CN102552758B - Decoction containing Semen plantaginis, Philippine Violet Herb and Chinese lobelia for chronic pelvic inflammatory disease - Google Patents

Abstract

The invention, relating to the field of drug formula, particularly discloses a decoction containing Semen plantaginis, Philippine Violet Herb and Chinese lobelia for chronic pelvic inflammatory disease. The decoction comprises 4-7 wt% of Semen plantaginis, 10-13 wt% of Philippine Violet Herb, 4-7 wt% of Chinese lobelia, 6-8 wt% of Gorgon fruit, 3-5 wt% of Obscured homalomena rhizome, 2-4 wt% of Angelica pubescens, 0.5-2 wt% of Momordica cochinchinensis, 3-6 wt% of Sophora flavescens, 4-7 wt% of Portulacae Herba, 2-6 wt% of Cortex Phellodendri, 2-5 wt% of Fructus Cnidii, 9-12 wt% of Smilax glabra, 4-7 wt% of dandelion, 4-7 wt% of honeysuckle, 2-5 wt% of Radix Paeoniae Rubra, 2-4 wt% of Chinese prickly ash, 2-4 wt% of licorice, 2-4 wt% of Herba Andrographitis, and 3-5 wt% of Rhizoma Cibotii as raw materials. The decoction is prepared by immersing the raw materials in water, decocting, then filtering to obtain a filtrate. The decoction has the advantages of low cost, high curative effect for treating chronic pelvic inflammatory disease, and no toxic and side effects.

Description

Former purple lotus decoction for chronic pelvic inflammatory disease

technical field

The invention relates to a Chinese patent medicine preparation, in particular to a former purple lotus decoction for chronic pelvic inflammatory disease.

Background technique

As we all know, chronic pelvic inflammatory disease is caused by the incomplete treatment of acute pelvic inflammatory disease, or the protracted course of the disease in patients with poor physical fitness, but there may be no history of acute pelvic inflammatory disease, such as salpingitis caused by Chlamydia trachomatis infection. Chronic pelvic inflammatory disease is more stubborn, and when the body's resistance is weak, there may be acute attacks. Part of chronic pelvic inflammatory disease is the pathological change left over from acute pelvic inflammatory disease, and there is no pathogen. Its clinical manifestations: chronic pelvic pain, cicatricial adhesions formed by chronic inflammation, and pelvic congestion often cause lower abdominal swelling, pain, and lumbosacral pain, which often aggravate after fatigue, sexual intercourse, and before and after menstruation; tubal adhesions can cause infertility Or ectopic pregnancy; sometimes only low-grade fever, easy to fatigue, because of a long course of disease, some patients may have symptoms of neurasthenia; if it is endometritis, the uterus is enlarged and tender; if it is salpingitis, it is on the side of the uterus Or both sides of the palpable cord-like thickened fallopian tubes with mild tenderness; if it is hydrosalpinx or salpingo-ovarian cyst, cystic masses are touched on one or both sides of the pelvic cavity, and the activities are often limited; In pelvic connective tissue inflammation, the uterus is often retroflexed, limited in mobility or fixed by adhesions, flaky thickening and tenderness on one or both sides of the uterus, and uterosacral ligaments are often thickened, hardened, and tender. It belongs to the category of "leakage disease" in traditional Chinese medicine. Clinically, due to the wide application of antibiotics, bacteria develop drug resistance, repeated inflammation leads to fibrosis and thickening of genital organs and connective tissue in the pelvic cavity, and drugs are not easy to penetrate, causing great pain and economic burden to patients.

Contents of the invention

The purpose of the present invention is to overcome the above-mentioned existing technical deficiencies, to provide a low-cost, high curative effect for the treatment of chronic pelvic inflammatory disease, no toxic side effects, and has the effects of clearing away heat and detoxifying dampness, promoting blood circulation, removing blood stasis and regulating qi, soothing the liver, dissipating stagnation and reducing swelling. , for chronic pelvic inflammatory disease.

