CN102643163A - Method for preparing tertiary alcohol by means of Grignard reaction - Google Patents
Method for preparing tertiary alcohol by means of Grignard reaction Download PDFInfo
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Abstract
The invention provides a method for preparing tertiary alcohol by means of Grignard reaction, which includes: adding ethers and quaternary ammonium salt compounds into Grignard reagent to serve as addition agent to react with ketone so that the tertiary alcohol is prepared. The method has the advantages of simplicity in operation, mild reaction condition, low cost, high yield, environmental friendliness and suitability for industrial production.
Description
Technical field
The present invention relates to the method that a kind of grignard reaction prepares the tertiary alcohol.The tertiary alcohols compound is the important intermediate of agricultural chemicals, medicine and liquid crystal material.
Background technology
Grignard reagent to the nucleophilic addition of ketone be that preparation tertiary alcohols compound is the most important, utilization one of method the most widely.This method not only raw material be easy to get, simple to operate, therefore carbochain that can also the reaction of propagation thing can be used for preparing the various tertiary alcohols.Traditional Grignard reagent to the shortcoming of the nucleophilic addition existence of ketone is: in the nucleophilic addition process, follow the aldol condensation by product and reduction production of by-products of substrate itself usually, cause the yield of principal product to reduce greatly.
In order to stop the generation of these side reactions, report in succession in the document and use excessive additive, especially inorganic metal salt, be described below:
1.Imamoto having reported, group use normal anhydrous chlorides of rase caesium to promote reaction system (non-patent literature 1:Imamoto, the T. of Grignard reagent to the efficient addition of ketone as additive; Sugiura, Y.; Takiyama, N.Tetrahedron Lett.1984,25,4233-4236, non-patent literature 2:Imamoto, T.; Takiyama, N.; Nakamura, K.; Hatajima, T.; Kamiya, Y.J.Am.Chem.Soc.1989,111,4392-4398).
2.Knochel group has reported use LnCl
32LiCl has well promoted addition (non-patent literature 3:Krasovskiy, the A. of Grignard reagent to ketone; Kopp, F.; Knochel, P.Angew.Chem.Int.Ed.2006,45,497-500), confirmed to add the LnCl of 30mol% subsequently again
32LiCl just reacts very effectively (non-patent literature 4:Metzger, A. to this as additive; Gavryushin, A.; Knochel, P.Synlett 2009,9,1433-1436).
3.Ishihara group has reported [R
3Mg]
-[Li]
+The system of [LiX] mixture can well reduce generation (non-patent literature 5:Hatano, the M. of by product; Matsumura, T.; Ishihara, K.Org.Lett.2005,7,573-576), this group has reported the anhydrous ZnCl that in Grignard reagent, adds catalytic amount again subsequently
2Form [R
3Zn]
-[MgCl]
+[MgCl]
2The form of mixture promotes the carrying out of addition reaction, and unfortunately this reaction only is applicable to RMgCl (the R=aliphatic residue can not be an aromatic residue) (non-patent literature 6:Hatano, M.; Suzuki, S.; Ishihara, K.J.Am.Chem.Soc.2006,128,9998-9999).In order to improve the practicality of this reaction, this group finds to use ZnCl again
2(10mol%)-Me
3SiCH
2The system of MgCl (20mol%)-LiCl (110mol%) mixture goes for (non-patent literature 7:Hatano, M. in the addition reaction of multiple Grignard reagent to multiple ketone; Ito, O.; Suzuki, S.; Ishihara, K.J.Org.Chem.2010,75,5008-5016).
Yet above-mentioned several kinds of reaction systems all must be used the anhydrous metal salt, and (Ln for example, Li Zn) as additive, comes the activation carbonyl or forms active higher transition state midbody, reaches and reduces the purpose that side reaction improves productive rate.The shortcoming of its existence is: 1, additive costs an arm and a leg, and is prone to the moisture absorption, weighing in glove box, be not suitable for suitability for industrialized production.2, with metal-salt as additive, be prone to residual little metal ion after the aftertreatment in the product, final metals ion remains in and can cause environment unfriendlyly in the agricultural chemicals, remains in and not only can reduce drug effect in the pharmaceutical prod and human health is had very big influence.
