's basis, add and subtract with disease.Liver gallbladder damp-heat type adds Herba Sedi, the Radix Rehmanniae, Folium Bambusae, Cortex Moutan etc. partially; The deficiency of spleen and stomach type adds Radix Dipsaci, the Cortex Eucommiae, Fructus Psoraleae, Herba Epimedii, Rhizoma Zingiberis etc. partially; Cold-dampness type adds the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, Pericarpium Citri Reticulatae, Rhizoma Cyperi, seed of Job's tears etc. partially; Qi-stagnation type adds Rhizoma Cyperi, flower bud of Japanese apricot, Radix Glycyrrhizae etc. partially; The heat clearing and damp drying such as very adding the Fructus Kochiae, Radix Cynanchi Paniculati, favus skin of itching is antipruritic.
Using method: 3 times/days, each one bag, taking medicine after meal.Two weeks were a course for the treatment of, general recovery from illness 1-3 the course for the treatment of.
Beneficial effect of the present invention is:
1, the present invention accepts clinic case 120 examples for medical treatment, and total effective rate reaches 90%;
2, the present invention has the effect that takes off yellow antipruritic, depressed liver-energy dispersing and function of gallbladder promoting, warming the spleen cold expelling, removing dampness and network, the liver soothing and the spleen invigorating, blood circulation promoting and blood stasis dispelling, safety, effectively, instant effect, and be easy to carry.
The specific embodiment
The decoction of described treatment cholestasis of pregnancy disease, it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 20, Fructus Gardeniae 12, Radix Bupleuri 12, Radix Curcumae 12, Flos Lonicerae 20, Herba Lysimachiae 20, Radix Scutellariae (parched) 15, Rhizoma Atractylodis Macrocephalae (parched) 15, Poria 15, Rhizoma Dioscoreae 15, Fructus Schisandrae Chinensis 12, water is appropriate.
Preparation method is: get by weight each crude drug and clean up rear mix homogeneously, every gross weight is that the raw material mixing medicine of 1 kilogram is used the water soaking 2 hours of 4 liters at ambient temperature, then decocts 1 hour, through routine remove slag filter after pack and get final product every bag of 100ml.
Using method: 3 times/days, each one bag, taking medicine after meal.Two weeks were a course for the treatment of, general recovery from illness 1-3 the course for the treatment of.
Model case:
Case one: Wang, female, 27 years old, office worker.The first visit date: on April 20th, 2009
Pregnant 27 weeks of patient went to a doctor because of skin pruritus in 3 days, and a corpse or other object for laboratory examination and chemical testing: patient's abdominal part and extremity skin have obvious scratch, and the patient tells skin pruritus, can not sleep peacefully, and companion's urine yellow skin, xerostomia is irritated, red tongue thin fur, stringy and rolling pulse.Blood is looked into TOTAL BILE ACID TBA, and to reach the 23.6umol/L(normal value be 0 – 10 umol/L), it is 0 – 42 U/L that glutamate pyruvate transaminase reaches 160 U/L(normal values), glutamate-oxaloacetate transaminase 80 U/L(normal values are 0 – 42 U/L), other numerical value of liver function are all in normal range.Be diagnosed as cholestasis of pregnancy disease.Give the present embodiment.After taking a week, the patient feels skin pruritus and is clearly better, and checks TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT all in normal range after continuing to take January.
Case two: Lee, female, 24 years old, peasant.The first visit date: on July 18th, 2008
Pregnant 32 weeks of patient are medical because of one week of skin pruritus, and a corpse or other object for laboratory examination and chemical testing: the patient tells the whole skin pruritus, can not sleep peacefully, and the skin of abdomen pruritus is more obvious, with constipation, and yellowish urine, xerostomia is irritated, red tongue with thin and yellow fur, stringy and rolling pulse number.Blood is looked into TOTAL BILE ACID TBA, and to reach the 32.7umol/L(normal value be 0 – 10 umol/L), it is 0 – 42 U/L that glutamate pyruvate transaminase reaches 320 U/L(normal values), glutamic oxaloacetic transaminase, GOT 370 U/L(normal values are 0 – 42 U/L), other numerical value of liver function are all in normal range.Be diagnosed as cholestasis of pregnancy disease.Give the present embodiment, after taking a week, the patient feels the whole skin pruritus and is clearly better, and continues to take after first quarter moon to check TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT numerical value and all descend to some extent, and rear patient row in advance cuts open palace and gives birth to boy baby's survival.
