CN102671150B

CN102671150B - Medicament for treating cerebral thrombosis and preparation method thereof

Info

Publication number: CN102671150B
Application number: CN201210188474.4A
Authority: CN
Inventors: 冯远华
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-06-11
Filing date: 2012-06-11
Publication date: 2014-03-12
Anticipated expiration: 2032-06-11
Also published as: CN102671150A

Abstract

The invention discloses a medicament for treating cerebral thrombosis and a preparation method thereof. The medicament is prepared from Chinese thorowax root, turmeric root-tuber, red-rooted salvia root, notoginseng root, medicinal cyathula root, oriental waterplantain rhizome, tall gastrodia tuber and stiff silkworm; the medicament is prepared into any oral formulation; and the medicament has the effects of calming liver wind and arresting convulsion, relaxing the mind and soothing the nerves, and is used for treating cerebral thrombosis, quick in response, good in curative effect and high in cure rate.

Description

A kind of medicine for the treatment of cerebral thrombosis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of cerebral thrombosis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Cerebral thrombosis is a kind of of ischemic cerebrovascular, is that the pathological changes due to cerebrovascular wall itself causes.The general onset of cerebral thrombosis is slower, in the sleep of being everlasting or occur during quiet rest.The common cause of disease of cerebral thrombosis is arteriosclerosis, due to cerebral arteriosclerosis, tube chamber inner membrance is coarse, tube chamber narrows down, under certain conditions, under the effect of the factors such as Blood pressure drop, slow blood flow or blood viscosity increase, Platelet enhancing, thrombin coagulation in bulk in tube chamber, form thrombosis, make vascular occlusion, blood flow interrupts, thereby makes the cerebral tissue ischemia, anoxia, softening, downright bad and fall ill in blood vessel blood supply district.Cerebral thrombus patient is mostly old, and many chronic diseases are burdened with, and have the situation of many careful medications, and doctor trained in Western medicine be take thromboembolism treatment as main in treatment, and it is main that the treatment period is sent out rescue in period mainly with disease.The long-term prescription that prevents recurrence for convalescent period, easily cause the Drug resistance of patient to medicine, and side effects is larger.

Summary of the invention

Therefore, there is great demand to the Chinese medicine of effective treatment cerebral thrombosis in people, also do not find about relevant report of the present invention up to now.

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the Chinese medicine for the treatment of cerebral thrombosis, thereby has completed the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition that can treat cerebral thrombosis.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Bupleuri, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Cyathulae, Rhizoma Alismatis, Fructus Ligustri Lucidi, Poria, Fructus Aurantii Immaturus, Flos Chrysanthemi, Spica Prunellae, Rhizoma Gastrodiae, Bombyx Batryticatus, Fructus Lycii, Radix Codonopsis, Carnis Naemorhedi, the Rhizoma Atractylodis Macrocephalae, Pheretima, Flos Carthami, Semen Cuscutae, the Rhizoma Pinelliae to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating cerebral thrombosis.Wherein select Radix Bupleuri to be because its nature and flavor are bitter, cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain, and bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Radix Curcumae to be because its nature and flavor are arduous, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Selecting Radix Notoginseng is that temperature, enters liver, stomach, large intestine channel, has hemostasis because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select Radix Cyathulae to be because its nature and flavor are flat, bitter in the mouth, nontoxic, enter liver, kidney two warps, dispel the wind, dampness removing, stimulates the menstrual flow, the function of invigorating blood circulation, dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, there is dispelling the stagnated QI, loose painful abdominal mass, rushes down expectorant, and the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Select Flos Chrysanthemi be because its nature and flavor sweet, bitter, be slightly cold.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Select Spica Prunellae to be because its nature and flavor toil is cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, there is endogenous wind stopping, the function of arresting convulsion, controls dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, little Jing Epilepsy wind symptom.Select Bombyx Batryticatus to be because its nature and flavor are pungent, salty, flat.Return liver, lung meridian.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysis, infantile convulsion is twitched, and head is grant, sore throat, scrofula tuberculosis, rubella erysipelas.Select Fructus Lycii to be because its nature and flavor are sweet, flat, there is nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, and loses clear.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Carnis Naemorhedi to be because its nature and flavor are sweet, heat.Tonify deficiency is supporing yang.Control asthenia internal injury, a little less than muscles and bones numbness, spinal column is aching and limp, sexual impotence, and leukorrhagia, infertile.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Pheretima, have another name called Lumbricus, its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, controls height fanatical hot-tempered, convulsion with spasms, and headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.

