CN102552946A - Double-mode imaging and medicine-loading integrated nano medicine carrier and preparation method thereof - Google Patents
Double-mode imaging and medicine-loading integrated nano medicine carrier and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a double-mode imaging and medicine-loading integrated nano medicine carrier and a preparation method thereof. The nano medicine carrier is characterized in that nanoparticles are formed by wrapping functional nanocrystal and anti-tumor medicines through using biodegradable macromolecular polymers; the size of the nano medicine carrier is less than 500 nm; and the nano medicine carrier has a smooth surface and is regular in particle size. The nano medicine carrier is prepared by at least one of a precipitation method, a micellar method and a microemulsion method. The microemulsion method comprises the following steps of: preparing the functional nanocrystal, the anti-tumor medicines and the biodegradable macromolecular polymers into liquid respectively; mixing and stirring to form microemulsion; and curing nanospheres with stirring, centrifugally separating the nanospheres, cleaning and freeze-drying to prepare the double-mode imaging and medicine-loading integrated nano medicine carrier. According to the technical scheme, double functions of tumor fluorescence diagnosis and magnetic resonance imaging of the nano medicine carrier are realized; sustained release of the medicines and targeted medicine supply are realized; and toxic or side effect and damage to the normal tissue caused by high-dose multiple administration are greatly reduced.
Description
Technical field
The present invention relates to a kind of nano-medicament carrier and use and preparation method thereof, relate in particular to a kind of can be simultaneously with the material of double mode imaging and nano-medicament carrier of antitumor drug carrying and preparation method thereof.
Background technology
At biomedical sector; Development collection high spatial resolution, high sensitivity and AT image technology have become the focus of nano biological medical domain research, and the image technology that is applied to clinical diagnose at present comprises: X ray computer fault imaging (CT), positron emission tomography, nuclear magnetic resonance etc.Yet; The spatial resolution of these medical image technology still can't satisfy people's demand; And the character of image quality and contrast agent is closely related; Therefore develop multimodal medical imaging technology, the sensitivity and the spatial resolution that how to improve medical image still become a research work that has much challenge.As everyone knows; The fluorescence imaging technology has high sensitivity; As fluorescence imaging and these two kinds of imaging means of nuclear magnetic resonance are combined the double mode imaging system of formation; Will improve the sensitivity and the resolution of imaging, wherein as the magneto-optic Composite Double mode imaging system of nuclear magnetic resonance material report arranged, as fluorescent materials such as magnetic oxide and fluorescent dye or quantum dot are assembled into the magneto-optic composite with ultra paramagnetic iron oxide.But fluorescent dye is prone to bleach, and instability can not be eliminated background fluorescence when in cell and tissue, using, and the cytotoxicity of quantum dot is bigger, and these shortcomings seriously hinder the diagnosis that this system is applied to tumor.In addition, this magneto-optic compound system only is used for the diagnosis of tumor, and does not have the function of oncotherapy.Clinically, chemotherapy remains the important means of oncotherapy.Because the traditional tumour chemicals does not have targeting property, can not concentrate on the position at tumor place relatively, therefore in the kill tumor cell, also damage normal cell, and followed fierce immunogenicity, thereby caused serious toxic and side effects.Along with the development of nanotechnology, nano-medicament carrier is widely used in medical domain owing to have characteristics such as bigger serface, small size and easy modification chemical molecular.Nano-medicament carrier has the prolong drug half-life, reduces advantages such as immunogenicity, the dissolubility that improves insoluble medicine and cell absorbance, helps to improve curative effect of medication and reduces toxic and side effects.
For toxic and side effects that reduces medicine and the drug level that improves tumor tissues; Use the Biodegradable polymer material packaging medicine, process medicament-carried nano granule, carry out finishing through the size of control nano particle diameter and to it with slow releasing function; Make it discern tumor tissues by targeting; And orientation discharges antitumor drug, thereby when improving curative effect, does not influence the effect of normal structure, can alleviate toxicity greatly.Therefore, double mode imaging technique and chemotherapy are combined, realize the diagnosis and treatment engineering of integrating of tumor, aspect the diagnosis of tumor and the treatment prospect will arranged very.
Summary of the invention
In the prospect of above-mentioned expection, the object of the invention aims to provide a kind of nano-medicament carrier and method for making thereof that collects double mode imaging and medicine carrying, solves the problem of single medicine carrier multifunction.