The technical scheme adopted by the present invention to solve the above-mentioned technical problems is: a kind of former purple lotus soup for chronic pelvic inflammatory disease, its technical feature is, adopt plantain seed, viola chinensis, lobelia, Gorgon fruit, Qiannianjian, Duhuo, wood Turtle seed, sophora flavescens, purslane, cortex, cnidium, smilax, dandelion, honeysuckle, red peony, pepper, licorice, andrographis paniculata, dog ridge as raw materials, soaked in water, decocted and then removed residue to obtain filtrate, composition of raw materials Calculated by weight percentage, psyllium 4-7%, Viola 10-13%, Lobelia 4-7%, Gorgon 6-8%, Millennium 3-5%, Duhuo 2-4%, Wood turtle 0.5～2% of flavescens, 3～6% of Sophora flavescens, 4～7% of purslane, 2～6% of Cortex Phellodendri, 2～5% of Fructus Cnidii, 9～12% of Smilax, 4～7% of Dandelion, 4～ 7%, Radix Paeoniae Rubra 2-5%, Zanthoxylum bungeanum 2-4%, Licorice 2-4%, Andrographis 2-4%, Dog Ridge 3-5%.

The invention has the beneficial effects of low cost, high curative effect for treating chronic pelvic inflammatory disease, no toxic and side effects, clearing heat, detoxifying and promoting dampness, promoting blood circulation, removing blood stasis and regulating qi, soothing liver, resolving stagnation and reducing swelling, and is suitable for chronic pelvic inflammatory disease.

Detailed ways

Below in conjunction with embodiment the present invention will be further described:

Example 1:

Plantago seed, Viola chinensis, Lobelia, Gorgon seed, Millennium Jian, Duhuo, Squid, Sophora flavescens, Purslane, Phellodendron, Cnidium, Smilax cocos, Dandelion, Honeysuckle, Red peony root, Zanthoxylum bungeanum, Licorice, Andrographis paniculata and dog ji are prepared from raw materials. Its components (% by weight) per pair are Plantago 6.2, Viola 12.1, Lobelia 6.1, Gorgon 7.1, Millennium 4.3, Duhuo 3.5, Gacia 1.2, Sophora 5.2, Purslane 5.6, Phellodendron 4.2 , Cnidium 3.1, Smilax 11.2, Dandelion 6.3, Honeysuckle 5.9, Radix Paeoniae Rubra 3.9, Zanthoxylum bungeanum 3.3, Licorice 3.2, Andrographis 3.4, Dog Ridge 4.2. The total weight of the above 19 flavors of raw materials is 254 grams. First, wrap the plantain seed with gauze, add 2000ml of water to the remaining 18 flavors of Chinese herbal medicine, soak at room temperature for about 4 hours, then boil with strong fire and simmer for 60-80 minutes. About 300ml of filtrate was obtained from the dregs, and 300ml of water was added to the dregs of the medicine, and it was boiled for about 30 minutes. After removing the dregs, about 100ml of filtrate was obtained, and a total of about 400ml of medicinal juice was obtained. Take 1 dose per day, 2 times in the morning and 2 times in the evening, take 100ml each time on an empty stomach, and keep the remaining 200ml of medicine juice for enema once a night. Instruct the patient to rest for half an hour after defecation before doing the retention enema. Raise the buttocks by 10cm, the liquid temperature is 39-41°C, take the right side lying position, gently insert the anal canal about 15cm, inject the liquid medicine slowly, raise the anal canal so that the liquid medicine is fully injected, pinch the anal canal tightly and pull out . One month is a course of treatment, rest for 3 days, and then proceed to the next course of treatment, usually three courses of treatment.