Summary of the invention
The objective of the invention is to, provide a kind of eco-friendly, low-cost, grignard reaction prepares the method for tertiary alcohols compound efficiently.
The invention is characterized in: through using cheap ethers and quaternary ammonium compound to reduce reaction cost and improving Grignard reagent carries out nucleophilic addition(Adn) to substrate ketone reaction yield.
The technical scheme that the present invention adopted is following: grignard reaction prepares the method for the tertiary alcohol, comprises the nucleophilic addition step to ketone compounds, adds ethers and quaternary ammonium compound in this step.
The general formula of described ether compound is R
1-O-(CH
2CH
2O)
n-R
2, R in the formula
1, R
2The expression alkyl, n>=0.Ether compound preferred 1; 4-dioxane (1; 4-dioxane), Methylal(dimethoxymethane) (DMM), glycol dimethyl ether (DME), ethylene glycol bisthioglycolate ethyl ether (DEE), diethylene glycol dimethyl ether (DGDE), diethylene glycol diethyl ether, Diethylene Glycol dibutyl ether, NHD (DiMPEG), 12-crown-4,15-hat-5,18-hat-6, more preferably from glycol dimethyl ether, diethylene glycol dimethyl ether.
The general formula of described quaternary ammonium compound is R
3R
4R
5R
6N
+X
-, R wherein
3Expression C1～C18 alkyl or ethene are high molecular polymer, R
4, R
5, R
6The expression alkyl, X representes halogen group.The preferred Methanaminium, N,N,N-trimethyl-, fluoride of quaternary ammonium salt (TMAF); Tetramethyl ammonium chloride (TMAC); Etamon chloride (TEAC); Tetraethylammonium bromide (TEAB); Tetrabutylammonium chloride (TBAC); Tetrabutyl amonium bromide (TBAB); Tetrabutylammonium iodide (TBAI); Tetrabutylammonium perchlorate (TBAP); DTAC (DTAC); Tetradecyl trimethyl ammonium chloride (TTAC); OTAC (STAC); Ethene is high molecular polymer trimethyl ammonium chloride (being that ethene is chlorine type resin anion(R.A)).More preferably tetrabutylammonium chloride (TBAC), Tetrabutyl amonium bromide (TBAB).
Reaction formula of the present invention is following:
R ', R ", R=alkyl, aryl;
X is a halogen atom.
Its concrete steps are: in Grignard reagent, add ethers and quaternary ammonium compound as additive; Its mol ratio is: Grignard reagent: ether: quaternary ammonium salt=1.1～3.0: 1.1～3.0: 0.1～1.0, stir, at low temperatures the tetrahydrofuran solution of slow dropwise reaction thing ketone; Dropwise; Rise to room temperature gradually, after reacting completely, drip NH
4Ethyl acetate extraction is used in Cl aqueous solution quencher reaction, the saturated sodium-chloride washing, and anhydrous sodium sulfate drying filters, and concentrates, and rapid column chromatography obtains the title product tertiary alcohol.
Grignard reagent of the present invention, be meant by Organohalogen compounds and MAGNESIUM METAL 99 prepared in reaction and organometallic reagent.The Organohalogen compounds that are used for preparing Grignard reagent are methyl iodide, monobromethane, monochloroethane, N-PROPYLE BROMIDE, chloropropane, bromo propane, chloroisopropane, NBB, chlorobutane, isobutane bromide, chloro-iso-butane, allyl bromide 98, bromobenzene, chlorobenzene, p-Fluoro bromo benzene, N, N-dimethyl chloride propane.
Substrate ketone compounds of the present invention has methyl phenyl ketone, parachloroacetophenone, p-methoxy-acetophenone, to fluoro acetophenone, to trifluoromethyl acetophenone, 1-acetonaphthone, 2-acetonaphthone, trifluoromethyl acetophenone, Tetralone an intermediate of Sertraline, pimelinketone, benzophenone, benzene pentanone, Propiophenone, hexanone, 1-pentanone, 2 pentanone etc.