Case three: Shen, female, 22 years old, teacher.The first visit date: on January 10th, 2011
Pregnant 24 weeks of patient went to a doctor because of skin pruritus in 1 day, and a corpse or other object for laboratory examination and chemical testing: patient's skin of abdomen has obvious scratch, and the patient tells and felt the skin of abdomen pruritus yesterday at night, and the urine yellow skin, have burning sensation within the next few days, and companion's xerostomia is irritated, red tongue with thin fur, stringy and rolling pulse.Blood is looked into TOTAL BILE ACID TBA, and to reach the 16.8umol/L(normal value be 0 – 10 umol/L), it is 0 – 42 U/L that glutamate pyruvate transaminase reaches 95 U/L(normal values), glutamate-oxaloacetate transaminase 05U/L(normal value is 0 – 42 U/L), other numerical value of liver function are all in normal range.Be diagnosed as cholestasis of pregnancy disease.Give the present embodiment, after taking a week, the patient feels skin pruritus and disappears, and check TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT numerical value all descend to some extent, checks TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT all in normal range after continuing to take first quarter moon.
Case four: the summer, the female, 29 years old, unemployed.The first visit date: on November 7th, 2010
Pregnant 30 weeks of patient went to a doctor because of skin pruritus in 5 days, and a corpse or other object for laboratory examination and chemical testing: the patient tells abdominal part and extremity skin pruritus, and two lower limb prurituss are obvious, and the urine yellow skin, have burning sensation within the next few days, companion's xerostomia, red tongue with thin fur, stringy and rolling pulse.Blood is looked into TOTAL BILE ACID TBA, and to reach the 17.5umol/L(normal value be 0 – 10 umol/L), it is 0 – 42 U/L that glutamate pyruvate transaminase reaches the 115U/L(normal value), glutamic oxaloacetic transaminase, GOT 95U/L(normal value is 0 – 42 U/L), other numerical value of liver function are all in normal range.Be diagnosed as cholestasis of pregnancy disease.Give the present embodiment, after taking a week, the patient feels skin pruritus and is clearly better, and checks TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT all in normal range after continuing to take January.
Case five: Jiang, female, 21 years old, office worker.The first visit date: on July 10th, 2011
Pregnant 35 weeks of patient go to a doctor more than the skin pruritus first quarter moon, a corpse or other object for laboratory examination and chemical testing: patient's abdominal part and extremity skin have obvious scratch, and the patient tells the whole skin pruritus unbearably, and sleep night and feel unwell, constipation, yellowish urine, xerostomia is irritated, red tongue with yellow fur, slippery and rapid pulse.Blood is looked into TOTAL BILE ACID TBA, and to reach the 27.8umol/L(normal value be 0 – 10 umol/L), it is 0 – 42 U/L that glutamate pyruvate transaminase reaches 630 U/L(normal values), glutamic oxaloacetic transaminase, GOT 780U/L(normal value is 0 – 42 U/L), other numerical value of liver function are all in normal range.Color ultrasound is shown: evening is pregnant, the placenta ripening degree
Level, fetus is less than normal.Be diagnosed as cholestasis of pregnancy disease.Give the present embodiment, after taking a week, the patient feels skin pruritus and takes a turn for the better, and check TOTAL BILE ACID TBA, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT numerical value all descend to some extent.The patient is the row cesarean section during pregnant 37 week, gives birth to girl baby's body strong.
