CN102697954B - White peony root Chinese medicinal preparation for treating headache and preparation method thereof - Google Patents
White peony root Chinese medicinal preparation for treating headache and preparation method thereof Download PDFInfo
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Abstract
本发明公开了一种治疗头痛白芍中药制剂，由以下重量份的中药原料制成：熟地黄200-400份、川芎200-300份、当归200-300份、白芍150-250份、川红花50-150份、高丽参50-150份，诸药共奏补养阴血之功，本发明的中药制剂对内伤头痛血虚型患者有显著治疗效果，可迅速缓解头痛且晕，午后较甚，神疲乏力，心悸，面色少华的症状，本制剂无毒副作用，治疗效果显著，从根本上解除了患者的痛苦。The invention discloses a white peony root Chinese medicine preparation for treating headache. The preparation is prepared from the following Chinese medicine raw materials in parts by weight: 200-400 parts of prepared rehmannia root, 200-300 parts of chuanxiong, 200-300 parts of angelica, 150-250 parts of white peony root, 50-150 parts of safflower and 50-150 parts of Korean ginseng. All the medicines work together to nourish yin and blood. The Chinese medicine preparation has a significant therapeutic effect on patients with internal injury headache and blood deficiency type, can quickly relieve headache and dizziness, which is more severe in the afternoon, fatigue, palpitations and pale complexion, has no toxic side effects, has a significant therapeutic effect and fundamentally relieves the pain of patients.
Description
技术领域 technical field
本发明属于中药领域，尤其涉及一种用于治疗头痛白芍中药制剂及制备方法。The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal preparation of Radix Paeoniae Alba for treating headaches and a preparation method thereof.
背景技术 Background technique
内伤不足先天禀赋不足，或劳欲伤肾，阴精耗损，或年老气血衰败，或久病不愈，产后、失血之后，营血亏损，气血不能上营于脑，髓海不充则可致头痛，此外，外伤跌扑，或久病人络则络行不畅，血瘀气滞，脉络失养而易致头痛。头为神明之府，“诸阳之会”，“脑为髓海”，五脏精华之血，六腑清阳之气皆能上注于头，即头与五脏六腑之阴精、阳气密切相关，凡能影响脏腑之精血、阳气的因素皆可成为头痛的病因，归纳起来不外外感与内伤两类。病位虽在头，但与肝脾肾密切相关，风、火、痰、瘀、虚为致病之主要因素，邪阻脉络，清窍不利；精血不足，脑失所养，为头痛之基本病机。中医判断头痛病分外感和内伤两大类，一般外感头痛，为时短暂，多由风邪为主，必须分清主次，明辨标本，施治方可中的，内伤头痛，以补虚扶正为先；本虚标实者，或先以治标，继则扶正，或标本兼顾，当因证制宜。西药治疗药费高，副作用大，还容易复发。采用中医中药的手段来治疗头痛疾病，标本兼顾，是一极待开发的渠道，适用范围广，治疗方面有其独到的效果。Insufficient internal injury, lack of congenital endowment, or fatigue damages the kidneys, depletion of yin essence, or decline of qi and blood in old age, or prolonged illness, postpartum, after blood loss, nutrient and blood loss, qi and blood cannot enter the brain, and the marrow sea is not full Then it can cause headaches. In addition, traumatic falls, or chronically ill patients will have poor circulation of the collaterals, blood stasis and qi stagnation, and loss of nourishment of the veins will easily cause headaches. The head is the home of the gods, the "meeting of all yang", "the brain is the sea of marrow", the blood of the five viscera essence, and the clear yang qi of the six fu organs can all be injected into the head, that is, the head is closely related to the yin essence and yang qi of the five viscera and six fu organs , all factors that can affect the essence, blood and yang energy of the viscera can become the cause of headache, which can be summed up in two categories: exogenous pathogenesis and internal injury. Although the location of the disease is in the head, it is closely related to the liver, spleen and kidney. Wind, fire, phlegm, blood stasis, and deficiency are the main factors causing the disease. pathogenesis. Traditional Chinese medicine judges headache diseases into two categories: exogenous and internal injuries. Generally, exogenous headaches are short-lived and mostly caused by wind pathogens. It is necessary to distinguish the primary from the secondary and distinguish the symptoms. For those who are deficiency in the root and excess in the superficiality, or treat the symptoms first, then strengthen the body, or take into account both the symptoms and the root causes, and adjust measures according to the evidence. The cost of Western medicine is high, the side effects are large, and it is easy to relapse. Using traditional Chinese medicine to treat headache diseases, taking both specimens and specimens into consideration, is a channel waiting to be developed, with a wide range of applications and unique effects in treatment.