The main drug of the present invention, plantago seed, has diuretic effect, can increase excretion of urea, sodium chloride and uric acid, can increase tracheal and bronchial secretions, deepen and slow breathing movement, and has the effect of eliminating phlegm and relieving cough. Sweet in nature and slightly cold in flavor, returns to the Liver, Kidney, Lung and Small Intestine Meridians. It has the effects of clearing away heat and diuresis, expelling dampness and treating stranguria, improving eyesight, and eliminating phlegm. It is used for edema, fullness, astringent pain due to hot stranguria, diarrhea due to summer heat, red eyes and swelling pain, phlegm heat, and cough. Violadin has a strong inhibitory effect on Staphylococcus aureus and catarrhal coccus, and also has inhibitory effects on group A streptococcus and pneumococcus. Bitter in nature and flavor, pungent, cold, GUIXIN, Liver Channel. It has the effects of clearing away heat and detoxification, cooling blood and reducing swelling, and is used for furuncle swelling, carbuncle and gangrene on the back, erysipelas, snake bites, etc. Lobelia animal experiments have proved that this product has a diuretic effect and has a protective effect on dogs bitten by poisonous snakes. It can excite breathing, has hemostatic effect, antibacterial test: it has inhibitory effect on Staphylococcus aureus, typhoid fever, paratyphoid bacillus, Escherichia coli, Pseudomonas aeruginosa, etc. Pungent in nature and flavor, flat, Guixin, small intestine, lung meridian. It has the effects of diuresis, detumescence, heat-clearing and detoxification, and is used for abdominal edema, facial and foot edema, carbuncle and furuncle, snake and insect bites, etc. Gorgon fruit is sweet, astringent, flat in nature and taste, and belongs to the spleen and kidney meridian. It has the effects of nourishing the kidney and strengthening essence, nourishing the spleen and stopping diarrhea, dispelling dampness and stopping leukorrhea. Millennium health properties are bitter, pungent, and warm, and return to the liver and kidney meridians. It has the effects of dispelling rheumatism and strengthening muscles and bones. The independent active flavor is pungent, bitter, tepor, returns kidney, urinary bladder meridian, has expelling wind and dampness, unblocking numbness and relieving pain effect, is used for anemofrigid-damp arthralgia, waist and knee pain, Shaoyin volt wind headache. The fruit of the wood turtle is bitter in nature and flavor, slightly sweet, cool, poisonous, and returns to the liver, spleen, and stomach meridian. Psoriasis, bald sores. Sophora flavescens is bitter and cold in nature and taste, and it has the effects of clearing away heat and dampness, killing insects and diuresis, and is used for dysentery, blood in the stool, jaundice, urinary retention, red and white vaginal discharge, vaginal swelling and itching, Eczema, eczema, skin itching, mange and leprosy, external treatment of trichomonal vaginitis. Purslane is sour and cold in nature, returns to the liver and large intestine meridian, has the effects of clearing heat and detoxifying, cooling blood and stopping bleeding, and is used for toxic heat and bloody dysentery, carbuncle furuncle, eczema, erysipelas, snake bites, blood in the stool, hemorrhoids, Metrorrhagia and bleeding. Phellodendron Phellodendri is bitter and cold in nature, returns to the kidney and bladder meridians, has the effects of clearing heat and dampness, purging fire and removing steam, detoxifying and treating sores, and is used for damp-heat diarrhea, jaundice, leukorrhea, heat dysentery, beriberi, etc. Fructus Cnidii nature and flavor are pungent, bitter, warm, have little poison, return kidney meridian, have warming kidney and strengthening yang, drying damp, expelling wind, desinsection effect, are used for impotence, uterine cold, cold-damp leukorrhagia, damp arthralgia lumbago; Control vulva eczema, vulva pruritus, trichomonas vaginitis. Smilax tuckahoe is sweet, light and flat in nature and flavor, returns to the liver and stomach meridians, has the effects of dehumidification, detoxification, and tonic joints. Limb spasms, muscle and bone pain. Dandelion is bitter, sweet, and cold in nature and taste, and returns to the liver and stomach meridian. It has the effects of clearing away heat and detoxifying, reducing swelling and dispelling stagnation, diuresis and treating stranguria. It is used for boils and swelling, mastitis, scrofula, red eyes and sore throat, lung abscess, intestinal abscess, damp-heat jaundice, hot dripping pain. Honeysuckle nature and flavor are sweet, cold, return lung, heart, stomach meridian, have heat-clearing and toxic substances removing, cooling wind-heat effect, are used for carbuncle furuncle, sore throat, erysipelas, heat-toxin bloody dysentery, wind-heat cold, febrile disease fever. Radix Paeoniae Rubra is bitter in nature, slightly cold, and returns to the Liver Meridian. It has the effects of clearing away heat and cooling blood, dissipating blood stasis, and relieving pain. Zanthoxylum bungeanum is pungent and warm in nature and taste, and returns to the spleen, stomach and kidney meridians. It has the effects of warming the middle and relieving pain, killing insects and relieving itching. Glycyrrhiza licorice is sweet and flat in nature and flavor, and returns to the heart, lung, spleen, and stomach meridian. It has the effects of nourishing the spleen and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and carbuncle, and reconciling various medicines. It is used for weakness of the spleen and stomach, fatigue, palpitations, shortness of breath, and cough Excessive phlegm, epigastric pain, acute pain in the limbs, carbuncle and sore, relieve drug toxicity and potency. Andrographis paniculata nature and flavor are bitter, cold, return to the heart, lung, large intestine, bladder meridian, have heat-clearing and toxic substances removing, cooling blood, detumescence effect, are used for cold and fever, sore throat, aphtha of the mouth and tongue, sudden cough and overworked cough, diarrhea dysentery, febrile Drenching astringent pain, carbuncle sores, poisonous snake bites. Dog's spine is bitter, sweet and warm in nature and taste, returns to the liver and kidney channels, has the effects of nourishing the liver and kidney, strengthening the waist and knees, and dispelling rheumatism.