Advantage of the present invention is to have developed use ethers and quaternary ammonium salt first as additive, promotes the nucleophilic addition of Grignard reagent to ketone, significantly reduces the by product that generates in the reaction process.Operation is simple, is applicable to suitability for industrialized production, and additive is cheap, and non-metallic ion is participated in, and environmental friendliness more can satisfy the principles and policies of government's energy-saving and emission-reduction.
Embodiment
Below utilize case study on implementation and comparative example that the present invention at length is described.But the invention is not restricted to the form shown in the case study on implementation, concrete embodiment can carry out various changes in the scope of embodiment explanation of the present invention.
The preparation of embodiment 1:n-BuMgBr Grignard reagent
In the 250mL there-necked flask, add 2.55g (105mmol) magnesium chips, add 3 iodine grains (as initiator); And the feeding nitrogen protection, add 10mL exsiccant THF submergence magnesium chips, start stirring; Add 1.0mL n-BuBr, add thermal booster reaction, cause the color fade that is masked as the iodine grain; THF refluxes, and the magnesium chips surface is shinny, and magnesium chips tails off gradually.After causing completion, stop heating, slowly drip the THF solution (containing n-BuBr 9.8mL, exsiccant THF solution 90mL) of n-BuBr, drip and finish post-heating to 65 ℃ backflow 1h.The titration of Grignard reagent is with reference to acid, and the n-BuMgBr concentration that synthesizes by this operation steps and reagent throwing amount is about 1mol/L.
Synthesizing of embodiment 2:2-phenyl-2-hexanol
In the 50mL round-bottomed flask, add quaternary ammonium salt tetrabutylammonium chloride (TBAC) (27.8mg, 0.1mmol), charge into nitrogen-sealed after; Slowly drip Grignard reagent n-BuMgBr (1.5mL, 1.5mmol, 1.0M in THF), stir 10min under the room temperature; Add then diethylene glycol dimethyl ether (DGDE) (0.21mL, 201mg, 1.5mmol), continue to stir 30min under the room temperature after; Be cooled to 0～5 ℃ gradually by room temperature, slowly add the tetrahydrofuran solution (120mg, 1.0mmol, 1.0M in THF) of methyl phenyl ketone.
Dropwise, reaction solution rose to stirring at room 2 hours gradually, after reaction is accomplished with the saturated NH of 5mL
4Cl aqueous solution quencher reaction with ethyl acetate extraction (10mL * 3), with saturated sodium-chloride washing (5mL), use anhydrous sodium sulfate drying 20min, and filtration is gone out the solvent of filtrating with Rotary Evaporators and obtained crude product.Use the solvent of petrol ether/ethyl acetate=15/1 to be developping agent, obtain pure product 2-phenyl-2-hexanol, productive rate 92% through silica gel column chromatography.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400spectrometer):
1H NMR (400MHz, CDCl
3) δ 0.89 (m, 3H), 1.15-1.34 (m, 4H), 1.59 (s, 3H), 1.81-1.88 (m, 2H), 2.04 (s, 1H), 7.25-7.49 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 14.1,23.1,26.2,30.1,44.0,74.7,124.8,126.5,128.3,148.2.
Synthesizing of comparative example 1:2-phenyl-2-hexanol
Use the device same, do not use the diethylene glycol dimethyl ether additive, under the condition shown in the table 1, react with embodiment 2.The result shows and table 1.
Synthesizing of comparative example 2:2-phenyl-2-hexanol
Use the device same, do not use the quaternary ammonium salt tetrabutylammonium chloride, under the condition shown in the table 1, react with embodiment 2.The result shows and table 1.
Synthesizing of comparative example 3:2-phenyl-2-hexanol
Use the device same, do not use diethylene glycol dimethyl ether additive and quaternary ammonium salt tetrabutylammonium chloride, under the condition shown in the table 1, react with embodiment 2.The result shows and table 1.