发明内容 Contents of the invention
本发明的目的就是为了克服已有技术的上述缺陷，提供一种具有配伍完善，无毒副作用，疗效可靠的治疗头痛白芍中药制剂及制备方法。The purpose of the present invention is to overcome the above-mentioned defects of the prior art, and provide a traditional Chinese medicine preparation of Radix Paeoniae Alba for treating headache with perfect compatibility, no toxic and side effects, and reliable curative effect and its preparation method.
为实现上述目的，本发明是通过以下技术方案实现的：To achieve the above object, the present invention is achieved through the following technical solutions:
治疗头痛白芍中药制剂，由以下重量份的中药原料制成：The Radix Paeoniae Alba Chinese medicine preparation for treating headache is made from the following Chinese medicine raw materials in parts by weight:
熟地黄200-400份、川芎200-300份、当归200-300份、白芍150-250份、川红花50-150份、高丽参50-150份。Rehmannia glutinosa 200-400 parts, Rhizoma Chuanxiong 200-300 parts, Angelica sinensis 200-300 parts, Paeoniae Alba 150-250 parts, Sichuan safflower 50-150 parts, Korean ginseng 50-150 parts.
所述的治疗头痛白芍中药制剂，由以下重量份的中药原料制成：The described Radix Paeoniae Alba Chinese medicine preparation for treating headache is made from the following Chinese medicine raw materials in parts by weight:
熟地黄300份、川芎250份、当归250份、白芍200份、川红花100份、高丽参100份。Rehmannia glutinosa 300 parts, Rhizoma Chuanxiong 250 parts, Angelica sinensis 250 parts, Paeoniae Alba 200 parts, Sichuan safflower 100 parts, Korean ginseng 100 parts.
所述的治疗头痛白芍中药制剂的制备方法，其制备方法为：The preparation method of described Radix Paeoniae Alba Chinese medicine preparation for the treatment of headache, its preparation method is:
按比例称取上述中药原料熟地黄300份、川芎250份、当归250份、白芍200份、川红花100份、高丽参100份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Weigh 300 parts of Rehmannia glutinosa, 250 parts of Rhizoma Chuanxiong, 250 parts of Angelica sinensis, 200 parts of Radix Paeoniae Alba, 100 parts of Chuanhonghua, and 100 parts of Korean ginseng in proportion, wash and dry, crush into granules, soak in water for 1.5 hours, and then Add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then simmer for 1-2 hours, take the decoction, filter, add water 6 times the amount of raw material medicine for the second time , decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
用法与用量：口服本发明中药制剂，每次180ml，每日2次，饭后半小时，1周为1个疗程。Usage and dosage: take the traditional Chinese medicine preparation of the present invention orally, 180ml each time, twice a day, half an hour after meals, and one week is a course of treatment.