In order to solve above technical problem; The present invention proposes a kind of nano-medicament carrier that collects double mode imaging and medicine carrying; It is characterized in that: said nano-medicament carrier is nanoparticle brilliant by Biodegradable high-molecular polymer parcel function nano and that antitumor drug constitutes, and the size of said nano-medicament carrier is less than 500nm, smooth surface and particle diameter rule; Wherein said function nano is brilliant in possessing luminous and the nano crystal material nuclear magnetic resonance function.
Further, said Biodegradable high-molecular polymer is at least polylactic acid, polylactic acid-glycolic guanidine-acetic acid copolymer; Poly-epsilon-caprolactone, chitosan, alginate; PTMC, gelatin, polyethylene glycol oxide; PPDO, and the copolymer of those monomer-polymers and one of ethylene glycol, vinylamine or beta-schardinger dextrin-anhydride also comprise dimer or trimer between each polymer monomer simultaneously; And each high molecular polymer end all contains the active group carboxyl, amino, at least a in hydroxyl and the sulfydryl.
Further, in the said polylactic acid-glycolic guanidine-acetic acid copolymer ratio of monomer lactic acid/glycolic between 50:50～85:15.
Further, said function nano crystalline substance is at least the rare earth doped fluoride of gadolinium ion, the rare earth doped oxide of gadolinium ion, Fe
3O
4, γ-Fe
2O
3A kind of with in the fluorescence quantum.
Further, said antitumor drug is water solublity or hydrophobic molecular medicine, includes amycin, paclitaxel; Cisplatin and derivant thereof, docetaxel, epirubicin, gemcitabine; Vinorebine, pirarubicin, capecitabine, one or more in the hydroxy camptothecin etc.
The present invention also proposes a kind of nano-medicament carrier method for making for preparing double mode imaging of above-mentioned collection and medicine carrying; It is characterized in that: adopt to comprise the sedimentation method at least; A kind of method in micelle assay and the microemulsion method prepares; Wherein said microemulsion method is for making liquid respectively with function nano crystalline substance, antitumor drug and Biodegradable high-molecular polymer; Warp mixes, stirs the formation emulsion, processes double-mode integrated nano-medicament carrier through stirring curing nano ball, centrifugalize nanosphere, cleaning, lyophilization again.
Further, said microemulsion method comprises two types of oil/aqueous systems and water/oil/aqueous systems according to the lipophile of antitumor drug and hydrophilic difference, and corresponding oil loving antitumor drug is selected oil/aqueous systems for use; Corresponding hydrophilic antitumor drug is selected water/oil/aqueous systems for use, or earlier antitumor drug is extracted in the oil phase, selects oil/aqueous systems again for use.
Further, in the said system liquid used liquor for comprising organic facies, water and surfactant mixtures.
Further, said surfactant is at least sodium lauryl sulphate, dodecyl sodium sulfate; Dodecylbenzene sodium sulfonate, cetyl trimethyl ammonium bromide, sodium cholate; Polyvinyl alcohol, Pluronic F127, Pluronic F68; Gelatin, a kind of in tween 80 plasma type and the nonionic surfactant.
Further, said organic solvent is a dichloromethane, chloroform, acetonitrile and with the mixed solvent of ethyl acetate, acetone, dimethyl formamide or oxolane in any one or a few.
The proposition of technical scheme of the present invention and enforcement; Compare to prior art and have outstanding beneficial effect: through select for use suitable contrast agent and targetedly antitumor drug in same nano-medicament carrier, realize integrated loading; Can realize the dual-use function of disease fluorescence diagnosis and nuclear magnetic resonance; Slow release and the targeting of realizing medicine simultaneously supplies the accuracy of medicine, greatly reduces toxic and side effects that heavy dose of multiple dosing brings and to the infringement of normal structure.In addition, it is simple, with low cost that the present invention's preparation also has technology, is suitable for the outstanding advantage of industrial mass manufacture.
Description of drawings
Fig. 1 is that (UCNPs is up-conversion luminescence nano-particle NaGdF4:Yb to the nanosphere PLGA-UCNPs-Dox with double mode imaging and chemotherapy function for preparing of the present invention, electron scanning micrograph Er).
