CN102657334A - Hard capsules taking grape seed extracts as raw materials and preparation method for hard capsules - Google Patents

Hard capsules taking grape seed extracts as raw materials and preparation method for hard capsules Download PDF

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CN102657334A
CN102657334A CN 201210146002 CN201210146002A CN102657334A CN 102657334 A CN102657334 A CN 102657334A CN 201210146002 CN201210146002 CN 201210146002 CN 201210146002 A CN201210146002 A CN 201210146002A CN 102657334 A CN102657334 A CN 102657334A
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grape seed
seed extract
capsule
raw materials
extract
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CN 201210146002
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CN102657334B (en )
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王可平
钟进义
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青岛海隆达生物科技有限公司
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Abstract

The invention relates to hard capsules taking grape seed extracts as raw materials and a preparation method for the hard capsules. The hard capsules comprise capsule hulls and contents, wherein the contents are prepared from the grape seed extracts used as the main raw materials and ginkgo powder, and comprise the following raw materials in percentage by weight: 94 percent of grape seed extract and 6 percent of ginkgo powder; and the content of procyanidins in the grape seed extracts is more than or equal to 90 percent. By the hard capsules, the proportion of the grape seed extracts in a formula is improved, the ginkgo powder is added, other fillings are not added, and the two raw materials are mixed uniformly to be filled into the capsules, so that the processing cost is reduced, and thetechnical problem that the capsules are low in curative effect and have certain side effect is solved. Scientific experiments prove that the grape seed extracts are compatible with the ginkgo powder,and the capacity of free radical removal and oxidation resistance is improved under the synergistic action of flavonoid substances contained in ginkgo and the procyanidins in the grape seed extracts,so the hard capsules have the effects of inhibiting lipid peroxidation and preventing and controlling oxidative damage well.

Description

以葡萄籽提取物为原料的硬胶囊及其制备方法 Grape seed extract as a raw material and a hard capsule preparation method

技术领域 FIELD

[0001] 本发明涉及胶囊类保健产品,具体地说,涉及一种含有葡萄籽提取物的胶囊及其制备方法。 [0001] The present invention relates to a capsule for health care products, and more particularly, relates to a capsule preparation method comprises grape seed extract.

背景技术 Background technique

[0002] 葡萄籽提取物是从葡萄籽中提取的一种人体内不能合成的新型高效天然氧化剂物质,它是一种高效能抗氧化、自由基清除剂,其抗氧化活性大于维生素E、维生素C等抗氧化营养素,对人体具有高抗氧化作用、降低红细胞的聚集作用和降低毛细血管的渗透作用。 [0002] Grape seed extract is a human extracted from grape seeds can not be synthesized in vivo oxidant new and efficient natural substances, it is a high antioxidant, radical scavenger, antioxidant activity is greater than that of vitamin E, vitamin C and other antioxidant nutrients, having a high antioxidant activity in the human body, reducing the aggregation of red blood cells and reduced infiltration of capillaries. 现有含有葡萄籽提取物的保健制剂如美国的“葡乐安”、加拿大的“得宝素”和中国专利申请号为00121388. I公开的一种复合胶囊,除含有葡萄籽提取物外,还含有碳酸钠、绞股蓝、灵芝孢子粉等辅助添加伍,其中葡萄籽提取物的含量仅在10-20%。 Existing health preparations containing grape seed extract, such as the United States, "the Portuguese Lok," Canada's "Depot factor" and Chinese Patent Application No. 00121388. I open a composite capsule, in addition to containing grape seed extract, further comprising sodium carbonate, Gynostemma, Ganoderma lucidum spore powder Wu auxiliary additive, wherein the content of grape seed extract is only 10-20%. 因这些产品中原花青素含量较低,消费者为达到一定的原花青素用量,不得不连带食用较多的胶囊壳及其它辅助添加物,这些辅助添加物对有些人会有胃酸增加等副作用,而且降低了产品的功效,增加了产品的成本和消费者经济负担,缩小了消费者群体。 These products are low because proanthocyandins content, consumers reach a certain amount of proanthocyanidins, have to eat more of the joint capsule shells and other auxiliary additives, these additives to assist some people have side effects such as increased gastric acid, but also reduces the efficacy of the product, increasing the cost of consumer and economic burden of products, reduced consumer groups.