本发明原料药的药理作用如下，熟地黄：甘，微温，归肝、肾经，养血滋阴、补精益髓；川芎：辛、温，归肝、胆、心包经，活血行气、祛风止痛；当归：甘、辛、温，归肝、心、脾经，活血止痛、补血调经、润肠通便；白芍：苦、酸，微寒，归肝、脾经，养血敛阴、柔肝止痛、平抑肝阳；川红花：辛、温，归心、肝经，活血通经、祛瘀止痛、通利血脉；高丽参：甘、微苦、温，归脾、肺、心经，大补元气、复脉固脱、益气摄血；诸药共奏补养阴血之功，本发明的中药制剂对内伤头痛血虚型患者有显著治疗效果，可迅速缓解头痛且晕，午后较甚，神疲乏力，心悸，面色少华的症状，本制剂无毒副作用，治疗效果显著，从根本上解除了患者的痛苦。The pharmacological action of crude drug of the present invention is as follows, Rehmannia glutinosa: sweet, slightly warm, returns liver, kidney meridian, nourishes blood and nourishes yin, nourishes essence and marrow; Wind relieves pain; Angelica: sweet, pungent, warm, returns to liver, heart, spleen meridian, promotes blood circulation to relieve pain, nourishes blood and regulates menstruation, moistens bowel and laxative; white peony root: bitter, sour, slightly cold, returns to liver, spleen meridian, nourishes blood and restrains yin , soothing the liver, relieving pain, calming liver yang; Sichuan safflower: pungent, warm, returning to the heart, liver meridian, promoting blood circulation, removing blood stasis, relieving pain, and promoting blood vessels; Korean ginseng: sweet, slightly bitter, warm, returning to the spleen, lung, and heart meridian , invigorate vital energy, rejuvenate the veins and remove them, replenish qi and absorb blood; all the medicines play the role of nourishing yin and blood. The traditional Chinese medicine preparation of the present invention has a significant therapeutic effect on patients with internal injuries, headaches and blood deficiency, and can quickly relieve headaches and dizziness. What's more, the symptoms of mental fatigue, palpitations, and pale complexion, this preparation has no toxic and side effects, and the treatment effect is remarkable, which fundamentally relieves the suffering of the patient.
具体实施方式Detailed ways
实施例l：Embodiment 1:
中药原料：熟地黄300份、川芎250份、当归150份、白芍200份、川红花100份、高丽参100份。Chinese medicine raw materials: 300 parts of rehmannia glutinosa, 250 parts of Chuanxiong, 150 parts of angelica, 200 parts of white peony, 100 parts of Sichuan safflower, 100 parts of Korean ginseng.
制备方法：按比例称取上述中药原料熟地黄300份、川芎250份、当归250份、白芍200份、川红花100份、高丽参100份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 300 parts of Rehmannia glutinosa, 250 parts of Rhizoma Chuanxiong, 250 parts of Angelica sinensis, 200 parts of Radix Paeoniae Alba, 100 parts of Sichuan safflower, and 100 parts of Korean ginseng in proportion, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take the decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例2Example 2
中药原料：熟地黄400份、川芎300份、当归300份、白芍250份、川红花150份、高丽参150份。Chinese medicine raw materials: 400 parts of rehmannia glutinosa, 300 parts of Chuanxiong, 300 parts of angelica, 250 parts of white peony, 150 parts of Sichuan safflower, and 150 parts of Korean ginseng.
制备方法：按比例称取上述中药原料熟地黄400份、川芎300份、当归300份、白芍250份、川红花150份、高丽参150份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 400 parts of Rehmannia glutinosa, 300 parts of Rhizoma Chuanxiong, 300 parts of Angelica sinensis, 250 parts of Radix Paeoniae Alba, 150 parts of Sichuan safflower, and 150 parts of Korean ginseng in proportion, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例3：Example 3:
中药原料：熟地黄200份、川芎200份、当归200份、白芍150份、川红花50份、高丽参50份。Chinese medicine raw materials: 200 parts of rehmannia glutinosa, 200 parts of Chuanxiong, 200 parts of angelica, 150 parts of white peony, 50 parts of Sichuan safflower, and 50 parts of Korean ginseng.
制备方法：按比例称取上述中药原料熟地黄200份、川芎200份、当归200份、白芍150份、川红花50份、高丽参50份，清洗晾干，粉碎成颗粒，加水浸泡1.5小时，然后加水煎煮两次，第一次加原料药8倍量的水，武火煎沸后，再文火煎煮1-2小时，取煎液、滤过，第二次加原料药6倍量的水，煎煮0.5-1.5小时，取两次煎液，滤过，热封袋中，每袋180ml，高温灭菌，包装即得。Preparation method: Weigh 200 parts of Rehmannia glutinosa, 200 parts of Rhizoma Chuanxiong, 200 parts of Angelica sinensis, 150 parts of Radix Paeoniae Alba, 50 parts of Chuanhonghua, and 50 parts of Korean ginseng in proportion, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例4：Example 4:
临床试验Clinical Trials
1）一般资料：1) General Information:
采用本发明中药制剂共治疗37例患者，其中男12例，女25例；年龄最大者78岁，年龄最小者16岁。Adopt Chinese medicinal preparation of the present invention to treat 37 patients altogether, wherein 12 are males, 25 are females; the oldest is 78 years old, and the youngest is 16 years old.