The 19 Chinese herbal medicines are ingeniously formulated and scientifically compatible. The auxiliary medicine can improve the efficacy of the main medicine, and the medicine with the same or similar performance and efficacy can enhance the curative effect and reduce or eliminate the side effects. It has the characteristics of definite curative effect, no drug resistance, and low possibility of recurrence. The medicines coordinate with each other, and it plays the special effect of chronic pelvic inflammatory disease.

The various raw materials of the present invention can also be realized by mixing the ratios (percentage by weight) listed in the table below. Its processing technology is identical with embodiment 1.

Below in conjunction with our hospital, the clinical trial that Wendeng Central Hospital, Weihai City, Shandong Province carries out further, describes the present invention in detail:

Case selection: The selected cases came to our hospital for diagnosis and treatment. According to the characteristics of clinical symptoms, combined with gynecological examination, vaginal secretion detection, B-ultrasound and other auxiliary examinations, 69 female patients with chronic pelvic inflammatory disease were diagnosed, aged 22 to 50 years, and pregnancy was excluded. , breastfeeding women and patients with serious diseases such as heart, liver, kidney and spirit.

Diagnostic criteria: TCM diagnostic criteria refer to the "Diagnosis and Curative Effect Criteria of TCM Diseases" issued by the State Administration of Traditional Chinese Medicine.

2. Treatment method: 1 dose per day, 2 times in the morning and 2 times in the evening, take 100ml on an empty stomach each time, and keep the remaining 200ml of medicine juice as an enema once every night before going to bed. First, ask the patient to rest for half an hour after defecation before doing the retention enema, lift the buttocks The height is 10cm, the liquid temperature is 39-41°C, take the right side lying position, gently insert the anal canal about 15cm, inject the liquid medicine slowly, raise the anal canal to make the liquid medicine fully injected, pinch the anal canal tightly and pull out. One month is a course of treatment, rest for 3 days, and then proceed to the next course of treatment, three courses of treatment.

3. Efficacy judgment:

Cure: After 3 courses of treatment, clinical symptoms and signs such as lumbosacral pain disappeared completely, gynecological examination, vaginal secretion test, and B-ultrasound examination were all normal, and there was no recurrence after half a year of drug withdrawal.

Significant effect: After 3 courses of treatment, clinical symptoms and signs such as lumbosacral pain were significantly relieved, a small amount of inflammation in vaginal secretions, and B-ultrasound examination were significantly improved, and mild subjective symptoms appeared after half a year of drug withdrawal.

Effective: After 3 courses of treatment, the clinical symptoms and signs such as lumbosacral pain were alleviated, the inflammation of vaginal secretions was alleviated, the B-ultrasound examination was improved, and there was recurrence after stopping the drug.

Ineffective: There is no improvement in clinical symptoms and signs and auxiliary examinations before and after treatment.

Therapeutic effect: use 69 routine female patients of the present invention, treat three courses of treatment, and observe half a year, apply curative effect evaluation standard to carry out therapeutic effect evaluation: 43 cases are cured, 16 cases are markedly effective, 6 cases are effective, and 4 cases are invalid. The total effective rate is 94%.

Claims (1)

1. a kind of former purple lotus decoction for chronic pelvic inflammatory disease, its technical feature is: adopt Semen Plantaginis, Zihua Diding, Lobelia, Euryale Gorgon, Millennium Health, Duhuo, Squid, Sophorae Sophorae, Purslane, Cortex Phellodendri, Fructus Cnidii, Smilax Poria, Dandelion, Honeysuckle, Radix Paeoniae Rubra, Zanthoxylum bungeanum, Licorice, Andrographis paniculata, and Dogji are raw materials, soaked in water, decocted, and then slag-removed to obtain a filtrate. The composition of the raw materials is calculated by weight percentage. ～7%, Viola 10～13%, Lobelia 4～7%, Gorgon 6～8%, Qiannianjian 3～5%, Duhuo 2～4%, Gacia 0.5～2%, Sophora 3～ 6%, Purslane 4-7%, Phellodendron 2-6%, Cnidium 2-5%, Smilax 9-12%, Dandelion 4-7%, Honeysuckle 4-7%, Radix Paeoniae Rubra 2-5%, Zanthoxylum bungeanum 2-4%, licorice 2-4%, andrographis 2-4%, dog ridge 3-5%.