CN102553440A - Liquid filtering device and filtering method thereof - Google Patents

Liquid filtering device and filtering method thereof Download PDF

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Publication number
CN102553440A
CN102553440A CN2011100642847A CN201110064284A CN102553440A CN 102553440 A CN102553440 A CN 102553440A CN 2011100642847 A CN2011100642847 A CN 2011100642847A CN 201110064284 A CN201110064284 A CN 201110064284A CN 102553440 A CN102553440 A CN 102553440A
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CN
China
Prior art keywords
runner
filtration membrane
liquid
present
blood
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CN2011100642847A
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Chinese (zh)
Inventor
林裕城
叶家显
洪家纬
陈克戎
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National Cheng Kung University NCKU
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National Cheng Kung University NCKU
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Application filed by National Cheng Kung University NCKU filed Critical National Cheng Kung University NCKU
Publication of CN102553440A publication Critical patent/CN102553440A/en
Pending legal-status Critical Current

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Abstract

The invention provides a device used for filtering a liquid. The device includes a flow channel and a filtering film. The flow channel is provided with an inlet and an outlet. The filtering film is provided with a plurality of holes. The flow channel is arranged on the filtering film in an overlapping manner. And when the liquid flows through the flow channel, the liquid contact with the filtering film. The device in the invention has a structure satisfying cross flow filtering principle. Thus, parallel shear stress can be generated by the liquid in the flow channel, thereby avoiding impurity accumulation in the holes of the filtering film.

Description

Sedimeter and filter method thereof
Technical field
The present invention is about a kind of sedimeter and filter method thereof.
Background technology
Blood is undertaken the important process of interior oxygen of organism and energy transmission, is one of indispensable element of life system normal operation.Based on this point; Clinical treatment and medical inspection field develop all that various be the application technology at center with blood; Hope to see through correctly and rapidly obtain/analyzing blood in contained cell or material, further solve the ailing discomfort of bringing, promote the human life quality.Under this theory, be regarded as one of project of giving priority to as numerous blood separation or filtering techniques that advance the rank application foundation always.
At present, the technology of known washed corpuscles and blood plasma mainly can be divided into four big types.First kind is centrifugation technique, sees through the bigger characteristic of haemocyte proportion, and whole blood blood is put in test tube, to rotate the centrifugal force that produces at a high speed, reaches the target with haemocyte and separating plasma.Yet,, cause centrifugation technique on some special applications, required purity can't be provided because the density of part haemocyte and shallow lake, Shen speed and plasma fraction are very approaching, even overlap each other.Moreover this kind technology must consume a large amount of samples and medicine usually, and processing is upward consuming time very long, and whole cost is higher.
It two is to be basic principle with the dielectrophoretic force, and the micro electronmechanical processing procedure of arranging in pairs or groups provides AC field heterogeneous with special instrument and equipment, through different electrical conductivity and dielectric constants between haemocyte and blood plasma, makes both produce separating effect.But this technology still receives the complicated and equipment needed thereby cost of step at present than condition restriction such as costlinesses, and range of application is narrow slightly.
Contactless high wavelength laser is the new technology that development in recent years goes out, and it utilizes the rightabout optical pressure to form a stable energy well, to vise fine particle.Though; At present academic theory thinks that this kind tool method is used in separating blood will possess splendid advantages such as untouchable, Noninvasive; Let contactless high wavelength laser in this field, receive very large expectation; Be difficult to overcome the too high problem of laser optics equipment cost but still have in the actual industry utilization, expanding meets with quite difficulty.
In-depth filtration is to use comparatively general person in four kinds of technology, sees through driving blood and flows through multi-layer film structure with vertical direction, makes solid matters such as haemocyte wherein be trapped in film surface.Yet the maximum problem of this kind technology is that the filter cake of film surface forms, and especially with the increase that feeds blood flow volume, inevasible corresponding the increasing of filter cake thickness meeting makes every effect a period of time just must wash and remove, and expends considerable manpower.In addition, the more important thing is that in-depth filtration tends to the haemocyte in the blood is produced bigger pressure, make and haemolysis takes place in the filter process, cause the detached job failure.