2）诊断标准：主症：头痛且晕，午后较甚，神疲乏力，心悸，面色少华，舌淡，脉细。2) Diagnostic criteria: main symptoms: headache and dizziness, worse in the afternoon, fatigue, palpitations, pale complexion, pale tongue, thready pulse.
3）治疗方法：口服本发明实施例1中药汤剂，每次180ml，每日2次，饭后半小时，1周为1个疗程。3) Treatment method: Orally take the traditional Chinese medicine decoction of Example 1 of the present invention, 180ml each time, twice a day, half an hour after meals, and one week is a course of treatment.
4）疗效评价标准：4) Evaluation criteria for curative effect:
基本恢复：头痛消失，体征及症状完全改善，心情舒畅，精神焕发。Basic recovery: the headache disappeared, the signs and symptoms were completely improved, the mood was comfortable, and the spirit was refreshed.
显效：头痛基本消失，体征及症状显著改善，心情舒畅，精神很好。Significantly effective: the headache basically disappeared, the signs and symptoms were significantly improved, the mood was comfortable, and the spirit was very good.
有效：头痛改善，体征及症状有改变，偶感稍有不适，但能接受。Effective: The headache improved, the signs and symptoms changed, and I occasionally felt a little discomfort, but it was acceptable.
无效：体征无改变，症状如前。Ineffective: no change in signs, symptoms as before.
5）治疗结果：患者37例病例中，经两周治疗，其中基本恢复28例，显效5例，有效2例，无效2例，总有效率达94.5％。5) Treatment results: Among the 37 patients, after two weeks of treatment, 28 cases were basically recovered, 5 cases were markedly effective, 2 cases were effective, and 2 cases were ineffective, with a total effective rate of 94.5%.
实施例5：Example 5:
典型病例：余某，16岁，女，头痛且晕，午后较甚，神疲乏力，心悸，面色少华，舌淡，脉细，服用实施例1的中药制剂1周见效，2周基本恢复。Typical case: Yu Mou, 16 years old, female, headache and dizziness, worse in the afternoon, fatigue, palpitations, pale complexion, pale tongue, thready pulse, took the traditional Chinese medicine preparation of Example 1 for 1 week, and basically recovered in 2 weeks .
实施例6：Embodiment 6:
典型病例：张某，78岁，男，头痛且晕，午后较甚，神疲乏力，心悸，面色少华，舌淡，脉细，服用实施例1的中药制剂1周见效，2周基本恢复。Typical case: Zhang, 78 years old, male, headache and dizziness, more severe in the afternoon, fatigue, palpitations, pale complexion, pale tongue, thready pulse, took the traditional Chinese medicine preparation of Example 1 for 1 week and basically recovered in 2 weeks .
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| CN1843474A (en) * | 2006-02-21 | 2006-10-11 | 杨松明 | Medicine composition and method for the production thereof |
| CN102188535A (en) * | 2010-03-10 | 2011-09-21 | 胡清文 | Chinese medicine preparation for nourishing blood and promoting blood circulation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1843474A (en) * | 2006-02-21 | 2006-10-11 | 杨松明 | Medicine composition and method for the production thereof |
| CN102188535A (en) * | 2010-03-10 | 2011-09-21 | 胡清文 | Chinese medicine preparation for nourishing blood and promoting blood circulation and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 当归丸治疗功能性头疼;高一心;《山东医药工业》;20011231;第20卷(第4期);第43-44页 * |
| 高一心.当归丸治疗功能性头疼.《山东医药工业》.2001,第20卷(第4期),第43-44页. |
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