Fig. 2 is the transmission electron microscope photo of the nanosphere PLGA-UCNPs-Dox with double mode imaging and chemotherapy function for preparing of the present invention.
Fig. 3 is the transmission electron microscope photo of the nanosphere PLGA-UCNPs-PTX with double mode imaging and chemotherapy function for preparing of the present invention.
Fig. 4 is the histogram of particle size distribution of product embodiment illustrated in fig. 1.
Fig. 5 is the emission spectra of product embodiment illustrated in fig. 1 under the 980nm light source activation.
Fig. 6 be product embodiment illustrated in fig. 1 and isocyatic amycin, non-drug the fluorescence spectrum of nanosphere under the 490nm light source activation relatively.
Fig. 7 is the nuclear magnetic resonance figure of product embodiment illustrated in fig. 1 under variable concentrations.
The specific embodiment
Creator of the present invention is through concentrating on studies for many years, and to the nano-medicament carrier limitation on the function and the deficiency of practical application effect in the past, innovation proposes a kind of nano-medicament carrier and method for making thereof that collects double mode imaging and medicine carrying.Summarizing each item technical characterictic of this technical scheme can recognize: this nano-medicament carrier is nanoparticle brilliant by Biodegradable high-molecular polymer parcel function nano and that antitumor drug constitutes, and the size of nano-medicament carrier is less than 500nm, smooth surface and particle diameter rule; Wherein function nano is brilliant in possessing luminous and nano crystal materials two kinds of imaging pattern integrated functionalities of magnetic resonance.Adopt on the method for preparing and comprise the sedimentation method at least; A kind of method in micelle assay and the microemulsion method prepares; Wherein said microemulsion method is for making liquid respectively with function nano crystalline substance, antitumor drug and Biodegradable high-molecular polymer; Warp mixes, stirs the formation emulsion, processes double-mode integrated nano-medicament carrier through stirring curing nano ball, centrifugalize nanosphere, cleaning, lyophilization again.
From optimizing optional raw material; Wherein the Biodegradable high-molecular polymer is at least polylactic acid (PLA), polylactic acid-glycolic guanidine-acetic acid copolymer (PLGA), poly-epsilon-caprolactone (PCL), chitosan, alginate, PTMC (TPMC), gelatin, polyethylene glycol oxide (PEO), PPDO (PDO); And the copolymer of those monomer-polymers and one of ethylene glycol, vinylamine or beta-schardinger dextrin-anhydride; Also comprise dimer or trimer between each polymer monomer simultaneously, like the copolymer of the copolymer of chitosan-copolymer of poly lactic acid, chitosan-polycaprolactone, cyclodextrin-copolymer of poly lactic acid, cyclodextrin-polycaprolactone, PEG-PCL-PEG, PEI-PCL-PEI, PEG-PLA-PEG, PEI-PLA-PEI, PEG-PCL-PEI, PEG-PLA-PEI etc.; And each high molecular polymer end all contains at least a in active group carboxyl, amino, hydroxyl and the sulfydryl.The ratio of monomer lactic acid/glycolic is between 50:50～85:15 in the polylactic acid-glycolic guanidine-acetic acid copolymer in special this Biodegradable high-molecular polymer.This base polymer is degradable in vivo; And catabolite is to the human non-toxic side effect; Can excrete with the body metabolism system, in addition, the active group of such polymer ends is the targeted molecular of coupling tumor markers further; Targeting reduces the toxic and side effects of medicine greatly in tumor tissues.
Wherein the function nano crystalline substance is at least rare earth doped fluoride, the rare earth doped oxide of gadolinium ion, the Fe of gadolinium ion
3O
4, γ-Fe
2O
3A kind of with in the fluorescence quantum.
Wherein antitumor drug is water solublity or hydrophobic molecular medicine, includes in amycin, paclitaxel, cisplatin and derivant thereof, docetaxel, epirubicin, gemcitabine, Vinorebine, pirarubicin, capecitabine, the hydroxy camptothecin etc. one or more.
Launch from preferred microemulsion method, comprise two types of oil/aqueous systems and water/oil/aqueous systems according to the lipophile of antitumor drug and hydrophilic difference, corresponding oil loving antitumor drug is selected oil/aqueous systems for use; Corresponding hydrophilic antitumor drug is selected water/oil/aqueous systems for use, or earlier antitumor drug is extracted in the oil phase, selects oil/aqueous systems again for use.