Comprehensively above-mentioned, the technology that obviously visible known technology washed corpuscles is obtained blood plasma has unavoidably that the sample consumption figure is big, instrument and equipment is expensive does not meet problems such as application cost, operation length consuming time and/or fabrication steps are loaded down with trivial details, therefore; How to provide a kind of equipment cost sedimeter cheap, simple in structure; It not only is swift in response, and required sample size is few, and running meets economic benefit; The more important thing is and effectively to avoid filter cake to form and the haemolysis generation, become an important problem.
Summary of the invention
The purpose of this invention is to provide a kind of equipment cost sedimeter cheap, simple in structure, it not only is swift in response, and required sample size is few, and running meets economic benefit, the more important thing is and can effectively avoid filter cake to form and the haemolysis generation.
The present invention can adopt following technical scheme to realize.
A kind of device that is used to filter a liquid of the present invention comprises a runner and a filtration membrane.Runner has an inflow entrance and a flow export.Filtration membrane has a plurality of holes.Wherein, runner stacks at filtration membrane, and liquid is when flowing through runner, the contact filtration film.In embodiments of the present invention, liquid in fact concurrent flow cross filtration membrane.
In one embodiment of this invention, device is a microchip.Wherein, liquid is blood, and the filtration of liquid process device obtains a blood plasma.
In embodiments of the present invention, runner shape or vortex-like in the shape of a spiral.
In embodiments of the present invention, the pore diameter range of described hole is 1 micron to 50 microns.In one embodiment of this invention, the aperture of described hole is preferably 1 micron.
In embodiments of the present invention, filtration membrane has a first surface and a second surface.Wherein, first surface has a plurality of cambered surfaces, and described hole is arranged between the said cambered surface.The corresponding described hole of second surface has a plurality of depressed areas.
In embodiments of the present invention, device comprises that also one coats housing.Runner and filtration membrane are contained in the coating housing, and the inflow entrance of runner and flow export expose to a surface that coats housing.Wherein, device also comprises a feeder.Feeder is contained in the coating housing, and corresponding runner is arranged on the opposite side of filtration membrane.Runner is connected with the hole that feeder sees through filtration membrane.
In embodiments of the present invention, coat housing and have a upper runner portion and the portion of collection once.Runner is arranged on upper runner portion, and feeder is arranged on down collection portion, and filtration membrane is folded in runner and feeder.
In an embodiment of the present invention, device also comprises an encapsulation part.Encapsulation part covers at least a portion that coats housing.
In an embodiment of the present invention, device also comprises driver element.Driver element connects runner, and drives liquid and filtration membrane relatively moves.
In addition, a kind of liquid filter method of the present invention, it sees through the device that liquid input is disclosed according to the present invention, and collects the part of said liquid through filtration membrane.In embodiments of the present invention, liquid is blood, and the part of said liquid through filtration membrane is blood plasma.
In one embodiment of this invention, liquid input unit continuously.
Hold the above, because of the structure that can see through runner and filtration membrane according to device of the present invention and filter method thereof is arranged in pairs or groups, when target liq is flow through in runner; Can contact with filtration membrane; And, provide the liquid parts in the target liq to pass through, and hold back solid matter through the small hole on the filtration membrane; Thereby reach the purpose of isolated by filtration, so applicablely comprising that the liquid that blood etc. contains suspended particulates uses.The more important thing is, because the structure of apparatus of the present invention can meet the cross-flow filtration principle for liquid with the state continuance flows of parallel filtration membrane, so can in runner, produce corresponding shear stress.So, when for example being applied in filtering blood, can effectively reduce the problem that filter cake forms, avoid hole to block and haemolysis, and be that a kind of reliability is high and do not take the blood separating mechanism of normal maintenance.