Table 1
Synthesizing of embodiment 3:3-methyl-2-phenyl-2-butanols
Replace n-BuMgBr with i-PrMgBr, building-up process is with embodiment 2.Productive rate: 82%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.82 (d, J=6.9Hz, 3H), 0.90 (d, J=6.9Hz, 3H), 1.53 (s, 3H), 1.73 (s, 1H), 2.03 (septet, J=6.9Hz, 1H), 7.20-7.45 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 17.2,17.4,26.7,38.6,76.7,125.3,126.4,127.9,147.8.
Synthesizing of embodiment 4:2-phenyl-2-butanols
Replace n-BuMgBr with EtMgBr, building-up process is with embodiment 2.Productive rate: 95%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.83 (t, J=7.4Hz, 3H), 1.58 (s, 3H), 1.77 (s, 1H), 1.87 (m, 2H), 7.24-7.47 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 8.3,29.6,36.7,74.9,124.9,126.5,128.1,147.8.
Synthesizing of embodiment 5:2-phenyl-4-amylene-2-alcohol
Replace n-BuMgBr with AllylMgBr, building-up process is with embodiment 2.Productive rate: 99%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3) δ 1.57 (s, 3H), 2.25 (s, 1H), 2.52 (dd, J=8.2Hz, 13.8Hz, 1H), 2.70 (dd, J=8.2Hz, 13.8Hz, 1H), 5.15 (m, 2H), 5.66 (m, 1H), 7.24-7.48 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 29.9,48.5,73.7,119.4,124.8,126.6,128.2,133.8,147.7.
Embodiment 6:1,1-phenylbenzene alcoholic acid is synthetic
Replace n-BuMgBr with PhMgBr, building-up process is with embodiment 2.Productive rate: 94%.Product is a white solid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 1.96 (s, 3H), 2.25 (s, 1H), 7.25 (m, 2H), 7.32 (t, J=7.19Hz, 4H), 7.42 (m, 4H);
13C NMR (100MHz, CDCl
3) δ 30.9,76.2,125.8,127.0,128.2,148.0.
Synthesizing of embodiment 7:1-(4-F-phenyl)-1-phenylethyl alcohol
With 4-F-C
6H
4MgBr replaces n-BuMgBr, and building-up process is with embodiment 2.Productive rate: 90%.Product is a white solid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 1.95 (s, 3H), 2.67 (s, 1H), 7.02 (t, J=8.7Hz, 2H), 7.30-7.45 (m, 7H);
13C NMR (100MHz, CDCl
3) δ 30.8,75.8,114.7 (d, J=21.1Hz), 125.7,127.0,127.5 (d, J=8.0Hz), 128.1,143.7 (d, J=3.2Hz), 147.7,160.4,162.8.
19F NMR (376MHz, CDCl
3) δ-115.96.
Synthesizing of embodiment 8:2-methyl-3-phenyl-3-amylalcohol
In the 50mL round-bottomed flask, and adding quaternary ammonium salt tetrabutylammonium chloride (TBAC) (27.8mg, 0.1mmol); After charging into nitrogen-sealed, slowly drip Grignard reagent i-PrMgBr (1.5mL, 1.5mmol; 1.0M in THF), stir 10min under the room temperature, add diethylene glycol dimethyl ether (DGDE) (0.21mL then; 201mg after 1.5mmol) at room temperature 30min is stirred in continuation, is cooled to 0～5 ℃ by room temperature gradually; Under this temperature, Propiophenone (134mg, 1.0mmol, 1.0M in THF) is slowly joined in the reaction mixture.
Dropwise, mixed solution rose to stirring at room 2 hours gradually, after reaction is accomplished with the saturated NH of 5mL
4Cl aqueous solution quencher reaction with ethyl acetate extraction (10mL * 3), with saturated sodium-chloride washing (5mL), use anhydrous sodium sulfate drying 20min, and filtration is gone out the solvent of filtrating with Rotary Evaporators and obtained crude product.Use the solvent of petrol ether/ethyl acetate=15/1 to be developping agent, obtain pure product 2-methyl-3-phenyl-3-amylalcohol, productive rate 92% through silica gel column chromatography.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.70 (t, J=7.3Hz, 3H), 0.72 (d, J=6.9Hz, 3H), 0.95 (d, J=6.9Hz, 3H), 1.59 (s, 1H), 1.89 (q, J=6.9Hz, 2H), 2.05 (septet, J=6.9Hz, 1H), 7.18-7.40 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 7.9,16.6,17.5,32.0,37.5,79.3,125.9,126.1,127.7,145.0.