发明内容 SUMMARY

[0003] 本发明针对现有含有葡萄籽提取物的胶囊产品疗效低、产品成本高、并有少量副作用的技术问题,提供了一种有效成分高、清除自由基和抗氧化性能高、且成本低、具有良好保健性能的以葡萄籽提取物为原料的硬胶囊及其制备方法。 [0003] The present invention is low, high production costs and technical problems have fewer side effects, there is provided an active ingredient for a high efficacy of the conventional capsule products contain grape seed extract, clear high radical and oxidation resistance, and cost low, with good health and performance of the hard capsule preparation method of grape seed extract as a raw material.

[0004] 本发明的技术方案是:一种以葡萄籽提取物为原料的硬胶囊,该硬胶囊包括胶囊外壳和内装物,所述的内装物为以葡萄籽提取物为主要原料,辅以白果粉制作而成,其原料按照重量百分比为:葡萄籽提取物94%、白果粉6% ;其中,葡萄籽提取物中原花青素的含量彡90%。 [0004] aspect of the present invention is: a kind of grape seed extract as a raw material of hard capsule, the hard capsule comprising a capsule shell and contents, to the contents of grape seed extract as the main raw material, supplemented ginkgo powder made of, as raw materials according to the weight percentages: 94% grape seed extract, ginkgo powder 6%; wherein the content of San grape seed extract 90% of procyanidins.

[0005] 本发明的另一目的在于提供了一种以葡萄籽提取物为原料制备硬胶囊的方法,该硬胶囊的内容物原料按照重量百分比为:葡萄籽提取物94%、白果粉6%,其制备步骤为: [0005] Another object of the present invention to provide a method of grape seed extract prepared starting from the hard capsule, the hard material in accordance with the contents of the capsule weight percentage: 94% grape seed extract, ginkgo powder 6% , preparation steps of:

[0006] (I)葡萄籽提取物的制备:a、取葡萄酒厂榨汁后含有葡萄籽和葡萄皮的葡萄渣,将葡萄渣清洗去皮后,取葡萄籽晾干;b、将葡萄籽置于提取罐中,加入葡萄籽2倍体积的70%酒精溶液浸泡提取;C、收集提取液并蒸发回收乙醇,将剩余提取液加入纯化剂纯化处理;d、将提纯后的提取液进行喷雾干燥,干燥后的粉状物为葡萄籽提取物;e、对葡萄籽提取物进行原花青素含量检测,保证葡萄籽提取物中原花青素的含量> 90% ;f、将葡萄籽提取物无菌、真空包装后避光保藏备用; [0006] Preparation of (I) Grape seed extract: a, after taking winery grape seed and grape juice containing skin grape pomace, grape pomace after washed, peeled, taken dry grape seed; B, grape seed was placed in an extraction tank, grape seed was added 2 volumes of 70% alcohol solution immersion extraction; C, the extract was collected and evaporated recovering ethanol, the extract was added purifying agent remaining purification; D, the purified extract was spray after drying the powder was dried grape seed extract; E, grape seed extract proanthocyanidin content detection, grape seed extract to ensure procyanidins content> 90%; f, sterile grape seed extract in vacuo packaged dark standby deposited;

[0007] (2)白果粉的制备:将市场上销售清洁卫生的白果经60°C,4-5小时干燥、粉碎、过200目筛制成粉状备用; [0008] (3)混合:将制备好的葡萄籽提取物和白果粉按上述比例置于已用酒精消毒处理的V型混合机中充分混匀; [0007] (2) Preparation of ginkgo powder: the clean ginkgo marketed by 60 ° C, 4-5 hours and dried, pulverized and sieved through a 200 mesh screen made of powdered standby; [0008] (3) mixing: the grape seed extract prepared and placed in the above proportions ginkgo powder V-blender sterilized treated with alcohol and mix well;