Compare with known technology, the present invention is not only simple in structure, and processing procedure is easy, can widely apply containing the liquid filtering of suspended material.In addition, produce with the mode of biochip more easily according to device of the present invention, not only have and transport advantage easily, and required sample consumption is less when operating, and helps medical place or research unit's use of each grade at every turn.Again with the angle of time cost; Utilize device of the present invention only need select the filtration membrane of cooperation, simply with the liquid input, can promptly obtain the result again; Do not have loaded down with trivial details processing procedure, avoid excessively tediously long problem of for example traditional blood separation process.
Description of drawings
Fig. 1 is the sketch map according to a kind of sedimeter of first embodiment of the invention;
Fig. 2 is the decomposing schematic representation of sedimeter shown in Figure 1;
Fig. 3 is the enlarged diagram of runner shown in Figure 2;
Fig. 4 a is the part enlarged diagram of filtration membrane shown in Figure 2;
Fig. 4 b is the sketch map of the filtration membrane shown in Fig. 4 a in hatching B-B position;
Fig. 5 is a device shown in Figure 2 sketch map in hatching A-A position;
Fig. 6 utilizes the device of first embodiment of the invention to carry out part enlarged diagram in the runner of whole blood when filtering with washed corpuscles;
Fig. 7 is the schematic representation of apparatus according to second embodiment of the invention; And
Fig. 8 is the photo figure that the result of the present invention's first experimental example observes under 10 power microscopes.
The main element symbol description:
1,7: device
11,71: coat housing
111: upper runner portion
112: following collection portion
113: the surface
12,72: runner
121,721: inflow entrance
122,722: flow export
13: feeder
14: filtration membrane
141: hole
142: first surface
143: second surface
144: cambered surface
145: the depressed area
75: driver element
76: the Teflon joint
D1: diameter
D2: width
A-A, B-B: sound upper thread
BL: blood
RC: red blood cell
C: runner
D: arrow
PL: blood platelet
SR: blood plasma
WC: white blood cell
The specific embodiment
Below will a kind of sedimeter and filter method thereof according to the preferred embodiment of the present invention be described with reference to correlative type, wherein components identical will be explained with the components identical symbol.
Fig. 1 is the sketch map according to a kind of sedimeter of first embodiment of the invention, and Fig. 2 is the decomposing schematic representation of sedimeter shown in Figure 1.Please refer to shown in Figure 1ly, a kind of device 1 according to present embodiment be used to filter a liquid, and this liquid for example contains the flowable mass of suspended particulates, particle or other small-sized solid matter.At this, 1 filtered liquid of the device of present embodiment is to be example with whole blood or the blood that contains haemocyte, wherein is suspended with the red blood cell that is referred to as haemocyte, various white blood cell and/or blood platelet.In addition; What need special instruction is; Alleged " filtration " speech means and sees through the hole both deposited in the present embodiment, with liquid through the time, with suspended particulates, particle or other small-sized solid matter of wherein appointment because the limiting factor of size; Stagnate or be trapped in an end of hole, and separate with liquid component that circulation arrives the other end of hole.In addition, the filtration that present embodiment is alleged is in no way limited in fully and separates, but contains the error that can allow on the real work of flaw, minority special status or theory because of making.
According to aforementioned definitions; The device 1 of present embodiment can for example be used for comprising that red blood cell, various white blood cell and/or hematoblastic haemocyte stagnate or be trapped in an end of hole, and separates with the blood part (being blood plasma) that does not contain haemocyte of the other end of sensible hole.Certainly, in other embodiment of the present invention, sedimeter 1 also can be used for filtering the aqueous solution that is suspended with colloidal particle, for example contains the aqueous solution of medical composition, and the present invention does not limit at this.