Wherein make the used liquor of liquid for comprising organic facies, water and surfactant mixtures.This surfactant is at least in sodium lauryl sulphate (SDS), dodecyl sodium sulfate (SBS), dodecylbenzene sodium sulfonate (SDBS), cetyl trimethyl ammonium bromide (CTAB), sodium cholate, polyvinyl alcohol (PVA), Pluronic F127, Pluronic F68, gelatin, tween 80 plasma type and the nonionic surfactant a kind of; This organic solvent is a dichloromethane, chloroform, acetonitrile and with the mixed solvent of ethyl acetate, acetone, dimethyl formamide (DMF) or oxolane (THF) in any one or a few.
Below embodiments of the invention are elaborated.Those embodiment provided detailed embodiment and concrete operating process, but protection scope of the present invention are not limited to following embodiment being to implement under the prerequisite with technical scheme of the present invention.
Embodiment 1:Doxorubicin hydrochloride is water-soluble, add a spot of triethylamine amycin is extracted to dichloromethane.Again with the polylactic acid-glycolic guanidine-acetic acid copolymer of carboxyl terminal (hereinafter to be referred as PLGA, its Mw=10000, LA:GA=75:25) with up-conversion luminescence nanometer crystal NaGdF4:Yb, Er is dissolved in the dichloromethane respectively.Respectively get a certain amount of three kinds of solution and be made into the 1ml dichloromethane solution; Make the PLGA that wherein is dissolved with 8mg, the NaGdF4:Yb of 4 mg, Er and 500 μ g amycin drop to 10ml with this dichloromethane solution and contain in the aqueous solution of 1% PVA; Under 16000rpm, stir 10min; Form stable O/W emulsion, gentle agitation 6h volatilization dichloromethane under 40 ℃ of water-baths again, curing nano ball.With the centrifugal collection of the nanosphere in the suspension and with secondary redistilled water washing several, lyophilization gets the function nano pharmaceutical carrier.
Embodiment 2:(Mw=10000, LA:GA=75:25) with up-conversion luminescence nanometer crystal NaGdF4:Yb, Er is dissolved in the dichloromethane respectively with the PLGA of paclitaxel, carboxyl terminal.Respectively get a certain amount of three kinds of solution and be made into the 1ml dichloromethane solution; Make the PLGA that wherein is dissolved with 8mg, the NaGdF4:Yb of 4mg, Er and 500 μ g paclitaxels inject the aqueous solution that 10ml contains 1% PVA with this dichloromethane solution; 16000rpm stirs 10min down; Form stable O/W emulsion, gentle agitation 6h volatilization dichloromethane under 40 ℃ of water-baths again, curing nano ball.With the centrifugal collection of the nanosphere in the suspension and with secondary redistilled water washing several, lyophilization gets the function nano pharmaceutical carrier.
Embodiment 3:(Mw=10000, LA:GA=75:25) with up-conversion luminescence nanometer crystal NaGdF4:Yb, Er is dissolved in the dichloromethane respectively with the PLGA of paclitaxel, carboxyl terminal.Respectively get a certain amount of three kinds of solution and be made into the 1ml dichloromethane solution, make the PLGA that wherein is dissolved with 8mg, the NaGdF4:Yb of 4mg, Er and 500 μ g paclitaxels.The SDS that takes by weighing 56mg is dissolved in the 10ml deionized water, then this 1ml dichloromethane solution is injected in the aqueous solution of SDS, and 16000rpm stirs down 10min, forms stable O/W emulsion, the gentle agitation volatilization dichloromethane that spends the night again, curing nano ball.With the centrifugal collection of the nanosphere in the suspension and with secondary redistilled water washing several, lyophilization gets the compound PLGA nanosphere of function.
Above-mentioned a plurality of embodiment is intended to be convenient to understand technical characterictic of the present invention.So that those skilled in the art can know the innovation essence of grasping technical scheme of the present invention, be not the embodiment that only on function or properties of product, proposes qualification.So except that the foregoing description, the present invention can also have other polynary embodiment.All employings are equal to the technical scheme of replacement or equivalent transformation formation, all drop on the protection domain of requirement of the present invention.