[0009] (4)包装:将混合后的产品原料按IOOg/袋真空包装;[0010] (5)胶囊填充机装:取一袋IOOg/袋的产品原料置于已用酒精消毒处理的胶囊填充机料盒内,将空胶囊置于胶囊填充机上,开动机器自动将产品原料填充于胶囊内制成胶囊制剂,即为硬胶囊产品。 [0009] (4) Packing: After mixing the raw materials by IOOg / bag vacuum packing; [0010] (5) a capsule filling machine means: taking a bag IOOg / capsule placed in the bag raw materials treated with alcohol filling machine within the cartridge, the empty capsules are placed on a capsule filling machine, the machine will automatically start raw materials filled in capsules made from the capsule formulation, i.e. hard capsule products.

[0011] 本发明的有益效果是:本发明胶囊中提高了葡萄籽提取物在配方中的比例,加入白果粉,不含有其他填料。 [0011] Advantageous effects of the invention are: a capsule in the present invention increases the proportion of grape seed extract in the formulation, was added ginkgo powder, containing no other fillers. 克服了人们普遍遇到的原花青素不能大剂量服用的问题,解决了含有葡萄籽提取物胶囊疗效低、产品成本过高,并具有一定副作用的技术问题。 To overcome the problems commonly encountered by people proanthocyanidins large doses can not solve the low efficacy capsules containing grape seed extract, product costs are too high and have some side effects of technical problems. 经科学实验证明,葡萄籽提取物与白果粉配伍,因白果既是食品又是药品,含有丰富类黄酮物质,可与葡萄籽提取物中的原花青素起协同作用,提高了清除自由基和抗氧化能力,具有抑制脂质过氧化,对氧化损伤有良好防治的作用,可促进细胞增殖活性,且具有抑制细胞凋亡、延缓衰老过程等保健功能。 By scientific evidence shows that grape seed extract and ginkgo powder compatibility, because ginkgo both food and medicine, rich in flavonoids, may act synergistically with grape seed extract proanthocyanidins, improve the free radical scavenging and antioxidant capacity , inhibit lipid peroxidation, has a good effect on the prevention and treatment of oxidative damage, promote cell proliferation and inhibit apoptosis, slow the aging process and other health functions. 本发明胶囊的制备方法简单,无其他附加成分,只需将制备好的两种原料混合均匀进行胶囊填充即可,可降低加工成本。 Capsule preparation method of the present invention is simple, no other additional ingredients, just prepared for a uniform mixing of the two raw materials to the capsule filling may reduce processing costs.

具体实施方式[0012] 以下对本发明作进一步说明。 DETAILED DESCRIPTION [0012] The following further illustrate the present invention.

[0013] 一种以葡萄籽提取物为原料的硬胶囊,该硬胶囊包括胶囊外壳和内装物,所述的内装物为以葡萄籽提取物为主要原料,辅以白果粉制作而成,其原料按照重量百分比为:葡萄籽提取物94%、白果粉6%;其中,葡萄籽提取物中原花青素的含量>90%。 [0013] In one kind of grape seed extract as a raw material of hard capsule, the hard capsule comprising a capsule shell and contents, to the contents of grape seed extract as the main raw material, supplemented ginkgo powder made which percentage by weight of raw materials: 94% grape seed extract, ginkgo powder 6%; wherein the grape seed extract of procyanidins content of> 90%.