Please be simultaneously with reference to figure 1 and shown in Figure 2, in the present embodiment, the device 1 that is used for liquid filtering can be a micro device, miniature organism chip for example, its outward appearance is a slim cuboid.With regard to thin portion structure, device 1 comprises that one coats housing 11, a runner 12, a feeder 13 and a filtration membrane 14.Wherein, coat housing 11 and can further have a upper runner portion 111 and the portion of collection once 112.Collection portion 112 can be two blocks integrally formed or that separate under upper runner portion 111 reached, and both sizes can be identical or different.In the present embodiment, upper runner portion 111 and following collection portion 112 are two parts independently processing, but length, width and be 4 centimeters, 2.5 centimeters and 0.5 centimeter highly respectively.Upper runner portion 111 and following collection portion 112 see through sealing and combine to form coating housing 11 after formation.Certainly, except that the foregoing description, both sizes also can be with using required the adjustment, and non-is restrictive condition.
The material that coats housing 11 and upper runner portion 111 thereof and following collection portion 112 can for example be polymethyl methacrylate (Polymethylmethacrylate; PMMA), gather two methylsiloxane (Poly-dimethylsiloxane; PDMS), epoxy resin (Epoxy), metal or glass; Certainly, other macromolecular material that possesses preferable mechanical strength and high bio-compatibility characteristic also can be used.In the present embodiment, the material that coats housing 11 and upper runner portion 111 thereof and following collection portion 112 is to be example to gather pair methylsiloxanes (PDMS), and it does not have a cytotoxicity, is suitable as the material that contacts with the living body biological sample.In addition, gathering two methylsiloxanes, also to have light transmission good, characteristics such as convenient observation.
Runner 12, feeder 13 and filtration membrane 14 all are contained in and coat housing 11.Wherein, runner 12 is arranged on upper runner portion 111, and feeder 13 is arranged on down collection portion 112, and filtration membrane 14 is folded between runner 12 and the feeder 13.Runner 12 is continuous fluid paths, and to remove the bottom side be open, all the other upsides and the left and right sides totally three then be sealing.The external opening in runner 12 two ends, for example present embodiment is exposed at the surface 113 that coats housing 11 at home and abroad and rounded opening.The opening of runner 12 is respectively the inflow entrance 121 of liquid input and the flow export 122 of output; It can connect for example Teflon (polytetrafluoroethene respectively; PTFE) joint so that link with injection needle tube, avoids liquid to be filtered when coming in and going out runner 12, to leak outside again.The whole path of runner 12 does not limit shape, this with helical form or vortex-like be example, it can be in certain areal extent, forms the long fluid path of distance, helps the preferable effect of liquid filtering operation performance.Yet in other embodiments, runner 12 can also be simple straight line or zigzag, looks closely the contained composition of filtration needs and liquid, and can be really be principle with the particle of appointment or solid matter and fluid separation applications.
In the present embodiment, runner 12 is arranged on the upper runner portion 111 that coats housing 11 with the mode of encapsulating shaping.In detail, optional usefulness has gathering of mobile colloidal nature two methylsiloxanes and covers master mold, treat colloid solidification after, will gather the part that two methylsiloxanes form and separate with master mold, can form the upper runner portion 111 of the coating housing 11 that is provided with runner 12.Fig. 3 is the enlarged diagram of runner shown in Figure 2.Please refer to shown in Figure 3ly, runner 12 is arranged on the center of upper runner portion 111, and runner 12 integral body (to call the cross-flow district in the following text) summary shape or vortex-like in the shape of a spiral.Cross-flow district diameter d 1 about 0.8 centimeter.The channel width d2 of runner 12 is 50 microns approximately, and the structure height of runner is 100 microns approximately.Certainly; The all non-restrictive condition of the present invention of above-mentioned size, and can need adjustment with practical application, in other embodiments; The channel width d2 of runner 12 can be from about 50 to 500 microns; They for example be 100 or 200 microns, and the structure height of runner 12 can be from about 10 to 500 microns, and for example 20 or 200 microns.In addition, in the process that runner 12 forms, make the upper runner portion 111 that coats housing 11 form the inflow entrance 121 and flow export 122 of external opening through for example Mould design simultaneously, at this, both all are slender tube body (not showing among Fig. 3).