Claims (10)
1. the nano-medicament carrier of a collection double mode imaging and medicine carrying; It is characterized in that: said nano-medicament carrier is nanoparticle brilliant by Biodegradable high-molecular polymer parcel function nano and that antitumor drug constitutes, and the size of said nano-medicament carrier is less than 500nm, smooth surface and particle diameter rule; Wherein said function nano is brilliant in possessing luminous and the nano crystal material nuclear magnetic resonance function.
2. a kind of nano-medicament carrier that collects double mode imaging and medicine carrying as claimed in claim 1 is characterized in that: said Biodegradable high-molecular polymer is at least polylactic acid, polylactic acid-glycolic guanidine-acetic acid copolymer; Poly-epsilon-caprolactone, chitosan, alginate; PTMC; Gelatin, polyethylene glycol oxide, PPDO; And the copolymer of those monomer-polymers and one of ethylene glycol, vinylamine or beta-schardinger dextrin-anhydride, also comprise dimer or trimer between each polymer monomer simultaneously; And each high molecular polymer end all contains at least a in active group carboxyl, amino, hydroxyl, the sulfydryl.
3. a kind of nano-medicament carrier that collects double mode imaging and medicine carrying as claimed in claim 2 is characterized in that: the ratio of monomer lactic acid/glycolic is between 50:50～85:15 in the said polylactic acid-glycolic guanidine-acetic acid copolymer.
4. a kind of nano-medicament carrier that collects double mode imaging and medicine carrying as claimed in claim 1 is characterized in that: said function nano crystalline substance is at least the rare earth doped fluoride of gadolinium ion, the rare earth doped oxide of gadolinium ion, Fe
3O
4, γ-Fe
2O
3A kind of with in the fluorescence quantum.
5. a kind of nano-medicament carrier that collects double mode imaging and medicine carrying as claimed in claim 1 is characterized in that said antitumor drug is water solublity or hydrophobic molecular medicine, includes amycin; Paclitaxel, cisplatin and derivant thereof, docetaxel; Epirubicin, gemcitabine, Vinorebine; Pirarubicin, capecitabine, one or more in the hydroxy camptothecin.
6. the method for making of the nano-medicament carrier of a collection double mode imaging and medicine carrying; It is characterized in that: adopt to comprise the sedimentation method at least; A kind of method in micelle assay and the microemulsion method prepares; Wherein said microemulsion method is for making liquid respectively with function nano crystalline substance, antitumor drug and Biodegradable high-molecular polymer, and warp mixes, stirring forms emulsion, and double-mode integrated nano-medicament carrier is processed in warp stirring curing nano ball, centrifugalize nanosphere, cleaning, lyophilization again.
7. a kind of nano-medicament carrier method for making that collects double mode imaging and medicine carrying as claimed in claim 6; It is characterized in that: said microemulsion method comprises two types of oil/aqueous systems and water/oil/aqueous systems according to the lipophile of antitumor drug and hydrophilic difference, and corresponding oil loving antitumor drug is selected oil/aqueous systems for use; Corresponding hydrophilic antitumor drug is selected water/oil/aqueous systems for use, or earlier antitumor drug is extracted in the oil phase, selects oil/aqueous systems again for use.
8. a kind of nano-medicament carrier method for making that collects double mode imaging and medicine carrying as claimed in claim 6, it is characterized in that: used liquor is for comprising organic facies, water and surfactant mixtures in the said system liquid.
9. a kind of nano-medicament carrier method for making that collects double mode imaging and medicine carrying as claimed in claim 8 is characterized in that said surfactant is at least sodium lauryl sulphate; Dodecyl sodium sulfate, dodecylbenzene sodium sulfonate, cetyl trimethyl ammonium bromide; Sodium cholate, polyvinyl alcohol, Pluronic F127; Pluronic F68, gelatin, a kind of in tween 80 ion-type and the nonionic surfactant.
10. a kind of nano-medicament carrier method for making that collects double mode imaging and medicine carrying as claimed in claim 8; It is characterized in that; Said organic solvent is a dichloromethane, chloroform, acetonitrile and with the mixed solvent of ethyl acetate, acetone, dimethyl formamide or oxolane in any one or a few.