[0014] 其制备步骤为: [0014] The preparation steps of:

[0015] (I)葡萄籽提取物的制备:a、取葡萄酒厂榨汁后含有葡萄籽和葡萄皮的葡萄渣,将葡萄渣清洗去皮后,取葡萄籽晾干;b、将葡萄籽置于提取罐中,加入葡萄籽2倍体积的70%酒精溶液浸泡提取;c、收集提取液并蒸发回收乙醇,将剩余提取液加入纯化剂纯化处理;d、将提纯后的提取液进行喷雾干燥,干燥后的粉状物为葡萄籽提取物;e、对葡萄籽提取物进行原花青素含量检测,保证葡萄籽提取物中原花青素的含量> 90% ;f、将葡萄籽提取物无菌、真空包装后避光保藏备用; [0015] Preparation of (I) Grape seed extract: a, after taking winery grape seed and grape juice containing skin grape pomace, grape pomace after washed, peeled, taken dry grape seed; B, grape seed was placed in an extraction tank, grape seed was added 2 volumes of 70% alcohol solution immersion extraction; C, the extract was collected and evaporated recovering ethanol, the extract was added purifying agent remaining purification; D, the purified extract was spray after drying the powder was dried grape seed extract; E, grape seed extract proanthocyanidin content detection, grape seed extract to ensure procyanidins content> 90%; f, sterile grape seed extract in vacuo packaged dark standby deposited;

[0016] (2)白果粉的制备:将市场上销售清洁卫生的白果经60°C,4-5小时干燥、粉碎、过200目筛制成粉状备用; [0016] (2) Preparation of ginkgo powder: sales on the market ginkgo clean by 60 ° C, 4-5 hours and dried, pulverized and sieved through a 200 mesh screen made of powdered standby;

[0017] (3)混合:将制备好的葡萄籽提取物和白果粉按上述比例置于已用酒精消毒处理的V型混合机中充分混匀; [0017] (3) Blending: grape seed extract prepared and placed in the above proportions ginkgo powder V-blender sterilized treated with alcohol and mix well;

[0018] (4)包装:将混合后的产品原料按IOOg/袋真空包装; [0018] (4) Packing: After mixing the raw materials by IOOg / bag vacuum packing;

[0019] (5)胶囊填充机装:取一袋IOOg/袋的产品原料置于已用酒精消毒处理的胶囊填充机料盒内,将空胶囊置于胶囊填充机上,开动机器自动将产品原料填充于胶囊内制成胶囊制剂,即为硬胶囊产品。 [0019] (5) a capsule filling machine means: taking a bag IOOg / bag raw materials within the cartridge placed in a capsule filling machine has been treated with alcohol, the empty capsules are placed on a capsule filling machine, the machine will automatically start raw materials filled into capsules for capsule preparations, namely hard capsule products.

[0020] 以上具体实施方式仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的精神和范围,其均应涵盖在本发明的权利要求范围当中。 [0020] The above specific embodiments are intended to illustrate and not limit the present invention, although the present invention has been described in detail with reference to preferred embodiments, those of ordinary skill will appreciate that modifications may be made to the technical solutions of the present invention. or equivalent replacements without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the present invention as claimed in which the required range.

Claims (2)