Please refer to shown in Figure 2ly, the feeder 13 of present embodiment can also be arranged on down collection portion 112 according to above-mentioned same way as, and corresponding runner 12 is arranged on the opposite side of filtration membrane 14.Wherein, feeder 13 can be the circular groove of 0.8 centimeter of a diameter, and structure height is 200 microns.Certainly, the size of feeder 13 also can be adjusted with the amount of for example filter liquide, and in other embodiments, its structure height can be between 10 to 500 microns, and for example, structure height can be 20 or 200 microns.
In the present embodiment; Cross-flow district, feeder 13 and filtration membrane 14 threes' center can for example overlap in fact; And filtration membrane 14 is folded in 13 of runner 12 and feeders, and in other words, filtration membrane 14 can be folded in upper runner portion 111 and 112 in collection portion down.The size of filtration membrane 14 and configuration do not have special restriction, are principle to cooperate the cross-flow district in principle.
Fig. 4 a is the part enlarged diagram of filtration membrane shown in Figure 2, and Fig. 4 b is the sketch map of the filtration membrane shown in Fig. 4 a in hatching B-B position.Please be simultaneously with reference to shown in figure 4a and Fig. 4 b, in the present embodiment, filtration membrane 14 can be the circular membrane of 1 centimeter of diameter, has a plurality of holes 141 on it.Filtration membrane 14 has a first surface 142 and a second surface 143, and it is respectively the upper surface and the lower surface of filtration membrane 14.In the present embodiment, all approximate flat surface of the first surface 142 of the filtration membrane 14 that macroscopic is observed down and second surface 143, and no concave-convex fluctuations (as shown in Figure 2).Yet, please refer to shown in Fig. 4 b, if further observe with microcosmic angle, first surface 142 has a plurality of cambered surfaces that raise up 144, and hole 141 is arranged between the cambered surface 144, and second surface 143 corresponding holes 141, have a plurality of depressed areas 145.
Put off until some time later bright said structure in detail.Please be simultaneously with reference to shown in figure 4a and Fig. 4 b, in the present embodiment, cambered surface 144 can for example be an arc surface, and comprises top and bottom, the bottom is arranged on the periphery of hole 141.Depressed area 145 can be circular, and area is greater than the area of hole 141.In addition, hole 141 is the circular perforations that are communicated with first surface 142 to the second surface 143 of filtration membrane 14, and its diameter can for example be 1 micron.So in other embodiment of the present invention, hole 141 can also be other shape and/or size, and for example from 1 to 50 micron is according to the size of the composition of target solution and selected suspended particulates that filter or solid matter and adjust in principle.For example, be example with the haemocyte in the isolated by filtration whole blood, the preferable diameter of hole 141 is 1 micron.
Filtration membrane 14 can be the alloy material, and its manufacturing can see through and comprise that lithographic process and electroforming (electroforming) wait several steps.At first, a substrate can be provided earlier, on a surface of substrate, form a photoresist layer then.Continue, form a plurality of photoresistance patterns, and appear the part surface of substrate at photoresist layer.One light shield is set above photoresist layer, wherein, light shield has the pattern of a plurality of corresponding photoresistance patterns., make public and develop, to form the circular photoresistance pattern shown in the present embodiment thereafter.Utilize electrocasting that one alloy-layer is formed on photoresistance pattern and the substrate.At last, alloy-layer and photoresistance pattern and substrate are separated, promptly formed the filtration membrane 14 of present embodiment.
Fig. 5 is a device shown in Figure 1 sketch map in hatching A-A position.Please refer to shown in Figure 5; In the present embodiment; Because runner 12 is parallel in fact to stack on the first surface 142 of filtration membrane 14; Therefore when liquid L feeds and flows through runner 12, contact with filtration membrane 14 during must having partly, and be that mode with parallel in fact filtration membrane 14 flows through filtration membrane 14 tops.Runner 12 is open configuration through bottom side own; And be connected with hole 141 that feeder 13 sees through filtration membrane 14, be with, when liquid L flows in runner 12; Can receive the gravity effect and flow to hole 141 (among the figure because the macroscopic angle by the cambered surface 144 of first surface 141; So still flat, detailed structure can be with reference to Fig. 4 b), the part that makes liquid is smoothly through hole 141; The solid matter that surpasses hole 141 sizes as for for example particulate contained among the liquid L wherein or granular size all can be held back by hole 141, reaches the effect of separating and filtering.