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Cited By (13)
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| CN103055323A (en) * | 2012-12-20 | 2013-04-24 | 华南理工大学 | Capecitabine medicine carrier and preparation method thereof |
| CN103275722A (en) * | 2013-06-20 | 2013-09-04 | 南京大学 | Magneto-optical bimodal imaging probe rare earth nanoparticle, and preparation method and application thereof |
| CN107224753A (en) * | 2017-07-17 | 2017-10-03 | 江苏理工学院 | A kind of method of utilization Magnetic solid phases extraction sorbing material enrichment detection camptothecine |
| CN107629202A (en) * | 2017-09-01 | 2018-01-26 | 天津科技大学 | A kind of poly- polysaccharide of ring improves the hydrophilic method of PPDO and application |
| CN110740750A (en) * | 2017-03-15 | 2020-01-31 | 纳米技术有限公司 | Photo-responsive quantum dot drug delivery system |
| CN111632154A (en) * | 2020-06-01 | 2020-09-08 | 湖北科技学院 | Phase-transition nanobubble, preparation method and application thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631362A (en) * | 2004-11-26 | 2005-06-29 | 中国科学院上海药物研究所 | Anti cancer sustained releasing composition and its preparation method |
| CN102350277A (en) * | 2011-06-16 | 2012-02-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof |
-
2012
- 2012-03-01 CN CN2012100508039A patent/CN102552946A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631362A (en) * | 2004-11-26 | 2005-06-29 | 中国科学院上海药物研究所 | Anti cancer sustained releasing composition and its preparation method |
| CN102350277A (en) * | 2011-06-16 | 2012-02-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | Composite microballoon with functions of dual mode imaging and photodynamic activity and preparation method thereof |
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| CN103055323A (en) * | 2012-12-20 | 2013-04-24 | 华南理工大学 | Capecitabine medicine carrier and preparation method thereof |
| CN103275722A (en) * | 2013-06-20 | 2013-09-04 | 南京大学 | Magneto-optical bimodal imaging probe rare earth nanoparticle, and preparation method and application thereof |
| CN103275722B (en) * | 2013-06-20 | 2016-08-10 | 南京大学 | A kind of magneto-optic bimodal image probe rare earth nanoparticle and preparation method thereof and purposes |
| CN110740750A (en) * | 2017-03-15 | 2020-01-31 | 纳米技术有限公司 | Photo-responsive quantum dot drug delivery system |
| CN107224753A (en) * | 2017-07-17 | 2017-10-03 | 江苏理工学院 | A kind of method of utilization Magnetic solid phases extraction sorbing material enrichment detection camptothecine |
| CN107224753B (en) * | 2017-07-17 | 2019-07-23 | 江苏理工学院 | A method of utilizing Magnetic solid phases extraction adsorbent material enrichment detection camptothecine |
| CN107629202A (en) * | 2017-09-01 | 2018-01-26 | 天津科技大学 | A kind of poly- polysaccharide of ring improves the hydrophilic method of PPDO and application |
| CN111632154A (en) * | 2020-06-01 | 2020-09-08 | 湖北科技学院 | Phase-transition nanobubble, preparation method and application thereof |
| CN111688317A (en) * | 2020-06-28 | 2020-09-22 | 四川汇利实业有限公司 | Preparation method of medicinal packaging composite material |
| CN111731671A (en) * | 2020-06-28 | 2020-10-02 | 四川汇利实业有限公司 | Composite material for liquid medicine packaging bag |
| CN111904945A (en) * | 2020-08-25 | 2020-11-10 | 上海健康医学院 | Oral administration system of nano suspension, construction method and application thereof |
| CN111904945B (en) * | 2020-08-25 | 2023-07-21 | 上海健康医学院 | Oral administration system of nano suspension, construction method and application thereof |
| CN112263566A (en) * | 2020-09-24 | 2021-01-26 | 中国药科大学 | Albumin-binding type anoxic-oxidation dual-responsiveness composite nanoparticle, preparation method and application |
| CN112546224A (en) * | 2020-12-22 | 2021-03-26 | 暨南大学 | Preparation method of bimodal non-small cell lung cancer targeted nanoprobe based on ultra-small magnetic nanoparticles |
| CN115825442A (en) * | 2021-11-23 | 2023-03-21 | 中国人民解放军总医院第一医学中心 | Application of perovskite nanocrystalline in preparation of probe for tumor diagnosis or treatment |
| CN117771420A (en) * | 2024-02-26 | 2024-03-29 | 苏州大学 | Polylactic acid-glycolic acid copolymer microsphere and application thereof |
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Application publication date: 20120711 |