The consumption of material medicine of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:

15-30 grams of 6-20 grams of Radix Salviae Miltiorrhizaes of 8-12 grams of Radix Curcumaes of Radix Bupleuri

10-30 grams of 10-20 grams of Rhizoma Alismatis of 6-12 grams of Radix Cyathulaes of Radix Notoginseng

5-15 grams of 10-25 grams of Fructus Aurantii Immaturuss of 15-35 grams of Poria of Fructus Ligustri Lucidi

9-25 grams, 10-23 grams of Rhizoma Gastrodiaes of 8-25 grams of Spica Prunellaes of Flos Chrysanthemi

6-20 grams of 12-30 grams of Radix Codonopsis of 6-20 grams of Fructus Lyciis of Bombyx Batryticatus

6-20 grams of 7-20 grams of Pheretimas of 13-27 grams of Rhizoma Atractylodis Macrocephalaes of Carnis Naemorhedi

8-22 grams of 10-25 grams of Rhizoma Pinelliaes of 5-15 grams of Semen Cuscutae of Flos Carthami

Preferable amount is

25 grams of 15 grams of Radix Salviae Miltiorrhizaes of 10 grams of Radix Curcumaes of Radix Bupleuri

20 grams of 18 grams of Rhizoma Alismatis of 8 grams of Radix Cyathulaes of Radix Notoginseng

10 grams of 20 grams of Fructus Aurantii Immaturuss of 25 grams of Poria of Fructus Ligustri Lucidi

15 grams, 15 grams of Rhizoma Gastrodiaes of 15 grams of Spica Prunellaes of Flos Chrysanthemi

15 grams of 20 grams of Radix Codonopsis of 15 grams of Fructus Lyciis of Bombyx Batryticatus

15 grams of 15 grams of Pheretimas of 15 grams of Rhizoma Atractylodis Macrocephalaes of Carnis Naemorhedi

15 grams of 15 grams of Rhizoma Pinelliaes of 12 grams of Semen Cuscutae of Flos Carthami

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry;

2, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;

3, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

4, Radix Notoginseng: choose clean impurity, run through rear section and dry;

5, Radix Cyathulae: choose decontamination, dry;

6, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

7, Fructus Ligustri Lucidi: choose decontamination, clean, dry;

8, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

9, Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section, dries;

10, Flos Chrysanthemi: get crude drug, except destemming, leaf and impurity, sieve dedust bits;

11, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

12, Rhizoma Gastrodiae: choose decontamination, big or small stepping, is soaked in water to seventy percent saturating, pulls out, slightly dries in the air, then moistens to internal and external temperature evenly, and section, dries;

13, Bombyx Batryticatus (parched): get clean Bombyx Batryticatus, fry to surface yellow;

14, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

15, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

16, Carnis Naemorhedi: clean, dry;

17, Rhizoma Atractylodis Macrocephalae (parched): first wheat bran is spread in heat pot, when time cigarette is emerged, pours Rhizoma Atractylodis Macrocephalae sheet into micro-stir-fry to faint yellow, take out, sieve goes to cool after wheat bran, and 100 jin of every Rhizoma Atractylodis Macrocephalae sheets, with 10 jin, wheat bran;

18, Pheretima: choose decontamination, water rinses, and pulls out in time, dries cutting;

19, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

20, Semen Cuscutae: cross sieve and remove impurity, clean, dry;

21, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): get the Rhizoma Pinelliae of choosing clean, soak 10 with cold water, when playing foam, 100 jin of every Rhizoma Pinelliaes add 2 jin of Alumens, steeps after 1 day and changes water again, to the slightly spicy sense of mouthfeel be degree.Separately get Rhizoma Zingiberis Recens section and decoct soup, add Alumen and the Rhizoma Pinelliae well-done altogether, take out, dry in the air to sixty percent dry, after moistening, cut into slices, dry, 100 jin of every Rhizoma Pinelliaes, with 25 jin, Rhizoma Zingiberis Recens, use 12 jin 8 liang of Alumens winter, and summer is with 14 jin 8 liang.

Two, preparation

1, by the Radix Bupleuri of described weight, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Cyathulae, Rhizoma Alismatis, Fructus Ligustri Lucidi, Poria, Fructus Aurantii Immaturus, Flos Chrysanthemi, Spica Prunellae, Rhizoma Gastrodiae, Bombyx Batryticatus, Fructus Lycii, Radix Codonopsis, Carnis Naemorhedi, Rhizoma Atractylodis Macrocephalae (parched), Pheretima, Flos Carthami, Semen Cuscutae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medicine decocts with water, and adds for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, then within 15 minutes, obtains decoction liquor for the first time with slow fire boiling, and decoction liquor is poured in container for the first time.

2, the medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time.

3, twice decoction liquor carried out to mixing and stirring, then use slow fire boiling 20 minutes, be divided into 4 doses and take.

Medicine of the present invention has invigorating the spleen and replenishing QI, dispelling wind and relieving convulsion, and the function of mind tranquilizing and the heart calming, is used for the treatment of cerebral thrombosis, short treating period, instant effect, cure rate is high.