What be worth special instruction is; Through device 1 structure of the present invention; Can make liquid L meet the principle of cross-flow filtration, produce the parallel shears shearing stress, thereby for example be deposited in the particulate of the first surface 142 of filtration membrane 14 or the solid matter that granular size surpasses hole 141 sizes in the cleaning filter process; Avoid the rate of filtration to receive and be filtered the influence that material is piled up on the hole 141, cause the increase of operation resistance.For producing preferable parallel shears shearing stress and filter effect, the flow rates of liquid L is approximately from 0.05mL/min to 0.5mL/min, and is wherein better with the obtainable filter effect of higher flow velocity again, for example with 0.5mL/min.
Fig. 6 utilizes the device of first embodiment of the invention to carry out part enlarged diagram in the runner of whole blood when filtering with washed corpuscles.Please refer to shown in Figure 6ly, when being used in particular for whole blood and filtering, see through design of the present invention with washed corpuscles; Blood BL can flow in runner 12 with the mode of parallel filtration membrane 14; And according to above-mentioned principle, white blood cell WC, red blood cell RC and blood platelet PL are separated with blood plasma SR, accomplish the purpose of collecting blood plasma SR; Can also effectively reduce simultaneously the formation of filter cake, prevent and block and haemolysis.
Fig. 7 is the schematic representation of apparatus according to second embodiment of the invention.Please refer to shown in Figure 7ly, in the present embodiment, structure and the assembly that is used for the device 7 of liquid filtering formed roughly said identical with previous embodiment, thus below only with regard to not mentioned part explanation still.The device 7 of present embodiment also comprises a driver element 75, circulates in runner 72 in order to power drive liquid to be provided.Wherein, driver element 75 connects the inflow entrance 721 of runner 72, preferably sees through Teflon joint 76 and is connected with inflow entrance 721, and be arranged on the upside that coats housing 71.Driver element 75 can be for example with miniature injection group Pu, start that the back is sustainable will to promote forward from the liquid of external connection type memory apparatus (figure does not show) input unit 7, and make it keep inertia to advance, thereby form and the relatively moving of 74 of filtration membranes.According to this condition; Driver element 75 certainly is other module or assembly that power can be provided; For example aspirator, manual operation injection needle tube or other similar installation; Also or at inflow entrance 721 and flow export 722 form gas pressure difference or vacuum state, module or assembly that liquid can be pushed.
What need explain in addition is, can utilize encapsulation technology to coat in addition and protect according to device of the present invention, and for example, in third embodiment of the invention, device has structure and the assembly composition roughly the same with previous embodiment, and also comprises an encapsulation part.Encapsulation part is an encapsulating material with macromolecular material epoxy resin (Epoxy), and covers at least a portion that coats housing, for example coats the upper surface of housing.
The present invention discloses a kind of filter method in addition, and it imports aforementioned device of the present invention with liquid, with the particulate in the separating liquid, particle or solid matter, regathers through the part of liquid through filtration membrane.For example, filter method of the present invention can be used for blood is imported continuously, with the haemocyte in the filtering blood, collects blood through the blood plasma part behind the filtration membrane.
For checking apparatus of the present invention and filter method thereof are feasible, below be an experimental example with successful candidate in the imperial examinations at the provincial level in the Ming and Qing dynasties's class blood, the haemocyte in description operation apparatus of the present invention separating blood, and the step of collecting blood plasma.