Synthesizing of embodiment 9:2-methyl-3-phenyl-3-amylalcohol
Replace Propiophenone with the benzene pentanone, building-up process is with embodiment 7.Productive rate: 85%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.72 (d, J=6.8Hz, 3H), 0.83 (t, J=7.3Hz, 3H), 0.95 (m, 4H), 1.25 (m, 3H), 1.61 (d, J=11.8Hz, 1H), 1.85 (m, 2H), 2.04 (septet, J=6.9Hz, 1H), 7.20-7.38 (m, 5H);
13C NMR (100MHz, CDCl
3) δ 14.0,16.6,17.4,23.2,25.8,37.8,39.4,79.0,125.8,126.1,127.7,145.5.
Synthesizing of embodiment 10:3-methyl-2-(4-p-methoxy-phenyl) butyl-2-alcohol
Replace Propiophenone with p-methoxy-acetophenone, building-up process is with embodiment 7.Productive rate: 82%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.82 (d, J=6.9Hz, 3H), 0.86 (d, J=6.9Hz, 3H), 1.50 (s, 3H), 1.69 (br, 1H), 1.98 (septet, J=6.9Hz, 1H), 3.80 (s, 3H), 6.84-6.89 (m, 2H), 7.30-7.36 (m, 2H);
13C NMR (100MHz, CDCl
3) δ 17.2,17.4,26.4,38.7,55.2,76.5,113.1,126.4,139.9,158.0.
Synthesizing of embodiment 11:3-methyl-2-(4-(trifluoromethyl) phenyl) butyl-2-alcohol
So that trifluoromethyl acetophenone is replaced Propiophenone, building-up process is with embodiment 7.Productive rate: 89%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.77 (d, J=6.9Hz, 3H), 0.91 (d, J=6.9Hz, 3H), 1.53 (s, 3H), 1.75 (br, 1H), 2.02 (septet, J=6.9Hz, 1H), 7.53 (d, J=8.4Hz, 2H), 7.58 (d, J=8.4Hz, 2H);
13C NMR (100MHz, CDCl
3) δ 16.9,17.3,27.1,38.5,77.3,123.0,124.8 (q, J=271.0Hz), 125.7,128.8 (q, J=32.4Hz), 151.8.
19F NMR (376MHz, CDCl
3) δ-62.38.
Synthesizing of embodiment 12:3-methyl-2-(2-naphthyl)-2-butanols
Replace Propiophenone with the 2-acetonaphthone, building-up process is with embodiment 7.Productive rate: 80%.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.92 (d, J=6.9Hz, 3H), 1.02 (d, J=6.9Hz, 3H), 1.68 (s, 3H), 2.09 (s, 1H), 2.21 (septet, J=6.9Hz, 1H), 7.51-7.62 (m, 3H), 7.86-7.92 (m, 3H), 7.98 (m, 1H);
13C NMR (100MHz, CDCl
3) δ 17.3,17.6,26.8,38.5,77.0,123.8,124.2,125.7,126.0,127.5,127.6,128.3,132.3,133.2,145.5.
Embodiment 13:1-sec.-propyl-1,2,3,4-1-tetralol synthetic
In the 50mL round-bottomed flask of magnetic agitation, constant pressure funnel, nitrogen protection device is housed, and adding quaternary ammonium salt tetrabutylammonium chloride (TBAC) (27.8mg, 0.1mmol); After charging into nitrogen-sealed, slowly drip Grignard reagent i-PrMgBr (3.0mL, 3.0mmol; 1.0M in THF), stir 10min under the room temperature, add diethylene glycol dimethyl ether (DGDE) (0.42mL then; 402mg after 3.0mmol) at room temperature 30min is stirred in continuation, is cooled to 0～5 ℃ by room temperature gradually; Under this temperature, Propiophenone (134mg, 1.0mmol, 1.0M in THF) is slowly joined in the reaction mixture.