Claims (3)
1. decoction for the treatment of cholestasis of pregnancy disease, it is characterized in that, it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 10 – 30, Fructus Gardeniae 10 – 15, Radix Bupleuri 10 – 15, Radix Curcumae 10 – 15, Flos Lonicerae 10 – 30, Herba Lysimachiae 10 – 30, Radix Scutellariae (parched) 10 – 20, Rhizoma Atractylodis Macrocephalae (parched) 10 – 20, Poria 10 – 20, Rhizoma Dioscoreae 10 – 20, Fructus Schisandrae Chinensis 10 – 15, and water is appropriate;
The decoction of described treatment cholestasis of pregnancy disease, preparation method is: get by weight each crude drug and clean up rear mix homogeneously, every gross weight is that the raw material mixing medicine of 1 kilogram is used the water soaking 2-3 hour of 4 liters at ambient temperature, then decoct one hour, pack after routine removes slag filtration and get final product every bag of 100ml.
2. decoction for the treatment of cholestasis of pregnancy disease, it is characterized in that, it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 18 – 22, Fructus Gardeniae 10 – 12, Radix Bupleuri 11 – 13, Radix Curcumae 11 – 13, Flos Lonicerae 18-22, Herba Lysimachiae 18 – 22, Radix Scutellariae (parched) 14-16, Rhizoma Atractylodis Macrocephalae (parched) 14 – 16, Poria 14 – 16, Rhizoma Dioscoreae 14 – 16, Fructus Schisandrae Chinensis 11 – 13, water is appropriate.
3. the decoction for the treatment of cholestasis of pregnancy disease according to claim 1, it is characterized in that: it is to be made by the crude drug of following weight portion: Herba Artemisiae Scopariae 20, Fructus Gardeniae 12, Radix Bupleuri 12, Radix Curcumae 12, Flos Lonicerae 20, Herba Lysimachiae 20, Radix Scutellariae (parched) 15, Rhizoma Atractylodis Macrocephalae (parched) 15, Poria 15, Rhizoma Dioscoreae 15, Fructus Schisandrae Chinensis 12, water is appropriate.
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| CN104288691A (en) * | 2014-10-20 | 2015-01-21 | 济南高达信息技术有限公司 | Traditional Chinese medicine decoction for treating cholestasis syndrome |
| CN105878786B (en) * | 2014-12-10 | 2019-03-22 | 江南大学 | It is a kind of for treating the Chinese medicine composition of intrahepatic cholestasis of pregnancy |
| CN104721786A (en) * | 2015-03-11 | 2015-06-24 | 张祥华 | Traditional Chinese medicine preparation for treating intrahepatic cholestasis of pregnancy and preparation method of traditional Chinese medicine preparation |
| CN106361766A (en) * | 2016-11-01 | 2017-02-01 | 侯建生 | Application of ozonized oil in prevention and treatment of pregnancy diseases |
| CN108477569A (en) * | 2018-02-27 | 2018-09-04 | 成金焕 | Prevent amniotic fluid and reduces or need to increase diet therapy soup of amniotic fluid and preparation method thereof and drinking method |
| CN113577191A (en) * | 2021-08-25 | 2021-11-02 | 丽水市中医院 | Traditional Chinese medicine formula for preventing neonatal pathologic jaundice in pregnancy and preparation and using methods thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1053110C (en) * | 1995-07-12 | 2000-06-07 | 陈瑛 | Prescription of Chinese medicine for treating cholecystitis, cholelithiasis, hepatitis and cholehepatocirrhosis |
| CN101129983A (en) * | 2007-08-21 | 2008-02-27 | 王军 | Chaihuang Qingdan Wan (Chaihuang Bolus for clearing gallbladder) |
| CN101537159B (en) * | 2009-04-29 | 2011-02-02 | 赵翠英 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN102058736A (en) * | 2009-11-11 | 2011-05-18 | 董根荣 | Medicament for preventing and treating blood group incompatible hemolytic disease during pregnancy and preparation method thereof |
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Effective date of registration: 20221229 Address after: No. 33, Kunming Road, Linyi Economic Development Zone, Shandong 276000 Patentee after: Linyi Ruiganglian Pipe Industry Co.,Ltd. Address before: 238200 Department of Gynecology, traditional Chinese medicine hospital, No. 135, Liyang Middle Road, he County, Ma'anshan City, Anhui Province Patentee before: Zhang Chunmin |
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