The specific embodiment

By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, every day three times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] Drug therapy cerebral thrombosis of the present invention:

1, physical data

Accept out-patient's totally 165 examples for medical treatment, early stage patient 120 examples wherein, middle late patient's 45 examples.

2, diagnostic criteria

Early stage patients with mild performance central hemiplegia, facial paralysis and contralateral limbs are felt to go down.Most patient sanity, headache, vomiter is more rare.The middle and advanced stage state of an illness is compared with severe one, and often with the symptom of disturbance of consciousness and intracranial hypertension, common dizzy, nauseating, vomiting, intercrossing motion and sensory disturbance, dysphagia, drinking-water are sent out the symptom such as choke.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, patients with mild sooner or later each once, a potion.Within 10 days, be a course for the treatment of, take continuously 2 courses for the treatment of.Severe patient takes 6 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: after treatment, the symptom such as dizzy, nauseating, the headache of patient and aphasia is eliminated, and limbs are regained consciousness, and it is normal that body constitution is recovered, observation half a year is without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy cerebral thrombus patient's 165 examples of the present invention, patients with mild 120 examples wherein, effective 100 examples of result, obvious effective rate is 83.3%, 16 examples that take a turn for the better, improvement rate is 13.3%, total effective rate is 96.7%; Severe patient's 45 examples, effective 38 examples of result, obvious effective rate is 84.4%, 4 examples that take a turn for the better, improvement rate is 8.9%, invalid 3 examples, total effective rate is 93.3%.

Claims

1. a medicine for the treatment of cerebral thrombosis, is characterized in that: it is to be made by the crude drug in following weight range:

8-22 grams of 10-25 grams of Rhizoma Pinelliaes of 5-15 grams of Semen Cuscutae of Flos Carthami.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

15 grams of 15 grams of Rhizoma Pinelliaes of 12 grams of Semen Cuscutae of Flos Carthami.

3. the preparation method of medicine according to claim 1, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry;

(2) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;

(3) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(4) Radix Notoginseng: choose clean impurity, run through rear section and dry;

(5) Radix Cyathulae: choose decontamination, dry;

(6) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

(7) Fructus Ligustri Lucidi: choose decontamination, clean, dry;

(8) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(9) Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant saturating, pull out, profit is to interior without hard-core, and section, dries;

(10) Flos Chrysanthemi: get crude drug, except destemming, leaf and impurity, sieve dedust bits;

(11) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

(12) Rhizoma Gastrodiae: choose decontamination, big or small stepping, is soaked in water to seventy percent saturating, pulls out, slightly dries in the air, then moistens to internal and external temperature evenly, and section, dries;

(13) Bombyx Batryticatus (parched): get clean Bombyx Batryticatus, fry to surface yellow;

(14) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(15) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(16) Carnis Naemorhedi: clean, dry;

(17) Rhizoma Atractylodis Macrocephalae (parched): first wheat bran is spread in heat pot, when time cigarette is emerged, pours Rhizoma Atractylodis Macrocephalae sheet into micro-stir-fry to faint yellow, take out, sieve goes to cool after wheat bran, and 100 jin of every Rhizoma Atractylodis Macrocephalae sheets, with 10 jin, wheat bran;

(18) Pheretima: choose decontamination, water rinses, and pulls out in time, dries cutting;

(19) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(20) Semen Cuscutae: cross sieve and remove impurity, clean, dry;

(21) Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): get the Rhizoma Pinelliae of choosing clean, soak 10 with cold water, when playing foam, 100 jin of every Rhizoma Pinelliaes add 2 jin of Alumens, steeps after 1 day and changes water again, to the slightly spicy sense of mouthfeel be degree; Separately get Rhizoma Zingiberis Recens section and decoct soup, add Alumen and the Rhizoma Pinelliae well-done altogether, take out, dry in the air to sixty percent dry, after moistening, cut into slices, dry, 100 jin of every Rhizoma Pinelliaes, with 25 jin, Rhizoma Zingiberis Recens, use 12 jin 8 liang of Alumens winter, and summer is with 14 jin 8 liang;

(2) preparation

(1) by the Radix Bupleuri of described weight, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Cyathulae, Rhizoma Alismatis, Fructus Ligustri Lucidi, Poria, Fructus Aurantii Immaturus, Flos Chrysanthemi, Spica Prunellae, Rhizoma Gastrodiae, Bombyx Batryticatus, Fructus Lycii, Radix Codonopsis, Carnis Naemorhedi, Rhizoma Atractylodis Macrocephalae (parched), Pheretima, Flos Carthami, Semen Cuscutae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medicine decocts with water, and adds for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, then within 15 minutes, obtains decoction liquor for the first time with slow fire boiling, and decoction liquor is poured in container for the first time;

(2) medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time;

(3) twice decoction liquor carried out to mixing and stirring, then with slow fire boiling 20 minutes and get final product.