Dropwise, mixed solution rose to stirring at room 2 hours gradually, after reaction is accomplished with the saturated NH of 5mL
4Cl aqueous solution quencher reaction with ethyl acetate extraction (10mL * 3), with saturated sodium-chloride washing (5mL), use anhydrous sodium sulfate drying 20min, and filtration is gone out the solvent of filtrating with Rotary Evaporators and obtained crude product.Use the solvent of petrol ether/ethyl acetate=15/1 to be developping agent, obtain pure product 2-methyl-3-phenyl-3-amylalcohol, productive rate 80% through silica gel column chromatography.Product is a colourless oil liquid.Nmr analysis (Burker AVANCE 400 spectrometer):
1H NMR (400MHz, CDCl
3, TMS) δ 0.66 (d, J=6.9Hz, 3H), 1.09 (d, J=6.9Hz, 3H), 1.62-1.89 (m; 5H), 2.40 (septet, J=6.9Hz, 1H), 2.60-2.84 (m, 2H), 7.08 (d; J=7.5Hz, 1H), 7.14-7.26 (m, 2H), 7.52 (d, J=7.5Hz, 1H);
13C NMR (100MHz, CDCl
3) δ 16.3,18.4,19.1,30.3,30.9,37.4,74.4,126.1,126.4,126.8,128.9,137.8,141.6.
Claims (8)
1. a grignard reaction prepares the method for the tertiary alcohol, comprises the nucleophilic addition step to ketone compounds, it is characterized in that: add ethers and quaternary ammonium compound in this step.
2. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: the general formula of described ether compound is R
1-O-(CH
2CH
2O)
n-R
2, R in the formula
1, R
2The expression alkyl, n>=0.
3. grignard reaction according to claim 1 prepares the method for the tertiary alcohol; It is characterized in that: described ether compound is selected from 1,4-dioxane, Methylal(dimethoxymethane), glycol dimethyl ether, ethylene glycol bisthioglycolate ethyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, Diethylene Glycol dibutyl ether, NHD, 12-crown-4,15-hat-5 or 18-hat-6.
4. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: described ether compound is selected from glycol dimethyl ether or diethylene glycol dimethyl ether.
5. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: the general formula of described quaternary ammonium compound is R
3R
4R
5R
6N
+X
-, R wherein
3Expression C1～C18 alkyl or ethene are high molecular polymer, R
4, R
5, R
6The expression alkyl, X representes halogen group.
6. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: it is the high molecular polymer trimethyl ammonium chloride that described quaternary ammonium compound is selected from Methanaminium, N,N,N-trimethyl-, fluoride, tetramethyl ammonium chloride, etamon chloride, tetraethylammonium bromide, tetrabutylammonium chloride, Tetrabutyl amonium bromide, tetrabutylammonium iodide, tetrabutylammonium perchlorate, DTAC, tetradecyl trimethyl ammonium chloride, OTAC, ethene.
7. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: described quaternary ammonium compound is selected from tetrabutylammonium chloride or Tetrabutyl amonium bromide.
8. grignard reaction according to claim 1 prepares the method for the tertiary alcohol, it is characterized in that: in the described nucleophilic addition step, Grignard reagent: ether: the add-on of quaternary ammonium salt is 1.1～3.0: 1.1～3.0: 0.1～1.0 (mol ratio).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103012061A (en) * | 2012-10-23 | 2013-04-03 | 中国科学院福建物质结构研究所 | Method for preparing chiral alcohol by taking quaternary ammonium salt as cocatalyst |
-
2012
- 2012-04-26 CN CN2012101272926A patent/CN102643163A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| HUA ZONG,ET AL.,: "Add-Metal-Free Catalytic Nucleophilic Addition of Grignard Reagents to Ketones", 《THE JOURNAL OF ORGANIC CHEMISTRY》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103012061A (en) * | 2012-10-23 | 2013-04-03 | 中国科学院福建物质结构研究所 | Method for preparing chiral alcohol by taking quaternary ammonium salt as cocatalyst |
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