Experimental example 1 utilizes apparatus of the present invention to filter blood of human body
According to apparatus of the present invention that aforementioned manner is processed, be a kind of miniature organism chip at this.At first, measure human whole blood blood 0.5mL with the 1mL syringe.Utilize the Teflon joint to link injection needle tube whole blood blood is injected apparatus of the present invention.Adjustment micro-injection group Pu maintains in the scope of 0.05mL/min to 0.5mL/min flow velocity.Setting at the array flow velocity of this use can be 0.5mL/min, 0.3mL/min, 0.1mL/min, 0.07mL/min and 0.05mL/min.In continuing to import about 10 minutes is that injectable finishes.Through the observation by light microscope filter result, as shown in Figure 8, under 10 power microscopes, can be observed blood circulation runner C, and the situation (like arrow D indication) of separating with haemocyte through filtration membrane generation blood plasma.
In sum, because of the structure that can see through runner and filtration membrane according to device of the present invention and filter method thereof is arranged in pairs or groups, when target liq is flow through in runner; Can contact with filtration membrane; And, provide the liquid parts in the target liq to pass through, and hold back solid matter through the small hole on the filtration membrane; Thereby reach the purpose of isolated by filtration, use so can be adapted at comprising the liquid that blood etc. contains suspended particulates.The more important thing is, because the structure of apparatus of the present invention can meet the cross-flow filtration principle for liquid with the state continuance flows of parallel filtration membrane, so can in runner, produce corresponding shear stress.So, when for example being applied in filtering blood, can effectively reduce the problem that filter cake forms, avoid hole to block and haemolysis, and be that a kind of reliability is high and do not take the blood separating mechanism of normal maintenance.
Compare with known technology, the present invention is not only simple in structure, and processing procedure is easy, can widely apply containing the liquid filtering of suspended material.In addition, produce with the mode of biochip more easily according to device of the present invention, not only have and transport advantage easily, and required sample consumption is less when operating, and helps medical institutes or research unit's use of each grade at every turn.Again with the angle of time cost; Utilize device of the present invention only need select the filtration membrane of cooperation, simply with the liquid input, can promptly obtain the result again; Do not have loaded down with trivial details processing procedure, avoid excessively tediously long problem of for example traditional blood separation process.
The above only is an illustrative, and non-limiting.Anyly do not break away from spirit of the present invention and category, and, all should be included in the claim institute restricted portion its equivalent modifications of carrying out or change.

Claims (10)

1. a device is used to filter a liquid, it is characterized in that, said device comprises:
One runner has an inflow entrance and a flow export; And
One filtration membrane has a plurality of holes,
Wherein, said runner stacks at said filtration membrane, and said liquid contacts said filtration membrane when flowing through said runner.
2. device according to claim 1 is characterized in that, also comprises:
One coats housing, and said runner and said filtration membrane are contained in said coating housing, and said inflow entrance and said flow export expose to a surface of said coating housing.
3. device according to claim 2 is characterized in that, also comprises:
One feeder is contained in said coating housing, and corresponding said runner is arranged on the opposite side of said filtration membrane.
4. device according to claim 3 is characterized in that, said runner is connected with the described hole that said feeder sees through said filtration membrane.
5. device according to claim 3; It is characterized in that said coating housing has a upper runner portion and the portion of collection once, said runner is arranged on said upper runner portion; Said feeder is arranged on said collection portion down, and said filtration membrane is folded in said runner and said feeder.
6. device according to claim 2 is characterized in that, also comprises:
One encapsulation part covers at least a portion of said coating housing.
7. device according to claim 1 is characterized in that said runner is shape or vortex-like in the shape of a spiral.
8. device according to claim 1 is characterized in that, said filtration membrane has a first surface and a second surface; Said first surface has a plurality of cambered surfaces; Described hole is arranged between the said cambered surface, and the corresponding described hole of said second surface, has a plurality of depressed areas.
9. device according to claim 1 is characterized in that, the pore diameter range of described hole is 1 micron to 50 microns.
10. a liquid filter method is characterized in that, sees through liquid input like each device of claim 1 to 9, and collects the part of said liquid through said filtration membrane.
CN2011100642847A 2010-12-24 2011-03-17 Liquid filtering device and filtering method thereof Pending CN102553440A (en)

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