  1. 1. ー种以葡萄籽提取物为原料的硬胶囊,该硬胶囊包括胶囊外壳和内装物,其特征在干:所述的内装物为以葡萄籽提取物为主要原料,辅以白果粉制作而成,其原料按照重量百分比为:葡萄籽提取物94%、白果粉6% ;其中,葡萄籽提取物中原花青素的含量>90%。 1. ー more kinds of grape seed extract as a raw material of hard capsule, the hard capsule comprising a capsule shell and contents, characterized in that the dry: the contents of grape seed extract as the main raw material, supplemented produced ginkgo powder from which material is percentage by weight: 94% grape seed extract, ginkgo powder 6%; wherein the grape seed extract of procyanidins content of> 90%.
  2. 2. ー种以葡萄籽提取物为原料制备硬胶囊的方法,其特征在于:该硬胶囊的内容物原料按照重量百分比为:葡萄籽提取物94%、白果粉6%,其制备步骤为: (1)葡萄籽提取物的制备:a、取葡萄酒厂榨汁后含有葡萄籽和葡萄皮的葡萄渣,将葡萄渣清洗去皮后,取葡萄籽晾干山、将葡萄籽置于提取罐中,加入葡萄籽2倍体积的70%酒精溶液浸泡提取;c、收集提取液并蒸发回收こ醇,将剩余提取液加入纯化剂纯化处理;d、将提纯后的提取液进行喷雾干燥,干燥后的粉状物为葡萄籽提取物;e、对葡萄籽提取物进行原花青素含量检测,保证葡萄籽提取物中原花青素的含量> 90%ば、将葡萄籽提取物无菌、真空包装后避光保藏备用; (2)白果粉的制备:将市场上销售清洁卫生的白果经60°C,4-5小时干燥、粉碎、过200目筛制成粉状备用; (3)混合:将制备好的葡萄籽提取物 2. The method ー grape seed extract prepared starting from hard gelatin capsules wherein: the hard material in accordance with the contents of the capsule weight percentage: 94% grape seed extract, ginkgo powder 6%, which is prepared in the following steps: preparation of (1) grape seed extract: a, after taking winery grape seed and grape juice containing skin grape pomace, grape pomace after washed, peeled, taken grape seed dry Hill, grape seed placed in the extraction tank in 2 volumes of added grape seed 70% alcohol solution immersion extraction; C, extract was collected and evaporated recovered ko alcohol, the remaining extract is added purifying agent purification treatment; D, will extract the purified spray-dried, dried after the powder is grape seed extract; E, grape seed extract proanthocyanidin content detection, grape seed extract to ensure that the content of procyanidins> ba 90%, grape seed extract sterile, vacuum-packed after dark accession standby; (2) preparation of ginkgo powder: the clean ginkgo marketed by 60 ° C, 4-5 hours and dried, pulverized and sieved through a 200 mesh screen made of powdered standby; (3) mixing: good prepared grape seed extract 白果粉按上述比例置于已用酒精消毒处理的V型混合机中充分混匀; (4)包装:将混合后的产品原料按IOOg/袋真空包装; (5)胶囊填充机装:取一袋IOOg/袋的产品原料置于已用酒精消毒处理的胶囊填充机料盒内,将空胶囊置于胶囊填充机上,开动机器自动将产品原料填充于胶囊内制成胶囊制齐U,即为硬胶囊产品。 Ginkgo powder placed in the above proportions V-blender treated with alcohol fully mixed; (4) Packing: After mixing the raw materials by IOOg / bag vacuum packing; (5) a capsule filling machine fitted: Take a Bag IOOg / bag raw materials within the cartridge placed in a capsule filling machine has been treated with alcohol, the empty capsules are placed on a capsule filling machine, the machine will automatically start raw materials filled in capsules for capsule homogeneous system U, that is, hard capsule products.
CN 201210146002 2012-05-14 2012-05-14 Hard capsules taking grape seed extracts as raw materials and preparation method for hard capsules CN102657334B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401365A (en) * 2002-09-19 2003-03-12 太极集团有限公司 Chinese health medicine
CN1424032A (en) * 2002-12-30 2003-06-18 杜越新 Capsule agent with grape-seed extracts as raw material
CN1618333A (en) * 2004-12-09 2005-05-25 桂林莱茵生物制品有限公司 Anti-oxidation health-care food, and its prodn. method
CN101224260A (en) * 2006-12-13 2008-07-23 天津市弗兰德医药科技发展有限公司 Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401365A (en) * 2002-09-19 2003-03-12 太极集团有限公司 Chinese health medicine
CN1424032A (en) * 2002-12-30 2003-06-18 杜越新 Capsule agent with grape-seed extracts as raw material
CN1618333A (en) * 2004-12-09 2005-05-25 桂林莱茵生物制品有限公司 Anti-oxidation health-care food, and its prodn. method
CN101224260A (en) * 2006-12-13 2008-07-23 天津市弗兰德医药科技发展有限公司 Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张连富等: "原花青素提取及微胶囊化研究", 《天然产物研究与开发》, no. 04, 15 August 2007 (2007-08-15) *

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